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TY - JOUR. T1 - Oxygen radical absorbance capacity (ORAC) of cyclodextrin-solubilized flavonoids, resveratrol and astaxanthin as measured with the ORAC-EPR method. AU - Sueishi, Yoshimi. AU - Ishikawa, Misa. AU - Yoshioka, Daisuke. AU - Endoh, Nobuyuki. AU - Oowada, Shigeru. AU - Shimmei, Masashi. AU - Fujii, Hirotada. AU - Kotake, Yashige. PY - 2012/3. Y1 - 2012/3. N2 - Recently, we proposed an oxygen radical absorbance capacity method that directly quantifies the antioxidants scavenging capacity against free radicals and evaluated the radical scavenging abilities for water soluble antioxidant compounds. In this study, we determined the radical scavenging abilities of lipophilic antioxidants which were solubilized by cyclodextrin in water. Commonly employed fluorescence-based method measures the antioxidants protection capability for the fluorescent probe, while we directly quantify free-radical level using electron para- magnetic resonance spin trapping technique. In addition, the spin ...
Oxygen radical absorbance capacity (ORAC) is a method of measuring antioxidant capacities in biological samples in vitro. A wide variety of foods have been tested using this method, with certain spices, berries and legumes rated highly in extensive tables once published by the United States Department of Agriculture (USDA), but withdrawn in 2012 since no correlation between test results and biological activity could be determined, stating that no physiological proof in vivo existed in support of the free-radical theory. Although not all have been unilaterally dismissive, the majority position supports the USDA decision. Alternative measurements include the Folin-Ciocalteu reagent, and the Trolox equivalent antioxidant capacity assay. The assay measures the oxidative degradation of the fluorescent molecule (either beta-phycoerythrin or fluorescein) after being mixed with free radical generators such as azo-initiator compounds. Azo-initiators are considered to produce the peroxyl radical by ...
Background: Patients with end-stage renal disease undergoing hemodialysis (HD) are exposed to oxidative stress, which is associated with an impairment of antioxidant defense and an overproduction of oxidative stress markers. Oxidative stress plays a significant role in the development of inflammation in these patients. Objectives: The high incidence of cardiovascular diseases in HD patients is now well established and the involvement of oxidative stress has been hypothesized in these phenomena. This study focused on a comparison of plasma total antioxidant capacity (TAC) and lipid peroxidation product and evaluated the relationship between them and high-sensitivity C-reactive protein in patients on HD. Subjects and Methods: Plasma (TAC), lipid peroxidation products, malondialdehyde (MDA) as well as high-sensitivity C-reactive protein were determined in 30 patients on HD and in 20 normal controls (NC). Results: TAC and MDA levels were significantly higher in patients on HD than in the control ...
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article{d66ae562-8be9-46fc-bbf8-0060fc9536f8, abstract = {The aim of the study was to investigate whether a supplement of antioxidants to subjects with a high working pace can influence the antioxidant capacity. The study was parallel and double blind with 98 subjects randomised into two groups. One of the groups was given a test drink with antioxidants for 4 weeks (450 ml/day) while the other group took a corresponding amount of placebo drink. The test drink contained: 2 mg beta-carotene/100 ml, 40 mg alpha-tocopherol/100 ml, 80 mg ascorbic acid/100 ml, 2 mg pyridoxine/100 ml, 15 mg magnesium/100 ml, 0.2 mg manganese/100 ml, 1 mg zinc/100 ml, 0.1 mg copper/100 ml and 10 μg selenium/100 ml. Consumption of the test drink for 4 weeks increased the total plasma antioxidant capacity by 7% (ferric reducing ability of plasma method, P<0.05 compared with the placebo group), and the content of selenium and selenoprotein P in serum was raised by 16-17% (P<0.001 compared with the placebo group). No ...
A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in
A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in
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Resistance training is known to promote the generation of reactive oxygen species. Although this can likely upregulate the natural, endogenous antioxidant defense systems, high amounts of reactive oxygen species can cause skeletal muscle damage, fatigue, and impair recovery. To prevent these, antioxidant supplements are commonly consumed along with exercise. Recently, it has been shown that these reactive oxygen species are important for the cellular adaptation process, acting as redox signaling molecules. However, most of the research regarding antioxidant status and antioxidant supplementation with exercise has focused on endurance training. In this review, the authors discuss the evidence for resistance training modulating the antioxidant status. They also highlight the effects of combining antioxidant supplementation with resistance training on training-induced skeletal muscle adaptations. ...
Fresh human milk has a higher antioxidant capacity than infant formula. This result is consistent with the study of Shoji et al,10 who found increased urinary 8-hydroxy-2′-deoxyguanosine excretion in formula fed infants compared with breast fed infants. Schwarz et al11 found similar results by measuring breath ethane concentrations in breast fed and formula fed infants. Although most studies showed that human milk had a higher antioxidant capacity than formula, one study by Alberti-Fidanza et al12 using the oxygen radical absorbance capacity assay, suggested that formula may have higher antioxidant capacity than human milk. The difference in these findings may be due to the different methods used to determine the antioxidant capacity of human milk. An improved oxygen radical absorbance capacity assay has been developed and validated using fluorescein.13,14 Friel et al15 showed that human milk has better antioxidant protection than formulas, perhaps because of the higher iron content of ...
Have you ever heard of antioxidants? Chances are you have heard about antioxidants you can eat. But, did you know there are antioxidants for your skin? The most beneficial antioxidants for your skin are CE ferulic and phloretin. You will be amazed to learn what these two antioxidants can do for your skin.. What is CE ferulic? CE Ferulic contains a combination of 15% vitamin C, 1% vitamin E and 0.5% ferulic acid. This incredible antioxidant protects your skin from free radicals that cause aging.. What are Phloretin antioxidants? This powerful antioxidant combination provides environmental protection for your skin. Phloretin CF contains 10% vitamin C and 0.5% ferulic acid.. Why are antioxidants good for your skin? Antioxidants are known for their ability to improve the appearance of the skin and reduce the signs of aging. Antioxidants protect skin from harmful free radicals.. Where to find antioxidants for your skin? The dermatologist office is the best place for antioxidant treatments. You need ...
TY - JOUR. T1 - Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. AU - Dai, Dao Fu. AU - Chen, Tony. AU - Szeto, Hazel. AU - Nieves-Cintrón, Madeline. AU - Kutyavin, Vassily. AU - Santana, Luis F.. AU - Rabinovitch, Peter S.. PY - 2011/6/28. Y1 - 2011/6/28. N2 - Objectives: We investigated the effect of reducing mitochondrial oxidative stress by the mitochondrial-targeted antioxidant peptide SS-31 in hypertensive cardiomyopathy. Background: Oxidative stress has been implicated in hypertensive cardiovascular diseases. Mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase have been proposed as primary sites of reactive oxygen species (ROS) generation. Methods: The mitochondrial targeted antioxidant peptide SS-31 was used to determine the role of mitochondrial oxidative stress in angiotensin II (Ang)-induced cardiomyopathy as well as in Gαq overexpressing mice with heart failure. Results: Ang induces mitochondrial ROS in neonatal ...
This study was designed to elucidate the effect of ascorbic acid on salivary total antioxidant capacity in smokers. In this single blind crossover clinical trial, the whole unstimulated saliva of 30 smokers, who were randomly divided into two groups, was collected. In the first phase after the saliva collection, one group of patients took 500 mg of vitamin C powder, for 3 weeks. Then, saliva of all patients was collected. After a one-week wash-out period, vitamin C was given to the other group. The collection of saliva was done after 3 weeks. Total antioxidant capacity was measured. Statistic evaluation was performed by Repeated Measured ANOVA, Independent sample t-test and Covariate test. The mean of total antioxidant capacity with and without using vitamin C was 0.511 ± 0.155 (U/mL) and 0.555 ± 0.171 (U/mL), respectively. This variability was not significant (p = 0.605). Oxidative stress from cigarette smoke was not decreased significantly with using vitamin C.
This study will investigate the effect of ENI Patented Whole Grape Extract versus placebo on antioxidant status. The primary objective is to determine antioxidant status by measuring total antioxidant capacity and superoxide dismutase (SOD) in blood and 8-OHdG and 8-isoprostane in first morning void urine samples prior to and after six weeks of supplementation with ENI Patented Whole Grape Extract.. Secondary objectives will include the assessment of oxidized LDL (oxLDL) and safety evaluations:. ...
If your goal is to get a glowing skin tone, end clogged pores, and end acne once and for all, then antioxidants are a goldmine.. Supercharging your bodily antioxidant supplies is the joint most effective strategy for acne. Overall, it is one of the most enjoyable ways to clear acne too. Your near infallible rule is that the more flavoursome the fruit or herb, the heavier and more diverse the antioxidant count.. That said, theres a common perception that plant foods are the only source of antioxidants, which is wrong. A banana, for example, contains only a few antioxidants, like rutin. Meanwhile a slab of beef, not associated with antioxidants in adverts, is drenched in minerals and aids your body in manufacturing its own antioxidants.. The antioxidant content of a food does not totally determine the end result in your bloodstream and skin. To give you an easily consultable list for rapid action, here are 23 foods with strong powers to increase bodily antioxidant levels, and hence strong powers ...
Local resource for antioxidant supplements for athletes in Joplin. Includes detailed information on local businesses that give access to antioxidant supplements such as vitamin C, vitamin E, and beta carotene, as well as advice and content on free radicals and antioxidants.
Local resource for antioxidant supplements for athletes in Lincoln. Includes detailed information on local businesses that give access to antioxidant supplements such as vitamin C, vitamin E, and beta carotene, as well as advice and content on free radicals and antioxidants.
The objective of this study was to determine whether running a 24-h race would cause oxidative damage and changes in the blood antioxidant defense capacity in endurance-trained athletes. Fourteen male amateur runners (mean age 43.0±10.8 y, body weight 64.3±7.2 kg height 171±5 cm, weekly covered distance 81±43 km, training history 8±9 y) who participated in a 24-hr ultra-marathon and volunteered to give blood samples during the race were enrolled for this study. Blood samples were taken before the run, after completing the marathon distance (42.217 km), after 12 h and at the conclusion of the race.The capacity of erythrocyte antioxidant defense system was evaluated by measuring the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), glutathione reductase (GR), concentrations of non-enzymatic antioxidants (uric acid and glutathione-GSH), and selected biomarkers of oxidative stress (i.e., plasma level of malondialdehyde (MDA) and plasma antioxidant capacity ...
If this recipe for Antioxidant Shooters has caught your eye, I have a feeling you are aware that pomegranate juice, strawberries and blueberries are filled with antioxidants. With the addition of beets, this recipe is SUPER high in antioxidants. If you dont have time to cook beets, you can often find them on the salad bar at a high end or gourmet grocery store. What is interesting about beets is not the fact that they are rich in antioxidants, but the unusual mix of antioxidants that they contain. Beets have unique antioxidants since they get their red color primarily from betalain antioxidant pigments (and not primarily from anthocyanins). This combined with being a very good source of the antioxidant manganese and vitamin C, provides antioxidant support in a different way than other antioxidant-rich vegetables.. Have you heard the term but wonder why antioxidants are important? Antioxidants offer a number of health benefits and can help possibly prevent diseases, ranging from cancer to ...
Among the fruits specifically highlighted as beneficial were grapes, which, after consumption resulted in almost double the amount of recommended total antioxidant capacity needed to counteract the deficit associated with consuming 1000 calories of food.. Dr. Ronald L. Prior of the USDAs Arkansas Childrens Nutrition Center, widely recognized as a pioneer of the ORAC (Oxygen Radical Absorbance Capacity) technique for measuring antioxidant capacity in foods, shared his findings regarding the natural state of oxidative stress in the body that results from eating a meal and the ability to counteract it in humans following consumption of certain fruits.. Prior showed that the metabolic process of digesting a meal with no antioxidants -- just fat, carbohydrate and protein -- causes a decline in antioxidant capacity of the blood which creates a temporary state of oxidative stress. This deficit can be prevented by consuming high antioxidant fruits such as grapes, which in this study provided almost ...
Different kinds of antioxidants. Antioxidants are types of nutrients and enzymes that can help promote health and may play a role in reducing your risk of chronic illnesses. They do this by combatting the free radicals produced as a result of oxidation.. Not all forms of antioxidants are the same. In fact, there are different types. Antioxidants can be soluble (i.e. they dissolve) in either water or in fat. Both types of antioxidants are important, as they can both be attacked by free radicals.. Water soluble antioxidants include vitamin C and polyphenols (antioxidants specifically from plants), whereas fat soluble antioxidants include vitamin A, vitamin E, carotenoids and lipoic acid.. Can Oxidative Stress be prevented?. Some of the effects of oxidative stress can be counteracted. Your body is unlikely to produce enough antioxidants to fight all the free radicals, so you can do your bit to support it. Trying to avoid some of the causes of free radicals may be beneficial, as well as eating a ...
Many phytochemicals possess antioxidant and cancer-preventive properties, some putatively through antioxidant response elementCmediated phase II rate of metabolism, entailing mutagen/oxidant quenching. moderate, and none was apparent for glutathione S-transferase pi proteins manifestation. Measurements of reactive air varieties and glutathione/oxidized glutathione percentage demonstrated an antioxidant impact for DMEBP, but no certain effect was discovered for TRES in NHBE cells. Publicity of NHBE cells to H2O2 induced nuclear translocation of nuclear element erythroid 2Crelated element 2, but this translocation had not been inhibited by TRES and DMEBP considerably. These studies also show that strength and low toxicity may for just two potential NQO1-inducing real estate agents align, TRES and DMEBP. screening method of display 800 substances in an all natural items library, this scholarly research offers determined 2,3-dihydroxy-4-methoxy-4-ethoxybenzophenone (derivative, myrtle extract, and ...
Shelf life of cooked ground beef links with no, low, or high concentrations of a blend of natural plant extract antioxidant were compared to evaluate lipid oxidation over time. When no antioxidants were added, samples stored nine days or beyond were more oxidized than the samples with the addition of an antioxidant. No differences in lipid oxidation were observed between 0.13% and 0.20% antioxidant concentrations during similar days of refrigerated storage days. Therefore, the addition of natural antioxidants were effective at reducing oxidative rancidity, regardless the concentration of antioxidant.
Geographically, this report split global into several key Regions, with sales (K MT), revenue (Million USD), market share and growth rate of Water-soluble Antioxidant for these regions, from 2012 to 2022 (forecast), covering. United States. China. Europe. Japan. Southeast Asia. India. Ask for sample copy @ https://www.researchtrades.com/request-sample/1405955 Global Water-soluble Antioxidant market competition by top manufacturers/players, with Water-soluble Antioxidant sales volume, Price (USD/MT), revenue (Million USD) and market share for each manufacturer/player; the top players including. BASF. Chemtura. SONGWON. SI (Albemarle). Double Bond Chemical. CYTEC (SOLVAY). Akzonobel. Clariant. Lanxess. Dow. Sumitomo Chemical. Adeka. Innospec. Kumho Petrochemical. Lubrizol. EVONIK. Addivant. Akrochem. Eastman. On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into. Ascorbic Acid. Tea Polyphenols. Others. Buy a ...
Previous observations have indicated that the red peel areas of grapefruit with high lycopene concentrations were more tolerant to CI than yellow peel areas (Lado et al., 2015a). Because lycopene is a carotene with powerful antioxidant capacity, this study investigated whether the CI tolerance of the lycopene-accumulating rind of grapefruit may be due to an enhancement of the enzymatic and/or nonenzymatic antioxidant systems. Total antioxidant capacity, antioxidant metabolite (GSH and AsA) contents, and antioxidant enzyme (GR [glutathione reductase], ascorbate peroxidase [APX], catalase [CAT] and superoxide dismutase [SOD]) activity and gene expression were measured in the peel of Star Ruby grapefruit with contrasting CI tolerance during storage at 2 C for up to 58 d. The peel of CI-tolerant fruit exhibited a lower lipid peroxidation level (MDA content). The hydrogen peroxide concentration was similar after 3 weeks of storage, when the differences in chilling damage between sensitive and ...
The antioxidant capacity and the phenolic content of hydroalcoholic macerations from leaves, inflorescences, stems and roots of species of the genus Pluchea were also compared. Leaf extracts followed by inflorescence extracts showed the highest values of antioxidant capacity. The species P. carolinensis was used as a model to evaluate the antioxidant capacity in two locations and two phenological stages and also for monitoring the antioxidant capacity over some months. Natural adult specimens presented a higher phenolic content, as well as higher antioxidant capacity than young and cultivated specimens. Maximal antioxidant capacity and concentrations in phenolics were recorded in January, September and December; over the blooming stage (March), the antioxidant capacity was minimal. Two different solvents of extraction and two methods were also screened for extracting the maximal concentrations in antioxidants. Hydroalcoholic extractions showed higher antioxidant capacity than ethanolic ones. ...
On the other hand, vitamin C did not have an effect on mortality and the antioxidant mineral selenium was associated with a nine per cent decrease in all-cause mortality. "We could find no evidence to support taking antioxidant supplements to reduce the risk of dying earlier in healthy people or patients with various diseases,"​ said Goran Bjelakovic from the Copenhagen Trial Unit at the Copenhagen University Hospital in Denmark. A republishing of last years antioxidant meta-analysis in the prestigious Cochrane Systematic Review​ today looks set to refocus attention on the efficacy of antioxidant supplements, and raise questions over their safety. The meta-analysis was originally published in the Journal of the American Medical Association​ (2007, Vol. 297, pp. 842-857) last year and attracted criticism from both inside and outside of the dietary supplements industry. The authors admit that this report contained errors and corrections were subsequently published in JAMA​ (2008, Vol. ...
Irwin Naturals Anti-Aging Antioxidants 60 Soft-gels Anti-Aging Antioxidants Directions: Take two soft-gels daily with a meal and a full glass of water. The Free Radical Theory of Aging Free radicals are a major contributor to aging. The free radical theory of aging states that the inborn process of aging is caused by the accumulation of free radical damage inside the body. This theory is supported by countless studies and suggests that antioxidants can help neutralize the effects of natural aging.* Boost Your Antioxidant Defense Systems! Anti-Aging Antioxidants is a simple yet powerful way to boost your daily antioxidant intake. This product supplies a broad spectrum of antioxidant-active compounds to protect your body from the harmful effects of free radicals.* Anti-Aging Antioxidants can be used daily or as needed to help fill the nutritional gaps in your diet. Supplement Facts Serving Size 2 Liquid Soft Gels Servings Per Container 30 Vitamin C as Ascorbic Acid 500mg 833%
You have likely heard the term “antioxidant supplements,” but do you know the role that antioxidants play in preventing cardiovascular disease? In fact, according to proponents of antioxidant supplements, antioxidants cannot only prevent cardiovascular disease, but also reverse the damage that often leads to numerous...
Seventytwo Indian barley varieties were screened for their antioxidant activity for 2 years using two antiradical systems Differences in the levels of antioxidant activity in 2 years were obtained but the genotypic differences still remained and a 2fold variability was observed in the antioxidant activity Yeartoyear differences were also obtained when the selected varieties were analyzed for their free and bound phenolic contents Evaluation of the antioxidant activity and phenolic content in the five varieties grown at six different locations revealed that the antioxidant activity and the free phenolics were more influenced by the genotype whereas the bound and the total phenolics were most influenced by the environment After malting no significant changes were observed in the antioxidant activity however a 2fold increase was observed in the total phenolic content which was mainly due to the increase in the level of free phenolics after ...
1. The oxidation of low-density lipoprotein (LDL) is believed to play a central role in atherogenesis. We have compared the effect of antioxidant vitamins and high-density lipoprotein (HDL) on the Cu(2+)-catalysed oxidation of LDL. 2. Antioxidant vitamin supplementation significantly reduced conjugated diene formation but did not affect the formation of lipid peroxides. 3. Conversely, HDL did not affect conjugated diene formation but inhibited the formation of lipid peroxides by up to 90%. 4. The inhibition by HDL of lipid peroxide formation in oxidized LDL was dependent on the concentration of HDL and was not due to HDL chelating Cu2+. 5. Large interindividual variations in the inhibition of lipid peroxide formation by autologous HDL were evident, which were related to the rate of lipid peroxide generation in the LDL. 6. We conclude that HDL is a powerful antioxidant or more probably inhibitor of LDL oxidation in vitro and may play an important role in vivo in preventing atherosclerosis by ...
Hydrogen atom transfer (HAT) is the mechanism by which the vast majority of radical-trapping antioxidants (RTAs), such as hindered phenols, inhibit autoxidation. As such, at least one weak O-H bond is the key structural feature which underlies the reactivity of phenolic RTAs. We recently observed that quinone methi 2020 Chemical Science HOT Article Collection 2020 ChemSci Pick of the Week Collection
Youve seen or heard the term antioxidant before and you feel like its something you should have in your food, right? Right, but you probably dont know what antioxidants actually are and why you need them. I know that was the case for me.. To understand what antioxidants are, you must first know what a free radical is. Free radicals are naturally occurring substances in our bodies that attack the fats, protein and DNA in our cells, causing us to age quickly and can even cause diseases. Antioxidants are the compounds found in some foods that help to neutralize the free radicals in our bodies. The best sources of antioxidants are fruits and vegetables but they are also found in green tea, black tea, red wine and dark chocolate (yum!). According to experts, the presence of color indicates that there is a specific antioxidant in that food.. Now do you understand why we need them? I do! To get a healthy dose of antioxidants in your diet, try eating more of these foods.. Tomatoes ...
BACKGROUND & AIMS: Chronic inflammation impairs recovery among the 1.6 million people who suffer from hip fracture annually. Vitamin E and the carotenoids are two classes of dietary antioxidants with profound anti-inflammatory effects, and the goal of this study was to assess whether higher post-fracture concentrations of these antioxidants were associated with lower levels of interleukin 6 (IL-6) and the soluble receptor for tumor necrosis factor-alpha (sTNF-αR1), two common markers of inflammation. METHODS: Serum concentrations of the dietary antioxidants and inflammatory markers were assessed at baseline and 2, 6, and 12 month follow-up visits among 148 hip fracture patients from The Baltimore Hip Studies. Generalized estimating equations modeled the relationship between baseline and time-varying antioxidant concentrations and inflammatory markers. RESULTS: Higher post-fracture concentrations of vitamin E and the carotenoids were associated with lower levels of inflammatory markers. ...
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Extensive evidence has demonstrated that many antioxidants such as vitamin C, vitamin E, carotenoids and polyphenols have protective effects in preventing cardiovascular disease (CVD), a chronic disease that is mediated by oxidative stress and inflammation. This review focuses on evidence from prospective cohort studies and clinical trials in regard to the associations between plasma/dietary antioxidants and cardiovascular events. Long-term, large-scale, population-based cohort studies have found that higher levels of serum albumin, bilirubin, glutathione, vitamin E, vitamin C, and carotenoids were associated with a lower risk of CVD. Evidence from the cohort studies in regard to dietary antioxidants also supported the protective effects of dietary vitamin E, vitamin C, carotenoids, and polyphenols on CVD risk. However, results from large randomized controlled trials did not support long-term use of single antioxidant supplements for CVD prevention due to their null or even adverse effects on major
Natures Cellular Protection. Research has shown that many degenerative diseases are the direct result of free radical damage in the body. Free radicals are considered a major component in aging and disease progression. The destruction of healthy cells may easily be avoided by adding powerful antioxidant nutrients to your daily diet.. The antioxidant combination in Radical Fruits™ has potent immune-enhancing properties. An extensive ORAC analysis (Oxygen Radical Absorbance Capacity) performed at Tufts University in Boston, showed high scores in the ability of these fruit extracts to significantly protect cells and their components from oxidative damage. They were also shown to help slow the processes associated with aging in both body and brain function. High ORAC foods have been found to raise the antioxidant capacity of human blood 10-25%, helping to increase learning ability and prevent the loss of long-term memory.. Due to their superior bio-availability, the concentrated fruit extracts in ...
Mitochondrial antioxidant genes are major regulators of oxidative stress in the vasculature. Previous data has shown that reducing antioxidant capacity accelerates atherosclerotic plaque size, however, it is unclear whether reducing mitochondrial antioxidant capacity alters plaque composition. Therefore, we tested the hypothesis that reductions of mitochondrial antioxidant capacity will increase osteogenic markers and intimal plaque calcification in aorta from hypercholesterolemic mice. We used Ldlr-/-ApoB100/100 (LA) mice that were either wild-type (LA-MnSOD+/+) or heterozygous (LA-MnSOD+/-) for manganese superoxide dismutase that were fed a Western Diet (TD88137) for 3 or 6 months. Changes in changes gene expression were assessed in aortic arch using qRT-PCR, plaque calcium levels were examined using histological evaluation from aortic cryosections, and endothelial function was measured using isolated organ bath chambers (ex vivo). While expression of SP7 (an osteogenic transcription factor) ...
... By Nathan Gray, 25-Jul-2011 Related topics: Botanicals, Research, Antioxidants, carotenoids, Phytochemicals, plant extracts A novel and powerful natural antioxidant, which is it is 4.5 times more potent than vitamin E and 10 times more potent than vitamin C, has been discovered in tomato plants. The powerful antioxidant is reported to be produced by certain tomatoes when under stressful conditions The powerful antioxidant is
Clove is considered to be the best source of natural antioxidants. Purple cabbage, on the other hand, is the most affordable option.. Kale is bursting with beta-carotene, vitamin C, and similar antioxidants. It also has large amounts of other vitamins and minerals.. If artichoke is on the menu due to its antioxidant content, eat the whole vegetable. The leaves are even healthier than the heart.. Oregano also offers anti-cancer benefits and can be easily grown in a small garden. Other antioxidant-rich spices include allspice, cilantro, and cinnamon.. Peppermint can be turned into a herbal tea. The resulting hot drink is both refreshing and will replenish antioxidant levels.. Among the various berries, blueberries boast the greatest amount of antioxidants. Goji berries give it a run for its money, but the exotic berries also cost way more.. Dehydrated apples, apricots, and plums have more antioxidants than their fresh equivalents. Pick unsweetened ones as the fruits are quite sugary ...
Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some trials show that antioxidants actually increase cancer risk and a study in mice showed that antioxidants accelerate the progression of primary lung tumors. However, little is known about the impact of antioxidant supplementation on the progression of other types of cancer, including malignant melanoma. We show that administration of N-acetylcysteine (NAC) increases lymph node metastases in an endogenous mouse model of malignant melanoma but has no impact on the number and size of primary tumors. Similarly, NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between reduced and oxidized glutathione in melanoma cells and in lymph node metastases, and the increased migration depended on ...
AntiOxidant Formula Protection against free radicals Supplementation with antioxidants such as vitamins C and E has been growing rapidly in the past few years as research on harmful free radicals intensifies. Free radicals are atoms, ions, or molecules with one or more unpaired electrons that bind to and destroy cellular compounds. Dietary antioxidants disarm free radicals through a number of different mechanisms. Foremost, they bind to the free electrons, pairing up with them, creating an innocuous cellular compound that the body can eliminate as waste. The antioxidants in this formula also support and enhance the bodys natural defense mechanisms against free radicals: the enzymes superoxide dismutase, catalase, and glutathione peroxidase. Recent research points to the fact that a synergistic combination of antioxidants is more effective than the total effect of each antioxidant taken alone. AntiOxidant Formula offers a synergistic, broad spectrum of antioxidants designed to protect
A number of analytical methods exist for the evaluation of oxidative stress. Some of these directly measure the accumulation of oxidizing species or of oxidized products, while other methods measure the defence capacity of the organism against oxidation, which is referred to as the specific or the total antioxidant capacity (TAC). Amongst these TAC methods, TEAC (Trolox Equivalent Antioxidant Capacity) assays which involve the use of radicals of compounds such as N,N-dimethyl-p-phenylenediamine (DMPD) or 2,2’-azinobis(3- ethylbenzothiazoline-6-sulphonic acid) (ABTS), have attracted the attention of biochemists and analysts due to their operational simplicity. These methods are based upon the spectrophotometric measurement of the antioxidant activity of body fluids, herbal extracts, fruits, vegetables and other food samples and have certain limitations with regard to their application range, stability and environmental fate. In the present study we have improved upon the ...
It is difficult to evaluate the physiological effects of specific natural phenolic antioxidants, since such a large number of individual compounds may occur even in a single food and their fate in vivo cannot be measured.[1][5]. Other more detailed chemical research has elucidated the difficulty of isolating individual phenolics. Because significant variation in phenolic content occurs among various brands of tea, there are possible[8] inconsistencies among epidemiological studies implying beneficial health effects of phenolic antioxidants of green tea blends. The Oxygen Radical Absorbance Capacity (ORAC) test is a laboratory indicator of antioxidant potential in foods and dietary supplements. However, ORAC results cannot be confirmed to be physiologically applicable and have been designated as unreliable.[3][9]. ...
Since evidence became available that free radicals were involved in mechanisms for the development of major diseases, including cardiovascular disease and cancer, there has been considerable research into the properties of natural dietary antioxidants. However, it has become clear that dietary antioxidants can only have beneficial effects in vivo by radical scavenging or effects on redox potential if they are present in tissues or bodily fluids at sufficient concentrations. For many dietary components, absorption is limited or metabolism into derivatives reduces the antioxidant capacity. For many dietary phytochemicals, direct antioxidant effects may be less important for health than other effects including effects on cell signalling or gene expression in vivo.
Oxidative stress occurs when oxygen free-radicals outnumber antioxidants in the body, leading to inflammation that damages cell proteins, fats and DNA. In coronary artery disease (CAD), blood vessels thicken and narrow, and doctors in one study said oxidative stress and inflammation play a central role. In the study, 51 people with advanced CAD took 60 mg of CoQ10 per day, 150 mg per day or a placebo. Coenzyme Q10, or ubiquinone, is a powerful antioxidant that helps produce energy in every cell in the body.. After 12 weeks, while there was no significant change in the placebo or 60 mg groups, those who took 150 mg of CoQ10 had 29 percent lower levels of oxidative stress and a large increase in protective antioxidant enzyme activity.. Doctors concluded CoQ10 may promote rapid and sustainable antioxidation in CAD.. ...
Background This study was aimed to examine circadian variations of hepatic antioxidant components, including the Nrf2- pathway, the glutathione (GSH) system, antioxidant enzymes and metallothionein in mouse liver. Methods and Results Adult mice were housed in light- and temperature-controlled facilities for 2 weeks, and livers were collected every 4 h during the 24 h period. Total RNA was isolated, purified, and subjected to real-time RT-PCR analysis. Hepatic mRNA levels of Nrf2, Keap1, Nqo1 and Gclc were higher in the light-phase than the dark-phase, and were female-predominant. Hepatic GSH presented marked circadian fluctuations, along with glutathione S-transferases (GST-α1, GST-µ, GST-π) and glutathione peroxidase (GPx1). The expressions of GPx1, GST-µ and GST-π mRNA were also higher in females. Antioxidant enzymes Cu/Zn superoxide dismutase (Sod1), catalase (CAT), cyclooxygenase-2 (Cox-2) and heme oxygenase-1 (Ho-1) showed circadian rhythms, with higher expressions of Cox-2 and CAT in
Nowadays the usage of antioxidants is rather popular, because many people say that they take them. What is the reason of such popularity? In past times, antioxidants were available only for rich people who want ted to maintain young and healthy look, Today everyone is able to take antioxidants, which slow down the process of aging. Antioxidants also protect us prom different pollutants that are in atmosphere.. Today more and more people want to save their look and good health for a long time and that?s why they begin to take antioxidant supplements. Today it is not fashionable to look old; it is modern to look young as long as possible. In order to safe young look, many people prefer plastic surgery instead of antioxidant supplements or cosmetic things. But taking antioxidants is much better because this way is also effective, useful, and safe in comparison with surgery ...
Antioxidants have many known health benefits. Browse iHerbs selection of natural antioxidant supplements & vitamins to find the right products for your diet.