In the current study, all infants had detectable urinary concentrations of total BPA, ranging from 2.0 to 196 µg/L. The median urinary BPA concentration in this group of premature infants was considerably higher (17.2 μg/L) than in healthy term infants aged 1 to 5 months (,0.45 μg/L) without known BPA exposure.21 Although immaturity of phase II metabolism may account for some of the association of urinary BPA concentrations with prematurity, premature infants have the ability to conjugate BPA.16 Interestingly, medical devices, but not nutritional intake, were positively associated with urinary BPA concentrations. On average, premature infants requiring ≥4 medical devices had urinary total BPA concentrations 1.6 times higher than those requiring fewer devices independent of their gestational age, gender, or nutritional intake. Respiratory devices were associated with higher urinary BPA concentrations than other devices. These findings suggest that medical devices were an important source of ...
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Gestational urinary BPA concentrations were associated with some neurobehavioral measures at 3 years of age in this cohort. In particular, gestational BPA exposure was associated with higher scores for measures of anxiety, hyperactivity, emotional control, and behavioral inhibition. Similar to our previous findings, the effects of gestational BPA exposure on these behavioral domains were larger among girls than boys.2 The different responses to gestational BPA exposure were especially pronounced for hyperactivity; girls exhibited increases in hyperactivity, and boys exhibited decreases in hyperactivity. In contrast, childhood urinary BPA concentrations were less important predictors of behavior or executive functions in this study.. The findings presented are consistent with numerous studies demonstrating altered neurobehavior among BPA-exposed animals.14,38 Gestational BPA exposures might affect endocrine or other neurotransmitter pathways and disrupt sexual differentiation of the brain, to ...
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NIEHS Grant P30ES000002. A study, supported in part by the NIEHS, identified medical devices as a potential source of exposure to bisphenol A (BPA) among premature infants in neonatal intensive care units. BPA is used to manufacture polycarbonate plastics, which are used in medical devices such as intravenous administration sets, syringes, and catheters. The researchers looked at the urinary BPA concentration for 55 infants and categorized each infants medical device use as low or high based on the number and invasiveness of devices. They found that the median urinary total BPA concentration of infants who had required four or more medical devices for three previous days was significantly higher, 36.6 micrograms per liter (µg/l), than for the infants requiring three or less devices, who had a BPA concentration of 13.9 µg/l. The researchers also collected and analyzed breast milk or formula samples, and found that the increased BPA concentration was not associated with the infants nutritional ...
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It is in your food containers, water bottles, and 90 percent of us have it in our bloodstream. It may also be a prime candidate for causing wheezing in children if pregnant mothers come into contact with it. Experimental research in bisphenol A, (BPA) suggests that prenatal BPA exposure causes asthma in mice. No firm data yet exists for humans but results are not looking good.. Adam Spanier, M.D., Ph.D., assistant professor of pediatrics at Penn State College of Medicine, studied 367 children, 99 percent of whom were born to mothers who had detectable BPA levels during pregnancy. Twice a year for three years, the parents reported back with any signs of wheezing in the children. At six months of age, twice as many children were reported with wheezing from mothers who had higher BPA than those who had mothers with lower BPA levels. These effects may have diminished as the children aged however.. Researchers then looked at the levels of BPA in the women during certain times of their pregnancies and ...
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The main objective of this research project is to understand how in utero Bisphenol A (BPA) exposure affects fetal gonadal development and reproduction in adulthood in mice. In utero exposure to estrogenic endocrine disruptors such as diethylsfilbestrol (DES) is known to cause sex organ malformation, reproductive carcinogenesis, and fertility defects in both male and female in humans and rodents. Based on DES studies, it is proposed that in utero exposure to other endocrine disruptors, particularly those that work through estrogen receptors, may lead to reproductive diseases in adulthood. BPA, a chemical used in synthesis of plastics, exhibits estrogenic activities and deleterious effects on reproduction when given to adult rodents. BPA is detected in serum of pregnant women, umbilical cord blood, and fetal plasma, indicating that developing fetuses are exposed to BPA. Although effects of BPA on adult reproductive organs have been studied extensively, impacts of in utero BPA exposure ...
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New Study from CCCEH Finds Exposure to Bisphenol-A in the Womb is Linked to Behavioral Problems in Young Children. NEW YORK (April 28, 2012) Over the past few years two new phrases have been introduced to our everyday language-bisphenol-A (BPA) and endocrine disrupting chemicals. According to a new study by researchers at Columbia Center for Childrens Environmental Health at the Columbia University Mailman School of Public Health, exposure to BPA in the womb may be linked to behavioral problems in young children.. The study was published in an advance online edition of Environmental Health Perspectives entitled Prenatal Bisphenol A Exposure and Child Behavior.. BPA is found in many products we use every day, ranging from polycarbonate plastics like those used in food and beverage storage containers, the lining of canned food and beverages, thermal paper cashier receipts, to dental sealants. As a result of the high volume production and use, the majority of Americans are exposed to BPA. ...
NIEHS Grants: R01ES016541, P01ES022844, P30ES017885, R01ES017005, R01ES017005, R01ES016001, R01ES017524. NIEHS grantees report that exposure to the endocrine-disrupting chemical bisphenol A (BPA) during pregnancy can cause oxidative damage that may increase a childs risk of developing diabetes or heart disease later in life. The researchers tested multiple species of animals to replicate and strengthen human studies that showed BPA exposure during pregnancy can bring about a specific type of oxidative stress.. Oxidative stress is associated with insulin resistance and inflammation, which are risk factors for diabetes and other metabolic disorders as well as cardiovascular disease. For the human study, the researchers analyzed blood samples from 24 mother and infant pairs. The women were divided into two groups based on their levels of BPA determined from blood draws taken during their first trimester of pregnancy. Mothers and their infants with higher levels of BPA showed increased levels of ...
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Possible link between high prenatal BPA levels and neonatal neurobehavioral abnormalities; study advises pregnant women to reduce exposure levels. A new case study examining an infants neurobehavioral abnormalities and extremely high bisphenol A (BPA) concentration of the babys mother suggests a link between the two. The study, Environmental Health Perspectives: A Case Study of High Prenatal Bisphenol A Exposure and Infant Neonatal Neurobehavior, was led by researcher Sheela Sathyanarayana, MD of Seattle Childrens Research Institute, and recently published online in Environmental Health Perspectives.. BPA, a synthetic, man-made chemical, is used in a wide variety of products including: can linings; hard polycarbonate plastics such as baby bottles and reusable cups; and dental sealants. Food may be the single largest source of BPA exposure due to contamination of foods during preparation and processing. BPA has estrogenic (hormone-like) properties. In animal studies, exposure to BPA early in ...
Welcome to Californias Beverage Container Recycling Program. Whether youre a consumer who wants to redeem your empty bottles and cans for cash, a recycling center operator who needs the latest industry updates, or anyone else with an interest in beverage container recycling, youll find the information you need on these pages. CalRecycle, officially known as the Department of Resources Recycling and Recovery, administers the California Beverage Container Recycling and Litter Reduction Act. Beverage containers covered under the act are subject to California Redemption Value (CRV), which is 5 cents for containers less than 24 ounces, 10 cents for containers 24 ounces or larger. Thanks to the CRV cash incentive, more than 300 billion aluminum, glass, and plastic beverage containers have been recycled since the program began in 1987.. Many communities in California now offer curbside collection in addition to beverage container recycling centers. To find your closest recycling center, check out ...
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Washington, D.C.-On March 29, the Environmental Protection Agency (EPA) released a bisphenol-A (BPA) action plan to assess the environmental impacts of the chemical and to require testing of its environmental effects. Earlier this year, the U.S. Food and Drug Administration (FDA) publicly announced its concern over the presence and detrimental health effects of BPA in food packaging and in the environment.. As published in WholeFoods Magazines March 2010 issue, BPA present in polycarbonate plastic is an endocrine disruptor. The U.S. National Toxicology Program reported some concern for effects on the brain, behavior, and prostate gland in fetuses, infants and children at current human exposures to [BPA]. Other studies show the carcinogenic effects of the compound.. Steve Owens, assistant administrator of EPAs Office of Prevention, Pesticides and Toxic Substances stated, We share FDAs concern about the potential health impacts from BPA…Both EPA and FDA, and many other agencies, are moving ...
Humans tend to be exposed to bisphenol A (BPA), the monomer of polycarbonate plastics and epoxy resins, through BPA contaminated drinking water, beverages and foods, packaged in polycarbonate plastic bottles and cans coated with epoxy resins due to leaching. [[17], [18], [19]]. When human being becomes exposed to BPA then the circulating level of BPA has been found in the 10C100?nM range [20,18]. Bisphenol F (BPF) and Bisphenol S (BPS) were also frequently recognized in human body [21]. Elevated concentrations of BPF, and BPS G15 (i.e., much like or greater than that of BPA) have been reported in the abiotic environment and in some areas the daily intake ideals G15 of BPS in different countries ranges from 0.023 to 1 1.67?g/person while obtained from human being urine sample [22]. Duodenal clean muscles motor functions have been inhibited by BPA. Generation of oxidative stress, decreasing the availability of free Ca2+, inducing the activity of acetylcholinesterase (AChE) and advertising of the ...
The primary objective of the study is to evaluate the safety and tolerability of treatment with PROVIGIL in children and adolescents with excessive sleepiness (ES) associated with narcolepsy or OSAHS (obstructive sleep apnea/hypopnea), when administered for up to 12 months. Safety and tolerability will be evaluated throughout the study by means of adverse event information, clinical laboratory test results, vital signs measurements, and body weight and height measurements; quarterly physical examination findings; and 12 lead electrocardiograph (ECG) evaluations at the end of the study. In addition, the cognitive and behavioral effects of PROVIGIL will be assessed quarterly as measured by the Child Behavior Checklist for Ages 6-18 (CBCL/6-18), a brief psychiatric interview, and the Kaufman Brief Intelligence Test (KBIT 2 ...
background: This study aimed to determine serum Bisphenol A (BPA) concentrations in patients with dilated cardiomyopathy (DCM) as well as the association between serum BPA and several hormonal parameters in DCM patients compared with a healthy control group. Materials and methods: Eighty-eight DCM patients and 88 age- and gender-matched healthy controls were included. Serum BPA levels and several hormonal parameters (including total testosterone (T), sex hormone-binding globulin (SHBG) and estradiol (E2) were measured by using corresponding ELISA Kits. The free androgen index (FAI) was calculated by the formula: total T in nmol/L × 100/SHBG in nmol/L. Results: BPA levels in the total DCM group were significantly higher compared with that in the controls (6.9 ± 2.7 ng/mL vs. 3.8 ± 1.9 ng/mL, p < 0.001). Significant difference was also observed in SHBG and FAI between DCM patients and controls, (76.9 ± 30.9 nM/L vs. 41.0 ± 15.6 nM/L and 2.9 ± 3.5 vs.5.3 ± 2.6, respectively, both of p < 0
Introduction: Octylphenol (OP) is a degradation product of alkylphenol ethoxylates that are widely used to in rubber, pesticides and paints. Bisphenol A (BPA) is an organic compound with two functional phenol groups and used to make polycarbonate plastic and epoxy resins, along with other applications. OP and BPA are known as endocrine disruptors that can induce inappropriate estrogenic action, and may disturb natural calcium metabolism. In the present study, the effects of OP and BPA on the calcium levels of serum and urine, and calcium transport genes were investigated in the duodenum, kidney and placenta of the pregnant mice.. Methods: From 6.5 to 16.5 days after post coitus (dpc), pregnant mice were orally given with ethylestradiol (EE, 0.2 mg/kg/day), OP (15, 45, or 135 mg/kg/day) or BPA (5 or 50 mg/kg/day) dissolved in corn oil. The duodenum, kidney, placenta, blood and urine were obtained from mice at day 18.5 of pregnancy.. Results: As a result, serum and urinary calcium levels were ...
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IARC 1999 17 Opinion of the Scientific Panel on Food Additives Flavourings Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to 2 2-bis(4-hydroxylphenyl)propane bis(2 3-epoxypropyl)ether (Bisphenol A diglycidyl ether BADGE) The EFSA Journal No 86 2004 adopted July 13 2004 page 1 18 Draft International Uniform Request A Quotation! ...
BEVERAGE CONTAINER PACKAGE AND DISPENSER - A package for a number of beverage containers includes an overlay member covering the top ends of the beverage containers. The overlay member has a central, generally planar panel positioned atop the top ends of the beverage containers and a number of perimeter panels each joined to and positioned on a perimeter of the central panel. Each perimeter panel is oriented generally perpendicularly relative to the central panel. A dispenser opening is in the central panel of the overlay member through the beverage containers may be removed from the package. A dispenser flap is adjacent the dispenser opening and a perimeter edge of the overlay member. The dispenser flap may be pulled outwardly from the overlay member by a user to provide access through which the beverage containers may be removed from the package. An overwrap member such as a thermoplastic shrink wrap film envelops the array of beverage containers and the overlay member to provide a robust, ...
Poly(ethylene glycol) diglycidyl ether (n ~22; also known as PEGDE) is a difunctional, water-soluble crosslinker for amine-, hydroxyl-, and carboxyl-functional polymers. Learn More ...
The use of p tris 2 aminoethyl amine co glycerol diglycidyl ether microgel as template for Co Ni nanoparticles and their use as catalyst for H2 production from NaBH4 hydrolysis ...
Psychopharmacological modulation of the catecholaminergic system can enhance some aspects of cognitive function. For example, COMT inhibitors can slightly improve working memory/executive function. Similarly, modafinil, a catecholaminergic agonist that increases extracellular dopamine in the prefrontal cortex was also shown to improve delay-dependent working memory. Differences in the response between individuals might be related to a number of factors, including variations in the genes. The recent finding that a polymorphism in the catechol-o-methyl-transferase (COMT) gene, which produces a 4 fold change in enzyme activity, accounts for 4% of the variance in performance of working memory tasks in humans suggest that COMT genotype may predict response to COMT inhibitors or to other agonists that increase catecholaminergic function in the frontal cortex.. In the present investigation our goal is to examine, in normal controls and patients with schizophrenia, the effect of modafinil, a drug that ...
The mechanism of action of armodafinil is unknown. Armodafinil (R-(−)-modafinil) has pharmacological properties almost identical to those of modafinil (a mixture of R-(−)- and (S)-(+)-modafinil). The (R)- and (S)-enantiomers have similar pharmacological action in animals. Armodafinil has wake-promoting actions similar to sympathomimetic agents including amphetamine and methylphenidate, although its pharmacologic profile is not identical to that of the sympathomimetic amines. Armodafinil is an indirect dopamine receptor agonist; it binds in vitro to the dopamine transporter (DAT) and inhibits dopamine reuptake. For modafinil, this activity has been associated in vivo with increased extracellular dopamine levels. In genetically engineered mice lacking the dopamine transporter, modafinil lacked wake-promoting activity, suggesting that this activity was DAT-dependent. However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor ...
In recent years, numerous substances have been identified as so-called endocrine disruptors because exposure to them results in disruption of normal endocrine function with possible adverse health outcomes.. The pathologic and behavioral abnormalities attributed to exposure to endocrine disruptors like bisphenol-A (BPA) have been studied in animals. Mental conditions ranging from cognitive impairment to autism have been linked to BPA exposure by more than one investigation. Concurrent with these developments in BPA research, schizophrenia research has continued to find evidence of possible endocrine or neuroendocrine involvement in the disease.. Sufficient information now exists for a comparison of the neurotoxicological and behavioral pathology associated with exposure to BPA and other endocrine disruptors to the abnormalities observed in schizophrenia.. This review summarizes these findings and proposes a theory of endocrine disruption, like that observed from BPA exposure, as a pathway of ...
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Gene Expression Profiling Analysis of Bisphenol A-Induced Perturbation in Biological Processes in ER-Negative HEK293 Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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A recent study in a preclinical model of inflammatory bowel disease shows dietary exposure to bisphenol-A, or BPA, found in polycarbonate plastics and epoxy resins, can increase mortality and worsen its symptoms.
Benzhydryl compounds are compounds that are diphenylmethane-containing, i.e. containing two benzene rings adjoining a single methyl radical. This does not include compounds where these benzenes are fused to other rings.[1] Benzhydryl can be abbreviated to CHPh2 or Bzh.[2] ...
A newer medication called Provigil (Modafinil), which is used to promote wakefulness (eugeroic), has also been found to help manage symptoms of ADHD. Many
Last year, Breast Cancer UK awarded a research grant to Dr Michael Antoniou, along with his research associate Dr Robin Mesnage, at Kings College London, to evaluate the endocrine disrupting properties of herbicides and compounds used to make plastics. In this science blog, Dr Mesnage explains the background to their most recent findings which have just been published as a preprint. More than 80 years ago, bisphenol A (BPA) was discovered to have oestrogen hormone mimicking effects. Discarded by the pharmaceutical industry, it was nonetheless used as a plasticizer and added to polycarbonate plastic or epoxy resins for decades, before some researchers rediscovered its ability to disturb the hormonal system. Thousands of studies are now reporting adverse health effects of BPA in humans, including reproductive and neurobehavioural disorders. Due to mounting evidence of harm and public pressure, BPA is being phased out by plastics manufacturers and BPA-free products are now found in ...
Bisphenol A (BPA) is one of the most prevalent chemicals in many products used on a daily basis, making human exposure to it incredibly pervasive and raising concerns about its health consequences. One area of research focus has been the role of BPA exposure in promoting the development of ovarian cancer; however, the doses used in most of previous studies are relatively high and most likely exceed physiologically relevant levels. At the same time, few studies have described potential mechanisms underlying the link between BPA and increased cancer risk. To address these concerns, the authors investigated the mechanism(s) by which low concentrations of BPA promote proliferation and energy metabolism in the human ovarian cancer cell line OVCAR-3. The results showed that even sub-toxic BPA concentrations not only drove increased OVCAR-3 cell proliferation but also promoted glycolysis-based metabolism, as evidenced by elevated cell viability, accelerated cell proliferation, increased levels of ...
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The impact of exposures during two developmental windows - the prenatal and the adolescent periods - will be assessed. At the heart of the research will be two human cohort studies - a pilot birth cohort in Urbana-Champaign, IL (Project 1;S.Schantz, PI) and a pilot adolescent cohort to be studied in the context of an ongoing study in New Bedford, MA (project 2; S. Korrick, PI). These studies will assess the relation of BPA or phthalate exposure to sexually dimorphic aspects of physical development and cognition in newborn infants and cognition in adolescent. This Center includes animal studies that will model the timing of exposure in the human cohorts. These studies will investigate mechanisms through which BPA disrupts male and female gonad development using transgenic (with genes from other organisms) and knockout (with specific genes deactivated) mouse models (Project 3; H. Yao, PI), and the impact of in utero or peripubertal BPA exposure on development of sexually dimorphic cortical brain ...
Lawyers are accepting cases involving birth defects in children whose mothers took Provigil (modafinil) or Nuvigil (armodafinil) while pregnant.
A beverage container provided with unique pressure relief valve means designed to permit the escape of gaseous pressure that may build up within the container as through the inclusion of dry ice therein. The container also includes an interior container which is raised from the bottom of the primary container and includes interior finger-pull abutments. The inner container is designed for slipping downwardly into the interior of the outer container only a predetermined distance, this before a wedging effect occurs; thus, the bottom of the inner container is spaced above the bottom of the outer container so as to lessen chances of fracturing or cracking of the bottom of the outer container when dry ice is disposed in the inner container.
Well, not quite. But in recent years researchers have been exploring the potential of using biochar to remediate soil contaminated with organic chemicals. Similar to but definitely not the charcoal commonly used during barbecue season, biochar is made by heating biomass such as fruit peels in oxygen-limited conditions. Its physical and chemical characteristics impart an exceptional ability to sorb chemicals, especially organic chemicals, and reduce their bioavailability in soil.. A new study by Xu and co-workers at Peking University and the Chinese Academy of Agricultural Sciences focuses on two widespread organic chemicals: bisphenol A (BPA) and 17α-ethylyneestradiol (EE2). BPA is used for manufacturing polycarbonate plastics and epoxy resins. Thus, it is found in a multitude of commonly used products such as cars, food storage containers, and electronic equipment. EE2 is a synthetic estrogen most commonly used as an ingredient in birth control pills.. Both of these chemicals have been found ...