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Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and discussed in this review. Kupffer discovered black-stained cells in the liver using the gold chloride method and named them stellate cells (Sternzellen in German) in 1876. Wake rediscovered the cells in 1971 using the same gold chloride method and various modern histological techniques including electron microscopy. Between their discovery and rediscovery, HSCs disappeared from the research history. Their identification, the establishment of cell isolation and culture methods, and the development of cellular and molecular biological techniques promoted HSC research after their rediscovery. In mammals, HSCs exist in the space between liver parenchymal cells (PCs) or hepatocytes and liver sinusoidal endothelial cells (LSECs) of the hepatic lobule, and store 50-80% of all vitamin A in the body as retinyl ester in lipid

A diagnosis of acute otitis externa (AOE) requires sudden onset (e.g., within 48 hours) within the past three weeks of symptoms (e.g., otalgia, itching, fullness, hearing loss, jaw pain) and signs (e.g., tenderness of the tragus or pinna) indicating inflammation of the ear canal. Because there is a variance in management options and because accurate diagnosis of AOE is important, the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) chose to update its previously released guideline on AOE.

Acute otitis externa (AOE) is a common complaint seen in pediatric as well as adult emergency departments. AOE is typically not accompanied by acute otitis media, although concurrent cases are possible. Also called swimmers ear due to the increased likelihood of developing after prolonged submersion in water, AOE can be caused by trauma, foreign bodies (e.g., q-tips), ear piercing, or exposure to high humidity or temperature.. Patients will present with otalgia, itching, swelling, redness, and possibly hearing loss. Bacterial causes are by far the most common in acute otitis externa, although consider fungal etiologies particularly in chronic cases (over 3 weeks), as this will change management. For mild to moderate cases, topical antibiotics with coverage for Pseudomonas are usually sufficient; consider systemic antibiotics for severe cases.. In severe cases, or if the canal looks very swollen, another trick is to place an ear wick (or otowick); unbeknownst to me, we carry these in intake. ...

Commonly known as swimmers ear, otitis externa is one of the conditions that Ciprodex is used to treat. This eMedTV page covers symptoms of this condition and also provides some helpful prevention tips to keep you from getting it in the first place.

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SAN DIEGO, July 28, 2015-- Otonomy, Inc., a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapeutics for diseases and disorders of the ear, today announced the enrollment of the first patients in a Phase 2 clinical trial evaluating AuriPro TM for the treatment of patients with acute otitis externa,...

As spring spreads across the country, the change in temperature and slanting of the sun promises that summer is soon on its heels. For many primary care physicians and otolaryngologists, particularly those living in northern climes, that means an upsurge in people presenting with acute otitis externa, a condition that is estimated to afflict from 1 in 100 to 1 in 250 persons in the general population.. ...

In another post, I discussed ketamine (Ketalar), which some people are hailing as a miracle drug for depression.. Often referred to as Special K, it has been around since the 1960s and is a staple anesthetic in emergency rooms. Ketamine is also an illicit, psychedelic club drug.. In the last 10 years, studies have shown that it can reverse the kind of severe suicidal depression that traditional antidepressants cant treat - and sometimes in the matter of a few hours.. Ketamine isnt quite ready for prime time yet because of concerns about safety and long-term effects. One study published in January 2014 in the British Journal of Clinical Pharmacology included among possible side effects psychedelic symptoms (hallucinations and panic attacks), nausea, cardiovascular stimulation, memory defects, and bladder and renal complications.. But given its tremendous success (75 percent) in treating patients who have been resistant to other depression medications, new ketamine-related treatments are ...

In another post, I discussed ketamine (Ketalar), which some people are hailing as a miracle drug for depression.. Often referred to as Special K, it has been around since the 1960s and is a staple anesthetic in emergency rooms. Ketamine is also an illicit, psychedelic club drug.. In the last 10 years, studies have shown that it can reverse the kind of severe suicidal depression that traditional antidepressants cant treat - and sometimes in the matter of a few hours.. Ketamine isnt quite ready for prime time yet because of concerns about safety and long-term effects. One study published in January 2014 in the British Journal of Clinical Pharmacology included among possible side effects psychedelic symptoms (hallucinations and panic attacks), nausea, cardiovascular stimulation, memory defects, and bladder and renal complications.. But given its tremendous success (75 percent) in treating patients who have been resistant to other depression medications, new ketamine-related treatments are ...

It is generally considered safe for pregnant women to use ketamine (Ketalar). This eMedTV Web selection takes a closer look at the research that has been done on using ketamine during pregnancy, including a list of potential problems that might occur.

Acute otitis externa (AOE) is defined as diffuse inflammation of the external ear canal, which may also involve the pinna or tympanic membrane. [1] Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24. http://oto.sagepub.com/content/150/1_suppl/S1.long http://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com It is a form of cellulitis that involves the skin and subdermis of the external auditory canal, with acute inflammation and variable edema. [1] Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24. http://oto.sagepub.com/content/150/1_suppl/S1.long http://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com It is most commonly caused by bacterial ...

Increasing evidence suggests that P. damselae subsp. damselae outbreaks in fish farms are caused by multiclonal and preexisting natural populations that take advantage of host and environmental conditions in order to cause disease. This hypothesis is reinforced by the observation that virulent isolates are capable of survival for long periods of time in seawater microcosms at 14 to 22°C as culturable bacteria that maintain their infectivity for fish (43). Also, it has been observed that P. damselae subsp. damselae can infect new fish hosts through water, and the spread of the disease largely depended on water temperature (44). Water temperature is indeed of special importance. A few consistent reports associated the occurrence of P. damselae subsp. damselae outbreaks with unusual increases in water temperature (2, 27, 45, 46). Such temperature conditions might increase fish susceptibility to infection by P. damselae subsp. damselae genotypes already present in the environment as free-living ...

p,,em,Euphorbia aegyptiaca ,/em,is a herbaceous plant traditionally used in Sudan for treatment of various diseases, and the study of this plant is still limited. The aim of the present study was to screen the phytochemicals and to assess the Antioxidant activity, total phenolic, flavonoid contents and cytotoxic activity of ,em,Euphorbia aegyptiaca,/em,. The plant material was extracted successively by Soxhlet apparatus using n-hexane, chloroform and methanol. The chemical constituents of the extracts were carried out using the standard procedures. The Folin- Ciocalteu and Aluminium chloride method was employed to calculate the total phenolic and flavonoid content, respectively. The antioxidant activity, was assessed by measuring the scavenging activity of the DPPH (2.2Di (4-tert-octylphenyl)-1-picryl-hydrazyl) and Propyl Gallate as standard antioxidants. While cytotoxic activities were screened using brine shrimp. Phytochemical screening studies revealed that flavonoids, tannins, coumarins, ...

The thesis entitled Enantioselective synthesis of didemniserinolipid, cladospolides, aspercyclide and muricatacin is divided into three chapters. First chapter of the thesis deals with the formal total synthesis both enantiomers didemniserinolipid B from L-(+)-tartaric acid. Fused bicyclic acetals containing 6,8-dioxabicyclo[3.2.1]octane structural unit are wide spread in bio active natural products. Didemniserinolipids A-C possessing similar framework were isolated from a methanol extract of Didemnum sp., and some of the analogous compounds were found to be cytotoxic against P388, A549, and HT29 tumor cell lines. Pivotal reactions en route to the natural product include the elaboration of a γ-hydroxy amide derived from tartaric acid, olefin cross metathesis and Wittig olefination (Scheme 1). (+)-didemniserinolipid B Scheme 1: Retrosynthesis of both enantiomers of didemniserinolipid B. Second chapter of the thesis describes an enantiodivergent synthesis of macrolactones: In section A, ...

SAN DIEGO, Dec. 1, 2015 (GLOBE NEWSWIRE) - Otonomy, Inc. (Nasdaq:OTIC), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapeutics for diseases and disorders of the ear, today announced it has completed enrollment in a Phase 2 trial of OTIPRIOTM in patients with acute otitis externa, also known as swimmers ear, and that preliminary results demonstrate clinical feasibility of OTIPRIO for this label expansion indication.The one-month, prospective, multicenter, open label Phase 2 clinical trial enrolled a total of 75 pediatric and adult patients with unilateral acute otitis externa. Patients were randomized to receive a single administration of OTIPRIO at one of three dose volumes: 0.1 mL, 0.2 mL and 0.4 mL. Results of this trial demonstrate the feasibility of administering OTIPRIO, a thermosensitive gel containing ciprofloxacin, into the external ear canal of awake patients by a physician in the office setting. In addition, preliminary ...

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Pereira, Leila M. M. B.; Martelli, Celina M. T.; Merchán-Hamann, Edgar; Montarroyos, Ulisses R.; Braga, Maria C.; Lima, Maria L. C. de; Cardoso, Maria R. A.; Turchi, Marília D.; Costa, Marcelo A.; Alencar, Luiz C. A. de; Moreira, Regina C.; Figueiredo, Gerusa M.; Ximenes, Ricardo A. A. ...

Oncotarget | https://doi.org/10.18632/oncotarget.7456 Gabrielis Kundrotas, Evelina Gasperskaja, Grazina Slapsyte, Zivile Gudleviciene, Jan Krasko, Ausra Stumbryte, Regina Liudkeviciene

Photobacterium damselae subsp. damselae (formerly Vibrio damsela) is a pathogen of a variety of marine animals including fish, crustaceans, molluscs, and cetaceans. In humans, it can cause opportunistic infections that may evolve into necrotizing fasciitis with fatal outcome. Although the genetic basis of virulence in this bacterium is not completely elucidated, recent findings demonstrate that the phospholipase-D Dly (damselysin) and the pore-forming toxins HlyApl and HlyAch play a main role in virulence for homeotherms and poikilotherms. The acquisition of the virulence plasmid pPHDD1 that encodes Dly and HlyApl has likely constituted a main driving force in the evolution of a highly hemolytic lineage within the subspecies. Interestingly, strains that naturally lack pPHDD1 show a strong pathogenic potential for a variety of fish species, indicating the existence of yet uncharacterized virulence factors. Future and deep analysis of the complete genome sequence of Photobacterium damselae subsp. damselae

Chicory (Cichorium intybus L.) is a traditional European crop that is highly appreciated for its contents of bioactive compounds, especially phenolics, which have high antioxidant activities. Among other factors, agricultural practice might affect the contents of these bioactive compounds, which are also important from a nutritional point of view, and affect the shelf-life. The antioxidant potential (AOP) of chicory plants treated with different fertilisers was investigated in vitro using DPPH radical scavenging and in vivo using the yeast Saccharomyces cerevisiae. Additionally, total phenolics content (TPC) was evaluated using Folin-Ciocalteu reagent, and total flavonoids content (TFC) using the aluminium chloride method. Four different chicory cultivars were included: Treviso, Verona and Anivip as red cultivars; and Castelfranco as a red-spotted cultivar. These were grown in pots under controlled glasshouse conditions using organic and/or mineral fertilisers. The combination of organic and

Clausena excavata (Lour.), locally known as Kemantu hitam, is a common plant in Malaysian folklore medicine. This study evaluated the antioxidant properties of the solvent extracts of C. excavata leaves and determined the acute toxicity of methanolic extract C. excavata (MECE) leaves in Sprague-Dawley rats. Harvested leaves were dried and subjected to solvent extraction using petroleum ether, chloroform, ethyl acetate and methanol in succession. The antioxidant activity of each extract was determined using the ferric-reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picryl dihydrazyl (DPPH) radical scavenging activity. The total phenolic content (TPC) and total flavonoids content (TFC) were estimated by Folin-Ciocalteu and ethanolic aluminium chloride method, respectively. The chloroform extract was found to be highest in flavonoid content, while the methanolic extract showed the highest TPC and antioxidant activity. There was no mortality in rats treated with MECE leaves even at a high ...

Cellulitis of the Face, Malignant Otitis Externa, Thick Facial Skin Symptom Checker: Possible causes include Otitis Externa, Acute Otitis Externa, Chronic Otitis Externa. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

The ear of a person suffering from acute otitis externa; inflammation of the outer ear (pinna) and the canal leading down to the eardrum (external auditory meatus). Otitis externa can be caused by both fungal and bacterial infections and is more common in swimmers (swimmers ear) and those with eczma and diabetes. Symptoms include itching, pain, a slight discharge and temporary deafness. - Stock Image M157/0023

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The government of Saskatchewan is recommending people avoid all unnecessary travel to and from Regina. The direction comes as coronavirus variant transmission continues to increase in the Queen City. As of March 22, there were 156 confirmed variants of concern cases in the province, with 90 per cent - 141 cases - in Regina. There are also 748 presumptive variants of concern cases in Saskatchewan and 640 of those are in Regina. The province said people in Regina should not increase their household bubbles and should stay with their current household. Worship services around Saskatchewan have expanded, however they are not permitted to do that in Regina until April 5. The province said the request to avoid unnecessary travel is one of the ways to minimize the risk in the city and throughout the region. Other ways are for people to reduce activities outside of their home, order take-out or curbside pick-up and work from home if possible.

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Regina Holliday is a resident of Grantsville, Maryland. She serves on the board of the local non-profit The Highland Thrift Shop. She is a member of the Grantsville Rotary Club. She is also Asst. Cubmaster of Pack 460 Cub Scouts. In addition, Regina serves as a parent advisor to the Garrett County School Board Health Advisory Committee. She is also a member of the Garrett County Chamber of Commerce and The Garrett County Arts Council. That being said, her good works do not stop at the county line. Some people call her the Rosa Parks of Health Care.. Ms. Holliday is an activist, artist, speaker and author. You might see her at a health conference painting the content she hears from the patient view. She is part the movement known as participatory medicine. She and others in this movement believe that the patient is a partner with their provider and both should work together as a team. Regina is a mother and a widow; she speaks about the benefits of health information technology and timely data ...

Regina Holliday is a resident of Grantsville, Maryland. She serves on the board of the local non-profit The Highland Thrift Shop. She is a member of the Grantsville Rotary Club. She is also Asst. Cubmaster of Pack 460 Cub Scouts. In addition, Regina serves as a parent advisor to the Garrett County School Board Health Advisory Committee. She is also a member of the Garrett County Chamber of Commerce and The Garrett County Arts Council. That being said, her good works do not stop at the county line. Some people call her the Rosa Parks of Health Care.. Ms. Holliday is an activist, artist, speaker and author. You might see her at a health conference painting the content she hears from the patient view. She is part the movement known as participatory medicine. She and others in this movement believe that the patient is a partner with their provider and both should work together as a team. Regina is a mother and a widow; she speaks about the benefits of health information technology and timely data ...

Regina Holliday is a resident of Grantsville, Maryland. She serves on the board of the local non-profit The Highland Thrift Shop. She is a member of the Grantsville Rotary Club. She is also Asst. Cubmaster of Pack 460 Cub Scouts. In addition, Regina serves as a parent advisor to the Garrett County School Board Health Advisory Committee. She is also a member of the Garrett County Chamber of Commerce and The Garrett County Arts Council. That being said, her good works do not stop at the county line. Some people call her the Rosa Parks of Health Care.. Ms. Holliday is an activist, artist, speaker and author. You might see her at a health conference painting the content she hears from the patient view. She is part the movement known as participatory medicine. She and others in this movement believe that the patient is a partner with their provider and both should work together as a team. Regina is a mother and a widow; she speaks about the benefits of health information technology and timely data ...

Regina Holliday is a resident of Grantsville, Maryland. She serves on the board of the local non-profit The Highland Thrift Shop. She is a member of the Grantsville Rotary Club. She is also Asst. Cubmaster of Pack 460 Cub Scouts. In addition, Regina serves as a parent advisor to the Garrett County School Board Health Advisory Committee. She is also a member of the Garrett County Chamber of Commerce and The Garrett County Arts Council. That being said, her good works do not stop at the county line. Some people call her the Rosa Parks of Health Care.. Ms. Holliday is an activist, artist, speaker and author. You might see her at a health conference painting the content she hears from the patient view. She is part the movement known as participatory medicine. She and others in this movement believe that the patient is a partner with their provider and both should work together as a team. Regina is a mother and a widow; she speaks about the benefits of health information technology and timely data ...

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Regina tomato, a locally cultivated Italian landrace, is listed as an item in the ‘List of Traditional Agri-Food Products’ of the Italian Department for Agriculture and itemised as ‘Slow Food presidium’ by the Slow Food Foundation. It is classified as a long-storage tomato since it can be preserved for several months after harvest thanks to its thick and coriaceous skin. Three ecotypes were investigated for main physical and chemical traits both at harvest and after three months of storage. Experimental results indicate that this tomato landrace has a qualitative profile characterized by high concentrations of tocopherols, lycopene and ascorbic acid (maximum 28.6 and 53.7 mg/kg fresh weight, FW, and 0.28 mg/g FW, respectively) even after a long storage time, together with lower average Total Soluble Solids. The initial and post-storage contents of the bioactive compounds changed at a different rate in each ecotype (i.e., in Monopoli Regina tomato the highest content of α

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Media Advisory Release Date: September 3, 2015 12:00 p.m. There is plenty to see and do at the University of Regina as new and returning students prepare for the Fall 2015 semester. Student orientation events help facilitate the transition from high school to University, and introduce incoming students to the University, including available student programming and supports ...

Starring Regina King is a comprehensive website dedicated to actress Regina King, containing a large picture gallery, multimedia, news and more.

Regina Pereira trocou de clube no Minho. A internacional portuguesa, que se tinha desvinculado recentemente do SC Braga, foi esta segunda-feira apresentada como reforço do FC Famalicão. A médio defensivo de 28 anos vai, assim, representar o seu quinto clube da carreira, depois de passagens pelo ARC Sequeade, Vilaverdense FC, Valadares Gaia e SC Braga. Ao serviço do SC Braga nas últimas quatro temporadas, Regina venceu três títulos - um campeonato, uma Taça de Portugal e uma Supertaça. ...

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Bodacious Blinds of Regina provides window coverings and treatments for clients throughout Saskatchewan. If you are looking for a professional window treatment company call Bodacious Blinds.

Dr. Gregory is Founding Dean, Faculty of Nursing, University of Regina. Dr. Gregory received the title of Dean Emeritus from the University of Manitoba in June 2011. Prior to his arrival on April 1, 2011, Dr. Sheila Dresen served as Acting Dean and ensured a solid foundation upon which to develop the Faculty of Nursing. Dr. Gregory comes to the University of Regina from the University of Lethbridge. david has two Jack Russells, Daisy and Dingo. He is an avid reader of Canadian fiction and enjoys gardening.. ...

Paromomycin Sulfate (Paromomycin Sulfate) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.

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For disclaimers, see Part 1. Part 11. Chapter Eleven. Sometime during the night, they managed to cover their naked bodies with the down comforter from Regina s bed. Cuddling together, the two women made love again, slowly, and with a tenderness born of their newfound intimacy. They awoke, limbs tangled together just before daybreak, with the bed covers in complete disarray around them. Alex stretched and wriggled her feet before she curled herself around the smaller body snuggled up against her side. She sighed contentedly, feeling free from her worries about Regina and their relationship for the first time in weeks. Regina stirred beside her, lifted her head from beneath the nest of blankets, and blinked. Mm, morning. She smiled sheepishly, feeling bruised and swollen from their long night of lovemaking. Once they crossed that particular bridge, their bodies seemed insatiable.. Alex kissed the tip of Regina s nose and smiled down at her. How do you feel? She playfully ruffled the tousled ...

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Click the link below to download the RCAs 2020 Covid-19-Pandemic package:. 1_REGINA CONSTRUCTION ASSOCIATION_Pandemic_P5-29-2 (updated 5/29/2020). Please email any questions or concerns to Darlene at [email protected] and Kevin at [email protected]. ...

Adecco is currently hiring a permanent, full-time Operations Manager - Warehouse to work in Regina, SK. The Warehouse Manager will be responsible in o

Helsinki band Regina bring a glossy synthed out world of dreamy pop expression on their upcoming album, Soita Mulle, out Tuesday on Friendly Fire Recordings. I

Regina Dahlhaus is the author of this article in the Journal of Visualized Experiments: Studeren Eiwit functie en de rol van veranderde eiwitexpressie door Antibody Interferentie en driedimensionale Reconstructies

Lyrics to Two Birds by Regina Spektor: Two birds on a wire / One tries to fly away / And the other watches him close from that wire / He

The Southey Primary Health Care Centre walk in clinic is located in Regina, SK. View their contact details, location, list of services and schedules.

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Ester 7:3 Allora la regina Ester rispose, e disse: Se io ho trovata grazia appo te, o re, e se così piace al re, siami donata la mia vita alla mia richie... Read chapter in Giovanni Diodati 1649 (Italian)

Here is the best resource for homework help with CHEM& 104 at University Of Regina. Find CHEM&104 study guides, notes, and practice tests from University of

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A - take the train to Termini railway station, the train makes no intermediate stops, it takes about 30 minutes and the ticket cost is around 14 €. From Termini station take the underground B line direction Rebibbia and go down to Policlinico stop, from Policlinico stop walk along Viale Regina Elena and turn right to Viale Ippocrate. The hotel is on your right after the first cross.. B - take the train to Tiburtina railway station, the train makes some intermediate stops, it takes about 45 minutes and the ticket cost 8 €. From Tiburtina station then take the underground B line direction Laurentina, go down to Policlinico stop, from Policlinico stop walk along Viale Regina Elena and turn right to Viale Ippocrate. The hotel is on your right after the first cross.. From Termini railway station: take the underground B line direction Rebibbia up to Policlinico stop, from Policlinico stop walk along Viale Regina Elena and turn right to Viale Ippocrate. The hotel is on ...

Nu este recomandat sa-ti faci testul Papanicolau cand esti la menstruatie. Testul identifica daca sunt modificari precanceroase la nivelul celulelor colului uterin.