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Semantic Scholar extracted view of Ribonucleoprotein complexes associated with virions of Pichinde virus and Pichinde virus-infected cells by P. R. G. Young et al.
Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage-adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence. The abilities of adPIC and PIC3739 to induce tumor necrosis factor (TNF) in vivo and in cultured macrophages were compared. Infection with adPIC, but not PIC3739, was associated with detectable serum TNF that peaked in week 2 of infection. Tumor necrosis factor was found in the spleens of adPIC- and PIC3739-infected animals in week 1 of infection ; TNFα mRNA levels in spleens and livers of adPIC infected animals increased and remained high throughout infection, whereas PIC3739-infected organs showed down regulation of TNFα mRNA late in infection. Peritoneal macrophages explanted from adPIC-infected animals showed enhanced lipopolysaccharide-inducible TNF production. Altered regulation of TNF production may play a role in the pathogenesis of guinea
The established animal model for Lassa fever is based on the new world arenavirus Pichinde (PIC). Natural isolates of PIC virus are attenuated in guinea pigs, but serial guinea pig passage renders them extremely virulent in that host. We have compared the nucleotide sequences of the small RNA segments of two attenuated, low-passage variants of the PIC virus Munchique strain (CoAn 4763) and two virulent, high-passage derivatives. Missense mutations in the glycoprotein precursor (GPC) gene at codons GPC-119, GPC-140, and GPC-164 and the nucleoprotein gene (NP) codons NP-35 and NP-374 were most closely associated with virulence. Codon GPC-140 is predicted to represent a region of peak hydrophilicity of the glycoprotein 1 (GP1); it is conceivable that mutations at this site could influence virulence by altering B cell epitopes or virus attachment protein conformation.
We have investigated the double-layered carbon nano-onions (CNOs) C₂₀@C₆₀, C₂₀@C₈₀, C₆₀@C₁₈₀, C₆₀@C₂₄₀, C₈₀@C₂₄₀, and C₂₄₀@C₅₄₀ as well as their triple-layered analogues C₆₀@C₂₄₀@C₅₄₀ and C₈₀@C₂₄₀@C₅₄₀ with high-level electronic structure calculations. We were able to show that earlier work, which showed the free rotation of the inner fullerene in a CNO, does not extend to multilayered CNOs. We sh ...
Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean?
The clinical signs and gross and microscopic lesions of Lassa virus infection in the rhesus monkey are described. Of 17 monkeys infected with Lassa virus, nine died or were killed when moribund. The clinical signs were lethargy, aphagia, constipation, fever, conjunctivitis, and skin rash. Pulmonary congestion, pleural effusion, pericardial edema, hydropericardium, and a few visceral hemorrhages were present grossly. Major microscopic lesions were necrotizing hepatitis and interstitial pneumonia. Other microscopic changes were present in the heart, small intestine, spleen, lymph nodes, kidney, urinary bladder, adrenal glands, and central nervous system however, most of these lesions were mild. In fact, death could not always be attributed to the morphologic changes therefore, function alterations must be examined.
Two days after infecting groups of guinea pigs with a lethal dose of Lassa virus, the scientists treated the rodents daily for two weeks with either ribavirin, low doses of favipiravir, or high doses of favipiravir. They also evaluated the effect of high-dose favipiravir in the rodents that began treatment five, seven or nine days after infection. All of the animals that received high-dose favipiravir were completely protected from lethal infection; animals treated seven or nine days after infection had begun showing signs of disease, but their conditions quickly improved when treatment began. Those animals in the low-dose favipiravir group showed mild to moderate signs of disease, but those symptoms resolved after about one week of treatment. The animals treated with ribavirin appeared normal during the treatment phase but developed severe disease shortly after treatment ended. ...
Lassa fever is an acute viral haemorrhagic illness of 1-4 weeks duration that occurs in West Africa. Lassa Fever, Lassa Fever Symptoms, Lassa Fever Prevention
Lassa fever is an acute viral haemorrhagic illness of 1-4 weeks duration that occurs in West Africa. Lassa Fever, Lassa Fever Symptoms, Lassa Fever Prevention
Lassa Virus Essay, Research Paper The Lassa virus is a vulgar virus with a high mortality rate and an expensive cure. Lassa was strange to me because I have never heard of the virus before. As I was reading in my research, I began to realize the risk the virus has on people.
Virulent and highly transmissible member of the Arenaviridae whose normal host is a rodent (Mastomys natalensis ) ; first recorded from Nigeria
Researchers have uncovered structural and functional details of a key Lassa virus protein; this new information may aid the development of vaccines.
Pull over to the side of the road if you need to make a call or if you are receiving an incoming call. This will ensure that you are safe and that the other drivers on the road are safe too
Looking for Guanarito virus? Find out information about Guanarito virus. parasite with a noncellular structure composed mainly of nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living... Explanation of Guanarito virus
Lassa virus (LASV) is endemic in West Africa and induces a viral hemorrhagic fever (VHF) with up to 30% lethality among clinical cases. The mechanisms
According to a release issued in Monrovia, from January 1, 2019 to December 31, 2019, NPHIL, through the National Reference Laboratory, recorded 50 confirmed cases of Lassa fever. Of the 50 cases, 18 deaths were recorded, a Case Fatality Rate (CFR) of 36%. This 2019 CFR is a significant improvement compared to the 2018 CFR of 66%.. In view of the aforementioned recent Lassa fever cases, and the fact that NPHIL has responded to an average of one Lassa fever case per week in recent months, NPHIL, in collaboration with the Ministry of Health, has deemed it expedient to announce that Liberia has had a continuous Lassa fever outbreak.. The release also disclosed that although Lassa fever is not new to Liberia, it is a potentially deadly viral disease that requires urgent attention. The disease is spread by rodents or rats and through close contact with affected persons. Lassa fever is not as infectious as Ebola and rarely spread from persons to persons. However, health workers, communities, and the ...
To determine whether Lassa virus was circulating in southern Mali, we tested samples from small mammals from 3 villages, including Soromba, where in 2009 a British citizen probably contracted a lethal Lassa virus infection. We report the isolation and genetic characterization of Lassa virus from an area previously unknown for Lassa fever.
Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus
Los síndromes infecciosos asociados a arenavirus en América del sur son cuatro: síndrome febril de origen viral; fiebres hemorrágicas con o sin compromiso neurológico; meningitis asépticas y meningo-encefalitis. Entre los Arenavirus del nuevo mundo, está el complejo Tacaribe donde se encuentran los virus: Junín (Argentina), Guanarito (Venezuela), Machupo (Bolivia) y Sabiá (Brasil), que se caracterizan por causar fiebres hemorrágicas. En Colombia fue aislado el arenavirus Pichindé en 1965, del roedor Oryzomys albigularis, en el valle de Pichindé (Valle del Cauca). Este arenavirus produce una infección persistente en su hospedero y no es patógeno para el hombre. Hay evidencias de la circulación del virus Guanarito en roedores de Córdoba, pero no existen casos diagnosticados en humanos; en Sincelejo (Colombia) se detectó el genoma del virus coriomeningitis linfocítica en cerebros de roedores Mus musculus. El diagnóstico se basa en el conocimiento de la epidemiología local y la sospecha
The study set to assess the knowledge and attitude to Lassa fever among primary care providers. Structured questionnaires were administered to consenting primary care workers in Private and Primary health centres in Ekpoma. Data analysis was carried out using SPSS version 15. One hundred and thirty five (135) health workers participated in the study. One hundred and thirty one (97.0%) respondents had previously heard of Lassa fever. Overall knowledge of Lassa fever was poor for 51 (38.9%), and fair for 54 (41.2%) and good for 260 (19.8%). Hand gloves were stated as the most useful personal protective gear when dealing with a patient with Lassa fever. Fifty six (42.7 %) felt their level of knowledge was sufficient for them to safely and effectively handle a patient, 126 (96.4%) expressed their desire to know more about Lassa fever. The primary care health worker in a rural area is the one most likely to be the first point of call for persons seeking orthodox medicine. It is therefore essential ...
Health & Fitness · Lassa fever virus is an animal-borne or zoonotic, acute viral illness which was discovered in the year 1969. This virus killed two missionary nurses in Nigeria in 1969...
The first case of the current outbreak was reported from Bauchi in November, 2015. This was followed by cases reported by Kano State, and subsequently the other states mentioned above. Lassa fever is an acute febrile illness, with bleeding and death in severe cases, caused by the Lassa fever virus with an incubation period of 6-21 days. Lassa fever was first detected in Nigeria in 1969.The number of recorded cases peaked in 2012 when 1,723 cases with 112 fatalities were recorded. It has continued to decline since then ...
Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans,
Junin virus buds at CD9-enriched sites. JUNV-A647 viral particles stained with either a CD9 antibody conjugated to PE (a) or Cholera Toxin B (CTB) conjugated to
BACKGROUND INFORMATION ABOUT CONVALESCENT PLASMA: Passive immunity has proven effective for cytomegalovirus (CMV), hepatitis B virus, rabies, tetanus, varicella, certain SARS variants, Argentine Hemorrhagic Fever, and various other illnesses. Convalescent plasma has been cited as a potential therapy for viral infection dating back to the 1918 Spanish influenza A (H1N1) pandemic. Since that time, convalescent plasma as passive immune therapy has been evaluated in the treatment of: Ebola, SARS coronavirus (SARS-CoV), 2009 pandemic influenza A (H1N1), Argentine Hemorrhagic Fever, CMV, Parvovirus B19, and others. Furthermore, a February 2020 WHO report states The cellular infectivity of the isolated viruses could be completely neutralized by the sera collected from convalescent patients. [Source: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf ] ABOUT CERUS Cerus Corporation is dedicated solely to safeguarding the worlds blood supply and ...
January 7, 2016 - Lassa Fever Outbreak Kills 35 In Ibadan Oyo , Niger, Taraba, Kano, Rivers & Edo States, 76 Quarantined At least 35 people have
Funmi,. Its good to be loyal. But when lives are being lost, let us call a spade a spade. MOH has been deafeningly silent on Lassa Fever. Not the same as when Ebola was the issue. HEre is why a lot of noise is good around Lassa fever. First, it will keep the masses on the alert. Second, it will ensure dissemination of public health messages about symptoms, what to do when you have symptoms. Three, it will alert the medical community from doctors to nurses. Four, it will foster discussions at state and local levels about allocation of resources specially for this issue. Now, what is the role of the feds? The role of the federal government led by PMB and his minister for health is to initiate this communication action plan, define a coordinating strategy for collecting surveillance data (a key element in owning and subduing epidemics), set up a coordination strategy that is known to health officials, other officials and the general public, ascertain where resources are needed, and mobilize ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
Key facts Lassa fever is an acute viral hemorrhagic illness, with a duration of 1-4 weeks duration that occurs in West Africa. The Lassa virus is transmitted to humans via contact with food or household items contaminated with rodent urine or faeces. Person-to-person infections and laboratory transmission can also
The Nigeria Centre for Disease Control, on Tuesday, declared the emergency phase of the Lassa fever outbreak in the country over.
The death toll from a Lassa fever outbreak in northern Nigeria has risen to 41, the Nigeria Center for Disease Control announced this week.
Kayode Idowu, Maiduguri Twenty persons have been quarantined in Borno State as Lassa fever spread to the state. Briefing newsmen on Wednesday in ...
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog. 2010 Sep 16; 6(9):e1001038 ...
Ebola also claimed victims in Nigeria...and the government there won plaudits for quickly containing the outbreak. Now though another virus is spreadi...
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This is the first case of Lassa fever to be imported from Mali to the United Kingdom. This paper discusses the investigations, the virological analysis, the surveillance and management of contacts undertaken following a case of Lassa fever.
TY - JOUR. T1 - Experimental Lassa virus infection in the squirrel monkey. AU - Walker, D. H.. AU - Wulff, H.. AU - Murphy, F. A.. N1 - Copyright: Copyright 2004 Elsevier B.V., All rights reserved.. PY - 1975. Y1 - 1975. N2 - Experimental Lassa virus infection was investigated in a nonhuman primate in order to elucidate the target organs of the viral infection and the course of pathologic events. Four squirrel monkeys (Saimiri scirreus) were inoculated intramuscularly with Lassa virus and sacrificed for organ titrations and histopathology, one each day, on Day 7, 12, 14, and 28 after inoculation. The animals showed a variable clinical course, with an incubation period of 8 to 18 days. The virus was demonstrated to be virtually pantropic; however, lymph node, liver, and kidney were key early targets. After the onset of overt disease, patterns of lymphoreticulotropism, hepatotropism, nephrotropism, adrenotropism, and persistent viremia were evident. Complement fixing antibody failed to develop ...
Lassa virus belongs to the Arenaviridae family and causes Lassa fever, also known as Lassa haemorrhagic fever (LHF). It is a haemorrhagic illness that occurs between one and three weeks after infection.. Lassa fever is a zoonotic disease, meaning it passes from animals to humans. The natural host of Lassa virus is the rodent Mastomys natalensis, otherwise known as the Natal multimammate mouse or rat.. The virus is spread when a person comes into contact with items contaminated with the rodents urine or faeces - for example, by handling objects, eating or through open wounds. It can also be inhaled.. Lassa virus can pass from person to person via bodily fluids, and can spread in healthcare settings if suitable precautions are not taken.. ...
January 26, 2016 - Lassa Fever Virus Disease Hits Abeokuta Ogun State, 19 FUNAAB Students Isolated 19 suspected primary carriers of Lassa fever in Ogun
TY - JOUR. T1 - Attenuated replication of lassa virus vaccine candidate ML29 in STAT-1 -/- mice AU - Johnson, Dylan M.. AU - Jokinen, Jenny D.. AU - Lukashevich, Igor S.. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Lassa virus (LASV), a highly prevalent mammalian arenavirus endemic in West Africa, can cause Lassa fever (LF), which is responsible for thousands of deaths annually. LASV is transmitted to humans from naturally infected rodents. At present, there is not an effective vaccine nor treatment. The genetic diversity of LASV is the greatest challenge for vaccine development. The reassortant ML29 carrying the L segment from the nonpathogenic Mopeia virus (MOPV) and the S segment from LASV is a vaccine candidate under current development. ML29 demonstrated complete protection in validated animal models against a Nigerian strain from clade II, which was responsible for the worst outbreak on record in 2018. This study demonstrated that ML29 was more attenuated than MOPV in STAT1 -/- mice, a small animal ...
Lassa fever has killed 100,000 Nigerians - Expert. Prof. Dennis Agbonlahor, a member of the National Committee on the Control of Lassa fever, says the virus had killed more than 100,000 Nigerians since the discovery of the virus in the country, calling for more funding and political will to combat the scourge.. Agbonlahor said this while presenting a paper titled Combating Lassa fever: A National Health Challenge, organised by the University of Benin on Friday in Benin.. The expert therefore, commended the Federal Government for creating moreawareness about the disease calling for sustenance of the awareness initiative.. Also, he applauded the trials of newly developed Lassa virus vaccine in the country.. He said that the vaccine developed by a combined team from the U.S. Army Medical Research Institute for Infectious Diseases and the Public Health Agencies of Canada was a promising vaccine for controlling Lassa fever.. According to him, this live and harmless vaccine, which is wrapped in a ...
Neighbor-joining phylogenetic tree of Machupo virus derived from the glycoprotein precursor gene sequence. The neighbor-joining and maximum likelihood analyses
Five staff at the hospital; however, only two died from the sometimes deadly Lassa, which is an Arenavirus, different from that of Marburg and Ebola, which are filoviruses .. No new cases have been reported, but vigilance is needed, as explained Dorothee Kinde Gazard, Minister of Health: We have identified and continue to identify subjects contacts to follow 21 days. And I would like to appeal to all the Beninese for they occur in health centers at the onset of influenza-like illness that begin with fever.. The WHOs representative in the country, Youssouf Gamatie, was quoted as saying in the Benin media: Its lucky that we have detected it in the initial phase.. According to the WHO, Lassa fever is an acute viral hemorrhagic illness caused by Lassa virus, a member of the arenavirus family of viruses. It is transmitted to humans from contacts with food or household items contaminated with rodent excreta. The disease is endemic in the rodent population in parts of West Africa. Person-to-person ...
Explanation:. Lassa fever or Lassa hemorrhagic fever (LHF) is caused by Lassa virus. This disease is mainly prevalent in West Africa countries such as Nigeria, Liberia, Sierra Leone, Guinea, and Ghana. It results in 5000 deaths every year. Its a zoonotic disease transmits to human from a species of mouse. ...
This resource examines the sites of interactions between humans and the multimammate mouse, Mastomys natalensis. It presents findings such as new arenaviruses in other African rodents and in snakes, that argue preferably toward the host-switching concept. The recent emergence in Sierra Leone, the absence of virus positive Mastomys between the two endemic zones and poor virus diversity in the Mano River area also point in the direction of a unique import of Lassa virus from Nigeria to Sierra Leone during the 19th century. This resource also discusses the hypothesis of human displacements through the Atlantic slave trade and its abolition in 1807.. Read more ...
Two persons, including a 36-year-old pregnant woman, have died at the Lagos University Teaching Hospital, LUTH, Idi-Araba, after being treated for Lassa fever.. Also, not less than 100 different hospital workers, who were exposed to the index case, including a resident doctor from the Department of Anatomic and Molecular Pathology are currently under close observation in LUTH, THISDAY investigations have shown.. The resident doctor was said to have taken part in the autopsy of the late pregnant woman. He is currently at the surveillance unit of the hospital, where he is being treated.. The Chief Medical Director, LUTH, Prof. Chris Bode, told THISDAY that the two patients died within a few days of admission as they presented late to the hospital in spite of efforts of the health workers to save their lives, adding that the late pregnant womans post-mortem examination was conducted before her Lassa fever status was eventually suspected and confirmed.. The Centre for Disease Control (CDC) in ...
FBI will investigate the Texas biolab where a deadly virus went missing, according to the Centers for Disease Control and Prevention.
According to him, we demonstrated and emphasised to the general public that all it takes to see a doctor is simply the decision to do so; we also organised a press conference on Lassa fever outbreak and in liaison with other stakeholders, ensured that Enugu State was Lassa free, while our committee on hemorrhagic fever worked closely with the state ministry of health and management of all hospitals to fight Lassa.. He also disclosed that the association was actively involved in the fight against quacks and impersonation of the medical profession by disgruntled elements, adding that the leadership during the period launched into the radio and TV waves, jingles on the best way to assess quality health care services and the need to make a qualified medical doctor the point of call on health issues.. He recalled that during their courtesy visit to the Enugu State Governor, Hon. Ifeanyi Ugwuanyi, at the Government House, the NMA handed a framework document on the road map towards effective health ...
VHFC partner, Corgenix Medical Corporation, has developed the first commercialized diagnostic test that enables rapid diagnosis of Lassa viral hemorrhagic fever.. This 15-minute test has the potential to completely change stye way Lassa fever is detected and treated, said Douglas Simpson, Corgenix President.. Read the full press release on the Corgenix website. ...
Nucleic Acid: Plasmid for expression of the LCMV S-segment with heterologous arenavirus GP - Machupo (Expression plasmid, Diagnostic reagent, Derived product, Nucleic Acid, Cloned nucleic acid)
The Ogun State Commissioner for Health, Babatunde Ipaye has confirmed the outbreak of Lassa fever saying a 20-year-old patient tested positive for the virus and has been moved to one of the isolation centres set up by the state government ...
Samuel Awoyinfa, Tobi Aworinde, Bukola Bakare and Joy Marcus There is palpable fear in Ogun State over a suspected case of Lassa fever in the stat...
Adamawa State has recorded its first case of death from Lassa Fever. The victim, a personnel of the Nigerian Security and Civil Defense Corps (NSCDC) identified as Gabriel Ambe, serving in Gembu, Taraba, is said to have died on Thursday at the Federal Medical Centre in Yola.
A team of British experts is being sent to Nigeria to help the country contain the biggest outbreak of Lassa fever in recent years.
Dr. Idris is a famous health specialist, There were some controversies came up on their hospital but he refused all the controversies and clearly stated that lassa fever patients will get recovered soon by the treatment of his hospital.. ReplyDelete ...
In collaboration with scientists at Radboud University (Netherlands) and Harvard University (USA), the laboratory of Thijn Brummelkamp (Netherlands Cancer Institute, Adjunct Principal Investigator at CeMM) identified genes that are required for coupling sugar groups to the dystroglycan protein.
Ebola virus disease (EVD) is a dreaded viral disease and the first case of the virus was recorded in 1976 in Zaire which was where it g ...
For 2016, EU/EEA countries reported three cases of Lassa fever. Germany reported two cases, and Sweden reported one case. These were the first Lassa fever cases reported by EU/EEA countries since 2009 when two cases were reported by the United Kingdom. ...
Free, official coding info for 2021 ICD-10-CM A96.2 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
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