TY - JOUR. T1 - Antipruritic effect of curcumin on histamine-induced itching in mice. AU - Lee, Han Kyu. AU - Park, Seok Bum. AU - Chang, Su-Youne. AU - Jung, Sung Jun. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Itching is a common clinical symptom of skin disease that significantly affects a patients quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced itching was blocked by topical application of curcumin in a concentration-dependent manner. In ex-vivo recordings, histamine-induced discharges of peripheral nerves were reduced by the application of curcumin, indicating that curcumin acts directly on peripheral nerves. Additionally, curcumin blocked the ...
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List of elements from ATC D04A: Antipruritics, Topical Use (Antihistamines, Anesthetics) by level of risk according e-lactancia.org
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
... is made from natural plant derivatives which are high in purity, safe and effective. It contains Provitamin B5 which is present in all living tissues and a normal constituent of healthy skin. Essenchi Aquaderm Cream is an excellent skin hydrator, anti-inflammatory and anti-pruritic. It enhances the healing of skin lesions and improves epithelial regeneration. (skin cell and tissue repair)
TY - JOUR. T1 - Five-year malignancy incidence in patients with chronic pruritus. T2 - A population-based cohort study aimed at limiting unnecessary screening practices. AU - Fett, Nicole. AU - Haynes, Kevin. AU - Propert, Kathleen Joy. AU - Margolis, David J.. PY - 2014/4. Y1 - 2014/4. N2 - Background: The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown. Objective: We sought to assess the hazard ratio (HR) of incident overall malignancy and incident malignancy by subtype in patients with chronic pruritus during the 5 years after diagnosis. Methods: A population-based cohort study was performed in the Health Improvement Network. In all, 8744 patients with chronic pruritus were matched with 31,580 patients without chronic pruritus based on sex, age, and practice. Primary outcomes were HR of incident malignancy and HR of malignancy subtypes. Results: The fully adjusted HR for incident malignancy in patients with chronic pruritus was 1.14 (95% confidence ...
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What is hydroxyzine:- Hydroxyzine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of itching, or hives on the skin. Hydroxyzine may be used to treat allergic skin reactions such as hives or contact dermatitis. Since hydroxyzine also reduces activity in the central nervous system, it can be used as a sedative to treat anxiety and tension. It is also used together with other medications given during and after general anesthesia. Hydroxyzine is also used to treat allergic skin reactions such as hives or contact dermatitis. Our Pharmacy Key:- Buy Hydroxyzine Online | Order Hydroxyzine Online | Buy Hydroxyzine Online | Overnight | Fedex | Credit Card | Paypal | COD | Buy Hydroxyzine Online Without Prescription | Buy Hydroxyzine Online With Prescription | Hydroxyzine Overnight Fedex.
The study was approved by the ethic committee of Songklanagarind Hospital in Songkhla, Thailand, and was designed as a randomized, double-blind, placebo-controlled trial. All patients gave their informed consent after receiving written information of the study. Orthopedic patients were invited to participated between September 2009 and August 2010. Patients were considered eligible if they were aged between 15-70 yr, ASA physical status I-III, and were scheduled for lower limb surgery under spinal anesthesia. Patients were excluded if they presented of any following reasons: contraindication for spinal anesthesia, known allergy history to gabapentin, complaint of pruritus before surgery, morbid obesity (BMI , 35), coexisting skin disorder, and any systemic disease associated with pruritus. Patients who had history of seizure attacks, mental illness, chronic headache, or neuropathic pain and were concomitantly using of anticonvulsants, antidepressants, antipsychotics, or antihistamine were also ...
Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects. - Mechanism of Action & Protocol.
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TY - CHAP. T1 - Pruritus. AU - Weisshaar, Elke. AU - Yosipovitch, Gil. PY - 2014/8/11. Y1 - 2014/8/11. N2 - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures and treatment options.. AB - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures ...
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D. Long, N. H. Ballentine, J. G. Marks. Treatment of poison ivy/oak allergic contact dermatitis with an extract of jewelweed. Am. J. Contact. Dermat. 8(3):150-3 1997 PMID 9249283 ...
Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of colon-innervating sensory neurons in mice express, either individually or in combination, the pruritogenic receptors Tgr5 and the Mas-gene-related GPCRs Mrgpra3 and Mrgprc11. Agonists of these receptors activated subsets of colonic sensory neurons and evoked colonic afferent mechanical hypersensitivity via a TRPA1-dependent mechanism. In vivo intracolonic administration of individual TGR5, MrgprA3, or MrgprC11 agonists induced pronounced visceral hypersensitivity to colorectal distension. Coadministration of these agonists as an "itch cocktail" augmented hypersensitivity to colorectal distension and changed mouse behavior. These irritant mechanisms were maintained and enhanced in a model of chronic ...
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If your dog spends a large portion of his time scratching, he may have a condition known as pruritus, or itching, an unpleasant sensation that causes your dog to scratch or bite at himself. It is caused by chemical reactions that occur in the skin and stimulate the nerves, causing the brain to feel the itch. In fact, the act of scratching itself may stimulate these inflammatory reactions in the skin and make the condition worse. Any skin condition that causes inflammation can cause pruritus.. How pruritus affects your dogs health depends on the degree of the pruritus. Mild pruritus may hardly have any effect at all. However, severe pruritus leads to intense scratching, which may result in painful skin lesions that may become infected. Your dog will often whimper or cry out and may have trouble sleeping ...
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This product requires a prescription.Animax is used for dogs and cat. Animax cream or ointment effectively treats skin conditions using 4 kinds of treatment: anti-inflammatory, antipruritic, antifungal and antibacterial.
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Symptoms of Brachioradial pruritus including 9 medical symptoms and signs of Brachioradial pruritus, alternative diagnoses, misdiagnosis, and correct diagnosis for Brachioradial pruritus signs or Brachioradial pruritus symptoms.
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Pruritus is a common presenting symptom in primary care medicine that can prove distressing to the patient and frustrating for the treating doctor. Here is a practical approach to the diagnosis of its causes and its management, including a discussion of some less familiar conditions in which pruritus is a feature.. ...
Pruritus or itching is defined as skin condition being marked with itching and dryness. Here is a rundown of causes, symptoms and prevention of pruritus.
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Pruritus is characterized by intense itching of the skin without the appearance of eruptions. Some cases are of psychological origin and can be treated
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