1. The effect of a α-human atrial natriuretic peptide (1-28) (ANP) on human vasculature was investigated in vivo and in vitro. Possible involvement of vascular dopamine receptors and the renin-angiotensin system in the response to ANP was also studied in vivo.. 2. Forearm blood blow was measured by venous occlusion plethysmography. Isolated human blood vessels were studied using conventional organ bath techniques.. 3. ANP (0.1-1 μg/min, intra-arterially) produced a dose-dependent increase in forearm blood flow, corresponding to a 163% increase in net forearm blood flow in the study arm. This action of ANP was not antagonized by (R)-sulpiride (100 μg/min, intra-arterially), a selective vascular dopamine receptor antagonist, or 50 mg of oral captopril, an inhibitor of angiotensin-converting enzyme.. 4. ANP (1 nmol/l-1 μmol/l) produced concentration-dependent relaxation of isolated human arteries, including brachial artery, but was without effect on isolated human saphenous vein.. 5. ANP ...
alpha-Human atrial natriuretic peptide, a 28-amino-acid-residue peptide, was rapidly hydrolysed by pig kidney microvillar membranes in vitro, with a t1/2 of 8 min, comparable with the rate observed with angiotensins II and III. The products of hydrolysis were analysed by h.p.l.c., the pattern obtained with membranes being similar to that with purified endopeptidase-24.11 (EC 3.4.24.11). No hydrolysis by peptidyl dipeptidase A (angiotensin I converting enzyme, EC 3.4.15.1) was observed. The contribution of the various microvillar membrane peptidases was assessed by including specific inhibitors. Phosphoramidon, an inhibitor of endopeptidase-24.11, caused 80-100% suppression of the products. Captopril and amastatin (inhibitors of peptidyl dipeptidase A and aminopeptidases respectively) had no significant effect. Hydrolysis at an undefined site within the disulphide-linked ring occurred rapidly, followed by hydrolysis at other sites, including the Ser25--Phe26 bond. ...
Elevated plasma natriuretic peptide levels after AMI (acute myocardial infarction) are associated with adverse outcome. The aim of the present study was to examine the relationship of plasma N-ANP (N-terminal pro-atrial natriuretic peptide) and N-BNP (N-terminal pro-B-type natriuretic peptide) with mortality and heart failure following AMI. We studied 403 patients with AMI. Blood was sampled for measurement of N-ANP and N-BNP on a single occasion between 72 and 96 h after symptom onset. Natriuretic peptide levels were related to all-cause mortality and heart failure episodes. During follow up (median, 462 days; range 5-764), 43 (10.7%), 25 (6.2%) and 49 (12.2%) patients suffered death, heart failure hospitalization and outpatient heart failure respectively. Only N-BNP (P,0.0005), N-ANP (P=0.005) and previous AMI (P=0.016) were independently predictive of death. N-BNP, but not N-ANP, predicted 30-day mortality. N-ANP, but not N-BNP, predicted mortality after 30 days. N-BNP was the better ...
TY - JOUR. T1 - Atrial natriuretic polypeptide (ANP) in human ventricle increased gene expression of ANP in dilated cardiomyopathy. AU - Saito, Yoshihiko. AU - Nakao, Kazuwa. AU - Arai, Hiroshi. AU - Sugawara, Akira. AU - Morii, Narito. AU - Yamada, Takayuki. AU - Itoh, Hiroshi. AU - Shiono, Shozo. AU - Mukoyama, Masashi. AU - Obata, Kenji. AU - Yasue, Hirofumi. AU - Ohkubo, Hiroaki. AU - Nakanishi, Shigetada. AU - Imura, Hiroo. PY - 1987/10/14. Y1 - 1987/10/14. N2 - Tissue levels of atrial natriuretic polypeptide (ANP) messenger RNA (ANPmRNA) and ANP in the human atrium and ventricle were measured simultaneously by the blot hybridization technique and the specific radioimmunoassay for ANP. Hearts were obtained from two patients without cardiac complications and from a patient with dilated cardiomyopathy (DCM) at autopsy. Total RNA extracted from ventricles contained a hydridizing RNA band of the same size as atrial ANPmRNA in both control and DCM hearts. The ANPmRNA level in the control ...
Previous studies have shown that atrial natriuretic factor, a powerful vasorelaxant of precontracted vessels, inhibits the secretion of aldosterone stimulated by angiotensin II, adrenocorticotropic hormone, and potassium. We now report the presence of specific binding sites for atrial natriuretic factor in rat blood vessels (mesenteric and renal arteries) and adrenal capsules. Radioiodinated synthetic atrial natriuretic factor bound to a single class of high-affinity (KD = 0.1 nM) low-capacity receptors in a particulate fraction from blood vessels and adrenals. Unrelated peptides did not displace atrial natriuretic factor. Fragments of atrial natriuretic factor displaced the labeled ligand with decreasing potency after cleavage at the N-terminal. The cleavage of the C-terminal tyrosine did not decrease the potency of atrial natriuretic factor, but further cleavage at the C-terminal dramatically reduced the affinity of the resulting peptides. The potency of the atrial natriuretic factor fragments ...
1. The effects of the infusion of a low dose (2 pmol min−1 kg−1 for 3 h) of human atrial natriuretic peptide (hANP) were studied in seven healthy volunteers undergoing a water diuresis. Lithium clearance was used to monitor proximal tubular function.. 2. hANP increased urine flow rate, sodium, calcium and magnesium excretion without significant changes in potassium and phosphate excretion, heart rate or blood pressure.. 3. hANP caused a small change in fractional lithium clearance, and larger changes in distal nephron handling of sodium and water.. 4. Plasma renin activity tended to decrease during the infusion of hANP, while plasma aldosterone concentration decreased during and increased after stopping the infusion of hANP.. 5. The data suggest that hANP inhibits the reabsorption of sodium and water by an action on distal segments of the nephron and perhaps the proximal tubule. Inhibition of renin and aldosterone secretion may contribute to the natriuresis. ...
Plasma atrial natriuretic peptide in essential hypertension: effects of changes in dietary sodium. Sagnella, Giuseppe A.; Markandu, Nirmala D.; Buckley, Martin G.; Singer, Donald R.J.; Sugden, A. Louise; Shore, Angela C.; MacGregor, Graham A. // British Medical Journal (Clinical Research Edition);8/15/1987, Vol. 295 Issue 6595, p417 Examines the plasma atrial natriuretic peptide in essential hypertension. Effects of changes in dietary intake on plasma atrial peptides; Occurrence of change in plasma concentration of atrial peptide values during the transfer from normal to high sodium diet; Correlation between the fall in... ...
[Effects of female sex hormones on atrial natriuretic factor gene expression in rats].: To clarify the effects of female sex hormones on ANF gene expression, em
We investigated the hemodynamic effect of synthetic atrial natriuretic factor Auriculin A (ANF) and its influence on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits anesthetized with alpha-chloralose and urethane. The neural mechanisms underlying these effects were also studied. In the intact animal, a 45-minute constant infusion of ANF (2 micrograms/kg prime, 0.2 microgram/kg/min) significantly reduced mean blood pressure and increased mean perfusion pressure, while heart rate did not change. Comparable data were obtained with lower (0.5 microgram/kg + 0.05 microgram/kg/min; 1 microgram/kg + 0.1 microgram/kg/min) or higher (4 micrograms/kg + 0.4 microgram/kg/min; 8 micrograms/kg + 0.8 microgram/kg/min) doses of ANF. In addition, ANF enhanced bradycardic reflex responses to phenylephrine i.v. bolus administration, while it did not change baroreflex-mediated responses to nitroglycerin i.v. bolus ...
Definition of atrial natriuretic factor in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is atrial natriuretic factor? Meaning of atrial natriuretic factor as a finance term. What does atrial natriuretic factor mean in finance?
To explore whether pathophysiological plasma levels of atrial natriuretic peptide (ANP) actually involve sodium excretion in spontaneously hypertensive rats (SHR), we examined the in vivo and ex vivo effects of ANP and an endopeptidase inhibitor, thiorphan, on urinary sodium excretion and the elimination rate of ANP. We found the following: 1) The basal plasma ANP level was higher in 16-week-old SHR than in Wistar-Kyoto (WKY) rats (109 +/- 10 [SEM] versus 63 +/- 4 pg/ml, p less than 0.001). Thiorphan (30 mg/kg i.v.) significantly increased plasma ANP by 60% in both SHR and WKY rats. However, increases in urinary sodium excretion (+290% versus +130%, p less than 0.05) and cyclic GMP (+160% versus +60%, p less than 0.05) were greater in SHR than in WKY rats. Urinary excretion of ANP was markedly increased by thiorphan, and its increase was greater in SHR than in WKY rats. 2) The thiorphan-induced natriuresis was substantially attenuated by antiserum for ANP but not by a bradykinin receptor ...
Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury and a frequent occurrence in critically ill patients. Renal IRI releases proinflammatory cytokines within the kidney that induce crosstalk between the kidney and other organ systems. Atrial natriuretic peptide (ANP) has anti-inflammatory as well as natriuretic effects and serves important functions as a regulator of blood pressure, fluid homeostasis, and inflammation. The objective of the present study was to elucidate whether ANP post-treatment attenuates kidney-lung-heart crosstalk in a rat model of renal IRI. In experiment I, a rat model of unilateral renal IRI with mechanical ventilation was prepared by clamping the left renal pedicle for 30 min. Five minutes after clamping, saline or ANP (0.2 μg/kg/min) was infused. The hemodynamics, arterial blood gases, and plasma concentrations of lactate and potassium were measured at baseline and at 1, 2, and 3 h after declamping. The mRNA expression and localization of tumor
METHODS AND RESULTS Twenty patients with acute right ventricular infarction were examined who underwent reperfusion therapy on admission. These patients had proximal occlusion of the dominant right coronary artery involving the right atrial branches: 9 patients with successful reperfusion (SRP group) and the remaining 11 patients with unsuccessful reperfusion (URP group). Within 24 hours after the onset of infarction, a volume loading test was performed after reperfusion therapy with measurements for plasma ANP levels and hemodynamics. Before the volume loading test, the plasma ANP level and mean right atrial pressure were similar between these two groups. However, in the URP group, percent increase in ANP in response to volume loading was strikingly smaller (URP, 45 +/- 18% versus SRP, 133 +/- 25%; P , .01) despite similar percent increase in mean right atrial pressure (URP, 100 +/- 46% versus SRP, 86 +/- 23%). The peak ANP level occurred significantly later in the URP group (69 +/- 16 hours) ...
A 75-year-old Japanese man was hospitalized for hypokalemia. Levels of plasma adrenocorticotropic hormone (ACTH) and free cortisol in urine were elevated to 220 pg/mL (normal, 9 to 52 pg/mL) and 793 mg/d (normal, 30 to 100 mg/d), respectively. Blood concentration of corticotropin-releasing factor was 13.8 pg/mL (normal, ,40 pg/mL). Chest radiographs and computed tomographic examinations showed an enlarged thymic gland and normal-sized adrenal glands. Venous samplings in the superior and inferior vena cava at several levels showed markedly increased plasma atrial natriuretic peptide concentrations near the thymic tumor (from 120 to 620 pg/mL). By contrast, plasma ACTH concentrations were constant at all sites sampled. Pathologic study results were compatible with carcinoid. Immunohistochemical staining for atrial natriuretic peptides and ACTH in the dissected tumor tissue showed several cells to be positively stained for the peptides. No ACTH-containing cells were detected. After the tumor was ...
TY - JOUR. T1 - Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. AU - Campese, Vito M.. AU - Tawadrous, Medhat. AU - Bigazzi, Roberto. AU - Bianchi, Stefano. AU - Mann, Amardeep S.. AU - Oparil, Suzanne. AU - Raij, Leopoldo. PY - 1996/9. Y1 - 1996/9. N2 - In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt- sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive ...
The aim of the present study was to determine whether left atrial size--a likely indicator of atrial stretching--correlates with the plasma concentration of atrial natriuretic peptide and whether this relation is different in patients in sinus rhythm and in those with atrial fibrillation. Arterial plasma concentrations of immunoreactive atrial natriuretic peptide (ir-ANP), adrenaline, noradrenaline, aldosterone, and vasopressin were measured in 13 patients in sinus rhythm without apparent heart failure and in 13 patients in atrial fibrillation. The two groups were matched for left atrial diameter and the ratio of the left atrial diameter to the diameter of the aortic root (assessed by echocardiography). There were no significant differences in age, heart rate, blood pressure, or left ventricular end diastolic diameter between the two groups. Left atrial diameters varied from 33 to 60 mm. The mean (SD) plasma concentration of ir-ANP was significantly higher (35 (21) pmol/l) in the patients with ...
The influence of physiological cardiac hypertrophy on the concentration of plasma atrial natriuretic peptide was studied in six male athletes and six normally active, matched control men. They were examined by echocardiography during a graded exercise test on a bicycle ergometer. Plasma atrial natriuretic peptide was measured at rest, at each workload until exhaustion, and 15 and 30 minutes after the exercise test. Echocardiography showed that the athletes had a significantly larger left atrium, left ventricular end diastolic diameter, left ventricular posterior wall, interventricular septum, left ventricular ejection fraction, and left ventricular mass than the controls. The athletes performed significantly more work than the control group--325 W v 277 W. The plasma concentration of atrial natriuretic peptide rose by a mean factor of 2.76 (range 1.78-4.28) in all men from rest to maximum exercise. There were no differences between the athletes and the controls in the concentrations of plasma ...
Synonyms for Atrial natriuretic peptide in Free Thesaurus. Antonyms for Atrial natriuretic peptide. 4 words related to peptide: amide, fibrinopeptide, polypeptide, endorphin. What are synonyms for Atrial natriuretic peptide?
The effects of acute volume expansion and acute salt loading on the plasma levels of immunoreactive atrial natriuretic peptides (ir-ANPs) were investigated in conscious adult (16 weeks) Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Basal plasma concentrations of ir-ANPs were similar (108 +/- 9 pg/ml and 105 +/- 8 pg/ml, respectively) in hypertensive and normotensive rats. In both strains mean arterial pressure, heart rate and plasma catecholamines were unaltered by acute volume expansion but significantly elevated by acute salt loading. However, both acute volume expansion and acute salt loading increased plasma concentrations of ir-ANPs similarily in SHR and WKY rats, independent of blood pressure or plasma catecholamine levels. Our findings show that chronic hypertension in SHR does not result in changes in basal or VOL- and SAL-stimulated levels of circulating ir-ANPs.
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திறன்மிகு நாள விரிப்பியான (Vasodilator) இதயியச் சோடியச்சிறுநீர்மைப் புரதக்கூறு [Atrial natriuretic peptide; (ANP), atrial natriuretic factor; (ANF), atrial natriuretic hormone; (ANH), Cardionatrine, Cardiodilatine; (CDD), atriopeptin], இதயத்தசைச் செல்களால் சுரக்கப்படும் புரதக்கூற்று இயக்குநீராகும்[2][3][4]. இப்புரதக்கூறானது உடலின் நீர், சோடியம், பொட்டாசியம், கொழுப்புத் திசுக்களில் உள்ள கொழுப்பு ஆகியவற்றின் சமநிலையைக் கட்டுபடுத்துவதில் ஈடுபட்டுள்ளது; இரத்தத்தின் கன அளவு ...
The clinical significance of cardiac Natriuretic Peptides (cNP) plasma levels has been shown to differ in obese and non-obese subjects. Recent lines of evidence suggest important metabolic effects of the cNP system, which has been shown to activate lipolysis, enhance lipid oxidation and mitochondrial respiration. Clinically, these properties lead to browning of white adipose tissue and to increased muscular oxidative capacity. In patients without heart disease higher cNP concentrations were observed in lean, insulin-sensitive subjects, while obese and type-2 diabetics may display reduced cNP levels.
Occurrence of a novel cardiac natriuretic peptide in rats.: We established a specific radioimmunoassay for the ring structure of iso-ANP and detected iso-ANP[
TY - JOUR. T1 - Atrial natriuretic factor modulates whole kidney tubuloglomerular feedback. AU - Margulies, K. B.. AU - Burnett, John C Jr.. PY - 1990. Y1 - 1990. N2 - Increases in sodium delivery to the distal nephron reduce glomerular filtration rate (GFR) via tubuloglomerular feedback (TGF). Central volume expansion and pharmacological concentrations of atrial natriuretic factor (ANF) are known to attenuate this response. To test the hypothesis that whole kidney TGF is attenuated by pathophysiological concentrations of ANF, hypertonic saline was given intrarenally in five dogs receiving an intravenous infusion of synthetic ANF at 20 ng·kg-1·min-1. To examine whole kidney TGF responses in heart failure, six additional dogs with acute congestive heart failure induced by rapid ventricular pacing also received intrarenal hypertonic saline. Seven sham-paced dogs served as controls. An isolated increase in circulating ANF from 26 ± 3 to 342 ± 23 pg/ml abolished the whole kidney GFR response to ...
BACKGROUND: Natriuretic peptides are currently used in the diagnosis and follow-up of patients with Chronic Heart Failure (CHF). However, it is unknown whether there are different influences of age on atrial natriuretic peptide (ANP)/N-terminal-ANP (NT-ANP) or B-type natriuretic peptide (BNP)/N-terminal-proBNP (NT-proBNP). AIMS: To compare the influence of age and gender on plasma levels of ANP/NT-ANP and BNP/NT-proBNP in CHF patients. METHODS AND RESULTS: Natriuretic peptides were measured in 311 CHF patients (68+/-8 years, 76% males, left ventricular ejection fraction (LVEF) 0.23+/-0.08). All natriuretic peptides were significantly related to age (p,0.05) on multivariate regression analysis, with partial correlation coefficients of 0.18, 0.29, 0.28 and 0.25 for ANP, NT-ANP, BNP and NT-proBNP, respectively. The relative increase of both BNP/NT-proBNP were more pronounced than of ANP/NT-ANP (p,0.01). Furthermore, the relative increase of BNP with age was markedly larger than of NT-proBNP ...
The role of atrial natriuretic factor (ANF) in modulating volume and circulatory homeostasis remains uncertain, and there has been as yet no systematic analysis of the factors promoting ANF release in humans. Since immersion in water to the neck provides a volume stimulus identical to that induced by 2 litres of saline, without plasma compositional change, immersion to the neck was used to assess the ANF response to acute central blood-volume expansion. Using a radio-immunoassay that reliably detected ANF in human plasma extracts, more than 80% of plasma immunoreactive (ir) ANF was shown to elute as a single peak on reverse-phase high performance liquid chromatography, with a retention time identical to that of the synthetic 28-residue alpha-human (alpha-h) ANF. The response of plasma irANF to 3 h of immersion in water to the neck was evaluated in four sodium-replete normal subjects; the immersion produced a prompt and marked increase in irANF in each subject, and recovery was associated with a prompt
BACKGROUND--Plasma levels of atrial natriuretic peptide (ANP) are elevated in patients with chronic obstructive pulmonary disease (COPD) and may have a role in preventing oedema formation in these patients. METHODS--Plasma ANP levels were measured in 60 patients with COPD and these measurements were related to pulmonary haemodynamics, response to treatment during exacerbations, and clinical patterns of the stable disease. RESULTS--Plasma ANP levels did not correlate significantly with right atrial or pulmonary arterial pressures but did correlate significantly with both the right ventricular end diastolic volume and right ventricular wall volume measured by magnetic resonance imaging. Oxygen (2 1/min by nasal prongs for 30 minutes) did not change the mean pulmonary arterial pressure or the level of plasma ANP. In 20 patients with an acute exacerbation of COPD plasma ANP levels were higher in those with oedema (302 (185) pg/ml) than in those without oedema (87 (43) pg/ml). Oxygen given for one ...
TY - JOUR. T1 - Cardio-renal-endocrine dynamics during stepwise infusion of physiologic and pharmacologic concentrations of atrial natriuretic factor in the dog. AU - Zimmerman, R. S.. AU - Schirger, J. A.. AU - Edwards, B. S.. AU - Schwab, T. R.. AU - Heublein, D. M.. AU - Burnett, J. C.. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Infusion of α-human-atrial natriuretic factor (α-h-ANF) into pentobarbitol anesthesized dogs (n = 10) at 0.0025, 0.005, 0.01, and 0.3 μg/kg/min was performed to differentiate the physiologic actions of atrial natriuretic factor from its pharmacologic actions. The lowest doses of atrial natriuretic factor infusion resulted in circulating levels that were previously produced by 0-10% saline volume expansion. At the lowest infusion rate, circulating ANF increased 31 ± 3 pg/ml, resulting in a significant increase in absolute sodium excretion, fractional excretion of sodium, and fractional excretion of lithium, and a significant decrease in urine osmolality. A greater change ...
DRJ Singer, ND Markandu, MG Buckley, AC Shore, AL Sugden, M Jeeves, GA Sagnella, GA Macgregor; Infusion of Atrial Natriuretic Peptide in Essential Hypertension: Antihypertensive Effects are Dissociated from Plasma Anp Levels and Urinary Sodium Excretion. Clin Sci (Lond) 1 January 1988; 74 (s18): 65P. doi: https://doi.org/10.1042/cs074065Pb. Download citation file:. ...
The physiological actions of the atrial peptide system are discussed in relation to its potential role in the aetiology and treatment of hypertension and congestive heart failure (CHF). Atrial natriuretic factor (ANF) exerts marked natriuretic, diure
To evaluate the role of calcium in volume-induced secretion of atrial natriuretic factor (ANF), effects of verapamil and endothelin-1 (ET-1), both known to influence free intracellular calcium, were studied during saline infusion in seven conscious instrumented dogs. Fifteen minutes after intravenous injection of placebo or verapamil (0.25 mg/kg) or during continuous ET-1 infusion (at 5 ng.kg-1.min-1), saline (10% body wt) was infused during 40 min. Saline produced a rise (P less than 0.001) of plasma ANF from 28.1 +/- 6.3 to 50.4 +/- 12.9 pM after placebo, from 30.2 +/- 6.1 to 51.1 +/- 8.5 pM after verapamil, and from 31.2 +/- 6.1 to 81.0 +/- 12.9 pM with ET-1. This increase was comparable after placebo and verapamil, but was 80% greater with ET-1 (P less than 0.02). Plasma ET-1, unchanged after placebo, rose (P less than 0.001) from 1.7 +/- 0.5 to 38.3 +/- 9.2 pM with ET-1. In the three experiments, heart rate and left atrial pressure (LAP) increased (P less than 0.001) similarly. The linear ...
Learn in-depth information on Atrial Natriuretic Peptide Blood Test, on why the laboratory test is performed, specimen collected, the significance of the results, and its use in diagnosing medical conditions.
Atrial natriuretic factor (ANF) is a hormone with the physiological characteristics of a regulator of body fluid volume. It is potent, has a short duration of action, and responds to a physiologically relevant stimulus in a negative feedback-controlled system. It can act directly or indirectly (via inhibition of aldosterone biosynthesis) on the kidney to alter sodium transport and may regulate fluid distribution within the extracellular space. The peptide circulates at low (nanomolar) levels, and recent studies with renal inner medullary cells document relevant receptor binding and second messenger activation in this concentration range. In vivo data support a direct action on the kidney to enhance natriuresis, and blockade of a primary catabolic pathway for ANF within the kidney results in augmented natriuresis at concurrent endogenous peptide concentrations. Long-term, low dose infusion directly into the renal artery of conscious dogs supports a physiological action of ANF to promote urinary ...
View Notes - Ch. 44 study guide from BIOL 50755 at University of Texas-Tyler. apparatus, angiotensin II, aldosterone, renin, atrial natriuretic factor. Knowledge goals: List an example of an
Background-The endocrine balance between atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system is critical for the maintenance of arterial blood pressure and volume homeostasis. This study investigated whether a cardiac imbalance between ANP and aldosterone, towards increased mineralcorticoid receptor (MR) signaling, contributes to adverse left ventricular (LV) remodeling in response to pressure overload. Methods and Results-We used the MR-selective antagonist eplerenone to test the role of MRs in mediating pressure overload-induced dilatative cardiomyopathy of mice with abolished local, cardiac ANP activity. In response to 21-days of transverse aortic constriction (TAC), mice with cardiomyocyte-restricted inactivation (KO) of the ANP receptor (guanylyl cyclase (GC)-A) or the downstream cGMP-dependent protein kinase I (cGKI) developed enhanced LV hypertrophy and fibrosis together with contractile dysfunction. Treatment with eplerenone (100 mg/kg/day) attenuated LV ...
Tonolo, G., Fraser, R., Connell, J. and Kenyon, C. (1988) Chronic Low-Dose Infusions of Dexamethasone in Rats - Effects on Blood-Pressure, Body-Weight and Plasma Atrial Natriuretic Peptide. Journal of Hypertension, 6(1), pp. 25-31 ...
Atrial natriuretic peptide (ANP), a hormone considered to be an important regulator of intravascular fluid volume, has been shown to bind specifically to receptors on endothelial cells. In this study, the role of ANP-specific binding was investigated by examining the effect of ANP on the morphology and macromolecular permeability of monolayer cultures of bovine aortic endothelial cells (BAEC). ANP alone (10-9 -10-6 M) had no observable effect on the morphology of the monolayers. However, incubation of the endothelial monolayers with ANP (10-8 -10-6 M) antagonized the characteristic thrombin-induced (1 unit/ml) cell shape changes and the formation of intercellular gaps. Since chemically and enzymatically generated oxidants have also been shown to alter endothelial cell shape and increase macromolecular permeability, the effect of ANP on oxidant-induced injuries was investigated. Treatment of endothelial monolayers with glucose oxidase (1.4 unit/ml) elicited changes in cell shape characterized by ...
Atrial natriuretic peptide (ANP) is a peptide hormone which reduces an expanded extracellular fluid (ECF) volume by increasing renal sodium excretion. ANP is synthesized, and secreted by cardiac muscle cells in the walls of the atria in the heart. These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood volume. ANP is one of a family of nine natriuretic peptides: seven are atrial in origin. ANP acts on the kidney to increase sodium and water excretion (natriuresis) in the following ways: 1) it dilates the glomerular afferent and constrict efferent arterioles, and relaxes the mesangial cells. This increases pressure in the glomerular capillaries, increasing the glomerular filtration rate (GFR), resulting in an increased amount of sodium and water being filtered and excreted. 2) It increases blood flow through the vasa recta, which washes the solutes sodium chloride (NaCl) and urea out of the medullary interstitium - the lower ...
In this urban, multiethnic, population-based sample, procalcitonin, a marker of bacterial infection, and MR-proANP, a marker for cardiac dysfunction, were each independently associated with 2 measures of subclinical cerebrovascular damage, SBI and WMHV. However, the association of MR-proANP concentrations with WMHV was less pronounced compared with the association with SBI.. Silent brain infarction serves as an imaging biomarker of vascular brain health. SBI has been associated with traditional vascular risk factors, as well as with future clinical stroke,20 cognitive decline, and dementia.3,21 The independent association of SBI with future stroke, however, after adjusting for vascular risk factors suggest that SBIs reflect either an overall effect of uncontrolled vascular risk factors better than the presence or absence of each individual factor or that other, yet unknown, factors play a role in the association with stroke and dementia. These unknown factors may include underlying chronic ...
It has been suggested that angiotensin converting enzyme (ACE) may play a role in the metabolism of atrial natriuretic peptide (ANP), and that ANP may interfere with angiotensin-induced vasoconstriction. This has been investigated within the forearm
Peptides , Natriuretic Peptides , Atrial Natriuretic Peptide (1-28), rat; SLRRSSCFGGRIDRIGAQSGLGCNSFRY (Disulfide bridge: 7-23); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: 7-23)
the myoendocrine cellsin the atria of the mammalian heart synthesize and secrete a hormone called atrial natriuretic peptide (ANP), which causes natriuresis and diuresis. Pharmacological studies in...
Angiotensin II (ANG II) and atrial natriuretic peptide (ANP) play important roles in the regulation of cardiovascular function and fluid balance (1,2). Circulating ANG II stimulates specific...
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British Atherosclerosis Society. Research Profile. Papers. Cockcroft JR, Ritter JM, Allison DJ, Causon R, Brown MJ. Localisation of extra adrenal catecholamine secreting tumours by selective venous sampling and nuclear magnetic resonance scanning. Postgrad Med J 1987;63:451-453.. Barrow SE, Cockcroft JR, Dollery CT, Hickling NE, Ritter JM. Identification of 13, 14-dihydro-15-oxo-prostaglandin F2 in the circulation during infusions of bradykinin and prostaglandin E2 in man. Br J Pharmacol 1987;81:245-250.. Webb DJ, Benjamin N, Allen MJ, Brown J, OFlynn M, Cockcroft JR. Vascular responses to local atrial natriuretic peptide infusion in man. Br J Clin Pharmacol 1988;26:245-251.. Benjamin N, Cockcroft JR, Collier J, Dollery CT, Ritter JM, Webb DJ. The effect of local converting enzyme inhibition on the vascular responses to angiotensin and bradykinin in the forearm resistance vessels in man. J Physiol 1989;412:543-555.. Cockcroft JR, Allen MJ, Benjamin N, Webb DJ. The effect of local angiotensin ...
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TY - JOUR. T1 - The albuminuric sction of atrial natriuretic peptide is not increased by hyperglycaemia. AU - Moore, KB. AU - McKenna, K. AU - McDonald, D. AU - Tormey, William. AU - Thompson, CJ. PY - 2002. Y1 - 2002. M3 - Article. VL - 51. SP - A516-A516. JO - Diabetes. JF - Diabetes. SN - 0012-1797. ER - ...
Distribution of human ANP32A transcripts in brain. Human MTE array was probed with a 750 bp human ANP32A radiolabeled probe as described under
In this issue of Diabetes, Miyashita et al. (1) provide compelling new evidence that natriuretic peptides (NPs) play a key role in the regulation of body weight and energy metabolism. In a series of complementary experiments, the investigators show that the NP-cyclic guanosine monophosphate (cGMP) signaling system increases the capacity for fat oxidation, activates mitochondrial biogenesis, and prevents the deleterious effects of a high-fat diet (HFD).. NPs are not new players in metabolic regulation. Since the discovery of atrial natriuretic peptide (ANP) in 1980 (2), a large body of work has highlighted the multifaceted roles of NPs in the regulation of blood volume and arterial pressure. NPs are members of a family of structurally similar but genetically distinct endogenous peptide hormones. The NP family consists of at least three mammalian peptides: atrial-, brain-, and C-type (ANP, BNP, and CNP, respectively) (3). ANP and BNP preferentially bind to a particulate guanylyl cyclase (GC) ...