Booktopia has Cardiac Arrhythmias 2003, Proceedings of the 8th International Workshop on Cardiac Arrhythmias by Antonio Raviele. Buy a discounted Hardcover of Cardiac Arrhythmias 2003 online from Australias leading online bookstore.
About 20 years ago, the first traditional cardiac EP devices were designed and they were meant for treating less complex arrhythmias. As it became more and more obvious that there is an actual need for a device that can read more complex arrhythmias, savvy businessman Ken Londoner decided to invest in developing a system that can treat atrial fibrillation and ventricular tachyarrhythmia, and thus help millions of people. Today, not only have they developed a device that is able to read more complex arrhythmias, but have also found a way to get rid of the non-biological noise. ...
Defibrillation is a treatment for life-threatening cardiac dysrhythmias, specifically ventricular fibrillation (VF) and non-perfusing ventricular tachycardia (VT). A defibrillator delivers a dose of electric current (often called a countershock) to the heart. This depolarizes a large amount of the heart muscle, ending the dysrhythmia. Subsequently, the bodys natural pacemaker in the sinoatrial node of the heart is able to re-establish normal sinus rhythm. In contrast to defibrillation, synchronized electrical cardioversion is an electrical shock delivered in synchrony to the cardiac cycle. Although the person may still be critically ill, cardioversion normally aims to end poorly perfusing cardiac dysrhythmias, such as supraventricular tachycardia. Defibrillators can be external, transvenous, or implanted (implantable cardioverter-defibrillator), depending on the type of device used or needed. Some external units, known as automated external defibrillators (AEDs), automate the diagnosis of ...
The AVID Study was a multicenter, randomized comparison of antiarrhythmic drug treatment (mostly amiodarone) and ICD implantation to manage patients resuscitated from life-threatening ventricular arrhythmias not due to transient or reversible causes. Eligible arrhythmias included 1) VF; 2) sustained ventricular tachycardia (VT) with syncope; and 3) sustained VT with an ejection fraction of ≤0.40, and symptoms suggestive of severe hemodynamic compromise. The trial design and primary end-point paper have been published (19,20). It is interesting to note that the location of index ventricular arrhythmia presentation was not a factor in eligibility for randomization. Each participating institution had approval from its Institutional Review Board for conduct of the study. All patients who underwent randomization gave written informed consent.. As part of the study design, a registry was maintained of all patients with sustained ventricular arrhythmias at each study site. It included not only ...
Arrhythmias that originate in the ventricular myocardium or His-Purkinje system include premature ventricular beats, ventricular tachycardias that can be sustained or nonsustained, and ventricular fibrillation. Arrhythmia may emerge from a focus of myocardial or Purkinje cells capable of automaticity, or triggered automaticity, or from reentry through areas of scar or a diseased Purkinje system. Ventricular arrhythmias are often associated with structural heart disease and are an important cause of sudden death (Chap. 327). They also occur in some structurally normal hearts, in which case they are usually benign. Evaluation and management are guided by the risk of arrhythmic death, which is assessed based on symptoms, type of arrhythmia, and associated underlying heart disease. ...
Many cerebral strokes are due to undetected cardiac arrhythmias. Any rapid cardiac arrhythmia may induce neurological symptoms as hemiplegia, aphasia, or psychosis. Twenty-eight patients who developed neurological disturbances following various cardiac arrhythmias were carefully studied. Most of these were due to rapid atrial fibrillation or supraventricular tachycardia. Undetected bradycardia due to vagotonia was a common cause of transient episodes of unconsciousness.. The cerebral blood flow was measured in animals when cardiac arrhythmias were induced. It was noted that frequent premature systoles reduced the cerebral blood flow 7 to 12%. More frequent runs of premature systoles caused a greater reduction. Supraventricular ...
A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and on ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated with enalapril (10 mg/kg) daily for 11 months and compared with 26 untreated control rats. Systolic arterial pressure was significantly decreased in treated rats, and at the end of the experiment, it was 199 +/- 3 mm Hg (treated) versus 237 +/- 3 mm Hg (controls) (p less than 0.001). At this time, spontaneous arrhythmias and induced arrhythmias either by programmed electrical stimulation (train of stimuli +1 or 2 extrastimuli) or by trains of eight stimuli at decreasing coupling intervals were observed in isolated heart preparations. Comparing enalapril-treated and control rats, spontaneous arrhythmias (9 of 27 versus 20 of 26, respectively; p less than 0.01), programmed stimulation-induced arrhythmias (3 of 26 versus 12 of 23, respectively; p less than 0.01), and trains of stimuli-induced arrhythmias (4 of 26 versus ...
Background-Genetic predisposition to life-threatening cardiac arrhythmias such as in congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden cardiac death in young adults and children. Recently, mutations in calmodulin (CALM1, CALM2) have been associated with severe forms of LQTS and CPVT, with life-threatening arrhythmias occurring very early in life. Additional mutation-positive cases are needed to discern genotype-phenotype correlations associated with calmodulin mutations. Methods and Results-We employed conventional and next-generation sequencing approaches including exome analysis in genotype-negative LQTS probands. We identified five novel de novo missense mutations in CALM2 in three subjects with LQTS (p.N98S, p.N98I, p.D134H) and two subjects with clinical features of both LQTS and CPVT (p.D132E, p.Q136P). Age of onset of major symptoms (syncope or cardiac arrest) ranged from 1-9 years. Three of five ...
Objectives Our previous study shows that Microvolt T-wave alternans (MTWA) testing has significant value for the prediction of mortality or severe arrhythmic events in a population of individuals with implanted ICDs. Whether MTWA is an accurate predictor of ventricular tachyarrhythmic events in patients without ICDs remains unclear. We conducted a meta-analysis of the predictive value of MTWA testing for mortality and severe arrhythmic events in patients with cardiac dysfunction but without implanted ICDs.. ...
Clinical CharacteristicsThe Students t-test was used to compare the age, sex, height and weight, and initial blood pressure, heart rate, respiratory rate,
Cardiac arrhythmias are becoming one of the major health care problem in the world, causing numerous serious disease conditions including stroke and sudden cardiac death. Furthermore, cardiac arrhythmias are intimately related to the signaling ability of cardiac cells, and are caused by signaling defects. Consequently, modeling the electrical activity of the heart, and the complex signaling models that subtend dangerous arrhythmias such as tachycardia and fibrillation, necessitates a quantitative model of action potential (AP) propagation. Yet, many electrophysiological models, which accurately reproduce dynamical characteristic of the action potential in cells, have been introduced. However, these models are very complex and are very time consuming computationally. Consequently, a large amount of research is consecrated to design models with less computational complexity. This paper is presenting a new model for analyzing the propagation of ionic concentrations and electrical potential in space and
TY - JOUR. T1 - Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia. AU - Weng, Ching Hui. AU - Chung, Fa Po. AU - Chen, Yao Chang. AU - Lin, Shien Fong. AU - Huang, Po Hsun. AU - Kuo, Terry B J. AU - Hsu, Wei Hsuan. AU - Su, Cheng Wen. AU - Sung, Yen Ling. AU - Lin, Yenn Jiang. AU - Chang, Shih Lin. AU - Chou, Li Wei. AU - Yeh, Hung I.. AU - Chen, Yi-Jen. AU - Hong, Yi Ren. AU - Chen, Shih Ann. AU - Hu, Yu Feng. PY - 2016/12/14. Y1 - 2016/12/14. N2 - Observational studies have established a strong association between matrix metalloproteinase-9 (MMP-9) and ventricular arrhythmia. However, whether MMP-9 has a causal link to ventricular arrhythmia, as well as the underlying mechanism, remains unclear. Here, we investigated the mechanistic involvement of myocardial MMP-9 in the pathophysiology of ventricular arrhythmia. Increased levels of myocardial MMP-9 are linked to ventricular arrhythmia attacks after angiotensin II (Ang II) treatment. MMP-9-deficient mice were ...
Abstract: Recently, arrhythmogenic condition has attracted special attention of scientists in the field of different disciplines because sudden cardiac death is often caused by cardiac arrhythmia. Arrhythmias can have different underlying causes. But the underlying mechanism of arrhythmia is not fully understood due to cardiac complexity. As is well known, one particular group of arrhythmias is often associated with the afterdepolarizations. So far, afterdepolarizations have been studied mainly in isolated cardiac cells. The question how the afterdepolarization is produced at a tissue level has not been widely studied yet. In this paper, we use the model of human heart to study how spiral wave or other wave patterns induces the afterdepolarizations in two-dimensional myocardial tissue. We try to obtain the instantaneous spatial distribution of afterdepolarizations by changing the L-type calcium and fast potassium conductance. In order to avoid bringing in afterdepolarizations, the applied ...
Causes of Arrhythmias (Heart Rhythm Disturbances) can depend on each individual situation. Learn about causes of Arrhythmias (Heart Rhythm Disturbances) and find symptoms, diagnosis, and many types of smart treatments for Arrhythmias (Heart Rhythm Disturbances) at FoundHealth.
Sudden cardiac death (SCD) is responsible for 300,000-450,000 deaths per year in the United States. While it is well known that patients with both ischemic and non-ischemic cardiomyopathy (ICM, NICM) are at increased risk for SCD, there is little beyond ejection fraction which has proven useful as a noninvasive predictor to risk stratify these patients.. Myocardial scar has been validated as an arrhythmic substrate in ischemic populations; the majority of successful ablations for lethal ventricular arrhythmias are performed on tissues in peri-infarct regions. Scar provides an anatomic electrical boundary where peri-infarct zones may lead to areas of slow conduction due to the disruption of inter-myocyte electrical conduction.. Myocardial scar is a less organized collagen deposition which disrupts the typical cardiac extracellular matrix. The collagen matrix provides mechanical support to the myocardium dictating ventricular shape, size and stiffness. While typically relatively dormant, the ...
Sudden cardiac death (SCD) is responsible for 300,000-450,000 deaths per year in the United States. While it is well known that patients with both ischemic and non-ischemic cardiomyopathy (ICM, NICM) are at increased risk for SCD, there is little beyond ejection fraction which has proven useful as a noninvasive predictor to risk stratify these patients.. Myocardial scar has been validated as an arrhythmic substrate in ischemic populations; the majority of successful ablations for lethal ventricular arrhythmias are performed on tissues in peri-infarct regions. Scar provides an anatomic electrical boundary where peri-infarct zones may lead to areas of slow conduction due to the disruption of inter-myocyte electrical conduction.. Myocardial scar is a less organized collagen deposition which disrupts the typical cardiac extracellular matrix. The collagen matrix provides mechanical support to the myocardium dictating ventricular shape, size and stiffness. While typically relatively dormant, the ...
Sudden cardiac arrest (SCA) from ventricular arrhythmias affects over 400,000 individuals/year in the U.S. alone and has a dismal survival rate (1). Although reduced left ventricular systolic function (i.e., left ventricular ejection fraction) (2) and symptomatic heart failure (i.e., congestive heart failure) (3) are the major predictors of risk for SCA, they are more sensitive than they are specific. Thus, their primacy in guidelines for implantable cardioverter-defibrillators (ICDs) might lead to potentially unnecessary implantations (1). This motivates the identification of markers for the pathophysiology of ventricular arrhythmias that can improve indices for ICD insertion.. Several candidates exist. Inducing sustained ventricular arrhythmias at electrophysiologic study (EPS) was historically the gold standard but has become tarnished of late. Certainly, SCA is more frequent in ischemic cardiomyopathy patients with positive EPS, yet those with negative EPS still have a substantial arrhythmic ...
Arrhythmia. National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/arrhythmia. Accessed January 4, 2019.. Atrial fibrillation. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115288/Atrial-fibrillation. Updated August 22, 2018. Accessed January 4, 2019.. Atrial flutter. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115251/Atrial-flutter. Updated February 22, 2017. Accessed January 4, 2019.. Atrioventricular (AV) conduction disorders. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T907302/Atrioventricular-AV-conduction-disorders. Updated November 27, 2017. Accessed January 4, 2019.. Understanding your risk for arrhythmia. American Heart Association website. Available at: https://www.heart.org/en/health-topics/arrhythmia/understand-your-risk-for-arrhythmia. Accessed January 4, 2019.. Ventricular arrhythmias. EBSCO DynaMed Plus website. Available ...
Diagnosing arrhythmia can be quite difficult because the medical condition may sometimes produce few symptoms. Many physicians diagnose an arrhythmia by examining the patients medical and family history and by performing physical examinations. To diagnose an arrhythmia, physicians usually ask patients to describe their symptoms. A physician may ask the patient if he or she feels thumping in his or her chest and whether the patient feels dizzy or lightheaded. A physician may also diagnose an arrhythmia by asking a patient if his or her family has a history of arrhythmia or other heart diseases. The doctor may ask the patient if he or she is under medications including over the counter medicines and supplements. A physical exam can also serve as an important diagnostic procedure for arrhythmia. During the physical exam, the doctor will examine the patients heart rate and rhythm, and the pulse to see if they are regular. He or she will also check for swelling in the legs or swelling in the feet, ...
Radiofreqeuncy Ablation therapy for arrhythmias caused by myocardial scar. Ablation Therapy for Arrhythmias and Cardiac Arrhythmias. Read about Ablation Therapy for Arrhythmias
Define Arrhythmias. Arrhythmias synonyms, Arrhythmias pronunciation, Arrhythmias translation, English dictionary definition of Arrhythmias. n. 1. An irregularity in the force or rhythm of the heartbeat: a fatal arrhythmia. 2. A condition characterized by such irregularities: treatments for...
Thank you for your interest in spreading the word on Circulation.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
Ing Cardiac arrhythmia (mayayaus mu rin dysrhythmia) metung yang kataya kareng maragul at metung a lupang lupung a kabilyan nung nu atin epangkaraniwan ing kuryenting pangimut ning pusu. Ing pitig ning pusu malyaring mabilis ya o mabagal at neng misan ustu ya neng misan ali ya. Deng aliwang arrhythmias maliaring ikakamate dala at dapat idala da la keng medical emergencies at maliaring mikacardiac arrest la ampong biglaan ing pangamate da. Deng aliwa bala ra makabuysit mung symptomas. Deng aliwa naman makataid keng amanang at makamatengstroke o embolus. Deng aliwang arrhythmias maina la mu pinduan at maliari lang sabian a normal la. Ing tutu,deng aliwang tau panamdaman dang neng misan ing karelang pusu luksa ya keng kayang pitig, o neng misan naman mika masikan yang pitig nung nu dapat e dinan pagkabalisa.[1]. Ing katayang sinus arrhythmia daleraya ya keng pangkaraniwan a melayari nung nu bagyabagya ing pusu sinikad yang pasikan ampong pamangaina patse mangisnawang palub ampong palual. Keraklan ...
10.1055/b-0035-121513 18 Cardiac Arrhythmias 18.1 Antiarrhythmic Drugs 18.1.1 Basics Antiarrhythmic drugs play a central role in the treatment of cardiac arrhythmias in childhood. But their use must be weighed critically. There are numerous studies in adults showing that class I antiarrhythmic drugs do not reduce mortality, but even increase it in patients with ventricular tachycardia…
Looking for atrial arrhythmia? Find out information about atrial arrhythmia. disturbance in the rate or rhythm of the heartbeat. Various arrhythmias can be symptoms of serious heart heart, muscular organ that pumps blood to all parts... Explanation of atrial arrhythmia
Our data suggest that global and regional arrhythmia substrates change throughout different phases of resuscitation, and that temperature alters substrates differently throughout the phases of resuscitation. At normal temperatures, LAD occlusion increases VEBs, global DOR, and cardiac alternans. TH decreases VEBs, yet increases global DOR, and similarly promotes cardiac alternans. During this phase, temperature does not alter the end result of increased incidence of VT/VF. After ROSC from VF arrest, but still during LAD occlusion, there remains an increase in VEBs and cardiac alternans in CT, whereas global DOR returns to baseline. TH reduces VEBs, the increase in global DOR is no longer seen, and cardiac alternans is similarly increased. Again, the incidence of VT/VF is similarly increased in CT and TH. During LAD reperfusion, the incidence of VEBs and alternans in the CT group is greater than baseline, but global DOR returns to near baseline levels. TH markedly increases the magnitude of ...
Arrhythmia occurs when the hearts rhythm becomes disturbed or arrhythmic. The most common form of arrhythmia is a heart palpitation, known as sinus arrhythmia. More serious forms of heart arrhythmia include atrial fibrillation, ventricular tachycardia and ventricular fibrillation. Arrhythmia requires medical treatment; some rhythm disturbances are addressed through the use of medications, defibrillation, or a pacemaker. Natural options for heart support include fish oil, hawthorn, vitamin C and magnesium.
MedWorm- Cardiac Arrhythmia comments, Description: MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Cardiac Arrhythmia, ID: 284341, By: Feedage Forager
12-lead electrocardiogram is a vital component of electrophysiology workup for symptomatic palpitations and organic cardiac arrhythmias including supraventricular and ventricular arrhythmias.
This rare disease is characterized by episodic weakness, cardiac arrhythmias, and dysmorphic features (short stature, scoliosis, clinodactyly, hypertelorism, small or prominent low-set ears, micrognathia, and broad forehead). The cardiac arrhythmias are potentially serious and life threatening. They include long QT, ventricular ectopy, bidirectional ventricular arrhythmias, and tachycardia. For many years, the classification of this disorder was uncertain because episodes of weakness are associated with elevated, normal, or reduced levels of potassium during an attack. In addition, the potassium levels differ among kindreds but are consistent within a family. Inheritance is autosomal dominant, with incomplete penetrance and variable expressivity. The disease is caused by mutations of the inwardly rectifying potassium channel (Kir 2.1) gene that heighten muscle cell excitability. The treatment is similar to that for other forms of periodic paralysis and must include cardiac monitoring. The ...
This course covers cardiac electrical activity and the interpretation of electrocardiograms. The student echocardiographer develops skill in recognizing normal sinus rhythm versus atypical cardiac rhythms. Students learn to interpret common cardiac dysrhythmias, including sinus, atrial, junctional, and ventricular, and integrate this skill into the daily practice of echocardiography. The students will know the stress echo lab procedures including monitoring the patient. Students will learn to perform auscultation of the heart and lungs. Prerequisite: Acceptance into program, completion of DUTEC 155.. View details for DUTEC 200 ...
This course covers cardiac electrical activity and the interpretation of electrocardiograms. The student echocardiographer develops skill in recognizing normal sinus rhythm versus atypical cardiac rhythms. Students learn to interpret common cardiac dysrhythmias, including sinus, atrial, junctional, and ventricular, and integrate this skill into the daily practice of echocardiography. The students will know the stress echo lab procedures including monitoring the patient. Students will learn to perform auscultation of the heart and lungs. Prerequisite: Acceptance into program, completion of DUTEC 155.. View details for DUTEC 200 ...
Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
An arrhythmia is a change in the rhythm of your heartbeat. When the heart beats too fast, its called tachycardia. When it beats too slow, its called bradycardia. An arrhythmia can also mean that your heart beats irregularly (skips a beat or has an extra beat). At some time or another, most people have felt their heart race or skip a beat.. Minor arrhythmias may be caused by excessive alcohol use, smoking, caffeine, stress or exercise. They usually are not a cause for alarm. Arrhythmias that occur more often or cause symptoms may be more serious and need to be discussed with your doctor.. ...
Cardiac arrhythmia is any of a large and heterogeneous group of conditions in which there is abnormal electrical activity in the heart. The heart beat may be too fast or too slow, and may be regular or irregular. A heart beat that is too fast is called tachycardia and a heart beat that is too slow is called bradycardia. Although many arrhythmias are not life-threatening, some can cause cardiac arrest. ...
ARVC is a hereditary heart condition in which the heart muscle (particularly the right ventricle) is partly replaced by fatty tissue and connective tissue. Cardiac arrhythmias can occur as a result of the changes in the heart muscle. Severe arrhythmias can cause dizziness or even lead to fainting or an acute cardiac arrest (= sudden death). ARVC is a progressive disease that usually presents during the teenage years.. Known mutations in desmosomal proteins ...
Learn more about Surgical Procedures for Arrhythmias (Heart Rhythm Disturbances) at Memorial Hospital Main Page Types of Arrhythmias ...
Learn more about Other Treatments for Arrhythmias (Heart Rhythm Disturbances) at Reston Hospital Center Main Page Types of Arrhythmias ...
Learn more about Type of Arrhythmias (Heart Rhythm Disturbances) at Portsmouth Regional Hospital Main Page Types of Arrhythmias Cause ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at Doctors Hospital of Augusta Main Page Types of Arrhythmias ...
Learn more about Treatments for Arrhythmias (Heart Rhythm Disturbances) at Doctors Hospital of Augusta Main Page Types of Arrhythmias ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at Portsmouth Regional Hospital Main Page Types of Arrhythmias ...
Thanks to everyone who joined us Tuesday, February 24 for the live online chat entitled "Irregular Heart Beat: Is it normal?," hosted by Emory Arrhythmia Center physician Michael Hoskins, MD.. Because arrhythmias are common in young- and middle-aged adults, it is important to understand the symptoms. Some arrhythmias are relatively harmless, but others can be fatal if not treated. Dr. Hoskins provided answers to questions about the diagnosis and treatment of heart rhythm disorders, as well as tips of how to deal with an episode of irregular heart beats. Check out the conversation by viewing the chat transcript! Here are just a few highlights from the chat:. Question: I have observed that during some of these episodes my blood pressure is really low and it has been recognized that sometimes my oxygen level is low during the night. could this be causing my arrhythmias? I do have trouble breathing through a deviated nostril.. ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at St. Davids HealthCare Main Page Types of Arrhythmias ...
Learn more about Type of Arrhythmias (Heart Rhythm Disturbances) at Coliseum Health System Main Page Types of Arrhythmias Cause ...
ABSTRACT: Patients with severe heart failure are at high risk of sudden cardiac death. In the majority of these patients, sudden cardiac death is thought to be due to ventricular tachyarrhythmias. Alterations of the electric properties of single myocytes in heart failure may favor the occurrence of ventricular arrhythmias in these patients by inducing early or delayed afterdepolarizations. Mathematical models of the cellular action potential and its underlying ionic currents could help to elucidate possible arrhythmogenic mechanisms on a cellular level. In the present study, selected ionic currents based on human data are incorporated into a model of the ventricular action potential for the purpose of studying the cellular electrophysiological consequences of heart failure. Ionic currents that are not yet sufficiently characterized in human ventricular myocytes are adopted from the action potential model developed by Luo and Rudy (LR model). The main results obtained from this model are as ...
KCNQ1 has been associated with Long QT Syndrome (LQTS), a life-threatening cardiac arrhythmia syndrome and leading cause of sudden death.
超聲心動圖經常用於評估心律不整,儘管它不記錄心臟的電流活動。超聲檢查探討心臟肌肉和心臟瓣膜的功能;如有異常,嚴重及有危險性的心律不整的機率就高得多。. Electrophysiology study (EPS) is used to assess serious arrhythmias. It is an invasive procedure that involves the passing of thin flexible electrodes through the groin veins and arteries to the heart, in order to record the hearts electrical signals. The wires can also stimulate and trigger an arrhythmia, in order to make the correct diagnosis. Catheter radiofrequency ablation may be performed during EPS, if it has been determined that the patients specific arrhythmia can be treated by delivering a special energy through the ablation catheter and destroying small areas of heart tissue responsible for the arrhythmia ...