TY - JOUR. T1 - Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage. AU - Fuchs, Ralph J.. AU - Lee, W. Anthony. AU - Seubert, Christoph N.. AU - Gelman, Simon. AU - Yeager, Anita. PY - 2003/2. Y1 - 2003/2. N2 - We present a case of descending thoracic aortic aneurysm repair using an endovascular stent graft, complicated by postoperative paraplegia, which was successfully treated by placing a spinal drain. The case highlights the importance of the concept of collateral flow to the spinal cord and of choosing an anesthetic technique that allows immediate postoperative evaluation of lower extremity neurologic function.. AB - We present a case of descending thoracic aortic aneurysm repair using an endovascular stent graft, complicated by postoperative paraplegia, which was successfully treated by placing a spinal drain. The case highlights the importance of the concept of collateral flow to the spinal cord and of choosing an ...
Thoracic aortic aneurysms occur in 3 to 4% of persons older than 65 years. The incidence of thoracic aneurysm is approximately 6 to 10 cases per 100,000 person years with the incidence of thoracic aneurysm rupture occurring in 3.5 per 100,000 persons. The average age of diagnosis is 69 years. The prevalence of thoracic aortic aneurysm is up to 4.2% of the general population without hypertension. Most thoracic aortic aneurysms occur in the ascending aorta or the aortic arch. Aneurysm rupture accounts for 60% of deaths. Degenerative aneurysm associated with advanced age most commonly seen. There is no difference between the incidence in males versus females. Arteriosclerosis is the most common cause of thoracic aneurysm involving the descending aorta and aortic arch. It is most common in older individuals with males affected more than females. The etiology of thoracic aortic aneurysm is dependent on the location of the aneurysm. Ascending thoracic aorta aneurysm can be caused by cystic medial ...
Thoracic endovascular aneurysm repair (TEVAR) is a safe and effective procedure for the treatment of thoracic aortic aneurysms (TAAs).
PURPOSE: To present a technique for renal and visceral revascularization allowing complete endovascular treatment of a ruptured type IV thoracoabdominal aneurysm using devices already stocked in most centers performing endovascular aneurysm repair. TECHNIQUE: Open arterial access is obtained to both common femoral arteries and the left subclavian artery (LSA). Access to the visceral and renal arteries is obtained through separate 8-F sheaths for each visceral and renal branch. Both visceral arteries (celiac trunk and superior mesenteric artery) are accessed through 2 separate sheaths placed into the LSA, and both renal arteries are accessed through 2 separate sheaths placed into the left common femoral artery. Corresponding covered stents are introduced and positioned in the celiac trunk, superior mesenteric artery, and both renal arteries but not deployed. The aortic stent-graft is then introduced and deployed through the right common femoral artery. Once the aneurysm exclusion is completed, ...
The data presented here support the conclusion that heterozygous loss-of-function mutations in LOX, specifically variants that disrupt the catalytic activity or lead to haploinsufficiency, predispose to thoracic aortic aneurysms and acute aortic dissections. Overlapping syndromic features of Marfan syndrome, such as pectus deformities and striae, were reported in family members with LOX variants, but these features were not sufficient to meet diagnostic criteria for Marfan syndrome.13 Thoracic aortic aneurysms in these individuals are either aortic root aneurysms or fusiform aneurysms, involving both the aortic root and ascending aorta. Although mutation carriers died of ascending aortic dissections, there were no reports of aortic dissections with minimal enlargement of the ascending aorta. None of the affected individuals presented with descending thoracic aortic aneurysms or dissections. Interestingly, a bicuspid aortic valve was identified in 3 of 18 individuals with LOX mutations. It is ...
SCVS 2020 Abstracts: Single-stage Hybrid Repair Of A Thoracoabdominal Aortic Aneurysm Complicated By Chronic Type B Aortic Dissection And Kommerells Diverticulum Via Simultaneous Median Sternotomy And Laparotomy
The aorta is the artery that carries oxygen-rich blood away from the heart and on to other arteries that distribute it throughout the body. A thoracic aortic aneurysm occurs when a "balloon" forms in a weakened area of the aorta wall within the chest cavity. The weakened vessel wall is often caused by atherosclerosis. Thoracic aneurysm may occur in three parts of the thoracic aorta: the ascending aorta, the descending aorta or the aortic arch. A minor thoracic aortic aneurysm may have little effect on an individual, but can also be life-threatening and fatal if it bursts and causes severe internal bleeding. Symptoms of thoracic aortic aneurysm may include:. ...
Ascending thoracic aortic aneurysm (ATAA) is defined as a dilatation of the ascending aorta producing a cross sectional diameter more than 1.5 times its normal value; values between 1.1 and 1.5 are considered dilated or ectatic ascending aorta. Normal values have been established by different imaging techniques: echocardiography, computed tomography (CT) and magnetic resonance imaging (MRI)1-3 (table 1). Aneurysmal disease of the aorta is clinically important since, as the diameter of the aorta expands, linear wall stress increases, which in turn directly increases the risk of spontaneous aortic rupture-an event with extremely poor prognosis for the patient. Thoracic aortic aneurysms (TAAs) involve the ascending aorta most commonly (50%), followed by the descending aorta (40%), whereas arch aneurysms (10%) and thoraco-abdominal aneurysms (10%) occur less often. In 25% of patients with ATAA, concomitant abdominal aortic aneurysm is present. Anatomical distinction is important since the aetiology, ...
The main objective for treating thoracic aortic aneurysm is to prevent it from rupturing. Depending on your aneurysms size and location, your options are medical monitoring or surgery.. Medical Monitoring. This will include regular appointments with your doctor along with frequent imaging tests to check the size of your aneurysm and the rate at which it is growing. If you have other heart or arterial conditions, your doctor may prescribe medication to mitigate symptoms.. It is imperative to discontinue all use of tobacco products after being diagnosed with an aortic aneurysm.. Surgery. Surgery is usually the course of action for anyone with an aneurysm larger than about 5 cm (approximately 2.5 inches). The type of surgical procedure you receive depends on the size and location of your aneurysm and your condition.. The most common operations to repair thoracic aortic aneurysms are:. ...
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac ...
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac ...
Detailed information on thoracic aortic aneurysms, including description of a thoracic aortic aneurysm, causes, symptoms, diagnosis, treatment, and full-color anatomical illustrations
Aortic aneurysm repair is surgery to fix a weak and bulging section of the aorta. The aorta is the large blood vessel (artery) that carries blood from the heart through the chest and belly to the rest of the body. The doctor used a man-made tube (called a graft) to replace the weak section of your aorta in your chest.. You can expect the cut (incision) in your chest to be sore for a few weeks. If you have stitches or staples in your incision, the doctor will take these out 1 to 3 weeks after surgery.. You will feel more tired than usual for several weeks after surgery. You may be able to do many of your usual activities after 4 to 6 weeks. But you will probably need 2 to 3 months to fully recover.. Some people find that they feel sad or more emotional than usual while they are recovering after this surgery. This may last for up to 6 weeks after surgery. Talk with your doctor if your sadness continues or if you have concerns about how you are feeling. Treatment and other support can help you feel ...
If you have been diagnosed with thoracic aortic aneurysm, you may be a candidate for endovascular stent grafting. Medtronic stent grafts used to treat over 100,000 patients.
Results: Three of the patients presented with rupture and underwent emergency surgery. Two of the patients had type 1 and one had type 4 thoracoabdominal aortic aneurysm. Mortality occurred in three patients, two of which had undergone surgery due to rupture. One patient developed paraparesis in the postoperative period. Conclusions: Thoracoabdominal aortic aneurysm repair is a high-risk procedure requiring good surgical experience, a multidisciplinary approach, good anesthetic management and a cautious intensive care follow up.. Key words: Aortic aneurysm, thoracic; surgery; treatment outcome ...
Background and Goal of Study: Neurologic deficit is a devastating complication of thoracoabdominal aortic aneurysm repair (TAAAR) and is associated with a significant increase in both, morbidity and mortality. The purpose of this study was to identify predictors of neurologic deficit after TAAAR. Materials and Methods: The subjects for this study comprised 449 consecutive patients
Our experience suggest that nonsurgical repair may be an effective therapeutic option for patients with descending thoracic aortic diseases such as aneurysms, pseudoaneurysms, or dissections.. Aneurysm of descending thoracic aorta was the first thoracic aortic disease to be repaired by a stent graft endovascular procedure. Effectively thoracic aneurysm stent graft treatment has the longest and most established long term results.4-6 In the past, our management of descending thoracic aortic aneurysm was medical unless clinical and instrumental signs of rupture were evident and required immediate surgery. At the present time, indications for stent graft treatment are presence of an uncomplicated aneurysm and history of hypertension with chest discomfort, or signs of compression on surrounding organs, as well as a diameter ,6 cm or expansion ,5 mm per year. However, if a patient is considered to be a candidate for stent graft placement, several major factors have to be taken into account. The most ...
1999 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 17, no 3, 268-270 p.Article in journal (Refereed) Published ...
FLAGSTAFF, Ariz. - July 13, 2017 - W. L. Gore & Associates, Inc. (Gore) today announced the first patient implant of the GORE® TAG® Conformable Thoracic Stent Graft with ACTIVE CONTROL System after receiving CE Mark last month. The first implant was performed by Prof. Dr. med. Giovanni Torsello and Dr. med. Martin Austermann at St. Franziskus Hospital, Munster, Germany.. The thoracic endovascular aortic repair (TEVAR) device is the first to feature a new delivery system that provides the physician with controlled, staged deployment. The system optimizes accuracy, angulation, and apposition to treat etiologies of the descending thoracic aorta including aneurysms, transections, and acute and chronic Type B dissections. The new device will be formally launched in European regions later this year.. The GORE® ACTIVE CONTROL System enhances the exceptional conformability of the stent graft; facilitating the optimized wall apposition that the Conformable GORE® TAG® Device is renowned for even in ...
View details of top thoracoabdominal aortic aneurysm hospitals in Bangalore. Get guidance from medical experts to select best thoracoabdominal aortic aneurysm hospital in Bangalore
OBJECTIVE This study was undertaken to define matrix metalloproteinase (MMP) expression in the anterior and posterior wall of descending thoracic aortic aneurysms (TAAs) and correlate it with specific computed tomography (CT) image sites within the descending thoracic aorta. METHODS Serial CT images of patients with TAAs were compared with age- and gender-matched normal descending thoracic aortas at levels T4-T12. The mean circumference of the TAAs was 153 mm (n = 12) and 148 mm (n = 11) at T8 and T10, respectively, compared with 75 mm (n = 12) and 75 mm (n = 10) in controls (P | .001). Aortic tissue was collected from a separate set of eight patients undergoing descending TAA resection (processed | or =12 hours of excision) and six cadavers (processed | or =24 hours of death). Tissue collected between the intercostals arteries was defined as posterior wall, and directly opposite was the anterior wall. MMP-9 and MMP-2 messenger RNA (mRNA) extracted from aortic tissue was analyzed by quantitative real
Over recent years, an improved consensus has been established regarding diagnosis and management of type B aortic dissection (TBAD). Primary conservative medical treatment with antihypertensive agents in combination with close surveillance seems to be justified in TBAD, until complications such as aneurysmal expansion, rupture, or progression of the initial dissection ... read more occur. Several clinical and radiological predictors of aortic growth in uncomplicated TBAD patients have been identified and can be used to select patients at high-risk for aortic enlargement and rupture during follow-up. Those patients might benefit from closer surveillance or early endovascular intervention. Over recent decades, the management of thoracic aortic pathologies has evolved to include endovascular approaches next to conventional open aortic repair. Currently, thoracic endovascular aortic repair (TEVAR) is the preferred approach for patients presenting with complicated TBAD and other thoracic aortic ...
Surgical resection for thoracic aortic aneurysms is generally recommended when the aneurysms size is 5 centimeters or greater, according to Cleveland Clinic. Some surgeons also calculate the risk of...
Aortic aneurysm, familial thoracic (AAT) 3 (AAT3; MIM 610380), AAT4 (MIM 132900), AAT5 (MIM 608967), AAT6 (MIM 611788), AAT7 (MIM 613780), AAT8 (MIM 615436), AAT9 (MIM 616166), SMAD3 related AAT, TGFB2 related AAT and TGFB3 related AAT are dominantly inherited disorders.. AAT5 and AAT3 have been linked to mutations in the transforming growth factor ß receptor type I and II genes (TGFBR1 and TGFBR2). Patients may have aneurysms of the aorta and other arteries. TGFBR2 mutations are currently estimated to be responsible for 5% of familial thoracic aortic aneurysms and dissections (TAAD).. AAT4, thoracic aortic aneurysm and/or dissection with patent ductus arteriosus is caused by mutations in the myosin heavy chain 11 gene (MYH11). It is important to note that not all individuals with myosin heavy chain mutations appear to have dilated aortas. These individuals, though asymptomatic, display a low aortic compliance and distensibility due to a decrease in the elasticity of the aortic wall.. AAT6 is ...
Aortic aneurysm, familial thoracic (AAT) 3 (AAT3; MIM 610380), AAT4 (MIM 132900), AAT5 (MIM 608967), AAT6 (MIM 611788), AAT7 (MIM 613780), AAT8 (MIM 615436), AAT9 (MIM 616166), SMAD3 related AAT, TGFB2 related AAT and TGFB3 related AAT are dominantly inherited disorders.. AAT5 and AAT3 have been linked to mutations in the transforming growth factor ß receptor type I and II genes (TGFBR1 and TGFBR2). Patients may have aneurysms of the aorta and other arteries. TGFBR2 mutations are currently estimated to be responsible for 5% of familial thoracic aortic aneurysms and dissections (TAAD).. AAT4, thoracic aortic aneurysm and/or dissection with patent ductus arteriosus is caused by mutations in the myosin heavy chain 11 gene (MYH11). It is important to note that not all individuals with myosin heavy chain mutations appear to have dilated aortas. These individuals, though asymptomatic, display a low aortic compliance and distensibility due to a decrease in the elasticity of the aortic wall.. AAT6 is ...
thoracic aortic aneurysms are less common than AAA descending thoracic aorta is the second most common location (after ascending aorta) there is a wide range of causes
Thoracic Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Background Compression of the trachea, bronchi, and pulmonary arteries are complications in patients with large thoracic aortic aneurysms. In this case, we report unexpected cardiopulmonary collapse...
Read about the types of thoracic aortic aneurysms and their common symptoms. UPMC offers various treatments and repair surgeries based on your condition.
The first round began with Crawford illustrating a decided speed advantage over Burns, landing a sizzling left hook to midway through the round, while Burns landed a long right and made good use of his jab. Burns may have taken the first round. He is keeping Crawford off-balance. Crawford is not lighting the world on fire, keeping a low workrate and taking a while to warm up to the task, while the busier Burns takes advantage. Crawford did very little in the second stanza.. Having possibly already fallen into a hole, Crawford continued moving slickly, but not nearly moving his hands fast enough in the third. Burns showed a better workrate, giving the impression of being the harder-working fighter. Crawford may have a strategy in mind, but his subdued approach was somewhat mystifying, despite the rounds being close. Close doesnt get it done in Scotland against a domestic world champ, as we have seen before.. In the 4th, Crawford sprung to life with a prolonged barrage that seemed to have Burns ...
Diseases of the thoracic aorta are increasing in prevalence. In the UK, there has been a steady rise in admissions for thoracic aortic dissection (TAD) from 7.2 to 8.8 per 100 000 population over the last decade.1 At the same time, admissions for thoracic aortic aneurysms (TAA) have increased from 4.4 to 9.0 per 100 000. Thoracic aortic disease is deadly; most patients with TAA are likely to die of a complication attributable to their aneurysm, accounting for up to 47 000 deaths annually in the USA.2 TAD affecting the ascending aorta has a 30-day mortality of 25-50%.3 The increase in numbers of patients presenting with disease of the thoracic aorta is predominantly due to an increase in elderly patients, over 75 years of age.1 This means that the upward trend is likely to continue as the population ages, and that these patients are more likely to suffer from multiple additional comorbid conditions, presenting greater challenges for clinicians. In the face of this increasing problem, our ...
TY - JOUR. T1 - Patologia estesa dellaorta toracica. T2 - Trattamento ibrido con la tecnica del frozen elephant trunk. AU - Di Eusanio, Marco. AU - Armaro, Alessandro. AU - Di Marco, Luca. AU - Pacini, Davide. AU - Pantaleo, Antonio. AU - Di Bartolomeo, Roberto. PY - 2011/6. Y1 - 2011/6. N2 - Background. Aneurysms of the aortic arch extending beyond the origin of the left subclavian artery represent a challenging pathology in aortic surgery and, most commonly, are treated with different surgical, endovascular or hybrid two-staged procedures. In 2006, we initiated an intense surgical program with the frozen elephant trunk procedure that, combining together conventional surgery with endovascular techniques, allows single-stage treatment of patients with extended disease of the thoracic aorta. We here describe our surgical technique and the results with the single-stage frozen elephant trunk procedure. Methods. Between January 2007 and August 2010, 87 patients were treated with the frozen elephant ...
Objective:The aim of this study was to investigate outcomes of patients treated with endovascular repair (ER) with the use of fenestrated and branched stent grafts or open surgery (OS) for thoracoabdominal aortic aneurysm (TAAA) in a current series of patients.Methods:All TAAA patients undergoing re
The probability and prediction of relapses were calculated in 186 patients who finished the 2 year follow-up period. Modification of G alpha with myristate can be recapitulated in E. In the several hypogonadotropic syndromes described to date autosomal and X-linked transmission have been implicated in the inheritance of the hypogonadism. The technique of low flow antegrade selective cerebral perfusion through the right brachial artery may be used for a vast majority of aortic aneurysms and dissections requiring arch repair. Relation of the Bilateral Earlobe Crease to Endothelial Dysfunction.. One patient is awaiting repair, and 1 underwent a cavopulmonary shunt. The reproductive deficits of the middle-aged Per mutant females are comparable with those seen in aged wild-type mice. Step baroreflex response in awake patients undergoing carotid viagra without doctor prescription surgery: time- and frequency-domain analysis. Our experiment assessed whether azithromycin inhibits neutrophil accumulation ...
Thoracal, abdominal and thoracoabdominal aortic aneurysm.: There are gender specific differences in the rate of rupture and endovascular treatment of AAA, TAA a
A thoracic stent graft (20) has a tubular bio-compatible graft material body (22) with a lumen therethrough with a proximal end (26) and a distal end (27). There is a sealing stent (28) at the proximal end of the tubular body with an anchoring device which may be a barb (30) affixed to the sealing stent. A distal attachment stent (34) with barbs (36) can be affixed to and extend from the distal end (27) of the graft material body. Intermediate stents (24) are provided along the length of the body. The thoracic stent graft can be in one or two portions.
Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Fenestrated-branched endovascular repair (FB-EVAR) has been widely applied to treat chronic post-dissection thoracoabdominal aortic aneurysms (TAAAs) with favorable outcomes. A recent multicenter experience indicates that outcomes of FB-EVAR for chronic post-dissection are comparable to degenerative TAAAs. Anatomical and technical pitfalls are different than degenerative aneurysms because of true lumen compression, separate target vessel origin from true or false lumen and possible extension of dissection flaps into the renal and mesenteric vessels. This article focuses on planning and sizing FB-EVAR in patients with chronic post-dissection TAAAs.. ...
NOTE: The records of this soldier indicate that his rank is as a Private (unless promoted) until the latter portion of his career when he is referred to as a Trooper (Tpr); the proper designation for the Armoured Corps.. Pte Crawford was granted an eight-day Leave from January 23 to 31, 1916. February 9, 1916, he was attached to Canadian Cavalry Brigade Headquarters for duty. On February 11, 1916, Pte Crawford was attached to the 1st Indian Cavalry Division (Cav Div) for duty as a Military Mounted Policeman (MMP). February 29, 1916, he returned from training with the 1st Indian Cav Div. April 29, 1916, Pte Crawford was taken-on-strength with the Canadian Cavalry Brigade Headquarters (CCB HQ) on transfer from LSH. The Battle of the Somme waged from July 1 to November 16, 1916; Pte Crawford would have been involved in this action. On September 8, 1916, Pte Crawford was "appointed Acting Lance Corporal (A/L/Cpl) without pay". Also on September 8, 1916, he was attached to the Headquarters of the 2nd ...
The biggest news of Wednesdays practice was rather devastating, especially considering the Cowboys sustained so many injuries on defense last year.. Not even an hour into the first real practice, and theyve already lost a significant player for the year.. Tyrone Crawford suffered a torn Achilles injury and will be out for the rest of the season.. Crawford couldnt put any weight on his left foot and was in obvious pain as he rode in the back of the cart, with his dejected face buried in a towel. Even before he was placed on the cart, Crawford was beating the ground with frustration and then tossed his helmet to the ground in disgust when he made it back to the training room area.. The Cowboys were hoping Crawford would be a key player in the defensive-line rotation as a tackle. Crawford played in all 16 games last year, registering 33 tackles and five quarterback pressures.. Last year, the Cowboys lost linebacker Caleb McSurdy to a torn Achilles and then safety Barry Church in Week 3 of the ...
Dr. Pak responded: Not on its own. Aneurysms tend to grow slowly over time: for abdominal aortic aneurysms, about 10% of their diameter per year, for thoracic aneurysms, maybe slightly less. Risk factors for growth include uncontrolled hypertension and |a href="/topics/smoking" track_data="{
Since its introduction by Michael DeBakey in 1956,1 thoracoabdominal aneurysm (TAA) repair generally presents the most technically challenging and controversial issues in vascular surgery. The surgical repair of TAAs is an undertaking that requires substantial preoperative planning and consideration of a wide array of techniques. Each of these techniques has its champions, and several authors have published comparably good results using widely different methods. In this chapter, the common principles that are applicable to all TAA surgery are described. In addition, most of the surgical techniques currently in use to repair these aneurysms are discussed, with emphasis on those that are preferred at the Johns Hopkins Hospital. ...
Suns procedure of total arch replacement using a tetrafurcated graft with stented elephant trunk implantation: analysis of early outcome in 398 patients with acute type A aortic dissection
Aortic diseases, What is a thoracic aortic aneurysm?,How is a thoracic aortic aneurysm diagnosed?Heart Care For You aim of providing comprehensive cardiac care solutions to the patients for Angioplasty Surgery, Bypass surgery, Cardiac surgery, Valve Surg
The major artery carrying blood from the heart to blood vessels throughout the body, the aorta is about one inch in diameter. From the heart, the thoracic aorta extends upward (ascending aorta) before arching (aortic arch) and extending downward through the chest (descending aorta). Along the way, arteries branching from the thoracic aorta supply oxygen-rich blood to the heart muscle, head and neck, arms, and chest. Thoracic surgeons such as Dr. Raissi specialize in repair and replacement techniques for the ascending aorta, aortic arch and descending aorta - those within the chest cavity. When the aorta passes through the diaphragm and into the abdomen, it becomes known as the abdominal aorta and its arteries supply blood to the abdomen and lower extremities. A localized weakness or bulge in the aorta - an aneurysm - can become life-threatening if it ruptures, and victims often have few, if any, noticeable warning signs. Although prolonged high blood pressure and arterial plaque buildup are ...
BACKGROUND: Plasma low-density lipoprotein (LDL)-cholesterol is implicated in aortic aneurysm (AA) and dissection (AD); however, its role in the pathogenesis of AA and AD, a disease with a high mortality rate, is unknown. The existing animal models such as apolipoprotein E-deficient (Apoe-/-) mice cannot reproduce all the conditions of AA/AD, including elevated LDL-cholesterol levels and spontaneous atheroma formation; therefore, a more reliable in vivo model is required. Here, we analyzed angiotensin II-induced mice with combined deficiency of the LDL receptor and the catalytic component of the apolipoprotein B-edisome complex (Ldlr-/-/Apobec1-/-) to understand AA formation and AD occurrence in relation to plasma lipid composition ...
University of Michigan Thoracic Aortic Program is one of the largest in the country, with low mortality rates for even complex thoracic aortic surgeries.
The most important finding in the SMC-specific expressing S100A12 mice was the dilation of ascending aorta at 16 weeks. At 10 weeks of age, no differences were detected in the dimensions of the ascending aortic lumen by high frequency ultrasound, despite substantial changes in the aortic tissue of transgenic mice at this age. Between 10 and 16 weeks of age, the aortas of SMC-specific S100A12 transgenic mice had a striking increase in maximal diameters compared to their non transgenic littermate controls. It would have been helpful to compliment these ultrasound-defined measurements with ex vivo images and measurements of aortas. Curiously, between 10 and 16 weeks of age was the only interval in which the rate of change of aortic dimensions varied between groups. From 16 to 56 weeks of age, the changes in aortic root diameters between the transgenic and non transgenic mice generally paralleled each other in both males and females. Unfortunately, no characteristics of the aortic tissue were ...
The purpose of this study was to compare two non-contrast 2D techniques with the current contrast-enhanced MRI standard 3D technique for the routine assessment of thoracic aortic pathologies. One hund
Sigma-Aldrich offers abstracts and full-text articles by [Ga-Young Suh, Ramin E Beygui, Dominik Fleischmann, Christopher P Cheng].