The aim was to estimate the global numbers of intrapartum stillbirths and intrapartum-related neonatal deaths in 2000. Results indicate that: (1) intrapartum stillbirths are a huge and invisible problem, but are potentially preventable; and (2) intrapartum-related neonatal deaths account for almost 10% of deaths in children under 5 years old. ...
Background and Aim: Arterial duct in term infants is closed 96 h after birth in normal conditions. In some cases, especially in preterm infants, this duct is not closed after birth, which is called patent ductus arteriosus (PDA). This disease, if left untreated, leads to depressed respiratory capacity and shunt in preterm infants. The aim of this study was to compare the effect of oral acetaminophen and ibuprofen on PDA closure in preterm infants. Materials and Methods: In this clinical trial, 50 infants with a gestational age of , 37 weeks with PDA, confirmed by echocardiography and clinical symptoms, were selected and randomly divided into two groups of 25. One group was orally given acetaminophen at 10 mg/kg body weight (BW) every 6 h for 72 h, and another group received ibuprofen at 10 mg/kg BW on the 1st day and then 5 mg/kg on the 2nd and 3rd days. Before and after the intervention, infants were examined for possible side effects using echocardiography. Results: According to the results ...
The study hypothesis is that: Following perinatal asphyxia treatment with a combination of hypothermia and inhaled xenon preserves cerebral metabolism and structure. Following informed parental consent, infants that continue to require endotracheal tube ventilation following resuscitation will be randomised to treatment with hypothermia only or hypothermia and xenon. All infants in both groups will be treated with hypothermia for 72 hours started within 6 hours of delivery and infants allocated to hypothermia and xenon will also receive 30% xenon (balanced with oxygen and air) for 24 hours through a purpose designed delivery system. Structured neurological examination will be done daily during the 1st week after birth and at discharge. MRS and MRI will be performed once between 4-10 days of age. MRS/MRI data analysis will be by investigators blinded to the allocated intervention ...
This is a multicentre prospective randomised controlled trial to determine whether a reduction of body temperature by 3-4°C following perinatal asphyxia improves survival without neurodevelopmental disability.. Full term infants will be randomised within 6 hours of birth to either a control group with the rectal temperature kept at 37 ± 0.2°C or to whole body cooling with the rectal temperature kept at 33.5 ± 0.5°C for 72 hours followed by slow rewarming.. The outcome will be assessed at 18 months of age by survival and neurological and neurodevelopmental testing.. Eligibility criteria:. Term infants less than 6 hours after birth with moderate or severe perinatal asphyxia (a combination of clinical and EEG criteria).. Exclusion criteria:. Infants expected to be 6 hours of age at the time of randomisation or infants with major congenital abnormalities.. Intervention:. Intensive care with whole body cooling versus intensive care without whole body cooling (babies are cooled to 33.5°C for 72 ...
BACKGROUND:. Perinatal asphyxia is an important cause of mortality and permanent neurological and developmental deficit. Early and accurate diagnosis would help to establish the likely prognosis and may also help in determining the most appropriate treatment. Studies in experimental animal models suggest that a protein called Hsp70 may be a good and potentially useful marker of cellular stress that may be clinically useful in determining the presence of neonatal asphyxia.. OBJECTIVES:. Regarding the importance of early and accurate diagnosis of asphyxia, we conducted this study, which is the first investigation of the comparison of the serum Hsp70 antigen level between asphyxiated and healthy infants.. PATIENTS AND METHODS:. In this observational study, the serum concentrations of Hsp70 antigen were compared between neonates suffering from perinatal asphyxia (n = 50) and normal neonates (n = 51). The inclusion criteria for the cases were neonates who had reached term and had at least two ...
Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats. Simola, Nicola; Bustamante, Diego; Pinna, Annalisa; Pontis, Silvia; Morales, Paola; Morelli, Micaela; Herrera-Marschitz, Mario // Experimental Brain Research;Mar2008, Vol. 185 Issue 4, p595 A large body of clinical evidence suggests a possible association between perinatal asphyxia and the onset of early, as well as long-term, neurological and psychiatric disorders including cognitive deficits. The present study investigated cognitive and motor function modifications in a well... ...
Question - Can an online doctor suggest any treatment or medicines for mildly retarded due to neonatal asphyxia with iron deficiency ?. Ask a Doctor about Blood transfusion, Ask a General & Family Physician
This population-based cross-sectional study by Mori et al. presents routinely collected national data from England and Wales to provide estimates of intrapartum-related perinatal mortality rates for booked home births. Intrapartum-related perinatal mortality is a narrowing of the definition of perinatal mortality to exclude deaths from causes other than intrapartum asphyxia, anoxia, or trauma. Although rates of perinatal mortality are more commonly used in studies, the authors use IPPM as a way to reflect the safety of home birth as the location for intrapartum events.. ...
All infants with severe post-asphyxial HIE had evidence of dysfunction of at least one organ/system in addition to the central nervous system. This conforms with the criteria of the American College of Obstetricians and Gynecologists2 and Society of Obstetricians and Gynaecologists of Canada,1 but not with some published reports of organ/system dysfunction in neonates with asphyxia of variable severity.7,8,11,12 The variability in the reported incidence of MOD may be explained by (a) the selection criteria for studies of MOD-at the mild end of the spectrum are cases of "intrapartum asphyxia" with or without HIE during the neonatal period,7,11,12 whereas at the severe end of the spectrum are known cases of cerebral palsy attributed to intrapartum asphyxia8-and (b) the differences in the definition of MOD with respect to the number of organs included in its definition, the definition of "organ/system" (for example, kidneys, hypocalcaemia), and the definition of dysfunction of each ...
Learn more about Perinatal Asphyxia at West Hills Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ....
Background: During the past two decades there has been a sustained decline in child mortality; however, neonatal mortality has remained stagnant. Each year approximately 4 million babies are born asphyxiated resulting in 2 million neonatal deaths and intrapartum stillbirths. Almost all neonatal deaths occur in developing countries, where the majority is delivered at homes with negligible antenatal care and poor perinatal services. Objectives: To identify socio-demographic and clinical risk factors associated with birth asphyxia in Matiari District of Sindh Province, Pakistan. Method: A matched case control study was conducted in Matiari District with 246 cases and 492 controls. Newborn deaths with birth asphyxia diagnosed through verbal autopsy accreditation during 2005 and 2006 were taken as cases. Controls were the live births during the same period, matched on area of residence, gender and age. Result: The factors found to be associated with birth asphyxia mortality in Matiari District of Sindh
Acknowledgements. We are grateful to Gary Darmstadt for input on the scope of the study and for reviewing the manuscript, and Anne Tinker (Save the Children Federation, USA) for support. We thank Simon Cousens for assistance in analysing the VR data and the Child Health Epidemiology Reference Group based in Child and Adolescent Health at WHO for critical review of the methods. We appreciate the help given by Kate Wilczynska-Ketende with literature searches. We thank Doris Ma Fat, Colin Mathers and Mie Inoue for providing data related to the WHO mortality database. We acknowledge the following for supplying unpublished data sets: Adult Morbidity and Mortality Project, Ministry of Health, United Republic of Tanzania, particularly Philip Setel, Dave Whiting and Yusuf Hemed; Ana Maria Aguilar (BASICS II, Bolivia); Zulfiqar Bhutta (Aga Khan University, Karachi, Pakistan); Fariyal Fikree (Population Council, New York, USA); Professor Henry Perry (Future Generations, Franklin West, Virginia, USA, ...
R. J. Tozer1, N. Aladangady1,2. 1Neonatal Unit, Homerton University Hospital, London; 2Barts and The London Queen Marys School of Medicine, London. Introduction: Severe birth asphyxia is associated with poor neurodevelopmental outcome and withdrawal of intensive care is appropriate in certain situations. We report reactions of the parents of two severely asphyxiated infants to withdrawal of intensive care.. Case 1: A male infant born at 41 weeks gestation by emergency caesarean section because of fetal bradycardia. Uterine rupture was found at operation with the baby in the abdominal cavity. His condition was very poor at birth, APGAR scores 11, 35, 310; cord pH was 6.6. Heart rate improved rapidly with ventilation but he failed to develop spontaneous respiration. He was grossly hypotonic and developed seizures within 2 h, cerebral function monitoring showed a flat trace. Withdrawal was recommended but initially refused by his black, African, Catholic parents on religious grounds. After ...
Aim: To determine the prevalence and independent relationship between hearing loss and risk factors in a representative neonatal intensive care unit (NICU) population. Methods: Automated auditory brainstem response (AABR) hearing screening has been introduced since 1998 in the Dutch NICUs. After a second AABR failure, diagnostic ABR was used to establish diagnosis of hearing loss. Newborns who died before the age of 3 months were excluded. In the present study only the NICU infants who were born with a gestational age ,30 weeks and/or a birth weight ,1000 g between October 1, 1998 and January 1, 2002 were included. Risk factors included in the study were familial hearing loss, in utero infections, craniofacial anomalies, birth weight ,1500g, hyperbilirubinemia, ototoxic medications, cerebral complications, severe birth asphyxia, assisted ventilation ≥5 days and syndromes. Results: A nationwide cohort of 2186 newborns were included. Mean gestational age was 28.5 weeks (SD 1.6) and mean birth ...
Birth asphyxia is a condition in which a baby cant breathe properly after birth. If birth asphyxia is not immediately addressed...
Of the three million neonatal deaths which occurred globally in 2012, 779,000 took place in India. In India, perinatal asphyxia contributes to 20% of neonatal mortality (NMR) and 50% of early neonatal mortality (ENM) - 400 children losing their lives daily - a major public health problem. Asphyxia can result in coma, irregular breathing, absence of neonatal reflexes, dilated pupils, irregular heart rates, and seizures which can lead to brain cell dysfunction, injury, and death if untreated. Most seriously, asphyxia can cause injury to the central nervous system. This injury is termed Hypoxic Ischemic Encephalopathy (HIE ...
Download this Vector Background Pattern Of Snail vector illustration now. And search more of the webs best library of royalty-free vector art from iStock.
Azzopardi et al (1) report the experience of introducing total body cooling as a standard form of therapy for infants with moderate or severe perinatal asphyxia. It is notable that this publication includes only one level 2 neonatal intensive care unit of the 25 units providing data for the TOBY register (Royal Cornwall Hospital, Truro). The Royal Devon and Exeter Hospital (also a level 2 unit) has since joined the TOBY register having participated in the TOBY trial. Part of the success in recruitment to the TOBY trial was due to the trial being rolled out to many more units in the second phase of the trial (2). The Peninsula Neonatal Network level 3 unit at Derriford Hospital in Plymouth participated in this trial as did the two level 2 units in Exeter and Truro. All the units were very well supported by training days set up at the units by the TOBY trial investigators. In the Peninsula Neonatal Network this system of care has continued and total body cooling is provided at the three units that ...
Methods 20 preterm lambs (80-90% GE) were used. Lambs were randomly assigned to receive intravenous WIN55212-2 (100 or 0.01 μg/kg) or not (sham) after hypoxic-ischaemic injury induced by partial cord clamping. A non-injured group was used as control. Carotid blood flow, systemic arterial pressure (SAP), heart rate (HR) and gas exchange were measured at fetal point, at the end of hypoxic-ischaemic injury and during neonatal life. Analysis of variance, p,0.05. ...
Director of the CDC, Dr Tom Frieden said today: There is no longer any doubt that Zika causes microcephaly. The defect causes babies to be born with abnormally small heads and brain damage.
The Centers for Disease Control and Prevention said Wednesday the time has come to drop the squishy language previously used to describe the Zika virus.
Getting the right treatment for birth asphyxia as soon as possible can help reduce the damaging effects of an interruption to your babys oxygen supply.
Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and hepatology. The journal welcomes submissions related to the medical, surgical, pathological, biochemical, and physiological aspects of these subject areas.
Perinatal asphyxia resulting in hypoxia-ischemia (HI)-related brain injury leads to severe, life-long morbidities in thousands of neonates and children born in the U.S. each year (Ferriero, 2004; Nelson and Lynch, 2004; Drobyshevsky et al., 2007; Hill and Fitch, 2012). The physical, emotional, and economic toll taken by these adverse early childhood events is incalculable. Interestingly, clinical studies indicate that male neonate brains are more susceptible to the effects of perinatal asphyxia (Vannucci and Hurn, 2009; Hill and Fitch, 2012) resulting in greater long-term cognitive deficits compared with females with comparable brain injury (Marlow et al., 2005; Tioseco et al., 2006; Hill and Fitch, 2012). In addition, males show increased risk for brain-based developmental disorders including learning disabilities and cerebral palsy compared with females (Donders and Hoffman, 2002; Rutter et al., 2003). The relative resistance of female neonatal brain to adverse consequences of HI suggests that ...
Overview of Birth Defects What is a birth defect? A birth defect is a health problem or physical change, which is present in a baby at the time he/she is born. Birth defects may be very mild, where the baby looks and acts like any other baby, or birth defects may be very severe, where you can immediately tell there is a health problem present. Some of the severe birth defects can be life threatening, where a baby may only live a few months, or may die at a young age (in their teens, for example). Birt...
Scientists are always trying to identify the next threat before it reaches epidemic or pandemic proportions. Both humans and diseases are constantly changing, so its a bit like trying to hit a moving target from a moving car.. "Were trying to predict really, really rare events from not much information, which I think is going to fail," Dr Geoghegan said - and history agrees.. For example, scientists discovered the Zika virus in Uganda way back in 1947, and yet there was an outbreak on the other side of the world, in Brazil, two years ago.. The disease is spread by mosquitoes, and can cause severe birth defects in babies if the mother is bitten while pregnant.. Similarly, the Ebola virus was discovered in 1976 in South Sudan, but it claimed a reported 11,315 lives in west Africa three years ago.. It is highly infectious and spreads through transmission of bodily fluids, causing a gruesome death as the whole body haemorrhages.. Still other diseases emerge totally out of the blue.. One example is ...
Scientists are always trying to identify the next threat before it reaches epidemic or pandemic proportions. Both humans and diseases are constantly changing, so its a bit like trying to hit a moving target from a moving car.. "Were trying to predict really, really rare events from not much information, which I think is going to fail," Dr Geoghegan said - and history agrees.. For example, scientists discovered the Zika virus in Uganda way back in 1947, and yet there was an outbreak on the other side of the world, in Brazil, two years ago.. The disease is spread by mosquitoes, and can cause severe birth defects in babies if the mother is bitten while pregnant.. Similarly, the Ebola virus was discovered in 1976 in South Sudan, but it claimed a reported 11,315 lives in west Africa three years ago.. It is highly infectious and spreads through transmission of bodily fluids, causing a gruesome death as the whole body haemorrhages.. Still other diseases emerge totally out of the blue.. One example is ...
The Zika virus that has spread to more than 50 countries is no longer considered an international public health emergency, the World Health Organization declared Friday. But the change in designation does not represent a downgrading of Zikas importance, officials said. The WHO labeled Zika an international emergency in February primarily to understand what was causing the "extraordinary clustering" of microcephaly cases in Brazil, the epicenter of the outbreak, said David Heymann, who chairs the expert panel that made the recommendation. When the emergency was declared, he said, researchers had not yet proven that the mosquito-borne virus causes the severe birth defect characterized by an abnormally small head and underdeveloped brain. Studies have since established the link between Zika and microcephaly. Now, the best way to tackle the virus and its serious complications is for the WHO to manage "this significant and enduring public health challenge" within the organization, Heymann said. That ...
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre, aggressive, or violent behavior; bowel pain; chest pain or pounding in the chest; dark urine; depression; difficult or painful swallowing; difficulty moving; excessive thirst or urination; fainting; fast heartbeat; fever; fractured or weak bones; hearing problems or ringing in the ears; increased pressure in the brain (pressure in the eye; nausea; vision changes; vomiting); joint or back pain; leg swelling; muscle weakness with or without pain; nausea; new or worsening heartburn; rectal bleeding; red patches or bruises on the legs; shortness of breath; seizures; severe birth defects; severe diarrhea; severe headache; skin infection; slurred speech; stomach pain or tenderness; stroke; stunted growth in children; sun sensitivity; swelling of the pancreas (fever; increased heartbeat; nausea; stomach tenderness; vomiting); swollen glands; thoughts of suicide; ...
In particular, young women who could become pregnant, pregnant women and couples considering pregnancy need to be cautious because Zika virus can cause severe birth defects. Couples planning pregnancy when either partner has been exposed to Zika virus should speak with a health care provider about a safe time to try to get pregnant. A health care provider can also provide information on the most effective contraceptive methods. Pregnant women are urged to avoid travel to areas with known Zika transmission if at all possible. If travel is necessary, it is extremely important to take steps to prevent mosquito bites ...
The last time I went to my rheumatologist was back in September and he told me that he wanted to put me on a new (to me) medicine because my RA was becoming much more aggressive and he wanted to try and stop the joint destruction. I was so miserable and in so much pain that at that point I was ready to try anything (except the TNF/biologic drugs), then he told me that I would have to prevent pregnancy. That I would have to make sure that there was no way that I would become pregnant while I was on it. I heard things like: "It is a Teratogen. Fetal mortality. Severe birth defects. End any accidental pregnancy. Long processes & more drugs to remove it from your system. Monthly blood tests. Liver tests." Then he said, "But, youre a woman in your 40s. Women in their 40s arent usually looking to get pregnant ...
GENEVA The World Health Organization (WHO) called on Wednesday for $56 million to combat the Zika virus, a disease that has been linked to severe birth defects in Brazil and has spread to 39 countries. The funds sought would be used until June to fast-track vaccines, carry out diagnostics and research into how the mosquito-borne virus spreads, as well as virus control, the WHO said.
Zika infection during pregnancy has been linked to severe birth defects. If you are pregnant or thinking about getting pregnant, it is important to be aware of the risks associated with the virus.
B-Complex 100 may help provide energy production and stress relief. It is a balanced complete formula containing 8 essential vitamins that make up the B complex. The timed release formula allows the gradual release of the vitamins over 6 to 8 hours allowing the body to digest the vitamins more effectively B vitamins play a very important role in mood, cardiovascular health, cancer prevention and immunity. Folic Acid and other B vitamins seem even more of a wonder drug than anyone suspected. Already known to prevent severe birth defects and heart attacks, they may also ward off broken bones from osteoporosis, two major studies suggest. B vitamins are known to reduce levels of homocysteine, an amino acid already linked, at high levels, to an increased risk of heart attacks, strokes and Alzheimers disease.
Cloned-animal meat will NOT be labelled. Ignoring the scientific evidence that cloning poses serious risks to animal welfare, including severe birth defects, painful disease, and premature death, the FDA is close to permitting cloned foods onto our grocer
Soldiers will be making house-to-house visits to spread awareness of the mosquito-borne virus. Brazil is deploying more than 200,000 soldiers to battle the Zika virus, which is believed to cause severe birth defects, the health ministry announced Wednesday. The troops will make house-to-house visits to spread awareness of the mosquito-borne virus, handing out leaflets…
Doctors help you with trusted information about Pimples in Acne: Dr. Charlap on toxic exposure maternal acne medications: A couple of the most well-known fetal reactions to antibiotics: permanent staining of the teeth, with use of tetracyclines, and severe birth defects associated with isotretinoin.
When I felt a contraction, I was told to push for 10 seconds, so I did... & again, & again... Then the next contraction, as I was pushing the dr & nurse could see my babys head coming. I was getting excited & hoped I wouldnt be pushing for long. But the next contraction felt different... it felt weaker, but I pushed anyway, & after that set the contraction didnt stop, it kind of lingered on, although not as strong as a normal one. It just felt weird. My nurse looked confused as she watched the monitor. The dr & nurse could no longer see the babys head. So the next (still kind of strange feeling) contraction came,and the nurse seemed confused if it was a contraction or not, but it seemed like it was... they told me to push harder, but the head was gone, so the dr had me roll over to lay on my right side, then my left side... & afterwards the dr felt inside & could not feel the babys head at all. She kept feeling around & the nurse said, What do you feel? The dr said, .....Its an ...
2.0 - January 15, 2014 - More controls. More background pattern options. Added a slew of google font faces you can choose in the control panel. Separate body and header font chooser. Choose to have the image panels scroll with the page for better image containment.. 1.7 - December 30, 2013 - fixed layout tool column issue (.first).. 1.6 - December 19, 2013 - Added custom 404 and login pages. 1.5.2 - June 19, 2013 - Reduced size of included images for panels. 1.5.1 - June 6, 2013 - Added ability and custom block to easily build a one page site. Updated icon, thumbnail. Installs new attribute.. 1.0 - May 28, 2013 - Initial code. ...
1 x A4 sheet. Can be die cut to create a shimmery background pattern i.e. die cut lots of flowers/snowflakes then stick onto the background of a card, scrapbook page, vase or glassware to create an effective background of shimmery die cut shapes.. The sparkly sheet can also be stuck onto the material you want to die cut first. This will create a shimmer effect over the initial choice of card, leather, balsa wood, decorative paper, etc.. Stamping : stamp and colour the image. Tim to size. Then cover with the sparkly sheet to give an overall shimmer.. ...
Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially lifting costs to health systems. The Global Burden of Disease 2016 Study provided an assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016.. Deaths from noncommunicable diseases represented 72.3% of all deaths in 2016, with 19.3% of deaths in that year occurring from CMNN diseases.. In 2016, the three leading global causes of death in children under five were lower respiratory infections, neonatal preterm birth complications and neonatal encephalopathy because of birth asphyxia and trauma.. Between 1990 and 2016, a shift toward deaths at older ages occurred, with a 178% increase in deaths in ages 90 and 94 years and a 210% increase in deaths older than age 95 years.. The 10 leading causes by rates of age-standardized YLL declined from 2006 to 2016; the median annualized rate of change for all other ...
In low-income countries, nearly 4 in every 10 deaths are among children under 15 years, and only 2 in every 10 deaths are among people aged 70 years and older. People predominantly die of infectious diseases: lower respiratory infections, HIV/AIDS, diarrhoeal diseases, malaria and tuberculosis collectively account for almost one third of all deaths in these countries. Complications of childbirth due to prematurity, and birth asphyxia and birth trauma are among the leading causes of death, claiming the lives of many newborns and infants ...
Fetal life occurs in a relatively hypoxic environment. During normal pregnancy, several compensatory mechanisms secure fetal oxygenation and wellbeing. In complicated pregnancies, however, intrauterine hypoxia predisposes the fetus to growth restriction, stillbirth, neurodevelopmental sequelae such as cognitive dysfunction and cerebral palsy (CP), and adverse long-term health impacts. Impairment of respiratory gas exchange-during either pregnancy or delivery-leads to tissue hypoxia, and, if prolonged, to metabolic acidosis and asphyxia. Worldwide, such asphyxia, diagnosed at birth, annually accounts for a million neonatal deaths. Furthermore, neonatal hypoxic ischemic encephalopathy (HIE) originating from perinatal asphyxia may lead to a variety of neurodevelopmental impairments. Therapeutic neuroprotective interventions such as hypothermia have significantly improved the prognosis of severe neonatal encephalopathy. Increased risk for intrauterine fetal hypoxia and perinatal asphyxia occur in ...
TY - JOUR. T1 - Reduction in cerebral blood flow volume in infants complicated with hypoxic ischemic encephalopathy resulting in cerebral palsy. AU - Fukuda, Sumio. AU - Mizuno, Keisuke. AU - Kawai, Satomi. AU - Kakita, Hiroki. AU - Goto, Tatenobu. AU - Hussein, Mohamed Hamed. AU - Daoud, Ghada A.. AU - Ito, Tetsuya. AU - Kato, Ineko. AU - Suzuki, Satoshi. AU - Togari, Hajime. PY - 2008/4/1. Y1 - 2008/4/1. N2 - Hypoxic ischemic brain can result in cerebral palsy, mental retardation, and learning disabilities in surviving children. The purpose of this study was to elucidate the cerebral blood flow volume in infants complicated with brain damage after the birth. Nine term infants with hypoxic ischemic encephalopathy and 41 normal term infants were studied. Four infants with HIE suffered from CP or mental retardation, and the other five infants exhibited normal neurodevelopment. The mean blood flow velocity and diameter of the internal carotid artery and the vertebral artery were measured for 28 ...
TY - JOUR. T1 - Servo controlled versus manual cooling methods in neonates with hypoxic ischemic encephalopathy. AU - Buchiboyina, Ashok. AU - Ma, Eric. AU - Yip, Andrew. AU - Wagh, Deepika. AU - Tan, Jason. AU - McMichael, Judy. AU - Bulsara, Max K.. AU - Rao, Shripada. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Background Therapeutic hypothermia is known to improve outcomes in neonates with hypoxic ischemic encephalopathy (HIE). There are no studies that have compared servo controlled cooling (SCC) versus manually controlled cooling (MCC) methods in HIE. Aim To compare the outcomes of SCC versus MCC in neonates with HIE. Methods and outcome measures Between Jan 2008 and May 2011, MCC with cool-gel packs was used to achieve rectal temperatures of 33.5 to 34.5 °C in our units. Subsequently, we changed to SCC to achieve rectal temperatures of 33 to 34 °C. 105 neonates received SCC whereas 95 received MCC. Retrospective study with multivariate analysis was conducted comparing thermoregulation (primary ...
To examine the blood glucose profile and the relationship between blood glucose levels and neurodevelopmental outcome in term infants with hypoxic-ischaemic encephalopathy. Blood glucose values within 72 hours of birth were collected from 52 term infants with hypoxic-ischaemic encephalopathy. Hypoglycaemia [| 46.8 mg/dL (2.6 mmol/L)] and hyperglycaemia [| 150 mg/dL (8.3 mmol/L)] were correlated to neurodevelopmental outcome at 24 months of age. Four fifths of the 468 blood samples were in the normoglycaemic range (392/468:83.8%). Of the remaining 76 samples, 51.3% were in the hypoglycaemic range and (48.7%) were hyperglycaemic. A quarter of the hypoglycaemic samples (28.2%:11/39) and a third of the hyperglycaemic samples (32.4%:12/37) were recorded within the first 30 minutes of life. Mean (SD) blood glucose values did not differ between infants with normal and abnormal outcomes [4.89(2.28) mmol/L and 5.02(2.35) mmol/L, p value = 0.15] respectively. In term infants with hypoxic-ischaemic encephalopathy,
Purpose : We demonstrate use of bedside eye imaging to detect severity of retinal abnormalities in infants with hypoxic ischemic encephalopathy (HIE). In prior neurodevelopmental research retinal findings on OCT were linked to brain injury and poor outcomes in preterm infants. We hypothesize that retinal injury will reflect patterns and severity of brain injury due to HIE. Methods : We used a hand-held, bedside, non-contact spectral-domain optical coherence tomography (SDOCT) imaging system (Envisu 2300, Bioptigen, North Carolina) under a protocol approved by Duke Institutional Review Board and after obtaining consent from a parent/guardian. All infants were imaged without pharmacologic dilation. Eligible preterm and term infants with HIE were imaged within 24 hours of hypothermia initiation (cooling), 72 hours after birth (re-warming), 5 days (time of magnetic-resonance imaging (MRI)) and weekly thereafter until discharged depending on the systemic stability of the infant. We compared retinal ...
Learn more about Hypoxic Ischemic Encephalopathy at Grand Strand Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Hypoxic Ischemic Encephalopathy at Colleton Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Hypoxic Ischemic Encephalopathy at Medical City Dallas DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...