TY - JOUR. T1 - Indigenous American Ancestry is Associated with arsenic methylation efficiency in an admixed population of northwest Mexico. AU - Gomez-Rubio, Paulina. AU - Klimentidis, Yann C.. AU - Cantu-Soto, Ernesto. AU - Meza-Montenegro, Maria M.. AU - Billheimer, Dean. AU - Lu, Zhenqiang. AU - Chen, Zhao. AU - Klimecki, Walter T.. N1 - Funding Information: Received 27 May 2011; accepted 1 August 2011. The authors acknowledge Michael Kopplin for performing the arsenic speciation analyses. P.G.-R. was supported by a fellowship from the Mexican National Council for Science and Technology (CONACyT) under the UA-CONACyT partnership. This study was supported by the NIEHS Superfund Basic Research Program (ES04940) and a NIEHS Center Grant (ES006694). Address correspondence to Walter T. Klimecki, DVM, PhD, 1657 E Helen St, RM319, Thomas Keating Bldg. Tucson, AZ 85721, USA. E-mail: [email protected] PY - 2012. Y1 - 2012. N2 - Many studies provide evidence relating lower human arsenic ...
Pilot study indicates that dogs eating rice-based dry dog foods could be at risk for chronic arsenic exposure. Rice-consumption is considered a risk factor for chronic arsenic toxicity in humans. A pilot study conducted within the DogRisk research group at the University of Helsinki found that dogs eating rice-based dry dog foods had higher hair arsenic levels than dogs whose diet did not contain rice. The study compared hair arsenic levels from seven dogs that were eating rice-based (having rice as first or second ingredient) dry dog foods and nine dogs whose diet did not contain any rice. All dogs were of the breed Staffordshire bull terrier and had been eating their diets for a minimum of one year prior to the study.. - Considering that dogs often eat the same food daily for long periods of time, sometimes even their whole lives, we need to acknowledge the risk for long-term accumulation of contaminants such as toxic metals. Arsenic is widespread in the environment and accumulates especially ...
Article Policy intervention for arsenic mitigation in drinking water in rural habitations in India: achievements and challenges. This article provides updated status of the arsenic affected rural habitations in India, summarizes the policy initiative...
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Abstract: Dietary arsenic exposure and chronic health outcomes are of interest, due in part to increased awareness and data available on inorganic arsenic levels in some foods. Recent concerns regarding levels of inorganic arsenic, the primary form of arsenic of human health concern, in foods are based on extrapolation from adverse health effects observed at high levels of inorganic arsenic exposure; the potential for the occurrence of these health effects from lower levels of dietary inorganic arsenic exposure has not been established. In this review, longitudinal cohort studies are evaluated for their utility in estimating dietary inorganic arsenic exposure and quantifying statistically reliable associations with health outcomes. The primary limiting factor in longitudinal studies is incomplete data on inorganic arsenic levels in foods combined with the aggregation of consumption of foods with varying arsenic levels into a single category, resulting in exposure misclassification. Longitudinal ...
Arsenic contamination takes serious turn in Narail. NARAIL June 12 : Arsenic contamination has taken a serious turn in all the three upazilas of the district in recent times, reports BSS. The number of arsenic affected people is increasing in Narail district day by day. Kalia upazila is a severely arsenic affected area in district. About 85 per cent tube-wells in the area are marked with red paint to warn the people that the waters of these tube-wells are contaminated by arsenic, Md Ahsan Habib, Upazila Nirbahi Officer, Kalia said.. In Kalia upazila the waters of 11,304 tube-wells have been tested, of which contamination of arsenic beyond permissible level has been detected in 8,507 tube- wells.In Lohagora upazila, waters of 1,023 tube-wells have been tested, of which contamination of arsenic has been detected in 696 tube-wells. In Narail Sadar upazila the waters of 1,269 tube-wells have been tested and of which contamination of arsenic has been detected in 499 tube-wells.. At least 55 persons ...
TY - JOUR. T1 - Arsenic exposure and methylation efficiency in relation to oxidative stress in semiconductor workers. AU - Pan, Chih Hong. AU - Lin, Ching Yu. AU - Lai, Ching Huang. AU - Jeng, Hueiwang Anna. PY - 2020/5/1. Y1 - 2020/5/1. N2 - This study examined associations between oxidative stress and arsenic (As) exposure and methylation efficiency in semiconductor workers. An As-exposed group (n = 427) and a control group (n = 91) were included. The As-exposure group (n = 427) included 149 maintenance staff members and 278 production staff members representing high As exposure and low As exposure, respectively. The control group included 91 administrative staff members with no or minimal As exposure. An occupational exposure assessment was conducted to assess personal As exposure by measuring As concentrations in urine, hair, and fingernails of the subjects. Urinary As(III), As(V), monomethylarsonic (MMA), and dimethylarsinic acid (DMA) were quantified to assess an internal dose of inorganic ...
To date, we have analyzed 8334 hand tubewell water samples from 1374 villages/Para/wards in 79 GPs/ Municipal area from 17 blocks of this district. Table I shows the distribution of arsenic in tubewell water from South 24 Parganas district. Figure I shows the groundwater arsenic contamination status in 17 blocks of South 24 Parganas with Pie-diagram distribution. Table I shows that arsenic concentration above 10 µg/L in 3500 (42%) hand tubewells and in 2359 (28.3%) above 50 µg/Land 547 (6.6%) had arsenic concentrations above 300µg/L. From the above analysis, it appears that groundwater in 12 block contains arsenic above WHO guideline value of arsenic in drinking water (10 µg/L) and 11 blocks exceeds Indian standard value for As in drinking water (50 µg/L). Arsenic level above 1000µg/L was found in 30 tubewells; the maximum arsenic contamination level found in this district is 3700µg/L in the Baruipur block. In blocks Diamond Harbour, Gosaba, Joynagar II and Thakurpukur all the tubewells ...
TY - BOOK. T1 - Arsenic Exposure and Health Effects IV. T2 - Arsenic exposure, null genotypes of glutathione s-transferase m1, t1 and p1, and risk of carotid atherosclerosis among residents in the Lanyang Basin of Taiwan. AU - Chappell, W.R.. AU - Abernathy, C.O.. AU - Calderon, R.L.. AU - Chiou, Hung-Yi. AU - Wang, I.H.. AU - Hsueh, Yu-Mei. AU - Chiou, S. T.. AU - Chou, Yi Li. AU - Teh, Hee-Wen. AU - Chen, Chien Jen. PY - 2001. Y1 - 2001. N2 - This collected volume of authoritative articles represents the state-of-the-art in arsenic research. Arsenic experts from around the world, participants in the Fourth International Conference on Arsenic Exposure and Health Effects organized by the Society of Environmental Geochemistry and Health in 2000, present their critical findings.A vital contribution to arsenic study and policy making, this volume examines the global impact of the toxin and discusses arsenic in the environment, mechanisms of arsenic metabolism and carcinogenesis, water treatment ...
The Binational Arsenic Exposure Survey (BAsES) was designed to evaluate probable arsenic exposures in selected areas of southern Arizona and northern Mexico, two regions with known elevated levels of arsenic in groundwater reserves. This paper describes the methodology of BAsES and the relationship between estimated arsenic intake from beverages and arsenic output in urine. Households from eight communities were selected for their varying groundwater arsenic concentrations in Arizona, USA and Sonora, Mexico. Adults responded to questionnaires and provided dietary information. A first morning urine void and water from all household drinking sources were collected. Associations between urinary arsenic concentration (total, organic, inorganic) and estimated level of arsenic consumed from water and other beverages were evaluated through crude associations and by random effects models. Median estimated total arsenic intake from beverages among participants from Arizona communities ranged from 1.7 to 14.1 µg
To date, we have analyzed 29668 hand tubewell water samples from 1721 villages / wards in 250 GPs/ Municipal area from all 26 blocks of the district (Table I). Figure I shows the groundwater arsenic situation in each block of Murshidabad with Pie-diagram distribution. We observed arsenic concentration above 10 µg/L in 15953 (53.8%) hand tubewells and in 7911 (26.7%) above 50 µg/L and 1337 (4.5%) of the tubewells had arsenic concentrations above 300µg/L. In Murshidabad the number of villagers where we found arsenic concentration above 10, 50 and 300 µg/L are 1320, 971 and 281 respectively; and 25, 24 and 17 blocks were found to be contaminated with arsenic levels above 10, 50 and 300 µg/L. Arsenic level above 1000µg/L was found in 71 tubewells; the maximum arsenic contamination level found in this district is 3003µg/L in the Nawda and Raghunathganj I blocks. ...
Arsenic contamination takes serious turn in Chandpur. CHANDPUR, June 25: Arsenic contamination has taken a serious turn in Chandpur district recently.. This was disclosed by Md. Sadeq Hossain, Executive Engineer of the local Public Health Engineering Department, in an exclusive talk with this correspondent recently.. About 1.25 lakh shallow tube-wells of all the eight upazilas of the district have already been sealed as the waters of those contain arsenic beyond permissible limits which are very much harmful to human body, he added. He disclosed that on an average 98 per cent shallow tube-wells of the district are arsenic contaminated.. A survey shows that 96 per cent tube-wells in Hajiganj, 98 per cent tube-wells in Faridganj, Shahrasti and Kochua, 85 per cent tube-wells in Haimchar and 80 per cent tube-wells in Matlab Sadar and newly created Matlab North upazilas are arsenic contaminated.. It is officially learnt that at present 5,000 people, mostly old men, women and children have been ...
Arsenic. Agency for Toxic Substances and Disease Registry website. Available at: http://www.atsdr.cdc.gov/substances/toxsubstance.asp?toxid=3. Accessed January 29, 2021. Arsenic and drinking water from private wells. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/healthywater/drinking/private/wells/disease/arsenic.html. Accessed January 29, 2021. Arsenic-ToxFAQs. Agency for Toxic Substances and Disease Registry website. Available at: http://www.atsdr.cdc.gov/toxfaqs/tfacts2.pdf. Accessed January 29, 2021. Acute arsenic poisoning. EBSCO DynaMed website. Available at: http://www.dynamed.com/topics/dmp~AN~T114977/Chronic-arsenic-poisoning . Accessed January 29, 2021. Chen Y, Graziano JH, Parvez F, et al. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study. BMJ. 2011;342:d2431. Chronic arsenic poisoning. EBSCO DynaMed website. Available at: ...
Gilbert-Diamond, Diane ; Cottingham, Kathryn L ; Gruber, Joann F ; Punshon, Tracy ; Sayarath, Vicki ; Gandolfi, A Jay ; Baker, Emily R ; Jackson, Brian P ; Folt, Carol L ; Karagas, Margaret ...
Emerging data indicate that rice consumption may lead to potentially harmful arsenic exposure. However, few human data are available, and virtually none exist for vulnerable periods such as pregnancy. Here we document a positive association between rice consumption and urinary arsenic excretion, a biomarker of recent arsenic exposure, in 229 pregnant women. At a 6-mo prenatal visit, we collected a urine sample and 3-d dietary record for water, fish/seafood, and rice. We also tested womens home tap water for arsenic, which we combined with tap water consumption to estimate arsenic exposure through water. Women who reported rice intake (n = 73) consumed a median of 28.3 g/d, which is ∼0.5 cup of cooked rice each day. In general linear models adjusted for age and urinary dilution, both rice consumption (g, dry mass/d) and arsenic exposure through water (μg/d) were significantly associated with natural log-transformed total urinary arsenic ( ...
Ingestion of arsenic is relatively common in the setting of homicide and is occasionally used in deliberate self-poisoning. Arsine gas and CCA exposure are not uncommon industrial exposures. Most organs can be involved and the diagnosis may not be obvious. \\ \\ Arsenic is a classic poison; implicated in the deaths of Tchaikovsky and Napoleon. It has also been used as a therapeutic substance since ancient times. It has been used in traditional Chinese medicines and most recently as a chemotherapeutic agent for the treatment of acute promyelocytic leukaemia. Chronic arsenic poisoning is a major public health crisis and an environmental disaster in Bangladesh and West Bengal, due to the contamination of ground water that affects millions of people. These chronic problems are beyond the scope of this course. \\ \\ Arsenic exists in many forms: arsine gas, elemental arsenic, inorganic oxides and organic arsenic. Acute arsenic poisoning is rare. The elemental form of arsenic is non-toxic but the ...
Spirulina is blue - green algae that grow both in fresh and salt water. For many years, the alga has used for various health purposes around the world. This nutrient-rich alga is a natural supplement that provides amazing health benefits to the users. Here are the benefits of Spirulina.. #1. Detoxing properties The studies show that regular intake of Spirulina can effectively detox heavy metals such as Arsenic. It has been demonstrated that chronic Arsenic toxicity is common in most parts of the world. Millions of people consume Arsenic through drinking water. Apparently, there is no specific treatment for arsenic toxicity. However, the clinical trials have proven that Spirulina can significantly reduce the level of toxicity in the body.. #2. Packed with essential nutrients Our bodies require essential nutrients for proper functioning. Fortunately, Spirulina is rich in essential nutrients and low in calories. The algae manufacture its food through photosynthesis thus making it rich in vital ...
Spirulina is blue - green algae that grow both in fresh and salt water. For many years, the alga has used for various health purposes around the world. This nutrient-rich alga is a natural supplement that provides amazing health benefits to the users. Here are the benefits of Spirulina.. #1. Detoxing properties The studies show that regular intake of Spirulina can effectively detox heavy metals such as Arsenic. It has been demonstrated that chronic Arsenic toxicity is common in most parts of the world. Millions of people consume Arsenic through drinking water. Apparently, there is no specific treatment for arsenic toxicity. However, the clinical trials have proven that Spirulina can significantly reduce the level of toxicity in the body.. #2. Packed with essential nutrients Our bodies require essential nutrients for proper functioning. Fortunately, Spirulina is rich in essential nutrients and low in calories. The algae manufacture its food through photosynthesis thus making it rich in vital ...
Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Global DNA hypomethylation occurs during arsenic-induced malignant transformation in rodent liver cells. DNA hypomethylation can increase gene expression, particularly when occurring in the promoter region CpG sites, and may be a non-genotoxic mechanism of carcinogenesis. Thus, in the present study liver samples of male mice exposed to 0 (control) or 45 p.p.m. arsenic (as NaAsO2) in the drinking water for 48 weeks were analyzed for gene expression and DNA methylation. Chronic arsenic exposure caused hepatic steatosis, a lesion also linked to consumption of methyl-deficient diets. Microarray analysis of liver samples showed arsenic induced aberrant gene expression including steroid-related genes, cytokines, apoptosis-related genes and cell cycle-related genes. In particular, the expression of the estrogen receptor-α (ER-α), and cyclin D1 genes were markedly increased. RT-PCR and ...
The WHO recommended value of arsenic contamination in water is 0.01 mg/l, while the maximum permissible limit for Bangladesh and India has been fixed at 0.05 mg/l. In the DCH-SOES survey, less than 0.01 mg/l arsenic concentration was detected in 46% or 2803 out of 6101 water samples while above the WHO recommended value (0.01 mg/l) was found in the rest 54% or 3298 samples. On the other hand, arsenic concentration at less than the permissible limit (0.05 mg/l) was detected in 62% or 3783 samples, while above the limit was found in the rest 38% or 2318 water samples. Arsenic contamination at higher level than the WHO recommended value was found in the tube-wells of 52 districts out of the 60 surveyed. Of these, the level of arsenic presence exceeds the maximum permissible limit in the tube-wells water of 41 districts. In 11 districts, the level of arsenic concentration was found more than the WHO recommended value, but less than the maximum permissible limit. That means, highest 0.05 mg/l exist ...
TY - JOUR. T1 - Mode of action for inorganic arsenic toxicity and carcinogenesis. AU - Dodmane, Puttappa R.. AU - Arnold, Lora L.. AU - Cohen, Samuel M.. PY - 2014/11/1. Y1 - 2014/11/1. N2 - Inorganic arsenic (iAs) at high doses is a known human carcinogen, inducing tumors of the skin, urinary bladder, and lung. It is also associated with noncancer toxicities. An understanding of the mode of action (MOA) for arsenic-induced effects is needed to develop a scientifically-based risk assessment. To determine an MOA for iAs induced toxicities, it is necessary to understand the metabolism, kinetics, cell transport, and interaction with specific proteins of iAs. Based on in vitro investigations using animal and human cells, studies from animal models, and clinical and epidemiological studies, we have proposed an MOA involving formation of sufficient levels of reactive trivalent metabolites which interact with critical free sulfhydryl groups, leading to cytotoxicity and regenerative cell proliferation. ...
Introduction: Human are exposed to arsenic threats in several ways. Our drinking water for instance, can be hazardous due to the contamination of arsenic-based pesticide and herbicide into our water supply. The most vulnerable part of our body due to ingestion of arsenic is our gastrointestinal system. Thus, the aim of this study was to determine the effects of chronic exposure to organic arsenic (Monosodium methylarsonate, MSMA) on the surface topography of rats colonic mucosa by using scanning electron microscope (SEM). Materials and Methods: 30 Sprague Dawley rats were given daily oral gavage of MSMA 42.13 mg/kg, which is 1/30 LD50, and 30 Sprague Dawley rats acted as control. 10 exposed rats and 10 control rats were sacrificed at regular intervals (2 months, 4 months and 6 months) and their colon specimens were examined by SEM. Results: In the control group, the colonic mucosa appeared normal with uniform size individual glandular units and has a central crypt orifice. The goblet cells were ...
Arsenic dissolved in water is acutely toxic and can lead to a number of health problems. Long-term exposure to arsenic in drinking-water causes increased risks of cancer in the skin, lungs, bladder and kidney. It also leads to other skin-related problems such hyperkeratosis and changes in pigmentation. Consumption of arsenic also leads to disturbance of the cardiovascular and nervous system functions and eventually leads to death. These health effects sometimes collectively referred to as arsenicosis have been demonstrated in many studies. Increased risks of lung and bladder cancer and of arsenic-associated skin lesions have been reported for consuming drinking-water with arsenic concentrations equal to or greater than 50 parts per billion (or microgram per liter). (WHO Environmental Health Criteria, No. 224: Arsenic).. Arsenicosis is recognizable from skin colour changes, blotches all over the face and body, hyper pigmentation on the chest and upper arms, hard patches on palms and soles of the ...
Millions now suffer the effects of chronic arseniasis related to environmental arsenic exposure. The biological mechanisms responsible for arsenic-induced toxicity and especially chronic effects, including cancer, are not well known. The U.S. Armed Forces Institute of Pathology (AFIP) is participati …
Arsenic (As) is an ubiquitous chemical element that occurs in nature in the form of organic and inorganic compounds, and its harmful effects are well known and described. It is well known that inorganic arsenic (III and V) compounds are more toxic than organic compounds. Also the bioavailability of arsenic from different chemical compounds varies. Organic forms of arsenic, which are most commonly found in fish and seafood, undergo little biotransformation after consumption and are excreted from the body in virtually unchanged form. On the other hand, inorganic arsenic compounds are well absorbed and metabolized. Adverse effects of inorganic arsenic Long-term exposure to arsenic derived from inorganic compounds results in an increased risk of developing various types of cancer, including skin, bladder, lung, kidney, liver and prostate cancer. In addition, exposure to inorganic arsenic is accompanied by disorders of gastrointestinal, cardiovascular, blood, respiratory, neurological, immune, ...
Arsenic biochemistry refers to biochemical processes that can use arsenic or its compounds, such as arsenate. Arsenic is a moderately abundant element in Earths crust, and although many arsenic compounds are often considered highly toxic to most life, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms. This pattern is general for other related elements, including selenium, which can exhibit both beneficial and deleterious effects. Arsenic biochemistry has become topical since many toxic arsenic compounds are found in some aquifers, potentially affecting many millions of people via biochemical processes. The evidence that arsenic may be a beneficial nutrient at trace levels below the background to which living organisms are normally exposed has been reviewed. Some organoarsenic compounds found in nature are arsenobetaine and arsenocholine, both being found in many marine organisms. Some ...
Arsenic is carcinogenic, possibly partly through epigenetic mechanisms. We evaluated the effects of arsenic exposure and metabolism on DNA methylation. Arsenic exposure and methylation efficiency in 202 women in the Argentinean Andes were assessed from concentrations of arsenic metabolites in urine (inorgani
Arsenic is found in multiple forms, some of which are more toxic to humans than others. In Alaska, most arsenic in groundwater is likely derived from inorganic arsenic that occurs naturally in the Earths crust, most commonly as the mineral arsenopyrite. When arsenopyrite oxidizes into its elemental components (similar to the way iron rusts) and those components enter the groundwater system, the resulting arsenic, as pentavalent arsenic [As(V) or arsenate] and trivalent arsenic [As(III) or arsenite], is toxic to humans. Arsenite is both more harmful and more mobile in groundwater than arsenate. Soils in some parts of Alaska have high concentrations of inorganic arsenic, which can leach into groundwater and render private well water unsafe for consumption. Arsenic in surface water, however, tends to bind with iron oxide and organic material, making it less mobile, and therefore, less likely to reach drinking water sources. Arsenic also accumulates in food crops grown in arsenic-rich soil or ...
The guideline value for inorganic arsenic in drinking water was reduced from 50 μg/L to 10 μg/L by the World Health Organization (WHO) in 1993. Nonetheless, many countries, particularly developing countries, still use the 50 μg/L value as standard for arsenic partially because of lack of adequate analytical instruments for lower arsenic concentrations in water.. Elevated concentrations of arsenic in drinking water (above 50 μg/L) have been reported in several countries, including Argentina, Chile, China, Mongolia, Taiwan, Nepal, Japan, Mexico, Poland, Vietnam, and the USA. Local-scale problems of arsenic contamination of groundwater have been reported by some countries, and new cases are continually discovered - groundwater contaminated by arsenic can be found all over the world.. To date, the globally worst-affected areas are located in Bangladesh and West Bengal (India), where arsenic in groundwater has been documented at concentrations up to 3,200 μg/L. Moreover, in some districts of ...
epigenetic alteration behindenhanced mitochondrial biogenesis in chronic arsenic exposure. An extensive case-control study was conducted with 390 study participants (unexposed, exposed without skin lesion, exposed with skin lesion and exposed skin tumour) from highly arsenic exposed areas ofWest Bengal, India. Methylation specific PCRrevealed significant promoter hypomethylation oftwo key biogenesis regulatory genes, PGC1αandTfam in arsenic exposed individuals and also in skin tumour tissues. Linear regression analysis indicated significant negative correlation between urinary arsenic concentration and promoter methylation status. Increased expression of biogenesis regulatory genes wasobtained by quantitative real-time PCR analysis. Moreover, altered mitochondrial fusion-fission regulatory gene expression was also observed in skin tumour tissues. miR663, having tumour suppressor gene like function was known to be epigenetically regulated through mitochondrial retrograde signal. Promoter ...
This blood test is used to measure Arsenic levels. Arsenic is a common cause of acute poisoning through heavy metals. Arsenic enters the environment through the smelting of copper, zinc and lead and is released through the manufacturing of certain chemicals. Pesticides that contain arsenic, when manufactured, release arsine gas. Arsenic has been found in water supplies around the world, which has the potential to leach into seafood. Arsenic is found in rat poisoning, fungicides and products used to protect wood. Arsenic toxicity affects the blood, kidneys, skin, digestive tract and central nervous system ...
Compounds of arsenic were recognized as highly toxic long before arsenic was even recognized as an element in 1649 (by Schroeder, a German pharmacist). Nero used arsenic to poison Britannicus in 55 AD to secure the Roman throne. In 17th century France, white arsenic (As2O3) was known as poudre de succession (inheritance powder). Today, approximately 90 percent of all arsenic used in the US is used as a wood preservative. Arsenic is also used in electronics (gallium arsenide) and continues to be used in agricultural chemicals (pesticides, insecticides, herbicides, algaecides, fungicides and growth stimulants for plants and animals). Arsenic, being an element, is never destroyed once released into the environment. It will be with us forever.. Arsenic consumption is linked to a number of adverse health effects including skin, bladder and lung cancer. Oxygenated compounds of arsenic (arsenates: As+5 and arsenites: As+3) are soluble in water and, when ingested, mimic phosphates in the body. They can ...
BACKGROUND A large population in West Bengal, India has been exposed to naturally occurring inorganic arsenic through their drinking water. A cross-sectional survey involving 7683 participants of all ages was conducted in an arsenic-affected region between April 1995 and March 1996. The main focus of the study was skin keratoses and pigmentation alterations, two characteristic signs of ingested inorganic arsenic. Strong exposure-response gradients were found for these skin lesions. The study also collected limited information concerning respiratory system signs and symptoms, which we report here because increasing evidence suggests that arsenic ingestion also causes pulmonary effects. METHODS Participants were clinically examined and interviewed, and the arsenic content in their current primary drinking water source was measured. There were few smokers and analyses were confined to non-smokers (N = 6864 participants). RESULTS Among both males and females, the prevalence of cough, shortness of breath
Subsoil water contamination with arsenic is a burning global health issue. People experiencing exposure to contaminated water by arsenic throughout years can give rise to development of myriad clinical manifestations with a chief of arsenicosis which is the collective form of pigmentation and keratotic lesion of the skin. We surveyed over a population of above 500 people in West Bengal who are chronically exposed to arsenic at various doses through their drinking water throughout years which revealed a discreet variation in the development of such symptoms. This discrimination may be due to the error in metabolism which comes from the polymorphic association of genes particularly involved in arsenic metabolism. To check our hypothesis we conducted a case control study over 78 study subjects including control and arsenic exposed people, with different level of exposure, chosen from the Nadia district of West Bengal, India. Our result revealed that glutathione-S-transferase (GST) polymorphism is
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The control of arsenic, a toxic and carcinogenic element, is an important issue for all copper smelters. In this work, the reaction mechanism and distribution behavior of arsenic in the bottom blown copper smelting process (SKS process) were investigated and compared to the flash smelting process. There are obvious differences of arsenic distribution in the SKS process and flash process, resulting from the differences of oxygen potentials, volatilizations, smelting temperatures, reaction intensities, and mass transfer processes. Under stable production conditions, the distributions of arsenic among matte, slag, and gas phases are 6%, 12%, and 82%, respectively. Less arsenic is reported in the gas phase with the flash process than with the SKS process. The main arsenic species in gas phase are AsS (g), AsO (g), and As2 (g). Arsenic exists in the slag predominantly as As2O3 (l), and in matte as As (l). High matte grade is harmful to the elimination of arsenic to gas. The changing of Fe/SiO2 has slight
2000, describes a method for removing arsenic from fly ash, in which arsenic is recovered as scorodite. The first treatment stage of the arsenic-containing material is the oxidation of trivalent arsenic (As(lll)) into pentavalent arsenic (As(V)) with a gas containing sulphur dioxide and oxygen in oxidising conditions, in which arsenic does not precipitate. After this, arsenic is precipitated in atmospheric conditions, in which the Fe(III)/As(V) mole ratio is specified as 1. Precipitation is carried out either in one or several stages, but precipitation as scorodite demands the over-saturation of the solution, which is achieved by recycling scorodite crystals to the first precipitation reactors and simultaneously neutralising the suspension. A beneficial pH range is around 1-2 and this is maintained by feeding a suitable neutralising agent into the precipitation stage. In these conditions, arsenic can be precipitated to the level of 0.5 g/l. The final arsenic removal to a level below 0.1 mg/l is ...
Arsenic contamination of the environment is a worldwide health hazard. This research project focused on four areas: development and testing of low cost, field portable devices capable of measuring levels of arsenic at 10 μg L-1 or less; specific chemical techniques for such testing; creation of educational tools and techniques to allow operators who lack advanced chemistry training to perform accurate testing; and the determination and use of a biomarker in DNA as a cancer predictor in individuals exposed to environmental arsenic. The analytical techniques explored include: (1) the Gutzeit method of arsenic determination though arsine gas production, which was investigated in three experiments: measuring arsenic levels in soil samples, using Gutzeit-based kits using silver nitrate as a reactant for arsine gas, and sensitivity comparison of three commercial test kits over varying time periods up to twenty-four hours. (2) The molybdenum blue method, technologically quantified through three different
I was told that someone could die of arsenic toxicity from eating a lot of shrimps/prawns. Im sure a lot means A LOT. Could you explain how this could happen and what happens in the system, and how to avoid/cure it? Thanl you ...
The Blackfoot are a tribe of Native Americans who currently live in Montana and Alberta. They lived northwest of the Great Lakes and came to participate in Plains Indian culture. In Blackfoot mythology, the supernatural world is dominated by the Sun. The Sun or the Creator (Nah-too-si; Super powered or Holiness) is believed to have created the earth and everything in the universe. Nah-too-si is sometimes personified by the mystical Napi, or Old Man. Napi was said to have been sent by the Nah-too-si to teach people how to live a sinless life, like He and his wife, Ksah-koom-aukie, Earth Woman. Napi is said to have given the Blackfoot visions and, by implication, Blackfoot music. The numbers four and seven, the cardinal directions, the six principle points and center, are important in Blackfoot mythology. Communication is believed to occur between the supernatural world and Blackfoot through visions of guardian spirits, during which songs and ceremonies may be imparted, such as that of medicine ...
Ganga-Meghna-Bramhaputra basin is one of the major arsenic-contaminated hotspot in the world. To assess the level of severity of arsenic contamination, con
Background Chronic arsenic exposure is definitely associated with an increased risk of skin, bladder and lung cancers. were analyzed using random effects Tobit regression to account for repeated measures and 8-OHdG values below the detection buy 849773-63-3 limit. buy 849773-63-3 Results A consistent negative effect for APE1 was observed across water, toenail and urinary arsenic models. APE1 148 glu/glu + asp/glu genotype was connected with a reduction in logged 8-OHdG of 0.40 (95%CI -0.73, -0.07) in comparison to APE1 148 asp/asp. A link between total urinary arsenic and 8-OHdG was noticed among ladies using the GSTM1 null genotype however, not in ladies with GSTM1 positive. Among ladies with GSTM1 null, an evaluation of the next, third, and 4th quartiles of total urinary arsenic towards the 1st quartile led to a 0.84 boost (95% CI 0.27, 1.42), a 0.98 boost (95% CI 033, 1.66) and a 0.85 boost (95% CI 0.27, 1.44) in logged 8-OHdG, respectively. Zero effects between 8-OHdG and toenail taking in ...
Results for arsenic in groundwater (arsenic contamination) equipment from AdEdge, Apyron, ATOMISOL and other leading brands. Compare and contact a supplier near you on (health and safety) - Environmental XPRT
Rep. Rosa DeLauro (D-CT) introduced a bill in Congress on Thursday which would limit the amount of inorganic arsenic permitted in rice and rice-based foods. The R.I.C.E (Reducing food-based Inorganic Compounds Exposure) Act would require the Food and Drug Administration to set a maximum permissible level of inorganic arsenic in rice and food containing rice. Inorganic arsenic… Continue Reading. ...
The authors estimated the global burden of disease for bladder, lung, and skin cancers attributable to inorganic arsenic in food. The authors - 1) established dose response estimates by converting dose response estimates for water exposure to human dose; 2) estimated exposure using data on a common range of arsenic content for food crops grown in different parts of the world and dietary patterns in different parts of the world; 3) multiplied the dose-response slope factor with the estimated range of daily dietary inorganic arsenic exposure to characterize cancer risk; and 4) summed across different populations to estimate the global burden of a particular arsenic-induced cancer ...
5.1 Exposure data. Exposure of high levels of arsenic in drinking-water has been recognized for many decades in some regions of the world, notably in China, Taiwan (China) and some countries in Central and South America. More recently, it has been discovered that a number of other regions have drinking-water that is highly contaminated with arsenic. In most of these regions, the drinking-water source is groundwater, naturally contaminated from arsenic-rich geological formations. The primary regions where high concentrations of arsenic have been measured in drinking-water include large areas of Bangladesh, China and West Bengal (India) and smaller areas of Argentina, Australia, Chile, Mexico, Taiwan (China), the USA and Viet Nam. In some areas of Japan, Mexico, Thailand and other countries, mining, smelting and other industrial activities have contributed to elevated concentrations of arsenic in local water sources.. Levels of arsenic in affected areas may range from tens to hundreds or even ...
Exposure to arsenic, a common environmental toxin found in drinking water, leads to a host of neurological pathologies. We have previously demonstrated that developmental exposure to a low level of arsenic (50ppb) alters epigenetic processes that underlie deficits in adult hippocampal neurogenesis leading to aberrant behavior. It is unclear if arsenic impacts the programming and regulation of embryonic neurogenesis during development when exposure occurs. The master negative regulator of neural-lineage, REST/NRSF, controls the precise timing of fate specification and differentiation of neural stem cells (NSCs). Early in development (embryonic day 14), we observed increased expression of Rest, its co-repressor, CoREST, and the inhibitory RNA binding/splicing protein, Ptbp1, and altered expression of mRNA spliced isoforms of Pbx1 that are directly regulated by these factors in the male brain in response to prenatal 50ppb arsenic exposure. These increases were concurrent with decreased expression of
The result of this study demonstrates a dose-response relationship between inorganic arsenic exposure from drinking water and risk of hypertension. Despite the lack of previous individual exposure data and the lack of information on potential confounders other than those we controlled for, the association seems strong enough to support the possibility of a causal association. There is also good agreement with the observations from Taiwan.8 Although there was no comprehensive, systematic sampling of the water supplies of the study area, the existing water measurements permit a reasonably good assessment of arsenic exposure. Furthermore, the effect of various unknown factors, such as use of bottled water, would dilute the effect and lead to an underestimation of the association. Because our study subjects were recruited from villages in which residents had similar occupations, socioeconomic status, lifestyles, and dietary habits, including salt intake, the variation among subjects of these ...
In January 2016, the EU imposed a maximum limit of inorganic arsenic on manufacturers in a bid to mitigate associated health risks. Researchers at the Institute for Global Food Security at Queens have found that little has changed since this law was passed and that 50 percent of baby rice food products still contain an illegal level of inorganic arsenic.. This research has shown direct evidence that babies are exposed to illegal levels of arsenic despite the EU regulation to specifically address this health challenge. Babies are particularly vulnerable to the damaging effects of arsenic that can prevent the healthy development of a babys growth, IQ and immune system to name but a few, said Andy Meharg, lead author of the study and professor of plant and soil sciences at Queens.. Rice has, typically, 10 times more inorganic arsenic than other foods and chronic exposure can cause a range of health problems including developmental problems, heart disease, diabetes and nervous system ...