The overall goal of the Severe Asthma Research Program (SARP) is to develop a new paradigm for the understanding of severe asthma and its sub-phenotypes, in chi...
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Data & statistics on Current Asthma Status by Health Care Utilization Colorado Adults BRFSS: Current Asthma Status by Health Care Utilization: Colorado Adults, BRFSS 2000, To the right breaks down the prevalence of COPD among Colorado adults by age, race/ethnicity, sex, employment status, education level, income, marital status, smoking status, and asthma history., Urgent care visits: Percent of adults currently with asthma who had at least one urgent care visit for asthma with their provider in the past 12 months by State, District of Columbia and U.S. Territory, 2003...
The Asthma USA survey showed that uncontrolled asthma had significant medical consequences. Adults with uncontrolled asthma were more prone to need treatment with oral corticosteroids, visit the emergency room, or be hospitalized, compared with patients with well-controlled asthma.. Children with uncontrolled asthma also were in the same situation. Earlier studies have shown that uncontrolled asthma can put patients at risk for increased asthma symptoms, sudden asthma attacks, hospitalization, and even death.. The survey included >81,500 households that were assessed using the Asthma Control Test (ACT). Of the >10,000 adults with self-reported asthma taking the ACT, 41% had a score of 19 or less, which indicates uncontrolled asthma. The survey also examined scores from the Childhood Asthma Control Test and ACT in >3000 children respondents between the ages of 4 and 17. The results indicated that 31% of the children with asthma between the ages of 4 and 11 and 25% of those between the ages of 12 ...
Updated guidelines and new treatments for asthma have become available since the last major survey of asthma management in the United States was completed ∼11 years ago. The Asthma Insight and Management (AIM) survey was conducted to assess the current status of asthma burden in the United States. A geographically stratified screening of 60,682 households provided a national sample of 2500 patients with current asthma (2186 adults aged ≥18 years; 314 adolescents aged 12‐17 years). A national sample of 1004 adults without current asthma was interviewed for comparison with the adult asthma population, and 309 asthma health care providers were surveyed for their opinions about the burden of asthma. Asthma prevalence in the United States was estimated at 8%. Twice as many adult asthma patients rated their health as "only fair," "poor," or "very poor," or experienced limitations in activity because of health problems, compared with the general population. Asthma also frequently caused negative ...
Asthma is a prevalent chronic respiratory disease and major cause of morbidity in the United States (1). However, with appropriate medication, medical care, and self-management, most asthma symptoms are preventable (2). Recent evidence indicates that asthma self-management education is effective in improving outcomes of chronic asthma (3). Guidelines issued by the National Asthma Education and Prevention Program (NAEPP) specify essential components of asthma management, including patient education, objective monitoring of symptoms, and avoiding asthma triggers (3). Healthy People 2010 objectives include increasing the proportion of persons with asthma who receive formal patient education from 8% to 30% (objective 24-6) and who receive care according to NAEPP guidelines (objective 24-7) (4,5). The National Health Interview Survey (NHIS) routinely includes questions that assess asthma status. In 2003, the survey included a series of questions designed to reflect clinical best practices for asthma ...
TY - JOUR. T1 - The Role of the Six-minute Walk Test, Pulmonary Function Test, and Asthma Control Test in Asthmatic Patients-a Preliminary Report. AU - Chen, Shiau-Yee. AU - Hsu, Han Lin. AU - Lin, Jiu Jenq. AU - 余, 明治(Ming-Chi Yu). AU - 江, 玲玲(Ling-Ling Chiang). AU - 李, 俊年(Chun-Nie Lee). PY - 2010. Y1 - 2010. N2 - Purpose: Asthma control is the main concern for related professionals when approaching asthmatic patients. In this study, we selected three different tools to understand asthma control status in patients with asthma.Methods: Twenty-six patients with asthma were recruited in the study. These patients underwent pulmonary function testing with spirometry and the six-minute walk test, and completed an asthma control questionnaire (Asthma Control Test, ACT). In statistical analysis, the Spearman rank correlation and Pearson correlation coefficient were used for correlation between measured variables. For explanation, potential prediction variables were entered into a ...
The phenotypic features of asthma differ by severity and with advancing age. With advancing age, patients with severe asthma are more obese, have greater airflow limitation, less allergen sensitization, and variable type 2 inflammation. Novel mechanisms besides type 2 inflammatory pathways may infor …
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By Jaclyn Chasse N.D.. Over 22 million Americans have asthma and it is one of the most common pediatric chronic diseases, affecting about 6 million children. Asthma is a condition characterized by cough, difficulty breathing, wheezing and chest tightness. Asthma has several underlying pathological mechanisms including bronchoconstriction, bronchial hyperreactivity, and underlying inflammation and airway edema.. The National Asthma Education and Prevention Program (NAEPP) first published guidelines for care in 1991 and published the most recent update in 2007. One of the key clinical activities recommended by the NAEPP is the development of a written asthma action plan in partnership with the patient. An asthma action plan is a written tool which outlines appropriate care for an asthma patient. The stoplight tool is on example of a written asthma action plan that categorizes severity of asthma into a red, yellow, or green zone. Each zone corresponds with a different stage of asthma and outlines ...
BackgroundMany patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women. MethodsWe analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses. ResultsDuring a median follow-up of 10years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic ...
As co-Editors in Chief (and Professor Canonica as President of Interasma), it is our pleasure to welcome our colleagues to this first issue of the journal Asthma Research and Practice (ARP) [1]. This will be an open-access online journal, and thus easily accessible to a large audience. The aims and scope of ARP will be to publish original research articles and state of the art reviews focusing on risk factors, diagnosis and management of asthma at all ages. Since asthma is a disease that comprises diverse endotypes and is often accompanied by co-morbidities, we expect and welcome manuscripts on topics such as "obese asthma", exercise-induced asthma, asthma-COPD overlap syndrome, occupational asthma, and others [2, 3]. Although existing journals in fields as diverse as paediatrics, internal medicine, allergy and pulmonology include articles on asthma, we believe that a journal entirely dedicated to asthma is both valuable and necessary. Moreover, we are committed to have a section devoted ...
We have previously shown that atopic mechanisms may account for, at most, "only" 40% of cases of asthma in the general population.4 Interestingly, in this review we have shown that, at most, "only" 50% of all asthma cases are attributable to eosinophilic airway inflammation. Thus, evidence from studies of eosinophilia and asthma is consistent with that from studies of atopy and asthma: in both instances, at most about 50% of asthma cases appear to be due to "allergic" mechanisms (whether these are defined in terms of atopy or in terms of eosinophilia). This further adds to the evidence that allergic mechanisms may not be the only and/or necessarily the most important underlying mechanism for asthma. Non-eosinophilic asthma is associated with neutrophilic responses not only in severe asthmatics but also in those with moderate and mild asthma, and we thus hypothesise that a major proportion of asthma is based on neutrophilic airway inflammation. Environmental exposure to bacterial endotoxin, ...
Mild and Severe Asthma May Be 2 Diseases The authors of a study reported recently in the European Respiratory Journal have concluded that severe asthma and mild asthma may be different conditions with different inflammatory processes. The study, conducted by scientists across Europe, evaluated 321 patients, 158 with mild-to-moderate asthma and 163 with severe asthma. The results of the study showed that both groups had very different levels of key chemicals in their blood. Also, whereas more men suffered from asthma, women were 4 times as likely to suffer from severe asthma. Individuals with mild-to-moderate asthma were able to control their symptoms with low doses of inhaled corticosteroids. Very few with severe asthma, however, were able to have their symptoms treated despite being treated with heavier doses of drugs. ...
The Particulars: Research shows that chronic asthma and cardiovascular disease (CVD) share a common inflammatory pathophysiology. However, few studies have explored the potential association between persistent asthma-defined as requiring daily controller medications-and an increased risk of CVD.. Data Breakdown: Researchers compared the rates of CVD over 9 years among patients with persistent asthma, intermittent asthma, or no asthma for a study. Among those with persistent asthma, 84.1% were alive and free from CVD, compared with a 91.1% rate for those with intermittent asthma and a 90.2% rate for those without asthma. Patients with persistent asthma had about a 60.0% higher risk of CVD events that those without asthma.. Take Home Pearl: There appears to be a strong association between persistent asthma and risk for CVD. ...
Severe asthma is typically characterized by chronic airway inflammation that is refractory to corticosteroids and associated with excess morbidity. Patients were recruited into the National Heart, Lung, and Blood Institute-sponsored Severe Asthma Research Program and comprehensively phenotyped by bronchoscopy. Bronchoalveolar lavage (BAL) cells were analyzed by flow cytometry. Compared with healthy individuals (n = 21), patients with asthma (n = 53) had fewer BAL natural killer (NK) cells. Patients with severe asthma (n = 29) had a marked increase in the ratios of CD4+ T cells to NK cells and neutrophils to NK cells. BAL NK cells in severe asthma were skewed toward the cytotoxic CD56dim subset, with significantly increased BAL fluid levels of the cytotoxic mediator granzyme A. The numbers of BAL CD56dim NK cells and CCR6−CCR4− T helper 1-enriched CD4+ T cells correlated inversely with lung function [forced expiratory volume in 1 s (FEV1) % predicted] in asthma. Relative to cells from healthy ...
A stranger would never guess my friend Catrina has asthma. She plays three varsity sports, sings along to entire musicals without losing her breath, and overall leads an active, nonstop life. Because of the incredible advancements in asthma treatment, Catrina seems practically indistinguishable from someone without asthma. Even I have never seen her reach for her inhaler. It is only because of our close friendship that I know she takes medicine to control her asthma and frequently visits an allergist. How has asthma treatment come so far? The use of animals in asthma research has lead to many groundbreaking discoveries that have benefited asthma sufferers like Catrina. Early asthma studies relied on animal research, and so does the current research that develops the kind of new medicines that Catrina uses today.. Asthma is defined by the National Institutes of Health as a "chronic lung disease that inflames and narrows the airways", with symptoms of "recurring periods of wheezing, tightness, ...
TY - JOUR. T1 - Management of asthma exacerbations. AU - Chestnutt, Mark. PY - 2002/1/1. Y1 - 2002/1/1. N2 - The 1997 Expert Panel Report 2 from the National Asthma Education and Prevention Program* details principles and goals for managing asthma exacerbations, based on scientific literature and the opinion of the panel. The panels recommendations are summarized here, along with approaches to the evaluation and management of patients with asthma exacerbations. Methods to assess and classify the severity of asthma exacerbations are discussed, and treatment objectives for mild, moderate, and severe exacerbations are presented, along with a discussion of postinfectious acute airway hyperresponsiveness. A review of pharmacologic agents used in the treatment of asthma exacerbations is also included. Key points in the management of asthma exacerbations include the notion that early treatment is the best strategy for management. Important elements of early treatment include recognition of early signs ...
... The Community Asthma Program provides free asthma self-management education and support for children and young people with asthma and their families.. The program is aimed at people who frequently attend an Emergency Department for help with asthma, are at risk of attending or have complex psychosocial needs impacting on their ability to self-manage their asthma.. Families entering the program receive one-on-one help and support from a qualified health professional with advanced skills in asthma and respiratory education.. Click on the links below for further information: ...
Accordingly, the new update of the Global Initiative for Asthma (GINA) guidelines 2006 is based on the control of the disease and attempts to quantify and graduate the level of control by using a classification of asthmatic subjects into controlled,partly controlled and uncontrolled groups.. Achieving and maintaining optimal asthma control is a major goal of asthma management. Although the results of clinical trials advocate that asthma control can be reached in most patients, there is evidence that many subjects with asthma have poorly controlled disease and that there is a significant gap between the treatment goals and the current level of asthma control achieved in the general population.. The aim of this study is to assess the prevalence of uncontrolled and partly controlled asthma in Italy using a patient-based tool such as Asthma Control Test. ...
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Asthma Surveillance Abstract: Asthma Surveillance (Asthma GIS Maps) The Burden of Asthma in Connecticut 2012 Surveillance Report Asthma is a chronic disease of the respiratory system that is characterized by reversible obstruction of the airways and airway hyper-responsiveness to a variety of stimuli. Left uncontrolled or poorly-managed, asthma can lead to emergency department visits, hospitalization, or death. In 2010, 18.7 million adults and 7 million children in the United States had asthma. Asthma prevalence in Connecticut adults and children has been higher than national prevalence rates since the year 2000. In Connecticut, the populations disproportionately affected by asthma are: children, females, Hispanics, non-Hispanic Blacks, and residents of CTs five largest cities.Custom Download Select specific sections of The Burden of Asthma in ConnecticutFull Version Download the complete version of The Burden of Asthma in Connecticut Updated Report Tables (2016): Table F-1: Asthma Hospitalization
Results. A total of 4.8% of children had atopic asthma, 1.9% had nonatopic asthma, 3.4% had resolved asthma, and 4.3% had frequent respiratory symptoms. Mean BMI was higher among children with nonatopic asthma, whereas prenatal maternal smoking was a risk factor for resolved asthma. Atopic and nonatopic asthma were similar for most measures of asthma severity (eg, medication use and lung function), and relatively few children in either group were receiving inhaled corticosteroids (5%-10%). Patients with resolved asthma had fewer symptoms but lung-function impairment similar to that seen with current asthma, whereas children with frequent respiratory symptoms but no asthma diagnosis had normal lung function. ...
If you or your child has asthma that requires daily treatment, it is important to have an asthma action plan. An asthma action plan is a written plan that tells you what asthma medicine to take every day and how to treat an asthma attack. It can help you make quick decisions in case you are not able to think clearly during an attack.. An asthma action plan usually includes:. ...
TY - JOUR. T1 - Measures of asthma control. AU - Bime, Christian. AU - Nguyen, Jessica. AU - Wise, Robert A.. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Purpose of Review: Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research. Recent Findings: Several questionnaires for assessing asthma control have been extensively validated in adults. In children, validation data are less extensive. Considerable overlap exists between asthma control measures and measures of asthma-specific quality of life. Asthma-specific quality-of-life questionnaires have been used as primary outcome measures in major clinical trials evaluating asthma therapy. Biomarkers that reflect eosinophilic inflammation of the airways are used ...
About Severe Asthma. Asthma affects 315 million individuals worldwide, and up to 10% of asthma patients have severe asthma, which may be uncontrolled despite high doses of standard-of-care asthma controller medicines and can require the use of chronic oral corticosteroids (OCS).. Severe, uncontrolled asthma is debilitating and potentially fatal with patients experiencing frequent exacerbations and significant limitations on lung function and quality of life. Severe, uncontrolled asthma has an eight times higher risk of mortality than severe asthma.. Severe, uncontrolled asthma can lead to a dependence on OCS, with systemic steroid exposure potentially leading to serious short- and long-term adverse effects, including weight gain, diabetes, osteoporosis, glaucoma, anxiety, depression, cardiovascular disease and immunosuppression. There is also a significant physical and socio-economic burden of severe, uncontrolled asthma with these patients accounting for 50% of asthma-related costs.. About the ...
KLING, S et al. Guideline for the management of acute asthma in children: 2013 update - Part 3: March 2013. SAMJ, S. Afr. med. j. [online]. 2013, vol.103, n.3, pp.199-207. ISSN 2078-5135.. BACKGROUND: Acute asthma exacerbations remain a common cause of hospitalisation and healthcare utilisation in South African children. AIM: To update the South African paediatric acute asthma guidelines according to current evidence, and produce separate recommendations for children above and below 2 years of age. METHODS: A working group of the South African Childhood Asthma Group was established to review the published literature on acute asthma in children from 2000 to 2012, and to revise the South African guidelines accordingly. RECOMMENDATIONS: Short-acting inhaled bronchodilators remain the first-line treatment of acute asthma. A metered dose inhaler with spacer is preferable to nebulisation for bronchodilator therapy to treat mild to moderate asthma. Two to four puffs of a short-acting bronchodilator ...
Asthma symptoms were recorded by the patient each morning and evening in the asthma daily diary. Symptoms were recorded using a scale of 0-3, where 0 indicates no asthma symptoms. The daily asthma symptom total score was calculated by taking the sum of the daytime score recorded in the evening and the nighttime score recorded the following morning. The weekly total asthma score was averaged from the daily scores over a 7 day period, with score ranging from 0 to 6, where 0 indicates no asthma symptoms. The changes from baseline of weekly total asthma score are compared between benralizumab 30 mg Q4W and placebo by using the mixed-effect model repeated measures (MMRM) with baseline blood eosinophil count (≥300 cells/μL or ,300 cells/μL), protocol specified visit, region (Europe or North America) and treatment*visit interaction as fixed effects and baseline total asthma score as a covariate.. Changes at Week 12 were calculated based on patients with both baseline and Week 12. ...
Based on the modified GINA criteria, of the 397 children in the sample, 143 (36%) had intermittent asthma; 160 (40%) had mild persistent asthma; 51 (12.8%) had moderate persistent asthma; and 43 (10.8%) had severe persistent asthma. In 60 children, occasional limitation of daily activities was the indicator of greatest severity. Taking into account that responses to the remaining questions were not related to more severe asthma, a decision for more conservative categorization was made, and these children were classified as having mild persistent asthma. Based on the ISAAC questionnaire, 90 of the 397 children (22.3%) provided positive responses to questions assessing symptom severity, whereas 307 (77.3%) replied in the negative.. Comparison of both asthma severity criteria according to data from the second survey (Table 2) shows that, the greater the severity of the disease according to GINA criteria, the greater the proportion of children with more severe symptoms as assessed by ISAAC. No ...
The University of Sydney in Australia is currently performing asthma research and is trying to stop the destructive cells responsible for the inflammatory response from being produced. These cells are stimulated by chemical messengers called cytokines and current medications, for example steroids which help to reduce the concentration of cytokines and stop the inflammatory response.. Steroids also have an effect on a number of other tissues in the body and are known to produce side effects. Asthma research at the university is undergoing on how the cytokines are produced and how they can stop production and also inflammatory response.. Woolcock Institute of Medical Research is conducting an asthma research on the long-term effects of asthmatic episodes on the lining of the airways and how the inflammatory response can affect and how current medications work.. They are trying to develop a non-invasive method that will allow them to determine the degree of scarring and how this affects the ...
Lung function test: Lung function test is an asthma test used to determine if there is any progress in your breathing following the inhalation of a bronchodilator. If there is fifteen percent improvement, then asthma is a possible diagnosis.. Spirometry: Spirometry is the lung function test that can be carried at asthma clinic. It is used to measure how much and how quickly you can move air out of your lungs. You have to inhale and exhale deeply and seal your lips around the mouthpiece and blow forcefully as long as possible. The information is collected by the spirometer and can be printed out on a chart called spirogram.. Skin prick test: Skin prick test is an asthma test used to identify any allergens which you may be sensitive and which may trigger asthma attack. Some small amounts of allergens are injected into your skin of the forearm and the area is monitored for a reaction.. After monitoring for fifteen minutes, if there is no visible swelling, then it may that you dont have asthma or ...
Though exercise-induced bronchoconstriction is common among asthmatics, physical activity (PA) seems important in asthma management. Still, various studies point at avoidance of sports and certain daily life activities like walking stairs, even by patients with mild symptoms. We aimed to compare physical activity levels between healthy subjects and asthmatics with controlled and uncontrolled disease. Data on asthma and PA were drawn from the Portuguese National Asthma Survey. The short telephone version of the International Physical Activity Questionnaire (IPAQ) was used to measure PA levels. Current asthma was defined as self-reported asthma and at least one of these criteria: one or more asthma symptoms in the last twelve months, currently taking asthma medication or an asthma medical appointment in the previous twelve months. Controlled asthma was defined as a CARAT global score | 24 or a CARAT second factor score ≤ 16. Healthy subjects were defined as individuals without atopy, heart disease or
Asthma Action Plan. You and your doctor write an Asthma Action Plan together. It is a written plan that will help you stay away from triggers and take medicine to control your asthma symptoms. Learn more about an Asthma Action Plan. Always keep a copy with you.. Asthma Control Test:. The Asthma Control Test (ACT) has questions for a person with asthma. Take the ACT and see if your asthma is under control. Share the results with your doctor. Page Updated: 12/7/2017 ...
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Little is known about asthma in the elderly as most studies of this condition have not included this patient group. It is unclear whether leukotriene antagonists benefit older asthmatics. We studied the effect of adding montelukast to the asthma treatment of elderly subjects. Twenty-five subjects 65 years old and older with asthma were evaluated at week 0, 1, 5, 9, 13, and 17. Each subject received montelukast 10 mg and placebo each for 8 weeks in a cross-over design. Montelukast for 4 or 8 weeks did not significantly affect ACT, daily symptom scores, number of puffs of albuterol, spirometric values, peripheral blood eosinophils, or serum IgE vs. baseline or placebo. Similar results were obtained when analyzing subgroups of patients with lower ACT, lower FEV1, and higher eosinophils. In this study of elderly asthmatics, montelukast had no effect on asthma symptoms, number of puffs of albuterol, spirometric values, peripheral blood eosinophils or serum IgE. These results will require confirmation in
Jason Lang, MD, MPH. Summary. BACKGROUND: Poorly controlled asthma especially in children remains a major public health problem. Many children with poor asthma control experience gastroesophageal reflux (GERD). The effect of mild GERD on asthma remains controversial despite studies involving proton-pump inhibitors (PPIs) assessing their effect on asthma.. GAP: Past inconsistent findings regarding the effect of PPIs on asthma control may have resulted from ineffective dosing strategies of proton-pump inhibitors employed in these studies. Drug levels and efficacy vary widely in the population and depend on genetics. Dosing in children which adjusts for the gene CYP2C19 may improve efficacy and reduce side-effects leading to improved asthma control.. HYPOTHESES:. #1: Our group hypothesizes that genotype-tailored lansoprazole dosing will reduce asthma symptoms in children with mild symptoms of GERD compared to placebo.. #2: CYP2C19 and ABCB1 genetic variants influence the pharmacokinetics (drug ...
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Rationale. Managing chronic paediatric asthma includes optimizing both asthma control and asthma-specific quality of life (QoL). However, it is unknown to what extent asthma-specific QoL is related to asthma control or other clinical asthma characteristics over time.. Objectives. To determine in children, longitudinally:. 1) the association between asthma control and disease specific QoL;. 2) the relationship between clinical asthma characteristics and disease specific QoL.. Methods. A prospective cohort study in 96 asthmatic children was carried out over one year. During two monthly regular visits, disease specific QoL, asthma control, dynamic lung function indices, fractional exhaled nitric oxide, occurrence of exacerbations, and use of rescue medication were assessed. Association between asthma clinical characteristics and asthma-specific QoL was analysed using linear mixed models.. Results. Asthma control improvement was associated with an increase in the PAQLQ total score (p-value ...
Using the candidate gene approach (discussed earlier in this chapter), many genes have been associated with asthma or asthma-related traits such as allergy and high concentrations of immunoglobulin E (IgE) in serum (table 2). Not all of these suspected asthma susceptibility genes have been replicated in multiple independent studies. One group of (allergic) asthma susceptibility genes is involved in innate immunity responses, encompassing pattern-recognition receptors, immunoregulatory cytokines and molecules involved in antigen presentation. A second group of asthma susceptibility genes are key players in T-helper type 2 (Th2)-cell differentiation and Th2- cell effector function. Th2 cells are T-lymphocytes that drive the production of allergic immunoglobulins (IgE) and the chronic airway inflammation in (allergic) asthma.. Linkage studies in families have discovered several novel asthma susceptibility genes that are expressed in epithelial cells and/or smooth muscle cells in the airways (table ...
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Why are asthma cases growing at a rapid rate? Here are 7 key reasons, plus tips for respiratory therapists to help patients control their asthma triggers.
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About Severe Asthma. Asthma affects 315 million individuals worldwide, and up to 10% of asthma patients have severe asthma which may be uncontrolled despite high doses of standard-of-care asthma controller medicines and can require the use of chronic OCS.. Severe, uncontrolled asthma is debilitating and potentially fatal with patients experiencing frequent exacerbations and significant limitations on lung function and quality of life. Severe, uncontrolled asthma has higher risk of mortality than severe asthma.. Severe, uncontrolled asthma can lead to a dependence on OCS, with systemic steroid exposure potentially leading to serious short- and long-term adverse effects, including weight gain, diabetes, osteoporosis, glaucoma, anxiety, depression, cardiovascular disease and immunosuppression. There is also a significant physical and socio-economic burden of severe, uncontrolled asthma with these patients accounting for 50% of asthma-related costs.. About Fasenra (benralizumab). Fasenra is a ...
The Global Initiative for Asthma (GINA) today is launching a new program to recognize individuals who are helping to improve asthma awareness, diagnosis, and care in countries around the world.. The GINA Ambassador program will highlight individuals who are involved in taking care of asthma patients in the clinic, improving public policy around asthma care, implementing GINA management strategies in their local community, developing asthma education materials, building multidisciplinary asthma care teams, and organizing World Asthma Day activities.. World Asthma Day is an annual awareness - raising event held today, the first Tuesday in May, and organized by GINA. The GINA Ambassador program is being launched on World Asthma Day because it reflects the events positive theme, "You Can Control Your Asthma.". "GINAs development of an evidence - based asthma management strategy is only one step in improving asthma care around the world," says Dr. Mark FitzGerald, Professor at the University of ...
Asthma is caused by inflammation of the airways. These are the small tubes, called bronchi, which carry air in and out of the lungs. If you have asthma, the bronchi will be inflamed and more sensitive than normal.. Please make it clear to reception staff that you are asthmatic when you phone.. Our practice nurses have specialist asthma qualifications. They run clinics in order that asthma may be assessed, advice offered, queries answered and the correct treatment ensured.. Patients on asthma medication should be seen at least once a year in the asthma clinic for a check up with the nurse.. The following factsheets, available from Patient UK give information and advice on a variety of asthma related topics:. What is asthma; who does it affect?. Management of Adult Asthma. Management of Childhood Asthma. Medicines inside inhalers; types of inhaler devices. Peak Flow Meter. For more information please visit the websites below:. External Websites:. NHS Choices - Asthmas symptoms, causes, diagnosis, ...
There is no cure for Asthma; however asthma doesnt have to place significant limitations on your life. With effective treatments and management, symptoms can be controlled, minimizing their impact. Each case of asthma is different and requires treatments to be personalized. One general rule that applies to all is removing environmental factors that worsen ones asthma. Along with removing environmental factors, asthma medications are available to help control symptoms. Asthma medications are divided into two types, quick-relief and long-term and are either inhaled or in pill form. Quick-relief medicines are used to relieve coughing, wheezing and chest tightness that occurs during an asthma episode; long-term medications help control your asthma and are generally used when symptoms happen more than twice a week. For people with asthma, it is important to have an asthma management plan. An asthma management plan is created by you and your doctor. An effective plan should include; identifying and ...
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Methods All persons born in the first week of March in Britain in 1958 were recruited into the cohort. By age 42 9890 cohort members had provided a full occupational history and health information. Job titles and descriptions were initially coded into Standard Occupational Classification 1990 (SOC-90) using a text based computer program. Blind to asthma status we have recoded these jobs into the International Standard Classification of Occupations 1988 (ISCO-88) codes. The prevalence of ever working in jobs defined by these codes was determined. Adult onset asthma was defined as reporting ever asthma at ages 33 or 42 and excluding all those who reporting ever asthma at ages 11 or 16 (childhood asthma). The risk of adult onset asthma associated with these job categories was determined in logistic regression analysis adjusted for sex, smoking, region and fathers social class at birth. The Simes procedure was used to correct for multiple testing. ...
Subjects were recruited prenatally and followed prospectively, attending follow-up at ages 3, 5, 8, and 11 years. A validated questionnaire was interviewer-administered to collect information on parentally-reported symptoms (n=1051). At each follow-up, current rhinitis was defined as sneezing, runny or blocked nose in the absence of cold or flu within the last 12 months, and asthma as a positive response to at least two of the following: 1) current wheeze; 2) physician-diagnosed asthma; 3) use of asthma medication. We measured specific airway resistance (sRaw) using plethysmography (ages 5-11 years) and FEV1 by spirometry (5, 8 and 11). Information on prescribed medication and severe asthma exacerbations (ATS definition) was extracted from participants medical records. The effect of rhinitis on asthma exacerbations and lung function was investigated using longitudinal analyses. ...
Asthma is a chronic lung disease caused by airway inflammation. Asthma is the most common pediatric chronic disease [1, 2] affecting 7.1 million (9.6 %) of American children [3, 4]. Asthma is the primary diagnosis for 1/3 of pediatric emergency department visits [5], and the most frequent reason for preventable pediatric hospitalization [6] and school absenteeism due to chronic conditions [7]. In 2008, 9.3 billion dollars, or 8 % of the total direct healthcare cost for all children, were spent on pediatric asthma [1].. About 80 % of pediatric asthma patients have symptom onset before age six [8, 9], most of them before age three [10-12]. However, only about 1/3 of children with at least one episode of asthmatic symptoms by age three will have asthma at age six and over [10, 13-18]. Asthma is under-diagnosed in 18-75 % of asthmatic children [19-23]. Overdiagnosis of asthma is also prevalent. Eleven percent of patients in primary care using inhaled corticosteroids, the most potent and consistently ...