TY - JOUR. T1 - Effect of dietary ascorbic acid supplementation level on productivity, mortality, and carcass characteristics of Venda chickens. AU - Malebane, Ingrid M.. AU - Ngambi, Jones Wilfred. AU - Norris, David. AU - Mbajiorgu, Christian. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Two experiments were carried out to determine the effect of dietary ascorbic acid supplementation levels on productivity, carcass characteristics, and mortality of indigenous Venda chickens. The first experiment determined the effect of dietary ascorbic acid supplementation levels on productivity and mortality rate of 175 unsexed Venda chickens between 1 and 6 weeks old. The second experiment determined the effect of dietary ascorbic acid supplementation levels on productivity, carcass characteristics, and mortality rate of 140 female Venda chickens between 8 and 13 weeks old. A completely randomized design was used in both experiments. Supplementation of grower diets with ascorbic acid ranged from 0 to 2,000 mg per ...
To the best of our knowledge, this is the first prospective cohort study to examine the relationship between serum vitamin C concentration and the incidence of stroke. Compared with previous cohort studies based on mortality data,6 10 our study based on incidence data may have some advantages, such as the relatively accurate diagnosis of disease outcomes and the inclusion of nonfatal cases. Serum vitamin C concentration was inversely associated with the subsequent incidence of all stroke during the 20-year observation period. Although a previous study that examined the association between plasma vitamin C concentration and stroke mortality6 had a potential weakness that arose from generally known inaccuracies in death certification, particularly in elderly people,6 our similar results based on incidence data would support their findings and emphasize the importance of the serum (or plasma) vitamin C concentration in predicting the occurrence of stroke.. Most interestingly, an inverse association ...
BACKGROUND: Some studies have hypothesized the protective role of Vitamin C against cardiovascular disorders (CVD) in patients with end-stage renal disease (ESRD). This study was designed to assess plasma Vitamin C concentration and its relationship to hemodialysis (HD) patients morbidity and mortality. METHODS: Plasma Vitamin C concentrations were assessed in HD patients using spectrophotometry and subjects were prospectively followed for up eighteen months for all-cause mortality. Any association between Vitamin C concentration and patients demographic data, co-morbidities, or the cause of ESRD were investigated using the Chi-square test. RESULTS: Ninety-one patients with a mean age of 56.7 ? 15.7 years were included in this study. The most frequent cause of ESRD was simultaneous hypertension and diabetes in 30 % of patients, followed by hypertension in 25.6 %, and diabetes in 11.1 %, respectively. About 34 % of patients had CVD as the most prevalent co-morbidity. Forty-nine patients (53.8 ...
Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin
Background: Reactive Oxygen species induced bronchial abnormalities may have important consequences in asthma, the main symptom being wheezing specially in children. Vitamin C is an important antioxidant known to quench the reactive oxygen species. A beneficial effect of fresh fruit consumption on lung function has been observed in several studies. Plasma levels Vitamin C was determined in relation to wheezing symptoms in cross sectional study. Methods: In a cross sectional blood samples of 50 patients attending pediatrics OPD, having wheezing and shortness of breath were analyzed for plasma Ascorbic acid level and compared with healthy controls of same age and sex. Results: The total number of 50 wheezing children were in the age group of 2 to 12 years with similar age matched controls. It was observed that the plasma ascorbic acid concentration in the wheezing children (0.43 - 0.12 mg/dl) was significantly decreased as compared to the normal controls ( 0.75 - 0.18 mg/dl ) P, 0.001. The highly ...
TY - JOUR. T1 - Effect of ascorbic acid administration in hemodialysis patients on in vitro oxidative stress parameters. T2 - Influence of serum ferritin levels. AU - Chen, Wei Teing. AU - Lin, Yuh Feng. AU - Yu, Fu Chiu. AU - Kao, Woei Yau. AU - Huang, Wen Hsin. AU - Yan, Horng Chin. PY - 2003/7/1. Y1 - 2003/7/1. N2 - Background: Ascorbic acid supplementation has been recommended to circumvent resistance to erythropoietin, which sometimes occurs in iron-overloaded uremic patients. In considering the pro-oxidant effect of ascorbic acid, the authors hypothesize that adjuvant therapy with larger doses of ascorbic acid in hemodialysis patients with iron overload may raise the risk of increasing free radical generation. The oxidative stress of intravenous ascorbic acid supplementation in hemodialysis patients was evaluated in this study. Methods: Six healthy subjects and 29 hemodialysis patients were enrolled. Chemical scavenging activity of various compounds was measured by in vitro ...
article{141703, author = {Langlois, Michel and Duprez, Daniel and Delanghe, Joris and De Buyzere, Marc and Clement, Denis}, issn = {0009-7322}, journal = {CIRCULATION}, language = {eng}, number = {14}, pages = {1863--1868}, title = {Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis (with comment: Vitamin C depletion linked to inflammation in peripheral artery disease. M. Larkin Lancet, 357, 2001, 1184).}, volume = {103}, year = {2001 ...
Researchers in China have begun clinical trials on the use of intravenous vitamin C as a remedy for the Wuhan coronavirus (CoVid-19). While government health authorities focus on pharmaceuticals and vaccines, Dr. Richard Cheng and his colleagues are investigating the simplicity with which injecting natural vitamin C can help to prevent the deadly outcomes increasingly […]
Mason, Shaun, Rasmussen, Bodil and Wadley, Glenn 2018, Ascorbic acid supplementation improves postprandial glucose and blood pressure in people with Type 2 diabetes, in 78th Scientific Sessions, American Diabetes Association, American Diabetes Association, [Orlando, Florida], doi: 10.2337/db18-789-P. ...
The aim of the present study was to investigate if the depletion of UV-B radiation affected the most representative carotenoids as well as the ascorbic acid content in tomato fruits, harvested at both breaker and firm red stages. To do this, three tomato genotypes, DRW 5981, HP 1, and Esperanza, were grown inside a greenhouse either covered with polyethylene transparent to UV-B or depleted of UV-B by a special covering film. The antioxidant properties of the fruits were evaluated on the water-insoluble fractions according to the ABTS method. UV-B effect on antioxidant activity was negligible in DRW and HP 1 genotypes, whereas it was detrimental in Esperanza at both ripening stages. This genotype seems to have a negligible capability of accumulating carotenoids and a great susceptibility to detrimental effects of UV-B; conversely, the DRW genotype shows high carotenoid levels under sunlight conditions and a further promotion by UV-B. On the other hand, the HP 1 mutant displays an intermediate ...
Intravenous vitamin C (ascorbic acid and L-ascorbic acid) therapy is the ideal Integrative, Complimentary, Non-toxic, Evidence-based therapy for multiple myeloma patients and survivors.
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Schedule Appointment. Intravenous Vitamin C Therapy with various other antioxidants and nutrients has been used for years as a treatment option for various types of cancer. The very high doses of Intravenous Vitamin C (15 to 100 grams/infusion) appear to be toxic (lethal) to cancer cells. It is used to stabilize membranes, boost the immune system, and increase energy. It also has anti-viral, anti-bacterial and anti-histamine properties. High doses of vitamin C given intravenously have very few side effects. Intravenous Vitamin C Therapy is not a cure for cancer but a viable treatment option.. Components of High Dose Intravenous Vitamin C & Mineral Infusions can include:. ...
Hypothesis 1A: Vitamin C infusion will significantly attenuate sepsis-induced systemic organ failure as measured by Sequential Organ Failure Assessment (SOFA) score,. Hypothesis 1B: Vitamin C infusion will attenuate sepsis-induced lung injury as assessed by the oxygenation index and the VE40. Hypothesis 1C: Vitamin C infusion will attenuate biomarkers of inflammation (C-Reactive Protein, Procalcitonin), vascular injury (Thrombomodulin, Angiopoietin-2), alveolar epithelial injury (Receptor for Advanced Glycation Products), while inducing the onset of a fibrinolytic state (Tissue Factor Pathway Inhibitor). ...
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Low maternal dietary vitamin E (but not vitamin C) intake during pregnancy has been associated with increased in vitro cord blood mononuclear cell (CBMC) proliferative responses, childhood wheezing and asthma. We investigated whether these associations reflect direct effects of vitamin E by investigating the effects of supplementing CBMC cultures with physiological concentrations of vitamin E. CBMC from seventy neonates were cultured supplemented with either nothing, α-tocopherol or ascorbic acid. Proliferative, IFN-γ, IL-4, IL-10 and TGF-β responses were measured. In general, vitamin E supplementation was associated with a trend for reduced proliferative responses after stimulation with antigens and house dust mite, and with increased proliferation after stimulation with timothy grass allergen. There was a trend for CBMC cultures to exhibit decreased secretion of IFN-γ, IL-10 and IL-4. Supplementation with vitamin C had no effect on CBMC proliferation, but increased IFN-γ and IL-4 production,
Background In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease. Methods and Results Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46±8 to 114±11 μmol/L, P=.001). In the prospectively defined group of patients with an abnormal baseline response (,5% dilation), ascorbic acid produced marked improvement in dilation (2.0±0.6% to 9.7±2.0%), whereas placebo had no effect (1.1±1.5% to 1.7±1.5%, P=.003 for ascorbic acid ...
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In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the potential use of intravenous vitamin C as a supportive factor in the treatment of cancer.
Why was I offered an infusion of vitamin C?. With my compromised immune system, I am susceptible to bacterial infections. As getting the best available treatment urgently has been drummed into me by my medical team, I do my best to avoid any kind of preventable illness. I had not heard of a vitamin C infusion as a first line of treatment, so asked for the evidence. I was told that the practice "uses vitamin C a lot, and has some really excellent results for all kinds of conditions". The GP, too, was also unable to offer a plausible biological explanation. The infusion was to be administered by the practice nurse and was to cost $130.. This is not the only medical practitioner offering vitamin C infusions and other unproven interventions. A growing number of medical clinics, claiming to be holistic, integrative, anti-ageing or health and wellness; centres, are offering a "comprehensive integrated approach to health and delaying aging based upon the biology of the neuroendocrine system, ...
Background: The use of high dose ascorbate infusions in cancer patients is widespread, but without evidence of efficacy. Several mechanisms whereby ascorbate could affect tumour progression have been proposed, including (i) the localised generation of cytotoxic quantities of H...
A group of medical doctors, healthcare providers and scientists met online March 17, 2020, to discuss the use of high dose intravenous vitamin C (IVC) in the treatment of moderate to severe cases of Covid-19 patients. The key guest was Dr. Enqian Mao, chief of emergency medicine department at Ruijin Hospital, a major hospital in…
The purposes of the present study are to determine the ascorbic acid values of foods served in the lunch room of North Texas State Teachers College Demonstration School at the time food preparation is completed, at the beginning of the serving period, and at the end of the serving period; to ascertain the loss of ascorbic acid during these intervals; and to determine the quantity of ascorbic acid present in the size portions served primary, elementary, and high school students.
ANTIOXIDANT ACTIVITY Shodhganga. The ascorbic acid and total phenolic content to antioxidant activity of fresh juices of four ripe and unripe citrus fruits namely Citrus limon, C. reticulata, C. sinensis and C. aurantium were, Journal of Fruit and Ornamental Plant Research Vol. 17/(2) 2009: 115-120 ANTIOXIDANT CAPACITY, ASCORBIC ACID AND PHENOLICS CONTENT IN WILD EDIBLE FRUITS. antioxidant activity, phenolic, flavonoid and ascorbic acid contents of commonly consumed vegetables in Nigeria and identify which of these vegetables has the highest The only indication of ascorbic acids autoxidative effect in humans has been observed following I.V. administration of massive amounts of ascorbic acid (80 g/2 days) in one individual with acute renal failure and a genetic disorder resulting in a deficiency of the enzyme glucose-6-phosphate dehydrogenase.34 All other in vivo studies support the antioxidant role of ascorbic acid.35-38 (i. The anti-oxidant activity and total phenolic content of alcoholic ...
Description: Ascorbyl Palmitate is a fat-soluble form of Vitamin C that can cross the blood-brain barrier and cell membranes. As a form of Vitamin C, it provides antioxidant activity and is intended to provide nutritive support for normal, healthy collagen synthesis, cartilage and bone development, immune function, capillary and blood vessel integrity and nerve impulse transmission. Size: 60ct 500mg Directions: Take 1 capsul daily. Serving Size: 1 Capsule 60 Servings per container Ingredients: Amount Per Serving - % Daily Value Vitamin C (as Ascorbyl Palmitate) 215 mg 358% Other Ingredients: Gelatin Capsule, Cellulose, Silica and Magnesium Stearate
Purpose: : To investigate the effect of ultraviolet radiation-B (UVR-B) exposure on lens ascorbate concentration in the pigmented guinea pig. Methods: : Twenty 20 pigmented guinea pigs were randomly divided into two groups. One group received drinking water supplemented with 0 mM ascorbate while the other group received drinking water supplemented with 5.5 mM ascorbate, for four weeks. All animals were thereafter unilaterally exposed to UVR-B. One day after the exposure to UVR, the animals were sacrificed and the lenses were removed for measurement of intensity of forward light scattering. Ascorbate concentration was measured once in each lens using ultrafiltration and HPLC with UVR detection. Results: : There was no significant difference of ascorbate content between exposed and not exposed lenses in either of the 0 mM or the 5.5 mM group [t-test]. Anterior subcapsular cataract developed in all exposed lenses and none of not UVR-exposed lenses. In both the ascorbate-supplemented and the not ...
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[150 Pages Report] Check for Discount on Global and Chinese Ascorbyl palmitate (CAS 137-66-6) Industry, 2016 Market Research Report report by Prof Research. The Global and Chinese Ascorbyl palmitate Industry, 2011-2021 Market...
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This cancer information summary provides an overview of the use of high-dose vitamin C (also known as ascorbate or L-ascorbic acid) as a treatment for people with cancer. This summary includes a brief history of early clinical trials of high-dose vitamin C; reviews of laboratory, animal, and human studies; and current...
The effect of acute endotoxin-induced septic shock on myocardium oxidative stress after low or high vitamin C and/or E dietary supplementation was studied in guinea pigs, laboratory animals which, like human, do not have capacity for ascorbate synthesis. Neither the antioxidant enzymes or GSH were modified by endotoxin and vitamin treatments. Vitamin E showed a strong capacity to protect the myocardium against both enzymatic and non-enzymatic lipid peroxidation even in the presence of endotoxin. Vitamin C supplementation increased heart ascorbate whereas endotoxic shock totally depleted the heart ascorbate of vitamin C supplemented animals without changing vitamin E. Endotoxin significantly increased myocardium uric acid, a marker of ischemia induced oxidative stress, in animals fed with low vitamin C levels. This increase was totally prevented in vitamin C supplemented, but not in vitamin E supplemented animals. Strongly depressed levels of plasma vitamin C have been recently described in ...
The effect of acute endotoxin-induced septic shock on myocardium oxidative stress after low or high vitamin C and/or E dietary supplementation was studied in guinea pigs, laboratory animals which, like human, do not have capacity for ascorbate synthesis. Neither the antioxidant enzymes or GSH were modified by endotoxin and vitamin treatments. Vitamin E showed a strong capacity to protect the myocardium against both enzymatic and non-enzymatic lipid peroxidation even in the presence of endotoxin. Vitamin C supplementation increased heart ascorbate whereas endotoxic shock totally depleted the heart ascorbate of vitamin C supplemented animals without changing vitamin E. Endotoxin significantly increased myocardium uric acid, a marker of ischemia induced oxidative stress, in animals fed with low vitamin C levels. This increase was totally prevented in vitamin C supplemented, but not in vitamin E supplemented animals. Strongly depressed levels of plasma vitamin C have been recently described in ...
The relatively common condition known as premature rupture of the chorioamniotic membranes (PROM) may result in premature delivery and infection. Earlier studies have found that vitamin C plays an important role in maintaining the collagen in the membrane throughout gestation but it is not stored well by the body, which excretes whatever it does not need on a daily basis.. The researchers, led by Esther Casanueva, set out to determine the effectiveness of a daily 100mg dose in preventing PROM.. In the controlled double-blind trial, 120 women in their 20th week of pregnancy were randomly assigned to two groups; one group received 100mg of vitamin C each day and the other received a placebo.. The womens plasma and leukocyte vitamin C concentrations were measured every fourth week and the results published in the April issue of the American Journal of Clinical Nutrition​ (81, 4: 859-863).. They showed that mean plasma vitamin C concentrations decreased as pregnancy progressed in all of the 109 ...
Fat-soluble vitamin C Ascorbyl palmitate is a highly bioavailable, fat-soluble derivative of ascorbic acid. It possesses all the benefits of vitamin C, but, unlike the water-soluble form, is able to be stored in the lipid cell membrane until the body is ready to put it to use. Vitamin C offers a wide range of support for the human body. It is a potent antioxidant and free radical scavenger. It supports the body by enhancing defense system cell activity. It is essential for the formation and maintenance of intercellular ground substance and collagen. Vitamin C aids in the absorption of iron and the formation of red blood cells and converts folic acid to active folinic acid. It maintains healthy histamine release and supports lymphocyte formation. Vitamin C is also required for the synthesis of carnitine and steroids. Vitamin C, one of the most potent dietary antioxidants, provides optimal nutritional support to all physiological functions, including, notably, vascular and capillary integrity in
An inflammatory component is present in the microenvironment of most neoplastic tissues. Inflammation and elevated C-reactive protein (CRP) are associated with poor prognosis and decreased survival in many types of cancer. Vitamin C has been suggested as having both a preventative and therapeutic role in a number of pathologies when administered at much higher-than-recommended dietary allowance levels. Since in vitro studies demonstrated inhibition of pro-inflammatory pathways by millimolar concentrations of vitamin C, we decided to analyze the effects of high dose IVC therapy in suppression of inflammation in cancer patients. 45 patients with prostate cancer, breast cancer, bladder cancer, pancreatic cancer, lung cancer, thyroid cancer, skin cancer and B-cell lymphoma were treated at the Riordan Clinic by high doses of vitamin C (7.5 g -50 g) after standard treatments by conventional methods. CRP and tumor markers were measured in serum or heparin-plasma as a routine analysis. In addition, serum
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AIMS Vitamin C (ascorbic acid) is thought to enhance immune function, but the mechanisms involved are obscure. We utilized an in vitro model of T-cell maturation to evaluate the role of ascorbic acid in lymphocyte development. RESULTS Ascorbic acid was essential for the developmental progression of mouse bone marrow-derived progenitor cells to functional T-lymphocytes in vitro and also played a role in vivo. Ascorbate-mediated enhancement of T-cell development was lymphoid cell-intrinsic and independent of T-cell receptor (TCR) rearrangement. Analysis of TCR rearrangements demonstrated that ascorbic acid enhanced the selection of functional TCRαβ after the stage of β-selection. Genes encoding the coreceptor CD8 as well as the kinase ZAP70 were upregulated by ascorbic acid. Pharmacologic inhibition of methylation marks on DNA and histones enhanced ascorbate-mediated differentiation, suggesting an epigenetic mechanism of Cd8 gene regulation via active demethylation by ascorbate-dependent Fe(2+) and 2
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Ascorbate and glutathione (GSH) are the primary water-soluble antioxidants in the CNS. Oxidative stress, sometimes indicated by loss of these antioxidants, has been linked to several clinical and experimental conditions, including cerebral ischemia. These conditions are also gender-linked, with greater incidence or severity in males than females. To test whether there are gender differences in oxidant/antioxidant regulation, we determined basal levels of ascorbate and GSH in rat brain and their loss after 1 h decapitation ischemia. We found that ascorbate levels in male rat brain were 7-10% higher than in females, depending on region, whereas GSH levels were gender-independent. Significant ascorbate loss (up to 12%) occurred in males during ischemia, with a regional pattern of cerebellum | hippocampus | prefrontal cortex. Loss of ascorbate in females was not significant in any region. By contrast, loss of GSH was significant in both males and females. Greater loss of GSH than ascorbate was in agreement
Per 100 g, the leaf is reported to contain 73.1 g H2O, 8.4 g protein, 1.4 g fat, 11.8 g NFE, 2.2 g fiber, 3.1 g ash, 1,130 mg Ca, 80 mg P, 3.9 mg Fe, 9,000 IU vit. A, 0.21 mg thiamine, 0.09 mg riboflavin, 1.2 mg niacin, and 169 mg ascorbic acid. Leaves contain (ZMB) per 100 g, 321 calories, 36.3 g protein, 7.5 g fat, 47.1 g carbohydrate, 9.2 g fiber, 9.2 g ash, 1684 mg Ca, 258 mg P, 21 mg Na, 2,005 mg K, 25,679 mg b-carotene equivalent, 1.00 mg thiamine, 1.04 mg riboflavin, 9.17 mg niacin and 242 mg ascorbic acid. The flowers (ZMB) contain per 100 g, 345 calories, 14.5 g protein, 3.6 g fat, 77.3 g carbohydrate, 10.9 g fiber, 4.5 g ash, 145 mg Ca, 290 mg P, 5.4 mg Fe, 291 mg Na, 1,400 mg K, 636 mg b-carotene equivalent, 0.91 mg thiamine, 0.72 mg riboflavin, 14.54 mg niacin, and 473 mg ascorbic acid. Seeds (ZMB) contain 36.5% CP, 7.4% fat, 51.6% total carbohydrate, and 4.5% ash. The seed oil contains 12.3% palmitic, 5.2% stearic, 26.2% oleic, and 53.4% linoleic acids. The seed testa, which ...
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Experiments were conducted to test the radioprotective effects of a naturally occurring reducing agent, ascorbic acid, on seeds (caryopses) of barley, Hordeum vulgare L. emend Lam. Seeds were soaked either before or after ..gamma.. or fission neutron irradiation in distilled water or ascorbic acid solutions ranging in concentration from 0.01 to 1.00 M. Results are reported as percentage germination, seedling height, seedling growth reduction, and (in one experiment) percent of cells with chromosome aberrations. As evidenced by both reduced germination and seedling growth, ascorbic acid was toxic when seeds were soaked for 1 hr at ambient temperature prior to irradiation and then planted immediately. When seeds were soaked in ascorbic acid before irradiation and soaked after irradiation in air-bubbled water at 0/sup 0/C for 18 hr, the toxicity disappeared, and a protective effect (which increased with increasing ascorbic acid concentration) was observed for ..gamma.. and, to a lesser extent, for neutron