TY - JOUR. T1 - Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors results from the dallas heart study. AU - Tsimikas, Sotirios. AU - Clopton, Paul. AU - Brilakis, Emmanouil S. AU - Marcovina, Santica M.. AU - Khera, Amit. AU - Miller, Elizabeth R.. AU - de Lemos, James A. AU - Witztum, Joseph L.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2009/4/7. Y1 - 2009/4/7. N2 - Background-Elevated levels of oxidized phospholipids (OxPLs) on apolipoprotein B-100 particles (OxPL/apoB) are associated with cardiovascular disease and predict new cardiovascular events. Elevated lipoprotein (a) [Lp(a)] levels are a risk factor for cardiovascular disease in whites and also in blacks if they carry small apolipoprotein(a) [apo(a)] isoforms. The relationship of OxPL/apoB levels to race/ethnicity, cardiovascular risk factors, and apo(a) isoforms is not established. Methods and ...

TY - JOUR. T1 - Plasma apolipoprotein B-48 transport in obese men: A new tracer kinetic study in the postprandial state. AU - Wong, A.T.Y.. AU - Chan, Dick. AU - Pang, Jing. AU - Watts, Gerald. AU - Barrett, Hugh. PY - 2014/1. Y1 - 2014/1. N2 - Context: The mechanisms responsible for impaired chylomicron metabolism have not been adequately investigated in obese subjects. Objective: We aimed to compare apolipoprotein (apo) B-48 kinetics in obese and lean men by developing a new model to describe the kinetics of apoB-48 particles in the postprandial state. Design, Setting, and Patients: Seven obese and 13 age-matched lean men were given an oral fat load. apoB-48 tracer to tracee ratios were measured after intravenous d3-leucine administration using gas chromatography-mass spectrometry. Kinetic parameters were derived using a multicompartmental model. Outcomes Measures: Plasma total and incremental apoB-48 0-10 hour areas under the curve as well as apoB-48 secretion and fractional catabolic rate. ...

American College of Cardiology Foundation - Clinical Research , October 2012. Objectives This study sought to assess the long-term predictive value and net reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation-specific epitopes (OSEs).. Background OSEs are immunogenic, proinflammatory, and proatherogenic. The long-term predictive value and net reclassification of OSEs for risk of CVD events are not known.. Methods Oxidized phospholipids on apolipoprotein B-100 (OxPL/apoB) and immunoglobulin (Ig)-G (IgG) and IgM autoantibodies to malondialdehyde-modified, low-density lipoprotein (MDA-LDL) and copper-oxidized LDL (Cu-OxLDL) were measured in 765 subjects in 1995 and 656 subjects in 2000 in the Bruneck study, representing 45- to 84-year-old men and women from the general community. Read more. ...

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Apolipoproteins are carrier proteins that bind lipids to form water-soluble lipoprotein particles that can be carried through blood and lymph. Several different classes and subclasses of apolipoproteins are known. Apolipoprotein B (ApoB) is the primary apolipoprotein in chylomicrons (lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins) and low-density lipoprotein (LDL). It is also known as FLDB and LDLCQ4. High levels of ApoB can lead to plaques that cause atherosclerosis, and ApoB levels can be a better indicator of heart disease risk than total cholesterol or LDL. The APOB transcript is subject to tissue-specific RNA editing, resulting in two major isoforms, ApoB-100 and ApoB-48.. ...

Apolipoproteins are carrier proteins that bind lipids to form water-soluble lipoprotein particles that can be carried through blood and lymph. Several different classes and subclasses of apolipoproteins are known. Apolipoprotein B (ApoB) is the primary apolipoprotein in chylomicrons (lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins) and low-density lipoprotein (LDL). It is also known as FLDB and LDLCQ4. High levels of ApoB can lead to plaques that cause atherosclerosis, and ApoB levels can be a better indicator of heart disease risk than total cholesterol or LDL. The APOB transcript is subject to tissue-specific RNA editing, resulting in two major isoforms, ApoB-100 and ApoB-48.. ...

PURPOSE: To test the hypothesis that the accumulation of oxidized phospholipids (OxPL) in the macula is toxic to the retina unless neutralized by a variety of mechanisms, including binding by lipoprotein(a) [Lp(a)], which is composed of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB). METHODS: Human maculas and eyes from two Lp(a) transgenic murine models were subjected to morphologic, ultrastructural, and immunohistochemical analysis. Wild-type Lp(a) mice, which express human apoB-100 and apo(a) that contains oxidized phospholipid, and mutant LBS(-) Lp(a) mice with a defective apo(a) lysine binding site (LBS) for oxidized phospholipid binding, were fed a chow or high-fat diet for 2 to 12 months ...

B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza (EC 2.4.1.38, UDP-galaktoza---glikoprotein galaktoziltransferaza, glikoprotein 4-beta-galaktozil-transferaza, beta-N-acetil-beta1-4-galaktoziltransferaza, tiroid glikoprotein beta-galaktoziltransferaza, glikoprotein beta-galaktoziltransferaza, tiroid galaktoziltransferaza, uridin difosfogalaktoza-glikoprotein galaktoziltransferaza, beta-N-acetilglukozaminil-glikopeptid beta-1,4-galaktoziltransferaza, GalT, UDP-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid beta-1,4-galaktoziltransferaza, UDP-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid 4-beta-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid 4-beta-galaktoziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju. ...

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Barley geneticists are currently using association genetics to identify and fine map traits directly in elite plant breeding material. This has been made possible by the development of a highly parallel SNP assay platform that provides sufficient marker density for genome-wide scans and linkage dise …

In individuals with low Lp[a] levels, there is a corresponding low level of OxPL/apoB, suggesting that in the absence of Lp[a], these OxPLs do not accumulate on plasma apoB-containing lipoproteins other than to a minor degree. A similar situation exists with most animals that we have studied (32, 33). For example, in mice with marked hypercholesterolemia, a situation in which OxPLs recognized by E06 are abundant in the arterial tissues (and probably elsewhere as well), the levels of OxPL/apoB in plasma are very low, and often just at the level of detection of our assay (33). In contrast, Lp[a]-transgenic mice have very high OxPL/apoB levels, even in a C57BL/6 background without obvious atherosclerosis (34). Presumably, this reflects the generation of such OxPLs as a component of normal physiological processes. Lp[a]-transgenic mice express both human apoB-100 and apo[a] and thus can form a true covalent Lp[a] similar to that found in humans (34). Mice expressing high levels of human apoB-100 ...

Background & aim: This study aimed to determine the relationship between lipid and apolipoprotein B-100 (apo B-100) levels in maternal and umbilical cord sera as well as the effects of these components on anthropometric measurements of newborn infants. Methods:This correlational study was performed on 85 appropriate for gestational age (AGA) newborns and their mothers. For analysis, 5 ml of maternal blood and 5 ml of umbilical venous cord blood were obtained during labor and immediately after delivery, respectively. Sera were separated by centrifugation and analyzed on the same day for estimation of lipid profile including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B-100. Also, anthropometric indices of newborn infants were measured and recorded. Pearsons correlation coefficient was used to determine the relationship between variables. Results: There was a positive correlation between

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The significant role of adaptive immunity in atherosclerosis is well established and makes it likely that antigen-presenting DCs are of importance for disease development. This was recently supported by studies that showed that transfer of LDL-loaded DCs into hypercholesterolemic mice accelerated atherosclerosis,31 and that an extended lifespan of DCs affected plaque inflammation and cholesterol metabolism.37 One may surmise that manipulation of DC activity could be used to reduce the autoimmune response to LDL components and ameliorate atherosclerosis.. We now show that DCs can be made tolerogenic to LDL autoimmunity by treating them with IL-10 while loading them with ApoB100. Such ApoB100-loaded tolerogenic DCs inhibited the proliferative and proinflammatory T-cell response to ApoB100 and promoted the development of regulatory T cells. When injected into atherosclerosis-prone huB100tg×Ldlr−/− mice, they induced antiinflammatory activity, reduced immune cell infiltration into lesions, and ...

Stable isotope infusion protocol. Following a 14-h overnight fast, an IV will be inserted into a superficial vein in each forearm, one for infusion and one for sampling. At 7 am, a fasting blood sample will be drawn and the subject will begin to ingest the first of 15 identical small hourly meals, each equivalent to 1/15th of their daily food intake. This will be achieved by giving the patient the drink BOOST (Mead Johnson Nutritionals, Ottawa, On) and, using the Harris Benedict Equation (HBE) to determine the number of total energy requirements. This is based on height, weight, age and activity factors. The subject will have nothing else to eat until the end of the study. At the same time an IV infusion with either heparin plus intralipid or saline or glycerol as indicated above will be started. At 10 am (3 hours after starting the ingestion of hourly feeds), a primed-constant infusion of deuterium-labeled leucine ([D3]L-leucine 98%, Cambridge Isotope Laboratories, MA) will be started, as ...

Folding of the amino-terminal domain of apolipoprotein B initiates microsomal triglyceride transfer protein-dependent lipid transfer to nascent very low density

Phillips, M. L., Pullinger, C., Kroes, I., Kroes, J., Hardman, D. A., Chen, G., Curtiss, L. K., Gutierrez, M. M., Kane, J. P., Schumaker, V. N. A single copy of apolipoprotein b-48 is present on the human chylomicron remnant Journal of Lipid Research 1997 38:1170-1177 PMID:9215545 ...

Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine apolipoprotein B, the major protein in low-density lipids (LDLs) and present in large amounts (approximately 4%) in both very-low-density lipids (VLDLs) and chylomicrons. Apolipoprotein B is found in at least two forms: B-100 (Apo B-100) synthesized in the liver, and B-48 (Apo B-48), probably synthesized in the intestines. Levels of apolipoproteins in plasma are associated with the risk of atherosclerosis and coronary artery diseases.. Entry Terms : Apolipoprotein B Determination Reagents , Reagents, Immunoassay, Lipoprotein, Apolipoprotein B. UMDC code : 19817 ...

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The apolipoprotein (apo) B-100-specific monoclonal antibody MB47 has been widely used in lipoprotein metabolism and atherosclerosis research. When bound to apoB-100 on low density lipoproteins (LDL), antibody MB47 completely blocks the binding of LDL to the LDL receptor. The epitope for antibody MB47 has previously been mapped to the vicinity of apoB-100 amino acid (aa) residue 3500. To map the epitope for antibody MB47 more precisely, we used recombinant bacterial fusion proteins. Antibody MB47 bound strongly to a fusion protein containing apoB-100 aa 3214-3728, but no specific binding was observed to fusion proteins containing aa 3214-3351, 3214-3506, 3351-3506, or a fusion protein containing aa 3214-3351 and 3506-3728. Although antibody MB47 did not bind to aa 3214-3506, it did bind to aa 3214-3510. Further fusion protein studies revealed that antibody MB47 bound to aa 3429-3510, but bound only very weakly to aa 3453-3510, indicating that aa 3429-3453 constitute an important part of the MB47 ...

Apolipoprotein B-100 (apoB-100) appears in three forms in the endoplasmic reticulum of Hep G2 cells: (1) tightly bound to the membrane, ie, not extractable by sodium carbonate. This form is glycosylated but protease sensitive when present in intact microsomes, suggesting that it is only partially translocated to the microsomal lumen; (2) extractable by sodium carbonate and present on low-density lipoprotein-very-low-density lipoprotein (LDL-VLDL)-like particles. This form is glycosylated and secreted into the medium; and (3) extractable by sodium carbonate but having a higher density than the LDL-VLDL-like particles. This form, referred to as Fraction I, is glycosylated and protected against proteases when present in intact microsomal vesicles, indicating that it is completely translocated to the luminal side of the microsomal membrane. Fraction I is not secreted into the medium, but it disappears with time from the cell, suggesting that it is degraded. Oleic acid induced a 2.7-fold increase in ...

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Apolipoprotein (apolipoprotein) je bílkovinná složka lipoproteinů. Apolipoproteinů existuje více druhů a jednotlivé typy se vyskytují v konkrétních lipoproteinech. Apolipoproteiny mají více funkcí, jsou strukturálně důležité, pomáhají transportu lipoproteinových částic, a dokonce mohou fungovat jako koenzymy některých enzymů ...

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Representative light micrographs of H&E- (A-D), PAM- (E-H), and Oil RedO-stained (I, J) kidney sections from 36-week-old human apoB Tg.SHR-cp/cp (A, E, I),

pep:known chromosome:VEGA66:12:7977648:8016835:1 gene:OTTMUSG00000035465 transcript:OTTMUST00000090769 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Apob description:apolipoprotein B ...

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C5b-9小鼠单克隆抗体[aE11](ab66768)可与马, 人, 猪, 猴, 狒狒样本反应并经ELISA, IHC, Flow Cyt, ICC/IF实验严格验证，被7篇文献引用并得到1个独立的用户反馈。

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Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene. MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. Click on genes, proteins and metabolites below to link to respective articles. [[File: [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] ,px,alt=Statin Pathway edit]] The interactive pathway map can be edited at ...

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.[1][2] MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.[2] Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. ...

TY - JOUR. T1 - The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes. AU - Alam, S.. AU - Stolinski, M.. AU - Pentecost, C.. AU - Boroujerdi, Massoud. AU - Jones, R. H.. AU - Sonksen, P. H.. AU - Umpleby, A. M.. PY - 2004. Y1 - 2004. N2 - The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine ...

Microsomal triglyceride transfer protein (MTP) is required for the assembly and cellular secretion of apolipoprotein B (apoB) -containing lipoproteins from the liver and intestine. The secretion pattern of apoB-containing lipoproteins is likely to influence the VLDL and LDL levels in plasma. By initial opportunistic screening for polymorphic sites in the regulatory region of the MTP gene by gene sequencing in 20 healthy male subjects, a common functional G/T polymorphism was detected 493 bp upstream from the transcriptional start point. There was differential binding of unique nuclear proteins at this site, as shown by electrophoretic mobility shift assay. The G variant seemed to bind two or three nuclear proteins that do not bind to the T variant. Expression studies with minimal promoter constructs linked to the chloramphenicol acetyltransferase reporter and transfected into HepG2 cells revealed marked enhancement of transcriptional activity with the T variant. The prevalence of the MTP promoter

oxLDL particles contain MDA-modified peptide fragments derived from degradation of apoB-100.2 Autoantibodies against several such MDA-modified apoB-100 peptides have been found in humans.11 The present studies show that human IgG1 generated against one of these MDA peptide sequences reduces atherosclerosis in apoE−/− mice and that this is associated with reduced accumulation of the corresponding oxLDL-associated epitope and of macrophages in atherosclerotic plaques.. These observations are consistent with earlier studies demonstrating that immunization with oxLDL inhibits the development of atherosclerosis in mice and rabbits.9,10 Activation of this protective immunity is associated with a marked increase in oxLDL-specific IgG. We have recently identified a large number of MDA-modified sequences in apoB-100 that are recognized by antibodies present in human plasma.11 Immunization of apoE−/− mice with some of these peptide sequences resulted in inhibition of atherosclerosis to a similar ...

The atheroprotective effect paralleled an induction of Treg suppression of apoB-100-specific effector T cells and an increase in IL-10+ CD4+ T cells. Therefore, our data suggest that nasal immunization with p210-CTB protects against atherosclerosis by inducing antigen-specific, IL-10+ regulatory Tr1 cells. It is unlikely that atheroprotection involved the immunosuppressive cytokine TGF-β because nasal immunization with p210-CTB also reduced atherosclerosis in mice lacking a functional TGF-β receptor on T cells.. Antigen-specific as well as antigen-independent effects have been reported in studies of Treg.25 Several studies of autoimmune diseases support the regulation model according to which Treg suppresses conventional effector T cells with the same antigen specificity. Other investigators report that Treg exerts major effects on antigen-presenting cells in an antigen-independent manner. Our data clearly show that antigen-specific atheroprotection was paralleled by inhibition of ...

Patton, J G.; Alley, M C.; and Mao, S J., Evaluation of monoclonal antibodies to human plasma low density lipoproteins. A requirement for lipids to maintain antigenic structure. (1982). Subject Strain Bibliography 1982. 75 ...

LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholest

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Fingerprint Dive into the research topics of The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies. Together they form a unique fingerprint. ...

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ヤギ・ポリクローナル抗体 ab20376 交差種: Ms,Rat 適用: RID…Apolipoprotein A I抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。

ヤギ・ポリクローナル抗体 ab7613 交差種: Hu 適用: WB,IP,ELISA…Apolipoprotein A I抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。

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TY - GEN. T1 - Non-truncating APOB gene mutations that cause familial hypobetalipoproteinemia decrease apolipoprotein B-containing lipoprotein secretion in stably transfected McA-RH7777 cells. AU - Burnett, John. AU - Zhong, S.. AU - Hooper, Amanda. AU - Zhao, Y.. AU - Zhang, H.. AU - Barrett, Hugh. AU - Hegele, R.A.. AU - Jiang, Z.G.. AU - Mcknight, C.J.. AU - Van Bockxmeer, Frank. AU - Vance, D.E.. AU - Yao, Z.. PY - 2006. Y1 - 2006. M3 - Conference paper. SN - 00097322. VL - 114. SP - 224. EP - 224. BT - CIRCULATION. T2 - Non-truncating APOB gene mutations that cause familial hypobetalipoproteinemia decrease apolipoprotein B-containing lipoprotein secretion in stably transfected McA-RH7777 cells. Y2 - 1 January 2006. ER - ...

Supply of lipids from the mother is essential for fetal growth and development. In mice, disruption of yolk sac cell secretion of apolipoprotein (apo) B-containing lipoproteins results in embryonic lethality. In humans, the yolk sac is vestigial. Nutritional functions are instead established very early during pregnancy in the placenta. To examine whether the human placenta produces lipoproteins, we examined apoB and microsomal triglyceride transfer protein (MTP) mRNA expression in placental biopsies. ApoB and MTP are mandatory for assembly and secretion of apoB-containing lipoproteins. Both genes were expressed in placenta and microsomal extracts from human placenta contained triglyceride transfer activity, indicating expression of bioactive MTP. To detect lipoprotein secretion, biopsies from term placentas were placed in medium with [(35)S]methionine and [(35)S]cysteine for 3-24 h. Upon sucrose gradient ultracentrifugation of the labeled medium, fractions were analyzed by ...

Abetalipoproteinemia (ABL) is an extremely rare autosomal recessive disorder, which is characterized by defective assembly and secretion of plasma apolipoprotein (apo) B-containing lipoproteins. ABL results from mutations in the gene encoding the microsomal triglyceride transfer protein (MTP). We se …

Clinical Significance: Apolipoprotein A1 is the primary protein associated with HDL cholesterol. Like HDL cholesterol, increased ApoA1 concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B-100 is the primary protein associated with LDL cholesterol and other lipid particles. Like LDL cholesterol, increased ApoB concentrations are associated with increased risk of cardiovascular disease. The ApoB/ApoA1 Ratio correlates with risk of cardiovascular disease.. Limitations: In very rare cases gammopathy, particularly of the monoclonal IgM type (e.g., Waldenstrom macroglobulinemia), may cause unreliable results.. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.. ...

Background Low-density lipoprotein (LDL) particles, the major carriers of cholesterol in the human circulation, have a key role in cholesterol physiology and in the development of atherosclerosis. The most prominent structural components in LDL are the core-forming cholesteryl esters (CE) and the particle-encircling single copy of a huge, non-exchangeable protein, the apolipoprotein B-100 (apoB-100). The shape of native LDL particles and the conformation of native apoB-100 on the particles remain incompletely characterized at the physiological human body temperature (37°C). Methodology/Principal Findings To study native LDL particles, we applied cryo-electron microscopy to calculate 3D reconstructions of LDL particles in their hydrated state. Images of the particles vitrified at 6°C and 37°C resulted in reconstructions at ∼16 Å resolution at both temperatures. 3D variance map analysis revealed rigid and flexible domains of lipids and apoB-100 at both temperatures. The reconstructions ...

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008 ...

|strong|Sheep anti Human Apolipoprotein A1 antibody|/strong| reacts with human apolipoprotein A1 and does not react with other human plasma proteins. In ELISA the following reactivities are observed:|…

In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new...

Man 55 years or older OR woman 65 years or older; Man younger than 55 years OR woman younger than 65 years; Apolipoprotein B:A1 ratio: Q1 (less than 0.633); Apolipoprotein B:A1 ratio: Q2 (0.633-0.792); Apolipoprotein B:A1 ratio: Q3 (0.792-0.983); Apolipoprotein B:A1 ratio: Q4 (>=0.984); Never smoked; Former smoker (last smoked more than 12 months ago); Current or former smoker

Order an Apolipoprotein B Blood Test to evaluate the risk of developing cardiovascular disease and monitor treatment for high cholesterol.

Anti Alzheimers Herbs. Alzheimers Is Genetic Protect Your Future www.alzheimer-herbs.com/ Apolipoprotein alzhei…

APOLB : Collection Container/Tube: Preferred: Serum gel Acceptable: Red top Submission Container/Tube: Plastic vial Specimen Volume: 1 mL Collection Instructions: Centrifuge and aliquot 1 mL of serum.

First Databank™(FDB) Therapeutic Classification provides a means of classifying drugs and drug products for formulary maintenance and reporting.

TABLE-US-00002 TABLE 2 Compo- Compo- Compo- Compo- Compo- nent nent nent nent nent (A) (B) (C) (F) (D) Comparative (A)-1 (B-1) (C)-1 -- (D)-1 Example 1 [100] [3.7] [5.8] [0.6] Example 1 (A)-1 (B-1) (C)-1 (F)-1 (D)-1 [100] [3.7] [5.8] [1.0] [0.6] Example 2 (A)-1 (B-1) (C)-1 (F)-1 (D)-1 [100] [3.7] [5.8] [2.0] [0.6] Example 3 (A)-1 (B-1) (C)-1 (F)-1 (D)-1 [100] [3.7] [5.8] [5.0] [0.6] Example 4 (A)-1 (B-1) (C)-1 (F)-1 (D)-1 [100] [3.7] [5.8] [10.0] [0.6] Example 5 (A)-1 (B-1) (C)-1 (F)-2 (D)-1 [100] [3.7] [5.8] [1.0] [0.6] Example 6 (A)-1 (B-1) (C)-1 (F)-2 (D)-1 [100] [3.7] [5.8] [2.0] [0.6] Example 7 (A)-1 (B-1) (C)-1 (F)-2 (D)-1 [100] [3.7] [5.8] [5.0] [0.6] Example 8 (A)-1 (B-1) (C)-1 (F)-2 (D)-1 [100] [3.7] [5.8] [10.0] [0.6] Example 9 (A)-1 (B-1) (C)-1 (F)-3 (D)-1 [100] [3.7] [5.8] [1.0] [0.6] Example 10 (A)-1 (B-1) (C)-1 (F)-3 (D)-1 [100] [3.7] [5.8] [2.0] [0.6] Example 11 (A)-1 (B-1) (C)-1 (F)-3 (D)-1 [100] [3.7] [5.8] [5.0] [0.6] Example 12 (A)-1 (B-1) (C)-1 (F)-3 (D)-1 [100] [3.7] [5.8] ...

Human plasmas, at a defined DDimer concentration (about 0.6 microgram/ml), as measured with commercially available methods and eespecially the VIDAS-DDimer (Biom�rieux) and the ZYMUTEST DDimer assays, for the quality control of DDimer ELISA assay. Reactive with most of the DDimer assays.

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