Background: Hippocampal atrophy on magnetic resonance imaging (MRI) is an early characteristic of Alzheimers disease. However, hippocampal atrophy may also occur in other dementias, such as frontotemporal lobar degeneration (FTLD).. Objective: To investigate hippocampal atrophy on MRI in FTLD and its three clinical subtypes, in comparison with Alzheimers disease, using volumetry and a visual rating scale.. Methods: 42 patients with FTLD (17 frontotemporal dementia, 13 semantic dementia, and 12 progressive non-fluent aphasia), 103 patients with Alzheimers disease, and 73 controls were included. Hippocampal volumetry and the easily applicable medial temporal lobe atrophy (MTA) rating scale were applied to assess hippocampal atrophy.. Results: Multivariate analysis of variance for repeated measures showed an effect of diagnostic group on hippocampal volume. There was a significant diagnosis by side (left v right) interaction. Both FTLD and Alzheimers disease showed hippocampal atrophy compared ...
Lewis, EB, Barnes, J, Scahill, RI, Boyes, RG, Frost, C, Rossor C, , rossor, MN and Fox, NC (2004) Differentiating AD from aging using semi-automated measurment of hippocampal atrophy rates ...
Objective: To characterize and quantify the patterns of temporal lobe atrophy in AD vs semantic dementia and to relate the findings to the cognitive profiles. Medial temporal lobe atrophy is well described in AD. In temporal variant frontotemporal dementia (semantic dementia), clinical studies suggest polar and inferolateral temporal atrophy with hippocampal sparing, but quantification is largely lacking. Methods: A volumetric method for quantifying multiple temporal structures was applied to 26 patients with probable AD, 18 patients with semantic dementia, and 21 matched control subjects. Results: The authors confirmed the expected bilateral hippocampal atrophy in AD relative to controls, with involvement of the amygdala bilaterally and the right parahippocampal gyrus. Contrary to expectations, patients with semantic dementia had asymmetric hippocampal atrophy, more extensive than AD on the left. As predicted, the semantic dementia group showed more severe involvement of the temporal pole ...
Alzheimers disease (AD) is characterized by neurofibrillary tangle and neuropil thread deposition, which ultimately results in neuronal loss. A large number of magnetic resonance imaging studies have reported a smaller hippocampus in AD patients as compared to healthy elderlies. Even though this difference is often interpreted as atrophy, it is only an indirect measurement. A more direct way of measuring the atrophy is to use repeated MRIs within the same individual. Even though several groups have used this appropriate approach, the pattern of hippocampal atrophy still remains unclear and difficult to relate to underlying pathophysiology. Here, in this longitudinal study, we aimed to map hippocampal atrophy rates in patients with AD, mild cognitive impairment (MCI) and elderly controls. Data consisted of two MRI scans for each subject. The symmetric deformation field between the first and the second MRI was computed and mapped onto the three-dimensional hippocampal surface. The pattern of atrophy rate
Alzheimers disease (AD) is characterized by neurofibrillary tangle and neuropil thread deposition, which ultimately results in neuronal loss. A large number of magnetic resonance imaging studies have reported a smaller hippocampus in AD patients as compared to healthy elderlies. Even though this difference is often interpreted as atrophy, it is only an indirect measurement. A more direct way of measuring the atrophy is to use repeated MRIs within the same individual. Even though several groups have used this appropriate approach, the pattern of hippocampal atrophy still remains unclear and difficult to relate to underlying pathophysiology. Here, in this longitudinal study, we aimed to map hippocampal atrophy rates in patients with AD, mild cognitive impairment (MCI) and elderly controls. Data consisted of two MRI scans for each subject. The symmetric deformation field between the first and the second MRI was computed and mapped onto the three-dimensional hippocampal surface. The pattern of atrophy rate
Looking for Central progressive retinal atrophy? Find out information about Central progressive retinal atrophy. 1. a. of or relating to the central nervous system b. of or relating to the centrum of a vertebra 2. directed from or towards a point Explanation of Central progressive retinal atrophy
Introduction: Weight loss has been described in 20% to 45% of patients with Alzheimers disease (AD) and has been associated with adverse outcomes. Various mechanisms for weight loss in AD patients have been proposed, though none has been proven. This study aimed to elucidate a mechanism of weight loss in AD patients by examining the hypothesis that weight loss is associated with medial temporal lobe atrophy (MTA). Methods: Patients from the Frisian Alzheimers disease cohort study (a retrospective, longitudinal study of 576 community-dwelling AD patients) were included when a brain MRI was performed on which MTA could be assessed. To investigate the hypothesis that weight loss is associated with MTA, we investigated whether the trajectory of body weight change depends on the severity of MTA at the time of diagnosis (that is baseline). We hypothesized that patients with more severe MTA at baseline would have a lower body weight at baseline and a faster decrease in body weight during the course of ...
TY - JOUR. T1 - Focal atrophy in dementia with Lewy bodies on MRI. T2 - A distinct pattern from Alzheimers disease. AU - Whitwell, Jennifer Lynn. AU - Weigand, Stephen D.. AU - Shiung, Maria M.. AU - Boeve, Bradley F. AU - Ferman, Tanis Jill. AU - Smith, Glenn E.. AU - Knopman, David S. AU - Petersen, Ronald Carl. AU - Benarroch, Eduardo E.. AU - Josephs, Keith Anthony. AU - Jack, Clifford R Jr.. PY - 2007/3. Y1 - 2007/3. N2 - Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimers disease. However, unlike the latter, the patterns of cerebral atrophy associated with DLB have not been well established. The aim of this study was to identify a signature pattern of cerebral atrophy in DLB and to compare it with the pattern found in Alzheimers disease. Seventy-two patients that fulfilled clinical criteria for probable DLB were age- and gender-matched to 72 patients with probable Alzheimers disease and 72 controls. Voxel-based morphometry (VBM) was ...
Posterior Cortical Atrophy disease dementia is a type of dementia, related to Alzheimers disease. Learn about Posterior Cortical Atrophy disease signs and symptoms and treatment and get support resources.
TY - JOUR. T1 - The pattern of gray matter atrophy in Parkinsons disease differs in cortical and subcortical regions. AU - Lewis, Mechelle M.. AU - Du, Guangwei. AU - Lee, Eun Young. AU - Nasralah, Zeinab. AU - Sterling, Nicholas W.. AU - Zhang, Lijun. AU - Wagner, Daymond. AU - Kong, Lan. AU - Tröster, Alexander I.. AU - Styner, Martin. AU - Eslinger, Paul J.. AU - Mailman, Richard B.. AU - Huang, Xuemei. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Cortical and subcortical gray matter (GM) atrophy may progress differently during the course of Parkinsons disease (PD). We delineated and compared the longitudinal pattern of these PD-related changes. Structural MRIs and clinical measures were obtained from 76 PD with different disease durations and 70 Controls at baseline, 18-, and 36 months. Both cortical and subcortical (putamen, caudate, and globus pallidus) GM volumes were obtained, compared, and associated with PD clinical measures at baseline. Their volumes and rates of change also were compared ...
This effect of relapses on the survival curve is a major confounder and is the reason why I believe that to claim that a particular drug has impact on disability progression it also need to impact on the average EDSS scores across the study and have an impact on objective MRI measures that we have linked to disease progression, for example brain atrophy. I am therefore very impressed that 38% of readers of this blog rated brain atrophy as the most important outcome measure for a DMT. I am not sure in myself that it should be rated this highly at this point in time, simply because we still have a lot for us to learn about its meaning and role in MS. Despite this brain atrophy does offer us a window into the brain and probably correlates with neuroprotective effects of DMTs. This is why DMTs that have a positive impact on brain atrophy are more-than-likely to have a positive impact on long-term disability progression, the outcome measure that is the most important to MSers." ...
In most cases, advanced renal atrophy is one sign of kidney failure or ESRD. From this point, patients usually try to find out best treatment for advanced renal atrophy.
TY - JOUR. T1 - A regional consensus recommendation on brain atrophy as an outcome measure in multiple sclerosis. AU - Alroughani, Raed. AU - Deleu, Dirk. AU - El Salem, Khalid. AU - Al-Hashel, Jasem. AU - Alexander, K. John. AU - Abdelrazek, Mohamed Assem. AU - Aljishi, Adel. AU - Alkhaboori, Jaber. AU - Al Azri, Faisal. AU - Al Zadjali, Nahida. AU - Hbahbih, Majed. AU - Sokrab, Tag Eldin. AU - Said, Mohamed. AU - Rovira, Àlex. PY - 2016/11/24. Y1 - 2016/11/24. N2 - Background: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory and neurodegenerative processes leading to irreversible neurological impairment. Brain atrophy occurs early in the course of the disease at a rate greater than the general population. Brain volume loss (BVL) is associated with disability progression and cognitive impairment in patients with MS; hence its value as a potential target in monitoring and treating MS is discussed. Methods: A group of MS neurologists and neuro-radiologists ...
A new study by UMRAM researchers Professor Kader Karlı Oguz and Arzu Ceylan Has has been published in Multiple Sclerosis and Related Disorderss November issue. In this study, the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline were investigated. For this purpose thirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner.. In this study, It has been found that disease duration and educational years had contributions to some of the cognitive test scores, while age affected some volumetric measures of the brain. So while analyzing the correlations between test performances and volumetric measures, our researchers has controlled these ...
While they did not observe a statistically significant correlation between whole-gray matter volumes and the EDSS scores, they did discover an inverse correlation between whole-gray matter volumes and the EDSS bowel and bladder functional system subscore and between gray matter volumes and the EDSS cerebellar functional system subscore. Less gray matter volume was correlated with more disability, they said.. "Although several studies have reported that gray matter atrophy is associated with EDSS scores, others have not found such a correlation," the researchers said. "The difference in our observations again may be owing to differences in our patient populations.". The study had a number of limitations, including the fact that the cohort consisted entirely of untreated female patients with RRMS. The findings may have been different if the patient population had been male or if the patients had progressive MS, they noted.. The researchers called for further longitudinal studies with larger ...
Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimers disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y. Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe. In the placebo group, higher homocysteine levels at baseline are associated with faster GM atrophy, but this deleterious effect is largely prevented by B-vitamin treatment. We additionally show that the beneficial effect of B vitamins is
Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimers disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y. Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe. In the placebo group, higher homocysteine levels at baseline are associated with faster GM atrophy, but this deleterious effect is largely prevented by B-vitamin treatment. We additionally show that the beneficial effect of B vitamins is
The beneficial effect of B vitamin treatment on brain atrophy was observed only in subjects with high plasma ω-3 fatty acids. It is also suggested that the beneficial effect of ω-3 fatty acids on brain atrophy may be confined to subjects with good B vitamin status. The results highlight the importan …
Methods Serum and CSF levels of anti-Aβ autoantibodies and CSF biomarkers were evaluated in 68 patients with cognitive impairment, comprising 44 patients with AD, 19 patients with amnestic MCI and five patients with non-Alzheimers dementia. The degree of brain atrophy was assessed using the voxel-based specific regional analysis system for AD, which targets the volume of interest (VOI) in medial temporal structures, including the whole hippocampus, entorhinal cortex and amygdala. ...
In the current study, pathologic classification of DLB was made according to the likelihood classification proposed by the Third Report of the DLB Consortium criteria.6 Using this classification scheme, antemortem MRI hippocampal volumes in patients with high likelihood DLB were indistinguishable from those of control subjects (i.e., individuals with low likelihood AD and no LB-related pathology), whereas low and intermediate likelihood DLB groups showed significantly smaller hippocampal volumes during life. Moreover, within the DLB pathologic groups, there was a significant stepwise relationship with greater hippocampal volume from low to intermediate to high likelihood DLB.. These findings are in agreement with the reports on preservation of hippocampal volumes in patients with clinically diagnosed and pathologically confirmed DLB.15,17,28 The current data also show a relationship between hippocampal volume and Braak NFT stage in patients with DLB, suggesting that hippocampal volume is ...
TY - JOUR. T1 - Visual impairment in posterior cortical atrophy and dementia with lewy bodies. AU - Metzler-Baddeley, Claudia. AU - Baddeley, Roland J. AU - Lovell, P George. AU - Jones, Roy W. PY - 2009. Y1 - 2009. U2 - 10.1016/j.jalz.2009.04.862. DO - 10.1016/j.jalz.2009.04.862. M3 - Meeting Abstract. VL - 5. SP - P458. JO - Alzheimers Dementia: The Journal of the Alzheimers Association. JF - Alzheimers Dementia: The Journal of the Alzheimers Association. IS - 4, Suppl.. ER - ...
Learn more about Posterior Cortical Atrophy causes, sign and symptoms, treatment and diagnosis at FindaTopdoc. Read more information on homeopathic remedies, risks, and prevention.
It is necessary to understand the symptoms of kidney atrophy! There is no denying the fact that this is a problem for all the people. The confirmation of renal atrophy is an inalienable association for the selection of renal atrophy and hea
Mild cognitive impairment (MCI) often represents a prodromal form of dementia, conferring a significantly higher risk of converting to probable Alzheimers disease (AD). The aim of this study is to characterise the differences of grey matter (GM) distribution and dynamics between progressive and stable MCI subjects during a 2 year period preceding the conversion to AD. We included 48 stable MCI and 12 progressive MCI cases based on the availability of 3 serial scans acquired with approximately 1 year scan interval. For the progressive MCI group, the third scan was acquired at the time of the clinical diagnosis of AD, while the first two scans were acquired approximately 2 and 1 years earlier. For the stable MCI group, the three scans were acquired at approximately 1 year intervals during a period free from significant cognitive decline. We used longitudinal voxel-based morphometry (VBM) for mapping the progression of GM loss over time. For the progressive MCI group, the cross-sectional analysis ...
Differential patterns of spinal cord and brain atrophy in NMO and MS.: NMO showed predominately spinal cord atrophy with mild brain atrophy, while MS demonstrat
Cognitive impairment may result in significant disability in patients with Multiple Sclerosis (MS). Previous Magnetic Resonance Imaging (MRI) studies on cognition in MS were mainly based on measures of gross brain involvement. This study, using voxel-based morphometry (VBM), aims to investigate associations between the regional distribution of grey matter (GM) damage and cognitive performance in patients with MS. Eighteen MS patients underwent an extensive neuropsychological battery and MRI, including T2-weighted scans and T1-weighted volumes. A group of 18 healthy individuals were also investigated by MRI and served as controls for the VBM. A cross-sectional analysis was first performed, to assess the pattern of regional GM atrophy in MS patients. Then, the impact of regional GM damage on patients neuropsychological performance was investigated by multiple regression analyses in the patient group. Correlations between global indexes of brain damage and neuropsychological measures were also ...
Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection Rieko Okada,1 Takashi Okada,2 Akira Okada,2 Hideyuki Muramoto,3 Masahisa Katsuno,4 Gen Sobue,4 Nobuyuki Hamajima11Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 2Okada Medical Clinic, 3Muramoto Clinic, 4Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, JapanBackground: The purpose of this study is to determine whether elderly subjects with severe brain atrophy, which is associated with neurodegeneration and difficulty swallowing (dysphagia), are more susceptible to lower respiratory tract infections (LRTI), including pneumonia.Methods: The severity of brain atrophy was assessed by computed tomography in 51 nursing home residents aged 60-96 years. The incidence of LRTI, defined by body temperature ≥38.0°C, presence of two or more respiratory symptoms, and use of antibiotics, was determined over 4 years. The incidence of LRTI was compared according
Based upon the principles narrated below, the doctors and TCM experts working in Chaoyang TCM Brain Atrophy Treatment Hospital spent more than ten years in experiment and clinical application, and gained their success with the successful research result of Brain Atrophy Recovery Pill. More than 7 years of clinical experiments verified its effective rate as high as 93% in treating brain atrophy and dementia. The following are general principles adopted widely in formula invention process:. ...
Question - Diagnosed with brain atrophy. Inserted feeding tube. How does brain atrophy occur and what is life expectancy?, Ask a Neurologist
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Aim: Type 2 diabetes mellitus (T2D) is associated with gray matter atrophy. Adiposity and physical inactivity are risk factors for T2D and brain atrophy. We studied whether the associations of T2D with total gray matter volume (GMV) and hippocampal volume (HV) are dependent on obesity and physical activity. Materials and Methods: In this cross-sectional study, we measured waist-hip ratio (WHR), body mass index (BMI), mean steps/day and brain volumes in a community dwelling cohort of people with and without T2D. Using multivariable linear regression, we examined whether WHR, BMI and physical activity mediated or modified the association between T2D, GMV and HV. Results: There were 258 participants with (mean age 67±7 years) and 302 without (mean age 72±7 years) T2D. Adjusting for age, sex and intracranial volume, T2D was independently associated with lower total GMV (p = 0.001) and HV ( ...
Progressive retinal atrophy (PRA) is a name given to a group of eye diseases of similar character. PRA causes no pain or discomfort but may result in permanent blindness. The word atrophy means wasting away. PRA develops after birth and in some breeds has been determined to be inherited from both parents. It affects the retina, which lines the back portion of the inside of the eye. The retina contains the light-sensitive rods and cones that change light into energy for transmitting messages to the brain. The retina is similar to the film in a camera; the image or picture is received on it. PRA can occur in all breeds of dogs although certain breeds are at higher risk. It appears earlier in some breeds and can take several years to cause complete blindness. An early sign of PRA is inability to see in dim light or at night. For example, an animal with PRA may hesitate to go from a well-lighted room into a darkened room. Due to PRAs slow progress, most pets adapt very well to the gradual loss of ...
Diagnosis Code K08.26 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
To evaluate the aspect of the vaginal mucosa and the local tolerance to DHEA suppository, the vaginal epithelial surface thickness(one of the four main signs of vaginal atrophy) evaluated by the physician/gynecologist as corresponding to none, mild, moderate, or severe atrophy was analyzed using the score values of 1, 2, 3 and 4, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented ...
Looking for healed yellow atrophy? Find out information about healed yellow atrophy. diminution in the size of a cell, tissue, or organ from its fully developed normal size. Temporary atrophy may occur in muscles that are not used, as when a... Explanation of healed yellow atrophy
Dung, H C. and Yu, J, "Serum protein changes in the mice with splenic atrophy, splenomegaly, or splenectomy. Abstr." (1978). Subject Strain Bibliography 1978. 2027 ...
The treatment for Testicular Atrophy is based on the underlying cause for the disease and then treating the cause. While taking the history of the individual, the physician will have knowledge of whether the individual has a prior history of medical
The following study below in which I was involved with shows that when pwMS are given chemotherapy they undergo increased neuronal loss, which is associated with worsening of their EDSS and greater brain atrophy. The data speaks for itself. The picture below is what we call a survival curve of EDSS worsening; you can see that the pwMS who had high blood levels of neurofilaments were much more likely to worsen than those who did not have raised neurofilament levels. Similarly, brain atrophy rates in pwMS were in the order of 2.1% per year in those who had a HSCT compared to only 1.2% per year in pwSPMS who did not have HSCT; the upper limit of normal for brain atrophy in healthy adults is generally accepted to be 0.4% per year. The bottom line is that if you have SPMS HSCT is likely to accelerate your disease worsening. As a result of these and similar observations most units have stopped doing HSCT in people with more advanced MS. However, with the advent of highly-effective DMTs such as ...
The following study below in which I was involved with shows that when pwMS are given chemotherapy they undergo increased neuronal loss, which is associated with worsening of their EDSS and greater brain atrophy. The data speaks for itself. The picture below is what we call a survival curve of EDSS worsening; you can see that the pwMS who had high blood levels of neurofilaments were much more likely to worsen than those who did not have raised neurofilament levels. Similarly, brain atrophy rates in pwMS were in the order of 2.1% per year in those who had a HSCT compared to only 1.2% per year in pwSPMS who did not have HSCT; the upper limit of normal for brain atrophy in healthy adults is generally accepted to be 0.4% per year. The bottom line is that if you have SPMS HSCT is likely to accelerate your disease worsening. As a result of these and similar observations most units have stopped doing HSCT in people with more advanced MS. However, with the advent of highly-effective DMTs such as ...
There has been a resurgence of the degenerative eye disease, Progressive Retinal Atrophy in recent years, having been fairly dormant for the past twenty y...
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RESULTS:Significantly less GM atrophy (during year two), but not WM atrophy (at any point), was observed with IM IFN beta-1a compared with placebo. Pseudoatrophy effects were more apparent in WM than in GM; in year one, greater WM volume loss was observed with IM IFN beta-1a than with placebo, whereas GM volume loss was similar between groups. Risk of sustained disability progression was significantly associated with GM, but not WM, atrophy ...
Legal Age The age at which a child can be left at home alone is only legislated in two states, Maryland and Illinois. The legal check is whether or not the child is safe and has the ability to take care of themselves. Most authorities agree that leaving a 12 year old alone at home for an hour or two is acceptable, but they should not be responsible for other children. Legal Age There are very few states in the U.S. with legal minimum ages, but many state agencies have published guidelines (Georgia, Illinois, Maryland and Oregon are a few of the states with very specific ages). Typically 8 year olds and over can be left at home for up to se...
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Cerebral atrophy. Cortical-sub-cortical parietal atrophy as a result of an ischemic stroke, seen in a radial section MRI. - Stock Image C026/8791
1. Introduction. Microvillous inclusion disease (MVD) or microvillous atrophy disorder is a congenital disorder of the small intestinal epithelial cells that presents with persistent and severe diarrhea and it is characterized by enterocyte abnormalities [1] . The diarrhea starts in the first 72 hours of life (early onset form) or in 6 to 8 weeks after birth (late onset) [2] . This inheritance of MVD appears to be autosomal recessive, based on cases occurring in siblings and high incidence of consanguinity [3] . Molecular studies demonstrate mutation of the MYO5B that encoded for myosin 5b has a role in pathogenesis of the MVD [4] . Diagnosis is often delayed because of difficulties in taking a small bowl biopsy specimen in the neonatal period. Light microscopy shows enteropathy, and severe atrophy of the enterocytes brush borders, with instead of, accumulation of Periodic Acid Schiff (PAS) and CD10 positive granules at the apical pole of immature enterocytes [1] . Transmission electron ...
Cerebral atrophy is the morphological presentation of brain parenchymal volume loss that is frequently seen on cross sectional imaging. Rather than being a primary diagnosis, it is the common endpoint for range disease processes that affect the c...
Thus, the seeming age-related atrophy in gray matter more likely reflected pathological changes in the brain that underlie significant cognitive decline than aging itself, the authors wrote. As long as people stay cognitively healthy, the researchers believe that the gray matter of areas supporting cognition might not shrink much at all. "If future longitudinal studies find similar results, our conception of normal brain aging may become more optimistic," said lead author Saartje Burgmans, who is due to receive her PhD later this year.. The findings should caution scientists about drawing conclusions from brain studies that dont screen participants over time, using precise and objective definitions, the authors added.. Article: "The Prevalence of Cortical Gray Matter Atrophy May Be Overestimated In the Healthy Aging Brain," Saartje Burgmans, PhD student, Martin P. J. van Boxtel, PhD, MD, Eric F. P. M. Vuurman, PhD, Floortje Smeets, PhD student, and Ed H. B. M. Gronenschild, PhD, Maastricht ...
Half of the patients with SCD had SVD to some extent, but severe SVD was rare. Although the majority of the patients with SVD remained stable over 3 years, patients with severe WMH had a 4-fold higher risk to show clinical progression to mild cognitive impairment or dementia, compared with patients without WMH. In addition, increasing WMH severity was associated with decline on memory, attention, executive functioning, and global cognition. These associations were independent of age and medial temporal lobe atrophy; 2 factors that previously have been pointed out as strong predictors for mild cognitive impairment and dementia.6-9 Our results seem in line with findings from the Leukoaraiosis and Disability study, in which a heterogeneous population of nondisabled elderly with WMH was included.10 We are, however, the first to show this in patients presenting with SCD to a memory clinic.. A major strength of this study is the longitudinal design with substantial follow-up in a well-characterized ...