Define benzofuran. benzofuran synonyms, benzofuran pronunciation, benzofuran translation, English dictionary definition of benzofuran. n. A colorless liquid, C8H6O, found in coal tar and used to make thermoplastic resins for paints and varnishes. Also called coumarone . n a colourless...
Polychlorinated dibenzofurans (PCDFs) are a family of organic compounds with one or several of the hydrogens in the dibenzofuran structure replaced by chlorines. For example, 2,3,7,8-tetrachlorodibenzofuran (TCDF) has chlorine atoms substituted for each of the hydrogens on the number 2, 3, 7, and 8 carbons (see structure in the upper left corner of the second image). Polychlorinated dibenzofurans are much more toxic than the parent compounds, with properties and chemical structures similar to polychlorinated dibenzodioxins. These groups together are often inaccurately called dioxins. They are known teratogens, mutagens, and suspected human carcinogens. PCDFs tend to co-occur with polychlorinated dibenzodioxins (PCDDs). PCDFs can be formed by pyrolysis or incineration at temperatures below 1200 °C of chlorine containing products, such as PVC, PCBs, and other organochlorides, or of non-chlorine containing products in the presence of chlorine donors. Dibenzofurans are known persistent organic ...
The domino three-component coupling reaction of arynes with DMF and active methylenes or methines was studied as a highly efficient method for preparing heterocycles. Coumarin derivative 5 was formed when diethyl malonate (2) or α-bromomalonate (3) were used as a C2-unit. In contrast, dihydrobenzofurans 7a and 7b were obtained by using α-chloroenolates generated from α-chloromalonates 4a and 4b and Et2Zn. The benzofuran 15a could be obtained by using ethyl iodoacetate (14) as a C1-unit. The one-pot conversion of dihydrobenzofurans 7a, 7b and 8a into benzofurans 15a and 15b was also studied. The direct synthesis of benzofuran 15b was achieved by using the active methine 18 having ketone and ester groups.
Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. - Xingxing Diao, Pan Deng, Cen Xie, Xiuli Li, Dafang Zhong, Yifan Zhang, Xiaoyan Chen
Article Multiple lines of evidence risk assessment of American robins exposed to polychlorinated dibenzofurans (PCDFS) and polychlorinated dibenzo‐P‐dioxins (PCDDS) in the Tittabawassee River floodplain, Midland, Michigan, USA. Concentrations of poly...
Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1. - Xingxing Diao, Xiaoyan Pang, Cen Xie, Zitao Guo, Dafang Zhong, Xiaoyan Chen
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A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were synthesised and their affinities determined for adenosine A1 and A2A receptors via radioligand binding assays to establish the structure ...
Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al. J. Med. Chem.201154 5522-5531). To identify the site of binding of SBDs, we studied thrombin inhibition in the presence of exosite 1 and 2 ligands. Whereas hirudin peptide and heparin octasaccharide did not affect the IC(50) of thrombin inhibition by a high affinity SBD, the presence of full-length heparin reduced inhibition potency by 4-fold. The presence of γ fibrinogen peptide, which recognizes Arg93, Arg97, Arg173, Arg175, and other residues, resulted in a loss of affinity that correlated with the ideal Dixon-Webb competitive profile. Replacement of several arginines and lysines of exosite 2 with alanine did not affect thrombin inhibition potency, except for Arg173, which displayed a 22-fold reduction in IC(50). Docking studies suggested a hydrophobic patch around Arg173 as a plausible site of SBD binding to thrombin. The absence of the Arg173-like residue in factor Xa ...
The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T and Treprese
80592-86-5 - ZLZINPAIXXXARB-UHFFFAOYSA-N - Benzofuran, 5-bromo-2-(diethylaminomethyl)-3-phenyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Experimental studies have shown that dioxin-like chemicals may interfere with aspects of the endocrine system including growth. However, human background population studies are, however, scarce. We aimed to investigate whether early exposure of healthy infants to dioxin-like chemicals was associated …
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A total number of 120 healthy subjects (with an approximate 1:1 female:male ratio) are planned to be randomised.. Day 1: a baseline ECG profile. Day 1: Group 1 will receive prucalopride, Group 2a will receive moxifloxacin, and Group 2b will receive placebo.. On Day 5 (steady-state level is reached), a full ECG assessment day will be performed, enabling the comparison of prucalopride 2 mg with placebo.. Subsequently, the number of tablets will be escalated in all groups (blinded) with 1 tablet a day up to 5 tablets.. On Day 13 (steady state for the supratherapeutic dose level of 10 mg of prucalopride) another ECG assessment day will be performed, enabling a comparison of prucalopride 10 mg with placebo.. Group 2b will receive a single dose of moxifloxacin on Day 15. All subjects will be discharged on Day 16. Subjects will remain in the CRU throughout the treatment period.. All subjects will return for a follow-up visit on Day 30 (± 1 week) (approximately 14 days after the last dose). ...
Pharmacyclics, Inc. (Nasdaq: PCYC) today announced interim data from a Phase I study of their novel orally administered Brutons tyrosine kinase (Btk) inhibitor PCI-32765 in patients
Mycoremediation, or fungus-based remediation, is an ex situ form of bioaugmentation, in which hazardous organics are degraded or detoxified by fungi that are introduced into the contaminated soil via a fungal inoculum. Due to the ability of white-rot fungi (WRF) to degrade extremely recalcitrant contaminants (e.g., high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), work on fungus-based remediation has focused on the treatment of soils contaminated with these types of chemicals. In addition, work has progressed on the soil microbiology of mycoremediation and on the development of techniques to monitor the fate of fungi inoculated into soils. Fallout of PCDDs and PCDFs from combustion at incineration facilities has resulted in serious pollution of the surrounding soil environment because of their extremely high persistence and toxicity. Importantly, the extent of the enhancement varied with soil and
Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide 433252-24-5 MSDS report, Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide MSDS safety technical specifications search, Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide safety information specifications ect.
Benzofuran-3(2H)-one 7169-34-8 MSDS report, Benzofuran-3(2H)-one MSDS safety technical specifications search, Benzofuran-3(2H)-one safety information specifications ect.
This is a Phase 2 multicenter, randomized, double-blind, placebo-controlled, add-on study of NBP softgel capsules for the treatment of mild to moderate cortical
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Vizard, C. G., Rimmer, D. L., Pless-Mulloli, T., Singleton, I., & Air, V. S. (2006). Identifying contemporary and historic sources of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in an industrial urban setting. Science of the Total Environment, 370(1), 61 - 69. https://doi.org/10.1016/j.scitotenv.2006.06.006. ...
We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. This recyclable catalyst could be reused more than 5 times in the same heteroannulation reaction. The results have demonstrated that diverse 2-substituted benzofurans with tolerant functional groups can be prepared simply and conveniently under these conditions ...
Exposure to chlorinated dibenzo-p-dioxins (CDDs) (75 chemicals) occurs mainly from eating food that contains the chemicals. One chemical in this group, 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,3,7,8-TCDD, has been shown to be very toxic in animal studies. It causes effects on the skin and may cause cancer in people. This chemical has been found in at least 91 of 1,467 National Priorities List sites identified by the Environmental Protection Agency (EPA).
You are viewing an interactive 3D depiction of the molecule 6-methoxy-3-methyl-n-phenyl-n-[3-(1-piperidinyl)propyl]-1-benzofuran-2-carboxamide (C25H30N2O3) from the PQR.
N-(2-Fluorophenyl)-4-[5-[(3-methyl-1-benzofuran-2-carbonyl)amino]pyridin-2-yl]piperazine-1-carboxamide | C26H24FN5O3 | CID 52917631 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Structure, properties, spectra, suppliers and links for: Methyl {[(2Z)-3-oxo-2-(2,3,4-trimethoxybenzylidene)-2,3-dihydro-1-benzofuran-6-yl]oxy}acetate.
1-[(5-Nitro-2-phenyl-1-benzofuran-3-yl)methyl]piperidine | C20H20N2O3 | CID 558839 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
8-[5-(diethylamino)pentylamino]quinolin-6-ol,8-[5-(propan-2-ylamino)pentan-2-ylamino]quinolin-6-ol,8-(5-azanylpentylamino)quinolin-6-ol,8-acetamidooctadecanoic acid,8-heptylselanyloctanoic acid,8-methyl-3-phenyl-1,4-dioxaspiro[4.5]decane,8-methyl-5-nitro-quinoline,8-[bis(2-hydroxyethyl)amino]-1,3-dimethyl-7H-purine-2,6-dione,8,10-bis(oxidanylidene)-9-azaspiro[5.5]undecane-11-carbonitrile,8-fluoranylbenzo[e][2]benzofuran-1,3-dione,8-fluoranyl-4,5-dihydrobenzo[e][2]benzofuran-1,3-dione,8-fluoranyl-3,3-diphenyl-benzo[g][2]benzofuran-1-one,8-[[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]methoxymethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-chloranyl-7-(chloromethyl)-1,3-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)aminomethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[bis(2-chloroethyl)aminomethyl]-3,7-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)amino]-3,7-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)amino]-1,3-dimethyl-7H-purine-2,6-dione,8-(diethylaminomethyl)-1,3,7-trimethyl-purine-2,6-dione,8
Compositional information provided by the Sponsor indicated the presence of a number of isomers of the test item (2,6-dimethyl-3a-(propan-2-yl)octahydro-1-benzofuran), which in total represent the reported purity for this substance. Using this information, the calculation of the test item water solubility was calculated based on the total peak area of all peaks obtained on chromatographic analysis which were attributed to these isomers of the test item. On comparison of the relative peak/isomer responses for the test item standard and sample solutions, there was no evidence of significant selective solubility/extractivity, with all test item peaks/isomers being detected, at a similar ratio, on analysis of the water solubility sample solutions ...
4B11: Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H(3) receptors, with K(i) values of 0.1-5.8 nM. Analogues were discovered with potent (0.01-1 mg/kg) cognition and attention enhancing properties in animal models. On …
Sigma-Aldrich offers abstracts and full-text articles by [Yibin Xiang, Bradford Hirth, Gary Asmussen, Hans-Peter Biemann, Kimberly A Bishop, Andrew Good, Maria Fitzgerald, Tatiana Gladysheva, Annuradha Jain, Katherine Jancsics, Jinyu Liu, Markus Metz, Andrew Papoulis, Renato Skerlj, J David Stepp, Ronnie R Wei].
I knew an old boy who mounted a barrel behind the axle on his old Farmall so he could take his kid to the field with him and not worry about losing him to a tragic run-over accident. I bet he knew someone who lost a child that way. When riding the fender, axle, or a parents lap, a kid can fall forward and be run over by the rear wheel of a tractor. It does happen! Passengers should not be riding on tractors unless modifiations are added to make it safe. Families never really recover from tragedies that kill their kids, and the emergency personnel that have to clean up the aftermath carry those images in their heads, too. Kids are precious, and cant be replaced, so dont do what this guy is doing, and that goes for your riding lawnmower, too ...
May and friends are walking through the woods when they find a wounded Swablu. Swablu puts the kids to sleep with Sing, but Torchic wakes them up by pecking their noses.
The Yankees have decided, as expected, to start the ALDS on Wednesday instead of Thursday to get the day of rest between Game 1 and 2.. As for the rotation, it will be CC Sabathia in Game 1 followed by A.J. Burnett and Andy Pettitte. Thats a little bit of a surprise considering Burnett would get the nod for Game 5 instead of Pettitte who has always been a big-game pitcher for the Yankees.. However, Burnett is pretty comfortable at home and Pettitte doesnt get rattled on the road.. ...
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There are 11 thirteen-letter words containing A, F, N, U and Z: DEFEUDALIZING DIBENZOFURANS FEUDALIZATION ... PARAINFLUENZA SULFADIAZINES UNFEUDALIZING. Every word on this site can be played in scrabble. See other lists, starting with or ending with letters of your choice.
Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). In this study, we analyzed the effects of DSU, SAB and a S. miltiorrhiza extract (SME) on cell proliferation. Additionally, the effects of DSU and SAB on collagen synthesis in Detroit 551 human normal fibroblast cells and on melanin production in B16 melanoma cells were verified. The results demonstrated that SME can enhance the proliferation of Detroit 551 cells and that this boost may be caused by DSU and SAB. This research showed that SME, DSU and SAB all have the ability to increase the production of collagen in Detroit 551 cells. The results also confirmed that DSU and SAB can attenuate the α-MSH-stimulated melanin production of B16 cells by inhibiting tyrosinase activity. Therefore, SME, DSU and SAB each have the potential to be utilized as active ingredients in wound healing or cosmetic treatments. In the future, DSU and SAB could also be used as functional components
Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
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ABSTRACTThe annual variations of wet deposition of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in atmosphere were measured at two sites (A and B) near two municipal solid waste incinerators (MSWIs) in southern Taiwan. Results showed that particle scavenging dominates in the wet deposition processes for the removal of PCDD/Fs from the atmosphere, the highest value was observed at the highest chlorinated congener. The ambient temperature and the amount of precipitation played an important role in the variation of PCDD/F deposition fluxes. It was found that temperature was inversely associated with the existence of particulate PCDD/Fs, indicating PCDD/Fs are scavenged most efficiently in cold weather. PCDD/F wet deposition fluxes in rainy seasons (from June to August) were significantly higher than those in dry seasons (from December to February), revealing a positive relationship between wet deposition flux and monthly rainfall. Additionally, the annual total (dry + wet) deposition
Results of recent studies showed that 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are equipotent in domestic chicken (Gallus gallus domesticus) while PeCDF is more potent than TCDD in ring-necked pheasant (Phasianus colchicus) and Japanese quail (Coturnix japonica). To elucidate the mechanism(s) underlying these differences in relative potency of PeCDF among avian species, we tested the hypothesis that this is due to species-specific differential binding affinity of PeCDF to the aryl hydrocarbon receptor 1 (AHR1). Here, we modified a cell-based binding assay that allowed us to measure the binding affinity of dioxin-like compounds (DLCs) to avian AHR1 expressed in COS-7 (fibroblast-like cells). The results of the binding assay show that PeCDF and TCDD bind with equal affinity to chicken AHR1, but PeCDF binds with greater affinity than TCDD to pheasant (3-fold) and Japanese quail (5-fold) AHR1. The current report introduces a COS-7 whole-cell binding ...
In vitro analysis of polychlorinated biphenyls (PCBs) and 2,3,4,7,8-pentachlorodibenzofuran (PCDF) cellular toxicity in PLC/PRF/5 cell proliferation--the effect of ursodeoxycholic acid, inchin-gorei-san and shou-saiko-to on cell toxicity.
Mass spectrometry/mass spectrometry (MS/MS) has been shown to be useful in the analysis of environmental samples for low (ppt) levels of compounds like polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in cases where interfering materials present in the samples made analysis by high resolution mass spectrometry (HRMS) difficult or impossible. While the technique shows promise because of its high selectivity, researchers have reported stability problems with mass spectrometry/mass spectrometry instruments and other questions regarding the reproducibility of analytical results exist. This study was undertaken to develop an MS/MS method for the analysis of PCDD/Fs, determine the stability of an MS/MS instrument over a period of months and to compare analytical results obtained by MS/MS with those obtained by HRMS. The results demonstrated that by following the protocol developed in the study, an MS/MS instrument can generate reproducible analytical results over a period of months and ...
Title: Dronedarone: A Safety Comparison to Amiodarone. VOLUME: 5 ISSUE: 3. Author(s):James R. Clem, Debra K. Farver, Janet R. Fischer and Thomas J. Johnson. Affiliation:South Dakota State University College of Pharmacy, 4801 North Career Avenue, Sioux Falls, SD 57107, USA.. Keywords:Dronedarone, SR 33589, amiodarone, atrial fibrillation, safety. Abstract: Dronedarone is an oral Class III antiarrhythmic agent which was recently approved by the US Food and Drug Administration for use in nonpermanent atrial fibrillation. Structurally similar to amiodarone, dronedarone is a benzofuran derivative but it lacks the iodine moiety attached to amiodarone. Based upon the investigational clinical trials to date, it appears that dronedarone has an established efficacy when compared to placebo along with exhibiting a minimal adverse effect profile. The efficacy of dronedarone will need to be further evaluated in comparison trials with established antiarrhythmics for atrial fibrillation. The adverse profile of ...
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) DATE: 07/14/03 EXPERIMENT: 96007 TEST: 05 TIME: 14:21:29 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C96007F ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: BATTELLE COLUMBUS TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) DATE: 07/14/03 EXPERIMENT: 96007 TEST: 05 TIME: 14:35:48 SPECIES: RATS, SPRAGUE-DAWLEY TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 96007F CONT: NO1-ES-75411 CAS: 57117-31-4 MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) ...