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TY - JOUR. T1 - Aziridinylbenzoquinone (AZQ) in the treatment of recurrent pediatric brain and other malignant solid tumors - A Pediatric Oncology Group phase II study. AU - Castleberry, R. P.. AU - Ragab, A. H.. AU - Steuber, C. P.. AU - Kamen, B.. AU - Toledano, S.. AU - Starling, K.. AU - Norris, D.. AU - Burger, P.. AU - Krischer, J. P.. PY - 1990/11. Y1 - 1990/11. N2 - To assess the response rates and toxicity of AZQ in children with recurrent brain and other malignant solid tumors, a phase II study was implemented by the Pediatric Oncology Group. Eligible patients received AZQ 18 mg/M2/week i.v. for 4 doses followed by a 2 week rest period. Each dose was given over four hours (1/3 over the initial 20 minutes). After the first year, the dosage was reduced to 13 mg/M2 due to myelotoxicity resulting in treatment delays. No objective responses were observed in 73 evaluable children with various noncentral nervous system tumors. Of the 91 patients with brain tumors, there were 4 CRs and 2 PRs ...
Learn more about 1-methyl-5-trifluoromethyl-1h-benzimidazol-2-amine-hydrobromide. We enable science by offering product choice, services, process excellence and our people make it happen.
5-Trifluoromethyl-1H-indole-2-carboxylic acid 496946-78-2 Precursor and Downstream products, 5-Trifluoromethyl-1H-indole-2-carboxylic acid Precursor products, 5-Trifluoromethyl-1H-indole-2-carboxylic acid Downstream products ect.
A List with 0 English Anagrams of AZIRINES -- -- WordMine.info is a search engine for finding words. The searches can be done in a lots of different languages. Search Type: Crossword Solver, Words that starts with, Words Ending in, Words with, Palindrome Words Matching, Anagrams of, Words From Letters, Words In the Word, Words Matching Pattern,
The development and implementation of a scalable process for the manufacture of the Toll-like receptor (TLR7) agonist PF-4171455 (1) is described. Initial routes used to synthesise 1 in milligram quantities were unsuitable for large-scale synthesis to provide bulk material. As part of the transfer between Medicinal Chemistry and Research-API, collaboration provided a fit for purpose route for the kilo-scale synthesis of 1. Key aspects of the synthesis included (i) a safe and practical synthesis of a key nitropyridone intermediate 7 over four steps, (ii) a sequential regioselective chlorination to selectively functionalise 7 and (iii) use of a carbamate as a tethered carbonyl group, allowing an efficient regiospecific synthesis of 1.. ...
An enantioselective aza-Friedel-Crafts alkylation reaction of indoles with 1-trifluoromethyl-3,4-dihydro-β-carbolines catalyzed by a chiral spirocyclic phosphoric acid has been realized. This methodology provides a facile route to 1-trifluoromethyl-1-indole-substituted tetrahydro-β-carbolines featuring a CF3 Organic Chemistry Frontiers HOT articles for 2017
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
PubMed journal article Preparation of a poly(ethyleneimine) embedded phenyl stationary phase for mixed-mode liquid chromatograph were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Human serum albumin (HSA) is a transport protein very abundant in blood and plasma; one of their main functions is to carry endogenous and exogenous agents in the bloodstream.1 Binding of ligands to HSA is a process that can modulate a number of properties of the carried agent. In this work, the photophysical behaviour of 4-trifluoromethyl-1-hydroxy-naphthalene (TFN) 2, 3, 4 encapsulated within HSA is described. Supramolecular binding of TFN to HSA can be followed by the enhancement of the fluorescence emission after addition of increasing amounts of protein (Figure 1A). A complex [email protected] is detected in the absorption spectrum with maxima at ca. 340 nm ...
This page contains information on the chemical 1-Piperazineethanol, 4-(4-fluoro-3-(trifluoromethyl)phenyl)-alpha-((4-(4-fluoro-3- (trifluoromethyl)phenyl)-1-piperazinyl)methyl)-, phosphate, hydrate (1:2:1) (salt) including: 2 synonyms/identifiers.
Find quality suppliers and manufacturers of 401590-41-8(6-Chloro-3-(trifluoroMethyl)picolinonitrile) for price inquiry. where to buy 401590-41-8(6-Chloro-3-(trifluoroMethyl)picolinonitrile).Also offer free database of 401590-41-8(6-Chloro-3-(trifluoroMethyl)picolinonitrile) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
chemBlink provides information about CAS # 1065103-97-0, 4-Methoxy-2-(trifluoromethyl)pyridine, 4-(Methyloxy)-2-(trifluoromethyl)pyridine, molecular formula: C7H6F3NO.
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of [2R-[2α(S*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)- Morpholine,
Page contains details about tris(3,5-bis(trifluoromethyl)benzoato)bismuth(III) film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Benzeneacetic acid, 4-methoxy-3-(trifluoromethyl)-. CAS 1000566-45-9. MDL Number:MFCD09832302. Molecular Formula:C10H9F3O3. Molecular Weight:C10H9F3O3.
2-Pyridineacetic acid, 4-(trifluoromethyl)-. CAS 1000515-78-5. MDL Number:MFCD09924926. Molecular Formula:C8H6F3NO2. Molecular Weight:C8H6F3NO2.
Looking for TCI AMERICAS 3-(Trifluoromethyl)Benzenethiol,25g (20DF12)? Graingers got your back. Price:$410.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
While the transport of cell surface proteins is relatively easily studied, visualizing the trafficking of intracellular proteins is...
李位仁(2010/08/01-2012/07/31)。重點一子題2---含嘧啶或亞碳配子或C4對稱氧釩中心四聚體之鎳和銅錯合物進行不對稱共軛加成及碳氫化合物氧合化反應之研究。國科會。(NSC 98-2119-M-003-002-MY3 )。主持人 ...
TY - JOUR. T1 - Ethylcholine mustard aziridinium blocks the axoplasmic transport of acetylcholinesterase in cholinergic nerve fibres of the rat. AU - Kása, P.. AU - Hanin, I.. PY - 1985/7. Y1 - 1985/7. N2 - A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks the intraaxonal transport of acetylcholinesterase in the rat. Impairment of the transport of this enzyme in the septo-hippocampal cholinergic fibres and in the sciatic nerve has been studied, using different doses of AF64A. It is demonstrated that the effect on the axonal transport is dose-dependent, but is not related to the mode of drug application. AF64A thus may exert its neurotoxic effects on cholinergic neurons at several target sites of action. In addition to the localized presynaptic mechanisms, it may also be compromising cholinergic function by inhibiting axonal transport in vivo.. AB - A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks ...
1. Concise synthesis of enantiopure alfa-trifluoromethyl alanines, diamines and amino alcohols via the Strecker-type reaction, Huguenot, F. ; Brigaud, T. J. Org. Chem. 2006, 71, 7075-7078. 2. Straightforward synthesis of (S)- and (R)-alfa-trifluoromethyl proline from chiral oxazolidines derived from ethyl trifluoropyruvate, Chaume, G., Van Severen, M.-C., Marinkovic, S. ; Brigaud, T. Org. Lett. 2006, 8, 6123-6126. 3. Convenient asymmetric synthesis of beta-trifluoromethyl-beta-amino acid, beta-amino ketones and gama-amino alcohols via Reformatsky and Mannich type reactions from 2-trifluoromethyl-1,3-oxazolidines, Huguenot, F. ; Brigaud, T. J. Org. Chem. 2006, 71, 2159-2162. 4. Chiral 2-trifluoromethyl-4-phenyloxazolidine : A novel highly performing chiral auxiliary for amides alkylation, Tessier, A. ; Pytkowicz, J. ; Brigaud, T. Angew. Chem. Int. Ed. Engl. 2006, 45, 3677-3681. 5. Gram-Scale Preparation of a p-(C-Glucopyranosyl)-L-phenylalanine Derivative by a Negishi Cross-Coupling Reaction, ...
In this contribution we outline polyelectrolyte (PEL) complex (PEC) nanoparticles, prepared by mixing solutions of the low cost PEL components poly(ethyleneimine) (PEI) and poly(acrylic acid) (PAC). It was found, that the size and internal structure of PEI/PAC particles can be regulated by process, media and structural parameters. Especially, mixing order, mixing ratio, PEL concentration, pH and molecular weight, were found to be sensible parameters to regulate the size (diameter) of spherical PEI/PAC nanoparticles, in the range between 80-1,000 nm, in a defined way. Finally, applications of dispersed PEI/PAC particles as additives for the paper making process, as well as for drug delivery, are outlined. PEI/PAC nanoparticles mixed directly on model cellulose film showed a higher adsorption level applying the mixing order 1. PAC 2. PEI compared to 1. PEI 2. PAC. Surface bound PEI/PAC nanoparticles were found to release a model drug compound and to stay immobilized due to the contact with the aqueous
The relative resistance of malignant glioma to chemotherapy makes the identification of new cytotoxic drugs critically important. The use of short-term cultures derived from these tumors to screen drugs at doses that can be attained within human intracranial tumors provides a model system that should be capable of identifying effective drugs suitable for clinical evaluation. The sensitivity of a panel of short-term cultures derived from 22 malignant astrocytoma and four malignant oligodendroglioma was assessed to aziridinylbenzoquinone (AZQ), etoposide and doxorubicin (DOX) using a [(35)S] methione uptake assay. The ID(50) of each culture was compared to the levels of drug which could be achieved in the tumor using standard doses. There was marked heterogeneity between cultures in response to each drug. Whilst there was no evidence that cultures derived from grade III astrocytoma were more sensitive to any of the drugs than cultures derived from grade IV astrocytoma, cultures derived from ...
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The relative pronoun which refers to inanimate things and to animals: The house, which we had seen only from a distance, impressed us even more as we approached. Nce BibMe makes it easy to create citations, build bibliographies and. JOURNAL OF RITUAL STUDIES. Rs pitt.. E Journal of Ritual Studies is an independent, subscriber based, peer review Journal. Owing the Powers of Ten by Charles and Ray Eames, zooming out into the macrocosmos, zooming in into the. Och Wan and Mark Vanderwerf. A ritual "is a sequence of activities involving gestures, words, and objects, performed in a sequestered place, and performed according to set sequence. A REVIEW OF THE LITERATURE ON ETHNICITY, NATIONAL IDENTITY AND RELATED MISSIOLOGICAL STUDIES. Oroso, Jon William (2014) Reactive Probes for Manipulating Polyketide Synthases, and Photoreactive Probes for Strained Alkyne Click Chemistry techno manager interview essays sketch of the information omniverse Kas Oosterhuis 2017. Using other peoples research or ideas ...
The mechanism of the antiviral activity of 5-trifluoromethyl-2-deoxyuridine (F3TdR) has been studied in vaccinia virus-infected HeLa cells. When normal virions are used to infect the cells in the presence of the analogue, sucrose gradient sedimentation has shown that the early messenger RNA is normal and associates normally with polyribosomes. However, any late mRNA that may be produced under those conditions has abnormal sedimentation properties and does not associate normally with polyribosomes. When the cells are infected with purified virions containing F3TdR in their DNA, they adsorb to the cells and are uncoated normally. However, early mRNA is not transcribed normally. Studies of viral protein synthesis with polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate suggest that a major virus-induced protein is not synthesized in the presence of F3TdR, and that another protein is formed instead.. ...
To get a deeper insight into the function of estrogen-related receptors (ERRs) and dissect underlying mechanism in Leydig cells, ERRs (type α, β and γ) were blocked or activated in testes of adult bank voles (Myodes glareolus) which show seasonal changes in the intratesticular sex hormones level. Both actively reproducing animals (long day conditions; LD) and those with regression of the reproductive system (short day conditions; SD) received intraperitoneal injections of selective ERRα antagonist 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide (XCT 790) or selective ERRβ/ERRγ agonist N-(4-(Diethylaminobenzylidenyl)-N-(4-hydroxybenzoyl)-hydrazine (DY131) (50 μ/kg bw; six doses every other day ...
Еремеев А.В.; Солодин И.В.; Лиепиньш Э.Э.; Костяновский Р.Г. Исследование методов синтеза азиридинов и азиринов на основе этил-beta,beta-бис(трифторметил)акрилата = Investigation of methods for the synthesis of aziridines and azirines on the basis of ethyl-beta,beta-bis(trifluoromethyl) acrilate. Химия гетероцикл.соед. 1984(7), 917-921; Chem.Heterocycl. Comp. (Engl. Ed.). 1984, 20(7), 744-748 ...
2-Iodophenyl acetate 32865-61-5 NMR spectrum, 2-Iodophenyl acetate H-NMR spectral analysis, 2-Iodophenyl acetate C-NMR spectral analysis ect.
Alfa Aesar™ 3-(Trifluoromethyl)phenyltrimethylammonium hydroxide, 5% w/v in methanol 25mL Alfa Aesar™ 3-(Trifluoromethyl)phenyltrimethylammonium...
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Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 180134-15-0(2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid),please inquire us for 180134-15-0(2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid).
1SJI: Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization.
You are viewing an interactive 3D depiction of the molecule 1-(7h-purin-6-yl)-n-[3-(trifluoromethyl)phenyl]-4-piperidinecarboxamide (C18H17F3N6O) from the PQR.
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124444-83-3 - ATTSGZBXNWVPJF-UHFFFAOYSA-N - Piperazine, 1-(3-pyridinylcarbonyl)-4-(2-(trifluoromethyl)phenyl)-, monohydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
1-([4-(Trifluoromethyl)phenyl]carbonyl)piperazine/ACM179334124 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Zhejiang Weihua Chemical Co.,Ltd. is specialized in technology development, chemical manufacturer and trading. Our main products are benzotrifluoride series, total capacity is about 18000mt per year. Including p-chlorobenzotrifluoride is 10000mt annually, 3,4-Dichlorobenzotrifluoride 3000mt annually, etc.
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98-56-6 - QULYNCCPRWKEMF-UHFFFAOYSA-N - 1-Chloro-4-(trifluoromethyl)benzene - Similar structures search, synonyms, formulas, resource links, and other chemical information.
If you would like to contact Kingchem, please call us at +1-201-825-9988. We are in the office between 8:30 to 5:00 (eastern USA time) -- or simply fill out the below short form and we will be in touch with you very soon.. ...
3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID) and [3H]tetracaine, an aromatic amine, are noncompetitive antagonists (NCAs) of theTorpedo species nicotinic acetylcholine receptor (nAChR), which have been shown by photoaffinity labeling to bind to a common site in the ion channel in the closed state. Although tetracaine and TID bind to the same site, the amine NCAs phencyclidine (PCP) and histrionicotoxin (HTX), which are also believed to bind within the ion channel, interact competitively with tetracaine but allosterically with TID. To better characterize drug interactions within the nAChR ion channel in the closed state, we identified the amino acids photoaffinity labeled by [125I]TID in the presence of tetracaine, PCP, or HTX. In the absence of other drugs, [125I]TID reacts with αLeu-251 (αM2-9) and αVal-255 (αM2-13) and the homologous residues in each of the other subunits. None of the NCAs shifted the sites of [125I]TID labeling to other residues within the ion channel. ...
article{1234402, author = {Dhooghe, Matthias and Kenis, Sara and Vervisch, Karel and Lategan, Carmen and Smith, Peter and Chibale, Kelly and De Kimpe, Norbert}, issn = {0223-5234}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, keyword = {Aziridinium salts,Aziridines,Ring opening,Triaminopropanes,Antimalarial agents,INTERMEDIATE AZIRIDINIUM SALTS,PLASMODIUM-FALCIPARUM,PURINE DERIVATIVES,CHIRAL AZIRIDINES,1-ALKYL-2-(BROMOMETHYL)AZIRIDINES,CHEMOTHERAPY,EPOXIDES,POTENT,ASSAY,IONS}, language = {eng}, number = {2}, pages = {579--587}, title = {Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores}, url = {http://dx.doi.org/10.1016/j.ejmech.2010.11.037}, volume = {46}, year = {2011 ...
The mechanism of membrane domain formation was investigated through analysis of domains induced both by calcium and myelin basic protein in vesicles containing components normally enriched in myelin. In the presence of calcium or myelin basic protein, domains enriched in phosphatidic acid, phosphatidylserine, galactocerebroside, and sulfatide were observed to form. In these domains phosphatidic acid or phosphatidylserine co-localized with galactocerebroside and sulfatide. Sphingomyelin was unable to partition into a domain unless sulfatide was also present ...
TY - CHAP. T1 - Tissue distribution and intracerebral tumor penetration of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZO, NSC 182986) in man. AU - Savaraj, Niramol. AU - Lu, K.. AU - Stewart, D.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=17544399898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=17544399898&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:17544399898. VL - Vol. 22. BT - Proceedings of the American Association for Cancer Research. ER - ...
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However, regardless of whether the proposed science fiction background is Rocketpunk or something more like NASA, there is the elephant in the room to consider. Ll text is available to Purdue University faculty, staff, and students on campus through this site. Theses and Dissertations Available from ProQuest. OL 5200 Professional Aspects of Science. Ick on the four letter code to review the undergraduate courses within that discipline.. Oroso, Jon William (2014) Reactive Probes for Manipulating Polyketide Synthases, and Photoreactive Probes for Strained Alkyne Click ChemistryBIOLOGY COURSE DESCRIPTIONS. Search the history of over 284 billion web pages on the Internet. These dissertations are hosted by ProQuest and are free full text access to University of Nebraska Lincoln campus connections and off campus users with UNL IDs! However, regardless of whether the proposed science fiction background is Rocketpunk or something more like NASA, there is the elephant in the room to consider. Submissions ...
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