The prevalence of the recently identified astrovirus MLB1 in a cohort of children with diarrhea in St. Louis, Missouri, USA, was defined by reverse transcription-PCR. Of 254 stool specimens collected in 2008, 4 were positive for astrovirus MLB1. These results show that astrovirus MLB1 is circulating in North America.
MLB: The Net Result | A popular tout service selection is to recommend laying the run line with elite teams. Take a couple of losses following such a
Every MLB team enters the offseason with multiple needs. Theres no such thing as a squad with only one item on its winter shopping list, and that includes the legitimate World Series hopefuls...
Can you name the 2012 MLB Second Basemen and Shortstops? Test your knowledge on this sports quiz to see how you do and compare your score to others. Quiz by sanchize37
Can you name the MLB 2009 Team by Player (Normal)? Test your knowledge on this sports quiz to see how you do and compare your score to others. Quiz by Blaise
Newsday reporter Gus Garcia-Roberts, responsible for breaking and covering the 2013 biogenesis scandal, says new MLB commissioner Rob Manfred leads all professional sports in effective PED findings and suspensions.
Waiver Wired: This Weeks Top MLB Pickups. D.J. Short takes a look at this weeks top waiver wire pickups in AL, NL and Mixed leagues.
The 2017 MLB season has been dominated by offense, but that doesnt mean there havent been great pitching performances. While the usual suspects like Clayton Kershaw, Max Scherzer, Chris Sale and Corey Kluber have all been unsurprisingly...
Barry M. Bloom has been a national reporter for MLB.com since 2002 and has more than 35 years of experience covering sports.
Barry M. Bloom has been a national reporter for MLB.com since 2002 and has more than 35 years of experience covering sports.
Greetings! Welcome to the Second Weekly Edition of my Greatest Players in MLB according to their respective positions. Lets dive right into this weeks edition - Third Baseman. 10) Jimmy Collins...
MLB Report Date is different for every Club and Position. Luckily, you are going to report early and voluntarily. February 16 or Feb 28 are different.
A new number one this week, the Rangers prove to be leaders as they are on a four-game winning streak. The Red Sox fell behind and are now seventh in the rankings. - Mare McKeever
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HOUSTON -- The All-Star break offers different things for different players. For some, its a chance to rest and reset before the second half of the season begins.
7/24/11: Bartolo Colon limits the As to two runs on eight hits over eight strong innings, recording four strikeouts en route to the win
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2011 對台灣的棒球迷們而言3是個幸福的一年3MLB全明星賽首次來台舉行3就連停辦兩年的亞洲職棒大賽3亦由台灣接手舉辦3雖然統一獅最後的成績差強人意3但還是給了我美好的一年》在職棒22年全部比賽結束後3統一獅依序在台北及高雄舉行兩場的全隊簽名會》可惜十月底在阪急台北店的那場總冠軍球迷會3不巧和高美濕地馬拉松撞期3只好放棄3而這場在夢時代的簽名會3又正好和 屏東單車國道馬拉松 同一天3此等大好良機就不能錯過啦!先在此感謝 PTT 統一獅版的一位熱心版友3在官方購物商城慶祝封王的期間3以會員VIP可享七折的優惠3幫我代購了兩顆空白大球3及一顆陳鏞基背號的空白球》 ...
To the Editor: Human astroviruses (HAstVs), first identified in 1975, are now considered an important cause of viral gastroenteritis, predominately infecting children ,2 years of age (1,2). HAstVs are classified into 8 serotypes. A unique astrovirus, MLB1 (AstV-MLB1), recently was discovered in a fecal sample from a child with diarrhea in Australia (3); subsequently, at least 6 novel astroviruses have been discovered from fecal samples, including AstV-MLB2, AstV-MLB3, HMO AstV-A/VA2, HMO AstV-C/VA1, HMO AstV-B/VA3, and AstV-VA4 (4-7). The prevalence of novel astroviruses in China remains unclear.. Fecal specimens were collected during July 2010-June 2011 from 723 children ,5 years of age who had acute gastroenteritis. Samples were from all of 295 eligible children brought for care to First Hospital of Lanzhou University (Lanzhou, China) and every fifth eligible child (n = 428) brought for care on 2 days of the week (Tuesday and Thursday) at Nanjing Childrens Hospital (Nanjing, China). The ...
Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease.
Infectious diarrhea leads to significant mortality in children, with 40 % of these deaths occurring in Africa. Classic human astroviruses are a well-established etiology of diarrhea. In recent years, seven novel astroviruses have been discovered (MLB1, MLB2, MLB3, VA1/HMO-C, VA2/HMO-B, VA3/HMO-A, VA4); however, there have been few studies on their prevalence or potential association with diarrhea. To investigate the prevalence and diversity of these classic and recently described astroviruses in a pediatric population, a case-control study was performed. Nine hundred and forty nine stools were previously collected from cases of moderate-to-severe diarrhea and matched controls of patients less than 5 years of age in Kenya and The Gambia. RT-PCR screening was performed using pan-astrovirus primers. Astroviruses were present in 9.9 % of all stool samples. MLB3 was the most common astrovirus with a prevalence of 2.6 %. Two subtypes of MLB3 were detected that varied based on location in Africa. In this case
There have been some evidence that there are distinct subtypes of turkey astrovirus. Strain et.al., performed experiment in differentiating the types of turkey astrovirus. Predicted capsid amino acid sequences were first used to assessed the relationship of the novel clinical TAstV isolates within the Astroviridae 6. The TAstV-1 capsid sequence was found in a clade containing avian nephritis virus, with distance between it and the TAstV-1. Sequence analysis of TastV-1 and TastV-2 diagnostic amplicons was used to demonstrate that the levels of variation among TastV-1 and TastV-2 are very diverse. The phylogenetic analysis of the full-length capsid genes of both types of Tast-V shows that both may have originated from separate introductions into the turkey species and that there are at least two lineages which are distinct subtypes instead of serotypes. There are potential serotypes to appear within each subtypes. A computer analysis was done by Jonassesen et.al. that focused on the ORF1a gene ...
There have been some evidence that there are distinct subtypes of turkey astrovirus. Strain et.al., performed experiment in differentiating the types of turkey astrovirus. Predicted capsid amino acid sequences were first used to assessed the relationship of the novel clinical TAstV isolates within the Astroviridae 6. The TAstV-1 capsid sequence was found in a clade containing avian nephritis virus, with distance between it and the TAstV-1. Sequence analysis of TastV-1 and TastV-2 diagnostic amplicons was used to demonstrate that the levels of variation among TastV-1 and TastV-2 are very diverse. The phylogenetic analysis of the full-length capsid genes of both types of Tast-V shows that both may have originated from separate introductions into the turkey species and that there are at least two lineages which are distinct subtypes instead of serotypes. There are potential serotypes to appear within each subtypes. A computer analysis was done by Jonassesen et.al. that focused on the ORF1a gene ...
Until today, classic human astroviruses have not been associated with central nervous system infections in immunocompetent patients. A 16-month-old Caucasian girl presented with repetitive generalized seizures with a 4-day history of watery diarrhea, which had already gradually improved. Initially, the prolonged seizures ceased after systemic midazolam treatment and were thought to be fever associated. However, her mental status remained altered, and after seizure recurrence, she was transferred to our pediatric intensive care unit. Seizure control was achieved by a combination of high-dose levetiracetam and phenobarbital, but she remained unconscious. An electroencephalogram at this time revealed generalized high voltage theta activity. All laboratory analyses, including extended blood and cerebrospinal fluid analyses, and a brain magnetic resonance imaging were normal. On day 4, the child gradually became conscious, but was very agitated and not able to walk. Since an electroencephalogram at this time
The etiology of a large proportion of gastrointestinal illness is unknown. In this study, random Sanger sequencing and pyrosequencing approaches were used to analyze fecal specimens from a gastroenteritis outbreak of unknown etiology in a child care center. Multiple sequences with limited identity to known astroviruses were identified. Assembly of the sequences and subsequent reverse transcription-PCR (RT-PCR) and rapid amplification of cDNA ends generated a complete genome of 6,586 nucleotides. Phylogenetic analysis demonstrated that this virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all previously described astroviruses. Based on RT-PCR, specimens from multiple patients in this outbreak were unequivocally positive for Ast-VA1. ...
Reverse genetics systems enable the manipulation of viral genomes and therefore serve as robust reverse genetic tools to study RNA viruses. A DNA-launched rescue system initiates the transcription of viral genomic cDNA from eukaryotic promoter in transfected cells, generating homogenous RNA transcripts in vitro and thus enhancing virus rescue efficiency. As one of the hazardous pathogens to ducklings, the current knowledge of the pathogenesis of duck astrovirus type 1 (DAstV-1) is limited. The construction of a DNA-launched rescue system can help to accelerate the study of the virus pathogenesis. However, there is no report of such a system for DAstV-1. In this study, a DNA-launched infectious clone of DAstV-1 was constructed from a cDNA plasmid, which contains a viral cDNA sequence flanked by hammerhead ribozyme (HamRz) and a hepatitis delta virus ribozyme (HdvRz) sequence at both terminals of the viral genome. A silent nucleotide mutation creating a Bgl II site in the ORF2 gene was made to distinguish
The small, single-stranded positive-sense RNA astroviruses are mostly known to be enteric viruses. In recent years, though, different astroviruses were reported in association with neurological disease in various species. In cattle, two distinct neurotropic astrovirus genotype species were described in numerous cases of nonsuppurative encephalomyelitis, with one of these viruses also reported in similar circumstances in several sheep. Here, we retrieved archived formalin-fixed, paraffin-embedded brain tissues of a muskox diagnosed with a comparable disease pattern in 1982 and investigated them for the presence of neurotropic astroviruses with various techniques. Initially, tissue samples scored positive for both neurotropic astroviruses by immunohistochemistry; however, unexpected results with further immunohistochemical testing, in situ hybridization and qRT-PCR prompted us to submit an RNA extract from the animals brain material to next-generation sequencing. We were thus able to obtain the full
Astrovirus infections cause gastroenteritis in mammals and have been identified as causative agents of diverse pathologies in birds such as hepatitis in ducks and poult enteritis mortality syndrome...
Most astrovirus infections in humans are detected in the winter months (in temperate regions) and in the rainy season (in tropical climates). Incubation period: 3-4 days Associated diseases: gastroenteritis, celiac disease, intussusception (Fields 622). Symptoms: diarrhea in 72% - 100% in all cases, duration from 2-3 days Abdominal pain: 50% Vomiting: 20% - 70% Fever…
A study of intestinal disease in the UK, published in 1999 determined incidence as 3.8/1000 patient years in the community (95%CI, range2.3-6.4), the fourth most common known cause of viral gastroenteritis. Studies in the USA have detected astroviruses in the stools of 2-9% of children presenting symptoms; illness is most frequent in children of less than two years, although outbreaks among adults and the elderly have been reported. Early studies carried out in Glasgow demonstrated that a significant proportion of babies excreting virus particles, 12%, did not exhibit gastrointestinal symptoms, and seroprevalence studies carried out in the US have shown that 90% of children have antibody to HastV-1 by age 9, suggesting that (largely asymptomatic) infection is common. There is, as with most viral causes of gastroenteritis, a peak of incidence in the winter.. ...
Kemenesi G, Dallos B, Görföl T, Boldogh S, Estók P, Kurucz K, Kutas A, Földes F, Oldal M, Németh V, Martella V, Bányai K, Jakab F: Molecular survey of RNA viruses in Hungarian bats: discovering novel astroviruses, coronaviruses and caliciviruses, VECTOR-BORNE AND ZOONOTIC DISEASES 14: (12) pp. 846-855 ...
These RNA viruses are said to cause about 5% of infant gastroenteritis (range, 2%-9%). Symptoms are various combinations of vomiting and diarrhea, lasting 0.5-4.0 days. They originally were identified by EM of stool specimens. Culture is also possible using special procedures. EIA test methods using homemade reagents have been described.. ...
Astrovirus, Serotype 1 antibody LS-C543605 is an HRP-conjugated mouse monoclonal antibody to astrovirus Astrovirus, Serotype 1. Validated for ELISA and WB.
The Miami Marlins received no new positive results in their latest round of coronavirus testing, MLB said, but second baseman Isan Díaz also opted out.. The Philadelphia Phillies, meanwhile, were permitted to access Citizens Bank Park for staggered workouts beginning in the afternoon. MLB said no Phillies players have tested positive for COVID-19 in the past week and while three staff members have tested positive, it appeared two were attributable to false positives and the third, based on the timing of the positive test, may not have contracted COVID-19 from the Marlins. MLB rescheduled the postponed Phillies-Yankees games of this week for next week, in New York on Monday and Tuesday and in Philadelphia on Wednesday and Thursday. New Yorks game at Tampa Bay on Thursday was rescheduled as part of a doubleheader on Aug. 8.. "What the virus has taught us is this is a day-by-day, week-by-week situation that we live in," Yankees manager Aaron Boone said.. Miami will play a four-game series in ...
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Baseballs 2013 playoffs officially start tonight with three games in three days to determine who will take the National and American League wildcard spots. MLB Network analyst Harold Reynolds joins
The Dodgers officially start the 14 MLB season on Saturday with a two-game series against the D-Backs in Sydney, but no other dish, cable or telecom system has picked up Time Warner Cable SportsNet LA, according to Tom Hoffarth of the L.A. DAILY NEWS. That leaves only TWC subscribers --
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GAMMONSDAILY.coms Scott Butler noted the Phillies drew over 3 million fans this season, but dropped from 1st to 8th in MLB attendance. Average attendance dropped from 38,522 through 60 home games to 32,834 in the last 20, a 15% decrease. The Phillies will have their first losing season since 02, a
With a shortened season and the trade deadline on Aug. 31, MLB general managers are uneasy about making aggressive moves, but also see opportunity .
LAKE BUENA VISTA, Fla. -- The Dodgers post-clinch pool party on the D-backs turf was only a symbolic splash representing the larger lapping that had occurred in the seasons second half.. Bless their gritty little hearts, the D-backs could not keep up with a Dodgers club overloaded with resources. And the sting of the D-backs second-place standing not only erased any sense of certainty regarding the statuses of Kevin Towers and Kirk Gibson beyond the coming year (their 2015 contract options were not exercised) but also emboldened Arizonas offseason outlook as the club prepares for a 2014 season that features an Aussie opening against those very Dodgers.. "We owe those guys" is how managing general partner Ken Kendrick termed it recently to MLB.com, and the push for payback is assisted this offseason with a deep prospect pool (a different pool, mind you, than the one that rests at Chase Field) and a rumored willingness to push the payroll past the $100 million mark for the first time in ...
The Braves Fredi Gonzalez became the first MLB manager to be fired this season. Will beleaguered Brad Ausmus of the Tigers be next? Jay Jaffe weighs in.
The Yankees won a marathon game 5-4 in 18 innings, completing a three-game sweep of the Cubs. The teams set an MLB record for combined strikeouts with 48.
Betting analysis for the 2011 MLB season matchup between Cleveland and LA Angels. Includes ats, over/under and straight up odds analysis.
30 posts published by fanaticalstability, Jonathan Hacohen, samevans87, Jake Dal Porto, saulwizz, chuckbooth3023, kholland13, nross56, planguzzi, bkrobinson, bernieolshansky, and MLB reports during December 2012