Infectious thoracic aortitis is a rare disease, especially since the incidence of syphilis and tuberculosis has dropped in western countries. However, the risk to develop an infectious aortitis and subsequent mycotic aneurysm formation is still present, particularly in case of associated endocarditis, sepsis, and in immunosuppressive disorders. Moreover, the number of surgical and endovascular thoracic aortic repairs is continuously increasing, and infective graft complications are observed more frequently. Several etiopathogenetic factors may play a role in thoracic aortic and prosthetic infections, including hematogenous seeding, local bacterial translocation, and iatrogenous contamination. Also, fistulization of the esophagus or the bronchial tree is commonly associated with these diseases, and it represents a critical event requiring a multidisciplinary management. Knowledge on underlying micro-organisms, antibiotic efficacy, risk factors, and prevention strategies has a key role in the ...
Inflammatory aortic aneurysm (IAA), also known as Inflammatory abdominal aortic aneurysm (IAAA), is a type of abdominal aortic aneurysm (AAA) where the walls of the aneurysm become thick and inflamed. Similar to AAA, IAA occurs in the abdominal region. IAA is closely associated and believed to be a response to and extensive peri-anuerysmal fibrosis, which is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process IAA accounts for 5-10% of aortic aneurysms. IAA is occurs mainly in a population that is on average younger by 10 years than most AAA patients. Some common symptoms of IAA may include back pain, abdominal tenderness, fevers, weight loss or elevated Erythrocyte sedimentation rate (ESR) levels. Corticosteroids and other immunosuppressive drugs have been found to decrease symptoms and the degree of peri-aortic inflammation and fibrosis Inflammatory Aortic Aneurysms occur typically in a younger population compared to the typical Abdominal ...
A 46-year-old man was given a diagnosis of hypertension about 20 years previously. At age 41, aortitis syndrome was diagnosed, with descending thoracic aortic aneurysm and the coarctation of abdominal aorta by CT scan. He then underwent surgery to replace the descending thoracic aortic aneurysm and right axillo-bifemoral bypass. Recently, a thoraco-abdominal aortic aneurysm was pointed out at the distal site of the graft and, he was referred to our institute. We occluded the distal end of the aneurysm using an endoluminal occlusion stent graft. Today, in most cases of aortopathy associated with aortitis syndrome, surgical replacement of the aneurysms and extra-anatomical bypass is performed. An endovascular stent graft treatment combined with extra-anatomical bypass could be useful for various aortic disorders ...
We report the case of a 55-year-old woman with aortitis syndrome. She was admitted to our hospital because of repeated chest pain and syncope. An electrocardiogram and the laboratory data suggested acute myocardial infarction, and coronary angiography showed severe bilateral coronary ostial stenosis. No valvular disease was observed. Aortitis syndrome was suspected because of the stenosis of the brachiocephalic artery in addition to the bilateral coronary ostial stenosis, while the patient did not have elevated C-reactive protein iCRP jand erythrocyte sedimentation rate iESR). Coronary artery bypass grafting was performed, and the patient fs postoperative course was uneventful. However, she again experienced chest pain 9 months after surgery due to aortic regurgitation iAR jand diffuse narrowing change of the left internal thoracic artery graft. Aortic valve replacement and Re-CABG was performed, and the patient was treated with steroid therapy postoperatively. The postoperative course was ...
The sub-renal abnormalities of the lower vena cava (LVC) (left LVC, double LVC) are determined by a deterioration of the alteration process of supra-cardinal veins. Though they are rare, it is necessary to look for them during surgery of abdominal aorta in order to lower the risk of iatrogenic venous injuries. You will find below the description of six cases of sub-renal lower vena cava abnormality (3 double LVC, 3 left LVC) associated with an abdominal aorta aneurism (4 non specific aneurisms, 2 inflammations ones) as well as the diagnostic aspects and the technical issues they cause during the reconstruction of a non specific and inflammation aneurism of the abdominal aorta ...
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
An 86-year-old man presented to our emergency department with fever that he had been experiencing for days. His body temperature was 38.6°C (101.5°F), heart rate was 86 bpm, and blood pressure was 96/50 mm Hg. There was no chest pain, back pain, or abdominal discomfort. Previous medical history included type II diabetes mellitus and prostate cancer under hormonal therapy. Decreased left breathing sound was noted. Initial laboratory studies revealed leukocytosis, elevated C-reactive protein, and acute renal failure. A chest x-ray disclosed a massive amount of left pleural effusion. A thoracocentesis was performed, and the fluid was pus-like exudates. Transverse, sagittal, and coronal views of noncontrast chest computed tomography are shown in Figure A, B, and C, respectively (see also Movies I through III in the online-only Data Supplement). Periaortic foamy air collection was found up to the arch and down to the infrarenal abdominal aorta. Aortic wall invasion was observed in a segment of ...
Introdução. A aortite tuberculosa é uma entidade rara inicialmente descrita por Weigert em 1882.. Report. Um homem de 73 anos, sob controlo imagiológico regular por aneurisma da aorta abdominal de 4cm de diâmetro, foi referenciado ao Departamento por suspeita de ruptura contida. O doente estava assintomático e a Angio-TC evidenciava uma massa inflamatória envolvendo o aneurisma. Durante a cirurgia electiva convencional, infiltração da parede do aneurisma e adenopatias foram identificadas. A análise histológica era compatível com tuberculose. Oito meses após a cirurgia, o doente encontra-se estável e sob terapêutica tuberculostática.. Conclusão. A associação entre tratamento cirúrgico e terapêutica tuberculostática de longa duração é a melhor opção terapêutica para os casos de aortite tuberculosa.. ...
A 20 year old girl had uncontrolled hypertension and absent lower limb pulses. Transoesophageal echocardiography was done. Cross section of the descending aorta at T8 and T9 vertebral level showed an irregular shaped lumen (below left, panel A, arrows; AO, aorta). There was intimal thickening. Long axis imaging showed long segment tight stenosis with the typical rat tail deformity (panel B, arrows) of the lumen. The narrowest diameter was 2 mm while the normal segment above was 11 mm. Non-specific aortoarteritis was diagnosed. Descending aortic injection confirmed the above findings (below right). There was irregular luminal narrowing with rat tail deformity.. ...
6 patients (4 men, 2 women) were included. 2 patients were childrens. Median age was 45 years (9-62 years). The average diagnostic delay between the onset ocular symptoms and immuno histo chemical confirmation was 18 months (2-72 months). Mean follow-up was 32 months (2-72 months). 1 patient (age 9) had a single eye-lid reached, while 5/6 patients also had systemic involvement like parotidis,affected lymph node and tonsil, thyroiditis, aortitis, skin involvement. In 2 cases we found an infraorbital nerve enlargement. All patients had a permanent or transient clinical improvement with corticotherapy.. ...
A aortoarterite sistémica dos adultos é uma doenca inflamatória rara, de etiopatogenia indeterminada, envolvendo a aorta, a artéria pulmonar, a artéria temporal, e os seus ramos. Este artigo analisa o caso de um indivíduo de sexo masculino, indiano, de 71 anos de idade, com sintomatologia sugerindo um processo inflamatório ou uma doença consumptiva. Após a tomografia de emissão positrónica, que mostrou uma absorção anormal e difusa de fluorine-18 fluorodeoxyglucose na aorta torácica e nas artérias subclávias, chegou-se ao diagnóstico. A tomografia de ressonância magnética confirmou o diagnóstico, mostrando ainda uma inflamação do tronco pulmonar. O diagnóstico diferencial entre a arterite de Takayasu e a arterite de células gigantes não era possível, considerando os critérios internacionalmente estabelecidos. O tratamento com prednisolona deu lugar à remissão clínica e laboratorial. A tomografia de emissão positrónica de controle, revelou resultados normais. Os ...
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Sigma-Aldrich offers abstracts and full-text articles by [Hanjun Zhao, Akihiko Ito, Shinya H Kimura, Norikazu Yabuta, Naohiko Sakai, Masahito Ikawa, Masaru Okabe, Yuji Matsuzawa, Shizuya Yamashita, Hiroshi Nojima].
PET was first utilized for imaging aortitis in the late 1990s to help establish a diagnosis in patients with fever of unknown origin. Giant cell arteritis with atypical (extracranial) features and Takayasu arteritis in the early "pre-pulseless" phase was often diagnosed in these patients (14,15). Numerous studies have since demonstrated the utility of PET in giant cell arteritis patients (16) given that temporal artery biopsy is negative in about 15% of typical giant cell arteritis patients and approximately 40% of those with predominantly large vessel involvement (17). Giant cell arteritis has now been established as the most common form of aortitis (18). Furthermore, about 30% of polymyalgia rheumatica (often coexistent with giant cell arteritis) patients have demonstrated large vessel arteritis, including aortitis (19). The sensitivity and specificity of PET in diagnosing giant cell arteritis or polymyalgia rheumatica are reported as 80% and 89%, respectively, in a recent meta-analysis; ...
The authors reported that RPF was idiopathic in 37% of their patients; in the remaining 63%, it was secondary to atherosclerosis (chronic periaortitis and perianeurysmal fibrosis) or recurrent pancreatitis. This description is somewhat unclear. Although there are no standardized classification criteria for the condition, idiopathic RPF is usually included in the spectrum of chronic periaortitis, which also encompasses inflammatory abdominal aortic aneurysms and perianeurysmal RPF (2, 3). Furthermore, it is still unknown whether chronic periaortitis is actually secondary to atherosclerosis because it may also result from an underlying systemic autoimmune disease (3, 4). In addition, we question the appropriateness of including patients with RPF secondary to pancreatitis in this series, which was otherwise composed of cases that were not associated with other diseases ...
Forth-one-year-old male admitted to emergency department with the complaint of abdominal pain. Wall of abdominal aorta seemed thickened on ultrasonography (USG). Abdominal computerized tomographic angiography showed soft tissues surrounding aorta, beginning 9 cmproximal to iliac bifurcation and continuing up to the level of common iliac artery (aortitis? retroperitoneal fibrosis?), and the patient was referred to rheumatology clinic. The patient was hospitalized for further investigations. He did not complain of fever, fatigue, or urinary symptoms. The blood tests revealed the following: Erythrocyte sedimentation rate (ESR) 57 mm/h, CRP 43 mg/L, HGB 14.1 g/dL, WBC count 9800/μL, PLT count 306000/μL, MCV 82.3 fL, creatinine 1.15 mg/dL and ALT 18 U/L. The urinalysis of the patients was normal, and he was negative for ANA, ANCA and ENA. His IgM was 128 mg/dL (46-304), IgG was 2060 mg/dL (751-1560), IgA was 415 mg/dL (82-453), IgG1 was 10700 mg/L (3824-9286), IgG2 was 9070 mg/L (2418-7003), IgG3 ...
TY - JOUR. T1 - Unusual modification of the cabrol shunt for control of hemorrhage in acute type a aortic dissection. AU - Panos, Anthony L.. AU - Suarez, Maria. AU - Salerno, Tomas. AU - Ricci, Marco. PY - 2009/9/1. Y1 - 2009/9/1. N2 - A patient with acute Type A dissection required complex root repair with composite graft. She developed life-threatening hemorrhage at the root of the aorta, which could not be controlled with usual measures. A modification of the original Cabrol shunt allowed for successful control of bleeding.. AB - A patient with acute Type A dissection required complex root repair with composite graft. She developed life-threatening hemorrhage at the root of the aorta, which could not be controlled with usual measures. A modification of the original Cabrol shunt allowed for successful control of bleeding.. UR - http://www.scopus.com/inward/record.url?scp=69949159309&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=69949159309&partnerID=8YFLogxK. U2 - ...
TY - JOUR. T1 - Vancomycin failure in staphylococcal endocarditis. AU - Jackson, Mary Anne. AU - Hicks, Ralph A.. PY - 1987/8. Y1 - 1987/8. UR - http://www.scopus.com/inward/record.url?scp=0023279989&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0023279989&partnerID=8YFLogxK. U2 - 10.1097/00006454-198708000-00011. DO - 10.1097/00006454-198708000-00011. M3 - Article. C2 - 3499592. AN - SCOPUS:0023279989. VL - 6. SP - 750. EP - 752. JO - Pediatric Infectious Disease Journal. JF - Pediatric Infectious Disease Journal. SN - 0891-3668. IS - 8. ER - ...
Sarfati J, Guiochon-Mantel A, Rondard P, Arnulf I, Garcia-Piñero A, Wolczynski S, Brailly-Tabard S, Bidet M, Ramos-Arroyo M, Mathieu M, Lienhardt-Roussie A, Morgan G, Turki Z, Bremont C, Lespinasse J, Du Boullay H, Chabbert-Buffet N, Jacquemont S, Reach G, De Talence N, Tonella P, Conrad B, Despert F, Delobel B, Brue T, Bouvattier C, Cabrol S, Pugeat M, Murat A, Bouchard P, Hardelin JP, Dodé C, Young J. ...
IAA2_WHEAT (P01083 ), IAA3_WHEAT (P10846 ), IAA4_SORBI (P81367 ), IAA5_SORBI (P81368 ), IAA5_WHEAT (P01084 ), IAAA_HORVU (P28041 ), IAAB_HORVU (P32936 ), IAAC1_WHEAT (P16850 ), IAAC2_WHEAT (P16851 ), IAAC3_WHEAT (P17314 ), IAAC_HORVU (P34951 ), IAAD_HORVU (P11643 ), IAAE_HORVU (P01086 ), IAAT_ELECO (P01087 ), IAA_HORVU (P16969 ), IAC16_WHEAT (P16159 ), IAC17_WHEAT (P16852 ), ICIW2_WHEAT (P83207 ), ITRF_MAIZE (P01088 ), RA05_ORYSJ (Q01881 ), RA16_ORYSJ (Q8H4L8 ), RAG1_ORYSJ (Q01883 ), RAG2_ORYSJ (Q01882 ...
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To the Editor:-Fever of unknown origin in patients with giant cell arteritis (GCA) who have neither cephalic symptoms nor histological evidence of temporal arteritis(TA) has, as it corollary, potentially life-threatening aortitis in patients with isolated polymyalgia rheumatica (PMR). In one study, in spite of isolated PMR, the latter characterised by absence of cephalic stigmata as well as by non-diagnostic temporal artery (TA) biopsy, aortitis was, nevertheless, an associated feature, documented by 18-fluorodeoxyglucose positron emission tomography. In other cases only absence of cephalic signs sufficed to characterise isolated PMR, and, in two such instances, aortitis was documented by nuclear magnetic resonance imaging. Diagnostic difficulty is compounded when there is neither cephalic nor PMR symptomatology, as in a 75-year-old woman in whom the only feature of GCA was progressive enlargement of an ascending thoracic aortic aneurysm, necessitating surgical treatment. Histology of the surgical
Chronic periaortitis is a clinico-pathological entity encompassing idiopathic retroperitoneal fibrosis and perianeurysmal retroperitoneal fibrosis. The treatment of this disease is generally based on the use of glucocorticoids, which are often effective. However, prolonged steroid treatments are usually needed to achieve a sustained remission; additionally, patients frequently develop disease relapses following treatment discontinuation, therefore they may be exposed to high cumulative doses of glucocorticoids.. Preliminary data reported in the literature show that methotrexate may be effective in combination with prednisone for retroperitoneal fibrosis. In addition, methotrexate is often used as a steroid-sparing agent in different inflammatory diseases.. The aim of this study is to evaluate whether a treatment with low-dose prednisone plus methotrexate is non-inferior to conventional dose-prednisone in achieving remission in retroperitoneal fibrosis patients. ...
Chronic periaortitis is a clinico-pathological entity encompassing idiopathic retroperitoneal fibrosis and perianeurysmal retroperitoneal fibrosis. The treatment of this disease is generally based on the use of glucocorticoids, which are often effective. However, prolonged steroid treatments are usually needed to achieve a sustained remission; additionally, patients frequently develop disease relapses following treatment discontinuation, therefore they may be exposed to high cumulative doses of glucocorticoids.. Preliminary data reported in the literature show that methotrexate may be effective in combination with prednisone for retroperitoneal fibrosis. In addition, methotrexate is often used as a steroid-sparing agent in different inflammatory diseases.. The aim of this study is to evaluate whether a treatment with low-dose prednisone plus methotrexate is non-inferior to conventional dose-prednisone in achieving remission in retroperitoneal fibrosis patients. ...
Medial degeneration was the most frequent diagnosis in this series of aortic specimens. Medial degeneration was equally common in patients above and below 65 years of age. However, in cases with acute type A aortic dissections, high grade atherosclerosis was the leading histopathological diagnosis in patients older than 65 years. Acute type A aortic dissections seem to have different underlying pathologies in different age groups.. This series represents a one-year volume of an aortic referral center. The intention of this analysis was to correlate histopathological to morphological findings from imaging as well as to raise our intraoperative macroscopic and subjective impressions to a microscopic and objective level.. According to the risk factors a height prevalence of hypertension was observed in all of the patient groups. Especially the TAD group ≥ 65 years of age showed a relatively high rate of hypertension with no clinical diagnosis of connective tissue disease in this group. Generally, ...
Statistiche di Mappa - Arterite di Takayasu - Controlla come questa condizione influisce sulla vita quotidiana delle persone che ne soffrono.
The incidence and etiological classification of valvular diseases were examined on 358 cases from 3,000 consecutive autopsies of more than 60 years of age. The incidence of valvular disease was 11.9% (358 out of 3,000 cases). Mitral stenosis was found in 23 cases (6.4%), of which 21 cases were rheumatic and the remaining 2 were mitral ring calcification (MRC). Mitral regurgitation was observed in 126 cases (35.3%): 69 of papillary muscle dysfunction, 26 of mitral valve prolapse (MVP), 16 of MRC, 9 of ruptured chordae tendineae, 3 of rheumatic and 3 of congenital. Aortic stenosis was noted in 33 cases (9.2%): 27 of calcified, 5 of rheumatic and one of congenital. Aortic regurgitation was found in 169 cases (47.2%): 112 of degenerative, 47 of syphilitic, 7 of rheumatic and 2 of aortitis syndrome. There were 6 cases (1.7%) of tricuspid regurgitation. Etiological classification revealed 6 cases (1.7%) of congenital, 36 (10%) of rheumatic, 49 (13.7%) of syphilitic, 27 (7.5%) of MVP, 69 (19.3%) of ischemic
IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikuliczs disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Read More ...
Understanding the pathogenesis of aortic dissection requires consideration of the inciting event that causes the intimal-medial tear and the propagation of blood within the aortic media. Although various risk factors that predispose the aorta to dissection have been described well, the precise insult that leads to laceration of the intima and media remains unclear.. Historically, the primary causative event that leads to aortic dissection has been extremely controversial. Cystic medial necrosis associated with Marfan disease and other connective tissue disorders was once believed to contribute to aortic medial degeneration, leading to aortic dissection. Larson and Edwards,42 however, demonstrated that only a few of their 161 patients with known aortic dissection exhibited medial degeneration. They found that 158 of these patients had intimal aortic tears at autopsy, which supports the theory initially proposed by Murray and Edwards43 that the intimal tear is the primary event, allowing the blood ...
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression. The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix ...
Mitochondria-associated ER membranes (MAMs) are crucial for lipid transport and synthesis, calcium exchange, and mitochondrial functions, and they also act as signaling platforms. These contact sites also play a critical role in the decision between autophagy and apoptosis with far reaching implications for cell fate. Vascular smooth muscle cell (VSMC) apoptosis accelerates atherogenesis and the progression of advanced lesions, leading to atherosclerotic plaque vulnerability and medial degeneration. Though the successful autophagy of damaged mitochondria promotes VSMC survival against pro-apoptotic atherogenic stressors, it is unknown whether MAMs are involved in VSMC mitophagy processes. Here, we investigated the role of the multifunctional MAM protein phosphofurin acidic cluster sorting protein 2 (PACS-2) in regulating VSMC survival following a challenge by atherogenic lipids. Using high-resolution confocal microscopy and proximity ligation assays, we found an increase in MAM contacts as in PACS-2
We have demonstrated that MMP-8 can degrade and process apolipoA-1 and reduce accordingly the macrophage efflux (Salminen et al. Infl Res -13, FASEB-J -15). At the same time we demonstrated that sub-antimicrobial-doxycycline mediation prevent these processes demonstrating new anti-inflammatory/-proteolytic mechanism for adjunctive doxycycline-medication, inhibition of MMP-8. We have addressed the genetic background (GWAS) related to the elevated serum and salivary MMP-8 (Salminen et al. 2015).
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Performing a temporal artery biopsy is still the easiest way to diagnose giant cell arteritis. However, this biopsy is not always positive, even not in patients with prominent cranial symptoms. In these cases, positron emission tomography with 18-fluorodeoxyglucose as a tracer is a valid alternative. This nuclear technique has demonstrated that involvement of large arteries such as the aorta or the subclavian arteries occurs in 50 to 80% of patients. Ultrasonographic examination of an inflamed temporal artery can demonstrate a halo, corresponding to edema of the intimal layer of the artery. Only in very experienced hands, this non-invasive technique can replace a surgical biopsy. Magnetic resonance imaging and computerized tomographic scanning are not used in the diagnosis of giant cell arteritis, but these techniques can visualize the extent of the disease, e.g. to the aorta with possible aortitis or to a partical artery ...
TY - CHAP. T1 - Uveitis, cogans syndrome, and sarcoidosis. AU - McCallum, Rex. AU - St Clair, E. William. PY - 2007/1/1. Y1 - 2007/1/1. N2 - INTRODUCTION Uveitis, Cogans syndrome (CS), and sarcoidosis are inflammatory disorders in which the predominant manifestations often target the head and neck. However, the head and neck disease may only be a part of a systemic illness with a diverse array of signs and symptoms. The potential for these conditions to be associated with inflammatory disease beyond the head and neck must be taken into account, to ensure appropriate recognition of the full extent of organ system involvement. Uveitis, a type of inflammatory eye disease, may occur in isolation or be a sign of an underlying systemic illness such as ankylosing spondylitis, inflammatory bowel disease, or sarcoidosis. CS is a distinct, albeit rare, clinical entity characterized by inflammatory ocular and inner ear disease; however, it may also be associated with aortitis and systemic vasculitis, ...
In general, Coronary ostial stenosis rarely occurs in patient after the replacement of the aortic valve. It takes place after the aortic valve replacement
To the Editor: Chambers and colleagues (1) reported cure rates of 94% and 33% in episodes of right-sided Staphylococcus aureus endocarditis treated with 2 weeks of nafcillin-tobramycin, and vancomycin-tobramycin, respectively. The enrollment group included 17 patients with endocarditis who were dropped from study analysis when exclusionary criteria developed during treatment. We question the reported cure rates and the pragmatic approach to dropout analysis (2) adopted by Chambers and colleagues.. In order to include these dropouts in the study analysis, one should assume the broadest range of circumstances. In this formulation, all 17 episodes would be cured or not cured. Using ...
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aortic media by conditional disruption of Tsc1, which hyperactivates mTOR complex 1. Consequent SMC hyperplasia led to progressive medial degeneration and TAAD. In addition to diminished contractile and synthetic functions, fate-mapped SMCs displayed increased proteolysis, endocytosis, phagocytosis, and lysosomal clearance of extracellular matrix and apoptotic cells. SMCs acquired a limited repertoire of macrophage markers and functions via biogenesis of degradative organelles through an mTOR/β-catenin/MITF-dependent pathway, but were distinguishable from conventional macrophages by an absence of hematopoietic lineage markers and certain immune effectors even in the context of hyperlipidemia. Similar mTOR activation and induction of a degradative SMC ...
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aortic media by conditional disruption of Tsc1, which hyperactivates mTOR complex 1. Consequent SMC hyperplasia led to progressive medial degeneration and TAAD. In addition to diminished contractile and synthetic functions, fate-mapped SMCs displayed increased proteolysis, endocytosis, phagocytosis, and lysosomal clearance of extracellular matrix and apoptotic cells. SMCs acquired a limited repertoire of macrophage markers and functions via biogenesis of degradative organelles through an mTOR/β-catenin/MITF-dependent pathway, but were distinguishable from conventional macrophages by an absence of hematopoietic lineage markers and certain immune effectors even in the context of hyperlipidemia. Similar mTOR activation and induction of a degradative SMC ...
A 73-year-old man with Hashimotos thyroiditis (HT) suffered from purpura on the lower legs. He was diagnosed with IgG4-related disease (IgG4-RD) with serum IgG4 elevation and dacryo-sialadenitis confirmed histologically. Serum Th2 and Treg cytokines, interleukin 7 (IL7), IL8 and Th2 chemokine levels were elevated, while skewed Th1 balance was seen in fluorescence-activated cell sorting (FACS). Therefore, preferential Th1 balance in HT appeared to be followed by IgG4-RD characterized with Th2 and Treg polarization. The commencement of steroid therapy dramatically exacerbated clinical manifestations including IgG4-RD-associated HT. The measurement of cytokine and chemokine levels as well as FACS analysis in the development of IgG4-RD seemed to be beneficial. In conclusion, an innovative association of HT, IgG4-RD and vasculitis was observed. This report also offers novel diagnostic and therapeutic approaches for IgG4-RD. ...
Maintenance treatment of retroperitoneal fibrosis with steroids is a better option than treatment with tamoxifen as the symptoms & recurrence is reduced.
Learn about Takayasu disease, a chronic inflammation of the aorta. Takayasu disease symptoms include dizziness, headaches, chest pain, and abdominal pain.
On average it takes 44 months from onset of symptoms to diagnose Takayasu arteritis. Because of its rarity and the often subtle physical findings, Takayasu arteritis frequently fails to enter the differential diagnosis for patients with fever of unknown origin (FUO). Thus it is critical to consider Takayasu arteritis in patients under 40 with FUO, aortic regurgitation, hypertension, or absent pulses. Rarely, patients older than 40 years of age meet the criteria for Takayasu arteritis because of a prolonged pre-diagnostic period or late onset of symptoms. In this case, giant cell arteritis may be indistinguishable from Takayasu arteritis; however, initial treatment for both is nearly identical ...
Definition of Clostridium septicum. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Takayasu arteritis is a chronic inflammatory disease of the aorta and its major branches. The disorder is a large vessel vasculitis of unknown origin that most often affects young women in the second and third decades of life (see the image below).
The French urologist Albarran first described retroperitoneal fibrosis (RPF) in 1905, but with Ormonds publication in 1948, the disease became an established clinical entity. (See the image below.
Contact our team of experienced personal injury specialists about retroperitoneal fibrosis claims for compensation. Long established, UK wide legal team
BMJ: British Med J. Some of the arboviruses strike at the extremes of age, with the elderly at greater risk of infection, while mumps and measles peak in the later teenage years. The ameliorating effect of lumbar puncture in viral meningitis. For example, Viral Meningitis may occur as a complication in people with genital herpes. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: A meta-analysis. What tests do health-care professionals use to diagnose oral herpes? Cardiovascular Syphilis Endarteritis of the vasa vasorum of the aorta can lead to aortitis and aneurysm formation.. What is its pathology? Meningococcal disease (either meningitis or septicaemia due to Neissaria meningitidis) can cause some long-term complications. Effect of delayed lumbar punctures on the diagnosis of acute bacterial meningitis in adults. These will prevent serious complications as well as neurological damage. You cannot develop shingles unless you ...
TY - JOUR. T1 - Multiple nonatherosclerotic aneurysms unrelated to a clinical syndrome. AU - Meyer, D. M.. AU - Fry, R. E.. AU - Snyder, W. H.. AU - Fry, W. J.. PY - 1990/1/1. Y1 - 1990/1/1. N2 - Two cases of multiple inflammatory aneurysms in young patients without evidence of autoimmune disease or an aneurysmal syndrome are presented. Neither case showed any clinical or histologic characteristics typical of Ehlers-Danlos syndrome, Marfans syndrome, Takayasus arteritis, or other aneurysmal syndromes. Pathologic findings showed adventitial and medial destruction in both patients; although the first case displayed more adventitial involvement, the second showed greater destruction of the medial elastic laminae. The decision to repair an aneurysm should be tempered by its location, the amount of involvement of the artery with multiple lesions, and the risk to the end-organ if repair is unsuccessful.. AB - Two cases of multiple inflammatory aneurysms in young patients without evidence of ...
This is a 45 year old male patient previously healthy presented with severe abdominal pain, admitted through the ER as a case of AF and signs of acute coronary syndrome. The widened mediation seen in the initial chest x-ray in addition to the si...