TY - JOUR. T1 - Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. AU - Wenzel, Volker. AU - Kern, Karl B. AU - Hilwig, Ronald W.. AU - Berg, Robert A.. AU - Schwarzacher, Severin. AU - Butman, Samuel M.. AU - Lindner, Karl H.. AU - Ewy, Gordon A.. PY - 2005/2. Y1 - 2005/2. N2 - Although arginine vasopressin (AVP) has been shown to be a promising drug during cardiopulmonary resuscitation (CPR), concern has been raised about the potential for AVP-mediated vasoconstriction of the coronary arteries. In a prospective, randomized laboratory investigation employing an established porcine model, the effects of AVP on haemodynamic variables, left anterior descending (LAD) coronary artery cross sectional area employing intravascular ultrasound (IVUS), and return of spontaneous circulation were studied. During sinus rhythm, the LAD coronary artery cross sectional area was measured by IVUS at baseline, and 90 s and 5 min after AVP ...
Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral oxygenation during shoulder surgery in the beach chair position: a prospective, single-blind study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Aim: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight. Methods: We measured fasting blood concentrations of copeptin and glucagon in 102 healthy obese men (mean ± sd age 49.4 ± 10.2 years) and a control group 27 healthy men of normal weight (mean ± sd age 51.5 ± 8.4 years). Differences between groups were evaluated using t-tests, and multiple linear regression analysis, adjusting for age and weight status (normal weight vs obese), was used to calculate unstandardized regression coefficients (β) with 95% CIs between copeptin and glucagon. Copeptin was (natural) log-transformed. Results: The obese men had higher [median (interquartile range)] plasma copeptin concentrations [6.6 (4.6-9.5) vs 4.9 (3.5-6.8) pmol/l; P = 0.040] and higher mean ± sd plasma glucagon concentrations (8.5 ± 3.8 vs 5.3 ± 1.4 pmol/l; P , 0.001) than the ...
Synonyms for arginine vasopressin hormone in Free Thesaurus. Antonyms for arginine vasopressin hormone. 3 synonyms for antidiuretic hormone: ADH, Pitressin, vasopressin. What are synonyms for arginine vasopressin hormone?
Animals were randomly allocated to four groups. In addition to a control group submitted to anaphylactic shock without any added therapy, three groups were designed according to the drug used for resuscitation: epinephrine (Aguettant, Lyon, France) only, AVP (Aguettant) only, and epinephrine followed by AVP (fig. 1). The investigator was not blinded to the drug used. The first bolus of epinephrine or AVP was injected 5 min after shock induction (T0 + 5 min). The second bolus of epinephrine was injected when the MAP began to decrease again after the initial increase following the first bolus. Doses of bolus were chosen according to our previous work.12 Two bolus of AVP followed by a continuous infusion induced the death of the animals due to multiple organs infarction (data not shown). Therefore, only one bolus of AVP was injected. To avoid any excessive volume loading, both drugs were prepared at different dilutions (in saline solution), and the syringes were changed when necessary to preserve a ...
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A New Synthetic Route to YM087, an Arginine Vasopressin Antagonist.|span||/span| | Takashi Tsunoda; Akihiro Tanaka; Toshiyasu Mase; Shuichi Sakamoto | download | BookSC. Download books for free. Find books
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Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin Academic Article ...
The antidiuretic hormone arginine vasopressin (AVP) receptors are G protein-coupled receptors which consists of at least three types: V1A (vascular/hepatic) and V1B (anterior pituitary) receptors, which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+; and V2 (kidney) re...
We studied the involvement of periventricular and hypothalamic angiotensinergic and cholinergic pathways in osmotically induced arginine vasopressin (AVP) release into the blood. In conscious Wistar rats, i.c.v. injections of 0.2, 0.3 and 0.6 M hyperosmolar saline (5 μl) resulted in concentration-dependent increases in AVP release (5.2 ± 1.5, 10.6 ± 2.2 and 18.0 ± 2.2 pg/ml, respectively, vs. 2.0 ± 0.1 in controls). The two lower saline concentrations did not affect arterial blood pressure (non-pressure-associated AVP release), whereas 0.6 M saline induced increase in blood pressure (pressure-associated AVP release). In the first set of experiments, periventricular angiotensin AT1, muscarinic or nicotinic receptors were blocked by i.c.v. administration of losartan (10 nmol), atropine (100 nmol) or hexamethonium (100 nmol), respectively, before i.c.v. hyperosmolar saline injections. Losartan significantly reduced the 0.2 M and 0.3 M, but not the 0.6 M, saline-induced increase in AVP release. ...
3,4-methylenedioxymethamphetamine (MDMA) and its derivatives, 2,5-dimethoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine (PMA) are recreational drugs whose pharmacological effects have recently been attributed to serotonin 5HT2A/C receptors. However, there is growing evidence that the oxytocin/vasopressin system can modulate some the effects of MDMA. In this study, MDMA (2.5-10 mg/kg), DOB (0.5 mg/kg) or PMA (0.005, 0.1 or 0.25 mg/kg) were administered intramuscularly (IM) to adult zebrafish, alone or in combination with the V1a vasopressin antagonist, SR49059 (0.01-1 ng/kg), before carrying out conditioned place preference (CPP), social preference, novel tank diving and light-dark tests in order to evaluate subsequent rewarding, social and emotional-like behaviour. The combination of SR49059 and each drug progressively blocked: 1) rewarding behaviour as measured by CPP in terms of time spent in drug-paired compartment; 2) pro-social effects measured on the basis of the
Vasopressin is a potent peripheral vasoconstrictor. Vasopressin has a direct action on the kidney. It also constricts peripheral vessels and causes contraction of the smooth muscle of the intestine, gall bladder and urinary bladder.. Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are relatively short lived unless given by continuous infusions. ...
Participant has successfully completed Studies 15-AVP-786-301, 15-AVP-786-302, 12-AVR-131, or 17-AVP-786-305.. Participants will be enrolled in the study for approximately 56 weeks (participants who have a follow-up visit 3 months after the last dose of treatment will be enrolled for approximately 64 weeks).. Approximately 1000 participants will be enrolled at approximately 250 centers globally.. All participants enrolled will receive AVP-786; the treatment dose assigned will be masked to the participant, investigator, study staff, and the sponsor.. ...
RESULTS: Surgery resulted in decreased ex vivo mHLA-DR expression, but no change in IL-10 or IL-12 plasma levels. mHLA-DR was low in LPS culture over the 4 postoperative days, whereas IL-10 release was increased and not counterbalanced by IL-12p40 production. The hormonal plasma pattern showed increased prolactin during anesthesia and peaks of cortisol, ACTH and arginine vasopressin during waking, but no alteration in catecholamine levels. mHLA-DR expression in LPS culture was not modified by plasma replacement, except immediately after surgery ...
Arginine HCL 400g, ALLMAX Nutrition Precursor for synthesis of Nitric Oxide (NO)* Promotes muscle mass* Arginine is considered a semi-essential amino acid. What that means is the body produces Arginine normally, but sometimes the body needs more than is available and Arginine needs to be supplemented. Food sources suc
Heres my AvP Requiem Blu-Ray Review. The film isnt a total loss, there are some genuinely good moments but the script is just awful.
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BACKGROUND: Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin microinjections into the anterior hypothalamus trigger robust grooming and flank marking, a stereotyped scent marking behaviors. The intensity and repetition of the behaviors induced by arginine vasopressin is somewhat reminiscent of Obsessive Compulsive Disorder in humans. The present experiments were carried out to test whether pharmacological agents used to alleviate obsessive compulsive disorder could inhibit arginine vasopressin-induced flank marking and grooming. RESULTS: Male golden hamsters were treated daily for two weeks with either vehicle, fluoxetine, clomipramine, or desipramine (an ineffective drug), before being tested for arginine vasopressin-induced flank marking and grooming. Flank marking was significantly inhibited in animals treated with fluoxetine or clomipramine
U.S., Jan. 12 -- ClinicalTrials.gov registry received information related to the study (NCT03014063) titled Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock on Jan. 4. Brief Summary: This is a prospective observational cohort trial evaluating a single plasma vasopressin concentration in patients receiving exogenous, adjunctive vasopressin for septic shock. The trial is designed to determine whether plasma vasopressin concentration influences the likelihood of hemodynamic response to exogenous vasopressin therapy. Study Start Date: November 2016 Study Type: Observational Condition: Septic Shock Intervention: Not Provided Recruitment Status: Recruiting Sponsor: The Cleveland Clinic Information provided by (Responsible Party): The Cleveland Clinic ...
TY - JOUR. T1 - The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis. AU - Maybauer, Marc O.. AU - Maybauer, Dirk M.. AU - Enkhbaatar, Perenlei. AU - Laporte, Régent. AU - Winiewska, Halina. AU - Traber, Lillian D.. AU - Lin, Chiidean. AU - Fan, Juanjuan. AU - Hawkins, Hal K.. AU - Cox, Robert A.. AU - Winiewski, Kazimierz. AU - Schteingart, Claudio D.. AU - Landry, Donald W.. AU - Rivière, Pierre J M. AU - Traber, Daniel L.. PY - 2014. Y1 - 2014. N2 - OBJECTIVE:: To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective as the mixed vasopressin type 1a receptor/vasopressin V2 receptor agonist vasopressor hormone arginine vasopressin when used as a titrated first-line vasopressor therapy in an ovine model of Pseudomonas aeruginosa pneumonia-induced severe sepsis. DESIGN:: Prospective, randomized, controlled laboratory experiment. SETTING:: University animal research facility. ...
OBJECTIVE: To investigate the involvement of serotonin (5-hydroxytryptamine - 5-HT) receptors in mediation of stress-induced arginine vasopressin (AVP) and oxytocin (OT) secretion in male rats.. DESIGN: Experiments on laboratory rats with control groups.. METHODS: Different stress paradigms were applied after pretreatment with intracerebroventricular infusion of saline or different 5-HT antagonists.. RESULTS: Restraint stress (5 min), hypotensive hemorrhage or dehydration for 24 h increased AVP secretion fivefold and OT secretion threefold. Swim stress for 3 min had no effect on AVP secretion, but increased OT secretion threefold. Ether vapor or hypoglycemia had no effect on AVP or OT secretion. The restraint stress-induced AVP response was inhibited by pretreatment with the 5-HT(2A+2C) antagonists ketanserin (KET) and LY-53857 (LY) and the 5-HT(3+4) antagonist ICS-205930 (ICS), whereas the 5-HT(1A) antagonist WAY-100635 (WAY) had no effect. The OT response to restraint stress was inhibited by ...
Axon terminals in the posterior pituitary store large quantities of the hormone vasopressin (AVP), buffering the synthesizing neurons in the hypothalamus against acute changes in physiological demand for hormone release. The dynamics of pituitary AVP content reflect the competing processes of release and synthesis. This report demonstrates substantial increases in pituitary AVP content in the maturing rat. Between 7-10 weeks of age, the total pituitary AVP content in the rat increases from 957 +/- 72 to 1667 +/- 160 ng. Cross-sectional data indicate a parallel relationship between body weight and pituitary AVP content. Nevertheless, weight maintenance does not affect age-related increases in AVP content. Decreasing demand for hormone release and synthesis by inducing hyponatremia blocks subsequent pituitary accumulation. After withdrawing the hyponatremic experimental conditions, animals resume accumulation of pituitary AVP, but do not catch up to age-matched controls. This indicates that increases in
Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. Their structures were characterized by 1H-NMR and HRMS, their biological activity was evaluated by in vitro and in vivo studies. The in vitro binding assay and cAMP accumulation assay indicated that these compounds are potent selective V2 receptor antagonists. Among them compounds 1n, 1t and 1v exhibited both high affinity and promising selectivity for V2 receptors. The in vivo diuretic assay demonstrated that 1t presented remarkable diuretic activity. In conclusion, 1t is a potent novel AVP V2 receptor antagonist candidate.
Rivalland, Elizabeth T.A., Iqbal, J., Clarke, I.J., Turner, Anne I. and Tilbrook, A.J. 2003, Distribution and co-localisation of corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP) and enkephalin (Enk) in the paraventricular nucleus (PVN) of the ewe, in Proceedings of the Endocrine Society of Australia, Endocrine Society of Australia, Melbourne, Vic., pp. 305-305. ...
Vasopressin-sensitive aquaporin-2 (Aqp2) in the apical membrane of the renal collecting duct (Fenton et al., 2008). Controls cell volume and thereby influences cell proliferation (Di Giusto et al. 2012). It plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled by the pituitary hormone arginine vasopressin, and defective trafficking results in nephrogenic diabetes insipidus (NDI). The crystal structure of Aqp2 has been solved to 2.75Å (Frick et al. 2014). In terrestrial vertebrates, AQP2 function is generally regulated by arginine-vasopressin to accomplish key functions in osmoregulation such as the maintenance of body water homeostasis by a cyclic AMP-independent mechanism (Olesen and Fenton 2017; Martos-Sitcha et al. 2015 ...
Increasing amounts of data suggest that affective disorders might be related to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, one of the stress-response systems. Arginine vasopressin (AVP) influences several symptoms, relevant to affective disorders, notable memory processes, pain sensitivity, synchronization of biological rhythms and the timing and quality of REM sleep. We examined whether genetic variations in the AVP receptor 1b gene (AVPR1b) could be associated with increased susceptibility to affective disorders using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). Five SNPs were identified in AVPR1b and genotyped in two well-diagnosed samples of patients with recurrent major depression and matched controls. In the Swedish sample, we observed significant allele (P=0.02) and genotype (P=0.01) association with SNP AVPR1b-s3, and in the Belgian sample, a borderline significant association with SNP AVPR1b-s5 (P=0.04). In both patient-control ...
In this study we found that, in 31 normal subjects, close to 90% of circulating arginine vasopressin (AVP), measured by radioimmunoassay, was associated with platelets. By using routine methods of centrifugation, which do not completely separate platelets, the normal range of plasma vasopressin was higher by twofold than the normal range in platelet-free plasma prepared by differential centrifugation, which was 1.4 +/- 1.0 sd pg/ml. Platelet vasopressin was 12.9 +/- 5.7 pg/ml. Patients with congestive heart failure had, on average, an elevated platelet-free plasma AVP, as did two patients with thrombocytopenia and one with thrombocytosis. Patients with essential hypertension had slightly high levels of platelet-free plasma AVP and demonstrated an abnormal inverse relationship between platelet-free plasma AVP and serum osmolality. Immunoreactive platelet vasopressin was slightly low in patients with essential hypertension and was subnormal in patients with congestive heart failure. These studies ...
Ever wonder what attracts you to your significant other and gives you a special bond with them? A study done on monogamous voles may have surprising ties with humans. The study (http://www.nature.com/neuro/journal/v7/n10/pdf/nn1327.pdf) has found that two chemicals found in voles (and in humans) Oxytocin (OT) and Arginine Vasopressin (AV), have found to be very important in pair bonding. The chemical Oxytocin has been shown to be very important in both males and females however more so to females then males. Males on the other hand, seem to be more effected by Arginine Vasopressin which leads them to be more aggressive, mark their territory and courtship. This is interesting because both sexes show the same number of receptors for both Oxytocin and Arginine Vasopressin. The study has been able to conclude that when Oxytocin is present in both sexes, pair bonding is increased even without mating. If Oxytocin is blocked for any reason pair bonding is prevented and the animals do not show signs of ...
Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically modified mice. However, neuroanatomical data on nonapeptidergic systems in mice are fragmentary, especially concerning the central distribution of OT. Therefore, we analyse the immunoreactivity for OT and its neurophysin in the brain of male and female mice (strain CD1). Further, we combine immunofluorescent detection of OT and AVP to locate cells co-expressing both peptides and their putative axonal processes. The results indicate that OT is present in cells of the neurosecretory paraventricular (Pa) and supraoptic hypothalamic nuclei (SON). From the anterior SON, OTergic cells extend into the medial amygdala, where a sparse cell population occupies its ventral anterior and posterior divisions. Co-expression of OT and AVP in these nuclei is rare. Moreover, a remarkable ...
The major findings of this study were that in the perfused rat CCD, the selective alpha-2 agonist dexmedetomidine reduced (1) AVP-stimulated Pf by 95% to 100%, (2) AVP-stimulated Pf in the presence of the PKC inhibitor staurosporine by 70% to 75% and (3) 8CPT-cAMP-stimulated Pf by 25% to 35%. Dexmedetomidine significantly reversed the AVP-induced effects on Vt and Rt. Overall, these findings indicate analpha-2-mediated mechanism that modulates AVP-dependent Na+ and water transport in the rat CCD, and the mechanism appears to include post-cAMP events in addition to the pre-cAMP event of alpha-2-induced inhibition of adenylyl cyclase.. Although the precise physiological function of renal alpha-2 adrenoceptors is not yet defined, it is well known thatalpha-2 agonists enhance urine output. Blandford and Smyth (1988, 1989) and Smyth et al. (1992) demonstrated that this effect is mediated in at least two separate sites in the kidney: one is non-AVP dependent, in which urine output is secondary to ...
Chelko SP, Schmiedt CW, Lewis TH, et al. Vasopressin-induced constriction of the isolated rat occipital artery is segment dependent. J Vasc Res. 2013;50(6):478-85. PMID: 24192548.. Mastropaolo M, Zizzo MG, Auteri M, et al. Arginine vasopressin, via activation of post-junctional V1 receptors, induces contractile effects in mouse distal colon. Regul Pept. 2013 Nov 10;187:29-34. PMID: 24185041.. Salazar M, Hu BB, Vazquez J, et al. Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock: Two Case Reports and Literature Review. J Intensive Care Med. 2013 Oct 7. [Epub ahead of print]. PMID: 24106070. ...
TY - JOUR. T1 - Neurohumoral and cardiopulmonary response to sustained submaximal exercise in the dog. AU - Kirlin, P. C.. AU - Kittleson, Mark D. AU - Johnson, L. E.. PY - 1987. Y1 - 1987. N2 - Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15° elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P , 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 ± 23 to 341 ± 35 and from 127 ± 27 to 222 ± 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 ± 0.3 to 3.1 ± 0.6 ng·ml-1·h-1 and from 98 ± 8 to 130 ± 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and ...
Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist. - Mechanism of Action & Protocol.
... is a man-made form of a hormone called anti-diuretic hormone that is normally secreted by the pituitary gland. Vasopressin acts on the kidneys and blood vessels. Vasopressin helps prevent loss of water from the body by reducing urine output and helping the kidneys reabsorb water into the body. Vasopressin...
Definition of vasopressins in the Definitions.net dictionary. Meaning of vasopressins. What does vasopressins mean? Information and translations of vasopressins in the most comprehensive dictionary definitions resource on the web.
Vasopressin (also, anti-diuretic hormone (ADH) or arginine vasopressin (AVP)) has been shown to be a very effective vasopressor, especially in circumstances…
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Vasopressin in cardiac surgery. There is limited evidence surrounding the use of vasopressin in cardiac surgery. Anecdotally, we use vasopressin, both during cardiopulmonary bypass and after, when patients have refractory shock. We have no idea what impact this intervention has on outcome. One small (unconvincing) study suggests that the addition of vasopressin is not associated with increased predicted mortality associated with cardiac surgery.27 Specifically, and with scant evidence, vasopressin has been advocated for refractory shock in this setting, especially when there is coexisting pulmonary hypertension.28 In early animal studies, vasopressin was shown to cause pulmonary vasodilation. However, in a well-conducted dog study, vasopressin was shown to cause pulmonary vascular constriction and to exert an important negative inotropic effect on the right ventricle.29 This was not the case when phenylephrine was used to augment systemic BP.29 It may be that at high doses vasopressin causes ...
Severn Biotech, Limited SBP0296 - [Arg8]-Vasopressin - SBP0296 - [Arg8]-Vasopressin AVP MW: 1084.4 H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Cys1-6, cyclic) Bell, J. et al. (1992) Int. J. Immunopharm. 14, 92. 5mg 25mg
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PMID 25016245] Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers executive functioning ...
Physiological admeasurement for diagnosing psychiatric disorders. Based on several beastly studies, NMDA receptor - amenable for mediating fast synaptic manual in the axial afraid arrangement (CNS) - can aswell adapt the absolution of arginine vasopressin (AVP) in the bloodstream. By aesthetic AVP absolution in bodies with a alkali solution, it was noticed that the allegation were constant with the above-mentioned beastly studies, i.e., participants challenged by abasement apparent an access in AVP and others grappling with schizophrenia displayed a abatement in AVP.. As of now, the in vivo appraisal of the NMDA receptors in bodies is not a possibility; therefore, the allegation of the abstraction are of abundant value, such that it uses the different blood-based biomarker to appraise the two brainy disorders. The analysis of this access has the abeyant to appraise any basal vulnerabilities of the patients harboring depressive affection or schizophrenia during psychiatric screening. In practice, ...
Tan, H.; Chen, L.; Li, X.; Li, M.; Zhao, M.: A target-driven DNA-based molecular machine for rapid and homogeneous detection of arginine-vasopressin. Analyst 145 (3), pp. 880 - 886 (2020 ...
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The thing about science is that its always evolving. As we learn more about how the human body works, the things we always held as true may change. Recently, in the media, there have been some claims that cholesterol might not be as bad for you as originally thought. Many are taking this to mean […]. ...
Title: Specificity of Three Vasopressin Receptor Antagonists. VOLUME: 8 ISSUE: 6. Author(s):Jeremy T. Saks, Barbara Truitt and Menachem Shoham. Affiliation:Case Western Reserve University, School of Medicine, Department of Biochemistry, 10900 Euclid Ave, Cleveland, OH 44106-4935, USA.. Keywords:Antagonist, GPCR, Receptor, Mozavaptan, Tolvaptan, Vaptan, Vasopressin, arginine vasopressin (AVP), hV1R, vasodilation, hyponatremia, hypervolemia, V2R, adenylyl cyclase. Abstract: Vasopressin receptor antagonists (vaptans) are a new class of drugs to treat congestive heart failure. Since there are three subtypes of the receptor located in different tissues, it is important to devise tailor-made vaptans to target the appropriate receptor subtype. The binding of three vaptans, OPC21268, mozavaptan and tolvapatan was measured to the human V1-vascular vasopressin receptor (hV1R). Whereas arginine vasopressin (AVP) binds to hV1R and hV2R with equal affinity, vaptans interact differently with the receptor ...