Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation<...
TY - JOUR. T1 - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. AU - Fürstenberger, Gerhard. AU - Epp, Nikolas. AU - Eckl, Katja Martina. AU - Hennies, Hans Christian. AU - Jørgensen, Claus. AU - Hallenborg, Philip. AU - Kristiansen, Karsten. AU - Krieg, Peter. PY - 2007/1/1. Y1 - 2007/1/1. N2 - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment ...
LOX-DB - LipOXygenases DataBase - Literature
Two types of 12-lipoxygenase that catalyze the transformation of arachidonic acid to 12(S)-hydroperoxyeicosatetraenoic acid (12-HPETE) have been previously classified into platelet-type and leukocyte-type categories. Here, we document, for the first time, a molecular characterization of both forms within the same species. The amino acid sequence of the murine platelet 12-lipoxygenase deduced from its cDNA is 58% identical to the murine spleen/leukocyte 12-lipoxygenase. Expression constructs carrying the cDNAs for the two 12-lipoxygenase forms were introduced into human embryonic kidney 293 cells. The platelet-type enzyme metabolized arachidonic acid exclusively to 12-HPETE, whereas the leukocyte-type enzyme formed both 12-HPETE and 15-hydro(pero)xyeicosatetraenoic acid in a ratio of approximately 3:1. Linoleic acid was metabolized to a similar extent by the latter enzyme to 13-hydro(pero)xyoctadecadienoic acid but not by the platelet enzyme. Mutagenesis and deletion of the highly conserved ...
The Effects of Leukocyte-Type 12/15-Lipoxygenase on Id3-Mediated Vascular Smooth Muscle Cell Growth | Arteriosclerosis,...
Convincing evidence exists implicating leukocyte-type 12/15-LO as a key player in the development of atherosclerosis and restenosis. KO of the 12/15-LO gene in apolipoprotein E- and LDL receptor-deficient mice, 2 models of robust atherosclerosis, resulted in a marked decrease in atherosclerosis development in vivo.5,7 Marked upregulation of 12/15-LO occurred in VSMCs after balloon carotid injury in rats, and restenosis was significantly blocked with a pharmacological 12/15-LO inhibitor as well as a specific ribozyme targeted to cleave 12/15-LO.4,27 Many events and pathways involving 12/15-LO have been proposed to contribute to atherosclerosis and restenosis. Much is understood concerning the ability of 12/15-LO within macrophages to participate in the oxidation of LDL, an early event in vascular lesion formation.2,7-9,28 However, 12/15-LO activity and products also increase in endothelial cells and VSMCs at the time of injury and in response to growth factors and cytokines. 12S-HETE, the ...
LOX-DB - LipOXygenases DataBase - General Information about Lipoxygenases
A LOX definition according to enzyme classification is linoleate: oxygen oxidoreductase (for plant LOX) and arachidonate: oxygen oxidoreductase (for mammalian LOX). Historically LOX are classified according to their positional specificity of the dioxygenation of their most common substrates linoleate (C-18) in plants, and arachidonic acid (C-20) in mammals. Accordingly, a LOX reacting at the ω-6 position of the substrate (as counted from the tail end of the fatty acid) in plants is referred to as a 13-LOX (alternate: linoleate ω6-LOX) and in mammals as a 15-LOX (alternate: arachidonate ω6-LOX). In plants 9-, and 13-LOX and in mammals, 5-, 8-, 12- and 15-LOX are known. When necessary, the stereoconfiguration is specified (e.g. 12S-LOX and 12R-LOX). In mammals, isoenzymes that exhibit the same position-specificity are named additionally after the prototypical tissue of their occurrence (e.g. platelet-type, leukocyte-type and epidermis-type 12S-LOX) [1 ...
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User contributions for Ete - Lesswrongwiki
21:30, 9 February 2014 (diff , hist) . . (+18) . . m Eliezer Yudkowsky (Changed link which previously redirected back to this page to a more useful link to EYs LW posts. Simplified wikicode in a link.) ...
User contributions for Ete - Lesswrongwiki
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Complete information for ALOX15 gene (Protein Coding), Arachidonate 15-Lipoxygenase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Ete was a five-year-old boy. At 2:00 in the morning, he woke up screaming with pain from a headache. Mom gave him Tylenol but he was not able to go back to sleep. By the time I saw him, he had suffered with headache for almost twenty-four hours. His vital signs were normal and he had no other complaints or recent illnesses, but Ete looked miserable, holding the top of his head with tears in his eyes.. In adults, sudden on-set headaches like this may be caused by a subarachnoid hemorrhage. This is a very serious condition caused by the rupture of an abnormal blood vessel, usually an aneurysm, at the base of the brain. If the aneurysm is not discovered and treated, complications can lead to brain damage or death.. The work-up for adult patients with this kind of headache is very straightforward. A CT scan of the head shows brain hemorrhage in about ninety percent of people who have one. If the CT is normal, we recommend a lumbar puncture to make sure there is no blood in the fluid that bathes the ...
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GFIT result for T01044
sp:LIDS_GAEGR] linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC:1.13.11.60 5.4.4.6); K17864 linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase [EC:1.13.11.60 5.4.4.6] ...
GFIT result for T01611
sp:LIDS_GAEGR] linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC:1.13.11.60 5.4.4.6); K17864 linoleate 8R-lipoxygenase / 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase [EC:1.13.11.60 5.4.4.6] ...
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VZORKA AQUANATURE System hydro Vyhladzujúci hydratačný očný krém (600320)
Vzorka obsahuje:AQUANATURE System hydro Očný krém 2ml AQUANATURE System hydro je sériová starostlivosť určená pre nedostatočne hydratovanú pleť, ktorá vykazuje prvé vrásky. Viaže veľké množstvo vlhkosti v pleti a zvlhčuje pokožku zvnútra, vyplňuje jemné línie a...(600320)
Optimum PLATINUM HYDRO WHEY 1590g | nejv t nab dka protein v R
Optimum PLATINUM HYDRO WHEY 1590g, Optimum Nutrition, : Proteiny na r st sval nad 1500g, Koncentrace: 76-90%, Platinum Hydro Whey je 100% ist hydrolyzovan syrov tkov protein s pr m rnou molekul rn hmotnosti kolem 1 000 dalton . nik tn peptidov struktura zaji uje nejrychlej a naprosto ... - V e pro fitness, kulturistiku a aerobik. Posilovac stroje a sportovn v iva pro dom c a komer n posilovny.
UV systems for spas & hydro pools - Case Study on Environmental XPRT
Article UV systems for spas & hydro pools - Case Study. With the rise of health centres and leisure clubs throughout the UK, a key feature in many modern facilities is the inclusion of spas and hydro pools. As a specialist aquatic application, spas a...
Hard Hat CAP STYLE custom hydro dipped , OSHA approved ICE SKULL LIMITED EDITION | eBay
For sale a genuine WET WORKS IMAGING hydro dipped hard hat. That has been custom dipped and then clear coated for that mirror like shine you see in our photos. We are the only hydro dippers approved by the manufacturer to dip the Ridgeline hard hat.
Boost Mobile Unlimited Starter Plan with Kyocera Hydro Icon | Wirefly
Get information about the Boost Mobile Unlimited Starter plan with the Kyocera Hydro Icon. The Kyocera Hydro Icon is compatible with the Boost Mobile Unlimited Starter Plan on the Boost Mobile network.
MTM Hydro 16.5027 Hydrojet 7.5 Orifice Turbo Nozzle w/ QC Filter 5800 PSI
Buy MTM Hydro 16.5027 Direct. Free Shipping. Check the MTM Hydro Hydrojet 7.5 Orifice Turbo Nozzle w/ QC Filter (5800 PSI) ratings before checking out.
Car Hire The SSE Hydro from | Expedia
Looking for a cheap car hire in The SSE Hydro? We compare all major car hire companies to find you the best car hire deals in The SSE Hydro, Scotland. Free cancellation on short & long term car hire.
Hydro Tabs | Electrolytes For Hydration | For Goodness Shakes
Looking to replace lost fluids from your workout? For Goodness Shakes hydro tabs have you covered! One hydro tab contains 5-ion electrolytes to help you stay hydrated all day long.
Nutrient
Deschamps, J. D., Gautschi, J. T., Whitman, S., Johnson, T. A., Gassner, N. C., Crews, P., & Holman, T. R. (2007). Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg ...
Hydro~San Plus Consignment Program by Specialty Health Products
Want to upgrade your current Hydro~San Plus or need to reduce the quantity of machines you have on hand? Then we are here to help you, why not consign your device with the help of Specialty Health Products.
Hydro blue mist & boost skin care formulation
The Hydro Blue Mist & Boost skin care formulation provides long-lasting hydration, protection against pollution, UV and blue light. Enriched with essential vitamin and skin bioactive ingredients.
Hydro Peptides 8000 Fair Power Survival 400 tbl za 799 K
Hydro Peptides 8000 Fair Power Survival 400 tbl - aminokyseliny - fitness,protein,proteiny,Amix,Nutrend,Myprotein,proteiny,zhubnout,kulturistika,hubnuti,cviky,svaly
Hydro International realigns US business structure after acquisition growth on Environmental XPRT
Hydro International, a leading provider of environmentally sustainable products and innovative solutions that control and treat stormwater, wastewater and ...
Neutrogena Hydro Boost Quru Dəri üçün Üz Yuma Geli | BODYCARE
Neutrogena Hydro Boost üz üçün təmizləyici gel çirkləri, yağlılığı və kosmetik vasitələrinin qalıqlarını aparır. Məsamələri təmizləyir.
Herbs that mimic hydro cortizone - Oxyhives for hives relief - Jun 17, 2017
Herbs that mimic hydro cortizone - Hypoglycemia without Diabetes - Benjimester on HubPages. Oxyhives is natural homeopathic solution to relieve the miserable symptoms of hives.
Nuclear and hydro the core of sustainability
The most sustainable national power systems in the world combine nuclear with hydro for mass low-carbon generation, a World Energy Council study shows.
Classic Tube CTO1015-SS: Chevy / GMC Pick Up Power Steering Line Set With Hydro Boost System -1996 1997 1998 | JEGS
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Gentlemens Tonic - Advanced Derma-Care Hydro Fresh Cream Cleanser 100ml/3.4oz - Cleansers | Free Worldwide Shipping |...
Potrošite €138,66 za besplatnu dostavu bilo gdje u svijetu | Advanced Derma-Care Hydro Fresh Cream Cleanser Perfect for all skin types
Dry Cleaning Plant in WLA w/Hydro Carbon Machine for sale in
Buy a Dry Cleaning Plant in WLA w/Hydro Carbon Machine business for sale and hundreds more Other Services (except public administration) businesses for sale on linkbusiness.com
Phenomenex HPLC Application #17941: Polar Probes on Synergi Hydro
HPLC Application #17941: Polar Probes on Synergi Hydro. Column used: Synergi™ 4 µm Hydro-RP 80 Å, LC Column 150 x 4.6 mm, Ea Part#: 00F-4375-E0
HYDRO COMPLEX 24H SOFT KREMA - Linea Kozmetika
Lahka negovalna in zaščitna krema za maksimalno, dolgo trajajočo navlaženost. Obogatena je z izredno učinkovitim hydro complex, ki nudi takojšnjo ...
Easy Hydro Grow - Bloom - Kulture
EHG - Bloom is one of the nutrients in the Easy Hydro Grow three part liquid nutrient system (Grow/Micro/Bloom). These nutrients have been proudly manufactured in South Africa since 2014. GHE nutrients are suitable for all kinds of soil-less growing including aeroponics, bubbleponics, deep-water culture, nutrient film,
Hydro System NFT
Culture Indoor, spécialiste de lhydroponie et Hydro System NFT, NFT Systems, System and irrigation : nombreuses marques et références à découvrir !
Diaphragm Hydro Pneumatic Tanks - Elbi of America
ELBI of America in Houston, TX is a leading provider of Diaphragm Hydro Pneumatic Tanks with the latest development in well-tank technology.
Hydro fights RCMP on power records | Drugs-Forum
North Vancouver RCMP have backed off on a request that would have forced BC Hydro to turn over the records of more than a thousand North Vancouver homeowners using large amounts of power to...
Neutrogena® Hydro Boost Hydrating Tint
Formulated with hyaluronic acid, Neutrogena® Hydro Boost Hydrating Tint is the first water gel foundation that applies flawlessly to create a fresh look. Neutrogena
The Pitlochry Hydro Hotel, UK - Booking.com
The Pitlochry Hydro Hotel is located in Pitlochry, just 24 miles from Perth. Guests can enjoy the on-site bar. Free private parking is available on site.
HYDRO FLASK | Growler Wide Mouth - 64 Ounce
The 64oz Wide Mouth-Growler by Hydro Flask lets you fill up on your favorite brew while keeping it ice-cold for a post hike pint.
Hydro Flask Standard Mouth Flex Cap | Next Adventure
Strong yet flexible, Hydro Flasks Standard Mouth Flex Cap is the perfect companion for spontaneous campouts, epic road trips, and everything in between.