Multiple myeloma is a malignant plasma cell disorder diagnosed annually in approximately 86,000 participants worldwide. JNJ-68284528 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy that targets B-cell maturation antigen (BCMA), a molecule expressed on the surface of mature B lymphocytes and malignant plasma cells. The primary hypothesis for this study is that JNJ-68284528 will significantly improve progression free survival (PFS) compared with standard therapy (PVd or DPd), in participants who have previously received 1 to 3 prior line(s) of therapy, that included a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD) and who are refractory to lenalidomide. This study will be conducted in 3 phases: Screening (up to 28 days before randomization), Treatment, and Follow-Up. Assessment like patient-reported outcome(s) (PROs) assessments, electrocardiogram (ECG), vital signs, pharmacokinetic will be performed during the study. Safety evaluations will include review of ...

Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a dual epitope-binding CAR T cell therapy directed against 2 distinct B cell maturation antigen epitopes, in patients with relapsed/refractory (R/R) multiple myeloma (MM). This ongoing phase 1, single-arm, open-label, multicenter study enrolled patients (18 to 80 years) with R/R MM. Lymphodepletion was performed using cyclophosphamide 300 mg/m2. LCAR-B38M CAR T cells (median CAR+ T cells, 0.5 × 106 cells/kg [range, 0.07 to 2.1 × 106]) were infused in 3 separate infusions. The primary objective is to evaluate the safety of LCAR-B38M CAR T cells; the secondary objective is to evaluate the antimyeloma response of the treatment based on the general guidelines of the International Myeloma Working Group. At data cutoff, 57 patients had received LCAR-B38M CAR T cells. All patients experienced ≥ 1 adverse events (AEs). Grade ≥ 3 AEs were reported

Managing Myeloma is an educational initiative dedicated to developing tools, information, and resources that support improved therapeutic outcomes for patients diagnosed with multiple myeloma.

The purpose of this pilot study is to test the safety and efficacy of giving targeting CD138 or B-cell maturation antigen T cells in treating patients with

Photo: Pixabay prnewswire.com The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed CAR-T therapy, demonstrated sustained efficacy and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM). Updated results from the Phase 1b/2 CARTITUDE-1 study (n=97) with a longer-term follow-up at a median of 18 months showed an overall response rate (ORR) of 98 percent, with 80 percent of patients achieving a stringent complete response (sCR), highlighting a deepening response over time (increasing from 67 percent presented at ASH 2020).1 These data also showed 66 percent of patients were progression free and alive at 18 months (95 percent Confidence Interval [CI], range, 54.9–75.0). The latest findings to be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, showed an overall survival

ADC molecules are engineered to deliver potent cytotoxic compounds to specific antigen-expressing target cells.1,2 Antigen binding domains recognize specific surface proteins, such as B-cell maturation antigen (BCMA), which allows for targeting of cells expressing BCMA, such as plasma and multiple myeloma cells .1,2 ADCs built with non-natural amino acid linkers could potentially ensure that the cytotoxic payload reaches the target cell.1,3 Cytotoxic molecules induce cell death when internalized by antigen-expressing target cells.3 Preclinical studies have shown that ADCs can attack tumors directly, independent of the immune system.4 Preclinical studies are ongoing to optimize, improve, and assess the potential benefits and risks of ADCs as single agent therapy or in combination with other therapies.3,5. ...

The use of monoclonal antibodies (mab) can in some cases interfere with the follow-up of MM during the assay protein electrophoresis. The thesis presents some new methods for differentiating the two immunoglobulins making correct follow-up of the disease possible. Other methods presented are new biomarkers such as B-cell maturation antigen (BCMA) and the ratio between the monocyte count and lymphocyte count, a ratio you get from the complete blood count. BCMA seems to be a promising biomarker but more research is needed before conclusions can be made about the leukocyte ratios as biomarkers because different results have been reported in articles ...

During this years annual meeting, Seattle Genetics and Unum Therapeutics presented pre-clinical data evaluating combination treatment with Antibody-Coupled T cell Receptor (ACTR) engineered autologous T cells and an antibody targeting B-cell maturation antigen or BCMA.. The ACTR technology enables the programming of a patients immune system to attack tumor cells when co-administered with tumor-specific therapeutic antibodies. The pre-clinical data support clinical evaluation of a humanized non-fucosylated anti-BCMA antibody, known as SEA-BCMA, being developed using Seattle Genetics novel sugar-engineered antibody (SEA) technology, and ACTR T cell combination treatment in multiple myeloma patients.. Designed to engage the Fc domain of therapeutic antibodies, the ACTR technology, is a universal, engineered T cell therapy consisting of the extracellular domain of human CD16 and the intracellular T cell co-stimulatory and signal domain.. One presentation highlighted data from pre-clincal studies ...

Acronyms and Abbreviations: ALL, acute lymphatic leukemia; BCMA, B-cell maturation antigen; CAR, chimeric antigen receptor; cDNA, complementary DNA; CDR3, complementarity determining region 3; CEA, carcinoembryonic antigen; CLL, chronic lymphatic leukemia; CMV, cytomegalovirus; CRS, cytokine release syndrome; CTL, cytotoxic T lymphocyte; DLI, donor lymphocyte infusion; E, early viral protein; EBV, Epstein-Barr virus; EGFR, epidermal growth factor receptor; ERBB2IP, erbb2 interacting protein; GD2, disialoganglioside; GVHD, graft-versus-host disease; GVL, graft-versus-leukemia; HHV-6, human herpes virus-6; HLA, human leukocyte antigen; HSCT, hematopoietic stem cell transplantation; HSV, herpes simplex virus; HSV-TK, herpes simplex virus thymidine kinase; iCasp9, inducible caspase-9; IE, immediate early viral protein; IFN-γ, interferon-γ; IL, interleukin; L1CAM, L1-cell adhesion molecule; LCL, lymphoblastoid cell line; LPD, lymphoproliferative disease; mAbs, monoclonal antibodies; mHAgs, minor ...

Monoclonal and Bispecific Anti-BCMA Antibodies in A number of Myeloma B-cell maturation antigen (BCMA), a member of the tumor […]. Read more → ...

Update-1 BLUE Drops 1.96% and 1.77% After Hours 6/3 In the bubbly CAR-T world bluebird bio (BLUE) and Celgene announced a deal for for development of product candidates for B-cell maturation antigen (BMCA) utilizing bluebird bioss gene therapy technology to modify a patients own T-Cells to target cancer cells. A $25M up-front payment was made but […]. ...

BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM. Twenty-five subjects were treated in 3 cohorts as follows: cohort 1, 1 × 108 to 5 × 108 CART-BCMA cells alone; cohort 2, cyclophosphamide (Cy) 1.5 g/m2 plus 1 × 107 to 5 × 107 CART-BCMA cells; cohort 3, Cy 1.5 g/m2 plus 1 × 108 to 5 × 108 CART-BCMA cells. No prespecified BCMA expression level was required. RESULTS. CART-BCMA cells were manufactured and expanded in all subjects. Toxicities included cytokine release syndrome and neurotoxicity, which were grade 3-4 in 8 (32%) and 3 (12%) subjects, respectively, and reversible. One subject died at day 24 from candidemia and progressive myeloma, following treatment for ...

BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM. Twenty-five subjects were treated in 3 cohorts as follows: cohort 1, 1 × 108 to 5 × 108 CART-BCMA cells alone; cohort 2, cyclophosphamide (Cy) 1.5 g/m2 plus 1 × 107 to 5 × 107 CART-BCMA cells; cohort 3, Cy 1.5 g/m2 plus 1 × 108 to 5 × 108 CART-BCMA cells. No prespecified BCMA expression level was required. RESULTS. CART-BCMA cells were manufactured and expanded in all subjects. Toxicities included cytokine release syndrome and neurotoxicity, which were grade 3-4 in 8 (32%) and 3 (12%) subjects, respectively, and reversible. One subject died at day 24 from candidemia and progressive myeloma, following treatment for ...

Belantamab mafodotin, also known as GSK2857916, is an investigational anti-TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)], humanized monoclonal antibody conjugated, on an average of 4 cysteinyl, to monomethyl auristatin F (MMAF), via a noncleavable maleimidocaproyl (mc) linker.

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SUMMIT, N.J. & CAMBRIDGE, Mass.-(BUSINESS WIRE)- Celgene Corporation (NASDAQ: CELG) and bluebird bio, Inc. (Nasdaq: BLUE) today announced that updated results from the ongoing CRB-401 Phase 1 clinical study of bb2121, an investigational anti-B-cell maturation antigen (BCMA) CAR T cell therapy, in 21 patients with late-stage relapsed/refractory multiple myeloma will be presented in an oral presentation …. ...

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Buy our Recombinant Mouse BCMA protein. Ab109162 is a protein fragment produced in HEK 293 cells and has been validated in FuncS, SDS-PAGE. Abcam provides free…

A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN ...

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The samples used in this paper were obtained from patients with osteoarthritis (OA) or RA during knee-TEP operations. First of all, expression of the known BAFF-binding receptors BCMA, TACI and BAFF-R was analyzed in SF of patients with OA and RA using flow cytometry and immunohistochemistry. In a further step, the influence of several stimulants, including cytokines, TLR-agonists and cell activators on receptor expression was tested. Finally, taking into account BAFF function in other cell types, SF were stimulated with BAFF and stained with Annexin V in order to analyze its effect on apoptosis in SF ...

EGT1442 BAFF or Apr can induce activation sign in THP-1 cells which react to the excitement via production of the cytokine, IL-8, or a matrix degrading enzyme, MMP-9 (9,10). The siBAFF-transfected cells were EGT1442 tested for the responsiveness to BAFF or APRIL-mediated signaling then. As demonstrated in Fig. 2A, cells transfected with control siRNA taken care of immediately both anti-APRIL and anti-BAFF mAb and expressed large degrees of IL-8. Cells transfected with siBAFF didnt respond to the procedure with anti-BAFF mAb but taken care of immediately anti-APRIL mAb at a rate just like LPS response. The siBAFF-transfected cells had been after that treated with real estate agents that imitate its counterparts such as for example fusion protein including extracellular site of TACI (or BCMA) and Fc MYO5A part of human being immunoglobulin (TACI:Fc or BCMA:Fc). As demonstrated in Fig. 2A, both TACI:Fc and BCMA:Fc activated the cells expressing IL-8 at a rate slightly significantly less than that ...

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अपनी कालगणना का हम सतत स्मरण करते हैं किन्तु हमें ध्यान नहीं रहता है। जब हम किसी नये व्यक्ति से मिलते हैं तो उसे अपना परिचय देते हैं कि अमुक देश, प्रदेश, या गांव के निवासी हैं, अमुक पिता की संतान है। इसी प्रकार जब हम किसी शुभ कार्य का संपन्न करन के लिए किसी देव शक्ति का आवाहन करते हैं तो उसे संकल्प करते समय अपना परिचय बताते हैं। संकल्प के समय पुरोहितगण एक मंत्र बोलते हैं, जिस पर हम विशेष ...

Translation of caries | The most common chronic disease of childhood is early childhood caries (dental caries in children younger than six years

B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. It is produced by macrophages, dendritic cells, and T lymphocytes. BAFF promotes the survival of B cells and is essential for B cell maturation (1‑4). BAFF binds to three TNF receptor superfamily members: B‑cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF-R selectively binds BAFF. Mouse BAFF-R cDNA encodes a 175 amino acid residue (aa) transmembrane protein with a 71 aa extracellular domain, a 21 aa transmembrane domain, and a 83 aa cytoplasmic region. A second isoform of BAFF R that has a 72 aa cytoplamic region can also be ...

Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs contribute to the endothelial dysfunction. Through ex vivo and in vitro studies, we aimed at evaluating the effects of B lymphocyte stimulator (BLyS) on EPC colonies and endothelial cells and also investigating BLyS receptor expression on these cells. EPCs were isolated from peripheral blood mononuclear cells (PBMC). In order to evaluate their ability to form colonies, EPCs were cultured on fibronectin-coated dishes and incubated with BlyS alone or BlyS and belimumab. Apoptosis of EPCs and endothelial cell line EA.hy926 was evaluated after 6, 12, and 24 h of incubation with BLyS and after 6 h with BLyS and belimumab. The expression of B cell activating factor-receptor (BAFF-R), B cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor

A Tumor Necrosis Factor superfamily member that plays a Role in the Regulation of B-Lymphocyte Survival. It occurs as a Membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to Transmembrane Activator and CAML Interactor Protein; B-Cell Activation Factor Receptor; and B-Cell Maturation Antigen ...

CD268 (BAFF Receptor), clone: 8A7, eBioscience™ 25μg; Unconjugated CD268 (BAFF Receptor), clone: 8A7, eBioscience™ Primary Antibodies CD251 to CD400

CD268 (BAFF Receptor), PE, clone: 8A7, eBioscience™ 100 Tests; PE CD268 (BAFF Receptor), PE, clone: 8A7, eBioscience™ Primary Antibodies CD251 to CD400

BAFF receptor (BAFF = B cell-activating factor of the TNF family) is a main pro-survival receptor expressed by human B cells. BAFFR deficiency is caused by a homologous deletion within the BAFFR gene...

Complete information for FAF2 gene (Protein Coding), Fas Associated Factor Family Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

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Background The TNF superfamily member B lymphocyte stimulator (BLyS), referred to as BAFF, is known to be an effective modulator of peripheral B cell homeostasis that promotes B cell survival and differentiation. BLyS is expressed by a few stromal cells, T cells, and most myeloid cell. BLyS transgenic mice show an expansion of the peripheral mature B cell compartment, hyperglobulinemia, anti-single-stranded DNA and anti-double-stranded DNA antibodies, and circulating immune complexes. A proliferation-inducing ligand (APRIL) is a homolog to BLyS that is expressed by monocytes, macrophages, DCs, T cells, and others. APRIL is virtually undetectable in normal tissues but is strongly expressed in adenocarcinomas and can accelerate the growth of malignant cells in vitro and in vivo. APRIL/BLyS heterotrimers are present in the serum of patients with systemic autoimmune diseases like rheumatoid arthritis (RA), SLE, and SS. APRIL over expression promotes a strong survival signal for both CD4+ and CD8+ T ...

Toda la información sobre las últimas publicaciones científicas de la Clínica Universidad de Navarra. Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer

The development and antigen-dependent differentiation of B lymphocytes are orchestrated by an array of growth factors, cytokines, and chemokines that require tight spatiotemporal regulation. Heparan sulfate proteoglycans specifically bind and regulate the bioavailability of soluble protein ligands, but their role in the immune system has remained largely unexplored. Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding. Here we show that Glce deficiency impairs B-cell maturation, resulting in decreased plasma cell numbers and immunoglobulin levels. We demonstrate that C5-epimerase modification of heparan sulfate is critical for binding of a proliferation inducing ligand (APRIL) and that Glce-deficient plasma cells fail to respond to APRIL-mediated survival signals. Our results identify heparan sulfate proteoglycans as novel players in B-cell maturation and differentiation and suggest that heparan sulfate ...

Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.

The monoclonal antibody 11C1 reacts with the B cell-activating factor receptor (BAFF-R), also known as BAFF receptor 3 (BR3) or CD268. It is a 19 kDa type III transmembrane protein which belongs to the TNF receptor superfamily and is mainly expressed on B cells. BAFF-R plays an important role in B cell differentiation and promotes survival and activation of B cells. - Belgique

The principle role of the company is to identify, to verify the validity and ultimately to offer a range of biochemical assays each of which will provide unique and informative results to the condition of an individual patient from which the physician can

There are comments on PubPeer for publication: Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen (2010)

A Proliferation Inducing Ligand (APRIL) is a TNF ligand that, via its receptors TACI and BCMA, is involved in both B cell physiology as well as in proliferation and survival of malignant B cells. To target APRIL-dependent stimulation of B cell cancers, we recently produced and characterized two monoclonal antagonistic anti-human APRIL antibodies called humanAPRIL.01A (hA.01A) and humanAPRIL.03A (hA.03A). In a first biochemical assay to validate their blocking activity, hA.01A was shown to fully prevent APRIL from binding to its receptors, whereas a substantial difference was detected for hA.03A, which inhibited APRIL binding to BCMA less efficiently than hA.01A. Epitope mapping subsequently revealed that hA.01A and hA.03A bind distinct sites on APRIL, which provided a structural rationale of their different blocking activities. Importantly, this differential inhibition profile can be used to functionally dissect BCMA and TACI-dependent signals and indicated that B cell survival and IgA ...

Είναι το τελευταίο ποίημα του Σεφέρη και δημοσιεύτηκε στο Βήμα (23.9.71) τρεις μέρες μετά το θάνατό του στην περίοδο της δικτατορίας. Το ποίημα βασίζεται σε μια περικοπή του Πλάτωνα (Πολιτεία 614 κ.ε.) που αναφέρεται στη μεταθανάτια τιμωρία των αδίκων και ιδιαίτερα του Αρδιαίου. Ο Αρδιαίος, τύραννος σε μια πόλη, είχε σκοτώσει τον πατέρα του και τον μεγαλύτερο του αδερφό του. Γι αυτό και η τιμωρία του, καθώς και των άλλων τυράννων, στον άλλο κόσμο στάθηκε φοβερή. Όταν εξέτισαν την καθιερωμένη ποινή που επιβαλλόταν στους αδίκους και ετοιμαζόταν να βγουν στο ...

Tumor Necrosis Factor Ligand Superfamily Member 13: A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.

B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 cell populations. Hence, it is presently unclear if B-1 cells are responsive to BAFF and if BAFF regulates some aspects of B-1 cell function. We show here that BAFF-R and transmembrane activator and CAML interactor (TACI) are the major receptors expressed by B-1 cells. Specifically, we show that BAFF treatment of B-1 cells leads to increased NF-kappaB p100 processing and CD21/CD35 expression. Interestingly, toll-like receptor (TLR) engagement of B-1 cells augmented the surface expression of BAFF receptors and rendered them responsive to BAFF costimulation, as evidenced by their increased proliferation, expression of cell surface activation markers and secretion of the pro-inflammatory

BCMA Antibody Drug Conjugate Active in Patients With Heavily Pretreated Myeloma - ASH Annual Meeting, Multiple Myeloma, On Location - ASH Clinical News

BAFF大鼠单克隆抗体[Buffy 2](ab16081)可与小鼠, 人样本反应并经WB, IHC, Flow Cyt实验严格验证，被13篇文献引用。所有产品均提供质保服务，中国75%以上现货。

Gentaur molecular products has all kinds of products like :search , Kamiya \ BAFF, FTIC labeled Clone Buffy_2 \ MC-109 for more molecular products just contact us

Помните, как собираясь в Америку, мы задавали друг другу вопрос: А какая у них еда в Америке?! Становясь иммигрантами, мы не хотели расставаться со своими кулинарными традициями. Пакуя чемоданы, мы обязательно ложили в них свои знаменитые кулинарные тетрадки. Всем и каждому было понятно, что это было тем, с чем мы не хотели расставаться. В Америке эти тетрадки будут пополняться новыми рецептами; в эти тетрадки мы будем вносить поправки, чтобы в Новом свете старые рецепты служили нам так же как и много лет тому назад; в эти тетрадки мы будем гордо ...

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Looking for online definition of heat-shock transcription factor family member 5 in the Medical Dictionary? heat-shock transcription factor family member 5 explanation free. What is heat-shock transcription factor family member 5? Meaning of heat-shock transcription factor family member 5 medical term. What does heat-shock transcription factor family member 5 mean?

Results The mean disease duration of SLE was 7,0 [2,0-10,0] years, SLEDAI 2K score - 4 [2-13], SLICC damage index score - 0 [0-1], current prednisone dose - 10,0 [7,5-25,0] mg/day. SLE pts did not differ from healthy controls in BAFF (0,02 [0,02-0,08] vs 0,02 [0,02-0,02] ng/ml) and APRIL (0,01 [0,01-0,62] vs 0,01 [0,01-0,01] ng/ml) levels. Among SLE pts BAFF level correlated with lupus anticoagulant (r=0,88, p,0,05) and ESR (r=0,43, p,0,05); APRIL level correlated with SLEDAI 2K (r=0,55, p,0,01), CRP (r=0,50, p,0,01), antiDNA (r=0,38, p,0,05), creatinine level (r=0,39, p,0,05), current prednisone dose (r=0,55, p,0,01) and CD19 B lymphocytes absolute count (r=0,89, p,0,05). We divided SLE pts on two groups: the 1st- pts with high activity (SLEDAI 2K≥8), the 2nd - pts with low (SLEDAI 2K,8). The patients of 1st group had higher level of APRIL (1,69 [0,01-4,0] vs 0,01 [0,01-0,01] ng/ml, p,0,05) compared to 2nd group and control, there is no difference in BAFF level in these groups.. ...

BAFF and APRIL are innate immune mediators that trigger immunoglobulin G (IgG) and IgA class-switch recombination (CSR) in B cells by engaging the receptor TACI. The mechanism that underlies CSR signaling by TACI remains unknown. Here we found that the cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor that activates transcription factor NF-kappaB signaling pathways via a Toll-interleukin 1 (IL-1) receptor (TIR) domain. TACI lacks a TIR domain, yet triggered CSR via the DNA-editing enzyme AID by activating NF-kappaB through a Toll-like receptor (TLR)-like MyD88-IRAK1-IRAK4-TRAF6-TAK1 pathway. TACI-induced CSR was impaired in mice and humans lacking MyD88 or the kinase IRAK4, which indicates that MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification. ...

Dive into the research topics of Transmembrane activator and CAML interactor (TACI) haploinsufficiency results in B-cell dysfunction in patients with Smith-Magenis syndrome. Together they form a unique fingerprint. ...

Introduction Blisibimod is a potent B cell-activating aspect (BAFF) antagonist that binds to both cell membrane-expressed and soluble BAFF. B cells reverted to baseline, resulting in a calculated 30 percent30 % decrease in total B cells by around 160 days following the 1st dosage. In both solitary- and multiple-dosing SC cohorts, the pharmacokinetic profile indicated sluggish absorption, dose-proportional publicity from 0.3 through 3.0 mg/kg SC and 1 through 6 mg/kg IV, linear pharmacokinetics over the dosage selection of 1.0C6.0 mg/kg, and accumulation ratios which range from 2.21 to 2.76. The comparative increase in memory space B cells had not been associated with security signals, as well as the 1192500-31-4 supplier occurrence of adverse occasions, anti-blisibimod antibodies, and medical laboratory abnormalities had been similar between blisibimod- and placebo-treated topics. Conclusions Blisibimod transformed the constituency from the B cell pool and solitary and multiple dosages of ...

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SED021Mu, FTH1; FTHL6; PIG15; PLIF; Ferritin Heavy Chain; Apoferritin; Placenta Immunoregulatory Factor; Proliferation-Inducing Protein 15; Cell proliferation-inducing gene 15 protein | Products for research use only!

Transducer of ErbB-2, 1 (TOB1) is an antiproliferative factor that belongs the tob/btg1 family. TOB1 and TOB2 have the ability to suppress cell growth in cell culture. TOB1 is phosphorylated by ribosomal S6 serine/threonine kinase. It interacts with ErbB-2 and interferes with growth suppression in B cells. TOB1 also inhibits T cell proliferation and the transcription of some cytokines, including interleukin 2 (IL-2). TOB1 is also known as TROB1, TROB, TOB, APRO6, and proliferation-inducing gene 49 (PIG49).. ...

Transducer of ErbB-2, 1 (TOB1) is an antiproliferative factor that belongs the tob/btg1 family. TOB1 and TOB2 have the ability to suppress cell growth in cell culture. TOB1 is phosphorylated by ribosomal S6 serine/threonine kinase. It interacts with ErbB-2 and interferes with growth suppression in B cells. TOB1 also inhibits T cell proliferation and the transcription of some cytokines, including interleukin 2 (IL-2). TOB1 is also known as TROB1, TROB, TOB, APRO6, and proliferation-inducing gene 49 (PIG49).. ...

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