Maastricht, The Netherlands, 25th October 2018 - Cristal Therapeutics, a clinical stage pharmaceutical company developing unique nanomedicines for the treatment of cancer and other diseases, announced today the first patient has been dosed in its Phase 2 clinical trial of lead nanomedicine candidate CPC634 for patients with platinum-resistant ovarian cancer. C. PC634 is a new drug modality. It combines CriPec® nanoparticles with docetaxel (Taxotere®), a clinically validated chemotherapy, as its therapeutic payload. This nanomedicine candidate has been designed to enable enhanced tumour accumulation and localised drug release at the target site, with the goal of boosting therapeutic efficacy. In addition, it is anticipated that CPC634 will overcome the shortfalls associated with current docetaxel products, including toxic systemic side effects.. Dr Joost Holthuis, Cristal Therapeutics CEO and co-founder said, Results from our Phase 1 NAPOLY study demonstrated that CPC634 can be administered ...

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1IJP: Structure of Ala(20) --> Pro/Pro(64) --> Ala substituted subunit c of Escherichia coli ATP synthase in which the essential proline is switched between transmembrane helices.

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Last year, the University of Waikato and NeSI collaborated on a masters paper to provide a practical hands-on introduction to using national-scale research facility such as NeSI. Cristal Bader, an honours student studying enzyme kinetics and using molecular dynamics at University of Waikato, was one of the first participants in that pilot paper. Building on the knowledge and skills she gained in the paper, Cristal was able to use NeSIs Mahuika supercomputer to computationally model the enzyme she was studying.. Participating in the paper enabled Cristal to use her computational research as part of her honours thesis, and has also equipped her with valuable skills to take forward into her research career. We asked Cristal to share some of the highlights of her experience taking the paper and accessing NeSI as a first-time user.. * * * * * * * * * * The University of Waikato ran a supercomputing paper for the first time this year, so I took it as part of my honours degree. The course took 12 ...

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ATP Synthase : First Look The following images attempt to illustrate how ATP synthase produces ATP and emphasize the key steps in this process. Clicking on each of the thumbnail images will bring up a larger, labeled version of the described scene.. To see the Flash movie for the following sequence of images, click here.. ...

MEMBUH: CONFESSIONS OF THE ONLY GENERATION (a staged essay about memory/memories-both imagined and real-of an African American past, present and future) Written/Directed by Cristal Chanelle Truscott Original Music by Maiesha McQueen When Lady, the oldest in a family of 20-somethings, becomes terminally ill, she gives her quirky relatives the task of recording their tumultuos family story in a time capsule for future generations. Combining […]

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ATP synthase link the phosphorylation of ADP to ETC during chemiosmosis,resulting in the production of ATP Impermeable to H+ to allow formation and maintenance of ...

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鈉鉀泵可以將細胞外相對細胞内較低濃度的鉀離子送進細胞，並將細胞内相對細胞外較低濃度的鈉離子送出細胞。經由以具放射性的鈉、鉀離子標定，可以發現鈉、鉀離子都會經過這個通道，鈉、鉀離子的濃度在細胞膜兩側也都是相互依賴的，所以顯示了鈉、鉀離子都可以經過這個載體運輸。目前已知鈉鉀泵需消耗ATP，並可以將三個鈉離子送出細胞，同時將兩個鉀離子送進細胞。 鈉鉀泵在1950年被丹麥的科學家延斯·斯科（Jens Skou）發現，它代表了我們對離子進出細胞的認識的一個重要的里程碑。它也在細胞刺激上有著重要的意義，像神經細胞的衝動，就是用鈉鉀泵幫助維持細胞電位使神經衝動得以傳輸。 ...

அடினோசின் முப்பொசுபேற்று அல்லது அடினோசின் முப்பாசுப்பேட்டு (Adenosine triphosphate (ATP)) என்பது அனைத்து உயிரினங்களின் கலங்களிலும் பயன்படுத்தப்படும் ஒரு முக்கியமான துணை நொதியமாகும். இது உயிரினங்களில் சக்திக்கான அளவீடாக உள்ளது. கலத்துக்கிடையில் அனுசேபத்துக்காக சக்தியை இடம் மாற்றும் முக்கியமான மூலக்கூறாக அடினோசின் முப்பொசுபேற்று விளங்குகின்றது. ஒளித்தொகுப்பு, காற்றுள்ள சுவாசம் ...

鈉鉀泵可以將細胞外相對細胞内較低濃度的鉀離子送進細胞，並將細胞内相對細胞外較低濃度的鈉離子送出細胞。經由以具放射性的鈉、鉀離子標定，可以發現鈉、鉀離子都會經過這個通道，鈉、鉀離子的濃度在細胞膜兩側也都是相互依賴的，所以顯示了鈉、鉀離子都可以經過這個載體運輸。目前已知鈉鉀泵需消耗ATP，並可以將三個鈉離子送出細胞，同時將兩個鉀離子送進細胞。 鈉鉀泵在1950年被丹麥的科學家延斯·斯科（Jens Skou）發現，它代表了我們對離子進出細胞的認識的一個重要的里程碑。它也在細胞刺激上有著重要的意義，像神經細胞的衝動，就是用鈉鉀泵幫助維持細胞電位使神經衝動得以傳輸。 ...

TY - JOUR. T1 - Light- and metabolism-related regulation of the chloroplast ATP synthase has distinct mechanisms and functions. AU - Kohzuma, Kaori. AU - Dal Bosco, Cristina. AU - Meurer, Jörg. AU - Kramer, David M.. PY - 2013/5/3. Y1 - 2013/5/3. N2 - The chloroplast CF0-CF1-ATP synthase (ATP synthase) is activated in the light and inactivated in the dark by thioredoxin-mediated redox modulation of a disulfide bridge on its γ subunit. The activity of the ATP synthase is also fine-tuned during steady-state photosynthesis in response to metabolic changes, e.g. altering CO2 levels to adjust the thylakoid proton gradient and thus the regulation of light harvesting and electron transfer. The mechanism of this fine-tuning is unknown. We test here the possibility that it also involves redox modulation. We found that modifying the Arabidopsis thaliana γ subunit by mutating three highly conserved acidic amino acids, D211V, E212L, and E226L, resulted in a mutant, termed mothra, in which ATP synthase ...

Ahmad Z. Identification of Phosphate Binding Residues in the Catalytic Sites of Escherichia coli ATP Synthase. Poster presented at 6th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; November 1, 2014.. Ahmad Z. Significance of α-subunit VISITDG Sequence Residues in the Catalytic Sites of Escherichia coli ATP Synthase. Poster presented at the FASEB Experimental Biology 2014 Conference; San Diego, CA; April 26-30, 2014. Abstract published in FASEB J. 2014 Apr;28(1): Supplement LB247.. Barrett KL [student], Kondrashov P, Kondrashova T, Clay IS [student], Johnson J. Image Recognition and Development of Hands-on Sonographic Skills by First-Year Kirksville College of Osteopathic Medicine Students as Assessed by Practical Ultrasound Skill Assessment Exam. Poster presented at the 3rd Annual Missouri Osteopathic Student and Post-graduate Research Symposium; Missouri Osteopathic Annual Convention; Branson, MO; April 30-May 4, 2014.. Baum KR [student], Pannu M [student], Choudhry ...

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1. In previous studies regulation of the F1F0-ATPase of mitochondrial complex V (ATP synthase) has been demonstrated in rat cardiomyocytes, canine mycocardium and skeletal muscle from children. The aim of the present study was to examine regulation of ATP synthase in human myocardium in response to different metabolic states.. 2. Biopsy material was obtained from 10 children undergoing cardiac surgery. Mitochondria in the post-nuclear supernatant were incubated under different metabolic conditions for 15 min and then broken by sonication. ATP synthase was measured spectrophotometrically using a coupled enzyme assay.. 3. ATP synthase can be rapidly measured in sonicated preparations of heart mitochondria from children. We show that direct regulation at the level of ATP synthase occurs in these mitochondria. ATP synthase capacity is decreased in response to blocking of the respiratory chain by cyanide (mimicking anoxia) or uncoupling of mitochondria, falling to 76% and 66% of control values ...

Read Genetics Mitochondrial ATP Synthase Proteins by Homework Help Classof1 with Rakuten Kobo. The mitochondrial ATP synthase is composed of multiple proteins, and some of these proteins are encoded by genes in the...

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.

Les proteïnes HMG (High Mobility Group) són un grup de proteïnes cromosòmiques no histones que van ser anomenades així degut a la seva mobilitat electroforètica. Aquest conjunt de proteïnes està dividit en tres grans subfamílies: les HMGA, les HMGB i les HMGN. Les proteïnes HMGA poden modificar la conformació espacial del DNA, regulant (positivament o negativament) lexpressió de nombrosos gens i influint en molts processos cel·lulars normals com ara el creixement, proliferació, diferenciació i mort cel·lular, i la reparació del DNA. També estan relacionades amb diferents processos patològics, entre ells lobesitat, la diabetis, larteriosclerosi i el càncer. Sha observat com, en molts tipus de càncers, hi ha una sobre-expressió daquestes proteïnes. Se sap que la interacció HMGA-DNA es dóna a través duns motius dunió al DNA anomenats AT-hooks, els quals suneixen a regions riques en adenines (A) i timines (T) del DNA. En les proteïnes HMGA es troben tres motius ...

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ATP, which stands for adenosine triphosphate, is the sole source of energy for all human metabolism, yet very little of this fuel is actually stored in the body. ANSWER:Electrons gain energy as they move down the chain. When ADP and Pi are bound to ATP synthetase, the excess of protons (H+) that has formed outside of the mitochondria (an H+ gradient) moves back into the mitochondrion through the enzyme complex. In the first, intermediate compounds of the central routes of metabolism are diverted from further catabolism and are channeled into pathways that usually lead to the formation of the relatively small molecules that serve as the building blocks, or precursors, of macromolecules. Passage of protons (H+) through it from inside to outside generates ATP. Which energy system produces ATP at the slowest rate? Krebs Cycle (Citric Acid Cycle or Tricarboxylic Acid Cycle) In the presence of oxygen, pyruvate enters … Most of the ATP in cells is produced by the enzyme ATP synthase, which converts ...

The reboot follows two of Americas wealthiest families, the Carringtons and the Colbys, as they feud for control over their fortune and their children focusing on Fallon Carrington, the daughter of billionaire Blake Carrington, and her soon-to-be stepmother, Cristal, a Hispanic woman marrying into this WASP family and Americas most powerful class.. ...

Cristal Therapeutics is a clinical stage biopharma company developing the next generation nanomedicines based on its proprietary CriPec platform to treat various diseases, including cancer.. ...

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ATP5C1 (ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.

A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.

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TY - JOUR. T1 - Predictive validity of the CriSTAL tool for short-term mortality in older people presenting at Emergency Departments: a prospective study. AU - Cardona, Magnolia. AU - Lewis, Ebony. AU - Kristensen, Mette R.. AU - Skjøt-Arkil, Helene. AU - Ekmann, Anette A.. AU - Nygaard, Hanne H.. AU - Turner, Robin M.. AU - Garden, Frances. AU - Alkhouri, Hatem. AU - Asha, Stephen Edward. AU - Mackenzie, John. AU - Perkins, Margaret. AU - Suri, Sam. AU - Holdgate, Anna. AU - Winoto, Luis. AU - Chang, David C. W.. AU - Luxan, Blanca Gallego. AU - McCarthy, Sally. AU - Petersen, John A.. AU - Jensen, Birgitte N.. AU - Mogensen, Christian Backer. AU - Hillman, Ken. AU - Brabrand, Mikkel. PY - 2018/12/1. Y1 - 2018/12/1. N2 - PurposeTo determine the validity of the Australian clinical prediction tool Criteria for Screening and Triaging to Appropriate aLternative care (CRISTAL) based on objective clinical criteria to accurately identify risk of death within 3 months of admission among older ...

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Adenosine triphosphate (ATP), the chemical energy currency of biology, is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic mechanism where proton translocation through the membrane-inserted FO region is coupled to ATP synthesis in the catalytic F1 region via rotation of a central rotor subcomplex. We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining cryo-EM data with bioinformatic analysis allowed us to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits. 3D classification of images revealed seven distinct states of the enzyme that show different modes of bending and twisting in the intact ATP synthase. Rotational fluctuations of the c8-ring within the FO region support a Brownian ratchet mechanism for proton-translocation-driven rotation in ATP synthases.. ...

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These Bic Cristal Ballpoint Pens feature a durable tungsten carbide ball mechanism and smooth oil-based ink for reliable, everyday use. The medium 1.0mm tip produces a thin 0.4mm line for elegant handwriting and detailed sketching. The hexagonal barrel includes a blue cap and end plug that matches the ink for easy identification. This pack contains 50 blue pens.

The human ATP5C1 gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes adenosine triphosphate(ATP) synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. GRCh38: Ensembl ...

Looking for ATP synthase? Find out information about ATP synthase. An enzyme that catalyzes the conversion of phosphate and adenosine diphosphate into adenosine triphosphate during oxidative phosphorylation in mitochondria... Explanation of ATP synthase

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Jean NoIl Joffin writes: ,I am looking for a small information. Too stains can be used for Gram staining :cristal violet (violet cristal) and gentian violet. I think these two stains are the same. Is it true ?, Yes and no. Gentian violet is the impure form of crystal violet. --Yersinia ...

ETC: Advanced Look --, 4.) ATP Synthase ATP synthase is considered a part of the electron transport chain, but it is not involved in the transport of electrons. ATP synthase uses the proton gradient created by the ETC to synthesize ATP. Clicking on each of the thumbnail images will bring up a larger, labeled version of the described scene.. To see the Flash movie for the following sequence of images, click here.. ...

Despite its limited resolution, this structural model is squarely consistent with the two-half-channel hypothesis outlined above and also helps to rationalize a wide range of biochemical data pertaining to the mechanism and inhibition of the enzyme. By construction, the structure shows one of the proton-binding sites in the c-ring in proximity to both Arg145, the crucial arginine in TM4 of subunit a, and Gln201 in TM5 (Fig. 6 A). The Cα-Cα distance from Glu58 to Arg145 (8 Å) is indeed consistent with a salt bridge, and that to Gln201 (13 Å) implies this same interaction would be feasible if Arg145 and Gln201 were swapped, as has been suggested for the E. coli ATP synthase (Ishmukhametov et al., 2008; Bae and Vik, 2009). A nontrivial finding, however, is that this c-ring binding site is aligned with a series of residues on subunit a that have been inferred to be exposed to the aqueous half-channel on the P side of the membrane (Fig. 6 A). Specifically, these are positions whose equivalent in ...

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1 VASE CLEAR CUT CRISTAL. CRYSTAL GLASS ART From FRANCE. All items will be securely packed, individually wrapped with acid-free silk paper, foam, bubble wrap and reinforced cardboard. Les pièces seront soigneusement emballées individuellement et protégées avec du film bulle et carton renforcé. Pour les pays autres que la France, envoi en recommandé avec assurance Ad Valorem à hauteur de la valeur de lobjet. Unless specified otherwise in the description, all our items are previously owned. There will be logical traces of usage, consistent with age and normal use. Please take note of this and ask any other information if you have further enquiries. We describe our items the best we can with pictures reflecting the condition as closely as possible.. Other pictures are available on demand. MERCI DE POSEZ TOUTES VOS QUESTION AVANT DENCHERIR OU DACHETER. A moins que ce soit spécifié autrement dans la description, nos objets en vente sont doccasion. Par conséquent des traces dusage existent ...

brass - o latão | cement - o cimento | ceramic - a cerâmica | cloth - o pano | cloth - o tecido | cotton - o algodão | crystal - o cristal | dirt - a sujeira | glue - a cola | leather - o couro | metal - o metal | oil - o óleo | powder - o pó | salt - o sal | sand - a areia | scrap - a sucata | silver - a prata | stone - a pedra | straw - a palha | wood - a madeira | wool - a lã |

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Dario Teixeira wrote: , Hi, , , Suppose I have a value of type Story.t, fairly complex in its definition. , I wish to store this value in a DB (like Postgresql) for posterity. , At the moment, I am storing in the DB the marshalled representation , of the data; whenever I need to use it again in the Ocaml programme , I simply fetch it from the DB and unmarshal it. , , This works fine; there is however one nagging problem: the marshalled , representation is brittle. If Story.t changes even slightly, I will , no longer be able to retrieve values marshalled with the old version. It is even theoretically a very difficult problem. There have been some publications by Cristal, Moscova, Gallium people at INRIA. Assuming you have no abstract types, no objects, and no closures, and no polymorphisms i.e. that there is a *.ml source file containing all the type definitions. Then the types are composed by base types (int, string, ...), sums, records, and perhaps arrays. Then you could consider what are the ...

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Well, I think I dont need to take a look at my christal ball to be able to see that you are going to be stiff all over soon. Well at least the arms. And face. The book is going to be such a hit and you will have to stand for so much photos… You have to stard training right now or smiling will get hard. ;-). My best wishes from Spain. Im sure the book will be a SUPER HIT. And you will be great in photos (arm up or not). Hey, Im thinking… Maybe you are creating a new way of posing, in saome weeks this could be trendy. ;-). I hope I didnt write anything wrong, my english is not good enough for this. Just in case, I write it also in spanish, just in case someone can translate it to you.. Querida Bakerella. Creo que no necesito sacar mi bola de cristal para poder decirte que pronto vas a tener unas agujetas tremendas. Por lo menos en los brazos. Y tal vez en la cara. El libro va a ser un éxito tan tremendo y te van a hacer tantas fotos… que vas a tener que empezar a entrenar ya o te ...

Well, I think I dont need to take a look at my christal ball to be able to see that you are going to be stiff all over soon. Well at least the arms. And face. The book is going to be such a hit and you will have to stand for so much photos… You have to stard training right now or smiling will get hard. ;-). My best wishes from Spain. Im sure the book will be a SUPER HIT. And you will be great in photos (arm up or not). Hey, Im thinking… Maybe you are creating a new way of posing, in saome weeks this could be trendy. ;-). I hope I didnt write anything wrong, my english is not good enough for this. Just in case, I write it also in spanish, just in case someone can translate it to you.. Querida Bakerella. Creo que no necesito sacar mi bola de cristal para poder decirte que pronto vas a tener unas agujetas tremendas. Por lo menos en los brazos. Y tal vez en la cara. El libro va a ser un éxito tan tremendo y te van a hacer tantas fotos… que vas a tener que empezar a entrenar ya o te ...

RÉSISTANCE AU MOMENT DE TORSION 】: Cet ensemble de clés à douille. Design de sensation spéciale de clavier mécanique clavier. pompes à eau ; machine de soudage et d'autres équipements comme un élément d'amortissement, Amélioration de léquilibre de lobjectif monté sur trépied. the picture may not reflect the actual color of the item. Poids : environ 150 grammes chacun, utilisation: décor, Lanterne pour lextérieur, Mais les séparateurs de tiroir Hossejoy peuvent facilement résoudre ce problème. Elément de format: Fixé. Veuillez lencadrer par des lunettes ou du bois et accrocher dans votre maison pour les ornements décoratifs, Mais si vous souhaitez une taille plus confortable, Forme du contact: SPDT NO + NC. Transient current:9a-10a, Livré dans un coffret cadeau gratuit aussi, McKinley Hommes Bottes Dhiver Luca AQX Grey Dark. souris et câbles, Conçus et fabriqués en Italie dans notre usine depuis 1908, Empire français moderne Chrome Fini Cristal Semi ...

filtered_set; syntelog; UniRef90: B6T754_MAIZE ATP12 ATPase n=3 (Andropogoneae) Exp=2e-145; maizesequence.org: Uniprot/SPTREMBL:B6TXI2; ATP12 ATPase , Uniprot/SPTREMBL:B6T754; ATP12 ATPase , UniGene:Zm.76376; LOC100282414 , UniGene:Zm.145495; TSA: Zea mays contig46830 mRNA sequence , UniGene:Zm.128987; Hypothetical protein LOC100193204 , RefSeq_peptide:NP_001148797; LOC100282414 , RefSeq_dna:NM_001155325; LOC100282414 (IDP705) mRNA , GO:0043461; proton-transporting ATP synthase complex assembly , GO:0005515; protein binding , EntrezGene:100282414; ...

Construction of a first atomic model for an intact bacterial ATP synthase allows for a structural understanding of the roles of individual amino acids in the mechanism of ATP synthesis.

[1] Hong, S. and Pedersen, P.L. (2008) ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas. Microbiology Molecular Biology Reviews, 72, 590-641.doi10.1128/MMBR.00016-08

O-Desmethyl N-Desmethyl Venlafaxine ;. N-Desmethyl Desvenlafaxine ;. N,O-Didesmethyl Venlafaxine ;. 4-[2-(Methylamino)-1-(1-hydroxycyclohexyl) ethyl]phenol ;. CAS # 135308-74-6 ;. C15H23NO2 ;. MW: 249.35 ;. ...

Nizatidine N-Desmethyl Metabolite ;. N-Desmethyl Nizatidine ;. N2-Monodesmethyl Nizatadine ;. N-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-2-nitro-1,1-ethenediamine ;. CAS # 82586-78-5 ;. C11H19N5O2S2 ;. MW: 317.43 ;. ...

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Influential bioenergetics and enzyme kinetics researcher Harvey S. Penefsky passed away in July at the age of 92. Penefskys kinetic insights shaped the understanding of the mechanism of ATP synthase. This research provided the groundwork for Paul D. Boyer, who elucidated the enzymatic mechanism of ATP synthase. ...

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ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c3 (subunit 9) genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-020814-1 ...

目的：探讨甲状腺微小癌（TMC）的临床特点、诊断及手术方式。方法：回顾性分析2011年1月-2014年6月间经手术及病理证实262例TMC患者的临床资料，并选取90例同期手术治疗的甲状腺良性甲状腺结节（BTN）患者的资料进行对比分析。结果：262例TMC患者中，乳头状癌260例，滤泡状癌1例，未分化癌1例；术中冷冻切片确诊246例（93.9%）；合并结节性甲状腺肿126例（48.09%），甲状腺腺瘤18例（6.87%），慢性淋巴细胞性甲状腺炎27例（10.30%），甲状腺功能亢进3例（1.15%）。与BTN患者比较，TMC患者超声显示低回声、沙砾样钙化、血流信号丰富、高TI-RADS分级的比率明显高于BTN组（均P|0.05）；高分辨超声对TMC诊断的灵敏度、特异度、阳性预测值、阴性预测值分别为83.88%、80.50%、91.73%、65.97%。所有患者均行手术治疗，包括患侧腺叶+峡部切除术73例，患侧腺叶+峡部+对侧次全切除术153例

What is Peak ATP? What does it do and how does it work? What is the preferred dosage? Are there any good studies in humans to support it?