Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic

Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the ...

Results: Consistent with previous reports, we found that the expression of TETs was decreased in various melanoma cell lines. In contrast, the expressions of sodium-dependent vitamin C transporters (SVCTs) were down-regulated in cell lines derived from melanoma metastases. Treatment of vitamin C at the physiological level (0.1 mM) promoted the content of 5hmC in melanoma cell lines derived from different stages toward the level of healthy melanocytes, which was comparable to the effect of overexpressing TET2. Vitamin C treatment decreased the malignancy of metastatic A2058 cells by inhibiting migration and anchorage-independent growth, while not exerting any effect on the rate of proliferation. Further, vitamin C treatment caused alterations in genome-wide transcriptions shown by RNA-seq, predominantly in ArhGAP30 and genes involved in extracellular matrix remodeling, which could underlie the decreased malignant phenotypes ...

Vitamin C (ascorbic acid): Find the most comprehensive real-world treatment information on Vitamin C (ascorbic acid) at PatientsLikeMe. 1216 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, attention deficit/hyperactivity disorder, bipolar II disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Vitamin C (ascorbic acid).

Vitamin C (ascorbic acid): Find the most comprehensive real-world treatment information on Vitamin C (ascorbic acid) at PatientsLikeMe. 1216 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Vitamin C (ascorbic acid).

Malaria is one of the most important tropical infectious diseases. Despite the fact that it is a completely preventable disease, a staggering 3.4 billion people continues to be at risk of the disease globally with 1.2 billion people at high risk particularly in high endemic and predominantly developing countries. In 2012, malaria was responsible for the death of approximately 482,000 under-five children. In Nigeria, Plasmodium falciparum malaria is responsible for around 60% of the out-patient visits to health facilities, 30% of childhood death, 25% of death in children under one year and 11% of maternal deaths. This study was carried out to determine the effect of Plasmodium falciparum parasitaemia on the serum ascorbic acid level of 60 malaria parasitized children of African descent aged 6 month-5 years visiting the children emergency unit and paediatric unit of Sokoto State Specialist Hospital in Sokoto, North Western, Nigeria. Controls included 30 non-parasitized children. Serum vitamin C ...

In the present study, we evaluated the effect of systemic administration of vitamin C on the healing of aneurysms embolized with platinum coils. Our results suggest that systemic vitamin C supplementation does not improve the long term histological healing of rabbit aneurysms following platinum coil embolization, as evidenced by lack of cellularity and fibrosis in the aneurysm cavity as well as dearth of neointimal coverage at the neck of the aneurysm. These negative results were found even though adequate levels of vitamin C were achieved in both test groups. Thus clinical trials of vitamin C to improve coil stability likely are not warranted.. The dose of vitamin C was selected based on our preliminary dose escalation study where four groups of aneurysms were purposely loosely packed with coils (packing density ,25%) and animals in each group were fed a diet containing 0, 866, 1732 and 4330 ppm vitamin C, respectively, for 12 weeks. These parts per million correspond to 0, 40, 80 and 200 mg of ...

This study aimed to verify the performance of xylanase and its interaction with oxidants agents (glucose oxidase and ascorbic acid) on the quality of whole wheat bread. The experiment was based on a central composite rotational design and the Response Surface Methodology was used to analyze the results. None of the xylanase, glucose oxidase or ascorbic acid concentrations within the studied range led to a significant difference in the specific volume. The highest moisture content and the lowest firmness values were reported in the bread with lower and intermediate levels of xylanase and larger amounts of glucose oxidase and ascorbic acid. This effect was observed mainly at the end of the storage period. A minimum amount of xylanase (from 33 to 63 EDX kg-1 flour) showed to be essential for obtaining best results. Levels of ascorbic acid above 63mg kg-1 and glucose oxidase above 91 SRU kg-1 proved to be necessary to offer the beneficial effect of xylanase. © 2016, Universidade Federal de Santa ...

Dehydroascorbic acid has been used as a vitamin C dietary supplement.[8] As a cosmetic ingredient, dehydroascorbic acid is used to enhance the appearance of the skin.[9] It may be used in a process for permanent waving of hair[10] and in a process for sunless tanning of skin.[11] In a cell culture growth medium, dehydroascorbic acid has been used to assure the uptake of vitamin C into cell types that do not contain ascorbic acid transporters.[12] As a pharmaceutical agent, some research has suggested that administration of dehydroascorbic acid may confer protection from neuronal injury following an ischemic stroke.[7] The literature contains many reports on the antiviral effects of vitamin C,[13] and one study suggests dehydroascorbic acid has stronger antiviral effects and a different mechanism of action than ascorbic acid.[14] Solutions in water containing ascorbic acid and copper ions and/or peroxide, resulting in rapid oxidation of ascorbic acid to dehydroascorbic acid, have been shown to ...

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Ascorbic acid is an essential nutrient involved in collagen formation, and its deficiency is associated with abnormal bone development. To examine the relation of ascorbic acid to bone mineral density and the prevalence of self-reported fractures, the authors analyzed data collected from 13,080 adults enrolled in the Third National Health and Nutrition Examination Survey (NHANES III) during 1988-1994. Because they identified three-way interactions among smoking, history of estrogen use, and dietary and serum ascorbic acid in postmenopausal women, they analyzed these relations stratified by smoking and estrogen use. Dietary ascorbic acid intake was independently associated with bone mineral density among premenopausal women (p = 0.002). Among men, serum ascorbic acid was associated in a nonlinear fashion with bone mineral density (p , 0.05), and dietary ascorbic acid intake was associated in a nonlinear fashion with self-reported fracture (p = 0.05). Among postmenopausal women without a history ...

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Dr. Pauling was a proponent of high-dose vitamin C as a preventive and treatment for many conditions, from colds to cancer. However, the majority of evidence has demonstrated that Dr. Paulings claims are not supported: Vitamin C supplementation neither prevents nor treats cancer. (Dr. Pauling felt that vitamin C didnt cure cancer, only that it stopped cancer from spreading.) Further, it is generally accepted that vitamin C supplementation does not treat colds, but it may reduce cold incidence in individuals exposed to extreme physical exercise.. Vitamin C has little potential for harm. Kidney stones in people with too much oxalate is one exception. Although one study showed vitamin C increased risk of heart disease and death in women with diabetes, I think this is not likely to be a true risk.. A fair summary of vitamin C, with a hundred references, can be found at https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/.. The data on multivitamins (as opposed to just vitamin C) are ...

Background. Vitamin C is associated with lower levels of high-sensitivity C-reactive protein (hsCRP), an inflammatory biomarker that predicts cardiovascular disease. However, whether low vitamin C intake is associated with hsCRP and cardiac event-free survival in patients with heart failure (HF) has not been examined.. Purpose. We hypothesized that patients with low vitamin C intake would have higher risk for elevated hsCRP and cardiac events than those with adequate intake of vitamin C.. Method. A total of 212 patients with HF (age 61±12 years, 34% female, 45% NYHA class III/IV) provided blood to measure serum hsCRP and were divided into 2 groups using 3mg/l of hsCRP as a cut-point. Patients completed a 4-day food diary verified with a registered dietitian. Nutrition Data System software program was used to determine intake of vitamin C. Adequacy of vitamin C intake was determined using formulas from the Institute of Medicine. Patients were followed for 1 year to determine time to first event ...

Introduction:. It has been over 40 years since Linus Pauling wrote the book, Vitamin C and the Common Cold. Dr. Pauling based his opinion on several studies that showed vitamin C was very effective in reducing the severity of symptoms, as well as the duration of the common cold. Since that time, the research has been very controversial. A new study adds another strong argument that vitamin C supplementation does in fact, produce the results that Pauling promoted.. Background Data:. Over 30 clinical trials involving 11,350 study participants have been designed to judge the effectiveness of vitamin C in the prevention or treatment of the common cold. While the results from individual studies may be mixed, when the results from higher quality studies are pooled researchers have concluded that vitamin C can be quite beneficial in reducing the risk of developing a cold. This conclusion especially applies to individuals in high stress situations. Vitamin C supplementation may also reduce the duration ...

Molecular Plant-Microbe Interactions 18:644-651...Sujatha Subramoni and Ramesh V. Sonti...© 2005 The American Phytopathological Society...Xanthomonas oryzae pv. oryzae causes bacterial leaf blight, a serious disease of rice. A mutation was isolated in the ferric uptake regulator (fur) gene of X. oryzae pv. oryzae and it was shown to result in the production of siderophores in a constitutive manner. The fur mutant is hypersensitive to...

Vitamin C concentrations in the brain exceed those in blood by 10-fold. In both tissues, the vitamin is present primarily in the reduced form, ascorbic acid. We identified the chemical form of vitamin C that readily crosses the blood-brain barrier, and the mechanism of this process. Ascorbic acid was not able to cross the blood-brain barrier in our studies. In contrast, the oxidized form of vitamin C, dehydroascorbic acid (oxidized ascorbic acid), readily entered the brain and was retained in the brain tissue in the form of ascorbic acid. Transport of dehydroascorbic acid into the brain was inhibited by d-glucose, but not by l-glucose. The facilitative glucose transporter, GLUT1, is expressed on endothelial cells at the blood-brain barrier, and is responsible for glucose entry into the brain. This study provides evidence showing that GLUT1 also transports dehydroascorbic acid into the brain. The findings define the transport of dehydroascorbic acid by GLUT1 as a mechanism by which the brain ...

Several lines of evidence suggested that antioxidants might play a protective role against high-risk human papillomavirus (hrHPV) infection and cervical cancer. However, the effect of combined intake of antioxidants has not been investigated thus far. The current cross-sectional study aimed to understand the relationship between dietary antioxidant intake and the risk of high-risk HPV (hrHPV) infection among 251 Italian women with normal cervical cytology. Women were tested for hrHPV using the Digene HC2 HPV DNA Test. Dietary antioxidant intakes were assessed using a semi-quantitative food frequency questionnaire, and a Composite Dietary Antioxidant Index (CDAI) was constructed on the basis of zinc, selenium, manganese, vitamin A, vitamin C, vitamin E, carotenoid, and flavonoid intake. Logistic regression analysis was used to assess odds ratio (OR) and 95% confidence interval (95% CI) for the associations of antioxidant intakes or CDAI with hrHPV status, adjusting for age, smoking status, body mass

Ascorbic acid (vitamin C) is an essential micronutrient with evidence supporting its role in bone formation, tissue repair, and collagen production. Its clinical importance to the field of orthopaedic surgery has yet to be fully defined. Several observational studies have shown improved bone density and reduced hip fracture risk with supplementation. Its effect on bone fracture and soft tissue injury has been promising in animal models, but is not adequately studied in human trials. Results have been mixed concerning its role in chondroprotection and osteoarthritis treatment. Evidence suggesting reduced incidence of complex regional pain syndrome following distal radius fracture when treated with adjuvant ascorbic acid has prompted much debate but has received an endorsement of moderate support from the American Academy of Orthopaedic Surgeons. Given its potential benefits, low cost, and safety profile, ascorbic acid supplementation warrants consideration by orthopaedic surgeons in the treatment ...

New research indicates that Vitamin C may be critical to maintaining good eye health and could be protective for those at risk of glaucoma.. The study done by Oregon Health & Science University indicates that Vitamin C may be needed for correct functioning of retinal cells.. The study, published in the Journal of Neuroscience, found that cells in the central nervous system need to be bathed in Vitamin C and because the retina is part of the central nervous system, there is likely an important role for Vitamin C.. Retinal cells share some characteristics with brain cells, one of which is special receptors called GABA-type receptors that help manage the rapid transfer of information between cells. The research shows that in retinal cells these receptors stop functioning properly if there is insufficient Vitamin C.. This new research used goldfish retinas which the researchers claim have the same overall biological structure as human retinas.. Dr Peter Hadden, Refractive-Cataract Surgery and ...

The ascorbate transporters SVCT1 and SVCT2 are necessary for maintaining intracellular ascorbate concentrations generally in most cell types. 1 / 2 of SVCT1 knockout mice usually Hordenine supplier do not survive to weaning. These results confirm the significance both of mobile ascorbate and of both transport protein as crucial to preserving intracellular ascorbate. gene and maps to chromosome 5q31.2C31.3 (Stratakis and maps to chromosome 20p12.2C12.3 (Hogue and Ling, 1999; Stratakis oocyte appearance studies demonstrated that neither isoform provides appreciable affinity for isoascorbate or DHA (Rumsey oocytes (Tsukaguchi (Berger and Hediger, 2000), but develop it when put into lifestyle (Siushansian up-regulation from the SVCT2 continues to be demonstrated within the peri-infarct section of rodent human brain following ischaemic damage (Berger oocytes (Eck em et al /em ., 2007). Following studies uncovered that several individual polymorphic variants portrayed in oocytes do in fact have got ...

TY - JOUR. T1 - The role of ascorbic acid transporter in the lens of streptozotocin-induced diabetic rat. AU - Nakazawa, Yosuke. AU - Oka, Mikako. AU - Bando, Masayasu. AU - Inoue, Takashi. AU - Takehana, Makoto. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Ascorbic acid (AA) is found in high concentrations in the lens and protects the lens from photochemical events such as photo-oxidation. Diabetes reduces the concentration of AA in the lens, and it has been suggested that AA supplementation may rescue lens AA in diabetic patients. In the present study, the effects of dietary supplementation with AA were studied to assess changes in AA concentration and AA transporter expression in the lenses of streptozotocin (STZ)-induced diabetic rats. AA was lower in the aqueous humors and lenses of diabetic rats than in control rats, and low AA levels could be normalized with dietary AA supplementation. The sodium-dependent ascorbic acid transporter2, SVCT2, is transporter of AA, and glucose transporter 1 and 3 ...

The experiment was carried out with the aim of investigating the effect of an antioxidant ascorbic acid on erythrocyte osmotic fragility of pigs transported by road for 4 h during the harmattan season. 16 pigs administered with ascorbic acid at the dose of 250 mg/kg per os and individually served as experimental animals and 13 others administered orally with sterile water were used as control animals. The animals were then transported for 4 h at a speed of 40 - 50 km/h covering a distance of 140 km. Blood samples for erythrocyte osmotic fragility determination which was done using standard procedure, were taken early in the morning a day before transportation, immediately after and a week after transportation. Erythrocyte osmotic fragility decreased significantly (P , 0.05) at NaCl concentration of 0.85, 0.80 and 0.70% in both experimental and control pigs following road transportation and the difference in the post-transportation values was higher (P , 0.05) in ...

A novel glassy carbon electrode (GCE) modified with carbon-spheres has been fabricated through a simple casting procedure. The modified GCE displays high selectivity and excellent electrochemical catalytic activities towards dopamine (DA), serotonin (5-HT), and ascorbic acid (AA). In the co-existence system, the peak separations between AA and DA, DA and 5-HT, and AA and 5-HT are large up to 230, 180, and 410 mV, respectively. Differential pulse voltammetry (DPV) has been employed to simultaneously detect DA, 5-HT, and AA, and the linear calibration curves for DA, 5-HT, and AA are obtained in the range of 20.0-150.0 μM, 40.0-750.0 μM and 300.0-2,000.0 μM with detection limits (S/N = 3) of 2.0 μM, 0.7 μM and 0.6 μM, respectively. The proposed electrode has been applied to detect DA, 5-HT, and AA in real samples using standard addition method with satisfactory results.

Abstract. There is little information available concerning the possible effects of ascorbic acid on glucose-6-phosphate dehydrogenase (G-6-PD) - deficient eryt

The aim of this study is to extend previous findings that nutritional supplementation or dietary modification can ameliorate exercise-induced bronchoconstriction. It has been shown in separate studies that fish oil and ascorbic acid (vitamin C) individually protect against EIB by improving pulmonary function and reducing airway inflammation. The main aim of this study is to determine the comparative and additive effects of fish oil and ascorbic acid supplementation on EIB and airway inflammation in asthmatic individuals ...

It turns out that scurvy and vitamin C deficiency is still around these days. Scurvy is a disease resulting from a lack of vitamin C. Most animals can synthesize vitamin C, but not humans. We must eat foods containing vitamin C to get the vitamin. Vitamin C deficiency results in defective formation of collagen and connective tissues (in our bones, skin, tendons, muscles), and symptoms may include weakness, feeling tired, curly hair, sore arms and legs, bruising, bleeding gums, and impaired wound healing.. A recent small Australian study looked at diabetic persons with chronic foot wounds (foot ulcers that didnt heal after several months). Their vitamin C levels were tested and if found to be low, then they were given vitamin C supplements of 500 or 1000 mg daily, and the result was that within 2 to 3 weeks the wounds were healed. The one person with a zinc deficiency was given 50 mg daily of zinc supplement and that wound also promptly healed.. Treatment of scurvy is by taking vitamin C ...

1.1 INTRODUCTION ascorbic acid (vitamin C) is a water- soluble vitamin found particularly in citrus fruits and green vegetables, it is necessary for normal growth and development of an individual. It is an antioxidant that helps maintain the connective tissue, protein collagen, protects the body against infection and helps iron absorption (Sizer, et al., 1997). Food with a naturally high vitamin C contents are fruits such as berries, lychee, papaya and citrus fruits, vegetables like Brussels sprouts, cauliflower, cabbage, sweet pepper, and herb like parsley, sorrel and chives (Anses, 2012).. Vitamin C is defined as the generic term for all compounds exhibiting the biological activity of L- ascorbic acid. Ascorbic acid is the principal biologically active form but L- dehydroascrobic acid is an oxidation product which also exhibits biological activity. Vitamin C is required for the prevention of scurvy and maintenance of healthy skin, gums and blood vessels. It functions in collagen formation, ...

Metabolic syndrome (MetS) is a constellation of cardiometabolic risk factors, which together predict increased risk of more serious chronic diseases. We propose that one consequence of dietary overnutrition is increased abundance of Gram-negative bacteria in the gut that cause increased inflammation, impaired gut function, and endotoxemia that further dysregulate the already compromised antioxidant vitamin status in MetS. This discussion is timely because healthy individuals are no longer the societal norm and specialized dietary requirements are needed for the growing prevalence of MetS. Further, these lines of evidence provide the foundational basis for investigation that poor vitamin C status promotes endotoxemia, leading to metabolic dysfunction that impairs vitamin E trafficking through a mechanism involving the gut-liver axis. This report will establish a critical need for translational research aimed at validating therapeutic approaches to manage endotoxemia-an early, but ...

4 In our opinion, Vitamin C is not a miracle cancer cure, as vitamin C by itself is a rather weak cancer killer. Intravenous Vitamin C (IV/C), however, can be potent. Most patients on chemo therapy do better taking intravenous vitamin C after chemo. High dosages (200 grams) are required for IV/C in conjunction with a no-carb (ketogenic) diet. We believe that other add-on supplements, those mentioned in the Hickey/Roberts book CANCER: NUTRITION AND SURVIVAL, are important to increase vitamin Cs effectiveness killing cancers. These adjuncts include alpha lipoic acid, vitamin k3. New: Maitake DFraction mushroom, may be effective combined with Vitamin C ...

This study was designed to elucidate the effect of ascorbic acid on salivary total antioxidant capacity in smokers. In this single blind crossover clinical trial, the whole unstimulated saliva of 30 smokers, who were randomly divided into two groups, was collected. In the first phase after the saliva collection, one group of patients took 500 mg of vitamin C powder, for 3 weeks. Then, saliva of all patients was collected. After a one-week wash-out period, vitamin C was given to the other group. The collection of saliva was done after 3 weeks. Total antioxidant capacity was measured. Statistic evaluation was performed by Repeated Measured ANOVA, Independent sample t-test and Covariate test. The mean of total antioxidant capacity with and without using vitamin C was 0.511 ± 0.155 (U/mL) and 0.555 ± 0.171 (U/mL), respectively. This variability was not significant (p = 0.605). Oxidative stress from cigarette smoke was not decreased significantly with using vitamin C.

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Although vitamin C may be used in some circles as a folk remedy for menstrual problems, its ties to heavy bleeding during menstruation are unclear. Most...

TY - JOUR. T1 - Encapsulation of ascorbic acid promotes the reduction of Maillard reaction products in UHT milk. AU - Troise, Antonio Dario. AU - Vitiello, Daniele. AU - Tsang, Catherine. AU - Fiore, Alberto. PY - 2016/6/1. Y1 - 2016/6/1. N2 - The presence of amino groups and carbonyls renders fortified milk with ascorbic acid particularly susceptible to the reduction of available lysine and to the formation of Maillard reaction products (MRPs), as Nε-(Carboxyethyl)-L-lysine (CEL), Nε-(Carboxymethyl)-L-lysine (CML), Amadori products (APs) and off-flavors. A novel approach was proposed to control the Maillard reaction (MR) in fortified milk: ascorbic acid was encapsulated in a lipid coating and the effects were tested after a lab scale UHT treatment. Encapsulation promoted a delayed release of ascorbic acid and a reduction in the formation of MRPs. Total lysine increased up to 45% in milk with encapsulated ascorbic acid, while reductions in CML, CEL and furosine ranged from 10% to 53% compared ...

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Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimers disease and ischemic stroke. Ascorbic acid (vitamin C) has also been shown to protect cerebral tissue in a variety of experimental conditions, which has been attributed to its antioxidant capacity. In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other COX inhibitors (SC-58125 and indomethacin). The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase ...

TY - JOUR. T1 - L-ascorbic acid and alpha-tocopherol attenuates liver ischemia-reperfusion induced of cardiac function impairment. AU - Hsu, C. C.. AU - Wang, J. J.. PY - 2012/5. Y1 - 2012/5. N2 - Objectives: The Pringle maneuver is a surgical procedure to minimize hemorrhage during hepatectomy, which however, can induce production of reactive oxygen species causing remote organ injury. We sought to study the impact of the Pringle maneuver on cardiac function as well as the protective effects of L-ascorbic acid and α-tocopherol pretreatments. Methods: Rats were divided into four study groups: L-ascorbic acid (60 mg/kg/d) or α-tocopherol (200 mg/kg/d), and surgical interventions (Sham-operated or liver ischemia-reperfusion [I/R]). Liver ischemia was performed by clamping the hepatic artery and portal vein for 30 minutes, followed by reperfusion by releasing the clamps for 2 hours. Cardiac function was evaluated by a high-fidelity pressure-volume catheter positioned in the left ventricle. ...

β-Hydroxy β-methylbutyric acid (HMB), also known as β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement.. Due to its acidic nature, citrus fruits that have abundant vitamin C are usually not prescribed in heartburn as the acid may exacerbate the effects of the reflux. However. It is strictly not recommended for pregnant woman to consume any part of papaya in any form as it can cause abortion or birth defects in the baby. Papaya.. Current Illinois Link Cardholders. There are two ways to manage your Illinois Link Account. 1. Illinois Link Card Website; Illinois Link Card Website - For language.. The surprising new food rules to banish acid reflux for good: Cheese and pasta will help, but DONT touch tomatoes and mint tea. Acid reflux affects millions.. does ascorbic acid cause acid reflux Biscuits. does ascorbic acid cause acid reflux kgeh that discuss about the effects of pantoprazole works fast and.. Effects of Ascorbic Acid on ...

RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Ascorbic acid may help melphalan work better by making cancer cells more sensitive to the drug. Giving bortezomib together with ascorbic acid and melphalan may kill more cancer cells.. PURPOSE: This phase II trial is studying how well giving bortezomib together with ascorbic acid and melphalan works in treating patients with newly diagnosed multiple myeloma. ...

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Two retrospective studies (one on septic shock and the other on severe pneumonia) reported that combined administration of vitamin B1, C, and hydrocortisone was associated with improved clinical outcomes [13,14]. However, two recent studies demonstrated no such clinical benefits of early vitamin C and thiamine administration in patients with septic shock in emergency department [15,16]. Vitamin C monotherapy was ineffective to improve clinical outcome in patients with severe sepsis or septic shock receiving mechanical ventilation [29]. The clinical implication of combined vitamin B1 and C administration and the optimal dose remains undefined. The clinical data of vitamin B1 and C supplementation on patients with sepsisrelated ARDS are still lacking. The present study evaluated the clinical benefit of vitamin B1 and C supplementation in patients with sepsis-related ARDS. There were no significant differences in mortalities between the supplementation and control groups. The ventilator-free and ...

Natural News) Just like clockwork, the dreaded common cold comes around every year, causing runny nose, persistent coughing and misery. But does it really have to be this way? According to recent studies, it doesnt.. A study published in the journal Nutrients found that vitamin C is the key to recovering from the symptoms of the common cold. A researcher from the University of Helsinki in Finland discovered that a high dose of vitamin C can potentially reduce the duration of the common cold. Vitamin C, also known as ascorbic acid, is known to relieve and prevent bacterial and viral infections among different animal species. Its effects on human infections are similar to those found in animal studies.. Dr. Harri Hemila, the author of the study, reviewed the findings of two trials that focused on the effects of vitamin C doses during a common cold infection. In the first trial, two different study groups received 3 g (3,000 mg) of vitamin C per day. The third group received 6 g (6,000 mg) the ...

Abstract: Amino acids and their derivatives are useful as models of specific aspects of more complex proteins in aqueous solution. In this paper, densities and viscosities of L-threonine in glucose-water, sucrose-water and L-ascorbic acid-water mixed solvents have been measured at 298.15 K by an oscillating-tube densimeter and a viscositymeter . Limiting partial molar volume, transfer partial molar volume, number of hydration and viscosity B-coefficients of L-threonine have been calculated. The viscosity B-coefficients and the numbers of hydration of L-threonine mixed solvent vary with mass concentration of sugar or L-ascorbic acid. The transfer partial molar volumes from water to sugar-water or L-ascorbic acid-water mixtures have been obtained and discussed in terms of the structural hydration interaction model. The results indicate that the transfer partial molar volumes and viscosity B-coefficients of L-threonine increase with increasing of the mass concentration of sugar or L-ascorbic acid, ...

Vitamin C is one of the stars of skincare. Vitamin C is needed to make collagen that strengthens skin, muscles, and blood vessels and to ensure proper wound healing. Severe injury issues to increase vitamin C demands and vitamin c deficiency cause delayed healing.. Preliminary humans studies recommend that vitamin C supplementation in non-deficient people can speed healing of different varieties of wounds and trauma, including operation, minor scratches, herniated intervertebral discs, and skin ulcers. ...

The exact mechanism by ascorbic acid may offer nephroprotection is unclear, but it has been widely used due to its antioxidant property. ROS-induced oxidative stress and renal vasoconstriction have been implicated in the etiology of CI-AKI. Hydroxyl radical (OH·) is one of many free radicals that can cause oxidative stress. The Haber Weiss/Fenton reaction cycle governs the generation of OH· from hydrogen peroxide (H2O2) and superoxide radical (O2·−), with reduction of ferric to ferrous by O2·−, ferrous acting as a catalyst for this cycle. Ascorbate is an efficient scavenger of ROS such as O2·−, H2O2, and OH· can therefore reduce the oxidative stress (1). Being a reducing agent, ascorbic acid has the ability to reduce ferric to ferrous, thus potentially promoting the generation of ROS and acting as a pro-oxidant. However, this pro-oxidant effect has been demonstrated mainly in vitro; corresponding in vivo data has been inconsistent (2,20,21). Radox-active free iron is required for the ...

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Abstract: : Purpose: To determine:1. The presence of sodium-dependent vitamin C transporter 1 (SVCT1) and 2 (SVCT2) in mammalian lens and 2. The effects of glucose, H2O2 and agonists for PKA and PKC on ascorbic acid (ASA) transport in lens. Methods: RT-PCR and immunostaining were performed to identify lens SVCT1 and SVCT2. Regulation of ascorbic acid transporters was studied under hyperglycemic conditions. Glucose or ascorbic acid uptake by intact guinea pig and rabbit lenses was determined by incubation in 3H labeled 2-deoxyglucose, and/or 14C labeled ascorbic acid. PKA was activated using membrane permeant cAMP and PKC using PMA. Results: RT-PCR of lens total RNA and immunostaining of lens sections showed the presence of SVCT1 and SVCT2 in mouse and rabbit lens epithelium and fiber cells; however, expression of SVCT2 was higher than that of SVCT1. SVCT 1 and SVCT2 were localized more to the apical side of the lens epithelium. In fiber cells, the SVCTs showed uniform distribution. In lenses ...

Abstract: : Purpose: Exfoliation syndrome (XFS) is a disorder involving aberrant extracellular matrix production. The principal ocular cells involved in exfoliation material synthesis are closely associated with the aqueous humor. High ascorbate concentration in the aqueous humor has been known for decades. We have evaluated the levels of ascorbic acid in the aqueous humor of patients with XFS in comparison with normal age-matched control patients. Methods: Aqueous humour samples were obtained at the beginning of phacoemulsification cataract surgery. Eighty aqueous samples, 40 from cataract patients with XFS and 40 from age matched cataract patients without XFS have been analysed. Ascorbic acid concentration in the aqueous was determined by a microplate assay method. Protein concentration was also measured in the same samples. Results: The mean concentration of ascorbic acid in the aqueous humor from patients with XFS (0,86 ± 0,43 mM) was significantly lower than that measured in the aqueous ...

Synonyms for Ascorbic acid deficiency in Free Thesaurus. Antonyms for Ascorbic acid deficiency. 23 synonyms for scurvy: contemptible, mean, bad, low, base, rotten, sorry, worthless, shabby, vile, low-down, pitiful, abject, despicable, dishonourable.... What are synonyms for Ascorbic acid deficiency?

The Kuopio ischaemic heart disease risk factor study is a population study designed to investigate risk factors for cardiovascular diseases, atherosclerosis, and related outcomes in men from eastern Finland.18 The baseline examinations were carried out between March 1984 and December 1989. The study sample included 3235 eligible men aged 42, 48, 54, or 60 at the baseline examination; 2682 (82.9%) participated. Men with symptomatic coronary heart disease (n = 92) or ischaemia on maximal exercise testing (n = 359),19 or both (n = 585), were excluded from the current analyses. Of the remaining 1646 men, 1605 had data on plasma ascorbate concentration at baseline.. The examination protocol and measurements have been described.10 11 12 13 Plasma ascorbate concentrations were determined by a chromatographic method in deep frozen samples, which were stabilised in 5% metaphosphoric acid immediately after sampling.20 The coefficient of variation between 12 batches was 7.2%.20. Plasma ascorbate ...

It has been shown that vitamin C (VC) is transported at synaptic boutons, but how this occurs has not been elucidated. This study investigates the role of the sodium-dependent vitamin C transporter-2 (SVCT2) in transporting VC at the cortical nerve terminal. Immunostaining of cultured mouse superior cervical ganglion cells showed the SVCT2 to be expressed in presynaptic boutons, colocalizing with the vesicular monoamine transporter-2 and the norepinephrine transporter. Immunoblotting of enriched cortical synaptosomes demonstrated that the SVCT2 was enriched in presynaptic fractions, confirming a predominantly presynaptic location. In crude synaptosomes, known inhibitors of SVCT2 inhibited uptake of VC. Furthermore, the kinetic features of VC uptake were consistent with SVCT2-mediated function. VC was also found to efflux from synaptosomes by a mechanism not involving the SVCT2. Indeed, VC efflux was substantially offset by reuptake of VC on the SVCT2. The presence and function of the SVCT2 at ...

Buffered Vitamin C as K/Mg Ascorbate, for those who would like to supplement their diet with additional Vitamin C without increasing stomach acidity. We have combined fully reacted, non-acidic potassium/magnesium ascorbate with lemon bioflavonoids and hesperidin complex. Excellent for children and adults alike. pH=6.0 Ingredients: Serving size: 1 capsule Vitamin C (as Potassium Magnesium Ascorbate and Ascorbyl Palmitate) 500 mg. Potassium (as Potassium Ascorbate) 50 mg. Magnesium (as Magnesium Ascorbate) 20 mg. Lemon Bioflavinoids (includes 50 mg. of Rutin and 50 mg. of Hesperidin) 120 mg. Other ingredients: gelatin capsule Suggested Use: 1 capsule daily as a dietary supplement, or as directed by a doctor. Preservative and Excipient-free

TY - JOUR. T1 - Manganese absorption in humans. T2 - The effect of phytic acid and ascorbic acid in soy formula. AU - Davidsson, Lena. AU - Almgren, Annette. AU - Juillerat, Marcel A.. AU - Hurrell, Richard F.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The absorption of manganese from soy formula was studied in adult volunteers by extrinsic labeling of test meals with 54Mn, followed by whole-body retention measurements for ≃ 30 d after intake. Eight subjects participated twice in each of the two studies, acting as his or her own control. Soy formula containing the native content of phytic acid was compared with a similar dephytinized formula: geometric mean manganese absorption increased 2.3-told from 0.7% (range: 0.2-1.1%) to 1.6% (range: 1.0-7.2%) (P , 0.01) with the dephytinized formula. In addition, the effect of the ascorbic acid content of the phytic acid-containing formula was investigated. Manganese absorption was not influenced by an increase in the ascorbic acid from 625 μmol/L (110 mg/L) ...

Although vitamin C deficiency and scurvy are generally considered as pure nutritional disorders, only a minority of the vitamin C concentration is determined by food intake. In the presence of transit

Health Freedom New Zealand would like to congratulate the Dairy Farming family featured on TV3s 60 minutes last night for insisting that their family member, Allan Smith, be treated with intravenous Vitamin C therapy - rather than accepting the medical fraternities decision to turn off his life support and let him die. Having been cured from Leukemia using natural products and high dose Vitamin C myself, says spokeswoman Nicola Grace, I am excited that finally the truth is coming out about natural cures for infectious diseases and cancer. Now that this simple, cheap and effective treatment is implicated in the spontaneous remission of what a team of specialists were convinced was a terminally fatal case of swine flu, as well as hairy cell leukaemia, it would be negligent to ignore and criminal to deny high dose intravenous Vitamin C for future swine flu and/or hairy cell leukaemia admissions she states. When the hospital interfered with the treatment, both by under-dosing and by withholding ...

BACKGROUND: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. OBJECTIVE: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. DESIGN: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (α- and β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. RESULTS: UCC risk decreased with higher concentrations of the sum

Foxp3 stability of vitamin C-treated induced-regulatory T cells (V-iTregs) is superior to that of conventional iTregs (C-iTregs). However, the role of V-iTregs in allograft rejection under vitamin C-deficient conditions, such as those seen in humans, remains unclear. We aimed to elucidate the role of vitamin C treatment on generation and maintenance of iTregs from gulo knockout (Gulo-KO) mice as well as wild type (WT) mice, and in vitro and in vivo suppressive effects of V-iTregs on heart allograft rejection in either Gulo-KO or WT recipient mice. Conversion efficiency of iTregs was similar between C- and V-iTregs in both WT and Gulo-KO mice. V-iTregs from WT or Gulo-KO mice showed better in vitro Foxp3 stability than C-iTregs, although there was no difference between WT V-iTregs and Gulo-KO V-iTregs. Furthermore, V-iTregs from WT or Gulo-KO mice suppressed in vitro T cell proliferation better than C-iTregs. Heterotrophic heart transplantation from BALB/c mice to WT or vitamin C-deficient ...

Vitamin C is a water-soluble vitamin and is not stored in the body in large quantities for prolonged periods of time. Since the human body cannot synthesize it, dietary intake of vitamin C on a regular basis is therefore necessary. Excess vitamin C is excreted in the urine thereby ensuring that the body has a total pool of about 1,500 milligrams (mg). Scurvy arises when a persons diet is deficient of vitamin C for about 3 months and the total body pool of vitamin C declines to levels below 350 mg.. The signs and symptoms associated with scurvy are largely due to the impaired synthesis of collagen. It is essentially the cement between cells that gives various tissues its firmness and strength. Weakening of these tissues, like the capillaries, leads to bleeding (hemorrhage), brittle bones and in children the normal growth of bone is affected. Iron absorption, immune function, the breakdown of cholesterol and formation of neurotransmitters are affected in scurvy thereby contributing to the ...

Neurological Benefits. The neurological benefits of vitamin C are profound and well-researched. This substance stimulates the production of a variety of enzymes involved in cognition. While the brain naturally produces these enzymes, it fails to produce them if you have a vitamin C deficiency.. As an antioxidant, vitamin C protects brain cells from the harmful effects of excessive stimulation. Oxidative stress leads to cell death, and vitamin C protects against oxidative stress in animal models.. Research has found that potassium channels play a role in depression. Vitamin C blocks potassium channels, which has antidepressive effects. A longitudinal study found that people who consumed adequate amounts of vitamin C were less likely to develop dementia. Since vitamin C is an antioxidant, it may also reduce the risk of Alzheimers disease.. Cardiovascular Benefits. Like other antioxidants, vitamin C appears to improve blood flow. Vitamin C deficiency increases your risk of atherosclerosis, so ...

As anyone with diabetes knows, with or without thick toenails, you have to always pay particular attention to your feet by wearing shoes that fit well and keeping your toenails clipped well. These tiny fish gnaw away at the dead putting breast milk on psoriasis leaving healthy, untouched skin beneath it. Figure 5: Changes in gut microflora composition after antibiotic treatment in adult versus neonatal antibiotic treated adult mice. I made sure to get good coconut water not the cola brands so i went with Sprouts health food store C20 100 coconut water with pulp. Sadly though is detrimental eczema pictures on chest research has eczema on face natural remedy moderate cases lotions gels lotions creams an ointment treatment this content.

Seventeen years after it was originally suggested, the photoreceptor protein cryptochrome remains the most probable host for the radical pair intermediates that are thought to be the sensors in the avian magnetic compass. Although evidence in favour of this hypothesis is accumulating, the intracellular interaction partners of the sensory protein are still unknown. It has been suggested that ascorbate ions could interact with surface-exposed tryptophan radicals in photoactivated cryptochromes, and so lead to the formation of a radical pair comprised of the reduced form of the flavin adenine dinucleotide cofactor, FAD*- , and the ascorbate radical, Asc*-. This species could provide a more sensitive compass than a FAD- tryptophan radical pair. In this study of Drosophila melanogaster cryptochrome and Erithacus rubecula (European robin) cryptochrome 1a, we use molecular dynamics simulations to characterize the transient encounters of ascorbate ions with tryptophan radicals in cryptochrome in order ...

Amakye-Anim, J., T. Lin, P. Hester, et al. (2000) Ascorbic acid supplementation improved antibody response to infectious bursal disease vaccination in chickens. Poultry Science 79:680-688. Azad, I., J. Dayal, M. Poornima, and S. Ali (2007) Supra dietary levels of vitamins C and E enhance antibody production and immune memory in juvenile milkfish, Chanos chanos (Forsskal) to formalin-killed Vibrio vulnificus. Fish & Shellfish Immunology 23:154-163. Carroll, R., K. Kovacs, and E. Tapp (1965) Protection against mercuric chloride poisoning of the rat kidney. Arzneimittelforschung 15:1361-1363. Feigen, G., B. Smith, C. Dix, et al. (1982) Enhancement of antibody production and protection against systemic anaphylaxis by large doses of vitamin C. Research Communications in Chemical Pathology and Pharmacology 38:313-333. Gage, J. (1975) Mechanisms for the biodegradation of organic mercury compounds: the actions of ascorbate and of soluble proteins. Toxicology and Applied Pharmacology ...

Why do we need Sodium Ascorbate?. The GLO Gene is absent in many people. Scientists believe that this happened around 60 million years ago. The absence of this gene makes us unable to biosynthesize the specific enzyme L- gulonolactone oxidase. This is an end-stage liver enzyme that bio-converts blood glucose to Ascorbate; without it, our bodies cannot produce any Ascorbate. In the long term, the lack of Ascorbate causes our bones to dissolve and teeth to fall out; in other words, sub-clinical scurvy and a tendency to develop cancer.. Ascorbic Acid is produced in large quantities in almost all animals, e.g. 6 grams a day in goat, or up to 100grams daily if the goat is stressed. But it is not the Ascorbic Acid our body requires, rather a SALT of Ascorbic Acid. A daily supplementation of Ascorbate several times a day is a simple way to make up for this genetic defect.. Robert F. Cathcart, MD another medical pioneer who has had great success with Ascorbate, successfully treating over 25,000 patients ...

Source: Beat Diabetes Naturally - The Best Foods, Herbs, Supplements, And Lifestyle Strategies To Optimize Your Diabetes Care. Attempts to prevent sorbitol accumulation with drugs have failed due to severe side effects. In contrast, vitamin C is able to accomplish what these drugs could not - safe and effective inhibition of sorbitol accumulation.. In one study in young adults with type I diabetes, baseline measurement of sorbitol in red blood cells were nearly double in these patients despite adequate dietary intakes of vitamin C. Vitamin C supplementation at a dosage of either 100 or 600 mg normalized sorbitol in red blood cells within 30 days. This correction of sorbitol accumulation was independent of changes in diabetic control as monitored by fasting glucose or hemoglobin A1C. In fact, overall diabetic control during the study was moderate to poor, indicating that the effect of vitamin C was not dependent on glucose concentration.. These results indicate that vitamin C may inhibit aldose ...

Consumption of plant flavonoids, antioxidants, and n-3 fatty acids is proposed to have many potential health benefits derived primarily through antioxidant and anti-inflammatory activities. This study examined the effects of 1,000 mg quercetin + 1,000 mg vitamin C (QC); 1,000 mg quercetin, 1,000 mg vitamin C, 400 mg isoquercetin, 30 mg epigallocatechin gallate, and 400 mg n-3 fatty acids (QFO); or placebo (P), taken each day for 2 wk before and during 3 d of cycling at 57% Wmax for 3 hr, on plasma antioxidant capacity (ferricreducing ability of plasma [FRAP], oxygen-radical absorbance capacity [ORAC]), plasma oxidative stress (F2-isoprostanes), and plasma quercetin and vitamin C levels. Thirty-nine athletes were recruited and randomized to QC, QFO, or P. Blood was collected at baseline, after 2 wk supplementation, immediately postexercise, and 14 hr postexercise. Statistical design used a 3 (groups) × 4 (times) repeated-measures ANOVA with post hoc analyses. Plasma quercetin was significantly ...

Vitamin C Deficiency (Scurvy):. Signs of scurvy include drooling, weight loss, hair loss or reluctance to move due to painful joints. Therapy is mainly Vitamin C supplementation. Correction of the diet to include daily Vitamin C sources is necessary. Supportive care (fluids, antibiotics, etc) may be needed in very ill patients. This is a common and preventable disease in this species.. → Dental Diseases:. Guinea pigs have constantly growing teeth, and may develop overgrown front teeth (incisors) or back teeth (molars) for a variety of reasons. Vitamin C deficiency (scurvy) can cause TMJ pain and lead to tooth overgrowth. Incisor overgrowth may be visible as long tusk-like projections from the mouth. Molar overgrowth (or molar infections) may cause drooling, chin staining, foul odor, and difficulty eating. Treatment of tooth problems often involves trimming the overgrown teeth back to normal length, extracting any infected teeth, correcting any other illness which may be contributing to the ...

The best food sources of vitamin C are the citrus fruits (oranges, lemons, limes, tangerines, and grapefruits). Other fruits with high amounts of vitamin C include camu camu berries, rosehips, acerola cherries, papayas, cantaloupes, and strawberries. The best vegetable sources are red and green peppers, garlic, onions, broccoli, Brussels sprouts, tomatoes, asparagus, parsley, dark leafy greens, cabbage, and sauerkraut. Vitamin C (ascorbic acid) may well be the most controversial of all the vitamins. Most of the medical establishment still objects to the use of megadoses of vitamin C for treatment of cancer, the flu, allergies, stress, adrenal fatigue, or just about anything else. All this negativity may be unwarranted, however, because there is a growing body of medical evidence supporting the use of vitamin C in very high doses.Vitamin C, and its closely related bioflavonoids, can be found in all citrus fruits and numerous other fruits and vegetables. In fact, vitamin C was first isolated from ...

Tamarind is rich in Vitamin C content which plays the role of a major vitamin in the body. Deficiency of vitamin C can give rise to several disorders including scurvy, gingivitis, connective tissue defects and many others. Vitamin C deficiency has also been linked with depression and fatigue. The high percentage of vitamin C available in tamarind not only provides protection from all these conditions but also helps in curing these conditions. So, if you think that your diet does not include sufficient vitamin C, using tamarind extract in your daily cooking can be the right way to fill in your daily vitamin C requirements.. ...

Like us, guinea pigs cant make vitamin C, but must obtain it from their diet. This makes them a good model for examining the effects of vitamin C deficiency.. In a recent study looking specifically at the effects of prenatal vitamin C deficiency, 80 pregnant guinea pigs were fed a diet that was either high or low in vitamin C. Subsequently, 157 of the newborn pups were randomly allocated to either a low or high vitamin C diet (after weaning), creating four conditions: high/high (controls); high/low (postnatal depletion); low/high (postnatal repletion); low/low (pre/postnatal deficiency). Only males experienced the high/low condition (postnatal depletion).. Only the postnatal depletion group showed any effect on body weight; no group showed an effect on brain weight.. Nevertheless, although the brain as a whole grew normally, those who had experienced a prenatal vitamin C deficiency showed a significantly smaller hippocampus (about 10-15% smaller). This reduction was not reversed by later ...

Vitamin C with Flavonoids 180 caps. Vitamin C with flavonoids optimizes the beneficial effects of vitamin C - including support of immune function - by replicating the way its found in nature.* Vitamin C (ascorbic acid) is a key antioxidant, helping protect cells throughout the body from free radical damage.* It plays an integral role in the production of cellular energy, and is essential for the proper metabolism of carbohydrates and the synthesis of fats and proteins.* Thornes Vitamin C with Flavonoids contains ascorbic acid and citrus flavonoids. The flavonoids are a mixture of naturally-occurring flavonoids, including rutin, hesperidin, and quercetin. And there is no corn starch contained in this supplement. Although ascorbic acid will work in the body without flavonoids, it works better when accompanied by flavonoid molecules, because the bioflavonoids spare vitamin C, thus providing greater antioxidant capacity.*. • Immune Support ...

The dangers of chlorination were first documented in the 1950s. During the Korean civil war, soldiers who were given chlorine tablets for their canteens developed severe cardiovascular diseases. A lot of soldiers died because of heart disease within the next ten years.. While you can do your best to avoid areas exposed to chlorine, an effective way to neutralize the toxic chemical is with ascorbic acid or vitamin C, since it chemically destroys chlorine. (Related: 7 Reasons why you should start eating more blueberries.). The reverse is also true since chlorine can destroy vitamin C. Since both chemicals cancel each other out, consuming more vitamin C than chlorine is crucial to neutralizing the latter.. One gram (g) of vitamin C can neutralize 100 gallons (gal) of water with one part per million (PPM) of chlorine. Take note that one PPM is standard for U.S. drinking water, but it can legally go up to four PPM chlorine.. While the naked eye cannot see the neutralization effect, as it is ...

In this study, fifteen commercial varieties, nine exotic genotypes, and three wild species of tomato grown in Eastern India were analyzed for variations in different phytochemicals viz. ascorbic acid, lycopene, total carotenoids, total phenolics content and total antioxidant capacity. Selected genotypes showed significant differences with respect to phytochemical composition. Among antioxidant property parameter, ascorbic acid content ranged between 12.62 to 76.15 mg 100 g-1 of Fresh Weight (FW), whereas, the total phenolic content and total antioxidant capacity varied from 41.10 to 139.59 mg GAE 100 g-1 of FW and 1.16 to 4.52 µmol Trolex Equivalent (TE) g-1 of FW, respectively. Among carotenoid parameters, lycopene and total carotenoids content in whole tomato fruit ranged between 0.47 to 5.48 and 1.14 to 5.79 mg 100 g-1 of FW, respectively. Interestingly, it was found that, among the evaluated genotypes, Exotic Collection (EC lines) showed significant enriched amount of these phytochemicals. Results

In this study, fifteen commercial varieties, nine exotic genotypes, and three wild species of tomato grown in Eastern India were analyzed for variations in different phytochemicals viz. ascorbic acid, lycopene, total carotenoids, total phenolics content and total antioxidant capacity. Selected genotypes showed significant differences with respect to phytochemical composition. Among antioxidant property parameter, ascorbic acid content ranged between 12.62 to 76.15 mg 100 g-1 of Fresh Weight (FW), whereas, the total phenolic content and total antioxidant capacity varied from 41.10 to 139.59 mg GAE 100 g-1 of FW and 1.16 to 4.52 µmol Trolex Equivalent (TE) g-1 of FW, respectively. Among carotenoid parameters, lycopene and total carotenoids content in whole tomato fruit ranged between 0.47 to 5.48 and 1.14 to 5.79 mg 100 g-1 of FW, respectively. Interestingly, it was found that, among the evaluated genotypes, Exotic Collection (EC lines) showed significant enriched amount of these phytochemicals. Results

BACKGROUND: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. OBJECTIVE: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. DESIGN: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for α-carotene, β-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, retinol, α-tocopherol, γ-tocopherol, and vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking

List of Fruits and Fruits Vitamin C content 100g of Apple Fruit contain Calcium - 6 mg Vitamin C - 4.6 mg 100g of Apricot Fruit contain Calcium - 13 mg

If theres one vitamin most people think they understand, it is vitamin C. This vitamin - also known as ascorbic acid - is present in many fruits and vegetables, and well known for its antioxidant properties and immune-enhancing powers. It is also responsible for aiding in the formation of connective tissue such as the skin, bones, and blood vessels. It also happens to be an essential component of health that the body is incapable of manufacturing on its own. As a result, it is critical that the human diet contain adequate sources of this nutrient.. As part of its grand mission in the body, this vitamin regenerates tissue, protects against many ailments like the cold and heart disease, helps to avoid scurvy, reduce bad cholesterol, and combat free radicals that can damage cellular integrity. It also aids in the bodys ability to absorb iron, and can delay the onset of cataracts.. Its effects on fatigue are well-documented. Though it can take several weeks of lowered vitamin C levels to produce ...

Objectives: To investigate the association between occupational social class and cardiovascular disease (CVD) incidence, and the extent to which classical and lifestyle risk factors explain such relationships, and if any differences persist after 65 years of age. Design, Setting and Participants: Prospective population study of 22,478 men and women aged 39-79 years living in the general community in Norfolk, United Kingdom, recruited using general practice age-sex registers in 1993-1997 and followed up for total mortality to 2006. Main results: In both men and women an inverse relationship was observed between social class and CVD incidence, with a relative risk of social class V compared to I of 1.90 in men (95% CI 1.47 to 2.47, P | 0.001) and 1.90 in women (95% CI 1.45 to 2.49, P | 0.001). Adjusting for classical and lifestyle risk factors (age, smoking, BMI, systolic blood pressure, total blood cholesterol, history of diabetes, physical activity, weekly alcohol intake and plasma vitamin C levels) had

Per 100 g, the leaf is reported to contain 73.1 g H2O, 8.4 g protein, 1.4 g fat, 11.8 g NFE, 2.2 g fiber, 3.1 g ash, 1,130 mg Ca, 80 mg P, 3.9 mg Fe, 9,000 IU vit. A, 0.21 mg thiamine, 0.09 mg riboflavin, 1.2 mg niacin, and 169 mg ascorbic acid. Leaves contain (ZMB) per 100 g, 321 calories, 36.3 g protein, 7.5 g fat, 47.1 g carbohydrate, 9.2 g fiber, 9.2 g ash, 1684 mg Ca, 258 mg P, 21 mg Na, 2,005 mg K, 25,679 mg b-carotene equivalent, 1.00 mg thiamine, 1.04 mg riboflavin, 9.17 mg niacin and 242 mg ascorbic acid. The flowers (ZMB) contain per 100 g, 345 calories, 14.5 g protein, 3.6 g fat, 77.3 g carbohydrate, 10.9 g fiber, 4.5 g ash, 145 mg Ca, 290 mg P, 5.4 mg Fe, 291 mg Na, 1,400 mg K, 636 mg b-carotene equivalent, 0.91 mg thiamine, 0.72 mg riboflavin, 14.54 mg niacin, and 473 mg ascorbic acid. Seeds (ZMB) contain 36.5% CP, 7.4% fat, 51.6% total carbohydrate, and 4.5% ash. The seed oil contains 12.3% palmitic, 5.2% stearic, 26.2% oleic, and 53.4% linoleic acids. The seed testa, which ...

Per 100 g, the leaf is reported to contain 73.1 g H2O, 8.4 g protein, 1.4 g fat, 11.8 g NFE, 2.2 g fiber, 3.1 g ash, 1,130 mg Ca, 80 mg P, 3.9 mg Fe, 9,000 IU vit. A, 0.21 mg thiamine, 0.09 mg riboflavin, 1.2 mg niacin, and 169 mg ascorbic acid. Leaves contain (ZMB) per 100 g, 321 calories, 36.3 g protein, 7.5 g fat, 47.1 g carbohydrate, 9.2 g fiber, 9.2 g ash, 1684 mg Ca, 258 mg P, 21 mg Na, 2,005 mg K, 25,679 mg b-carotene equivalent, 1.00 mg thiamine, 1.04 mg riboflavin, 9.17 mg niacin and 242 mg ascorbic acid. The flowers (ZMB) contain per 100 g, 345 calories, 14.5 g protein, 3.6 g fat, 77.3 g carbohydrate, 10.9 g fiber, 4.5 g ash, 145 mg Ca, 290 mg P, 5.4 mg Fe, 291 mg Na, 1,400 mg K, 636 mg b-carotene equivalent, 0.91 mg thiamine, 0.72 mg riboflavin, 14.54 mg niacin, and 473 mg ascorbic acid. Seeds (ZMB) contain 36.5% CP, 7.4% fat, 51.6% total carbohydrate, and 4.5% ash. The seed oil contains 12.3% palmitic, 5.2% stearic, 26.2% oleic, and 53.4% linoleic acids. The seed testa, which ...

Plasma vitamin C status plays a role in postherptetic neuralgia (PHN), and intravenous ascorbate helps relieve spontaneous pain in PHN

TY - JOUR. T1 - Effects of supra-nutritional levels of vitamin E and vitamin C on growth performance and blood parameters of Japanese quails. AU - Gallo, Antonio. AU - Prandini, Aldo. AU - Sigolo, Samantha. AU - Khazaei, Roshanak. AU - Seidavi, Alireza. AU - Ayasan, Tugay. PY - 2019. Y1 - 2019. N2 - A study was conducted to evaluate growth performance and blood serum parameters of Japanese quails fed diets containing different supra-nutritional levels of vitamin E and C (600, 800 and 1000 mg/kg). A completely randomised design was adopted and main effects (vitamin E and C) were arranged in a 3 × 3 factorial approach. Throughout the study (1-42 d), the supplementation with 1000 mg/kg vitamin E and C resulted in the highest feed intake, weight gain, and final body weight (p ,.01). Serum parameters showed that vitamin E and C at 1000 mg/kg determined the lowest serum concentrations of glucose, uric acid and creatinine (p ≤ 0.01) and the highest of high (HDL, p =.01) and low (LDL, p =.05) density ...

Vitamin C Soothing Lip Balm Vitamin C Skin Care Signature ingredient: Magnesium Ascorbal Phosphate is a form of vitamin C that is readily utilized by the skin cells to protect against damaging free radicals, and stimulate collagen and elastin production. One of the most stable forms of vitamin C, it will remain active over the shelf life of the product. Formulated with a powerful antioxidant team - Vitamins C & E - because antioxidants perform longer and more effectively when used in combination. Product description: Soothing Lip Balm provides effective free radical defense with Vitamins C and E plus nourishing, nutrient-rich, organic plant oils and waxes effectively protect against drying and chapping for soft, smooth lips. Features and benefits: Made with super antioxidants Vitamins C and E plus organic Coconut, Jojoba and Apricot kernel oils and nutrient-rich Aloe for soft, healthy lips. Who should use this product? For all skin types. Directions for use: Apply to lips as often

Detailed nutritional values of Candies, fruit snacks, with high in vitamin C content. Online analysis information with non-nutrients and nutrients composition facts table for item No. 19919 found in category Sweets. Data contents chart for nutritionists. Food details for CANDIES,FRUIT SNACKS,W/ HI VIT C in different kinds of quantities, amounts or measurements.

The report generally describes l-ascorbic acid 6-stearate, examines its uses, production methods, patents. L-Ascorbic Acid 6-Stearate market situation

Ingredients:. Vitamin C (Ascorbic Acid, Carrier: Glyceryl Tristearate), Bulking Agents: Microcrystalline Cellulose & Dibasic Calcium Phosphate, Magnesium Oxide, Vitamin E Natural Source (as D-Alpha Tocopheryl Acid Succinate) (from Soya), Lutein Esters & Zeaxanthin Esters (Carriers: Sugar, Natural Vitamin E, Ascorbyl Palmitate, Cellulose Gum), Zinc Sulphate, Tablet Coating (Hydroxypropylmethylcellulose, Hydroxypropylcellulose, Caprylic/Capric Triglyceride, Natural Source Colours [Titanium Dioxide, Iron Oxides]), Pantothenic Acid (as Calcium Salt), Citrus Bioflavonoids, Anti-Caking Agents: Stearic Acid, Magnesium Stearate & Silicon Dioxide, Thiamin (Vitamin B1 as Mononitrate), Niacin (Nicotinamide), Ferrous Fumarate, Natural Mixed Carotenoids (Betacarotene, Gamma-Carotene, Citroxanthin, Beta-Zeacarotene, Modified Starch, Antioxidants: DL-Alpha Tocopherol, Sodium Ascorbate, Corn Starch, Glucose Syrup), Vitamin B6 (Pyridoxine HCl), Bilberry Extract, Manganese Sulphate, Cross-linked Cellulose Gum, ...

It is very important to find the root of the problem first - most of the time, lack of Vitamin C causes bleeding gums - try vitamin C for a month at least, and see the results. Good dental care (brushing & flossing twice a day) a good, balanced diet, and lots of Vitamin C are a good way to maintain healthy teeth and gums. Vitamin C promotes healing, especially from bleeding gums.. Vitamins A and E, bioflavonoids, selenium, and zinc are key antioxidants for nutritional support for the gums. If gums are sore, tender, or bleeding: Take vitamin C supplements, such as vitafusion gummies, daily. You can also try an antiseptic rinse along with taking vitamin C. Coenzyme Q10 increases tissue oxygenation and has been shown to help decrease receding gum lines. It also works together with other vitamins and minerals to quicken your metabolism.. My boyfriend has terrible gum disease and this is what his dentists tell him: If it is not due to lack of dental hygiene or lack of regular cleanings, gingivitis ...

[132 Pages Report] Check for Discount on United States Erythorbic Acid Industry 2016 Market Research Report report by QYResearch Group. The United States Erythorbic Acid Industry 2016 Market Research Report...

Medscape - Bowel prep dosing for MoviPrep, PlenVu (polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Vitamin C helps neutralize free radicals to stop their damage and helps build connective tissues such as collagen [6]. Most other products contain ascorbic acid which is the USP synthesized so-called vitamin C. USP ascorbic acid is made by fermenting corn sugar into sorbitol, then hydrogenating it until it turns into sorbose, then acetone (commonly referred to as nail polish remover) is added to break the molecular bonds which creates ascorbic acid! All the vitamin C in Advanced Joint Complex is from Acerola (it is not a mixture of ascorbic acid with some Acerola thrown in as some do). Acerola is a cherry-like berry that is one of the most naturally concentrated vitamin C Foods known to exist--various cherries have been recommended to help people with arthritis [7]. Vitamin C in Foods such as Acerola exists in at least two forms unlike USP ascorbic acid which does not contain both forms [6]! Acerola is also less acidic than USP ascorbic acid (some feel that increased acidity tends to hurt, ...