TY - JOUR. T1 - Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. AU - Nakagawa, Yoshihito. AU - Akao, Yukihiro. AU - Morikawa, Hiroshi. AU - Hirata, Ichiro. AU - Katsu, Kenichi. AU - Naoe, Tomoki. AU - Ohishi, Nobuko. AU - Yagi, Kunio. N1 - Funding Information: The DLD-1 and COLO201 colon cancer cell lines used in this study were kindly supplied by the Health Science Research Resources Bank of the Japan Health Sciences Foundation. This work was supported in part by a Grant-in-Aid for Scientific Research by the Ministry of Education, Science, Sports and Culture of Japan.. PY - 2002/3/29. Y1 - 2002/3/29. N2 - Exposure of three colon cancer cell lines, SW480, DLD-1, and COLO201, to arsenic trioxide in the medium induced a marked concentration-dependent suppression of cell growth. The intracellular contents of reduced glutathione (GSH) in these cell lines tended to be inversely correlated with the sensitivity of the cells to arsenic trioxide. Among the ...

There are 15 Chapters to deeply display the Global Gallium Arsenide market.. Chapter 1, to describe Gallium Arsenide Introduction, product scope, market overview, market opportunities, market risk, market driving force;. Chapter 2, to analyze the top manufacturers of Gallium Arsenide, with sales, revenue, and price of Gallium Arsenide, in 2016 and 2018;. Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2016 and 2018;. Chapter 4, to show the Global market by regions, with sales, revenue and market share of Gallium Arsenide, for each region, from 2012 to 2018;. Chapter 5, 6, 7, 8 and 9, to analyze the key regions, with sales, revenue and market share by key countries in these regions;. Chapter 10 and 11, to show the market by type and application, with sales market share and growth rate by type, application, from 2012 to 2018;. Chapter 12, Gallium Arsenide market forecast, by regions, type and application, with sales and revenue, ...

TY - JOUR. T1 - Arsenic trioxide. T2 - Its use in the treatment of acute promyelocytic leukemia. AU - Sanz, Miguel A.. AU - Lo-Coco, Francesco. PY - 2006. Y1 - 2006. N2 - Acute promyelocytic leukemia (APL) represents approximately 10-15% of all adult cases of acute myeloid leukemia and is characterized by a unique genetic abnormality and frequent association with a severe hemorrhagic diathesis. An arsenic trioxide formulation for intravenous infusion has been developed and is currently licensed for the induction of remission and consolidation in adult patients with relapsed/refractory APL. Several studies have shown that arsenic trioxide is highly effective in the treatment of relapsed/refractory patients with APL, achieving remission rates of ,80%, high rates of molecular remission, and durable periods of disease-free survival. Furthermore, recent studies indicate that arsenic trioxide may also have a role in the treatment of newly diagnosed patients, either as a single agent or in combination ...

TRIVENI INTERCHEM PVT. LTD. - Exporter, Manufacturer, Distributor, Supplier, Trading Company of Arsenides Aluminium arsenide,Aluminium gallium arsenide,Aluminium indium arsenide,Arsenide,Boron arsenide,Cadmium arsenide,Gallium arsenide,Gallium arsenide phosphide,Gallium manganese arsenide, India

Cycle 1 cytarabine 10 mg/m^2 was administered subcutaneously (sc) twice daily (bid) on days 1-14. 0.25 mg/kg arsenic trioxide was administered intravenously (iv) on days 1-5 and days 8-12. Cycle 2 A second identical cycle of cytarabine and arsenic trioxide was given to patients with persistent disease. Patients who achieved complete remission (CR), complete remission with incomplete platelet count recovery (CRp), or partial remission (PR) after 1 or 2 cycles received a 14-day consolidation cycle of cytarabine and arsenic trioxide with the doses and schedule identical to the initial cycle. A recovery period of up to 4 weeks between the attainment of CR, CRp, or PR and the initiation of consolidation treatment was allowed. Patients who completed consolidation treatment started maintenance treatment of arsenic trioxide 0.25 mg/kg iv on days 1 and 4 and cytarabine 10 mg/m^2 sc bid on days 1 through 7 of a 28-day cycle ...

The purpose of this study is to determine whether NRX 195183 is effective in the treatment of relapsed or refractory Acute Promyelocytic Leukemia

The purpose of this study is to study the effect of an anticancer drug, Arsenic Trioxide, in patients with small cell lung cancer who have failed at least one standard chemotherapy regimen as well as patients who are unable to tolerate the standard treatment for their cancer. The investigators seek to establish the safety of and efficacy of Arsenic Trioxide in this patient group. The study will include up to 36 participants with small cell lung cancer.. The investigators want to find out what effects, good or bad, that the study drug has on your cancer. This study will also look at specific biomarkers in your blood and in the tumor tissue which may help the investigators to determine if the levels of these biomarkers are related to tumor response to treatment.. Arsenic Trioxide, also known by the brand name, Trisenox, is a chemotherapy drug approved by the Food and Drug Administration (FDA) for the treatment of a specific type of blood cancer called Acute Promyelocytic Leukemia. It works in part ...

Arsenic Trioxide - Get up-to-date information on Arsenic Trioxide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Arsenic Trioxide

Arsenic is a highly poisonous metallic element in the nitrogen family of group Va in the periodic table. Symbol As; aomic number 33; atomic mass 74.9216; melting point ca 817°C; sublimation point ca 613°C; specific gravity 6.80 or 7.004; 5.73; valence -3, 0, +3, or +5.; electronic config. [Ar]3d104s24p3. It appears in three allotropic forms, yellow, black, and gray. The stable form is a brittle, steel-gray hexagonal solid that oxidizes rapidly in air, and at high temperatures burns to form a white cloud of arsenic trioxide. Arsenic and some arsenic compounds sublime when heated and convert to gaseous form. Arsenic is an omnipresent element as arsenic minerals in the various lithosphere or fossil fuels including realgar, orpiment, and arsenopyrite. It is prepared commercially from arsenical pyrites (sulfide ores) by condensation of sublimed gas and by the reduction of white arsenic with carbon. This element contributes hardness and is used in preparing alloys for hard and corrosion-resistant ...

JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia

JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism. Benjamin D. Bowling, Nicole Doudican, Prashiela Manga, and Seth J. Orlow, Department of Dermatology, NYU School of Medicine, New York City, New York. (Sponsored by David J. Leffell, Department of Dermatology, Yale University School of Medicine). Current standard chemotherapeutic regimens for malignant melanoma are unsatisfactory. Although in vitro studies of arsenic trioxide (ATO) have demonstrated promise against melanoma, recent phase II clinical trials have failed to show any significant clinical benefit when used as a single agent. To enhance the efficacy of ATO in the treatment of melanoma, we sought to identify compounds that potentiate the cytotoxic effects of ATO in melanoma cells. Through a screen of 2000 marketed drugs and naturally occurring compounds, and subsequent mechanistic testing, a variety of antibiotic inhibitors of ...

Description of the drug arsenic trioxide Intravenous. - patient information, description, dosage and directions. What is arsenic trioxide Intravenous!

Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk Acute Promyelocytic Leukemia (APL)

Learn about Trisenox (Arsenic Trioxide Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.

Abstract: Background: Lung cancer is one of the most lethal and common cancers in the world, causing up to 3 million deaths annually. The chemotherapeutic drugs that have been used in treating lung cancer include cisplatinpemetrexed, cisplastin-gencitabinoe, carboplatin-pacitaxel and crizotinib. Arsenic trioxide (ATO) has been used in the treatment of acute promyelocytic leukemia. However, its effects on lung cancer are not known. We hypothesize that ATO may also have a bioactivity against lung cancer, and its mechanisms of action may involve apoptosis, DNA damage and changes in stress-related proteins in lung cancer cells. Methods: To test the above stated hypothesis, lung carcinoma (A549) cells were used as the test model. The effects of ATO were examined by performing 6-diamidine-2 phenylindole (DAPI) nuclear staining for morphological characterization of apoptosis, flow cytometry analysis for early apoptosis, and western blot analysis for stressrelated proteins (Hsp70 and cfos) and apoptotic ...

(2010) A., S.D.. Blood Reviews. Over the last 17years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As2O3 in front-line therapy is under investigation. Recent ...

PubMed journal article: Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Download Prime PubMed App to iPhone, iPad, or Android

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Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and caspase-independent cell death involving mitochondrial dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of GSH modulator, buthionine sulfoximine but not ascorbic acid. Gene expression analysis of arsenic-resistant OVCAR-3 (OVCAR-3/AsR) cells showed the involvement of multiple factors mediating its chemoresistance. Of particular interest, a genetic hub involving elevated interleukin 1A signalling was identified. This could consecutively modulate the ...

OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer cell line MCF-7/ADM. METHODS: Cytotoxicity of As(2)O(3) and the sensibility to adriamycin (ADM) in MCF-7/ADM cel

Figure 4: Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung Cancer

Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been Removed By Surgery This study is currently…

AMBICA PHARMA - Manufacturer,Supplier,Exporter of Arsenic Trioxide from India. We offer best quality of products at a best price rate.

This epidemiological study investigated the association between β-cell function (a predictive factor of diabetes development) and the organic arsenic arsenobetaine (an agent less toxic to humans). Urine arsenobetaine was revealed to be associated with HOMA-β in the normal population (without diabetes), especially in males, even after adjusting for factors affecting diabetes and β-cell function, while no association was shown with HOMA-IR which is associated with insulin resistance.. Despite several conflicting results, arsenic has been reported to be correlated with diabetes in many epidemiological studies [6, 9, 23-31], and arsenic can affect insulin resistance and β-cell function [7]. In some experimental studies, arsenite was found to induce oxidative stress in pancreatic β-cells and reduce insulin transcription and secretion [32, 33], caused by the altered expression of essential genes such as the Pdx1 gene [34, 35] and insulin gene [36] for pancreas development, insulin production, and ...

Adult patients who received the chemotherapy drug arsenic trioxide (Trisenox) immediately after standard chemotherapy had a significantly higher remission rate and better overall survival than those who received standard chemotherapy, according results of a phase III cancer clinical trial for an uncommon form of leukemia.. Seventy-seven percent of adult patients with acute promyelocytic leukemia who received arsenic trioxide remained alive and in remission, free of relapse, three years after diagnosis. This compared with 59 percent on the standard treatment. The greater effectiveness of the experimental combination also resulted in better overall survival of 86 percent after three years for the patients who received the arsenic trioxide compared to 77 percent for patients on the standard treatment arm.. Dr. Fred Appelbaum, director of the Centers Clinical Research Division, helped conceive, write the protocol, enroll patients and write up the results for the NCI-sponsored trial.. Acute ...

An ensemble Monte Carlosimulation is used to compare high field electron transport in bulk InAs, InP and GaAs. In particular, velocity overshoot and electron transit times are examined. For all materials, we find that electron velocity overshoot only occurs when the electric field is increased to a value above a certain critical field, unique to each material. This critical field is strongly dependent on the material, about 3 kV/cm for InAs, 10 kV/cm for InP and 5 kV/cm for the case of GaAs, We find that InAs exhibits the highest peak overshoot velocity and that this velocity overshoot lasts over the longest distances when compared with GaAs and InP. Finally, we estimate the minimum transit time across a 1 μm InAs sample to be about 2 ps. Similar calculations for InP and GaAs yield 6.6 and 5.4 ps, respectively. We find that the optimal cutoff frequency for an ideal InAs based device ranges from around 79 GHz when the device thickness is set to 1 μm. We thus suggest that indium arsenide offers great

Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, ...

TY - JOUR. T1 - Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial. AU - Elliott, Moira. AU - Ford, S J. AU - Prasad, E. AU - Dick, L J. AU - Farmer, H. AU - Hogg, P J. AU - Halbert, G W. N1 - Copyright © 2012 Elsevier B.V. All rights reserved.. PY - 2012/4/15. Y1 - 2012/4/15. N2 - The novel organoarsenical GSAO, 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid, has potential anti-angiogenic capability with application in cancer where tumour metastasis relies on neo-vascularisation. As GSAO arsenic is trivalent, the arsenoxide moiety reacts with appropriately spaced cysteine residues on adenine nucleotide translocase (ANT) mitochondrial membrane protein. Molecular oxidation of the arsenic to the pentavalent structure, as in the degradant GSAA (4-(N-(S-glutathionylacetyl)amino) phenylarsonic acid), prevents sulphydryl interaction and risks abolition of activity. We report here on formulation studies aiming to produce a parenteral ...

FROM JOURNAL OF CLINICAL ONCOLOGY. The combination of all-trans--retinoic acid (ATRA) and arsenic trioxide continues to show advantages over ATRA and chemotherapy as first-line therapy for patients with low- or intermediate-risk acute promyelocytic leukemia (APL), investigators report.. The final analysis of the APL046 study , a noninferiority trial of ATRA plus arsenic trioxide (ATRA-ATO) vs. ATRA and standard chemotherapy, showed that event-free survival (EFS) and overall survival (OS) were significantly better among patients assigned to ATRA-ATO. Patients in this group also had a significantly lower cumulative incidence of relapse, reported Francesco Lo-Coco, MD, of University Tor Vergata in Rome and colleagues.. Our results support the use of ATRA-ATO in patients with newly diagnosed APL and point to this strategy as the new standard of care for low- or intermediate-risk patients. Studies exploring the role of ATRA-ATO are warranted in other APL subsets including high-risk, pediatric, and ...

Background Lung tumor is among the most lethal and common malignancies in the world leading to up to 3 million fatalities annually. for morphological characterization of apoptosis movement cytometry evaluation for early apoptosis and traditional western blot evaluation for stress-related protein (Hsp70 and cfos) and apoptotic proteins expressions. Also the one cell gel electrophoresis (Comet) assay was utilized to judge the genotoxic impact. Outcomes ATO-induced apoptosis was evidenced by chromatin condensation and formation of apoptotic bodies as revealed by DAPI nuclear staining. Cell shrinkage and membrane blebbing were Neratinib observed at 4 and 6 μg/ml of ATO. Data from the western blot analysis revealed a significant dose-dependent increase (p < 0.05) in the Hsp 70 caspase 3 and p53 protein expression and a significant (p < 0.05) decrease in the cfos and bcl-2 protein expression at 4 and 6 μg/ml of ATO. There was a slight decrease in cytochrome c protein expression at 4 and 6 μg/ ml of ...

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NEW ORLEANS-Two forms of arsenic are effective for inducing remissions in people with acute promyelocytic leukemia (APL), according to data presented at the ASH meeting. 1

Hydrogen passivation of Si δ-doped GaAs grown by molecular beam epitaxy. Swaminathan, V.; Asom, M. T.; Livescu, G.; Geva, M.; Stevie, F. A.; Pearton, S. J.; Lopata, J. // Applied Physics Letters;12/31/1990, Vol. 57 Issue 27, p2928 Hydrogen passivation of Si δ-doped GaAs grown by molecular beam epitaxy is studied. Just as in uniformily Si-doped GaAs, exposure of the δ-doped material to a low frequency (30 kHz) hydrogen plasma at 250 °C for 30 min deactivates the Si donors in the δ spikes. For samples with Si... ...

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Learn about the veterinary topic of Inorganic Arsenicals (Toxicity). Find specific details on this topic and related topics from the Merck Vet Manual.

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Learn about the potential side effects of Trisenox (arsenic trioxide). Includes common and rare side effects information for consumers and healthcare professionals.

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial

Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.

Background The tumor associated antigen (TAA) gp100 was one of the first identified and has been used in clinical trials to treat melanoma patients. also collected as secondary endpoints. Patients that were HLA-A*2402 positive with stage IV melanoma were enrolled according to the criteria set by the protocol and immunized with a vaccine consisting of epitope peptide (VYFFLPDHL, gp100-in4) emulsified with incomplete Freunds adjuvant (IFA) for the total of 4 occasions with two week intervals. Prior to each vaccination, peripheral bloodstream mononuclear cells (PBMCs) had been separated in the blood and kept at -80C. The kept PBMCs had been thawed and analyzed for the regularity from the peptide particular T lymphocytes by IFN- ELISPOT and MHC-Dextramer assays. Outcomes No related undesirable events higher than quality I had been seen in the six sufferers signed up for this research. No clinical replies had been seen in the enrolled sufferers although vitiligo was noticed following the vaccination ...

https://doi.org/10.18632/oncotarget.5836 Wenchao Zhou, Lin Cheng, Yu Shi, Susan Q. Ke, Zhi Huang, Xiaoguang Fang, Cheng-wei Chu, Qi Xie, Xiu-wu Bian, Jeremy N. Rich, Shideng Bao

BACKGROUND: The studies have demonstrated that arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) takes effects in treatment of acute promyelocytic leukemia (APL) through different underlying mechanisms. This has established the molecular foundation of ATO plus ATRA therapy. Currently, ATO plus ATRA has also been widely used in clinical practice. OBJECTIVE: To assess the efficacy and safety of ATO in combination with ATRA for APL. SEARCH STRATEGY: The Cochrane Library (Issue 1, 2009), Cochrane Central Register of Controlled Trials (from 1970 to January 2009), MEDLINE (from 1978 to October 2008), EMBASE (from 1950 to March 2009), Chinese Biological Medical Literature Database (from 1978 to December 2008), CNKI (from 1994 to December 2008), China Medical Academic Conference Database (from 1994 to December 2008) were electronically searched ...

Find quality suppliers and manufacturers of 1309-64-4(Diantimony trioxide) for price inquiry. where to buy 1309-64-4(Diantimony trioxide).Also offer free database of 1309-64-4(Diantimony trioxide) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.

Despite the threat to human health and the environment, industrial poultry producers continue to use arsenical drugs to boost growth rates. A new study measured how much of this arsenic ends up in your meat.

A process for fabricating layered semiconductor structures, particularly thin gallium arsenide solar cells, on reusable substrates. The structure is fabricated by depositing a selectively removable layer such as gallium aluminum arsenide onto a substrate, and then depositing a solar cell basic structure on the selectively removable layer. Preferably, the solar cell basic structure includes a layer of p-type gallium arsenide on the layer of gallium aluminum arsenide, a layer of n-type gallium arsenide on the p-type gallium arsenide, and a transparent glass cover over the n-type gallium arsenide layer. The solar cell basic structure is separated from the substrate by selectively dissolving the gallium aluminum arsenide layer, and a new layer of gallium aluminum arsenide is epitaxially deposited upon the exposed face to form a thin, lightweight gallium arsenide solar cell. If the layer of p-type gallium arsenide is about 0.5 microns thick or less, the new layer of gallium aluminum arsenide may be omitted.

TY - JOUR. T1 - Size control of arsenic trioxide nanocrystals grown in nanowells. AU - You, Eun Ah. AU - Ahn, Richard W.. AU - Min, Hyung Lee. AU - Raja, Meera R.. AU - OHalloran, Thomas V.. AU - Odom, Teri W.. PY - 2009/8/12. Y1 - 2009/8/12. N2 - (Figure Presented) This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.. AB - (Figure Presented) This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration ...

Until recently, chicken producers would routinely supplement poultry feed with a growth-promoting arsenical drug called roxarsone, which also treats intestinal parasites in the birds and gives their meat an appealing pink color. A study in this issue of EHP shows that inorganic arsenic (iAs) accumulates in the breast meat of broiler chickens, potentially as a result of treatment with roxarsone. In 2011 the U.S. Food and Drug Administration (FDA) found that the livers of roxarsone-treated chickens had elevated levels of iAs, a known human carcinogen. In response, roxarsones manufacturer, Pfizer, voluntarily pulled the drug off the U.S. market, although it is still sold overseas, and a similar arsenical drug is still available in the United States. Sampling for the new study took place between December 2010 and June 2011, before Pfizer withdrew roxarsone from the U.S. market. Roxarsone is an organic form of arsenic, which although less toxic to humans than the inorganic species implicated in cancer, has

Inclusion Criteria: - Diagnosis Patients must have a clinical diagnosis of acute promyelocytic leukemia (APL) morphology or FAB M3 variant confirmed by RT-PCR assay for PML-RARα or chromosome analysis/FISH showing t(15:17) translocation. A patient may be entered prior to confirmatory studies, but a patient who is subsequently found to be PML-RARα negative will be removed from protocol treatment. - Prior Treatment The patient must not have received any systemic definitive treatment for APL, including cytotoxic chemotherapy, retinoids or arsenic trioxide. Prior therapy with corticosteroids, hydroxyurea or leukapheresis will not exclude the patient. - Age: Patients must be of age eighteen (18) or above. - Other Criteria - Patients must have the following laboratory values: - Bilirubin equal or less than 1.5 times the upper limit of normal. - Creatinine equal or less than 1.5 times the upper limit of normal - Pregnancy / Nursing Status - Patients entered into this study should be non-pregnant and ...

This phase III trial studies tretinoin and arsenic trioxide in treating patients with newly diagnosed acute promyelocytic leukemia. Standard treatment for

Page contains details about metal-contacted gallium arsenide/indium arsenide core/shell nanowire device . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

Arsenic toxicity is species-dependent for mammals and is transformed to other metabolites in various organs. In order to understand its metabolism, in-vitro simulation experiments were set up for various organ tissues. As(V) was transformed to As(III), while DMA(V) was changed to DMAS in sheep rumen, but the suspected MA-V) was not formed. This is different for the incubation of seaweed in rumen fluid, which points to a different unknown source for MA(V). In another study, dog MDCK kidney cells showed that inorganic arsenicals were methylated in kidney cells while the exposed DMAS was only oxidized to DMA(V) in kidney cells, and the exposed DMA(V) rarely transformed. The toxicities of arsenicals in dog kidney cells is dependant upon the uptake rates and the transformation of arsenicals. DMAS was as toxic as the inorganic arsenic species and an order to magnitude more toxic than the oxo-species. Methylated arsenic species can accumulate in hair and wool and can be used as a biomarker for arsenic ...

This phase III trial studies tretinoin and arsenic trioxide in treating patients with newly diagnosed acute promyelocytic leukemia. Standard treatment for acute promyelocytic leukemia involves high doses of a common class of chemotherapy drugs called anthracyclines, which are known to cause long-term side effects, especially to the heart. Tretinoin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Arsenic trioxide may stop the growth of cancer cells by either killing the cells, by stopping them from dividing, or by stopping them from spreading. Completely removing or reducing the amount of anthracycline chemotherapy and giving tretinoin together with arsenic trioxide may be an effective treatment for acute promyelocytic leukemia and may reduce some of the long-term side effects.. See detailed information including eligibility.. ...

Arsenic biochemistry refers to biochemical processes that can use arsenic or its compounds, such as arsenate. Arsenic is a moderately abundant element in Earths crust, and although many arsenic compounds are often considered highly toxic to most life, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms. This pattern is general for other related elements, including selenium, which can exhibit both beneficial and deleterious effects. Arsenic biochemistry has become topical since many toxic arsenic compounds are found in some aquifers, potentially affecting many millions of people via biochemical processes. The evidence that arsenic may be a beneficial nutrient at trace levels below the background to which living organisms are normally exposed has been reviewed. Some organoarsenic compounds found in nature are arsenobetaine and arsenocholine, both being found in many marine organisms. Some ...

Trisenox (arsenic trioxide) injection has been approved in combination with tretinoin for the treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (APL)

A Schottky-barrier gate gallium arsenide field effect structure is made using a self-aligned gate fabrication technique. The resulting device includes source and drain regions, which are parts of a conducting channel formed through ion implantation or epitaxial growth or a combination of the two. A gate is formed on the same channel by first etching a portion of the channel between the source and the drain regions to form a gate window which then receives a Schottky-barrier gate electrode.

Page contains details about strontium sulfide/indium gallium arsenide nanocrystals . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

Hundreds of millions of people world-wide are exposed to unacceptable levels of arsenic in drinking water. This is a public health crisis because arsenic is a Group I (proven) human carcinogen. Human cells methylate arsenic to monomethylarsonous acid (MMAIII), monomethylarsonic acid (MMAV), dimethylarsinous acid (DMAIII), and dimethylarsinic acid (DMAV). Although the liver is the predominant site for arsenic methylation, elimination occurs mostly in urine. The protein(s) responsible for transport of arsenic from the liver (into blood), ultimately for urinary elimination are unknown. Human multidrug resistance protein 1 (MRP1/ABCC1) and MRP2 (ABCC2), are established arsenic efflux pumps, but unlike the related MRP4 (ABCC4), are not present at the basolateral membrane of hepatocytes. MRP4 is also found at the apical membrane of renal proximal tubule cells making it an ideal candidate for urinary arsenic elimination. In the current study, human MRP4 expressed in HEK293 cells reduced the ...

2-Methoxyestradiol Induces Mitotic Arrest, Apoptosis, and Synergistic Cytotoxicity with Arsenic Trioxide in Human Urothelial Carcinoma Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Arsenic is one of the most ubiquitous toxins and endangers the health of tens of millions of humans worldwide. It is a mainly a water-borne contaminant. Inorganic trivalent arsenic (AsIII) is one of the major species that exists environmentally. The transport of AsIII has been studied in microbes, plants and mammals. Members of the aquaglyceroporin family have been shown to actively conduct AsIII and its organic metabolite, monomethylarsenite (MAsIII). However, the transport of AsIII and MAsIII in in any fish species has not been characterized. In this study, five members of the aquaglyceroporin family from zebrafish (Danio rerio) were cloned, and their ability to transport water, glycerol, and trivalent arsenicals (AsIII and MAsIII) and antimonite (SbIII) was investigated. Genes for at least seven aquaglyceroporins have been annotated in the zebrafish genome project. Here, five genes which are close homologues to human AQP3, AQP9 and AQP10 were cloned from a zebrafish cDNA preparation. These genes were

Arsenic(III), As, monomethylarsonic acid (MMAA), dimethylarsinic acid (DMAA) and arsenobetaine (AsB) were separated by high-performance liquid chromatography (HPLC) and determined on-line by inductively coupled plasma mass spectrometry (ICP-MS). Two forms of HPLC were used: ion pairing and ion exchange, with absolu

Arsine oxide, hydroxydimethyl-, cacodylate sodium salt; arsinic acid, dimethyl- sodium salt; cacodylic acid, sodium salt; [(dimethylarsino)oxy]-sodium-As- oxide; hydroxydimethylarsine oxide, sodium salt; sodium dimethylarsinate; sodium dimethylarsonate; Alkarsodyl; Arsecodile Arsicodile; Arsycodile; Bolls Eye; Phytar 560; Rad-E-Cate 25; Silvisar Table 2: Physical properties of dimethylarsinic acid and its sodium salt and of methanearsonic acid monosodium and disodium salts Compound Melting point ( C) Description Solubility (g/litre) Dimethylarsinic 195-196 white, very soluble in water (2000), acid crystalline ethanol; insoluble in ether solid Methanearsonic 132-139 crystalline very soluble in water (1000), acid disodium solid methanol; insoluble in organic salt solvents Methanearsonic 115-119 crystalline soluble in water (570), methanol; acid mono- solid insoluble in organic solvents sodium salt Sodium 200 crystalline very soluble in water (2000); cacodylate solid soluble in ethanol ...

This graph shows the total number of publications written about Arsanilic Acid by people in Harvard Catalyst Profiles by year, and whether Arsanilic Acid was a major or minor topic of these publication ...

Arsenobetaine, arsenocholine, monomethylarsonic acid, dimethylarsinic acid, arsenous (III) acid, arsenic (V) acid. The concentration of speciated arsenics is determined by using high performance liquid chromatography (HPLC) to separate the species coupled to an ICP-DRC-MS to detect the arsenic species. This analytical technique is based on separation by anion-exchange chromatography (IC), followed by detection using quadrupole ICP-MS technology, and includes DRC™ technology (Baranov VI et al., 1999), which minimizes or eliminates many argon-based polyatomic interferences (Tanner S et al., 2000) will require 0.5 mL of urine. Arsenic species column separation is largely achieved due to differences in charge-charge interactions of each negatively-charged arsenic component in the mobile phase, with the positively-charged quaternary ammonium groups bound at the columns solid-liquid interface. Upon exit from the column, the chromatographic eluent goes through a nebulizer, where it is converted into ...

Acute promyelocytic leukemia (APL) is definitely a uncommon disease accounting for just 5%C10% of pediatric severe myeloid leukemia (AML) and less than 1000 situations occur annually in america across all age ranges. introduce and increase the advantage of brand-new therapies. Right here, we review the display, scientific features, pathogenesis, and treatment developments in pediatric APL. fusion gene [1,2]. The proteins item continues to be discovered as the principal drivers in charge of almost all complete situations of APL, and enhanced understanding of the mechanism by which leads to APL has drastically altered the therapeutic approach and outcomes for this disease. Patients with APL now experience the highest cure rates of pediatric acute myeloid malignancies, with an average overall survival (OS) near 95% and event-free survival (EFS) of 90% due to the combined use of allretinoic acid (ATRA) and arsenic trioxide (ATO) to induce the terminal differentiation GDC-0339 of APL blasts [3,4]. ...

Arsenic (As) is an ubiquitous chemical element that occurs in nature in the form of organic and inorganic compounds, and its harmful effects are well known and described. It is well known that inorganic arsenic (III and V) compounds are more toxic than organic compounds. Also the bioavailability of arsenic from different chemical compounds varies. Organic forms of arsenic, which are most commonly found in fish and seafood, undergo little biotransformation after consumption and are excreted from the body in virtually unchanged form. On the other hand, inorganic arsenic compounds are well absorbed and metabolized. Adverse effects of inorganic arsenic Long-term exposure to arsenic derived from inorganic compounds results in an increased risk of developing various types of cancer, including skin, bladder, lung, kidney, liver and prostate cancer. In addition, exposure to inorganic arsenic is accompanied by disorders of gastrointestinal, cardiovascular, blood, respiratory, neurological, immune, ...

Arsenicals are relatively weak poisons and the sisters being aware of this used two poisons, strychnine and cyanide, which dwarf arsenicals in their effectiveness. (1) Even though arsenic wasnt the agent of death arsenic and old lace has a much nicer artistic ring to it then strychnine and old lace or cyanide and old lace. Regardless, arsenic is a much feared material, resulting in what Ralph Zangaro calls arsenophobia. (2). No debate arsenic is a poison, but it has been used medicinally for more than 3000 years to treat human illnesses, including infectious diseases and malignancies. In recent times, Chinese researchers reported that arsenic trioxide induced remissions in patients with promyelocytic leukemia, a cancer of the blood, including those who had relapsed after other prior therapy. (3) In another report concerning a long-term study in China, doctors may appear to have safely and successfully treated patients with cancer of the blood and bone marrow with a combination of arsenic ...

Ingestion of arsenic is relatively common in the setting of homicide and is occasionally used in deliberate self-poisoning. Arsine gas and CCA exposure are not uncommon industrial exposures. Most organs can be involved and the diagnosis may not be obvious. \\ \\ Arsenic is a classic poison; implicated in the deaths of Tchaikovsky and Napoleon. It has also been used as a therapeutic substance since ancient times. It has been used in traditional Chinese medicines and most recently as a chemotherapeutic agent for the treatment of acute promyelocytic leukaemia. Chronic arsenic poisoning is a major public health crisis and an environmental disaster in Bangladesh and West Bengal, due to the contamination of ground water that affects millions of people. These chronic problems are beyond the scope of this course. \\ \\ Arsenic exists in many forms: arsine gas, elemental arsenic, inorganic oxides and organic arsenic. Acute arsenic poisoning is rare. The elemental form of arsenic is non-toxic but the ...

Composition and optical absorption of thin films of GaAs(Ti) and GaAs, deposited by sputtering on glass substrates under different process conditions, have been investigated. The thin films obtained are typically 200 nm thick. ToF-SIMS measurements show a quite constant concentration and good uniformity of Ti profiles along the GaAs(Ti) layers in all cases and EPMA results indicate that Ti content increases with the substrate temperature in the sputtering process. Measurements of the transmittance and reflectance spectra of the GaAs and GaAs(Ti) thin films have been carried out. In the optical characterization of the films it is found that optical absorption is enhanced in all samples containing Ti. The determination of the optical gap from the optical absorption, shows optical gap variations from 1.15 to 1.29 eV in the GaAs thin films, and from 0.83 to 1.13 eV in the GaAs(Ti) thin films. The differences in absorption and EgTAUC observed between samples of GaAs and GaAs(Ti) are consistent with ...

Orpiment is mainly used externally as louse-killer, a cure for scabies, for snake bites, insect stings, and skin diseases (Pharmacopeia of China, 2005; Koch et al., 2007). Orpiment is included in Quingyi Piwen Dan, a preparation of detoxication and laxative use with other 74 herbs, but its use alone in oral remedies is not common. Nanoparticles of orpiment have been prepared, and they were effective in killing leukemia K562 cells in vitro (Lin et al., 2007). [...] Realgar is less toxic as compared to arsenic trioxide, and is now used alone or in combination for hematologic malignancies (Lu et al., 2002; Shen et al., 2004). Recently, Realgar-Indigo naturalis formulae have been shown to be very effective against promyelocytic leukemia (Wang et al., 2008). Realgar acts as the principal component of the formula, whereas other plant active ingredients (such as indirubin and trashinone IIA) serve as adjuvant ingredients, in inducing acute promyelocytic leukemia cell differentiation and the ...

In the late 19th century, derivatives of aniline such as acetanilide and phenacetin emerged as analgesic drugs, with their cardiac-suppressive side effects often countered with caffeine.[26] During the first decade of the 20th century, while trying to modify synthetic dyes to treat African sleeping sickness, Paul Ehrlich - who had coined the term chemotherapy for his magic bullet approach to medicine - failed and switched to modifying Béchamps atoxyl, the first organic arsenical drug, and serendipitously obtained a treatment for syphilis - salvarsan - the first successful chemotherapy agent. Salvarsans targeted microorganism, not yet recognized as a bacterium, was still thought to be a parasite, and medical bacteriologists, believing that bacteria were not susceptible to the chemotherapeutic approach, overlooked Alexander Flemings report in 1928 on the effects of penicillin.[27]. In 1932, Bayer sought medical applications of its dyes. Gerhard Domagk identified as an antibacterial a red azo ...

Acute promyelocytic leukemia (APL) is characterized by a t(15;17) translocation that yields a PML/RARA fusion protein. Expression of PML/RARA, a potent transcriptional repressor, induces APL in mice. Both retinoic acid (RA) and arsenic trioxide directly target PML/RARA-mediated transcriptional repre …

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). APL is treated with different medicines than other types of AML.

Learn about symptoms and treatments for acute promyelocytic leukemia (APL), a cancer in which the bone marrow produces too many promyelocytes.

Treatment of acute promyelocytic leukemia (APL), the M3 subtype of acute myeloid leukemia (AML), differs from the usual AML treatment. Learn more here.

The treatment of most cases of acute promyelocytic leukemia differs from usual AML treatment. Learn more about APL treatment here.

This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13

Compare risks and benefits of common medications used for Acute Promyelocytic Leukemia. Find the most popular drugs, view ratings, user reviews, and more...

This application note demonstrates the ability to measure various arsenic forms in white rice, building upon previous work using HPLC/ICP-MS. The results described demonstrate that the combination of Flexar HPLC and NexION ICP-MS is suitable for the analysis of different forms of arsenic in white rice.

Rabbit Polyclonal to ACRO (H chain, Cleaved-Ile43) TL may become an effective restorative agent for the treatment of MDS (25), several 162808-62-0 types of human being pancreatic (26) and adrenal (27) malignancy, and Capital t cell lymphocytic leukemia (28) via inducing cell apoptosis through the service of caspase-3 and generation of reactive oxygen varieties (ROS) (25C27). Although particular combination treatments including As2O3 and additional providers, are ongoing for several types of human being tumor, few As2O3 combination treatments are clinically effective. These include combination therapy of As2O3 with ascorbic acid in nonrefractory APL hematologic malignancies and multiple myeloma (18), but not in additional AML except nonrefractory APL, acute lymphoid leukemia (18), chronic myeloid leukemia and chronic lymphoid leukemia (18). The use of phase 2 combination therapy with 162808-62-0 As2O3 and gemtuzumab ozogamicin for the treatment of MDS and secondary AML offers been found to have ...

Acute promyelocytic leukaemia cant be diagnosed without doing tests. This involves a routine blood test, where a small sample is taken and examined in a laboratory.. The results of the test will reveal whether there are leukaemia cells in the blood. Almost all patients with acute leukaemia have a high white cell count, almost entirely made up of leukaemia cells. Usually the numbers of normal red and white blood cells and platelets are all reduced.. Modern blood cell counting machines, which are usually used to help diagnose each patients type of leukaemia more precisely, cannot distinguish between APL and other types of AML. More sophisticated genetic tests are used to do this. More sophisticated genetic tests are used to do this.. If APL is suspected some parts of a patients treatment may be started immediately. This is because APL is a very aggressive blood cancer and there is a strong risk that patients may suffer from fatal bleeding if not treated properly.. Most patients will also have a ...

There were no treatment-related effects on mortality. In most cases there were no effects on body weight although in one replicate experiment a decrease in weight was observed in the high dose group and body weight gain was decreased over the 2 week post-exposure. Spleen weights were increased in all gallium arsenide treated groups while thymus weights were decreased at the high dose (Table 1). A dose-response increase in lung weights occurred following treatment but none of the individual values were significant. The lungs were characterized by darkened areas consisting of lymphocyte and macrophage infiltration. There was a tendency (not significant) for a treatment-related decrease in peripheral leukocyte counts (Table 1) which was associated with a significant decrease in peripheral lymphocyte counts in the 200 mg/kg treatment group (not shown).. The immune and bone marrow studies are also summarized in Table 1. Gallium arsenide suppressed the following immune parameters dose- dependently: ...

The follow-up time for survival of each cohort was 36 months from admission. Furthermore, environmental factors, activity and action by the individual may influence a persons health status [38]. To open a specific report, select the desired year and click the Submit button next to the report. Number of nursing homes: 15,600 (2016) Proportion of nursing homes with for-profit ownership: 69.3% (2016) Number of licensed beds: 1.7 million (2016) Source: Long-Term Care Providers and Services Users in the United States, 2015-2016, Appendix III. The changes in health score were significant in all categories except the lowest score of 1. The Depression Rating Scale (DRS) is a 15-point scale ranging from 0-14. 2003, 51: 96-100. A considerable number died within the first year, while others lived longer than 3 years in nursing homes. The latter group may have benefitted more from receiving home care and rehabilitation and thus might have deferred nursing home placement. J Am Geriatr Soc. Reprints. The ...

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Most vertebrate and seed RNA and little DNA infections suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking web host mRNA structure. replication component of picornaviruses (Martnez-Salas et al., 2015; Goodfellow et al., 2003; Steil and Barton, 2009). The genomes of RNA infections are also at the mercy of a variety of poorly grasped mutational and compositional constraints, with significant variability in G?+?C articles and the obvious avoidance of specific dinucleotides (the usage of two Icotinib adjacent nucleotides within a linear series), such as for example CpG and UpA (Simmonds et al., 2013; Karlin et al., 1994; Rima and McFerran, 1997). At least partly, this design of under-representation could be shared with the hosts they infect where suppression of CpG and UpA is certainly popular. In coding sequences of all microorganisms, TpA (UpA in RNA) is certainly under-represented while vertebrate and seed genomes additionally present solid suppression of CpG dinucleotides ...

Find all books from Musik: Samanta, Gautam - Preservation of Arsenic Species. At find-more-books.com you can find used, antique and new books, COMPARE results and immediately PURCHASE your selection at the best price. 9781843399698