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Gestational urinary BPA concentrations were associated with some neurobehavioral measures at 3 years of age in this cohort. In particular, gestational BPA exposure was associated with higher scores for measures of anxiety, hyperactivity, emotional control, and behavioral inhibition. Similar to our previous findings, the effects of gestational BPA exposure on these behavioral domains were larger among girls than boys.2 The different responses to gestational BPA exposure were especially pronounced for hyperactivity; girls exhibited increases in hyperactivity, and boys exhibited decreases in hyperactivity. In contrast, childhood urinary BPA concentrations were less important predictors of behavior or executive functions in this study.. The findings presented are consistent with numerous studies demonstrating altered neurobehavior among BPA-exposed animals.14,38 Gestational BPA exposures might affect endocrine or other neurotransmitter pathways and disrupt sexual differentiation of the brain, to ...
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NIEHS Grant P30ES000002. A study, supported in part by the NIEHS, identified medical devices as a potential source of exposure to bisphenol A (BPA) among premature infants in neonatal intensive care units. BPA is used to manufacture polycarbonate plastics, which are used in medical devices such as intravenous administration sets, syringes, and catheters. The researchers looked at the urinary BPA concentration for 55 infants and categorized each infants medical device use as low or high based on the number and invasiveness of devices. They found that the median urinary total BPA concentration of infants who had required four or more medical devices for three previous days was significantly higher, 36.6 micrograms per liter (µg/l), than for the infants requiring three or less devices, who had a BPA concentration of 13.9 µg/l. The researchers also collected and analyzed breast milk or formula samples, and found that the increased BPA concentration was not associated with the infants nutritional ...
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It is in your food containers, water bottles, and 90 percent of us have it in our bloodstream. It may also be a prime candidate for causing wheezing in children if pregnant mothers come into contact with it. Experimental research in bisphenol A, (BPA) suggests that prenatal BPA exposure causes asthma in mice. No firm data yet exists for humans but results are not looking good.. Adam Spanier, M.D., Ph.D., assistant professor of pediatrics at Penn State College of Medicine, studied 367 children, 99 percent of whom were born to mothers who had detectable BPA levels during pregnancy. Twice a year for three years, the parents reported back with any signs of wheezing in the children. At six months of age, twice as many children were reported with wheezing from mothers who had higher BPA than those who had mothers with lower BPA levels. These effects may have diminished as the children aged however.. Researchers then looked at the levels of BPA in the women during certain times of their pregnancies and ...
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The main objective of this research project is to understand how in utero Bisphenol A (BPA) exposure affects fetal gonadal development and reproduction in adulthood in mice. In utero exposure to estrogenic endocrine disruptors such as diethylsfilbestrol (DES) is known to cause sex organ malformation, reproductive carcinogenesis, and fertility defects in both male and female in humans and rodents. Based on DES studies, it is proposed that in utero exposure to other endocrine disruptors, particularly those that work through estrogen receptors, may lead to reproductive diseases in adulthood. BPA, a chemical used in synthesis of plastics, exhibits estrogenic activities and deleterious effects on reproduction when given to adult rodents. BPA is detected in serum of pregnant women, umbilical cord blood, and fetal plasma, indicating that developing fetuses are exposed to BPA. Although effects of BPA on adult reproductive organs have been studied extensively, impacts of in utero BPA exposure ...
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NIEHS Grants: R01ES016541, P01ES022844, P30ES017885, R01ES017005, R01ES017005, R01ES016001, R01ES017524. NIEHS grantees report that exposure to the endocrine-disrupting chemical bisphenol A (BPA) during pregnancy can cause oxidative damage that may increase a childs risk of developing diabetes or heart disease later in life. The researchers tested multiple species of animals to replicate and strengthen human studies that showed BPA exposure during pregnancy can bring about a specific type of oxidative stress.. Oxidative stress is associated with insulin resistance and inflammation, which are risk factors for diabetes and other metabolic disorders as well as cardiovascular disease. For the human study, the researchers analyzed blood samples from 24 mother and infant pairs. The women were divided into two groups based on their levels of BPA determined from blood draws taken during their first trimester of pregnancy. Mothers and their infants with higher levels of BPA showed increased levels of ...
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Possible link between high prenatal BPA levels and neonatal neurobehavioral abnormalities; study advises pregnant women to reduce exposure levels. A new case study examining an infants neurobehavioral abnormalities and extremely high bisphenol A (BPA) concentration of the babys mother suggests a link between the two. The study, Environmental Health Perspectives: A Case Study of High Prenatal Bisphenol A Exposure and Infant Neonatal Neurobehavior, was led by researcher Sheela Sathyanarayana, MD of Seattle Childrens Research Institute, and recently published online in Environmental Health Perspectives.. BPA, a synthetic, man-made chemical, is used in a wide variety of products including: can linings; hard polycarbonate plastics such as baby bottles and reusable cups; and dental sealants. Food may be the single largest source of BPA exposure due to contamination of foods during preparation and processing. BPA has estrogenic (hormone-like) properties. In animal studies, exposure to BPA early in ...
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Arnold J. Schecter and colleagues note that BPA is used in lining metal cans and in polycarbonate plastics such as baby bottles, although some manufacturers are switching to BPA-free products. "In humans, BPA is associated with cardiovascular disease, diabetes, and male sexual dysfunction in exposed workers," they state. "Food is a major exposure source. We know of no studies reporting BPA in U.S. fresh food, canned food, and food in plastic packaging in peer reviewed journals." To fill that gap in scientific knowledge, the scientists measured BPA levels in 105 human, cat, and dog foods. They detected BPA in 63 of 105 human food samples from grocery stores in Dallas, and present a detailed list of foods, brands, and BPA levels in the text of the study. The levels were lower than the 50 micrograms per kilogram of body weight standard used by EPA and EFSA and comparable to levels detected in the past. Schecter noted that some studies have shown adverse effects associated with exposure to BPA at ...
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An ongoing debate about the health impacts of bisphenol A (BPA), the ubiquitous chemical used in production of polycarbonate - that hard clear plastic we use for eating, drinking, and storing food - continues, according to a recent article by Janet Raloff published in the September 29 issue of Science News. Her analysis provides good insight into why we often hear conflicting reports when it comes to environmental and health impacts of chemicals.. Raloff reports on the conflicting results of two different panels recruited by the National Toxicology Program (NTP) and charged with reviewing and evaluating the potential developmental and reproductive impacts of BPA. While one panel "labeled as confident its assessment that BPA at low doses has had negative effects on experimental animals," and that such findings were suggestive of impacts in humans, the other panel "concluded that current BPA exposures appear to pose little risk to humans.". According to Raloff, one of the differences cited in ...
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The study conducted by researchers at the Harvard School of Public Health (HSPH) found that a group of volunteers who consumed a serving of canned soup each day for five days had a more than 1,000 percent increase in urinary bisphenol A (BPA) concentrations compared with when the same individuals consumed fresh soup daily for five days ...
The list of adverse health effects from BPA exposure continues to grow. Bisphenol A, or BPA, is commonly used to line food and beverage cans, and helps to keep plastics flexible, but studies suggest the compound can leach into the foods we eat.
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New research led by researchers at North Carolina State University shows that exposure to the chemical bisphenol A (BPA) early in life results in high levels of anxiety by causing significant gene expression changes in a specific region of the brain called the amygdala. The researchers also found that a soy-rich diet can mitigate these effects.. "We knew that BPA could cause anxiety in a variety of species, and wanted to begin to understand why and how that happens," says Dr. Heather Patisaul, an associate professor of biology at NC State and lead author of a paper describing the work. BPA is a chemical used in a wide variety of polycarbonate plastics and epoxy resins, and is used in consumer products such as some food containers.. In the study, rats were exposed to low doses of BPA during gestation, lactation (nursing) and through puberty. One group of animals was fed only soy; one group was fed a soy-free diet; one group was fed only soy and exposed to BPA; and one group was fed no soy and ...
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1945- L. J. HUMBERT 2,392,479 BEVERAGE CONTAINER Filed July 24, 1944 JNVENTOR. Laura J. HuMB RT I ATTORNEY Patented Jan. 8, 1946 UNITED STATES PATENT OFFICE BEVERAGE CONTAINER Louis J. Humbert, Wyandotte, Mich. Application July 24, 1944, Serial No. 546,363 Claims. This invention relates to beverage containers, and more particularly to a light and cheap form of such container wherein beverages of various kinds, such as milk, lemonade, and certain soft drinks, may be sealed for shipment and transportation and use on railway trains and the like, the container being provided with convenient means for enabling the purchaser or user to drin the contents thereof. r The prime object of the invention therefore is to provide in a suitably light and cheap form, a liquid container of the kind referred to, the same being made of water-proofed pasteboard or any other suitable material, and being provided with a pair of telescopically associated drinking tubes, also of cheap material, these tubes being ...
If you look at the research, though, there are a few reports of patients having severe insomnia for weeks or months after moderate doses of provigil. Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. Insomnia, decreased concentration, and. We evaluated the use of modafinil for treating. I did not have insomnia until last week. The most common side effects of the medication include headache, abdominal pain, insomnia, decreased appetite, nervousness and dizziness. To start viewing messages, select the forum that you want to visit from the selection below This reduces the early stopping provigil cold turkey and continued for buy provigil mastercard increased azole or the treatment with fever or low in the results. Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts. Cytokine, they inhibit distal small doses given as preven- tion Retains ...
In the study, maternal exposure to 10 micro g/ml of BPA in mice enhanced the allergic sensitization and bronchial inflammation and responsiveness in their pups. This dosage mimics the human BPA burden of chronic exposure, including that of pregnant women.. "Previous studies indicated that maternal exposure in mice to environmental BPA enhanced the susceptibility of their pups to allergic asthma," said study co-author Terumi Midoro-Horiuti, MD, PhD. "The goal of this study was to determine the actual threshold of the effects of BPA on allergic sensitization, airway inflammation and hyper-responsiveness.". Female mice received 0, 0.1, 1 and 10 micro g/ml of BPA in their drinking water from one week before pregnancy, during pregnancy and while nursing their pups, in the study conducted at The University of Texas Medical Branch at Galveston.. BPA is a chemical commonly found in polycarbonate plastic bottles and the aluminum lining of food and beverage cans. BPA production started about 40 years ago. ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Provigil contains a medication named Modafinil. It is known to have a stimulating effect on the brain, which helps to alleviate the sleepiness and keeps the person awake. It is not a curative drug but it facilitates the treatment of certain medical conditions related to sleep.. What does it do?. Provigil increases certain neurotransmitters (like dopamine, epinephrine, and serotonin) in the brain. These neurotransmitters have a stimulating effect on the brain and they keep a person awake.. What is it used for?. It is used in treating narcolepsy (a condition characterized by excessive sleep), Shift Work Disorder and sleep apnea (a condition characterized by frequent sleep disturbances due to the interruption in breathing while sleeping).. The dosage of Provigil:. For Narcolepsy and Sleep Apnea-200 mg orally, in the morning. For shift work disorder- 200 mg, orally in a day, 1 hour prior to the start of their work shift. Reduction in dosages is required for hepatic impairment and geriatric ...
Provigil is a brain enhancer which is used to treat the excessive sleep disorder. Provigil generic name is Modafinil. Provigil is a wakefulness promoting agent.
The chemical BPA, which makes plastic hard and clear, has been used in many consumer products such as reusable water bottles. It also is found in epoxy resins, which form a protective lining inside metal food and beverage cans.. "While preliminary, the data indicate the negative effect of BPA on reproductive health and the importance of allocating more funding to further investigate why such environmental contaminants might be disrupting fertility potential," said Victor Y. Fujimoto, MD, lead study author and professor in the UCSF Department of Obstetrics, Gynecology, and Reproductive Sciences, who also is on the faculty of the UCSF Center for Reproductive Health.. Findings are available online in the journal Fertility and Sterility at http://j.mp/fyjTFF.. In the study, BPA levels and fertilization rates were analyzed for 26 women undergoing IVF during 2007 and 2008 at the UCSF Center for Reproductive Health. The women were a subgroup of a larger study evaluating the effect on reproductive ...
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Exposure to the endocrine-disrupting chemical bisphenol A during pregnancy can cause oxidative damage that may put the baby at risk of developing diabetes or heart disease later in life, according to a new study published in the Endocrine Societys journal Endocrinology.
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Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological and behavioural research. To investigate the behavioural effects of modafinil on anxiety, we administered doses of 0, 2, 20, and 200 mg/L for 30 minutes then tested zebrafish in the novel approach test. In this test, the fish was placed into a circular arena with a novel object in the center and motion-tracking software was used to quantify the time the fish spent in the outer area of the arena (thigmotaxis zone), middle third of the arena (transition zone) and center of the arena, as well as total distance traveled, immobility and meandering. Modafinil caused a decrease in time spent in the thigmotaxis zone and increased time spent in the transition zone across all doses. Modafinil did not significantly
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Bisphenol A (BPA) is used in a wide variety of consumer products, and biomonitoring studies indicate widespread exposure to the compound. Much of the hesitation to regulate BPA up to now has stemmed from uncertainty about whether health effects reported in laboratory animals-which include heart disease, obesity, diabetes, reproductive health problems, and several types of cancer can be extrapolated to humans. In this podcast, Frederick vom Saal discusses recent findings that suggest mice, rhesus monkeys, and humans metabolize BPA at similar rates, raising the possibility that effects observed in animal models may be relevant to humans as well. Vom Saal is a Curators Professor of biology at the University of Missouri." ...
Current human exposure to bisphenol A (BPA), a chemical used in many polycarbonate plastics and epoxy resins, is of some concern for effects on development of the prostate gland and brain and for behavioral effects in fetuses, infants and children, according to a final report released today by the National Toxicology Program (NTP).
Background The National Health and Nutrition Examination Survey (NHANES) is one example of cross-sectional datasets that have been used to draw causal inferences regarding environmental chemical exposures and adverse health outcomes. Our objectives were to analyze four NHANES datasets using consistent a priori selected methods to address the following questions: Is there a consistent association between urinary bisphenol A (BPA) measures and diabetes, coronary heart disease (CHD), and/or heart attack across surveys? Is NHANES an appropriate dataset for investigating associations between chemicals with short physiologic half-lives such as BPA and chronic diseases with multi-factorial etiologies? Data on urinary BPA and health outcomes from 2003-2004, 2005-2006, 2007-2008, and 2009-2010 were available. Methodology and Findings Regression models were adjusted for creatinine, age, gender, race/ethnicity, education, income, smoking, heavy drinking, BMI, waist circumference, calorie intake, family history
This opinion describes the assessment of the risks to public health associated with bisphenol A (BPA) exposure. Exposure was assessed for various groups of the human population in three different ways: (1) external (by diet, drinking water, inhalation, and dermal contact to cosmetics and thermal paper); (2) internal exposure to total BPA (absorbed dose of BPA, sum of conjugated and unconjugated BPA); and (3) aggregated (from diet, dust, cosmetics and thermal paper), expressed as oral human equivalent dose (HED) referring to unconjugated BPA only. The estimated BPA dietary intake was highest in infants and toddlers (up to 0.875 µg/kg bw per day). Women of childbearing age had dietary exposures comparable to men of the same age (up to 0.388 µg/kg bw per day). The highest aggregated exposure of 1.449 µg/kg bw per day was estimated for adolescents. Biomonitoring data were in line with estimated internal exposure to total BPA from all sources. BPA toxicity was evaluated by a weight of evidence ...
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Most of us are aware that there are lots of dangerous materials like additives, dyes, pesticides and carcinogens in our foods. What many of us are not aware of is that in the containers that our foods come in, especially take out, there are chemicals in the materials that may be even more harmful than the additives, dyes and pesticides.. By now you have probably heard of the dangers of the toxic chemical Bisphenol A (BPA). This chemical can be found in polycarbonate plastic food containers, bottles and takeout food containers. Numerous articles have been written on breast cancer and prostate cancer that result from exposure to the BPA contained in packaging and containers that carry food stuffs.. Recent, important environmental health study findings were published in March in the online journal Environmental Health Perspectives. A study was conducted by two organizations concerned with the environmental causes of breast cancer, the Breast Cancer Fund and Silent Spring Institute. The study was on ...
Americans these days dont want artificial and unsustainably produced ingredients in the food they buy and eat. For the makers of highly processed foods - ultraprocessed in todays terminology - there isnt a lot that they can do to make the products appear fresh and natural.. But Campbells is certainly trying. A few months after announcing that it will phase out genetically modified organisms (GMOs), the iconic soup company said on Friday that it will remove Bisphenol-A (BPA) from its cans by next year.. BPA, you will recall, is a chemical typically used in polycarbonate plastic containers and in the epoxy linings of food cans. Its also an endocrine disrupter, which means it can interfere with the work our hormones are doing. Some research finds BPA to have effects on childhood development and reproduction.. Although the FDA doesnt believe evidence of potential harm is sufficient to ban BPA from the food supply, the agency discourages use of BPA-polycarbonate or epoxy resins in baby bottles, ...
Fatigue is a common problem for many people with HIV/AIDS, interfering with daily activities and serving as a significant barrier to working among those whose health is otherwise stable or restored by antiretroviral (ARV) medication. Fatigue in HIV is associated with disability and diminished quality of life. It may be caused by ARVs or by the virus itself. A related study tested whether modafinil, of which armodafinil is an r-isomer, could reduce fatigue in HIV/AIDS patients. Armodafinil, believed to have a longer duration and greater effect than modafinil, will be tested on the same criteria.. Participants will be randomly assigned to receive either armodafinil or a placebo daily for 4 weeks. Participants randomized to active medication and who show improvements in symptoms will be offered armodafinil for an additional 12 weeks. For them, the study duration is 16 weeks. Participants who did not receive armodafinil will be offered armodafinil for 16 weeks. For these participants, the study ...
Fatigue is a common problem for many people with HIV/AIDS, interfering with daily activities and serving as a significant barrier to working among those whose health is otherwise stable or restored by antiretroviral (ARV) medication. Fatigue in HIV is associated with disability and diminished quality of life. It may be caused by ARVs or by the virus itself. A related study tested whether modafinil, of which armodafinil is an r-isomer, could reduce fatigue in HIV/AIDS patients. Armodafinil, believed to have a longer duration and greater effect than modafinil, will be tested on the same criteria.. Participants will be randomly assigned to receive either armodafinil or a placebo daily for 4 weeks. Participants randomized to active medication and who show improvements in symptoms will be offered armodafinil for an additional 12 weeks. For them, the study duration is 16 weeks. Participants who did not receive armodafinil will be offered armodafinil for 16 weeks. For these participants, the study ...
Doctors prescribe modafinil, sold under the brand name Provigil, to improve wakefulness in adults who are experiencing excessive sleepiness.
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