Define benzofuran. benzofuran synonyms, benzofuran pronunciation, benzofuran translation, English dictionary definition of benzofuran. n. A colorless liquid, C8H6O, found in coal tar and used to make thermoplastic resins for paints and varnishes. Also called coumarone . n a colourless...

TY - JOUR. T1 - Structure-dependent reduction in DNA I-compound adducts by polychlorinated dibenzofurans in female Sprague-Dawley rat liver. AU - Randerath, K.. AU - Randerath, E.. AU - Reddy, R.. AU - Narasimhan, T. R.. AU - Wang, X.. AU - Safe, S.. PY - 1992. Y1 - 1992. N2 - The effects of polychlorinated dibenzofurans (PCDFs) on hepatic I-compound DNA adducts in female Sprague-Dawley rats were determined at 2 dose levels. In the first experiments, rats (4 per group) were treated with each of 3 polychlorinated dibenzofuran (PCDF) congeners at 20 μg/kg/week or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 10 μg/kg/week for 4 weeks. Effects on total I-compound levels when compared with age-matched control animals (corn oil) were as follows: control (116) , 1,2,4,7,8-pentachlorodibenzofuran (PeCDF) (112) , 1,2,3,7,8-PeCDF (93) , 2,3,4,7,8-PeCDF (91) , TCDD (72) where the numbers in parentheses were the number of I-compounds in 109 DNA nucleotides. In the second experiment, rats (5 per group) ...

Polychlorinated dibenzofurans (PCDFs) are a family of organic compounds with one or several of the hydrogens in the dibenzofuran structure replaced by chlorines. For example, 2,3,7,8-tetrachlorodibenzofuran (TCDF) has chlorine atoms substituted for each of the hydrogens on the number 2, 3, 7, and 8 carbons (see structure in the upper left corner of the second image). Polychlorinated dibenzofurans are much more toxic than the parent compounds, with properties and chemical structures similar to polychlorinated dibenzodioxins. These groups together are often inaccurately called dioxins. They are known teratogens, mutagens, and suspected human carcinogens. PCDFs tend to co-occur with polychlorinated dibenzodioxins (PCDDs). PCDFs can be formed by pyrolysis or incineration at temperatures below 1200 °C of chlorine containing products, such as PVC, PCBs, and other organochlorides, or of non-chlorine containing products in the presence of chlorine donors. Dibenzofurans are known persistent organic ...

The domino three-component coupling reaction of arynes with DMF and active methylenes or methines was studied as a highly efficient method for preparing heterocycles. Coumarin derivative 5 was formed when diethyl malonate (2) or α-bromomalonate (3) were used as a C2-unit. In contrast, dihydrobenzofurans 7a and 7b were obtained by using α-chloroenolates generated from α-chloromalonates 4a and 4b and Et2Zn. The benzofuran 15a could be obtained by using ethyl iodoacetate (14) as a C1-unit. The one-pot conversion of dihydrobenzofurans 7a, 7b and 8a into benzofurans 15a and 15b was also studied. The direct synthesis of benzofuran 15b was achieved by using the active methine 18 having ketone and ester groups.

Allsop, David and Gibson, Gillian and Martin, Ian K. and Moore, Susan and Turnbull, Stuart and Twyman, Lance J. (2001) 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide. Bioorganic and Medicinal Chemistry Letters, 11 (2). pp. 255-257. ISSN 0960-894X Full text not available from this repository ...

This report provides a national inventory of olychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran emissions to air, land and water from known sources for 2012, together with estimates of the amount of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran present within reservoir sources. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran Read more ...

This report provides a national inventory of olychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran emissions to air, land and water from known sources for 2012, together with estimates of the amount of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran present within reservoir sources. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran Read more ...

A gas chromatography coupled to triple-quadrupole mass spectrometry (GC-(QqQ)MS/MS) including a soft-ionization through an atmospheric pressure chemical ionization (APCI) source based method was compared with the high resolution mass spectrometry (HRMS) standard reference method EN1948, for the analysis of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) in stack gas emissions. The stack emission samples were collected, both, by manual method sampling (from 6 to 8h) and by long-term sampli

Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. - Xingxing Diao, Pan Deng, Cen Xie, Xiuli Li, Dafang Zhong, Yifan Zhang, Xiaoyan Chen

Article Multiple lines of evidence risk assessment of American robins exposed to polychlorinated dibenzofurans (PCDFS) and polychlorinated dibenzo‐P‐dioxins (PCDDS) in the Tittabawassee River floodplain, Midland, Michigan, USA. Concentrations of poly...

Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1. - Xingxing Diao, Xiaoyan Pang, Cen Xie, Zitao Guo, Dafang Zhong, Xiaoyan Chen

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were synthesised and their affinities determined for adenosine A1 and A2A receptors via radioligand binding assays to establish the structure ...

Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al. J. Med. Chem.201154 5522-5531). To identify the site of binding of SBDs, we studied thrombin inhibition in the presence of exosite 1 and 2 ligands. Whereas hirudin peptide and heparin octasaccharide did not affect the IC(50) of thrombin inhibition by a high affinity SBD, the presence of full-length heparin reduced inhibition potency by 4-fold. The presence of γ fibrinogen peptide, which recognizes Arg93, Arg97, Arg173, Arg175, and other residues, resulted in a loss of affinity that correlated with the ideal Dixon-Webb competitive profile. Replacement of several arginines and lysines of exosite 2 with alanine did not affect thrombin inhibition potency, except for Arg173, which displayed a 22-fold reduction in IC(50). Docking studies suggested a hydrophobic patch around Arg173 as a plausible site of SBD binding to thrombin. The absence of the Arg173-like residue in factor Xa ...

The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T and Treprese

80592-86-5 - ZLZINPAIXXXARB-UHFFFAOYSA-N - Benzofuran, 5-bromo-2-(diethylaminomethyl)-3-phenyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.

BUY 6-APB ONLINE, 6-(2-aminopropyl)benzofuran (also known as 6-APB or by the brand-name Benzofury) is a popular synthetic entactogen of the phenethylamine

Experimental studies have shown that dioxin-like chemicals may interfere with aspects of the endocrine system including growth. However, human background population studies are, however, scarce. We aimed to investigate whether early exposure of healthy infants to dioxin-like chemicals was associated …

Find out more about Lancaster Universitys research activities, view details of publications, outputs and awards and make contact with our researchers.

A total number of 120 healthy subjects (with an approximate 1:1 female:male ratio) are planned to be randomised.. Day 1: a baseline ECG profile. Day 1: Group 1 will receive prucalopride, Group 2a will receive moxifloxacin, and Group 2b will receive placebo.. On Day 5 (steady-state level is reached), a full ECG assessment day will be performed, enabling the comparison of prucalopride 2 mg with placebo.. Subsequently, the number of tablets will be escalated in all groups (blinded) with 1 tablet a day up to 5 tablets.. On Day 13 (steady state for the supratherapeutic dose level of 10 mg of prucalopride) another ECG assessment day will be performed, enabling a comparison of prucalopride 10 mg with placebo.. Group 2b will receive a single dose of moxifloxacin on Day 15. All subjects will be discharged on Day 16. Subjects will remain in the CRU throughout the treatment period.. All subjects will return for a follow-up visit on Day 30 (± 1 week) (approximately 14 days after the last dose). ...

Pharmacyclics, Inc. (Nasdaq: PCYC) today announced interim data from a Phase I study of their novel orally administered Brutons tyrosine kinase (Btk) inhibitor PCI-32765 in patients

Mycoremediation, or fungus-based remediation, is an ex situ form of bioaugmentation, in which hazardous organics are degraded or detoxified by fungi that are introduced into the contaminated soil via a fungal inoculum. Due to the ability of white-rot fungi (WRF) to degrade extremely recalcitrant contaminants (e.g., high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), work on fungus-based remediation has focused on the treatment of soils contaminated with these types of chemicals. In addition, work has progressed on the soil microbiology of mycoremediation and on the development of techniques to monitor the fate of fungi inoculated into soils. Fallout of PCDDs and PCDFs from combustion at incineration facilities has resulted in serious pollution of the surrounding soil environment because of their extremely high persistence and toxicity. Importantly, the extent of the enhancement varied with soil and

Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide 433252-24-5 MSDS report, Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide MSDS safety technical specifications search, Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide safety information specifications ect.

Benzofuran-3(2H)-one 7169-34-8 MSDS report, Benzofuran-3(2H)-one MSDS safety technical specifications search, Benzofuran-3(2H)-one safety information specifications ect.

The biphenyl molecule is made up of two connected rings of six carbon atoms each, and a PCB is any molecule having multiple chlorines attached to the biphenyl nucleus. Two distinct classes of bacteria have now been identified that biodegrade PCBs by different mechanisms, including aerobic bacteria which live in oxygenated environments and anaerobic bacteria which live in oxygen free environments such as aquatic sediments. The aerobes attack PCBs oxidatively , breaking open the carbon ring and destroying the compounds. Anaerobes, on the other hand, leave the biphenyl rings intact while removing the chlorines. Polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) were introduced into the biosphere on a large scale as by-products from the manufacture of chlorinated phenols and the incineration of wastes. Due to their high toxicity they have been the subject of great public and scientific scrutiny. The evidence in the literature suggests that PCDD/F compounds are subject ...

This is a Phase 2 multicenter, randomized, double-blind, placebo-controlled, add-on study of NBP softgel capsules for the treatment of mild to moderate cortical

Svante Arrhenius väg 8, Stockholm. Arrheniuslaboratoriet, Svante Arrhenius väg 16, Stockholm (Unit for Analytical and Toxicological Chemistry). Mailing address: ...

Vizard, C. G., Rimmer, D. L., Pless-Mulloli, T., Singleton, I., & Air, V. S. (2006). Identifying contemporary and historic sources of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in an industrial urban setting. Science of the Total Environment, 370(1), 61 - 69. https://doi.org/10.1016/j.scitotenv.2006.06.006. ...

1-benzofuran-2-yl{methyl[(3-pyridin-4-ylisoxazol-5-yl)methyl]amino}acetic acid|ChemBridge Corporation|1-benzofuran-2-yl[methyl...

We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. This recyclable catalyst could be reused more than 5 times in the same heteroannulation reaction. The results have demonstrated that diverse 2-substituted benzofurans with tolerant functional groups can be prepared simply and conveniently under these conditions ...

Exposure to chlorinated dibenzo-p-dioxins (CDDs) (75 chemicals) occurs mainly from eating food that contains the chemicals. One chemical in this group, 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,3,7,8-TCDD, has been shown to be very toxic in animal studies. It causes effects on the skin and may cause cancer in people. This chemical has been found in at least 91 of 1,467 National Priorities List sites identified by the Environmental Protection Agency (EPA).

You are viewing an interactive 3D depiction of the molecule 6-methoxy-3-methyl-n-phenyl-n-[3-(1-piperidinyl)propyl]-1-benzofuran-2-carboxamide (C25H30N2O3) from the PQR.

N-(2-Fluorophenyl)-4-[5-[(3-methyl-1-benzofuran-2-carbonyl)amino]pyridin-2-yl]piperazine-1-carboxamide | C26H24FN5O3 | CID 52917631 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Structure, properties, spectra, suppliers and links for: Ethyl {[(2Z)-2-(2-furylmethylene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl]oxy}acetate.

Structure, properties, spectra, suppliers and links for: Methyl {[(2Z)-3-oxo-2-(2,3,4-trimethoxybenzylidene)-2,3-dihydro-1-benzofuran-6-yl]oxy}acetate.

1-[(5-Nitro-2-phenyl-1-benzofuran-3-yl)methyl]piperidine | C20H20N2O3 | CID 558839 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Madonna (True Blue) is a Screen Print by contemporary artist Agent X. From a limited edition of 40, the print is signed and numbered by the artist.

A Quinolino novel series[3,2-f] [1,2,4] The [3,4-b] Triazolo [1,3,4] The Thiadiazepine (7a-i) derivatives incorporated with 3-(5-i) (benzofuran-2-yl) -1-phenyl-1H-3-yl pyrazol) Moiety was synthesised by a 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)) one-point cyclo-condensation reaction. -4-amino-4H-1,2,4-triazole-3-thiol (4) in the presence of K2CO3 in DMF with 2-chloro-quinoline-3-carbaldehyde derivatives (6a-i). Characterization of 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-substituted quinolino [3,2-f] newly synthesised compounds [1,2,4] triazolo[3,4-b] triazolo Elemental analysis and spectral studies such as FT-IR, 1H NMR and 13C NMR, further assisted by Mass Spectra, have been performed with[1,3,4]thiadiazepines. Both synthesised compounds were tested in vitro against the pathogenic microorganism bacterial strains, S. aureus E.coli, P.vulgaris, S.typhi at different concentrations for their antimicrobial activities. In comparison with Chloramphenicol, the bioassay outcome ...

8-[5-(diethylamino)pentylamino]quinolin-6-ol,8-[5-(propan-2-ylamino)pentan-2-ylamino]quinolin-6-ol,8-(5-azanylpentylamino)quinolin-6-ol,8-acetamidooctadecanoic acid,8-heptylselanyloctanoic acid,8-methyl-3-phenyl-1,4-dioxaspiro[4.5]decane,8-methyl-5-nitro-quinoline,8-[bis(2-hydroxyethyl)amino]-1,3-dimethyl-7H-purine-2,6-dione,8,10-bis(oxidanylidene)-9-azaspiro[5.5]undecane-11-carbonitrile,8-fluoranylbenzo[e][2]benzofuran-1,3-dione,8-fluoranyl-4,5-dihydrobenzo[e][2]benzofuran-1,3-dione,8-fluoranyl-3,3-diphenyl-benzo[g][2]benzofuran-1-one,8-[[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]methoxymethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-chloranyl-7-(chloromethyl)-1,3-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)aminomethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[bis(2-chloroethyl)aminomethyl]-3,7-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)amino]-3,7-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)amino]-1,3-dimethyl-7H-purine-2,6-dione,8-(diethylaminomethyl)-1,3,7-trimethyl-purine-2,6-dione,8

Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from your marine sp. indicated a 1,2,3-trisubstituted benzene ring by signals of in Hz) = 1.6 Hz), which requires a coplanar orientation of the connecting bonds. This is accomplished only if rings B and C will also be spp. [5,8,9,10,11,12]. None of them has an 11-oxabenzo[bc]aceanthrylene skeleton like 1. However, a similar benzofuran was created very easily as an intermediate in the synthesis of hatomarubigin [13]. 2.2. Biological Activity In the cytotoxicity checks, kiamycin (1) exhibited activity against human being cell lines, namely HL-60 (leukemia), lung adenocarcinoma cells A549, and the hepatoma cell series BEL-7402 with inhibition beliefs of 68.2%, 55.9%, and 31.7% at 100 M; adriamycin as positive control demonstrated inhibition prices of 70.0%, 79.3%, and 80.0%, respectively (Desk Trametinib 2). Both substances had been cytotoxicity against HL-60 equivalently, while 1 ...

Compositional information provided by the Sponsor indicated the presence of a number of isomers of the test item (2,6-dimethyl-3a-(propan-2-yl)octahydro-1-benzofuran), which in total represent the reported purity for this substance. Using this information, the calculation of the test item water solubility was calculated based on the total peak area of all peaks obtained on chromatographic analysis which were attributed to these isomers of the test item. On comparison of the relative peak/isomer responses for the test item standard and sample solutions, there was no evidence of significant selective solubility/extractivity, with all test item peaks/isomers being detected, at a similar ratio, on analysis of the water solubility sample solutions ...

4B11: Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.

H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H(3) receptors, with K(i) values of 0.1-5.8 nM. Analogues were discovered with potent (0.01-1 mg/kg) cognition and attention enhancing properties in animal models. On …

Sigma-Aldrich offers abstracts and full-text articles by [Yibin Xiang, Bradford Hirth, Gary Asmussen, Hans-Peter Biemann, Kimberly A Bishop, Andrew Good, Maria Fitzgerald, Tatiana Gladysheva, Annuradha Jain, Katherine Jancsics, Jinyu Liu, Markus Metz, Andrew Papoulis, Renato Skerlj, J David Stepp, Ronnie R Wei].

I knew an old boy who mounted a barrel behind the axle on his old Farmall so he could take his kid to the field with him and not worry about losing him to a tragic run-over accident. I bet he knew someone who lost a child that way. When riding the fender, axle, or a parents lap, a kid can fall forward and be run over by the rear wheel of a tractor. It does happen! Passengers should not be riding on tractors unless modifiations are added to make it safe. Families never really recover from tragedies that kill their kids, and the emergency personnel that have to clean up the aftermath carry those images in their heads, too. Kids are precious, and cant be replaced, so dont do what this guy is doing, and that goes for your riding lawnmower, too ...

The Dodgers will get Cody Bellinger and Zach McKinstry back on Saturday against the Giants, with Bellinger starting in center field in the final two games of the series. Plus rehab updates on AJ Pollock, Jimmy Nelson, and Brusdar Graterol.

May and friends are walking through the woods when they find a wounded Swablu. Swablu puts the kids to sleep with Sing, but Torchic wakes them up by pecking their noses.

The Dodgers have different managers and several different coaches at all six of their domestic minor league affiliates in 2016 compared to 2015.

Epidural fibrosis (EF) is a common complication after laminectomy. Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties. The object of this study was to investigate the effect of Sal B on the prevention of epidural fibrosis in laminectomy rats. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. The rats were randomly divided into 3 groups of 20: (1) Sal B treatment group; (2) Vehicle group; (3) Sham group (laminectomy without treatment). All rats were sacrificed 4 weeks post-operatively. The extent of epidural fibrosis, fibroblast proliferation and the expression of vascular endothelial growth factor (VEGF) and inflammatory factors were analyzed. The recovery of all rats was uneventful. In the laminectomy sites treated with Sal B, the dura mater showed no adhesion. Collagen

Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). In this study, we analyzed the effects of DSU, SAB and a S. miltiorrhiza extract (SME) on cell proliferation. Additionally, the effects of DSU and SAB on collagen synthesis in Detroit 551 human normal fibroblast cells and on melanin production in B16 melanoma cells were verified. The results demonstrated that SME can enhance the proliferation of Detroit 551 cells and that this boost may be caused by DSU and SAB. This research showed that SME, DSU and SAB all have the ability to increase the production of collagen in Detroit 551 cells. The results also confirmed that DSU and SAB can attenuate the α-MSH-stimulated melanin production of B16 cells by inhibiting tyrosinase activity. Therefore, SME, DSU and SAB each have the potential to be utilized as active ingredients in wound healing or cosmetic treatments. In the future, DSU and SAB could also be used as functional components

Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.

Usnic acid is a dibenzo-furandione which is uniquely found in lichen (Usnea) species, which are distributed worldwide. In vitro usnic acid has antibacterial, antifungal and antiviral activities, and lichen extracts containing usnic acid have been used in folk medicine externally for wound healing and athletes foot and internally for sore throat, toothache and fever. Usnic acid has also found several commercial uses, largely in perfumery and cosmetic products, but also in medicinal creams. However, usnic acid appears to be toxic when taken orally in high doses and, for instance, can cause ataxia and paralysis in animals grazing on lichen contaminated crops and grains. Usnic acid has been purified and extensively studied in vitro and has been shown to uncouple oxidative phosphorylation in isolated mitochondria, which may account for its broad antimicrobial activity. Uncoupling of oxidative phosphorylation by decreasing the efficacy of energy use and causing increased thermogenesis has been ...

Salvianolic Acid directory ☆ Salvianolic Acid manufacturers, suppliers ☆ Salvianolic Acid buyers, importers, wholesalers, distributors

ABSTRACTThe annual variations of wet deposition of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in atmosphere were measured at two sites (A and B) near two municipal solid waste incinerators (MSWIs) in southern Taiwan. Results showed that particle scavenging dominates in the wet deposition processes for the removal of PCDD/Fs from the atmosphere, the highest value was observed at the highest chlorinated congener. The ambient temperature and the amount of precipitation played an important role in the variation of PCDD/F deposition fluxes. It was found that temperature was inversely associated with the existence of particulate PCDD/Fs, indicating PCDD/Fs are scavenged most efficiently in cold weather. PCDD/F wet deposition fluxes in rainy seasons (from June to August) were significantly higher than those in dry seasons (from December to February), revealing a positive relationship between wet deposition flux and monthly rainfall. Additionally, the annual total (dry + wet) deposition

Results of recent studies showed that 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are equipotent in domestic chicken (Gallus gallus domesticus) while PeCDF is more potent than TCDD in ring-necked pheasant (Phasianus colchicus) and Japanese quail (Coturnix japonica). To elucidate the mechanism(s) underlying these differences in relative potency of PeCDF among avian species, we tested the hypothesis that this is due to species-specific differential binding affinity of PeCDF to the aryl hydrocarbon receptor 1 (AHR1). Here, we modified a cell-based binding assay that allowed us to measure the binding affinity of dioxin-like compounds (DLCs) to avian AHR1 expressed in COS-7 (fibroblast-like cells). The results of the binding assay show that PeCDF and TCDD bind with equal affinity to chicken AHR1, but PeCDF binds with greater affinity than TCDD to pheasant (3-fold) and Japanese quail (5-fold) AHR1. The current report introduces a COS-7 whole-cell binding ...

In vitro analysis of polychlorinated biphenyls (PCBs) and 2,3,4,7,8-pentachlorodibenzofuran (PCDF) cellular toxicity in PLC/PRF/5 cell proliferation--the effect of ursodeoxycholic acid, inchin-gorei-san and shou-saiko-to on cell toxicity.

Mass spectrometry/mass spectrometry (MS/MS) has been shown to be useful in the analysis of environmental samples for low (ppt) levels of compounds like polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in cases where interfering materials present in the samples made analysis by high resolution mass spectrometry (HRMS) difficult or impossible. While the technique shows promise because of its high selectivity, researchers have reported stability problems with mass spectrometry/mass spectrometry instruments and other questions regarding the reproducibility of analytical results exist. This study was undertaken to develop an MS/MS method for the analysis of PCDD/Fs, determine the stability of an MS/MS instrument over a period of months and to compare analytical results obtained by MS/MS with those obtained by HRMS. The results demonstrated that by following the protocol developed in the study, an MS/MS instrument can generate reproducible analytical results over a period of months and ...

Title: Dronedarone: A Safety Comparison to Amiodarone. VOLUME: 5 ISSUE: 3. Author(s):James R. Clem, Debra K. Farver, Janet R. Fischer and Thomas J. Johnson. Affiliation:South Dakota State University College of Pharmacy, 4801 North Career Avenue, Sioux Falls, SD 57107, USA.. Keywords:Dronedarone, SR 33589, amiodarone, atrial fibrillation, safety. Abstract: Dronedarone is an oral Class III antiarrhythmic agent which was recently approved by the US Food and Drug Administration for use in nonpermanent atrial fibrillation. Structurally similar to amiodarone, dronedarone is a benzofuran derivative but it lacks the iodine moiety attached to amiodarone. Based upon the investigational clinical trials to date, it appears that dronedarone has an established efficacy when compared to placebo along with exhibiting a minimal adverse effect profile. The efficacy of dronedarone will need to be further evaluated in comparison trials with established antiarrhythmics for atrial fibrillation. The adverse profile of ...

Dronedarone is a novel synthetic noniodinated benzofuran derivative that has been developed to eliminate the adverse effects of the most effective and commonly used antiarrhythmic drug, amiodarone. Dronedarones electrophysiological spectrum is largely similar to that of multichannel inhibitor//multitarget amiodarone. Some prospective, randomized, controlled clinical trials (DAFNE, EURIDIS/ADONIS, ERATO, ATHENA) have already suggested safety (low proarrhythmic potential, and lack of organ toxicity), sinus rhythm maintaining and/or ventricular rate controlling efficacy of dronedarone (800 mg/day). Opposing these, ANDROMEDA and PALLAS trials raised safety concerns for patients with systolic/congestive heart failure (CHF) and severe left ventricular dysfunction (LVEF ≤ 35%; NYHA III-IV) by doubling the cardiovascular mortality. Dronedarone could be useful second- or third-line agent for some of low-risk symptomatic intermittent (paroxysmal/persistent) AF patients who require rhythm control. ...

NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) DATE: 07/14/03 EXPERIMENT: 96007 TEST: 05 TIME: 14:21:29 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C96007F ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: BATTELLE COLUMBUS TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) DATE: 07/14/03 EXPERIMENT: 96007 TEST: 05 TIME: 14:35:48 SPECIES: RATS, SPRAGUE-DAWLEY TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 96007F CONT: NO1-ES-75411 CAS: 57117-31-4 MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) ...

Other data set: Additional PCB congeners are reported under data file name PCBPOL_F. Among these PCB congeners PCB 105, 114, 118, 156, 157, 167 and 189 has a toxic equivalence factor (TEF) and may be used with this data set for calculating a total TCDD equivalence.. Subsample Weights. PCDDs, PCDFs, and cPCBs were measured in a one-third subsample of participants 12 years and older. Special sample weights are required to analyze these data properly. Specific sample weights for this subsample are included in this data file and should be used when analyzing these data.. Samples were pooled in groups of 8 samples per pool within 40 demographic groups. The analysis of NHANES 2009-2010 pooled-sample data must be conducted with the basic demographic variables provided in this data file. This pooled-sample data file cannot be linked to other NHANES 2009-2010 data. Because each sample person does not have an equal probability of selection, sample weighting is needed to produce correct population ...

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The Minnesota Department of Health (MDH) has prepared this memo in response to your January 28, 2003, request for guidance on dioxin, as well as to identify a consistent approach for agencies and programs to assess the carcinogenic health risks from exposure to dioxin-like compounds. Guidance for assessing the noncancer health risks is still under development and will not be addressed in this memo. Because of the uncertainties associated with the toxicities of dioxin mixtures, MDH uses a conservative approach to evaluate potential risks. As more data become available, MDH re-evaluates and revises its risk assessment methods and procedures, as appropriate. Dioxin-like Compounds. The term dioxins is used to refer to a family of complex but related chlorinated compounds with similar chemical structures and biological activity. The polychlorinated dibenzo-p-dioxins (PCDDs) include 75 individual compounds, the polychlorinated dibenzofurans (PCDFs) include 135 individual compounds, and the ...

Provides information to potential participants on the following clinical trial: Phase I Dose-Escalation Study of Brutons Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Recurrent B Cell Lymphoma

Usnic acid, a lichen secondary metabolite inhibits Group A Streptococcus biofilms.: Group A Streptococci (GAS) are involved in a number of life threatening dise

Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The aim of this study was to determine the effect of usnic acid response-miR-185-5p on proliferation in the breast cancer cell and to determine its relationship with apoptosis pathway. The cell proliferation and cell apoptosis rate were significantly increased following the ectopic expression of miR-185-5p in BT-474 cells. Furthermore, the results of cell cycle assay performed by flow cytometry revealed that the transfection with miR-185-5p induced G1/S phase arrest. The apoptosis-related genes expression analysis was performed by qRT-PCR and the direct target of miR-185-5p in BT-474 cells was identified by western blot and luciferase reporter assay. Our data showed that miR-185-5p can cause significant changes in apoptosis-related genes expression levels, suggesting that cell proliferation was suppressed by miR-185-5p via

NTP Experiment-Test: 96007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03 Route: GAVAGE Time: 14:46:46 31 WEEK SSAC RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 57117-31-4 Lock Date: 07/25/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 11/03/99 - 11/04/99 Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03 Route: GAVAGE Time: 14:46:46 __________________________________________________________________________________________________________________________________ , 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, , , DAY ON TEST , 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, , , , 2, 1, 1, 1, 1, 1, 2, 2, 2, 2, 1, 1, 1, 1, 1, 2, , , ...

High levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in edible fish in the Baltic Sea have raised health concerns in the Baltic region and the rest of Europe. Thus, there are urgent needs to characterize sources in order to formulate effective mitigation strategies. The aim of this thesis is to contribute to a better understanding of past and present sources of PCDD/Fs in the Baltic Sea environment by exploring chemical fingerprints in sediments, air, and biota. The spatial and temporal patterns of PCDD/F distributions in the Baltic Sea during the 20th century were studied in Swedish coastal and offshore sediment cores. The results showed that PCDD/F levels peaked in 1975 (± 7 years) in coastal and 1991 (± 5 years) in offshore areas. The time trends of PCDD/Fs in the sediment cores also showed that environmental half-lives of these pollutants have been shorter in coastal than in offshore areas (15 ± 5 and 29 ± 14 years, respectively). Consequently, ...

Title:Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase. VOLUME: 19 ISSUE: 3. Author(s):Karolina Królewska-Golińska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrańska and Barbara Nawrot. Affiliation:Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, ...

Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways. International Journal of Cancer. Vol.124, No.9 (1 May 2009): 2200-2209. Yubin Hao, Tianpei Xie, Alexandru Korotcov, Yanfei Zhou, Xiaowu Pang, Liang Shan, Hongguang Ji, Rajagopalan Sridhar, Paul Wang, Joseph Califano, Xinbin Gu.. ...

Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways. International Journal of Cancer. Vol.124, No.9 (1 May 2009): 2200-2209. Yubin Hao, Tianpei Xie, Alexandru Korotcov, Yanfei Zhou, Xiaowu Pang, Liang Shan, Hongguang Ji, Rajagopalan Sridhar, Paul Wang, Joseph Califano, Xinbin Gu.. ...

The main air pollutants in the sintering process of iron ore are polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs) and harmful dust. Ore sintering on sinter strands is one of the first technology steps in the ironworks. It is a process in which iron ore is crushed, subjected to annealing and mixed with appropriate additives, and then sintered in order to produce sinter which is the main component of iron in the blast furnace process. PCDD/Fs emissions were measured and the addition of ammonium sulfate as an inhibitor of the synthesis of dioxins in the sintering process of iron ore was studied ...

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Yusho Disease is a condition caused by poisoning with polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). This primarily refers to a specific mass poisoning with PCBs and PCDFs in rice bran oil, which occurred in northern Kyushu, Japan, in 1968. About 14,000 people who had consumed the contaminated rice oil in Japan were affected. Common symptoms included some abnormalities on the skin and eye tissues, irregular menstrual cycles and a lowered immune system. Other symptoms included fatigue, headache, cough, and unusual skin sores. Additionally, in children, there were reports of poor cognitive development.. An almost identical case occurred in Taiwan a decade later in 1979, known as Yu-cheng disease.. ...

Prucalopride is an orally active enterokinetic compound that has been launched as a therapy for laxative-resistant chronic constipation. Prucalopride acts

Single-centre, double-blind, placebo-controlled, cross-over study in 33 healthy volunteers with 2 sessions. Each session consisted of a run-in day for baseline assessments, 8 treatment days and 5 additional days for followup assessments. Subjects were randomised to start with either the prucalopride or placebo session. The prucalopride dose was consecutively escalated in 2 mg steps per day, starting from 2 mg up to 10 mg once daily If a subject did not tolerate the 10- or 8-mg dose, 1 step back in the dosage scheme was allowed, from 10 to 8 mg on Day 6, or from 8 to 6 mg on Day 5. Subjects with intolerance for doses of less than 6 mg, were withdrawn from the study. Repeated dosing (6, 8 or 10 mg) was continued once daily until Day 8, to achieve steady-state. During placebo, the number of placebo tablets was consecutively escalated in an identical way as described for prucalopride. Between the 2 sessions, there was a washout period of 14 to 21 days, to avoid any carry-over effect ...

Kombucha contains multiple species of yeast and bacteria, along with the amino acids, enzymes, organic acids and polyphenols they produce.. It is also rich in B-complex vitamins and vitamin C (about 750mg per 500ml - the exact quantities vary between samples.). The chance of contamination by airborne moulds or bacterial spores is very low because of the mild alcoholic element (less than 0.5%) and its acidity; acetic acid, ethanol, gluconic acid, glucuronic acid, glycerol, lactic acid and usnic acid. Usnic acid possesses a wide range of intersecting biological properties.. It has been shown to have potent antibiotic effective against harmful bacteria, such as E. Coli, Staphylococcus, Streptococcus and Pneumococcus ...

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3H-Spiro[1-benzofuran-2,4-piperidine]/ACM71916739 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.

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Tickets are valid from opening day at Village Cinemas, Hoyts, EVENT Cinemas, Greater Union, Birch Carroll & Coyle, Reading Cinemas, Palace Cinemas, Wallis, Dendy, Grand Cinemas, AMC Cinemas and participating independent cinemas which are screening the film. Present this ticket at the box office and you will be entitled to one session only of RED DOG: True Blue (PG). Valid even with No Free Tickets restriction. Not valid all day Tuesday (or cinema discount days), Saturdays after 5.00pm or Public Holidays or in 3D, Gold Class and premium cinemas. The tickets must be used before the season ends at the cinemas ...

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Before hiring a company, ask them the process they use to clean carpets. You should hear that they begin with vacuuming before they start deep cleaning. The carpet is going to look much better when done, so if the cleaner refuses to vacuum, find another company.. While a carpet cleaner may not restore your carpet to its original glory, theres a good chance that it can come close. Keep these tips in mind when calling companies to help you determine the right carpet cleaner. Youll have great looking carpet again in no time by following the advice you learned in this article.. Carpet Cleaning. #carpetcleaningsydney #carpetcleaning #floodrestorationsydney. Contact Us:. True Blue Carpet ...

Previous investigations suggest that DL-3-n-butylphthalide (NBP) is a promising multifaceted drug for the treatment of stroke. It is not clear whether NBP can treat traumatic brain injury (TBI) and what could be the mechanisms of therapeutic benefits. To address these issues, TBI was induced by a controlled cortical impact in adult male mice. NBP (100 mg/kg) or saline was intraperitoneally administered within 5 min after TBI. One day after TBI, apoptotic events including caspase-3/9 activation, cytochrome c release from the mitochondria, and apoptosis-inducing factor (AIF) translocation into the nucleus in the pericontusion region were attenuated in NBP-treated mice compared to TBI-saline controls. In the assessment of the nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway, NBP ameliorated the p65 expression and the p-IκB-α/IκB-α ratio, indicating reduced NF-κB activation. Consistently, NBP reduced the upregulation of proinflammatory cytokines such as tumor ...

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Italy and #OperationGreenRights are still working on the data, about the chemical agents, contained in the dumps of Ilvas and Riva Groups database (www.ilvataranto.com & www.rivagroup.com). The chemical agents tables, sometimes, are not easy to read, sometimes is not possible to understand which is the real grade of production, of these materials, but is sure that some values are not crossable. Another certain is that these limits are applied by the law. The factories, which produce chemical agents over the limits set by the law, make this work dangerous for all the people who works in these places and for who lives in these cities. The limits are decided by the law, so are not changeable by the owners of these factories. One of the most dangerous chemical agent produced is furan (C4H4O). The furan is an organic persistent enviromental pollutant which naturally becames benzofuran polychlorinated, whom is associated to dioxins. Also normally, the furan is highly volatile close to room ...

You may also wish to search for items by Trinajstic. 11 matching references were found. Dewar, M.J.S.; Harget, A.J.; Trinajstic, N.; Worley, S.D., Ground states of conjugated molecules-XXI.Benzofurans and benzopyrroles, Tetrahedron, 1970, 26, 4505. [all data] Klasinc, L.; Trinajstic, N.; Knop, J.V., Application of photoelectron spectroscopy to biologically active molecules and their constituent parts. VIII. Thalidomide, Int. J. Quantum Chem., 1980, 7, 403. [all data] Galasso, V.; Klasinc, L.; Sabluic, A.; Trinajstic, N.; Pappalardo, G.C.; Steglich, W., Conformation and photoelectron spectra of 2-(2-Furyl)pyrrole and 2-(2-tThienyl)pyrrole, J. Chem. Soc. Perkin Trans. 2, 1981, 127. [all data] Lucic, B.; Nikolic, S.; Trinajstic, N.; Juric, A.; Mihalic, Z., A structure-property study of the solubility of aliphatic alcohols in water, Croat. Chem. Acta, 1995, 68, 417-34. [all data] Randic, M.; Plavsic, D.; Trinajstic, N., Aromaticity in polycyclic conjugated hydrocarbon dianions, THEOCHEM, 1989, 54, ...