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The efficacy and effect on cardiac function of verapamil 120 mg three times a day and atenolol 100 mg once a day, singly and in combination, were evaluated in 15 patients with angina pectoris. While they were on the combination treatment four patients withdrew from the study. Episodes of angina pectoris and glyceryl trinitrate consumption were significantly reduced only on the combination. On the combination only four patients developed evidence of ischaemia during exercise compared with seven on verapamil and ten on atenolol. ST segment depression at peak exercise, assessed by 16 point precordial mapping, was reduced by all active treatments from 7.1 on placebo to 2.7, 0.9, and 0.6 mm on atenolol, verapamil, and the combination respectively. Mean left ventricular ejection fraction fell significantly from 60% on placebo to 53% on the combination but was unchanged on verapamil and atenolol. Verapamil was an effective alternative to atenolol; the combination was the most effective treatment but ...
The aim of this study was to evaluate changes in cerebral hemodynamics in young patients with uncomplicated hypertension before and after effective antihypertensive treatment with a beta-blocker drug. Changes in mean flow velocity in the middle cerebral artery from normal condition to hypercapnia were evaluated by means of a transcranial Doppler in 42 hypertensive patients and 21 healthy subjects comparable for age and sex distribution. We obtained hypercapnia with breath-holding and evaluated cerebrovascular reactivity with the breath-holding index (BHI). After a baseline evaluation (time 0), patients were randomly assigned to a placebo (group 1) or atenolol (group 2) therapy. The evaluation was repeated after 30 (time 1) and 60 (time 2) days of treatment. Before treatment, hypertensive patients had significantly lower BHI values (0.96 +/- 0.1 group 1 and 0.85 +/- 0.3 group 2) than controls (1.69 +/- 0.4) (P , 0.0001). During treatment, mean blood pressure significantly decreased in group 2 ...
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TY - JOUR. T1 - Hemodynamic effects of the antihypertensive treatment with atenolol plus chlortalidone in fixed combination. T2 - A double-blind crossover comparison with atenolol. AU - Ricciardelli, B.. AU - Cuocolo, A.. AU - De Luca, N.. PY - 1985. Y1 - 1985. N2 - Twenty patients with mild or moderate essential hypertension participated in a double-blind crossover randomized trial aimed at assessing, by echocardiography, the hemodynamic effects of the antihypertensive therapy with atenolol administered once daily (100 mg) alone or combined with chlortalidone (25 mg) in fixed combination. Blood pressure and heart rate were measured at rest and during bicycle exercise before and after four-week periods of treatment. Both atenolol and atenolol plus chlortalidone reduced significantly blood pressure and heart rate. The reduction in blood pressure was mediated by a reduction in cardiac output. However, the combined treatment was also able to prevent the increase in stroke volume observed after ...
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In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol has been demonstrated by: (1) reduction in resting and exercise heart rate and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia, and (4) reduction in reflex orthostatic tachycardia.. A significant beta-blocking effect of atenolol, as measured by reduction of exercise tachycardia, is apparent within one hour following oral administration of a single dose. This effect is maximal at about 2 to 4 hours, and persists for at least 24 hours. Maximum reduction in exercise tachycardia occurs within 5 minutes of an intravenous dose. For both orally and intravenously administered drug, the duration of action is dose related and also bears a linear relationship to the logarithm of plasma atenolol concentration. The effect on exercise tachycardia of a single 10 mg intravenous dose is largely dissipated by 12 ...
In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol has been demonstrated by: (1) reduction in resting and exercise heart rate and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia, and (4) reduction in reflex orthostatic tachycardia.. A significant beta-blocking effect of atenolol, as measured by reduction of exercise tachycardia, is apparent within one hour following oral administration of a single dose. This effect is maximal at about 2 to 4 hours, and persists for at least 24 hours. Maximum reduction in exercise tachycardia occurs within 5 minutes of an intravenous dose. For both orally and intravenously administered drug, the duration of action is dose related and also bears a linear relationship to the logarithm of plasma atenolol concentration. The effect on exercise tachycardia of a single 10 mg intravenous dose is largely dissipated by 12 ...
In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol has been demonstrated by: (1) reduction in resting and exercise heart rates and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia and (4) reduction in reflex orthostatic tachycardia. A significant beta-blocking effect of atenolol, as measured by reduction of exercise tachycardia, is apparent within one hour following oral administration of a single dose. This effect is maximal at about 2 to 4 hours and persists for at least 24 hours. The effect at 24 hours is dose related and also bears a linear relationship to the logarithm of plasma atenolol concentration. However, as has been shown for all beta blocking agents, the antihypertensive effect does not appear to be related to plasma level. In normal subjects, the beta1 -selectivity of atenolol has been shown by its reduced ability to reverse the ...
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TY - JOUR. T1 - Modification of cellular immune functions in humans by endurance exercise training during β-adrenergic blockade with atenolol or propranolol. AU - Watson, Ronald R. AU - Moriguchi, S.. AU - Jackson, J. C.. AU - Werner, L.. AU - Wilmore, J. H.. AU - Freund, B. J.. PY - 1986. Y1 - 1986. N2 - Young, healthy, previously inactive men were trained aerobically 40 to 50 min·d-1, 5 d·wk-1 for 15 wk. They were randomly assigned to one of three medication groups: placebo, propranolol (160 mg·d-1), or atenolol (100 mg·d-1). All subjects lost weight and decreased relative body fat as a result of training. Following training, submaximal steady-state heart rates were reduced in all groups. Maximal oxygen uptake and maximal treadmill times were also increased in all groups. The V̇O(2max) of the placebo increased 18.4%. While that of the atenolol group increased 19.4%, the propranolol group went up 17.0%. After training the maximal heart rate did not change in the placebo group, while ...
Eighteen male patients (aged 40-66 years) with confirmed ischaemic heart disease and a minimum of four angina attacks per week were included in a double-blind comparison of dilevalol 200 mg, dilevalol 400 mg and atenolol 100 mg. Following a one-week placebo run-in period patients were randomly allocated to one of the three treatments, after which they crossed to the remaining two treatments according to a balanced Latin square design. Each treatment was given once-daily over four weeks. Symptom-limited treadmill exercise testing using a modified Bruce protocol was performed at the end of placebo, and after each treatment around 24 hours post-dosing. The mean exercise time on placebo was 7.0 (+/- 0.91) minutes which changed to 7.8 (+/- 0.93) minutes on dilevalol 200 mg, 7.3 (+/- 0.88) minutes on dilevalol 400 mg and 8.2 minutes (+/- 1.06) on atenolol 100 mg. Nine patients had a greater exercise tolerance on dilevalol (200 or 400 mg), and nine a greater exercise tolerance on atenolol. Maximum exercise
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I am new in this forum. I delivered my daughter in Mar 01 at 28 weeks(weighed 2 lbs and 11 oz) due to very severe PE. I wasnt being monitered at all and my BP went very high where they did the c-section just hours after i got admittted for 24 hr protien checkup. I am currently 10 weeks 5 day preg.My bp is 132/88 on an average and my pulse is normally between 95 and 100. I was taking Aldomet 250 x 2 a day. I am already starting to spill a mild amount of protien in the urine. I just met my perinatologist here is seattle yesterday and said i need to go on Atenolol and baby aspirin, extra folic acid to reduce the pulse rate and lower the bp too ...
I am new in this forum. I delivered my daughter in Mar 01 at 28 weeks(weighed 2 lbs and 11 oz) due to very severe PE. I wasnt being monitered at all and my BP went very high where they did the c-section just hours after i got admittted for 24 hr protien checkup. I am currently 10 weeks 5 day preg.My bp is 132/88 on an average and my pulse is normally between 95 and 100. I was taking Aldomet 250 x 2 a day. I am already starting to spill a mild amount of protien in the urine. I just met my perinatologist here is seattle yesterday and said i need to go on Atenolol and baby aspirin, extra folic acid to reduce the pulse rate and lower the bp too ...
Atenolol Tablet 50mg should be taken once a twice a day by mouth and with or without food as directed by your healthcare provider. Avoid drinking apple or orange juice within four hours of taking atenolol because these juices prevent your body from fully absorbing Atenolol.. The dosage that your doctor prescribes to you will be based on your medical condition and in response to your treatment. Remember to continue taking this medication even on the days when you feel well so that it can have a proper, well-rounded effect. It may take up to one or two weeks for you to get the full benefit of this medication. However, if your condition does not improve, or if it worsens, after a week of taking the medication, consult your doctor.. ...
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Hemodynamic (systemic and regional), metabolic and cardiovascular reflexive variables were measured before and after 4 weeks of beta blockade with atenolol in 10 patients with mild essential hypertension. Atenolol reduced mean arterial pressure, heart rate, cardiac index (all p less than 0.005) and renal vascular resistance (p less than 0.01) and increased total peripheral resistance (p less than 0.005). Glomerular filtration rate and renal blood flow were unchanged; plasma renin activity fell 43%. Reflexive cardioacceleration during the Valsalva maneuver and upright passive tilt was blunted. No changes were observed in circulating fluid volumes. In six patients followed for 1 year, blood pressure and heart rate were maintained at levels similar to those during the first 4 weeks. Atenolol was shown to be an effective oral antihypertensive that has no apparent deleterious hemodynamic effects on the renal and splanchnic circulations. ...
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