The Binational Arsenic Exposure Survey (BAsES) was designed to evaluate probable arsenic exposures in selected areas of southern Arizona and northern Mexico, two regions with known elevated levels of arsenic in groundwater reserves. This paper describes the methodology of BAsES and the relationship between estimated arsenic intake from beverages and arsenic output in urine. Households from eight communities were selected for their varying groundwater arsenic concentrations in Arizona, USA and Sonora, Mexico. Adults responded to questionnaires and provided dietary information. A first morning urine void and water from all household drinking sources were collected. Associations between urinary arsenic concentration (total, organic, inorganic) and estimated level of arsenic consumed from water and other beverages were evaluated through crude associations and by random effects models. Median estimated total arsenic intake from beverages among participants from Arizona communities ranged from 1.7 to 14.1 µg
Descrição: Emerging data indicate that rice consumption may lead to potentially harmful arsenic exposure. However, few human data are available, and virtually none exist for vulnerable periods such as pregnancy. Here we document a positive association between rice consumption and urinary arsenic excretion, a biomarker of recent arsenic exposure, in 229 pregnant women. At a 6-mo prenatal visit, we collected a urine sample and 3-d dietary record for water, fish/seafood, and rice. We also tested womens home tap water for arsenic, which we combined with tap water consumption to estimate arsenic exposure through water. Women who reported rice intake (n = 73) consumed a median of 28.3 g/d, which is ∼0.5 cup of cooked rice each day. In general linear models adjusted for age and urinary dilution, both rice consumption (g, dry mass/d) and arsenic exposure through water (μg/d) were significantly associated with natural log-transformed total urinary arsenic (βrice = 0.009, βwater = 0.028, both P < ...
Background In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the risk of arsenic-induced skin lesions appears to differ by sex. Methods We conducted a case-control study in 147 arsenic-exposed Bangladeshi women to assess the association between anemia and arsenic-induced skin lesions. Results We observed that the odds of arsenic-related skin lesions were approximately three times higher among women who were anemic (hemoglobin , 120 g/L) compared to women with normal hemoglobin levels [Odds Ratio (OR) = 3.32, 95 % Confidence Intervals (CI): 1.29, 8.52] after adjusting for arsenic levels in drinking water and other covariates. Furthermore, 75 % of the women with anemia had adequate iron stores (serum ferritin ≥12 μg/L), suggesting that the ...
What is arsenic and where do you find it?. Arsenic is a naturally occurring element that is widely distributed in the earths crust. Arsenic can exist in several oxidation states with other elements as inorganic or organic arsenic. It is a silvery-gray, semimetallic substance that tarnishes in air. Inorganic and organic arsenic compounds are white in color, and have no smell or special taste. Inorganic arsenic occurs naturally in certain types of soils and rock formations. Inorganic arsenic compounds are mainly used as a preservative in pressure-treated wood to make it resistant to rotting and decay. Organic arsenic compounds are used to make insect killers, weed killers, and fungicides.. Who is exposed to arsenic?. Anyone can be exposed to arsenic since low levels of arsenic are present in soil, water, food, and air. People are primarily exposed to arsenic through eating food (fish and shellfish), drinking water, or breathing air containing arsenic. If wells are drilled in areas where naturally ...
To date, we have analyzed 29668 hand tubewell water samples from 1721 villages / wards in 250 GPs/ Municipal area from all 26 blocks of the district (Table I). Figure I shows the groundwater arsenic situation in each block of Murshidabad with Pie-diagram distribution. We observed arsenic concentration above 10 µg/L in 15953 (53.8%) hand tubewells and in 7911 (26.7%) above 50 µg/L and 1337 (4.5%) of the tubewells had arsenic concentrations above 300µg/L. In Murshidabad the number of villagers where we found arsenic concentration above 10, 50 and 300 µg/L are 1320, 971 and 281 respectively; and 25, 24 and 17 blocks were found to be contaminated with arsenic levels above 10, 50 and 300 µg/L. Arsenic level above 1000µg/L was found in 71 tubewells; the maximum arsenic contamination level found in this district is 3003µg/L in the Nawda and Raghunathganj I blocks. ...
TY - CHAP. T1 - Arsenic methylation capability and human health. AU - Hsueh, Yu Mei. AU - Huang, Yung Kai. AU - Chung, Chi Jung. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The metabolism of inorganic arsenic takes place through a series of reactions, including reduction and oxidative methylation reactions. Biomethylation is considered a major detoxification pathway for inorganic arsenic. However, interspecies differences exist according to the efficiency with which inorganic arsenic is metabolized and excreted in urine. Intermediate trivalent methylated arsenic species are more cytotoxic and genotoxic than inorganic compounds. The arsenic methylation profile is influenced by demographic characteristics, lifestyle, diet and genetic susceptibility. Inefficient methylation is related to the risk of cancer and noncancer disease.. AB - The metabolism of inorganic arsenic takes place through a series of reactions, including reduction and oxidative methylation reactions. Biomethylation is considered a major ...
TY - BOOK. T1 - Arsenic Exposure and Health Effects IV. T2 - Arsenic exposure, null genotypes of glutathione s-transferase m1, t1 and p1, and risk of carotid atherosclerosis among residents in the Lanyang Basin of Taiwan. AU - Chappell, W.R.. AU - Abernathy, C.O.. AU - Calderon, R.L.. AU - Chiou, Hung-Yi. AU - Wang, I.H.. AU - Hsueh, Yu-Mei. AU - Chiou, S. T.. AU - Chou, Yi Li. AU - Teh, Hee-Wen. AU - Chen, Chien Jen. PY - 2001. Y1 - 2001. N2 - This collected volume of authoritative articles represents the state-of-the-art in arsenic research. Arsenic experts from around the world, participants in the Fourth International Conference on Arsenic Exposure and Health Effects organized by the Society of Environmental Geochemistry and Health in 2000, present their critical findings.A vital contribution to arsenic study and policy making, this volume examines the global impact of the toxin and discusses arsenic in the environment, mechanisms of arsenic metabolism and carcinogenesis, water treatment ...
To date, we have analyzed 8334 hand tubewell water samples from 1374 villages/Para/wards in 79 GPs/ Municipal area from 17 blocks of this district. Table I shows the distribution of arsenic in tubewell water from South 24 Parganas district. Figure I shows the groundwater arsenic contamination status in 17 blocks of South 24 Parganas with Pie-diagram distribution. Table I shows that arsenic concentration above 10 µg/L in 3500 (42%) hand tubewells and in 2359 (28.3%) above 50 µg/Land 547 (6.6%) had arsenic concentrations above 300µg/L. From the above analysis, it appears that groundwater in 12 block contains arsenic above WHO guideline value of arsenic in drinking water (10 µg/L) and 11 blocks exceeds Indian standard value for As in drinking water (50 µg/L). Arsenic level above 1000µg/L was found in 30 tubewells; the maximum arsenic contamination level found in this district is 3700µg/L in the Baruipur block. In blocks Diamond Harbour, Gosaba, Joynagar II and Thakurpukur all the tubewells ...
Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Global DNA hypomethylation occurs during arsenic-induced malignant transformation in rodent liver cells. DNA hypomethylation can increase gene expression, particularly when occurring in the promoter region CpG sites, and may be a non-genotoxic mechanism of carcinogenesis. Thus, in the present study liver samples of male mice exposed to 0 (control) or 45 p.p.m. arsenic (as NaAsO2) in the drinking water for 48 weeks were analyzed for gene expression and DNA methylation. Chronic arsenic exposure caused hepatic steatosis, a lesion also linked to consumption of methyl-deficient diets. Microarray analysis of liver samples showed arsenic induced aberrant gene expression including steroid-related genes, cytokines, apoptosis-related genes and cell cycle-related genes. In particular, the expression of the estrogen receptor-α (ER-α), and cyclin D1 genes were markedly increased. RT-PCR and ...
Arsenic is carcinogenic, possibly partly through epigenetic mechanisms. We evaluated the effects of arsenic exposure and metabolism on DNA methylation. Arsenic exposure and methylation efficiency in 202 women in the Argentinean Andes were assessed from concentrations of arsenic metabolites in urine (inorgani
The German Federal Institute for Risk Assessment (BfR) is recommending that methods to minimise the levels of inorganic arsenic in rice products should be investigated in the light of recent dietary exposure studies in the German population.. Analyses of rice and rice products in Germany have shown that many contain relatively high concentrations of carcinogenic inorganic arsenic. Some products, such as rice cakes, were found to contain more inorganic arsenic than rice grains, but the reason for this is not known.. The BfR has calculated the intake of toxic inorganic arsenic compounds through the consumption of rice and rice products in Germany and concludes that they could make a significant contribution to the overall intake, especially in children. "Because inorganic arsenic compounds are classified as carcinogenic for humans, foodstuffs should only contain as little as reasonably achievable," says BfR President Professor Dr Dr Andreas Hensel.. The Institute is advising food manufacturers to ...
Posted on Jul 7, 2013 , 1 comment. By The Editors Despite the high toxicity of arsenic, there are arsenical drugs - in other words, there are drugs that contain arsenic. One of these drugs, roxarsone, is used in chicken feeds to kill intestinal parasites, promote growth (make the chicken grow faster) and improve pigmentation (make meat look pinker). Roxarsone contains organic arsenic, which is much less toxic than inorganic arsenic. However, mounting evidence suggests organic arsenic can change into inorganic arsenic once administered to chickens. The U.S. Environmental Protection Agency (EPA) classifies inorganic arsenic as a known human carcinogen - This classification is based on extensive population studies of lung cancers that developed following arsenic exposure through inhalation, and skin cancers that developed following ingestion of contaminated drinking water in adults. According to the EPA, arsenic exposure also may be associated with a higher incidence of bladder, liver, kidney, and ...
Studies into arsenic in food have been restricted by a lack of speciation data. Of more than 100,000 arsenic concentrations submitted to EFSA for evaluation, some 98% were reported as total arsenic but only a few broke figures down into organic and inorganic. European authorities have adopted EFSAs 2009 report and maximum limits for inorganic arsenic are planned to be introduced for rice and rice-based infant food. The introduction of maximum limits for cereals, algae and food supplements is also under discussion.. In the US the Food and Drug Administration has been measuring total arsenic concentrations in food products since 1991, but has yet to establish a specific standard. A guideline for arsenic (total) in crustacean and molluscs of 76ppm and 86 ppm respectively, was introduced in 1993, but it is currently examining the risks associated with longterm exposure.. CODEX has a standard for total arsenic in various foods (fats, margarine, olive oil, vegetable oil, mineral water and salt), but ...
Arsenic contamination takes serious turn in Narail. NARAIL June 12 : Arsenic contamination has taken a serious turn in all the three upazilas of the district in recent times, reports BSS. The number of arsenic affected people is increasing in Narail district day by day. Kalia upazila is a severely arsenic affected area in district. About 85 per cent tube-wells in the area are marked with red paint to warn the people that the waters of these tube-wells are contaminated by arsenic, Md Ahsan Habib, Upazila Nirbahi Officer, Kalia said.. In Kalia upazila the waters of 11,304 tube-wells have been tested, of which contamination of arsenic beyond permissible level has been detected in 8,507 tube- wells.In Lohagora upazila, waters of 1,023 tube-wells have been tested, of which contamination of arsenic has been detected in 696 tube-wells. In Narail Sadar upazila the waters of 1,269 tube-wells have been tested and of which contamination of arsenic has been detected in 499 tube-wells.. At least 55 persons ...
Beyond Pesticides, September 20, 2012) Raising questions about the adequacy of pesticide regulation, historically and ongoing, Consumer Reports published a new study yesterday that finds "worrisome" levels of inorganic arsenic in rice products. Arsenic is a known human carcinogen. This new report follows its earlier one that finds high levels of arsenic in apple and grape juice. The report finds elevated arsenic levels across organic and conventional products, raising serious questions about widespread environmental and soil contamination from past and continuing arsenical pesticide use. Although organic arsenic occurs naturally in the environment, it is synthetic inorganic arsenic that poses the biggest health hazards to humans and animals. So, humans are exposed to two kinds of the carcinogen in air, water, soil, and food sources. But unlike organic arsenic, which is found naturally in the environment, inorganic arsenic is present in our food as a result of pesticide application and animal ...
In June 2011, AdEdge Water Technologies was contacted by Sunrise Engineering to design, manufacture, and start up an arsenic removal system for the Spring Creek Utilities Company located in Elko, Nevada. The existing water system consisted of three wells feeding into a centralized distribution system with a maximum capacity of 1950 GPM and serves a population of 1500 residents. The AdEdge treatment system consists of five WaterPOD containerized units each housing an ADGS+ coagulation/filtration arsenic removal system. All five WaterPODs are integrated with an existing chlorine module to oxidize arsenic (III) to arsenic (V) for optimal removal. The units also integrate with an AdEdge ADIN chemical feed module which injects ferric chloride in the raw water to supplement the iron concentration to aid in arsenic removal. A CO2 pH adjustment module is furnished in each WaterPOD to reduce the pH from 7.89 to a neutral pH of 7. AdEdge also provided an H2Zero backwash recycle system that reclaims 100% ...
Silver Spring, MD (TFC) - An approved animal drug known as 3-Nitro® (roxarsone) was added to chicken feed prior to July 2011. This drug was known to contain an organic form of arsenic, which is known to be toxic, but indeed it is less toxic than inorganic arsenic. In 2011, the Food and Drug Administration admitted that roxarsone contained inorganic arsenic, which is a much more toxic compound. After discovering this, the FDAs Center for Veterinary Medicine and the Center for Food Safety and Applied Nutrition developed a new analytical method used to detect minute levels of arsenic in animal tissue.. It is important to note that organic arsenic is in the environment as a naturally occurring substance and can also be a contaminant in water, air, soil and various food products. In this case, the cause for concern is the organic arsenic found in 3-Nitro® that could transform into inorganic arsenic found in the chicken feed at high levels.. The FDA made a statement in the Product Safety ...
Arsenic biochemistry refers to biochemical processes that can use arsenic or its compounds, such as arsenate. Arsenic is a moderately abundant element in Earths crust, and although many arsenic compounds are often considered highly toxic to most life, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms. This pattern is general for other related elements, including selenium, which can exhibit both beneficial and deleterious effects. Arsenic biochemistry has become topical since many toxic arsenic compounds are found in some aquifers, potentially affecting many millions of people via biochemical processes. The evidence that arsenic may be a beneficial nutrient at trace levels below the background to which living organisms are normally exposed has been reviewed. Some organoarsenic compounds found in nature are arsenobetaine and arsenocholine, both being found in many marine organisms. Some ...
TY - JOUR. T1 - Urinary excretion of arsenic following rice consumption. AU - Meharg, A. A.. AU - Williams, P. N.. AU - Deacon, C. M.. AU - Norton, Gareth John. AU - Hossain, Mohammed Kamal. AU - Louhing, D.. AU - Marwa, Ernest Melkiory. AU - Lawgalwi, Y.. AU - Taggart, Mark Antony. AU - Cascio, Claudia. AU - Haris, P.. PY - 2014/11. Y1 - 2014/11. N2 - Patterns of arsenic excretion were followed in a cohort (n = 6) eating a defined rice diet, 300 g per day d.wt. where arsenic speciation was characterized in cooked rice, following a period of abstinence from rice, and other high arsenic containing foods. A control group who did not consume rice were also monitored. The rice consumed in the study contained inorganic arsenic and dimethylarsinic acid (DMA) at a ratio of 1:1, yet the urine speciation was dominated by DMA (90%). At steady state (rice consumption/urinary excretion) ∼40% of rice derived arsenic was excreted via urine. By monitoring of each urine pass throughout the day it was observed ...
ARSENIC TREATMENT The 1998 European Drinking Water Directive includes an arsenic standard of 10 ?g/l, reduced from 50 ?g/l in the 1980 Directive. Learn more about ARSENIC TREATMENT on GlobalSpec.
Arsenic is found in multiple forms, some of which are more toxic to humans than others. In Alaska, most arsenic in groundwater is likely derived from inorganic arsenic that occurs naturally in the Earths crust, most commonly as the mineral arsenopyrite. When arsenopyrite oxidizes into its elemental components (similar to the way iron rusts) and those components enter the groundwater system, the resulting arsenic, as pentavalent arsenic [As(V) or arsenate] and trivalent arsenic [As(III) or arsenite], is toxic to humans. Arsenite is both more harmful and more mobile in groundwater than arsenate. Soils in some parts of Alaska have high concentrations of inorganic arsenic, which can leach into groundwater and render private well water unsafe for consumption. Arsenic in surface water, however, tends to bind with iron oxide and organic material, making it less mobile, and therefore, less likely to reach drinking water sources. Arsenic also accumulates in food crops grown in arsenic-rich soil or ...
treatment with 400 micrograms a day of folic acid, the U.S. recommended dietary allowance, reduced total blood arsenic levels in the study population by 14 percent..."Folic acid supplementation enhanced the detoxification of arsenic to a form that is more readily excreted in urine," said Mary Gamble...Folic acid increased the methylation or detoxification of arsenic in the body, allowing the body to change some of its more toxic metabolite, or methylarsonic (MMA) acid, to a form that could more easily be excreted from the body, thus lowering the levels of arsenic found in the blood..." ...
2000, describes a method for removing arsenic from fly ash, in which arsenic is recovered as scorodite. The first treatment stage of the arsenic-containing material is the oxidation of trivalent arsenic (As(lll)) into pentavalent arsenic (As(V)) with a gas containing sulphur dioxide and oxygen in oxidising conditions, in which arsenic does not precipitate. After this, arsenic is precipitated in atmospheric conditions, in which the Fe(III)/As(V) mole ratio is specified as 1. Precipitation is carried out either in one or several stages, but precipitation as scorodite demands the over-saturation of the solution, which is achieved by recycling scorodite crystals to the first precipitation reactors and simultaneously neutralising the suspension. A beneficial pH range is around 1-2 and this is maintained by feeding a suitable neutralising agent into the precipitation stage. In these conditions, arsenic can be precipitated to the level of 0.5 g/l. The final arsenic removal to a level below 0.1 mg/l is ...
Millions now suffer the effects of chronic arseniasis related to environmental arsenic exposure. The biological mechanisms responsible for arsenic-induced toxicity and especially chronic effects, including cancer, are not well known. The U.S. Armed Forces Institute of Pathology (AFIP) is participati …
Arsenic (As) is an ubiquitous chemical element that occurs in nature in the form of organic and inorganic compounds, and its harmful effects are well known and described. It is well known that inorganic arsenic (III and V) compounds are more toxic than organic compounds. Also the bioavailability of arsenic from different chemical compounds varies. Organic forms of arsenic, which are most commonly found in fish and seafood, undergo little biotransformation after consumption and are excreted from the body in virtually unchanged form. On the other hand, inorganic arsenic compounds are well absorbed and metabolized. Adverse effects of inorganic arsenic Long-term exposure to arsenic derived from inorganic compounds results in an increased risk of developing various types of cancer, including skin, bladder, lung, kidney, liver and prostate cancer. In addition, exposure to inorganic arsenic is accompanied by disorders of gastrointestinal, cardiovascular, blood, respiratory, neurological, immune, ...
Commonly found arsenic species in human urine are AsIII (arsenite), AsV (arsenate), MMA (monomethyl arsenic acid), DMA (dimethylarsinic acid) and AB (arsenobetaine). Evidence has shown that these species vary in toxicity and have the potential to be used as biomarkers for human exposure. For human exposure assessments in areas that have naturally occurring arsenic contaminated sources, or those who live or work near contaminated environmental sites where arsenic has been used, it is important to fully understand what species of arsenic residents are being exposed to in order to grasp the risk of arsenic exposure. Since it is difficult to determine direct human exposures, a swine model was used as a surrogate. Urine samples from these studies were analyzed using high-performance liquid chromatography and inductively coupled plasma mass spectrometry (LCICPMS) to quantitate arsenic species. There was a range of 64-74% DMA determined in swine urine samples for all test soils where a range of 60-75% ...
Researchers at the Lawrence Berkeley National Laboratory have invented ARUBA (Arsenic Removal Using Bottom Ash) a material that effectively and affordably removes high concentrations of arsenic from contaminated groundwater. The technology is cost-effective because the substrate?bottom ash from coal fired power plants?is a waste material readily available in South Asia. During fieldwork in four sub-districts ofBangladesh, ARUBA reduced groundwater arsenic concentrations as high as 680 ppb to below the Bangladesh standard of 50 ppb. Key results from three trips in Bangladesh and one trip to Cambodia include (1) ARUBA removes more than half of the arsenic from contaminated water within the first five minutes of contact, andcontinues removing arsenic for 2-3 days; (2) ARUBA?s arsenic removal efficiency can be improved through fractionated dosing (adding a given amount of ARUBA in fractions versus all at once); (3) allowing water to first stand for two to three days followed by treatment with ARUBA produced
According to recent reports, millions of people across the globe are suffering from arsenic (As) toxicity. Arsenic is present in different oxidative states in the environment and enters in the food chain through soil and water. In the agricultural field, irrigation with arsenic contaminated water, that is, having a higher level of arsenic contamination on the top soil, which may affects the quality of crop production. The major crop like rice (Oryza sativa L.) requires a considerable amount of water to complete its lifecycle. Rice plants potentially accumulate arsenic, particularly inorganic arsenic (iAs) from the field, in different body parts including grains. Different transporters have been reported in assisting the accumulation of arsenic in plant cells; for example, arsenate (AsV) is absorbed with the help of phosphate transporters, and arsenite (AsIII) through nodulin 26-like intrinsic protein (NIP) by the silicon transport pathway and plasma membrane intrinsic protein aquaporins. Researchers and
Inorganic arsenic is used for hardening copper and lead alloys. It also is used in glass manufacturing as a decolorizing and refining agent, as a component of electrical devices, in the semiconductor industry, and as a catalyst in the production of ethylene oxide. Arsenic compounds are used as a mordant in the textile industry, for preserving hides, as medicinals, pesticides, pigments, and wood preservatives. Approximately 90% of the domestic consumption of arsenic is currently used with production of chromated copper arsenate (CCA), a wood preservative, the production of which is currently being phased out. Arsenic is also found naturally in the environment and is typically present in soil and water at detectable levels. Sources of human exposure to inorganic arsenic include drinking water, diet, air, and soils (which can contain naturally occurring arsenic or contamination from anthropogenic sources). This draft IRIS health assessment addresses only cancer human health effects that may result ...
Downloadable (with restrictions)! We exploit recent molecular genetics evidence on the genetic basis of arsenic excretion and unique information on family links among respondents living in different environments from a large panel survey within a theoretical framework incorporating optimizing behavior to uncover the hidden costs of arsenic poisoning in Bangladesh. We provide for the first time estimates of the effects of the ingestion and retention of inorganic arsenic on direct measures of cognitive and physical capabilities as well as on the schooling attainment, occupational structure, entrepreneurship and incomes of the rural Bangladesh population. We also provide new estimates of the effects of the consumption of foods grown and cooked in arsenic-contaminated water on individual arsenic concentrations. The estimates are based on arsenic biomarkers obtained from a sample of members of rural households in Bangladesh who are participants in a long-term panel survey following respondents and their
The WHO recommended value of arsenic contamination in water is 0.01 mg/l, while the maximum permissible limit for Bangladesh and India has been fixed at 0.05 mg/l. In the DCH-SOES survey, less than 0.01 mg/l arsenic concentration was detected in 46% or 2803 out of 6101 water samples while above the WHO recommended value (0.01 mg/l) was found in the rest 54% or 3298 samples. On the other hand, arsenic concentration at less than the permissible limit (0.05 mg/l) was detected in 62% or 3783 samples, while above the limit was found in the rest 38% or 2318 water samples. Arsenic contamination at higher level than the WHO recommended value was found in the tube-wells of 52 districts out of the 60 surveyed. Of these, the level of arsenic presence exceeds the maximum permissible limit in the tube-wells water of 41 districts. In 11 districts, the level of arsenic concentration was found more than the WHO recommended value, but less than the maximum permissible limit. That means, highest 0.05 mg/l exist ...
In mammals, methylation occurs in the liver by methyltransferases, the products being the (CH3)2AsOH (dimethylarsinous acid) and (CH3)2As(O)OH (dimethylarsinic acid), which have the oxidation states As(III) and As(V), respectively.[2] Although the mechanism of methylation of arsenic in humans has not been elucidated, the source of methyl is methionine, which suggests a role of S-adenosyl methionine.[25] Exposure to toxic doses begin when the livers methylation capacity is exceeded or inhibited. There are two major forms of arsenic that can enter the body, arsenic (III) and arsenic (V).[26] Arsenic (III) enters the cells though aquaporins 7 and 9, which is a type of aquaglyceroporin.[26] Arsenic (V) compounds use phosphate transporters to enter cells.[26] The arsenic (V) can be converted to arsenic (III) by the enzyme purine nucleoside phosphorylase.[26] This is classified as a bioactivation step, as although arsenic (III) is more toxic, it is more readily methylated.[27]. There are two routes ...
The arsenic speciation and arsenic removal in chitosan packed column were studied. Arsenic removal experiments were carried out with an arsenic standard solution (1.0 mg/l) and drilled well water samples from Limon Mine Community at different pH, water flowrate, and volume of adsorbent material. The simulation of arsenic speciation was carried out at a pH range from 0 to 12, a temperature of 25ºC, a pE equal to 4, and a total arsenic concentration of 1.34 x 10-5 mol kg-1. According to speciation calculations arsenic is found mainly in oxidized form in the conditions of Limon Mines drilled well waters, dihydrogen arsenate ion (H2AsO4-), and hydrogen arsenate ion (HAsO42-) being the major species. The experiments showed that arsenic adsorption depends mainly on the pH as well as the activity of functional groups that compose the chitosan structure. At pH 3 and volume of adsorbent material of 337.8 cm3 an adsorption of 94% was obtained from arsenic standard solution, and the arsenic present in ...
Arsenic toxicity is species-dependent for mammals and is transformed to other metabolites in various organs. In order to understand its metabolism, in-vitro simulation experiments were set up for various organ tissues. As(V) was transformed to As(III), while DMA(V) was changed to DMAS in sheep rumen, but the suspected MA-V) was not formed. This is different for the incubation of seaweed in rumen fluid, which points to a different unknown source for MA(V). In another study, dog MDCK kidney cells showed that inorganic arsenicals were methylated in kidney cells while the exposed DMAS was only oxidized to DMA(V) in kidney cells, and the exposed DMA(V) rarely transformed. The toxicities of arsenicals in dog kidney cells is dependant upon the uptake rates and the transformation of arsenicals. DMAS was as toxic as the inorganic arsenic species and an order to magnitude more toxic than the oxo-species. Methylated arsenic species can accumulate in hair and wool and can be used as a biomarker for arsenic ...
Arsenic concentrations in domestic well-water throughout large regions of Minnesota exceed the public drinking-water standard set by the U.S. Environmental Protection Agency. The frequency of arsenic contamination in domestic wells is a serious and widespread public-health concern; long-term exposure to arsenic is toxic to humans, even at extremely low concentrations. Although the Minnesota well code now requires that each new potable water-supply well be tested for arsenic, the information can come only after the well has been drilled. Although homeowners can purchase arsenic-removal systems, they are expensive, require maintenance, and do not provide alarms for high arsenic concentrations or system failure. It would be preferable if wells could be placed where the risk of arsenic contamination of groundwater is known to be low. This article summarizes the authors collaboration with the U.S. Geological Survey, the Minnesota Geological Survey, and the Minnesota Department of Natural Resources to ...
Arsenic contamination takes serious turn in Chandpur. CHANDPUR, June 25: Arsenic contamination has taken a serious turn in Chandpur district recently.. This was disclosed by Md. Sadeq Hossain, Executive Engineer of the local Public Health Engineering Department, in an exclusive talk with this correspondent recently.. About 1.25 lakh shallow tube-wells of all the eight upazilas of the district have already been sealed as the waters of those contain arsenic beyond permissible limits which are very much harmful to human body, he added. He disclosed that on an average 98 per cent shallow tube-wells of the district are arsenic contaminated.. A survey shows that 96 per cent tube-wells in Hajiganj, 98 per cent tube-wells in Faridganj, Shahrasti and Kochua, 85 per cent tube-wells in Haimchar and 80 per cent tube-wells in Matlab Sadar and newly created Matlab North upazilas are arsenic contaminated.. It is officially learnt that at present 5,000 people, mostly old men, women and children have been ...
Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread. While BaP acts by binding to and inducing mutations in critical sites on DNA, the mechanism(s) of arsenic carcinogenesis remains unknown. Data from epidemiological studies of arsenic copper smelter workers and arsenic ingestion in drinking water suggest a positive interaction f
Digging of tube wells to provide drinking water in Bangladesh has had the side-effect of exposing people to arsenic which contaminates groundwater in the country. This project investigates (i) how arsenic concentrations that result from the ingestion of arsenic affect the capabilities and productivity of the rural Bangladesh population and (ii) how changes in food consumption, by affecting arsenic ingestion and excretion, affect arsenic concentrations. ...
Ingestion of arsenic is relatively common in the setting of homicide and is occasionally used in deliberate self-poisoning. Arsine gas and CCA exposure are not uncommon industrial exposures. Most organs can be involved and the diagnosis may not be obvious. \\ \\ Arsenic is a classic poison; implicated in the deaths of Tchaikovsky and Napoleon. It has also been used as a therapeutic substance since ancient times. It has been used in traditional Chinese medicines and most recently as a chemotherapeutic agent for the treatment of acute promyelocytic leukaemia. Chronic arsenic poisoning is a major public health crisis and an environmental disaster in Bangladesh and West Bengal, due to the contamination of ground water that affects millions of people. These chronic problems are beyond the scope of this course. \\ \\ Arsenic exists in many forms: arsine gas, elemental arsenic, inorganic oxides and organic arsenic. Acute arsenic poisoning is rare. The elemental form of arsenic is non-toxic but the ...
Compounds of arsenic were recognized as highly toxic long before arsenic was even recognized as an element in 1649 (by Schroeder, a German pharmacist). Nero used arsenic to poison Britannicus in 55 AD to secure the Roman throne. In 17th century France, white arsenic (As2O3) was known as poudre de succession (inheritance powder). Today, approximately 90 percent of all arsenic used in the US is used as a wood preservative. Arsenic is also used in electronics (gallium arsenide) and continues to be used in agricultural chemicals (pesticides, insecticides, herbicides, algaecides, fungicides and growth stimulants for plants and animals). Arsenic, being an element, is never destroyed once released into the environment. It will be with us forever.. Arsenic consumption is linked to a number of adverse health effects including skin, bladder and lung cancer. Oxygenated compounds of arsenic (arsenates: As+5 and arsenites: As+3) are soluble in water and, when ingested, mimic phosphates in the body. They can ...
Quilicura is a municipality located in the Santiago Metropolitan Region in Chile. Well #3 has a flow of 1600 gallons per minute (100 liters per second). The well has a high concentration of arsenic that fluctuates between 0.040 mg/L and 0.060 mg/L, well above the World Health Organization standard of 0.010 mg/L. In addition to the high arsenic concentration, the site has challenges with pH that ranges from 7.0 to 9.5. AdEdge was contacted by EcoRiles in 2013 to design, manufacture, and commission an arsenic removal solution for the Quilicura municipalty.The AdEdge arsenic treatment solution consists of four WaterPOD containerized systems rated for a combined total of 1600 gpm (100 lps). Each WaterPOD contains six 48-inch carbon steel vessels in a parallel configuration. The vessels are loaded with AdEdge Bayoxide E33 granular ferric oxide media. The E33 binds the arsenic to the media structure and does not lose that bond during backwash. The system has an ADIN chemical feed dosing system that is ...
Arsenic Removal During Iron Removal. Darren A. Lytle U.S. Environmental Protection Agency ORD, NRMRL, WSWRD, TTEB, Cincinnati, Ohio 45268 [email protected] Arsenic Rule Webcast October 20, 2004. Iron-Based Arsenic Removal Processes. Slideshow 4256770 by luigi
BACKGROUND A large population in West Bengal, India has been exposed to naturally occurring inorganic arsenic through their drinking water. A cross-sectional survey involving 7683 participants of all ages was conducted in an arsenic-affected region between April 1995 and March 1996. The main focus of the study was skin keratoses and pigmentation alterations, two characteristic signs of ingested inorganic arsenic. Strong exposure-response gradients were found for these skin lesions. The study also collected limited information concerning respiratory system signs and symptoms, which we report here because increasing evidence suggests that arsenic ingestion also causes pulmonary effects. METHODS Participants were clinically examined and interviewed, and the arsenic content in their current primary drinking water source was measured. There were few smokers and analyses were confined to non-smokers (N = 6864 participants). RESULTS Among both males and females, the prevalence of cough, shortness of breath
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1. Total arsenic The method described in this manual assesses arsenic exposure by analyzing urine through the use of inductively coupled-plasma dynamic reaction cell-mass spectrometry (ICP-DRC-MS). Urine is analyzed because urinary excretion is the major pathway for eliminating arsenic from the mammalian body. This method achieves rapid and accurate quantification of total urinary arsenic. Total urine arsenic concentrations are determined by using ICP-DRC- MS. This multielement analytical technique is based on quadrupole ICP-MS technology and includes DRC™ technology, which minimizes or eliminates much argon-based polyatomic interference. Coupling radio frequency power into a flowing argon stream seeded with electrons creates the plasma, the heat source, which is ionized gas suspended in a magnetic field. Predominant species in the plasma are positive argon ions and electrons. Diluted urine samples are converted into an aerosol by using a nebulizer inserted within a spray chamber. A portion of ...
Exposure to arsenic, a common environmental toxin found in drinking water, leads to a host of neurological pathologies. We have previously demonstrated that developmental exposure to a low level of arsenic (50ppb) alters epigenetic processes that underlie deficits in adult hippocampal neurogenesis leading to aberrant behavior. It is unclear if arsenic impacts the programming and regulation of embryonic neurogenesis during development when exposure occurs. The master negative regulator of neural-lineage, REST/NRSF, controls the precise timing of fate specification and differentiation of neural stem cells (NSCs). Early in development (embryonic day 14), we observed increased expression of Rest, its co-repressor, CoREST, and the inhibitory RNA binding/splicing protein, Ptbp1, and altered expression of mRNA spliced isoforms of Pbx1 that are directly regulated by these factors in the male brain in response to prenatal 50ppb arsenic exposure. These increases were concurrent with decreased expression of
This blood test is used to measure Arsenic levels. Arsenic is a common cause of acute poisoning through heavy metals. Arsenic enters the environment through the smelting of copper, zinc and lead and is released through the manufacturing of certain chemicals. Pesticides that contain arsenic, when manufactured, release arsine gas. Arsenic has been found in water supplies around the world, which has the potential to leach into seafood. Arsenic is found in rat poisoning, fungicides and products used to protect wood. Arsenic toxicity affects the blood, kidneys, skin, digestive tract and central nervous system ...
Arsenic is a highly poisonous metallic element in the nitrogen family of group Va in the periodic table. Symbol As; aomic number 33; atomic mass 74.9216; melting point ca 817°C; sublimation point ca 613°C; specific gravity 6.80 or 7.004; 5.73; valence -3, 0, +3, or +5.; electronic config. [Ar]3d104s24p3. It appears in three allotropic forms, yellow, black, and gray. The stable form is a brittle, steel-gray hexagonal solid that oxidizes rapidly in air, and at high temperatures burns to form a white cloud of arsenic trioxide. Arsenic and some arsenic compounds sublime when heated and convert to gaseous form. Arsenic is an omnipresent element as arsenic minerals in the various lithosphere or fossil fuels including realgar, orpiment, and arsenopyrite. It is prepared commercially from arsenical pyrites (sulfide ores) by condensation of sublimed gas and by the reduction of white arsenic with carbon. This element contributes hardness and is used in preparing alloys for hard and corrosion-resistant ...
The authors estimated the global burden of disease for bladder, lung, and skin cancers attributable to inorganic arsenic in food. The authors - 1) established dose response estimates by converting dose response estimates for water exposure to human dose; 2) estimated exposure using data on a common range of arsenic content for food crops grown in different parts of the world and dietary patterns in different parts of the world; 3) multiplied the dose-response slope factor with the estimated range of daily dietary inorganic arsenic exposure to characterize cancer risk; and 4) summed across different populations to estimate the global burden of a particular arsenic-induced cancer ...
Protection against arsenic damage in organisms positioned deep in the tree of life points to early evolutionary sensitization. Here, marine sedimentary records reveal a Proterozoic arsenic concentration patterned to glacial-interglacial ages. The low glacial and high interglacial sedimentary arsenic concentrations, suggest deteriorating habitable marine conditions may have coincided with atmospheric oxygen decline after ~2.1 billion years ago. A similar intensification of near continental margin sedimentary arsenic levels after the Cryogenian glaciations is also associated with amplified continental weathering. However, interpreted atmospheric oxygen increase at this time, suggests that the marine biosphere had widely adapted to the reorganization of global marine elemental cycles by glaciations. Such a glacially induced biogeochemical bridge would have produced physiologically robust communities that enabled increased oxygenation of the ocean-atmosphere system and the radiation of the complex ...