MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level. While they have been implicated in various diseases, the profile changes in allergen inhalation challenge are not clarified in human. We aimed to evaluate changes in the microRNA profiles in the peripheral blood of asthmatic subjects undergoing allergen inhalation challenge. Seven mild asthmatic subjects participated in the allergen inhalation challenge. In addition, four healthy control subjects (HCs) were recruited. MicroRNA profiles in peripheral blood samples (pre-challenge and 2 hours post-challenge) were measured by the NanoString nCounter assay to determine changes in miRNA levels as these asthmatic subjects underwent an allergen inhalation challenge. One common miRNA, miR-192, was significantly expressed in both comparisons; HCs vs. pre-challenge and pre- vs. post-challenge, showing that miR-192 was significantly under-expressed in asthmatics compared to HCs and decreased in post-challenge at an

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ABSTRACT. Purpose. To review the characteristics of difficult-to-treat asthma and describe patients who may benefit from therapy with the recently approved humanized monoclonal anti-immunoglobulin E (IgE) antibody, omalizumab.. Principal findings. Up to 20 percent of patients have difficult-to-treat asthma. These patients consume a disproportionate share of asthma care resources. Clinical and economic outcomes can be improved via improved self-management, increased adherence to prescribed therapy, and better compliance to national asthma treatment guidelines. These patients also may benefit from therapies that directly target mechanisms responsible for persistent airway inflammation and elicit favorable clinical responses.. Conclusions. Effective asthma control remains difficult in a small cohort of patients with persistent, severe airway inflammation. Management strategies that improve asthma control and reduce exacerbations can improve clinical outcomes and minimize health care resource ...

The effect of weather on asthma symptoms isnt fully understood, but clearly there is a link. Numerous studies have shown a variety of connections, such as increases in asthma-related emergency department visits when certain weather conditions are present. Some people find that their asthma symptoms get worse at specific times of year. For others, a severe storm or sudden weather change may trigger an attack.. Exposure to cold, dry air is a common asthma trigger and can quickly cause severe symptoms. People with exercise-induced asthma who participate in winter sports are especially susceptible. Dry, windy weather can stir up pollen and mold in the air, leading to problems for some people.. Hot, humid air also can trigger asthma symptoms, and wet weather encourages the growth of mold spores, another asthma trigger. In certain areas, heat and sunlight combine with pollutants to create ground-level ozone, which is also an asthma trigger.. Studies have shown that thunderstorms can trigger asthma ...

INTRODUCTION: asthma is a chronic inflammatory and a heterogeneous condition of respiratory system whose pathogenesis is linked with variable structural changes. The clinical manifestation of asthma includes attacks of breathlessness, cough, chest tightness and wheezing. Provision of basic equipment and test for asthma diagnosis and access to essential medicines by asthmatic patients reduces morbidity and mortality rates. Significant progress has been made in the diagnosis and management of asthma in other countries but not in the health care delivery system in Zimbabwe. Therefore, the aim of this study was to develop algorithm for asthma diagnosis and management for Zimbabwe. METHODS: a two stage Delphi model was used to collect data in order to develop an algorithm of asthma diagnosis and management. A baseline interview with 44 doctors was done to understand their experiences and knowledge regarding asthma diagnosis and management. We collected data using the KoBo Collect Toolbox installed on Android

Millions of children with asthma heading back to classrooms this fall will be greeted by an increasing number of school-based asthma education initiatives, and adult patients around the U.S. are getting more access to these types of patient education programs, as well. Now, the new asthma care guidelines from the National Asthma Education and Prevention Program (NAEPP) at the National Institutes of Health (NIH), has made patient education a major priority in their new guidelines.. It is well-known that patient education is the cornerstone of quality care and outcomes for asthma patients, as it is for other diseases, says Mary Brasler, MSN, EdD, Director of Programs for the Asthma and Allergy Foundation of America (AAFA), the leading national asthma patient advocacy group and a member of the NAEPP schools committee. Simply put, if people are taught asthma self-management skills, they are more likely to adhere to their treatment plans and their health improves.. Public health experts agree ...

National Heart, Lung, and Blood Institute - So You Have Asthma: A Guide for Patients and Their Families This booklet offers the latest information on asthma management. In an easy-to-read format, it provides information about asthma symptoms, the latest treatments, and ways to monitor and keep your asthma under control. This site also includes the Clinical Guidelines for the Diagnosis and Management of Asthma and What Is Asthma?. The American Lung Associations (ALA) Asthma Basics The Asthma Basics course is a free, one-hour interactive online learning module designed to help people learn more about asthma. This course is ideal for frontline healthcare professionals like nurses or community health care workers, as well as individuals who have asthma. Asthma Basics also includes comprehensive resources like asthma medication devices, and demonstration videos and downloads. This course is also available in Spanish.. Living with Asthma - National Jewish Health. National Jewish Health website ...

According to the California Work-Related Asthma Prevention Program, part of the Occupational Health Branch of California Department of Public Health, cleaning products used in workplaces can cause or trigger work-related asthma. To prevent harsh affects of cleaning products, employers should make sure the safest products and practices are used in the workplace. The program has found that nearly 10 percent of all work-related asthma cases were caused by exposure to cleaning products. Most of these cases had new asthma that started only after they began work - the exposures caused their asthma. About one in five people (almost 20 percent) used cleaning products directly, such as janitors. The other 80 percent of workers attributed their asthma symptoms to cleaning products used nearby. Many workplaces, like schools, hospitals, and restaurants are places where everyone, including children, can be affected by cleaning products. How can asthma from cleaning products be prevented? ...

Stanbrook and Kaplan have previously suggested that physicians who do not use spirometry for their asthma patients should not be managing asthma.1 They have put forth the notion that asthma management without spirometry testing would be considered failing to maintain an adequate standard of care, and that most primary care physicians need to make testing available in their own offices.1 They developed this theme based on a study by Aaron et al,2 whose results actually revealed that asthma diagnosis was confirmed in 16% and 72% of patients studied, by spirometry and methacholine challenge testing, respectively. Building a case for office spirometry based on these results seems counterintuitive.3 Further, Stanbrook and Kaplan did not cite a single reference in their article that described how widespread use of office spirometry in primary care might influence asthma outcomes in patients not previously diagnosed with asthma.1. Spirometry can provide important information about lung function and ...

Surveillance data from four states on work-related asthma are now available online from the Work-Related Lung Disease Surveillance System (eWoRLD), developed and maintained by CDCs National Institute for Occupational Safety and Health. Work-related asthma data presented through this surveillance system include information on associated industry, occupation, and exposures. Tables using data from California, Massachusetts, Michigan, and New Jersey for the period 1993-2006 now are available online from eWoRLD at http://www2a.cdc.gov/drds/worldreportdata/subsectiondetails.asp?archiveid=1&subsectiontitleid=23. More years of state-based work-related asthma data will be posted online as they become available. Additional information about the state-based work-related asthma program is available at http://www.cdc.gov/niosh/topics/surveillance/ords/statebasedsurveillance.html. ...

Asthma is a chronic disease that causes constriction of the airways. People with asthma may experience wheezing, coughing, chest tightness, and trouble breathing. Although asthma is a major public health problem among Puerto Ricans, little research has been done to determine the influence of heredity and environment on the disease in this population. To learn more about these relationships, this study will examine the effects of certain genes and allergens on the development and severity of asthma in Puerto Rican children.. This observational study will recruit both children with asthma and children without asthma. Participants will meet with study staff twice during the study. The first visit will take place at participants homes. Participants will complete questionnaires about demographics, respiratory and general health, and household characteristics. Lung function testing, collection of blood samples, and collection of household dust samples will also take place at the home-based visit. The ...

In the 1990s, healthcare professionals and community advocates recognized an alarming rise in uncontrolled asthma, especially in low-income communities and communities of color. Between 1988 and 1995, hospitalizations for asthma in low-income communities in Seattle and South King County more than doubled, and were twice the rate of the general King County population.. Growing evidence showed that indoor asthma triggers such as dust mites, smoke, mold, and roaches were major contributors to poor asthma control. Local data demonstrated that in King County, low-income people were more likely to live in substandard housing, exposing them to these triggers.. A new approach to asthma care. Alarmed by this rise in asthma, a coalition of clinicians, public health officials, the American Lung Association, and community health advocates designed a pilot project to help low-income families manage asthma triggers in their homes.. While the cause [of the rise] was not clear, it was clear that people with ...

TY - JOUR. T1 - Different seasonal effect on asthma trajectories. T2 - A population-based birth cohort study. AU - Wu, Tsung Ju. AU - Pan, Shih Chun. AU - Chen, Bing Yu. AU - Chin, Wei Shan. AU - Guo, Yue Leon. PY - 2018/12/1. Y1 - 2018/12/1. KW - adolescence. KW - asthma phenotype. KW - atopic disease. KW - children. KW - group-based trajectory model. KW - season. KW - urbanization. KW - adolescence. KW - asthma phenotype. KW - atopic disease. KW - children. KW - group-based trajectory model. KW - season. KW - urbanization. UR - http://www.scopus.com/inward/record.url?scp=85054172925&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85054172925&partnerID=8YFLogxK. U2 - 10.1111/pai.12973. DO - 10.1111/pai.12973. M3 - Letter. C2 - 30144172. AN - SCOPUS:85054172925. VL - 29. SP - 873. EP - 877. JO - Pediatric Allergy and Immunology. JF - Pediatric Allergy and Immunology. SN - 0905-6157. IS - 8. ER - ...

Over-proliferation of airway smooth muscle cell (ASMC) is one of the important contributors to airway remodeling in asthma. The aim of this study was to investigate the effect of Shenmai injection (SMI) on the proliferation of the rat ASMC in asthma. Rats were randomly divided into three groups: the control group, the asthma group, and the SMI treatment group. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry staining were used to detect the mRNA and protein expression of transient receptor potential vanilloid 1 (TRPV1) and proliferating cell nuclear antigen (PCNA) in rat ASMC respectively. Intracellular Ca2+ concentration ( [Ca2+]i ) in rat ASMC were measured with Fluo-3/AM by confocal microscopy. The proliferation was detected by MTT assay. Compared with the control group, the asthma group showed an increased expression of TRPV1 and [Ca2+]i in rat ASMC. The expression of PCNA and absorbance of MTT assay in asthma rat ASMC was also significantly increased. SMI could

Children whose parents perceived their lives as unpredictable, uncontrollable, or overwhelming had increased risk of new onset asthma associated with TRP and maternal smoking during pregnancy. Furthermore, susceptibility to TRP attributable to parental education was markedly attenuated after accounting for the susceptibility attributable to parental stress. While parental stress may influence the development of asthma in a child due to biological and behavioral pathways other than psychological stress in children (26), the observed pattern of susceptibility to air pollution based on stress was not explained by potentially relevant history of illness and a range of behavioral, socioeconomic, and environmental risk factors for asthma. Although there were relatively few children with a history of in utero tobacco smoke exposure, significantly larger effects were observed both among children with low parental education and with high parental stress. Thus, common biological pathways may underlie the ...

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There is increasing evidence that neutrophils are involved in acute asthma exacerbation. Prominent neutrophilic inflammation has been demonstrated during exacerbated asthma inadult patients 2-8. Recently, inflammatory profiles of asthmatic airways in children have been assessed by analysing sputum and/or BAL fluid 9-11. These studies proposed that neutrophil-mediated inflammation was also involved in the pathophysiology of exacerbation of childhood asthma. However, the nature of airway inflammation in childhood asthma and its severity have not been adequately evaluated because bronchoscopic studies or BAL fluid analysis can be too invasive for children.. There are several lines of evidence that activation of NE is involved in asthma exacerbation and results in hypersecretion by mucous-producing cells 8, 12, 13. In BAL fluid of asthmatic subjects, excessive secretion of proteinases, including NE and MMPs, has been observed during acute asthma exacerbation 12, 19. However, it is hard to detect ...

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The original authors main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.. Objective criteria for interpretation of peak expiratory flow rate readings were assessed in 50 patients evaluated for suspected occupational asthma who had at least two weeks of PEFR readings and an objective diagnosis based on other investigations. The prevalence of occupational asthma was 36 percent. Peak flows were interpreted by two observers blinded to other results. Criteria for a PEFR interpretation of occupational asthma were as follow: diurnal variation greater than or equal to 20 percent relatively more frequently or with greater variation on working days than days off work. With the objective diagnoses as the gold standard, the sensitivity of the PEFR interpretations was 72 percent for OA; specificity for no asthma was 53 percent. Excluding those with greater than or equal to 20 ...

Theres a tremendous disparity there, said Wendy Brunner an epidemiologist for the Minnesota Department of Health Asthma Program.. The program tracks a number of asthma measures, among them emergency department visits, smoking rates, second-hand smoke exposure by people with asthma, rates of flu and pneumonia vaccinations for asthma sufferers and asthma deaths.. Brunner said where people live can explain much of the racial disparity in asthma rates. Like Jackson and her son, many low-income people turn to rentals where they may have less control over their living conditions.. We know in Minnesota that African Americans have the lowest home ownership rate in the state and that has implications for somebody with asthma, Brunner said.. Rental housing can have old, dirty carpets -a big asthma trigger. Tobacco smoke from nearby apartments may seep into the units where people with asthma live. In many cases, theres nothing a renter can do about these problems. Landlords may prevent them from ...

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In the present study, the relationship between airway inflammation and infection with C. pneumoniae in acute asthma was examined. It was found that over one-third of adults presenting with acute severe asthma showed a rise in C. pneumoniae-specific antibodies consistent with acute infection, reinfection or reactivation of latent infection with C. pneumoniae. These subjects exhibited a more intense inflammatory response during the acute exacerbation, with an increase in sputum TCC, neutrophil count and ECP level compared to subjects with acute asthma who did not show an increase in C. pneumoniae antibody levels.. Subjects were recruited from patients presenting to the emergency department with acute asthma, who had at least moderate airflow obstruction, representing a group with more severe acute asthma. This group was selected for study based on previous work linking C. pneumoniae infection with asthma exacerbations and severe asthma 6, 7, 14. The sputum induction time tended to be shorter at ...

Boston, Mass.-May 2, 2012) The Connecticut Childrens Medical Center is one of four winners nationwide of the 2012 National Environmental Leadership Award in Asthma Management for its Easy Breathing Program, which includes patient education and environmental interventions. The program is implemented across the state of Connecticut helping ensure that comprehensive asthma care is available to the 105,000 children with asthma now enrolled in the program. The Easy Breathing Program is designed to aid primary care clinicians in making a diagnosis of asthma and treating individuals using a systematic, standardized, approach which adheres to the National Asthma Education and Prevention Program (NAEPP) guidelines. It was the first large scale program in the country to demonstrate that clinicians can use NAEPP guidelines and that its effective use can result in improved quality of asthma care. One of the distinguishing features of this program is the creation of a robust database which is used for ...

The inter-relationship between the perception of bronchoconstriction, bronchial hyper-responsiveness and temporal adaptation in asthma is still a matter of debate. In a total of 52 stable asthmatic patients, 32 without airway obstruction [forced expiratory volume in 1 s (FEV1)/vital capacity (VC) 84.1% (S.D. 7.9%)], and 20 with airway obstruction [FEV1/VC 60% (4%)], we assessed the perception of bronchoconstriction during methacholine inhalation by using: (i) the slope and intercept of the Borg and VAS (Visual Analog Scale) scores against the decrease in FEV1, expressed as a percentage of the predicted value; and (ii) the Borg and VAS scores at a 20% decrease in FEV1 from the lowest post-saline level (PB20). Bronchial hyper-responsiveness was assessed as the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20FEV1). The reduction in FEV1 was significantly related to the Borg and VAS scores, with values for the group mean slope and intercept of this relationship of 0.13 ...

Status asthmaticus is the most common medical emergency in children today and is responsible for nearly half a million hospital admissions annually. Despite evidence that asthma hospitalizations are decreasing, asthma mortality is not. In order to gain a better understanding of status asthmaticus, its treatment, and its overall outcomes, each PICU research team within the Collaborative Pediatric Critical Care Research Network (CPCCRN) examined its admissions records in detail for children aged from 1 year up to the 18th birthday over the last 5 years for any instances of deaths resulting from a diagnosis of asthma (fatal asthma). Post-mortem data was reviewed where available. In addition, the medical records for children intubated and mechanically ventilated for asthma (near-fatal asthma) were analyzed. This review and abstraction has enabled CPCCRN investigators to quantify the current variability of critical asthma treatment and has helped us to identify additional medical problems, such as ...

Twenty-five patients with severe childhood asthma were treated with beclomethasone dipropionate. 21 of these children were receiving oral corticosteroid therapy in addition to disodium cromoglycate.. Of the total treated, 21 children improved or maintained their asthma status on this treatment over an average period of 4 months, and were able to reduce and stop their regular oral corticosteroid dosage, but 4 children had to revert to their original therapy.. No systemic or local toxic effects were experienced by any of the children.. Beclomethasone dipropionate appears to be an effective drug in the treatment of severe childhood asthma in those patients who need corticosteroid therapy in addition to disodium cromoglycate.. ...

Telehealth has the potential to improve asthma management through regular monitoring of lung function and/or asthma symptoms by health professionals in conjunction with feedback to patients. Although the benefits of telehealth for improving asthma management have been extensively studied, the feasibility of telehealth for supporting asthma management in pregnant women has not been investigated. This study aims to evaluate the use of telehealth for remotely monitoring lung function and optimising asthma control during pregnancy. A randomised controlled trial comparing usual care with a telehealth program (MASTERY©) has been conducted. The intervention comprised a mobile application - Breathe-easy © supported by a Bluetooth-enabled handheld device (COPD-6®), which was used for self-monitoring of lung function (FEV1, FEV6) twice daily, and recording asthma symptoms and medication usage weekly; and a written asthma action plan (WAAP). The primary outcome measure is

TY - JOUR. T1 - Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. AU - Carino, Mauro. AU - Aliani, Maria. AU - Licitra, Carmelo. AU - Sarno, Nicola. AU - Ioli, Francesco. PY - 1997/1. Y1 - 1997/1. N2 - Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.. AB - Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the ...

In the second part of this respiratory health special report, Bernard Garbe looks at how serial peak expiratory flow can be used to identify occupational asthma.. The first part of the report explores the 2010 BOHRF Occupational Asthma Guidance on sensitiser-induced occupational asthma.. In occupational health, lung disease is the most common form of disease encountered after skin problems. Occupational lung diseases include byssinosis (typically cotton dust), allergic rhinitis, farmers lung, asbestosis, pneumoconiosis (most commonly coal dust), silicosis and chronic obstructive pulmonary disease (COPD). While COPD has the greatest mortality rate, occupational asthma (OA) has by far the greater incidence. OA, by definition, is a lung disease caused by occupational exposures and is the cause of about 15% of adult-onset asthma. Occupational asthma often results in skilled and experienced people having to end their careers, in many cases without a confirmed diagnosis. In nearly half the diagnosed ...

Asthma is a chronic and heterogenic respiratory tract disorder with a high global prevalence. The underlying chronic inflammatory process and airway remodeling (AR) contribute to the symptomatology of the disease. The most severely ill asthma patients may now be treated using a variety of monoclonal antibodies aiming key inflammatory cytokines involved in asthma pathogenesis. Although clinical data shows much beneficial effects of biological therapies in terms of reduction of exacerbation rates, improvement of lung functions, asthma control and patients quality of life, little is known on the effects of these monoclonal antibodies on AR-a key clinical trait of long-term asthma management. In this review, the authors summarize the data on the proven effects of monoclonal antibodies in asthma on AR. To date, in terms of reversing AR, the mostly studied was omalizumab. However, some studies also addressed this clinical issue in context of other severe asthma biological therapies (mepolizumab, benralizumab

This study is being performed to help patients and their health care team work together to make decisions about managing their asthma. A new class of medicines for asthma called asthma biologics, which target very specific immunological pathways responsible for asthma, were developed. The first such medicine, omalizumab, first became available in 2003 and 2 additional medicines, mepolizumab and reslizumab, became available in 2015 and 2016, respectively. These medicines are currently intended for those who have moderate or severe asthma and who havent responded to other asthma medicines like inhaled corticosteroids. Patients receiving asthma biologics usually have the highest burden of asthma disease. Asthma biologic medicines are very expensive and may not work for everyone. Sometimes, patients and their doctors need to make decisions about stopping asthma biologics. Right now, we do not have very good information about what happens to patients after they stop these medicines. It is important ...

Nitrogen dioxide (NO2) can enhance both early and late airway narrowing after inhaled antigen in allergic asthmatic subjects. We hypothesized that NO2 may also increase airway inflammation during the late response. Nitrogen dioxide has been shown to cause airway inflammation in healthy subjects without asthma. We also hypothesized that individuals with asthma may have increased non-allergic airway inflammation after exposure to NO2. To test these hypotheses, we designed two experiments with the following specific aims: Experiment 1) To determine the effect of a single exposure to NO2 on allergen-induced airway inflammation. Experiment Two: To determine the effect of NO2 exposure on non-allergic airway inflammation. Experiment One: 15 house dust mite (HDM)-sensitive asthmatic subjects were exposed for 3 hours to filtered air or 0.4 ppm NO2 followed immediately by inhalation of HDM allergen. Lung function was measured before and after each exposure and after allergen challenge, hourly for 6 hours. Sputum

Asthma is a chronic respiratory disease that affects over half a million children and adults living in Indiana. Asthma can be controlled but not cured. In a person with asthma, airways can swell and tighten making it hard to breathe. When an asthma attack happens, the inside of the airways swell and fill with mucus. The muscles around the airways tighten. This makes the airways smaller. Some of the most common symptoms of asthma include wheezing, shortness of breath, tightness in the chest, and coughing.. People with asthma can help control their symptoms by managing triggers in their environment. Triggers include anything that brings on asthma symptoms, and they differ for each person with asthma. Some triggers include dust mites, cigarette smoke, perfumes and fragrances, mold, pet dander, cockroaches, and stressful or emotional situations.. People with asthma should talk to their doctor about developing an asthma action plan. Asthma action plans help people with asthma to manage their ...

Essentially, airway remodeling is the result of chronic inflammation in the airways that goes untreated long-term. This is added evidence that asthma should be treated aggressively with inhaled corticosteroids early on in the course of the disease to prevent permanent airway damage and worsening asthma ...

It wasnt easy getting to this point, though. This can work as a natural anti-inflammatory agent. I agree with the change to a corticosteroid inhaler minus the long acting bronchodilater. Make a wire mould similar in size and shape to the mouthpiece of the MDI [metered-dose inhaler]. Depending on where your asthma control falls on the chart, you may need to make adjustments to your medications. Why do inhalers make me feel better if I dont have asthma? Tools for asthma control. Your written asthma action plan will let you know exactly when and how to make adjustments. Thats why ginger tea is a great alternative to stop asthma naturally. While asthma causes symptoms that challenge breathing, you can participate in any activity as long as you manage your asthma symptoms, notes the American Lung Association. The Buteyko method teaches you to breathe slowly and calmly through your nose instead of your mouth. Before embarking on any home remedy, it is important to speak with your doctor to ensure ...

There was only one problem. As more data came in, they failed to tell the same story as the hygiene hypothesis. Children in Latin America with high rates of supposedly protective infection have even higher rates of asthma than children in western Europe. Inner-city children in Chicago and New York have quite high rates of asthma, despite unhygienic living. And the rates of asthma varied among countries with very similar histories of cleanliness-indicating that there was more to it than tidiness. For example, by 2004 Swedens asthma cases had increased to 10 percent, according to one international study, while the number of cases in the U.K. had soared to 20 percent.. In addition, research showed that the relation between asthma and allergy is not at all straightforward. Some cases of asthma are indeed triggered by allergies, although the consensus among researchers over the past decade is that the connection is probably not as clear-cut as the hygiene hypothesis would suggest. Still other layers ...

TY - JOUR. T1 - Choosing Wisely. T2 - Adherence by Physicians to Recommended Use of Spirometry in the Diagnosis and Management of Adult Asthma. AU - Sokol, Kristin C.. AU - Sharma, Gulshan. AU - Lin, Yu Li. AU - Goldblum, Randall M.. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Purpose: The National Asthma Education and Prevention Program (NAEPP) and the American Thoracic Society provide guidelines stating that physicians should use spirometry in the diagnosis and management of asthma. The aim of this study was to evaluate the trends, over a 10-year period, in the utilization of spirometry in patients newly diagnosed with asthma. We hypothesized that spirometry use would increase in physicians who care for asthma patients, especially since 2007, when the revised NAEPP guidelines were published. Methods: This retrospective cohort analysis of spirometry use in subjects newly diagnosed with asthma used a privately insured adult population for the years 2002-2011. Our primary outcome of interest was ...

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Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly. Asthma and other airway disorders are among the most common causes of chronic cough; and cough can be the sole symptom of asthma. Little is known about why some patients with asthma primarily cough and do not develop the other symptoms of asthma such as shortness of breath or wheeze. Improved understanding of the reasons for these different manifestations may lead to new and more effective treatment strategies. We have notices differences in pressure measurements inside the chest in patients who mostly cough during induced bronchoconstriction, which might be part of the explanation for varying symptoms. This study will compare lung mechanical responses during methacholine and mannitol-induced induced airway narrowing between typical asthma, cough variant asthma (CVA) and an airway inflammatory disorder that ...

Asthma is a chronic inflammatory airway disease induced by many environmental factors. The inhalation of allergens and pollutants promote the reactive oxygen species (ROS) production leading to airway inflammation, hyper-responsiveness and remodeling in allergic asthma. The effects of asthma medications on ROS production are unclear. The present study investigated the anti-ROS effects of current asthma medications including inhaled corticosteroid (ICS; budesonide and fluticasone), leukotriene receptor antagonist (LTRA; montelukast), long acting β2 agonists (LABAs; salmeterol and formoterol) and a new extra-LABA (indacaterol). The human monocyte cell line THP-1 cells were pre-treated with different concentrations of the asthma medications at different time-points after hydrogen peroxide (H2O2) stimulation. H2O2 production was measured with DCFH-DA by flow cytometry. Montelukast, fluticasone and salmeterol suppressed H2O2-induced ROS production. Indacaterol enhanced H2O2-induced ROS production.

The Adult Asthma Program at Boston Medical Center provides a multidisciplinary diagnostic evaluation and tailored therapeutic plan for patients with asthma and related allergic lung disease, including allergic bronchopulmonary aspergillosis (ABPA) and hypersensitivity pneumonitis. Our mission is to improve the lives of patients living with asthma and allergic lung disease by providing state-of-the-art patient care.. The staff includes physicians who are double board-certified in Pulmonary Diseases (ABIM) and the American Board of Allergy and Immunology. As a result, testing/treatment for allergy to possible environmental triggers is ordered and interpreted in the clinic as part of our comprehensive care including allergy skin testing, allergy immunotherapy (allergy shots), anti-IgE therapy, and other more recently approved biologics. In addition, the team includes nurse practitioners who specialize in asthma disease management and training to provide targeted asthma education.. Our patient ...

Supporting self-management behaviours is recommended guidance for people with asthma. Preliminary work suggests that a brief, intensive, patient-centred intervention may be successful in supporting people with asthma to participate in life roles and activities they value. We seek to assess the feasibility of undertaking a cluster-randomised controlled trial (cRCT) of a brief, goal-setting intervention delivered in the context of an asthma review consultation. A two armed, single-blinded, multi-centre, cluster-randomised controlled feasibility trial will be conducted in UK primary care. Randomisation will take place at the practice level. We aim to recruit a total of 80 primary care patients with active asthma from at least eight practices across two health boards in Scotland (10 patients per practice resulting in ~40 in each arm). Patients in the intervention arm will be asked to complete a novel goal-setting tool immediately prior to an asthma review consultation. This will be used to underpin a

TY - CHAP. T1 - Eosinophils. AU - Lee, Nancy A.. AU - Dahl, Mark V.. AU - Jacobsen, Elizabeth A.. AU - Ochkur, Sergei I.. PY - 2011/7/27. Y1 - 2011/7/27. KW - Allergic, nonatopic asthma - allergic asthma, observed in atopic patients. KW - Asthma in humans, three groups - nonatopic allergic asthma, asthma associated with allergies and atopic asthma. KW - Eosinophil numbers, increasing in presence - of allergic disease, as asthma, AD and hay fever. KW - Eosinophil presence, in airway allergic disease - and inflammation in respiratory tract. KW - Eosinophils and T cells - cooperating in asthmatic inflammation. KW - Eosinophils and asthma - disease of lungs and airways, pathologies outside lungs, as well. KW - Eosinophils, classical view of eosinophils - as destructive effector cells, killing cells or tissues indiscriminately. KW - Nonallergic asthma, not often responsive - to prednisone treatment. KW - T cells, and eosinophils - key immune modulators and remodeling agents in asthma. KW - T cells, ...

p,Asthma is a chronic respiratory disease which is characterized by reversible bronchoconstriction, airway hyperresponsiveness, and airway inflammation. Allergen inhalation by sensitized atopic asthmatics enhances airway hyperresponsiveness and inflammation, providing a model to study mild asthma exacerbation. Airway inflammation can be measured non-invasively from airway secretions by sputum induction. Prior to starting this thesis, information on allergen-induced inflammation measured from sputum was limited. Furthermore, the pro- or anti-inflammatory effects of asthma therapies had not been investigated using this model of allergen-induced airway inflammation. The aim of this thesis was to first characterize the allergen-induced changes in sputum inflammatory cells and determine the repeatability of measurements of sputum inflammatory cells following allergen inhalation challenge. In addition, this thesis was aimed to investigate the pro- or anti-inflammatory effects of asthma therapies on ...

In 2011, an estimated 8.2% of adults aged ≥18 years reported current asthma (http://www.cdc.gov/asthma/nhis/2011/table4-1.htm). A case-control study conducted in Tennessee, which identified cases through active, population-based and laboratory-based surveillance and verified history of asthma from the Tennessee Medicaid database, showed that among adults aged 18-49 years, invasive pneumococcal disease (IPD) was more common among persons with asthma than persons without asthma (adjusted odds ratio =2.4; 95% confidence interval =1.8-3.3).4 Among persons with high-risk asthma, the risk for IPD was nearly twice that for persons with low-risk asthma.4 In contrast, in a study conducted among a cohort of older veterans (average age: 53 years), persons with asthma did not have higher rates of hospitalization for pneumococcal pneumonia compared with persons in a group without asthma or chronic obstructive pulmonary disease (COPD) who were matched to the asthma patients by age, sex, and region.5 ...

In this historical cohort study, we found that infants of asthmatic women, as compared with nonasthmatic control women, were more likely to exhibit transient tachypnea of the newborn. We also observed that the association between maternal asthma and transient tachypnea of the newborn was more pronounced in term births as opposed to preterm births and in infants of male sex as opposed to infants of female sex.. Strengths of the present study included: 1) large sample size; 2) historical cohort design; 3) extensive control for potentially confounding variables; 4) stratified analysis by gestational age and sex.. Several limitations of our study must be kept in mind. Administrative databases are prone to some degree of coding errors.26Because the analyses reported here depend on the patient data recorded at the time of obstetrical delivery, it is possible that only mothers with severe or active asthma would have been identified as such and mothers with less severe or inactive asthma may have been ...

Bermuda Hospitals Board (BHB) invites the public to an Asthma Day Open House on Thursday 6 May from 8:30am to 2:30pm in the hospital lobby. Asthma and allergy education and free spacer devices will be provided to anyone suffering with asthma or other breathing difficulties. Adult lung screening will also be offered to smokers and ex-smokers over the age of 40.. Asthma is one of the most common chronic diseases in the world, affecting more than 300 million people worldwide. It is characterized by recurrent breathing problems and symptoms such as breathlessness, wheezing, chest tightness and coughing.. Asthma affects approximately 12% of our community, explains Debbie Barboza, Asthma Nurse Educator for the Asthma Education Centre at KEMH. Thousands of people suffer unnecessarily every day because of poorly controlled asthma. Yet people can control their disease and minimize incidents with proper diagnoses, education and treatment.. While hospital admissions from asthma-related incidents are ...

Background Cough variant Asthma (CVA) is defined as chronic cough without wheezing, and may be precursor of typical asthma. Thus, the diagnosis of CVA and early intervention can partly inhibit asthma progression.This study aimed to evaluate the role of spirometry in diagniosis of Cough variant Asthma in Iranian Children. Materials and Methods This descriptive observational study included a total of 73 patients, who were referred to the specialized lung clinic of Tabriz Pediatric Center, Tabriz city, Iran. Patients were divided into two groups with classic asthma (n=37) and cough variant asthma (n=36) and basic spirometry parameters such as FEV1, FVC, FEV1/FVC, FEF 25-75% and PEF were measured, and the spirometry findings of each individual were measured based on the European Respiratory Society (ERS) criteria. Results The mean of FEV1 and FVC in the classic asthma group were 83.45 ± 20.49% and 86.45 ± 21.57%, respectively; and in the cough variant asthma group were 87.44 ± 13.99% and 86.8 ± 14.71%,

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The present case of fatal asthma attack was due to acute exacerbation of work-related asthma that developed in a plastic injection process worker with a history of asthma in remission. The deceased patient led a normal life without manifestations of asthma symptoms or any treatments. However, he began to exhibit typical late-stage asthma symptoms 4 years after working with injection process simulation. Unaware of the occupational cause of those symptoms, he continued to work and finally succumbed to an asthma attack.. Occupational asthma is classified as sensitizer- or irritant-induced asthma depending on the presence or absence of sensitization and a latency period. Sensitizer-induced asthma occurs as a result of immunologic sensitization and is preceded by a latency period after exposure to asthma-triggering substances in the workplace [8]. The latency period between exposure to the causative substances and manifestations of symptoms may range from several weeks to years depending on the phase ...

INTRODUCTION: In budesonide/formoterol (Symbicort(R) Turbuhaler(R), AstraZeneca, Lund, Sweden) maintenance and reliever therapy (SMART), patients with asthma take a daily maintenance dose of budesonide/formoterol, with the option of taking additional doses for symptom relief instead of a short-acting beta(2)-agonist (SABA). This study assesses the cost-effectiveness of SMART compared with usual care in patients with mild-to-moderate persistent asthma treated by general practitioners in the Netherlands from a societal perspective. METHODS: The study was linked to a randomized, active-controlled, open-label, multicenter, 12-month clinical trial, with a prospective collection of resource use. One hundred and two patients ,/=18 years with mild-to-moderate persistent asthma and daily inhaled corticosteroids (ICS) prior to the trial were included. SMART was given as two inhalations of budesonide/formoterol (100/6 mug) once daily, plus additional doses as needed. The control group was treated according ...

Asthma Check Peak Flow Meter Readings Chart For Adults Lung Asthma Flow Meter Chart Flowcharts asthma flow meter readings asthma flow meter chart printable asthma peak flow meter chart asthma check peak flow meter readings asthma peak flow meter readings adults One more free flowchart maker for Mac thats worth your time is Draw.io. You can use the application online or download it to your Mac. This tool also offers a crisp interface thats similar to applications youre familiar with using a simple menu at the top and helpful sidebars. Find Your Next Flowcharts

It really is a horrible condition once and for a half serving and contributing too much stomach acid indigestion and fitness program! Fruits and Vegetables.. Asthma and Gastroesophageal Reflux Disease. People with gastroesophageal reflux disease (GERD) often suffer recurrent chest distress and commonly experience asthma symptoms.. Treating GERD Helps Asthma In Children - Many asthma patients have underlying reflux and GERD has been implicated in aggravating asthma, Dr. Vikram Khoshoo, a pediatric gastroenterologist from West Jefferson Medical Center, tells Reuters Health. For the study, 62 asthmatic children (ages 6- 11) underwent esophageal acid testing.. Jul 10, 2017. But a subset of pediatric asthma patients continues to experience. Treatment of GERD in asthmatic adults and children did not improve.. on behalf of the American Lung Associations Asthma Clinical Research. in the Study of Acid Reflux in Children with Asthma (NCT00442013) were included.. esophageal reflux disease (GERD) in a ...

In the United States, asthma cases have increased significantly by about 60% in the past 30 years, with asthma related deaths now standing at 5,000 each year. With the rise in asthma cases, more patients are seeking alternative solutions to control their symptoms.. But is chiropractic care right for you? How effective is chiropractic care in diminishing your asthma symptoms? The answers will surprise you.. According to research, the skyrocketing number of asthma cases has to do with environmental variables such as increased pollution, food preservatives, mold and even genetics to name a few.. While seeing a young child with an inhaler was quite a strange site in the 1980s, today it is not that uncommon to see several kids in a classroom take out their inhalers for much needed relief. Asthma has become a huge problem and everyone agrees that future generations can expect to see even higher numbers of sufferers. Unfortunately there is no cure for asthma but there are ways to control the symptoms ...

TY - JOUR. T1 - Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses. AU - Avila, P. C.. AU - Boushey, H. A.. AU - Wong, H.. AU - Grundland, H.. AU - Liu, J.. AU - Fahy, J. V.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Background: Selectins participate in the initial phase of leucocyte migration from circulation to inflamed tissues and may play a role in inflammatory cellular influx into airways in asthma. In the sheep asthma model, TBC1269, a pan-selectin antagonist, reduced late allergen response by 74%. Objective: To determine whether a single dose of TBC1269 inhibits early (EAR) and late (LAR) asthmatic responses, and whether it inhibits sputum leucocyte influx after inhalation allergen challenge in atopic asthmatic subjects treated with bronchodilators only. Methods: Twenty-one asthmatic subjects (mean ± SD, age = 32.5 ± 6.7 years, 8 males, FEV1 percent predicted = 84 ± 15%) with known late asthmatic response based on a screening inhalation allergen ...

Monaghan Medical Corporation understands that for those with asthma, particularly children, choosing the device that best delivers their medication is an important consideration.. Plattsburgh, NY, USA - Monaghan Medical Corporation understands that for those with asthma, particularly children, choosing the device that best delivers their medication is an important consideration. Research has shown that even when using the same metered-dose inhaler (MDI), not all valved holding chambers perform equally well.[1]. A landmark real-world study involving more than 18,000 asthma patients has demonstrated superior asthma control with the AEROCHAMBER PLUS® FLOW-VU® antistatic Valved Holding Chamber (VHC) compared with other chamber devices.[2] According to the study, published in Pulmonary Therapy, use of the AEROCHAMBER PLUS® FLOW-VU® antistatic chamber resulted in delayed time to first exacerbation, fewer asthma-related emergency department visits, and lower exacerbation-related costs than control ...

Forty patients with bronchial asthma participated in this study, their age ranged between 30 and 50 years. They were divided into two equal groups, group (A) received Buteyko breathing technique (BBT), and the medications prescribed by physician, while group, (B) did not perform any physical therapy program while maintaining medications as prescribed by the physician. The program continued for 6 weeks. Peak expiratory flow rates (PEFR), Control pause test and asthma daily symptoms (asthma control questionnaire) were measured at the beginning and after the treatment program for both groups.. Results : A significant decrease in daily asthma symptoms, a significant improvement in PEFR, and Control pause in the test group (A), while there was no significant change in group (B).. Study concluded that BBT produce a significant improvement for patients with bronchial asthma as regard daily symptoms, PEFR and Control pause test.. Zahra Mohamed Hassan, Nermine Mounir Riad, Fatma Hassan Ahmed ...

Background There are ambiguous results regarding the role n-3 polyunsaturated fatty acids and fish might play in primary prevention of allergic diseases. The aim was to investigate the association between cod liver oil and fish consumption during pregnancy and in the first year of life and asthma and eczema at 2 years of age.. Methods From the Prevention of Allergy among Children in Trondheim study, a prospective birth cohort study in primary healthcare in Trondheim, Norway, 3086 children were followed prospectively from 1 year to approximately 2 years of age. The primary outcome variable was parental reported asthma and eczema at 2 years.. Results The mean age for introducing fish in the diet was 9.1 months. Excluding children with incident eczema before 1 year, a reduced risk of developing eczema was found if the child was eating fish once a week or more, adjusted OR (aOR) for any kind of fish 0.62 (95% CI 0.42 to 0.91 p=0.02), for oily fish aOR 0.21 (95% CI 0.05 to 0.86 p=0.03) and for lean ...

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Health information on the dimensions of asthma and allergic conditions in Khuzestan Province, as a major industrial and polluted area in Iran as and the Middle East, is inadequate. This study was performed to measure the prevalence of asthma and other allergic conditions in adults in Khuzestan Province. This population-based cross-sectional study was carried out in 17 villages and 27 cities of Khuzestan Province during the years 2017-2018 on 20 to 65 year old respondents. Two-stage cluster sampling was used. The ECRHS (European Community Respiratory Health Survey) questionnaire was completed for individuals with additional questions regarding other allergic conditions. In the study, 5720 questionnaires were distributed of which 5708 were returned. The prevalence of current asthma was 8.5% and that of asthma-like symptoms was 19.0%. The most common symptoms of asthma were nocturnal cough (13.6%), chest tightness (12.3%) and wheezing (13.1%). The prevalence of allergic rhinitis (AR), eczema and airway

Magnesium Supplements Reduce Childrens Asthma. A new study has found that children and adolescents with asthma who are given magnesium supplements experience less symptoms, use less medication, and experience a number of other beneficial effects. In the double-blind, randomized, placebo-controlled study, researchers investigated the long-term effect of oral magnesium supplementation on clinical symptoms, bronchial reactivity, lung function and allergen-induced skin responses in children and adolescents (ages 7 to 19 years) with moderate persistent asthma. The study included 37 patients. The subjects were randomized into two groups with 18 subjects receiving 300 mg per day magnesium and 19 subjects receiving a placebo for 2 months. Both patient groups received the inhaled asthma medications fluticasone (daily) and salbutamol (as needed). After two months, the researchers found that the children taking the magnesium supplements had, on average, 28 percent fewer days of severe asthma. The ...

TY - JOUR. T1 - Lipid profiles in children with and without asthma. T2 - Interaction of asthma and obesity on hyperlipidemia. AU - Chen, Yang Ching. AU - Tung, Kuan Yen. AU - Tsai, Ching Hui. AU - Su, Ming Wei. AU - Wang, Pei Chuan. AU - Chen, Chien Han. AU - Lee, Yungling Leo. N1 - Funding Information: This study was supported by grants #98-2314-B-002-138-MY3 and #101-2314-B-532-002-MY3 from Taiwan National Science Council . PY - 2013/1/1. Y1 - 2013/1/1. N2 - Aims: The joint effect of obesity and asthma on hyperlipidemia has never been explored. We aim to examine (1) the association of dyslipidemia and asthma, (2) the interaction effect of asthma and obesity on hyperlipidemia, and (3) whether a gender difference existed in the above relationships. Methods: Between 2009 and 2010, 10- to 15-year-old children were recruited from 7 schools and 2 hospitals in Northern Taiwan. The population consisted of 237 asthmatic children and 225 non-asthmatic controls, and was further divided into four groups: ...

My answer: Asthma is a disease of chronic (its always there) inflammation in the air passages of your lungs. This makes your lungs hyper sensitive, or over reactive, to certain substances, such as cockroach urine, dust mites, animal dander, molds, fungus, strong smells, smoke, etc. These would be your asthma triggers. When exposed to your triggers this may irritate this inflammation, thus making it worse. The result causes an acute asthma attack. During an asthma attack the muscles lining the air passages spasm and this causes the air passages to become narrow. This results in airway obstruction, whereby air gets trapped in the lungs and cant get out. The inflamed air passages also produce excessive secretions, and this can exacerbate the problem. The end result is wheezing as air passes through the obstruction, chest tightness, coughing, and shortness of breath. An acute asthma (its happening now) attack can be treated with asthma rescue medicine like albuterol and levalbuterol, and ...

OBJECTIVE: To examine the incidence of occupational asthma in the seven aluminum smelters of Australia and New Zealand from 1991 to 2006.. METHODS: Incidence and exposure data were collected by survey from the smelters prospectively during the study period.. RESULTS: The incidence of occupational asthma across all smelters combined was highest in 1992 at 9.46/1,000/year, declining to 0.36/1,000/year in 2006; a 96.2% reduction. The incidence of occupational asthma was correlated with geometric mean total fluoride concentration, measured as personal samples from employees undertaking anode changing (r(s) = 0.497, P , 0.001).. CONCLUSIONS: The control of exposures, respiratory protection and pre-placement medical assessments undertaken during the study period seem to have contributed to the substantial decline in occupational asthma incidence.. ...

Asthma control in adolescents: role of leukotriene inhibitors Stavroula Giavi, Nikolaos G PapadopoulosAllergy Department, Second Pediatric Clinic, University of Athens, Athens, GreeceAbstract: Asthma is a chronic inflammatory disease of the airways and is a big burden worldwide. It affects both children and adults, but it is insufficiently studied in adolescents, although this age group has important peculiarities and is challenging to treat, due to, but not exclusively because of, lack of adherence to treatment instructions. Evidence-based guidelines for the treatment of asthma targeting specifically adolescents are lacking, due to the fact that most studies are conducted either on children or in adults. Exercise-induced asthma occurs commonly in adolescents, leading to impaired physical activity. This review describes current treatment options for asthma in adolescents, focusing on leukotriene receptor antagonists, both as a monotherapy and as an add-on therapy for optimal asthma control.Keywords:

Two new studies of patients with difficult-to-control asthma show that the eczema drug dupilumab alleviates asthma symptoms and improves patients ability to breathe better than standard therapies. Dupilumab, an injectable anti-inflammatory drug, was approved in 2017 by the Food and Drug Administration as a treatment for eczema, a chronic skin disease.. Researchers at Washington University School of Medicine in St. Louis and other institutions conducted the studies and were scheduled to present the results May 20 and 21 at the 2018 American Thoracic Society Conference in San Diego. The studies also will be published online May 21 in The New England Journal of Medicine.. The more than 2,000 patients enrolled in the studies suffered from moderate to severe asthma. All used standard asthma inhalers, and some also took oral steroids to control their severe asthma symptoms.. In one study, the rate of asthma exacerbations was almost cut in half for those taking dupilumab compared with those taking a ...

In this report, AFO prevalence is higher when the PREO criterion is applied. About 8.5% of all subjects had PREO-POSTN, whereas 3% had a PREN-POSTO spirometric pattern. In adjusted analysis, we found no difference in COPD features and outcomes between PREO-POSTN and PREN-POSTO subjects. Although both prebronchodilator and postbronchodilator spirometry are associated with chronic bronchitis, dyspnoea, exercise capacity and COPD radiographic findings, models that include postbronchodilator spirometric measures perform better than those with prebronchodilator measures to predict those outcomes. The predictive value of prebronchodilator and postbronchodilator spirometries are relatively similar for respiratory exacerbations, change in FEV1 and dyspnoea from phase 1 to phase 2 visits. Both prebronchodilator and postbronchodilator spirometry are associated with mortality, but models that include postbronchodilator spirometric measures perform better than models with prebronchodilator spirometry. About ...

Background Asthma prevalence has declined in some countries over the past 10 years. Most reports have been based on population surveys conducted at two points of time in a given location. Comparisons across countries and time periods can be limited by differences in study methodology or disease diagnostics in different communities. Here, we examined trends in asthma prevalence using serial annual data and further examine the importance of country of birth.. Methods The source population has children aged 4-6 commencing school in the Australian Capital Territory from 2000 to 2005 inclusive. Over 80% of these children and their families completed a health questionnaire on asthma, other atopic disease and respiratory symptoms using some questions from the International Study of Asthma and Allergies in Childhood (n = 22 882). Current asthma has been previously validated against physician assessment in this setting.. Results The prevalence of current asthma declined (P , 0.001) but eczema ever ...

I always tell people that asthma is like a drama queen. (Those of you with teenagers know all about drama and over reacting.) With asthma, your body over reacts to normal every day things - you know, like stress, animals, grass, trees, flowers, perfume, cleaning supplies, air pollution (these are asthma triggers - they trigger an asthma attack). Normal People can be around these things without thinking twice. But someone with asthma gets around any of those asthma triggers and our lungs over react and swell, make mucus, and the bands around the bronchial tubes tighten. ...

BACKGROUND: The prevalence of exercise-induced bronchoconstriction among British children by ethnicity has not been studied. METHODS: Peak expiratory flow rate (PEFR) was measured before and after an exercise challenge test using a cycle ergometer in 593 nine year olds from Scottish and inner city English schools. Logistic regression analysis was carried out to assess the association between changes in PEFR with exercise by reported asthma, ethnicity, and sex. RESULTS: The probability of exercise-induced bronchoconstriction was greater among the asthmatics than in either the children without asthma attacks or wheeze, or in the children with only wheeze (p , 0.01). Asian children were 3.6 times more likely to have exercise-induced bronchoconstriction than white inner city children, and also were more likely to have exercise-induced bronchoconstriction than those from the other ethnic groups (p , 0.01). CONCLUSION: Exercise challenge can assess the prevalence of asthma in the community and detect ...

TY - JOUR. T1 - Asthma exacerbations in African Americans treated for 1 year with combination fluticasone propionate and salmeterol or fluticasone propionate alone. AU - Bailey, William. AU - Castro, Mario. AU - Matz, Jonathan. AU - White, Martha. AU - Dransfield, Mark. AU - Yancey, Steve. AU - Ortega, Hector. PY - 2008/6/1. Y1 - 2008/6/1. N2 - Objective: This long-term prospective study was conducted in African Americans with persistent asthma to examine the safety and effectiveness of the combination of the inhaled corticosteroid, fluticasone propionate (FP), and the long-acting beta-agonist, salmeterol, compared with FP alone. Research and design methods: This was a randomized, double-blind, parallel group, multi-center trial in adolescent and adult subjects ≥12 years of age symptomatic on a low dose of an inhaled corticosteroid (ICS). The study consisted of a 2-week screening period on low dose ICS; a 4-week open-label FP 250 mcg twice daily (BID) run-in; a 52-week double-blind period ...

Data & statistics on Asthma hospitalisations by Health Area and sex: Asthma hospitalisations by Health Area and sex, NSW 2006-07, Data on avoidable hospitalizations by gender and condition. Pneumonia and heart failure account for the largest proportion of avoidable hospitalizations for both sexes. For all conditions except appendix, gangrene, and ulcers, females have higher rates of avoidable conditions than males. For hypertension, asthma, hypokalemia, and pyelonephritis, the difference in female and male rates of avoidable ..., Childhood (|5 years) Asthma Hospitalization by Area and Sex...

Figure 1: Diagram of the bronchial tubes and lungs.. Severity of Asthma Attacks. Asthma attacks can be mild and infrequent, responding to an inhaled bronchodilator. They can also be frequent and severe enough to be life-threatening. A diagnosis of asthma alone does not mean you are entitled to Social Security disability benefits. When properly treated, people with asthma have participated in the Olympics, professional sports, amateur sports, and school-related sports without danger or difficulty.. Treatment for Asthma. For years researchers have studied genetic, environmental, and immunological factors that may play a role in asthma. Despite gaps in knowledge, they have made considerable progress in treatment. Both the inflammation and the bronchial narrowing must be controlled for effective treatment. Patients with chronic asthma who receive inhaled steroids to reduce inflammation along with bronchodilators to relax tight muscles do better than those who receive bronchodilators alone. Many ...

BACKGROUND: The cysteinyl leukotrienes (LTC4, LTD4 and LTE4) have been implicated in the pathogenesis of allergen-induced airway responses. The effects of pretreatment with BAYx 1005, an inhibitor of leukotriene biosynthesis via antagonism of 5-lipoxygenase activating protein, on allergen-induced early and late asthmatic responses has been evaluated. METHODS: Eight atopic subjects with mild asthma participated in a two period, double blind, placebo controlled, cross-over trial. Subjects were selected on the basis of a forced expiratory volume in one second (FEV1) of , 70% predicted, a methacholine provocative concentration causing a 20% fall in FEV1 (PC20) of , 32 mg/ ml, a documented allergen-induced early response (EAR, , 15% fall in FEV1 0-1 hour after allergen inhalation) and late response (LAR, , 15% fall in FEV1 3-7 hours after allergen inhalation), and allergen-induced airway hyperresponsiveness (at least a doubling dose reduction in the methacholine PC20 30 hours after allergen ...

Part of $1.2 Million Awarded Nationwide LOS ANGELES - The U.S. Environmental Protection Agency recently awarded $39,327 to the American Lung Association of California (ALA CA) to improve air quality as well as student asthma self-management skills in low-income schools in San Diego, Calif. With this funding, ALA CA will provide indoor environmental asthma trigger training for more than 300 children with asthma in 20 schools that bear the greatest asthma burden in San Diego. The funding will also help schools in San Diego establish indoor air quality management programs consistent with the practices of the EPAs Indoor Air Quality Tools for Schools program. EPA is proud to be working with our awardees across the nation to improve the air we breathe at school, work and home, said Gina McCarthy, assistant administrator for EPAs Office of Air and Radiation. American communities face serious health and environmental challenges from air pollution. This effort gives us an opportunity to improve ...

It is generally surmised that community stressors have an incubating effect for a variety of diagnoses on maternal and child health. This is of public health significance, as children of mothers facing long-term distress were found to have a 60% higher risk for asthma diagnosis at age 7 in Manitoba, Canada. Our objective was to determine the association of community stressors with childhood asthma prevalence in Winnipeg, Canada from participants who completed the Study of Asthma, Genes and the Environment (SAGE) survey administered in 2002-2003 to a birth cohort from 1995. Measures of community socioeconomic makeup and community disorder with rank ordinalized by quintile at the census tract level were obtained from the 1996 Canada Census. Crime data (annual incidence per 10,000 persons) by neighbourhood profile for 2001 was provided by the Winnipeg Police Service. Dichotomous caregiver report of child asthma along with other indicators from the geocoded SAGE survey allowed linkage to 23 neighbourhood

Flushing, New York - New York Hospital Queens announces the relocation of its Pediatric Asthma Center to a new and larger facility in Fresh Meadows. The center, previously located on Booth Memorial Avenue, is now located at 59-16 174th Street, adjacent to several other specialty clinics operated by the hospital.. Patients and families can contact the center for appointments at (718) 670-1920. The new location has ample space for parking and is accessible via several bus routes. A hotline is available at (800-) 926-5182 for night or weekend emergencies.. Along with this new location, the Pediatric Asthma Center - the longest-running center of its kind in Queens - also provides services at The Jackson Heights Family Health Center at 73-15 Northern Boulevard. The NYHQ Mobile Asthma Unit has been renovated and can travel upon request to provide services at other locations, such as community health fairs.. Moving our Pediatric Asthma Center to Fresh Meadows enhances our ability to provide the ...

Updated guidelines for asthma management include recommendations for preventing and treating thunderstorm asthma.. The update includes important information on the clinical interrelationship between asthma and allergic rhinitis, and guidance for diagnosing and managing patients with asthma-COPD overlap.. Highlights include:. Thunderstorm-triggered asthma:. ...

Your Asthma Action Plan includes information about your symptoms and medicines. It also includes instructions about managing your asthma symptoms and when to call your healthcare provider.

She said In this study we see that childhood eczema, particularly when hay fever also occurs, is a very strong predictor of who will suffer from allergic asthma in adult life.. The implications of this study are that prevention and rigorous treatment of childhood eczema and hay fever may prevent the persistence and development of asthma.. She also said this is the first study to distinguish between allergic and non-allergic asthma and their occurrence after childhood eczema and hay fever, as part of a sequence of allergic illnesses dubbed the atopic march. Associate Professor Shyamali Dharmage, principal investigator of the TAHS and from the University of Melbournes School of Population Health said currently few interventions are trialled to halt this march from childhood allergies to asthma.. If successful strategies to stop the atopic march are identified, this could ultimately save lives and health care costs related to asthma management and treatment.. The researchers estimate ...

Dr. Reckeweg R76 drop is a homeopathic medicine that used for the treatment of Asthma in Child & Adults. If you or your child is suffering from asthma, you can take homeopathy R76 medicines and cure Asthma disease.

in Thorax (2010), 65(12), 1039-1044. Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that ... [more ▼]. Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that identifies a sputum eosinophil count ,/=3% in an unselected population of patients with asthma has been poorly studied. Methods This retrospective study was conducted in 295 patients with asthma aged 15-84 years recruited from the asthma clinic of University Hospital of Liege. Receiver-operating characteristic (ROC) curve and logistic regression analysis were used to assess the relationship between sputum eosinophil count and FeNO, taking into account covariates such as inhaled corticosteroids (ICS), smoking, atopy, age and sex. Results Derived from ...