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The antihypertensive effect of atenolol, with and without chlorthalidone, on hypertension was assessed in an outpatient as well as in an inpatient study. In the outpatient study atenolol alone induced decreases in systolic and diastolic BP amounting to 20 and 15 mm Hg. Maximal response of BP and HR developed within a week at the lowest dose used (100 mg twice daily). Combined atenolol-chlorthalidone treatment decreased lying and standing systolic BP by 7 and 14 mm Hg more than atenolol alone, but diastolic BP was decreased little more. In the inpatient study the addition of atenolol to chlorthalidone therapy in a dose of 100 mg twice daily resulted in a maximal decrease in BP within 3 days. At this dose PRA was lowered only slightly. Larger doses did not lead to any significant further decrease in BP, whereas PRA fell progressively. Our results indicate that, in contrast to nonselective blockade, specific beta-1-adrenoceptor blockade by atenolol is capable of inducing a distinct antihypertensive effect,
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Source: American Journal of Therapeutics. 1997 April; 4(4): 117-22. cmd=Retrieve&db=PubMed&list_ uids=10423600&dopt=Abstract • Quality of life before and during antihypertensive treatment: a comparative study of celiprolol and atenolol. Author(s): Cleophas TJ, van der Mey N, van der Meulen J, Niemeyer MG. Source: Int J Clin Pharmacol Ther. 1996 July; 34(7): 312-7. cmd=Retrieve&db=PubMed&list_ uids=8832309&dopt=Abstract • Quality of life in hypertensives treated with atenolol or captopril: a double-blind crossover trial. Source: Cardiology. 2001; 96(2): 65-71. cmd=Retrieve&db=PubMed&list_ uids=11740134&dopt=Abstract • Different effects of fosinopril and atenolol on wave reflections in hypertensive patients. Author(s): Chen CH, Ting CT, Lin SJ, Hsu TL, Yin FC, Siu CO, Chou P, Wang SP, Chang MS. Source: Hypertension. 1995 May; 25(5): 1034-41. cmd=Retrieve&db=PubMed&list_ uids=7737712&dopt=Abstract Studies 25 • Different hemodynamic effects of celipropol and atenolol in patients with mild to ...
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Atenolol is a beta-blocker. Chlorthalidone is a thiazide diuretic (water pill). Atenolol and chlorthalidone is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Atenolol and chlorthalidone may also be used for purposes not...
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Atenolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Atenolol and chlorthalidone is a combination medicine used to...
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A 57-year-old man (b.w. 75 kg), two previous myocardial infarctions and major depressive disorders, was admitted to the emergency room about 1 hour after suicidal ingestion of 2800 mg atenolol and 1600 mg verapamil. The patient was pale, cold, comatose and showed respiratory insufficiency which needed intubation and mechanical ventilation. Hemodynamic monitoring was started, including heart rate (HR), invasive blood pressure (BP) measurement, pulmonary artery pressures and cardiac output (CO). Despite aggressive inotropic therapy with dopamine 30 µg/kg/min, adrenaline 10 µg/kg/min and calcium chloride (4 g total), clinical conditions progressively worsened: BP was 80/60 mmHg, HR was 65 bpm, CO 1.4 l/min, SVR 3371 dyne/s/cm-5, central venous pressure (CVP) 16 mmHg and PCWP 18 cmH2O; urine output dropped to zero.. Four hours after ingestion, a bolus dose of enoximone 1 mg/kg was administered, followed by a continuous infusion at 0.5 mg/kg/h. During the following hours the patients clinical ...
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The study was conducted to find out the effects of atenolol on blood lipid profile of common rabbits (Oryctolagus cuniculus). The administration of an oral dose of 0.6 mg atenolol kg-1 day-1 for 27 days produced a strong dyslipidemia, which was evident by a significant (p,0.05) reduction in mean plasma cholesterol and triglycerides levels, a marked alteration in mean HDL-cholesterol concentration and a non-significant elevated level of LDL-cholesterol. These findings suggest that atenolol is an inappropriate antihypertensive monotherapic agent for patients suffering with the abnormalities of lipid metabolism ...
In the ASCOT study, we report that amlodipine-based treatment decreased NT-proBNP ,6 months, whereas atenolol-based treatment increased it. Among the amlodipine-based treatment group, an achieved NT-proBNP below the median was associated with a lower risk of subsequent CVD events. These observations are notable given that the amlodipine-based treatment randomized arm had fewer total cardiovascular events than the atenolol-based treatment randomized arm (hazard ratio, 0.84; 95% confidence interval, 0.78-0.90; P,0.0001).15. In line with a growing body of evidence,4-6 baseline NT-proBNP enhanced prediction of CVD events among hypertensive men and women without prior CVD. Thus, NT-proBNP may be a useful biomarker in the context of risk prediction in people with hypertension. Data from a small cohort study of patients with hypertension (median NT-proBNP of 82 pg/mL; highly comparable with our cohort) previously reported that NT-proBNP is associated with mortality (n=40 outcomes) independent of a ...
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LEWIS, R, MACLEAN, D, IOANNIDES, C, JOHNSTON, A and MCDEVITT, DG (1988) A COMPARISON OF BISOPROLOL AND ATENOLOL IN THE TREATMENT OF MILD TO MODERATE HYPERTENSION ...
HbA(1c) and other parameters of short- and long-term glycemic control were in a more favorable range after antihypertensive treatment with verapamil SR plus trandolapril as compared with atenolol plus chlorthalidone.
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Tenoric (Atenolol/Chlorthalidone) is an oral beta-blocker prescribed to treat patients suffering from hypertension, angina, or arrhythmias.
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