Auranofin is a thiol-reactive gold (I)-containing compound with potential asa chemotherapeutic. Auranofin has the capacity to selectively inhibit endogenous antioxidant enzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx), resulting in oxidative stress and the initiation of a pro-apoptotic cascade. The effect of Auranofin exposure on TrxR and GPx, and the potential for cellular protection through selenium supplementation was examined in the non-cancerous human cell line Swan-71. Auranofin exposure resulted in a concentration dependent differential inhibition of selenoprotein antioxidants. Significant inhibition of TrxR was observed at 20nM Auranofin with inhibition of GPx from 10µM. Significant increases in reactive oxygen species (ROS) were associated with antioxidant inhibition at Auranofin concentrations of 100nM (TrxR inhibition) and 10µM (TrxR and GPx inhibition), respectively. Evaluation of mitochondrial respiration demonstrated significant reductions in routine and ...
PRIMARY OBJECTIVES:. I. To demonstrate the feasibility of conducting a 10-patient pilot study in asymptomatic ovarian cancer patients with cancer antigen (CA 125) elevation.. SECONDARY OBJECTIVES:. I. To explore whether oral gold therapy either stabilizes or lowers the CA 125 level and maintains patients in an asymptomatic state and to provide descriptive data on tumor response and duration of response.. II. To acquire qualitative data on patients perceptions of learning of CA 125 elevation.. III. To explore whether immunohistochemical staining for PKC iota expression in resected tumor samples appears to be associated with clinical outcomes with auranofin.. OUTLINE:. Patients receive auranofin orally (PO) twice daily (BID) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed up every 6 months for 2 years. ...
High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent.. ...
Professional guide for Auranofin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.. ...
Both amebiasis and giardiasis are currently treated with the antibiotic metronidazole, which has side effects that include nausea, vomiting, dizziness and headache.. The new drug, auranofin, has been used as a twice-daily oral therapy for adults with rheumatoid arthritis since 1985, and has been shown to be safe at that dosage. The researchers laboratory studies indicated that auranofin would be about ten times more potent than the current treatment for dysentery, meaning it could be given at low dose, and on a one-time or limited basis.. "This is a drug that you can find in every country," said Debnath, a postdoctoral fellow at UCSF who led the research and is first author on the paper. "Based on the dosage were seeing in the lab, this treatment could be sold at about $2.50 per dose, or lower. That cost savings could make a big difference to the people who need it the most." International Collaboration. The research stemmed from a joint effort among several labs at UCSF that are affiliated ...
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. ...
Small cell lung cancer (SCLC) is a highly lethal malignancy with the 5-year survival rate of less than 7%. Chemotherapy-resistance is a major challenge for SCLC treatment in clinic. In the study, we...
Through the exceptional capabilities and caring spirit of its people, Vanderbilt will lead in improving the healthcare of individuals and communities regionally, nationally and internationally. We will combine our transformative learning programs and compelling discoveries to provide distinctive personalized care ...
The goals of this TRND project are to develop a treatment for CLL and to develop a novel paradigm for repurposing drugs for rare diseases.
2YAU: A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition.
Purpose:Cancer cells (relative to normal cells) demonstrate increased steady-state levels of hydroperoxides that are compensated for by increased glucose and hydroperoxide metabolism. The current study determined if inhibitors of glucose and hydroperoxide metabolism could induce chemo-radio-sensitization by enhancing oxidative stress in lung cancer cells. Experimental Design:A549 and NCI-H292 human lung carcinoma cells were treated with 2-Deoxy-D-glucose (2DG) combined with carboplatin (carbo) + ionizing radiation (IR). Lung cancer cells were further sensitized with inhibitors of glutathione- and thioredoxin-dependent metabolism [buthionine sulfoximine (BSO) and auranofin (Au), respectively] in vitro and in vivo. Results:When 2DG was combined with carbo+IR, clonogenic cell killing was enhanced in A549 and NCI-H292 cells and this combination was more effective than paclitaxel+carbo+IR. The thiol antioxidant (N-acetylcysteine, NAC) was capable of protecting cancer cells from 2DG+carbo-induced cell ...
Title: Protein Targets for Anticancer Gold Compounds: Mechanistic Inferences. VOLUME: 11 ISSUE: 10. Author(s):Chiara Gabbiani and Luigi Messori. Affiliation:MetMed Lab, Department of Chemistry, University of Florence, via della Lastruccia, 3, 50019 Sesto Fiorentino, Florence, Italy.. Keywords:Gold compounds, cancer, proteins, metal-protein adducts, phosphine complexes, antiproliferative properties, dithiocarbamate complexes, thiosugar ligand, X-ray diffraction, cytochrome c. Abstract: Gold compounds form an interesting class of antiproliferative agents of potential pharmacological use in cancer treatment. Indeed, a number of gold compounds, either gold(III) or gold(I), were recently described and characterised that manifested remarkable cytotoxic properties in vitro against cultured cancer cells; for some of them encouraging in vivo results were also reported toward a few relevant animal models of cancer. The molecular mechanisms through which gold compounds exert their biological effects are ...
In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.
Gold compounds have been employed for the treatment of rheumatoid arthritis (RA) since Forestier pioneered their use for this purpose in 1929. Subsequent randomized trials confirmed the effectiveness of gold in RA (seebelow). Gold has also been used
Shop Thioredoxin/glutathione peroxidase ELISA Kit, Recombinant Protein and Thioredoxin/glutathione peroxidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Cancer stem cells (CSCs) exhibit lower intracellular reactive oxygen species (ROS) levels than non-CSCs, which may be due to the increased expression of free radical scavenging systems. Exogenous agents may be useful to increase ROS and selectively kill CSCs by oxidative stress. Here we tested a combination approach to increase ROS as an effective strategy to eradicate breast CSCs and metastases. Buthionine sulfoximine (BSO) and auranofin (AU) were used to deplete glutathione (GSH) and inhibit thioredoxin reductase (TR), respectively, while mitochondrial-targeted decyltriphenylphosphonium (dTPP) was used to elevate ROS levels. In vitro clonogenicity assays using SUM159 cells showed that treatment with dTPP alone resulted in ,30% survival, while AU+BSO, BSO+dTPP and AU+BSO+dTPP all resulted in ,1% survival. These effects were reversible with N-acetylcysteine pre-treatment. The Aldefluor+ (CSC) population was also measured following drug treatment in vitro. dTPP or AU treatment alone resulted in ...
...A team of researchers from UCSF and UC San Diego has identified an app...Based on these results the team has received Orphan Drug Status for t...The findings which showed that auranofin inhibited growth of the para...The combination of an off-patent drug and decades of clinical safety d...,Lab,tests,show,arthritis,drug,effective,against,global,parasite,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
We prefer compounds that require metabolic activation, although standards that are active in themselves will be accepted if they have otherwise valuable properties. We require knowing the active metabolite, and we prefer compounds where the metabolite is stable and can be independently tested in order to verify the mechanism of toxicity as well as of metabolic activation in the test cell line ...
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Rick and Parker reveal that theres bad blood in the most intense conversation yet. Parker admits that his feud with Tony is often worse than whats portrayed on the show. Then, Rick and his crew lighten the mood with wild tales of life on the claim.
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Date:. May 20, 2012. Source:. University of California, San Diego Health Sciences. Summary:. An existing drug has been found to be effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.. Research by a collaborative group of scientists from UC San Diego School of Medicine, UC San Francisco and Wake Forest School of Medicine has led to identification of an existing drug that is effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.. Using a high-throughput screen for drugs developed by the research team, they discovered that auranofin -- a drug approved by the US Food and Drug Administration 25 years ago for rheumatoid arthritis -- is very effective in targeting an enzyme that protects amebae from oxygen attack (thus enhancing sensitivity of the amebae to reactive ...
Comment: The publication reports results that were obtained using a mouse model. The News Release states that a Phase I clinical trial is under way at the Mayo Clinic, but this trial isnt mentioned in the full text of the publication in Cancer Research. According to MedicineNet.com, aurothiomalate is a "gold-containing chemical (salt) used in treating rheumatoid arthritis ...
Among the twenty gold-based compounds Benoit Bertrand synthesized, two of them presented interesting selective toxicity for cancer cells compared to healthy cells and tissues and deserve further investigations as potential anticancer drugs. Currently, platinum-based compounds are present in the majority of the chemotherapeutic cocktails. However, despite their clinical success, platinum-based drugs present several limitations including numerous and severe side effects. A strategy envisaged to overcome these limitations is the replacement of platinum by other transition metals. Among the different metals tested over the years, gold compounds have been shown to be promising as they can overcome resistance to cisplatin due to their different modes of action. In his thesis, Bertrand presents the synthesis of different types of gold-based complexes including gold(I)-N-heterocyclic carbenes (NHC), (C^N) cyclometalated gold(III) complexes as well as heterobimetallic complexes bearing a gold(I)-NHC ...
Low-density lipoprotein is recognized as a primary vascular risk factor. However, recent data favor apolipoprotein (apo)B and apoA-I as risk factors with higher predictive values than conventional lipids. We investigated how leisure-time physical activity relates to the serum apoB/apoA-I ratio in...
PRIMARY OBJECTIVES: I. To determine the maximally tolerated dose (MTD) of ATM (gold sodium thiomalate) plus sirolimus. SECONDARY OBJECTIVES: I. To describe the adverse event profile associated with this treatment combination. II. To preliminarily evaluate the response rate, time to progression, progression-free survival and overall survival of patients treated with this treatment combination. TERTIARY OBJECTIVES: I. To evaluate tumor biomarkers of protein kinase C (PKCι) and mammalian Target Of Rapamycin (mTOR) signaling activity as predictors of response to ATM/sirolimus therapy. II. To evaluate the use of surrogate biomarkers of PKCι and mTOR inhibition in peripheral blood lymphocytes (PBLs) to monitor response to ATM/sirolimus therapy. OUTLINE: This is a dose-escalation study. Patients receive sirolimus orally (PO) once daily (QD) on days 1-28 and gold sodium thiomalate intramuscularly (IM) on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or ...
Physician reviewed gold sodium thiomalate patient information - includes gold sodium thiomalate description, dosage and directions.
Looking for gold sodium chloride? Find out information about gold sodium chloride. sodium gold chloride Explanation of gold sodium chloride
0137] The at least one used anti-inflammatory, antiproliferative, antiangiogenic, antirestenotic (anti-restenosis), antineoplastic, antimigrative and/or antithrombogenic active agent is preferably selected from the group comprising or consisting of: abciximab, acemetacin, acetylvismione B, aclarubicin, ademetionine, adriamycin, aescin, afromosone, akagerine, aldesleukin, amidorone, aminoglutethimide, amsacrine, anakinra, anastrozole, anemonin, anopterine, antimycotics, antithrombotics, apocymarin, argatroban, aristolactam-All, aristolochic acid, ascomycin, asparaginase, aspirin, atorvastatin, auranofin, azathioprine, azithromycin, baccatin, bafilomycin, basiliximab, bendamustine, benzocaine, berberine, betulin, betulinic acid, bilobol, bisparthenolidine, bleomycin, bombrestatin, Boswellic acids and its derivatives, bruceanol A, B and C, bryophyllin A, busulfan, antithrombin, bivalirudin, cadherins, camptothecin, capecitabine, o-carbamoyl-phenoxyacetic acid, carboplatin, carmustine, celecoxib, ...
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Sodium aurothiomalate (INN, known in the United States as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern medicine. It is primarily given once or twice weekly by intramuscular injection for moderate-severe rheumatoid arthritis although it has also proven itself effective in treating tuberculosis. Its most common side effects are digestive (mostly dyspepsia, mouth swelling, nausea, vomiting and taste disturbance), vasomotor (mostly flushing, fainting, dizziness, sweating, weakness, palpitations, shortness of breath and blurred vision) or dermatologic (usually itchiness, rash, local irritation near to the injection site and hair loss) in nature, although conjunctivitis, blood dyscrasias, kidney damage, joint pain, muscle aches/pains and liver dysfunction are also common. Less commonly, it can cause GI bleeds, dry mucous ...
Schistosomiasis is a tropical disease associated with high morbidity and mortality, currently affecting over 200 million people worldwide. Praziquantel is the only drug used to treat the disease, and with its increased use the probability of developing drug resistance has grown significantly. The Schistosoma parasites can survive for up to decades in the human host due in part to a unique set of antioxidant enzymes that continuously degrade the reactive oxygen species produced by the hosts innate immune response. Two principal components of this defense system have been recently identified in S. mansoni as thioredoxin/glutathione reductase (TGR) and peroxiredoxin (Prx) and as such these enzymes present attractive new targets for anti-schistosomiasis drug development. Inhibition of TGR/Prx activity was screened in a dual-enzyme format with reducing equivalents being transferred from NADPH to glutathione via a TGR-catalyzed reaction and then to hydrogen peroxide via a Prx-catalyzed step. A fully ...
This statistic displays the top anti-rheumatics worldwide by revenue in 2016 and a projection for 2022. The drug Enbrel from Pfizer, Amgen, and Takeda is expected to generate domr 5.3 billion U.S. dollars in revenue in 2022. Anti-rheumatic drugs is used to treat and slow the progress of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that principlally attacks the joints but also impacts tissues and organs.
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Elephant specific information, if available, is in blue.. Chemistry - A water soluble gold salt, aurothioglucose contains approximately 50% gold. It is practically insoluble in alcohol and insoluble in vegetable oils. The commercial product is a 5% (50 mg/ml) suspension in sesame oil, 2% aluminum monostearate, and propylparaben is added as a preservative.. Storage/Stability/Compatibility - Protect from light and store between 15-30° C; avoid freezing. A five year expiration date is assigned after manufacture. Do not mix with any other compound when injecting.. Pharmacology - Aurothioglucose has anti-inflammatory, antirheumatic, immunomodulating, and antimicrobial (in vitro) effects. The exact mechanisms for these actions are not well understood. Gold is taken up by macrophages where it inhibits phagocytosis and may inhibit lysoso-mal enzyme activity. Gold also inhibits the release of histamine, and the production of prostaglandins. While gold does have antimicrobial effects in vitro, it is not ...
REFERENCESK. Kitamura (1981) "Therapeutic Effect of Pyritinol on Sequelae of Head Injuries" J Int Med Res 9, 215-21.. G. Dalle Ore et al (1980) "The Influence of the Administration of Pyritinol on the Clinical Course of Traumatic Coma", J Neuroserg Sci 24, 1-8.. E.M. Lemmel (1993) "Comparison of Pyritinol and Auranofin in the Treatment of Rheumatoid Arthritis" Br J Rheumatol 32, 375-82.. I. Hindmarch et al (1990) "Psychpharmacalogical Effects of Pyritinol in Normal Volunteers" Neuropsychobiol 24, 159-64.. A. Pavlik & J. Pilar (1989) "Protection of Cell Proteins Against Free-Radical Attack by Nootropic Drugs: Scavenger Effects of Pyritinol Confirmed by Electron Spin Resonance Spectroscopy" Nueropharmacol 28, 557-61.. S. Hoyer et al (1977) "Effect of Pyritinol-HCL on Blood Flow and Oxidative Metabolism of the Brain in Patients with Dementia" Arzneim Forsch/Drug Res 27, 671-74.. J. Elferink & B. de Koster (1993) "Differential Stimulation of Neutrophil Functions by Pyritinol" Int J Immunopharmac 15, ...
Gold, Chemical Element - uses, elements, examples, metal ... , Gold has been called the most beautiful of all chemical elements. Its beauty has made it ... Roman historian Pliny the Elder ( A.D. 23-79), for example, describes gold-mining locations. ... The most common compounds of gold are the tellurides.. Gold (Au) - Chemical properties, Health and Environmental ... , The most common gold compounds are auric chloride (AuCl3) and chlorauric acid ... comes from gravels and quarts veins or is associated with pyrites deposits.. Gold - Wikipedia , Gold is a chemical element with the symbol Au (from Latin: aurum) and atomic number 79, ... Less commonly, it occurs in minerals as gold compounds, often with tellurium (gold tellurides). Gold is resistant to most ... A good example is Au(CN)2, which is the soluble form of gold encountered in mining. The binary gold halides .... What are the elements and compounds of gold being mined ... , 22 Oct 2019 ... When we mine gold, we are mining GOLD: it is ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Gold-containing preparations which improve the adhesiveness, guarantee an esthetic appearance, and should make possible a saving in gold consumption are needed for the production of intermediate layers for the facings of fired on alloys in the dental art with ceramic compositions. This is accomplished with preparation that contain 50 to 94% gold powder having a particle size |30μ, 5-40% binder made of organic solvent and resin components are 1-20% of a metal powder whose particle size is greater than of the gold powder used and whose melting temperature is above that of gold.
A teenage girl who thought she was just lazy has overcome leukaemia after recognising her lethargic symptoms in a character in a Cameron Diaz film.. Alex Cooper, 17, was stunned after she noticed she was suffering the same symptoms as a character dying from cancer while watching the film My Sisters Keeper.. The film is about a young girl who is brought into the world to be a genetic match for her older sister, who suffers from acute promyelocytic leukaemia.. Alex had been suffering fatigue, numerous headaches, her stomach had swollen and she noticed bruises appearing all over her body.. She had originally put her symptoms down to being a "lazy teenager" and didnt tell anyone because she was worried about "making a fuss".. But thanks to the information in the film the academically-gifted teenager, who is aiming to study at Cambridge, finally realised she needed to see a specialist.. Alex, of Bredgar, Kent, went to see her GP in October 2010 and was diagnosed with chronic myeloid leukaemia ...
A teenage girl who thought she was just lazy has overcome leukaemia after recognising her lethargic symptoms in a character in a Cameron Diaz film.. Alex Cooper, 17, was stunned after she noticed she was suffering the same symptoms as a character dying from cancer while watching the film My Sisters Keeper.. The film is about a young girl who is brought into the world to be a genetic match for her older sister, who suffers from acute promyelocytic leukaemia.. Alex had been suffering fatigue, numerous headaches, her stomach had swollen and she noticed bruises appearing all over her body.. She had originally put her symptoms down to being a "lazy teenager" and didnt tell anyone because she was worried about "making a fuss".. But thanks to the information in the film the academically-gifted teenager, who is aiming to study at Cambridge, finally realised she needed to see a specialist.. Alex, of Bredgar, Kent, went to see her GP in October 2010 and was diagnosed with chronic myeloid leukaemia ...
Arthrisoothe Gold Tablets- joint supplements for dogs with arthritis, joint pain and stiffness. This natural pain relief remedy contains glucosamine, chondroitin, MSM and more.
usr/bin/php ,?php # Run this script by providing it with the top path of AUR. # In that path you should see a file lib/aur.inc # # This will remove files which belong to deleted packages. # # ex: php cleanup dev/aur/web # $dir = $argv[1]; if (empty($dir)) { echo "Please specify AUR directory.\n"; exit; } set_include_path(get_include_path() . PATH_SEPARATOR . "$dir/lib"); include("config.inc"); include("aur.inc"); include("pkgfuncs.inc"); exec(ls . INCOMING_DIR, $files); $count = 0; foreach ($files as $pkgname) { if (!package_exists($pkgname)) { echo Removing . INCOMING_DIR . "$pkgname\n"; system(rm -r . INCOMING_DIR . $pkgname); $count++; } } echo "\nRemoved $count directories.\n ...
usr/bin/php ,?php # Run this script by providing it with the top path of AUR. # In that path you should see a file lib/aur.inc # # This will remove files which belong to deleted packages. # # ex: php cleanup dev/aur/web # $dir = $argv[1]; if (empty($dir)) { echo "Please specify AUR directory.\n"; exit; } set_include_path(get_include_path() . PATH_SEPARATOR . "$dir/lib"); include("config.inc"); include("aur.inc"); include("pkgfuncs.inc"); exec(ls . INCOMING_DIR, $files); $count = 0; foreach ($files as $pkgname) { if (!package_exists($pkgname)) { echo Removing . INCOMING_DIR . "$pkgname\n"; system(rm -r . INCOMING_DIR . $pkgname); $count++; } } echo "\nRemoved $count directories.\n ...
[QUOTE=pjarpi]loved your post...but if bhabho change...what will be left in DABH...she is the one who is making the stroy interesting for viewers...[/QUOTE] True indeed...but after a while the intense level of emotional attyachar becomes a bit overwhelming. Maybe the CVs can focus on developing ... | Page: 2 | 3403798 | Diya Aur Baati Hum Forum
In Gulabo Sitabo, Fatima Mahal is both, a character and the set it is the stage that carries, encases and showcases its cast of characters
Two placebo-controlled studies, involving a total of 81 individuals with rheumatoid arthritis, found significant reductions in swelling and pain over the course of 3 months. A comparative study in 60 arthritic patients over 6 months showed that Boswellia extract produced symptomatic benefits comparable to oral gold therapy in arthritic patients. According to a recent review of unpublished studies, preliminary double-blind trials have found Boswellia to be effective in relieving the symptoms of rheumatoid arthritis. ...
Research indicates that physical activity not only helps prevent cancer (29, 30), it also confers mortality benefits for cancer survivors (31, 32). Yet, current cancer therapies do not address the association of lifestyle factors on prognosis and survivorship, despite the fact that obesity, weight gain, and physical inactivity are common in cancer patients before and after a cancer diagnosis (33). There is a strong association between having a higher body mass index (BMI) before cancer diagnosis and mortality from different cancer types. For instance, uterine cancer survivors who had a prediagnosis BMI greater than 35 have a 6-fold increase risk of mortality compared with survivors who had a prediagnosis BMI less than 25 (34). In early-stage breast cancer, a BMI greater than or equal to 40 is associated with at least a 5-fold increase of mortality risk compared with BMI less than 25 (35). Furthermore, a higher BMI may explain up to 14% and 20% of all deaths from cancer in men and women, ...
A University of Kentucky chemist says he will do tests to see if gold salts might help children with autism -- two weeks after this column reported that the fir