The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs
This study suggests that the APOB polymorphism rs679899 is associated with type 2 diabetes and GGT levels, while the LIPC polymorphism rs6083 may influence CHOL, TG, and LDL levels in Chinese Han population.
Loci with genome-wide associations with schizophrenia in the Han Chinese population - Volume 207 Issue 6 - Zhiqiang Li, Yuqian Xiang, Jianhua Chen, Qiaoli Li, Jiawei Shen, Yun Liu, Wenjin Li, Qinghe Xing, Qingzhong Wang, Lei Wang, Guoyin Feng, Lin He, Xinzhi Zhao, Yongyong Shi
The JAK2-STAT3 pathway is a signaling target of a multitude of cytokines that are thought to play significant biological roles in immune-mediated diseases. This pathway is essential in Th1 cell differentiation and proliferation. Additionally, it is also important for the development of Th17 cells. 12 Both Th1 and Th17 cells play critical roles in immune-mediated diseases such as BD. 26 The JAK2 and STAT3 signaling pathway may thus exert its influence on immune-mediated diseases, including BD, by modulating the Th1 and Th17 response. Recently, genetics polymorphisms of JAK2 and STAT3 have been investigated for their association with a number of autoimmune diseases including Crohns disease and ulcerative colitis. 20,27 -32 All these results prompted us to examine whether the polymorphisms of the JAK2 and STAT3 genes could possibly also contribute to the development of BD in a Han Chinese population. To ensure the results, we made the following efforts. First, we strictly selected the patients ...
Sigma-Aldrich offers abstracts and full-text articles by [Xingwang Li, Jing Zhang, Yang Wang, Jue Ji, Fengping Yang, Chunling Wan, Peng Wang, Guoyin Feng, Klaus Lindpaintner, Lin He, Guang He].
Objective: Our objective was to compare total body fat to lean mass ratio (F:LM) in Aboriginal, Chinese, European, and South Asian individuals with differences in insulin resistance.. …. Results: After adjustment for confounders and at a given body fat, South Asian men had less lean mass than Aboriginal [3.42 kg less; 95% confidence interval (CI) = 1.55-5.29], Chinese (3.01 kg less; 95% CI = 1.33-4.70), and European (3.57 kg less; 95% CI = 1.82-5.33) men, whereas South Asian women had less lean mass than Aboriginal (1.98 kg less; 95% CI = 0.45-3.50), Chinese (2.24 kg less; 95% CI = 0.81-3.68), and European (2.97 kg less; 95% CI = 1.67-4.27) women. In adjusted models, F:LM was higher in South Asian compared with Chinese and European men and higher in South Asian compared with Aboriginal, Chinese, and European women (P < 0.01 for all). Insulin and HOMA were greatest in South Asians after adjustment; however, these differences were no longer apparent when F:LM was considered.. Conclusions: South ...
This study investigated bioavailability of pegvisomant single 30 mg/ml subcutaneous injection versus two 15 mg/ml subcutaneous injection in healthy Asian
Heart attacks strike South Asian men and women at younger ages and are more deadly compared to people from other world regions. [...] last month, Stanford Health Care opened the Stanford South Asian Translational Heart Initiative, a program that will treat existing heart patients, screen potential ones and conduct research. Dr. Rajesh Dash, medical and scientific director for the Stanford initiative, explained that genetics seem to put South Asians in harms way, even when their cholesterol and blood glucose levels and body mass index measurements are just a little elevated. 4 times South Asians risk of heart disease is four times greater than the general world populations, according to statistics provided by the South Asian Heart Center at El Camino Hospital.
A mongoloid baby is crying on the subway and so now everyone is a hostage. Everyone is either sitting next to or across from the baby or standing up and away from it but we might as well be bound and gagged in the back of a gas station. We all look at each other like we dont know what but its undeniable and true that we want this baby dead or to stop crying so we can go back to the magazine we are reading or the music we are listening to or the frayed hem of the skirt we cant stop touching. Everyone feels badly about this, about wanting this baby dead or to stop crying because it is a Mongoloid baby and it is the middle of the day. Perhaps if it were early morning or late at night people would feel differently and yes, its true, that everyone knows youre not supposed to call this kind of baby a Mongoloid anymore, but this is what we call him. Maybe if this baby werent a Mongoloid everyone would feel differently, but theres no way of knowing. We think most people dont want to be around a ...
Mongoloid Slant Symptom Checker: Possible causes include Kaufman Oculocerebrofacial Syndrome. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
antiMUSIC.com news - Aerosmith Feuding- Motley Sued- Behemoth Singer Leaves Hospital- Cold War Kids Leak- Mongoloids Split?- Foo Fighters Movie- Corey Taylor Book Delayed- more
Impacts of Cytochrome P450 2D6*10 Allele and a High-Fat Meal on the Pharmacokinetics of Dapoxetine in Healthy Chinese Men: A Single-Dose, Two-Treatment Study
The reason why, the researchers said, is because their bodies store extra fat differently. Rather than distributing it throughout the body under the skin, as is the case with people from most ethnic groups, the bodies of individuals of South Asian descent store the fat around the internal organs of the abdomen. This is known as visceral fat ...
Evolutionary biologists call it the r-K scale of reproductive strategies. At one end of this scale are r-strategies that rely on high reproductive rates. At the other end are K-strategies that rely on high levels of parental care. This scale is generally used to compare the life histories of different species of animals. I have used it to explain the smaller but real differences between the human races.. On this scale, Orientals are more K-selected than Whites, while Whites are more K-selected than Blacks. Highly K-selected women produce fewer eggs (and have bigger brains) than r-selected women. Highly K-selected men invest time and energy in their children rather than the pursuit of sexual thrills. They are "dads" rather than "cads.". Chapter 7 shows that the race differences in reproductive strategies make sense in terms of human evolution. Modern humans evolved in Africa about 200,000 years ago. Africans and non-Africans then split about 100,000 years ago. Orientals and Whites split about ...
rs2024513 is a SNP in the neurexin-1 NRXN1 gene on chromosome 2p16.3. Based on a case-control study of 700+ Han Chinese patients with schizophrenia, rs2024513(A) was associated with higher risk, at an odds ratio of 1.3 (CI: 1.07 - 1.56, p=0.006).[PMID 21477380 ...
Quote: Originally Posted by Looking for a fight You seem a multiculturalist speaking. The speaking of the facts that we have today...
A condition which, as its name suggests, is most common among people of Asian descent, although it can be found to a lesser extent in individuals from ...
Vol 8: Association between IL-21 gene rs907715 polymorphisms and Graves- disease in a Southern Chinese population.. This article is from Experimental and Therapeutic Medicine, volume 8.AbstractInterleukin-21 (IL-21) is a pleiotropic cyt. Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Allelic diversity and haplotype structure of HLA loci in the Chinese Han population living in the Guanzhong region of the Shaanxi province. AU - Shen, Chun Mei. AU - Zhu, Bo Feng. AU - Ye, Shi Hui. AU - Liu, Meng Li. AU - Yang, Guang. AU - Liu, Sheng. AU - Qin, Hai Xia. AU - Zhang, Hua Dong. AU - Lucas, Rudolf. AU - Li, Shen Bing. PY - 2010/6/1. Y1 - 2010/6/1. N2 - The allele and haplotype frequencies of HLA-A, -B and -DRB1 loci in 10,000 healthy unrelated Han individuals living in the Guanzhong region of the Shaanxi Province were analyzed with the methods of SSO, SSP and SBT. Subsequently, these data were compared with results obtained in Han populations living in other regions as well as to other ethnic groups, using genetic distance measurements, neighbor-joining dendrograms and principal component analysis. In total 18 alleles were detected at the HLA-A locus, 46 alleles at the HLA-B locus and 14 alleles at the HLA-DRB1 locus. HLA-A02 was the most common HLA-A allele ...
Chronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. Few gene studies of the Chinese population have focused on COPD. We investigated candidate genes associated with susceptibility to COPD in the Chinese Han population. A total of 331 COPD patients and 213 control subjects were recruited for this study. Nighty-seven single-nucleotide polymorphisms (SNPs) of 46 genes were selected for genotyping. Genotypes were determined using multiplex polymerase chain reaction (PCR). Significant differences between patients and healthy controls were observed in the allele frequencies of seven SNPs: rs1205 C, rs2353397 C, rs20541 T, rs2070600 G, rs10947233 G, rs1800629 G, and rs2241712 A. After Bonferroni correction, rs2353397 C was most strongly associated with susceptibility to COPD. Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD
Aims: To describe the prevalence and causes of decreased visual acuity (VA) in Singaporean Chinese children. Methods: A population-based survey of Singaporean Chinese children aged 6 to 72 months was conducted. Participants underwent an orthoptic evaluation, cycloplegic refraction and biometric measurements. A sub-group of children aged 30 to 72 months with presenting logMAR VA were included in this analysis. Retesting was performed on the same day or another day by predefined criteria with best refractive correction. Decreased VA was defined as worse than 20/50 (0.4 logMAR) for ages 30 to 47 months and worse than 20/40 (0.3 logMAR) for ages 48 to 72 months. Results: The study examined 3009 children (participation rate 72.3%) of which 2017 children aged 30 to 72 months were eligible for VA testing and completed in 1684 (83.5%). In children aged 30-47 months, the prevalence of decreased presenting VA was 2.1%, and in children 48-72 months, it was 2.05%, with no significant difference between boys ...
The present study was performed to investigate the association of IL23R polymorphisms with Fuchs syndrome in a Chinese Han population. The results showed that the AA genotype of the rs11209032 SNP was associated with an increased susceptibility to Fuchs syndrome. However, there was no difference with regard to the genotypes and alleles of rs7517847 and rs17375018 between patients with Fuchs syndrome and normal controls. Fuchs syndrome is a relatively rare uveitis entity [2]. Although the etiology and pathogenesis of Fuchs syndrome are not fully understood, several hypotheses including sympathetic lesions, association with ocular toxoplasmosis, vascular abnormalities, viral infections and autoimmunity have been proposed [15,16]. Among these presumptions, a viral infection has been accepted, as supported by the demonstration of local intraocular antiviral antibody production [16-18],Elevatedγ-interferon and interleukin 10, an increased number of CD8+ T cells in the aqueous humor and a ...
For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score, four factors and the AKT1 rs2494746 and rs3001371 polymorphisms. The results indicate that there is a significant association between suicidal ideation and anxiety symptoms in depressed patients and the rs2494746 polymorphism. The other AKT1 polymorphism, rs3001371, was significantly associated with work and activities. Patients with the rs3001371-A allele had a significantly more severe illness compared to patients with the rs3001371-G allele. Thus, AKT1 polymorphisms appear to be associated with depression severity, anxiety symptoms, work and activities, and suicide attempts in patients with depressive disorder.
In a prospective study of a general Japanese population, we clearly demonstrated that elevated HbA1c levels, even in the prediabetic range, were a significant risk factor for the development of CVD, especially for CHD and ischaemic stroke, in a general Japanese population. These associations remained robust even after controlling for comprehensive confounding factors. Furthermore, adding the HbA1c value to the confounding factors significantly improved the predictive ability for total CVD. These findings are important in that they indicate HbA1cs value for predicting the long-term risk of CVD in Japanese.. Some clinical and population-based cohort studies have shown that increased HbA1c levels were positively associated with the risks of CVDs and mortality [6-11, 20-25]. In the present study, the risks of CHD and ischaemic stroke were significantly or marginally higher even in the subjects with HbA1c levels of ≥5.5% compared with those with HbA1c levels of ≤5.0%. There has been controversy ...
GSK2190915 is currently in development for the treatment of asthma. This study aims to assess the safety and tolerability of single doses of GSK2190915 in healthy Japanese subjects. The study will also look at the pharmacokinetics (PK) and pharmacodynamics (PD) of single doses of GSK2190915 and aims to characterise the PK/PD relationship in healthy Japanese subjects. Twelve healthy Japanese subjects will take part in this single escalating dose study and subjects will receive one of five possible treatments, 10 mg, 50 mg, 150 mg, 450 mg GSK2190915 or placebo in each treatment period. Blood samples (for safety, pharmacokinetics and pharmacodynamics), urine samples (for safety and pharmacodynamics) and ECGs, blood pressure readings, physical examinations and a review of adverse events will take place at a number of timepoints pre and post each dose. A minimum 7 day washout between treatment periods will be required. Regardless if a subject completes or prematurely withdraws from the study, a ...
The principal function of NILTs is to identify patients with high probability of having advanced fibrosis at the time of testing. Currently, decisions such as management in primary or secondary care or consideration for clinical trials are largely based on the results of these NILTs. As with any clinical test, there is a danger that if applied or interpreted inappropriately, wrong decisions can be made and, ultimately, harm may come to a patient. Despite the relatively small sample size, our data show that the sensitivity of commonly used NILTs is lower in patients of South Asian ethnicity suggesting that large numbers of South Asian patients may be inappropriately reassured that they do not have advanced disease. We recorded self-reported ethnicity and not first or subsequent generation immigration. Nevertheless, our data suggest that NASH may be more aggressive in South Asian patients who are almost a decade younger, have lower BMI and less severe BMI category than white patients with ...
Background Telomerase expression is one of the characteristics of gastric cancer (GC) cells and telomerase activity is frequently up-regulated by a variety of mechanisms during GC development....
PK samples at pre-dose, 0.25h, 0.5h, 0.75h, 1h, 1.5h, 2h, 2.5h, 3h, 4h, 5h, 6h, 8h, 10h, 12h, 16h and 24h, 36h, 48h, 72h, 96h, 120h, 144h and 168h post dose after single dose and at the time points pre-dose, 0.25h, 0.5h, 0.75h, 1h, 1.5h, 2h, 2.5h, 3h, 4h, 5h, 6h, 8h, 10h, 12h, 16h and 24h after administration of a repeated ...
Chinese peoples joints wear out too, but replacement implants have, on occasion, been too large. Now a team of 21 experts from France and Chinas Sichuan
TY - JOUR. T1 - The proportion of individuals with alcohol-induced hypertension among total hypertensives in a general japanese population. T2 - NIPPON DATA90. AU - Nakamura, Koshi. AU - Okamura, Tomonori. AU - Hayakawa, Takehito. AU - Hozawa, Atsushi. AU - Kadowaki, Takashi. AU - Murakami, Yoshitaka. AU - Kita, Yoshikuni. AU - Okayama, Akira. AU - Ueshima, Hirotsugu. AU - Iimura, Osamu. AU - Omae, Teruo. AU - Ueda, Kazuo. AU - Yanagawa, Hiroshi. AU - Horibe, Hiroshi. AU - Kodama, Kazunori. AU - Kasagi, Fumiyoshi. AU - Tanihara, Shinichi. AU - Saito, Shigeyuki. AU - Sakata, Kiyomi. AU - Nakamura, Yosikazu. AU - Kakuno, Fumihiko. AU - Takeuchi, Toshihiro. AU - Hasebe, Mitsuru. AU - Kusano, Fumitsugu. AU - Kawamoto, Takahisa. AU - Minowa, Masumi. AU - Iida, Minoru. AU - Hashimoto, Tsutomu. AU - Tanaka, Shigemichi. AU - Terao, Atsushi. AU - Kawaminami, Katsuhiko. AU - Sawai, Koryo. AU - Shibata, Shigeo. PY - 2007/8/1. Y1 - 2007/8/1. N2 - Japanese men consume more alcoholic beverages than men in ...
List of causes of Mongoloid palpebral fissure in children and Respiratory symptoms, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Xu, Ying, Lek, Ngee, Cheung, Yin Bun, Biswas, Arijit, Su, Lin Lin, Kwek, Yung Chiang Kenneth, Yeo, Seow Heong George, Soh, Shu E, Saw, Seang Mei, Gluckman, Peter David, Chong, Yap Seng (2015-06-25). Unconditional and conditional standards for fetal abdominal circumference and estimated fetal weight in an ethnic Chinese population: a birth cohort study. BMC Pregnancy and Childbirth 15 (141) : 1-11. [email protected] Repository. https://doi.org/10.1186/s12884-015-0569- ...
To identify the single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of human SCN7A (sodium channel, voltage-gated, type VII, alpha polypeptide) gene and to investigate the association of some of these SNPs with essential hypertension (EH) in Chinese.The promoter region, exons, as well as part of the introns of SCN7A gene were sequenced by a fluorescent labeling automatic sequencing method to identify and characterize the SNPs in Chinese population. SNP genotyping was performed by PCR-RFLP or direct DNA sequencing in unrelated EH patients and normotensive controls from a Chinese Han population residing in Shanghai area. Case-control studies on seven SNPs were first carried out in 96 patients and 96 normotensive controls. The positive finding was further verified in an extended study containing 288 patients and 288 controls.Thirty-two SNPs were identified through a 13,132 bp sequencing of SCN7A gene. Among them, seven were in regulatory region, ten in coding regions, one in ...
With increasing number of epidemiological studies about BLL in China in recent years, it is now possible to obtain direct evidence of lead poisoning situation of Chinese population aged 0-18 years old. Based on strict inclusion criteria, eliminated relative low-quality studies by quality assessment of cross-sectional study, we identified 55 articles in this meta-analysis including 200,002 subjects, covering 19 provinces, autonomous regions and municipalities, thus the large population guaranteed the reliability of this study.. In this study, pooled rate of BLL ≥10 μg/dL in the 0-18 year old Chinese population during 1990-2012 was 25.1 % and corrected pooled rate under trim and fill method was 9 %, both much higher than all levels during 1991-1994 (4.4 %), 1999-2002 (1.6 %) and 2007-2010 (0.8 %) in US [8-10].. Considering high heterogeneity, subgroup analysis of different study year ranges showed overall decreasing trend of the rate with time. The decline appears to be attributed to government ...
THE EARTH A SPHERE. -- That the earth, too, is round is shown thus. The signs and stars do not rise and set the same for all men everywhere but rise and set sooner for those in the east than for those in the west; and of this there is no other cause than the bulge of the earth. Moreover, celestial phenomena evidence that they rise sooner for Orientals than for westerners. For one and the same eclipse of the moon which appears to us in the first hour of the night appears to Orientals about the third hour of the night, which proves that they had night and sunset before we did, of which setting the bulge of the earth is the cause ...
PMID 23838578] Genetic variants rs2393903 at 10q21.2 and rs6010620 at 20q13.33 are associated with clinical features of atopic dermatitis in the Chinese Han population ...
Some of the most famous and inspiring Asian men in this world also have non-Asian wives (women like me). Here are my five favorites.
This phase 1 study investigated Pharmacokinetics of apatinib in healthy Caucasian, Japanese and Chinese subjects following a single-dose administration to
Describes the nature and extent of residential provision for people with intellectual disabilities in 1991 in England, Scotland and Wales. Data from the OPCS Census suggest that: (1) substantial regional and national variation existed; (2) overall, the level of provision was significantly lower than Department of Health targets for 1991; (3) the majority of people with intellectual disabilities were living in relatively large-scale congregate care settings; (4) the majority of residents were younger and middle-aged adults; (5) young black men were significantly more likely to be placed in residential provision than their peers from other ethnic groups; (6) young Asian men, young Chinese/Other men and young Asian women were significantly less likely to be placed in residential provision than their peers from other ethnic groups; (7) rates of employment and marriage among residents were markedly lower than for the general population. The results are discussed in relation to national policy aims ...
Diabetes is known by the Singaporean Chinese as 糖尿病. In medical terms, it is a disease where the body has a high level of blood sugar...
Chinaman isnt racist - just unfashionable. Just like Oriental. After all, Chinese are from China, which is in the Orient. Its not like moron and idiot, which started out just like Chinaman, i.e. once upon a time they were literally, the word for that. The only reason idiot & moron became insults/slurs is because of everyone metaphorically comparing each other to idiots. But the thing is, people are always gonna want to call out stupid people, so the name for retarded or whatnot has to change every few years to keep one step ahead of people trying to use it to fuck with each other. Pretty sure retarded isnt the right word anymore either, and I dont even know the current term, but whoever decides these things should pick something so boring and bureaucratic/totalitarian-sounding that nobody even wants to use it as a slur - like differently abled - that was a good one. Whereas nobody is looking to call their non-Chinese friends Chinese, or call attention to Chinese people. Youre ...
Chinaman isnt racist - just unfashionable. Just like Oriental. After all, Chinese are from China, which is in the Orient. Its not like moron and idiot, which started out just like Chinaman, i.e. once upon a time they were literally, the word for that. The only reason idiot & moron became insults/slurs is because of everyone metaphorically comparing each other to idiots. But the thing is, people are always gonna want to call out stupid people, so the name for retarded or whatnot has to change every few years to keep one step ahead of people trying to use it to fuck with each other. Pretty sure retarded isnt the right word anymore either, and I dont even know the current term, but whoever decides these things should pick something so boring and bureaucratic/totalitarian-sounding that nobody even wants to use it as a slur - like differently abled - that was a good one. Whereas nobody is looking to call their non-Chinese friends Chinese, or call attention to Chinese people. Youre ...
The Chinese Exclusion Act (1882) was a US law that shut off all immigration of the Chinese race to the US - except for scholars, merchants, diplomats and professionals. Chinese people already in the US had to carry ID, even citizens. It is where the American idea of illegal aliens comes from, the beginning of…
Analysis of ERBB4 mutations and expression in japanese patients with lung cancer.: Only the kinase domain of ERBB4 has been analyzed in East Asian populations,
... This is a group for Chinese Adults to view and post photos, leave messages and arrange for other fun and adventures. Please add your two cents. yahoo.com/group/Indian-Adults yahoo.com/group/Pakistani-AdultsAsian Personals
Consistent with previous descriptions, our results show that the African population is the most diverse in terms of the number of variants expected to exist, the Asian populations the least diverse, with the European population in-between. In addition, our results show a clear distinction between the Chinese and the Japanese populations, with the Japanese population being the less diverse. To find all common variants (frequency at least 1%) the number of individuals that need to be sequenced is small (∼350) and does not differ much among the different populations; our data show that, subject to sequence accuracy, the 1000 Genomes Project is likely to find most of these common variants and a high proportion of the rarer ones (frequency between 0.1 and 1%). The data reveal a rule of diminishing returns: a small number of individuals (∼150) is sufficient to identify 80% of variants with a frequency of at least 0.1%, while a much larger number (> 3,000 individuals) is necessary to find all of ...
Libraries, Committee on East Asian (1981) "Notice on Membership," Journal of East Asian Libraries: Vol. 1981 : No. 66 , Article 11 ...
A functional variant in alcohol dehydrogenase 1B (ADH1B) is protective in people of European and Asian descent, and a different functional variant in the same gene is protective in those of African descent ...
Google is continuing to test new strategies in China after the U.S. search giant released its first mini program for WeChat, the countrys hugely popular messaging app. WeChat is used by hundreds of millions of Chinese people daily for services that stretch beyond chat to include mobile payments, bill paying, food delivery and more. Tencent, […]
Indian American Rajeev Majumdar sworn in as Washington State Bar Associations new president-- the first state bar president of South Asian descent.