Glycosaminoglycan/chitosan hydrogel for matrix-associated autologous chondrocyte implantation: An in vitro study<...
TY - JOUR. T1 - Glycosaminoglycan/chitosan hydrogel for matrix-associated autologous chondrocyte implantation. T2 - An in vitro study. AU - Fan, Fang Yu. AU - Chiu, Chien Chang. AU - Tseng, Ching Li. AU - Lee, Hsuan Shu. AU - Pan, Yung Ning. AU - Yang, Kai Chiang. PY - 2014. Y1 - 2014. N2 - Matrix-associated autologous chondrocyte implantation (MACI) is an effective treatment for full-thickness cartilage and osteochondral lesions with encouraging outcomes. However, problems include abnormal growth of chondrocytes during cultivation, cell dedifferentiation, and abnormally regenerated cartilage. A matrix that provides a physicochemical and biological microenvironment for restoring hypertrophic chondrocytes would be beneficial for MACI. Accordingly, this study evaluates the feasibility of using an injectable glycosaminoglycan (GAG)/chitosan hydrogel for MACI. Chitosan gel was prepared and GAGs (hyaluronan and chondroitin-6-sulfate) were added to fabricate a GAG/chitosan matrix. Porcine chondrocytes ...
Matrix assisted autologous chondrocyte transplantation for cartilage treatment: A systematic review<...
TY - JOUR. T1 - Matrix assisted autologous chondrocyte transplantation for cartilage treatment. T2 - A systematic review. AU - Kon, E.. AU - Filardo, G.. AU - Di Matteo, B.. AU - Perdisa, F.. AU - Marcacci, M.. PY - 2013/2/1. Y1 - 2013/2/1. N2 - Objectives: Matrix-assisted autologous chondrocyte transplantation (MACT) has been developed and applied in the clinical practice in the last decade to overcome most of the disadvantages of the first generation procedures. The purpose of this systematic review is to document and analyse the available literature on the results of MACT in the treatment of chondral and osteochondral lesions of the knee. Methods: All studies published in English addressing MACT procedures were identified, including those that fulfilled the following criteria: 1) level I-IV evidence, 2) measures of functional or clinical outcome, 3) outcome related to cartilage lesions of the knee cartilage. Results: The literature analysis showed a progressively increasing number of articles ...
Autologous Chondrocyte Transplantation Rehab
Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects - Full...
For the cartilage cell product NOVOCART® 3D plus, which is used in the study described here, the company TETEC AG obtained an expanded production authorization from the medication monitoring authorities in compliance with Section 13, Para. 1 of the Medicinal Products Act in 2003. This entitles TETEC AG to produce the pharmaceutical product and already distribute it. More than 6000 patients were already successfully treated with NOVOCART® 3D in Europe since 2003. In order to obtain a general market authorization for NOVOCART® 3D plus, this control group study is conducted, in which the superiority of the safety and effectiveness of carrier-bound Autologous Chondrocyte Transplantation with NOVOCART® 3D plus compared to the standard of care microfracture surgery needs to be proven. This study further aims at developing and validating known and new biologic markers for the quality and clinical efficacy of the product as requested in the context of identity, purity and potency characteristics of ...
Autologous Cartilage Chip Transplantation Improves Repair Tissue Composition Compared With Marrow Stimulation
Shoulder Debridement Waltham, MA | Microfracture Dedham, Boston, MA
Dr Suzanne Miller in Waltham, Dedham and Boston, MA offers shoulder debridement and microfracture. Microfracture is a technique used to repair damaged articular cartilage by making multiple small holes in the surface of the joint.
Bezmialem Science
The unique features of our method are as follows: 1) a SDHM with sufficient thickness for cartilage repair can be performed without a HA-based AM scaffold; and 2) increasing the number of SDHM applied to the defect area increases cartilage regeneration.. In recent years, several methods have been developed for repairing full-thickness cartilage defects. The MF technique performed arthroscopically as described by Steadman et al. (7) is a popular treatment method because it is easy applicable and cost-effective (23,24). Microfracture repairs the defective cartilage area by enabling the arrival of stromal cells. However, it results in shallow channels, wall compression, and increased trabecular thickness and density, as demonstrated by micro-computed tomography (microCT) and histology in several clinical and animal studies (25,26). Thus, it does not allow the regeneration of normal hyaline cartilage, perhaps because of the lack of sufficient MSCs or poor cellular differentiation (27-29). Compared ...
Cartilage failures. Systematic literature review, critical survey analysis, and definition<...
TY - JOUR. T1 - Cartilage failures. Systematic literature review, critical survey analysis, and definition. AU - Filardo, Giuseppe. AU - Andriolo, Luca. AU - Balboni, Federica. AU - Marcacci, Maurilio. AU - Kon, Elizaveta. PY - 2015/12/1. Y1 - 2015/12/1. N2 - Purpose: While midterm results of matrix-assisted autologous chondrocyte transplantation (MACT) are now available, less attention has been paid to the evaluation of failures of this surgical approach. Aim of this study was to analyse how failures are generally defined in cartilage surgery, in order to understand how the survival rate may change according to different definitions of failure. Methods: A systematic review on MACT in the knee was conducted to report failure rates as well as different failure definitions in the available literature. Afterwards, we analysed the survival curve at 8.5-year follow-up of a survey of 193 patients treated with MACT. Using different definitions to identify failures, we compared how the survival rate ...
TETEC - a B. Braun Company - Physicians - Clinical results
The first clinical experience with ACT (autologous chondrocyte transplantation) was reported on in 1994 by Brittberg et al. The primary success rate then stood at over 75% with clinically good and very good outcomes. The new formation of hyaline-like articular cartilage was histologically proven. These results were confirmed later by many other authors. The term hyaline-like was chosen because following the ACT a zonal structure formation, such as the one which exists in healthy hyaline cartilage had not yet been observed, although the biochemical constitution and the biomechanical weight bearing capacity of the newly formed cartilage basic structure corresponds closely to that of hyaline cartilage ...
Chondral Injury & Microfracture | Orthopaedic - Nick Carrington
Most acute chondral injuries will be treated with arthroscopic surgery as a day case procedure under general anaesthetic.. In general the only repairable injuries of this type are where there is quite a large chunk of articular cartilage with a sliver of bone (an osteochondral fracture) which can be pinned back in place.. If the fragment has to be removed and it leaves behind a crater in an important part of the knee with bare bone in the base, it will not heal up with normal joint surface cartilage. It may heal up with fibrocartilage or scar tissue in the base giving some sort of smooth covering. This type of covering can be encouraged by making some small holes in the bone. By encouraging bleeding into the area, scar tissue will form. This technique is sometimes referred to as microfracture.. If persistent problems arise because of a defect in the articular cartilage, then there are a number of specialised techniques which may be performed, but for which not everybody is ...
SUN: Chiney Ogwumike Has Microfracture Surgery
The reigning WNBA Rookie of the Year and top overall pick in the 2014 draft had a small lesion in her articular cartilage. Microfracture involves the setting of a cartilage matrix from a donor (i.e., a cadaver) into the lesion, to promote the growth of new cartilage that far more closely approximates the natural material (hyaline cartilage). A gluelike man-made protein is then applied to seal it ...
Palo Alto Cartilage Microfracture Surgery | Mountain View Joint Preservation Treatment
Microfracture surgery at Silicon Valley Orthopaedics, serving the Palo Alto area, can help repair damaged cartilage. Book an expert consultation with Dr. Nic Gay or Dr. Masi Reynolds today.
Foot & Ankle Problems: Fall 2 weeks after talus microfracture
I'm concerned that I have caused some damage due to a fall after my ankle surgery. It has been 2 weeks and I just got a hard cast today. I slipped going down the stairs and landed hard on my heel. There is a bit of pain, but I'm worried that I've messed up the microfracture. Any thoughts would be
2017 ISAKOS Congress Abstract Prospective Clinical Outcomes Following Microfracture Surgery for Isolated and Multi-Site Defects...
Following microfracture all patients demonstrated significant and clinically meaningful improvements in outcomes at a mean of 5.7 years, increasing age and BMI are the patient-related factors that may predict a poor outcome.
Is Microfracture Surgery Right For Your Knee?
Orange County orthopedic surgeon Dr. Ralph Venuto discusses when microfracture surgery is an appropriate option for patients with knee injuries.
Video Gallery : Techniques in Foot & Ankle Surgery
The video demonstrates the surgical technique for the arthroscopic treatment of an osteochondral lesion of the talus with micronized allograft cartilage matrix (BioCartilage). The lesion is debrided to its base and vertical borders are created. Marrow stimulation is then performed. Next all water is removed from the joint and the lesion is completely dried. The BioCartilage is introduced into the lesion and filled to just under the articular surface. It is contoured appropriately, and fibrin glue is applied to the surface of the lesion. This is allowed to set without manipulation for 5 minutes. ...
MACI, US | epgonline.org
Autologous cultured chondrocytes, MACI is an autologous cellularized scaffold product indicated for the repair of symptomatic, single or multiple full-thickness cartilage defects of the knee with or without bone involvement in adults.
Roentgen Ray Reader: October 2012
Red marrow is present in the fetal skeleton and converts to yellow marrow after birth. In sickle cell anemia (SCA) destruction of RBCs causes anemia which prevents the conversion of red marrow to yellow marrow. The persistent red marrow is seen in all bones of patients with SCA and has pathologic and radiologic consequences. Red marrow stimulation leads to widening of the medullary spaces and cortical thinning which can cause pathologic fractures. Coarse trabeculation and osteopenia may also be seen. Persistent red marrow presents as low signal intensity in osseous structures on T1WI. On skull radiographs the widening of the diploic spaces is a manifestation of bone marrow expansion. The hair on end appearance of the skull is secondary to coarse trabeculation from new bone formation. In the spine, cortical thinning results in biconcave deformities of the vertebral bodies sometimes referred to as the fish-mouth appearance. ...
ISAKOS: 2015 Congress in Lyon, France : Abstract View
Intra-articular fracture of the tibial plateau has a risk factor for post traumatic osteoarthritis.Large focal lesions of the tibial plateau resulting from fracture offer fewer management alternatives when compared with their femoral condylar counterparts. Techniques such as mosaicplasty or autologous chondrocyte transplantation have not been as positive for patients with tibial ...
Sara Fermanian | FrogHeart
Tissue engineering researchers, including Elisseeff, theorized that the specialized stem cells needed a nourishing scaffold on which to grow, but demonstrating the clinical value of hydrogels has taken a lot of time, Elisseeff says. By experimenting with various materials, her group eventually developed a promising hydrogel, and then an adhesive that could bind it to the bone.. After testing the combination for several years in the lab and in goats, with promising results, she says, the group and their surgeon collaborators conducted their first clinical study, in which 15 patients with holes in the cartilage of their knees received a hydrogel and adhesive implant along with microfracture. For comparative purposes, another three patients were treated with microfracture alone. After six months, the researchers reported that the implants had caused no major problems, and MRIs showed that patients with implants had new cartilage filling an average 86 percent of the defect in their knees, while ...
20 Second Timeout: Portlands Worst Fears Confirmed: Greg Oden Has Microfracture Surgery
Still, there is no getting around that this is a devastating blow to Oden and Portland and that Oden has a lot of rehabilitation work ahead of him before he can be a productive NBA player. If Oden is not able to play this season then he will become just the second number one overall pick since 1966 to not play in the NBA in the year that he was selected; in 1987, David Robinson did not join the San Antonio Spurs because he had to fulfill his commitment to the Navy. However, there have been several number one overall picks whose rookie seasons were impacted in some way by injuries, including future All-Stars Bob Lanier, Doug Collins and Bill Walton. Lanier actually did not miss a game during his first season but he was playing hurt and he told me, In hindsight, what we should have done--if I had had any sense and if there was some sophistication with the powers that be way back then in Detroit--is have me sit out the first half of the season, at least, and just worked on getting my knee right, ...
Microfracture
Described by Dr. Stone as a gift to his patients, this short, weekly blog focuses on sports, performance, & orthopaedic care.. ...
EPAs Utility MACT - More Policy-Driven Science - Reason Foundation
Today at 2pm, EPA Administrator Lisa Jackson will visit a childrens hospital in Washington, D.C. and unveil the Agencys new Utility MACT rules. She will
Mfx max str + JW + green mag + beta alanine bulking log - AnabolicMinds.com
im starting this as part of my break from hormones hoping to bulk up 10 lbs in 12 weeks. goin like this. 1-4 mass FX 4 caps ED, 5-8 6 caps ED 1-4 Jw 3
Bone Marrow Stimulation with G-CSF
Bone marrow stimulation with G-CSF (Neupogen®, Granocyte®) is only recommended for febrile neutropenia which does not respond to antibiotic treatment, severe neutropenia (granulocytes , 0.5 x 109 /L for more than 1 week), and in cases where it is necessary to administer curative treatment with sufficient dosage intensity.. ...
Bone Marrow Stimulation with G-CSF
Bone marrow stimulation with G-CSF (Neupogen®, Granocyte®) is only recommended for febrile neutropenia which does not respond to antibiotic treatment, severe neutropenia (granulocytes , 0.5 x 109 /L for more than 1 week), and in cases where it is necessary to administer curative treatment with sufficient dosage intensity.. ...
Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous...
In order to be able to use second-generation ACT techniques for the repair of cartilage defects in patients with OA, it is highly important to investigate whether OA chondrocytes have an irreversibly altered phenotype or if these cells can differentiate towards a hyaline cartilage phenotype after in vitro expansion. Today, there are conflicting data whether OA chondrocytes fulfill the prerequisites for ACT treatment or not [12, 13, 15, 21]. This encouraged us to investigate more thoroughly the chondrogenic differentiation potential of human OA chondrocytes using microarray technology in order to determine whether OA chondrocytes might possibly be used in second-generation ACT.. Microarray analysis of human OA and ND chondrocytes cultured in ML indicated that the OA chondrocytes were in a less differentiated state compared with the ND chondrocytes. This is thus in accordance with the differences detected in vivo between OA and ND cartilage [10, 22]. Re-differentiation in scaffold cultures ...
Results at 10 to 14 Years After Microfracture in the Knee - Full Text View - ClinicalTrials.gov
Articular cartilage lesions are commonly occurring. In a prospective study of 1,000 knee arthroscopies focal chondral or osteochondral defects were found in 19% of the patients (Hjelle 2002). Chronic articular cartilage defects do not heal spontaneously. However, acute traumatic osteochondral lesions or surgically inflicted lesions extending into subchondral bone, e.g. by drilling (Pridie 1959), spongialization, abrasion or microfracture with an angled awl (Rodrigo 1994) causing the release of pluripotent mesenchymal stem cells from the bone marrow, may heal with repair tissue consisting of fibrous tissue, fibrocartilage or hyaline-like cartilage. The microfracture technique causes little damage to the subchondral bone plate and the risk of heat necroses caused by drilling or abrasion is eliminated. The quality of the repair tissue after these bone marrow stimulating techniques depends on various factors including the species and age of the individual, the size and localization of the defect, ...
Cell therapy, biomaterials and other options may enhance cartilage repair<...
TY - JOUR. T1 - Cell therapy, biomaterials and other options may enhance cartilage repair. AU - Saris, Daniël B.F.. PY - 2013/3/1. Y1 - 2013/3/1. N2 - There are several articular cartilage repair techniques being used, including microfracture, autologous chondrocyte implantation and mosaicplasty, and orthopaedic surgeons have found they offer some improvement for patients, overall. The physicians who spoke with Orthopaedics Today Europe discussed indications for the major techniques currently used worldwide and noted that results of each approach are somewhat mixed. From their comments it seems that orthopaedic clinicians and researchers are divided over which cartilage repair approaches are optimal and whether developments being worked on now will deliver on the promise of improved outcomes in the future.. AB - There are several articular cartilage repair techniques being used, including microfracture, autologous chondrocyte implantation and mosaicplasty, and orthopaedic surgeons have found ...
Dr Barrow - Microfracture Technique: Overview
Microfracture is a surgical technique that has been developed to treat chondral defects, which are damaged areas of articular cartilage of the knee. It is a common procedure used to treat patients with full thickness damage to the articular cartilage that goes all the way down to the bone.. This arthroscopic procedure was first introduced about 20 years ago as a treatment method that uses the bodys own healing abilities and provides an enriched environment for tissue regeneration on the chondral surface.. Since its development, the microfracture procedure has been used by its originator to treat more than 2000 patients. Of these patients, 75 to 80% experienced significant pain relief and improvement in the ability to perform daily activities and participate in sports. Fifteen percent noticed no change, and five percent continued to have joint deterioration. Next ...
Diagnosis & Treatment of Ankle Disorders | Patient Education
When different surgical approaches have similar outcomes, the decision over treatment choice is based on individual surgeon preferences, experience, and lesion location and amount of cartilage damage. The initial surgical treatment for most defects involves arthroscopy with debridement (removal of damaged tissue), andmicrofracture.. Regardless of the specific technique, improvement in pain is seen in 85% of people. If the initial microfracture or drilling procedure is not successful, repeat microfracture for continued pain can be effective.. Revision microfracture is used in patients with persistent pain who have imaging results that suggest healing was incomplete but who cannot have more invasive surgical procedures. Repeat microfracture or drilling is a reasonable, low complication procedure for such patients.. Although the goal of drilling and microfracture is to stimulate healing and restoration of hyaline cartilage, defects usually heal with fibrocartilage, which is less organised scar ...
Microfracture Knee Surgery India | Knee Cartilage Treatment New Delhi
Dr (Mr) Tim Spalding | KNEEguru
Mr Tim Spalding is a knee surgeon whose interests include arthroscopic anterior and posterior cruciate ligament reconstruction, meniscal reconstructive surgery, meniscal transplantation, surgery for patello-femoral problems, articular cartilage repair and autologous chondrocyte transplantation, through to osteotomy and joint replacement. For more information about Meniscal
San Jose Cartilage Microfracture Surgery | Fremont Joint Preservation Treatment
Cartilage Replacement Adelaide | Microfracture | Knee Surgeon Adelaide
Options for knee pain two years after microfracture surgery - Orthopedics & Sports Medicine - MedHelp
Microfracture Surgery Recovery - 18 Week Update - Steves Blog
Hi - its been a year since someone commented on this thread and I can only assume that everyone has healed up and all the pain and discomfort has become a distant memory. I hope so in any case.. Im now in week 10 post op and still limping along on one crutch. Every now and then I experience pain related to what feels like the bones rubbing against each other - I dont know how to describe it - its just not muscular pain and I am terrified that all this effort has been wasted and that the op didnt work. My microfracture was relatively small according to the surgeons assistant - essentially the size of a South African 20c piece (about 6mm diameter), so the success rate is fairly high. But with this amount of swelling and pain, it feels like hes just about done the whole kneecap!. Ive been on the CPM once a week since the op and yesterday in the pool did some rotation type movements - Ive been told not to go on the exercise bikes at the gym but Im dying to go back and start shedding some ...
Microfracture Surgery Recovery - 18 Week Update - Steves Blog
Hi - its been a year since someone commented on this thread and I can only assume that everyone has healed up and all the pain and discomfort has become a distant memory. I hope so in any case.. Im now in week 10 post op and still limping along on one crutch. Every now and then I experience pain related to what feels like the bones rubbing against each other - I dont know how to describe it - its just not muscular pain and I am terrified that all this effort has been wasted and that the op didnt work. My microfracture was relatively small according to the surgeons assistant - essentially the size of a South African 20c piece (about 6mm diameter), so the success rate is fairly high. But with this amount of swelling and pain, it feels like hes just about done the whole kneecap!. Ive been on the CPM once a week since the op and yesterday in the pool did some rotation type movements - Ive been told not to go on the exercise bikes at the gym but Im dying to go back and start shedding some ...
Bioreactors for Tissue Engineering of Cartilage
The cartilage regenerative medicine field has evolved during the last decades. The first-generation technology, autologous chondrocyte transplantation (ACT) involved the transplantation of in vitro expanded chondrocytes to cartilage defects. The second generation involves the seeding of chondrocytes in a three-dimensional scaffold. The technique has several potential advantages such as the ability of arthroscopic implantation, in vitro pre-differentiation of cells and implant stability among others (Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L, N Engl J Med 331(14):889-895, 1994; Henderson I, Francisco R, Oakes B, Cameron J, Knee 12(3):209-216, 2005; Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A, Clin Orthop (374):212-234, 2000; Nagel-Heyer S, Goepfert C, Feyerabend F, Petersen JP, Adamietz P, Meenen NM, et al. Bioprocess Biosyst Eng 27(4):273-280, 2005; Portner R, Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM, J Biosci Bioeng 100(3):235-245, 2005;
How I Treat: Elbow Osteoarthritis - WSAVA2013 - VIN
Management of articular cartilage lesions is based on the concept that providing blood with mesenchymal stem cell precursors access to the lesion encourages healing by formation of fibrocartilage. Several marrow stimulating techniques have been described to achieve this. Abrasion arthroplasty involves uniform removal of subchondral bone until bleeding is achieved. This can be accomplished in the canine elbow by use of either a curette or burr attachment on a small joint shaver. The shaver is usually more rapid and efficient and generally just as accurate. Another marrow stimulating technique is microfracture. In this technique numerous microcracks are created in the subchondral bone plate with a specialized micropick to allow bleeding at the lesion surface.. Arthroplasty and Microfracture. Indications for abrasion arthroplasty or microfracture vary with the size and degree of cartilage loss. In general, lesions small to moderate size (1-2 cm in humans) can be treated with resurfacing techniques. ...
Microfracture technique versus osteochondral autologous transplantation mosaicplasty in patients with articular chondral...
More research needed issue 19 - oct 12
The Cochrane Library and other sources regularly publish new reviews, some of which highlight the Microfracture as the Primary Treatment for lack of good quality studies on which to base Osteochondral Lesions of the Talar Dome. recommendations. This is a good starting point for identifying a new area of research. The second step is Many techniques exist for the treatment of to find out what else has been published. If you OCLs of the talar dome. Good to excellent re- would like a literature search on any of these topics sults can be consistently reached in greater please contact the Library Service on ext 3831. than 80% of patients with arthroscopic de-bridement and microfracture. However, addi-tional prospective trials should be undertaken A systematic evaluation of content, struc- to determine differences in outcome between ture, and efficacy of interventions to im- techniques, size and location of the OCL, and prove patients self-management of cancer other patient quality factors, such as ...
Alternatives to knee microfracture surgery and cartilage implant surgery - Caring Medical Florida
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Microfracture and Lateral release Can this happen from 1 incident? - Orthopedics - MedHelp
I was injured on the job transferring a pt that twisted and started to fall. I twisted my knee and I heard a pop. Through months of physical therapy and not getting any better and MRI showed just that ...
Arthrex Arthrex PowerPick (February, 2014)
with the PowerPick from Arthrex. Its Ø1.5 mm x 4 mm depth needle removes bone instead of compacting it as is the case with typical microfracture pic
Arthrex Arthrex PowerPick (October, 2014)
with the PowerPick from Arthrex. Its Ø1.5 mm x 4 mm depth needle removes bone instead of compacting it as is the case with typical microfracture pic
Research Study For Those With Articular Cartilage Defects In the Knee | UVA Health
The University of Virginia, Department of Orthopaedic Surgery, is seeking adults with articular cartilage defects in the knee. The purpose of this study is to show if using an investigational tissue graft is better than the standard method of microfracture for the treatment of articular cartilage defects. This study will also document changes in knee pain and function after either surgery is performed.. The standard of care for treating articular cartilage defects in the knee is microfracture. This study is being done to observe if a graft is an efficient and more superior treatment option. For eligible participants, the defect will be treated with either microfracture or by using an investigational tissue graft.. This study involves 12 follow up visits over a 5 year period following surgery.. Study related clinic visits, research x-rays and MRI scans are provided free of charge. The study will also cover the costs of physical therapy that are not covered by your insurance up to $4,000 ...
Microfracture Surgery Louisville | Articular Cartilage Repair Kentucky
A Comparison of Abrasion Arthroplasty and Subchondral Microfracture in the Treatment of Chondral and Osteochondral Cartilage...
Introduction. The purpose of this study was to observe the difference in healing of chondral and osteochondral defects treated with abrasion arthroplasty versus subchondral microfracture.. Material and methods. 8 rabbits were divided in two groups (4 rabbits in group A and 4 rabbits in group B). In both groups, a 3.0 mm diameter defect was created on medial and lateral femoral condyles. In group A cartilage was shaved without penetrating the subchondral plate. In group B, defects were created into subchondral bone (3.0 mm deep). In each medial epicondyle defects, two 1.0 mm holes were performed into subchondral bone with orthopedic awl until bleeding was observed. Each lateral epicondyle defects underwent a abrasion arthroplasty until punctate bleeding was observed. Joint resurfacing and degenerative changes were evaluated grossly and histologically after 8 and 12 weeks.. Results. On gross observation a greater volume of repair tissue filled treated defects. Degenerative changes in the cartilage ...
Bone Marrow Concentrate Improves Early Cartilage Phase Maturation of a Scaffold Plug in the Knee: A Comparative Magnetic...
BACKGROUND Limited information exists on the clinical use of a synthetic osteochondral scaffold plug for cartilage restoration in the knee. PURPOSE/HYPOTHESIS The purpose of this study was to compare the early magnetic resonance imaging (MRI) appearance, including quantitative T2 values, between cartilage defects treated with a scaffold versus a scaffold with platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMAC). The hypothesis was that the addition of PRP or BMAC would result in an improved cartilage appearance. STUDY DESIGN Cohort study; Level of evidence, 3. METHODS Forty-six patients with full-thickness cartilage defects of the femur were surgically treated with a control scaffold (n = 11), scaffold with PRP (n = 23), or scaffold with BMAC (n = 12) and were followed prospectively. Patients underwent MRI with a qualitative assessment and quantitative T2 mapping at 12 months after surgery. An image assessment was performed retrospectively by a blinded musculoskeletal ...
Cartilage | OrthoVetSuperSite
We evaluated the effect of platelet-rich plasma-incorporated gelatin hydrogel microsphere (PRP/GM) together with subchondral drilling for cartilage regeneration in horses. Cartilage defects (diameter, 4.5 mm; depth, 3.0 mm) were created in both third carpal bones of six Thoroughbred horses. A subchondral hole was drilled at the center of this cartilage defect (diameter, 2.0 mm; depth, 35 mm) in one randomly selected carpal joint (test joint), whereas no subchondral hole was made in the contralateral joint (control joint). ...
Cartilage | OrthoVetSuperSite
We evaluated the effect of platelet-rich plasma-incorporated gelatin hydrogel microsphere (PRP/GM) together with subchondral drilling for cartilage regeneration in horses. Cartilage defects (diameter, 4.5 mm; depth, 3.0 mm) were created in both third carpal bones of six Thoroughbred horses. A subchondral hole was drilled at the center of this cartilage defect (diameter, 2.0 mm; depth, 35 mm) in one randomly selected carpal joint (test joint), whereas no subchondral hole was made in the contralateral joint (control joint). ...
Rebound Cartilage
KAKEN - Researchers | MINODA MINODA Yukihide (90453133)
Affiliation (Current):大阪市立大学,大学院医学研究科,講師, Research Field:Orthopaedic surgery,Basic Section 56020:Orthopedics-related, Keywords:半月板,再生医療,半月修復,修復,再生,エストロゲン,軟骨代謝,ノックアウトマウス,cre-loxPシステム,ATDC5, # of Research Projects:8, # of Research Products:101, Ongoing Project:Cartilage repair covered with autologous fibrin sheet on microfracture
Abiamiris season in jeopardy
Defensive end Victor Abiamiri had microfracture knee surgery and isnt expected to return to running until six months after surgery. The oft-injured Eagle underwent the operation on Feb. 9, according to Eagles trainer Rick Burkholder. - Jeff McLane, Philadelphia Inquirer
Sun's Chiney Ogwumike Has Surgery, Will Miss Part Of Season - Hartford Courant
Connecticut Sun forward Chiney Ogwumike underwent microfracture surgery Thursday on her right knee and will miss at least part of the WNBA season.
Efficiently Analyze the Cell Growth Characteristics of an Autologous Chondrocyte Culture
CKX-CCSW confluency checker software enables users to accurately estimate the proper timing for cell passage while minimizing human error.
Control Combinations or Idling Limit Alternatives for Solvent Cleaning Machines / MACT Information / Handouts / May 20, 2004...
The Toxics Use Reduction Institute helps Massachusetts companies and communities find innovative, cost effective ways to reduce toxic chemical use at the source, rather than treat wastes once produced.