A study to evaluate the efficacy of lenalidomide as maintenance therapy after completion of first-line combination chemotherapy in patients with mantle cell lymphoma (MCL) who are not candidates for transplantation and have achieved partial response (PR) or complete response (CR).. This study was prematurely terminated by the sponsor in light of new unpublished data that rendered the current design of the study no longer clinically relevant. A study design with the control arm of no active treatment was no longer appropriate. The termination of the trial was not based on any safety concerns in the study. ...
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A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy. The majority of drugs used in cancer chemotherapy are cytostatic, many via cytotoxicity. A fundamental philosophy of medical oncology, including combination chemotherapy, is that different drugs work through different mechanisms, and that the results of using multiple drugs will be synergistic to some extent. Because they have different dose-limiting adverse effects, they can be given together at full doses in chemotherapy regimens.[1]. The first successful combination chemotherapy was MOPP, introduced in 1963 for lymphomas. The term induction regimen refers to a chemotherapy regimen used for the initial treatment of a disease. A maintenance regimen refers to the ongoing use of chemotherapy to reduce the chances of a cancer ...
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating acute lymphoblastic leukemia.. PURPOSE: This randomized clinical trial is studying the side effects of two combination chemotherapy regimens and to see how well they work in treating children with newly diagnosed acute lymphoblastic leukemia. ...
A multi-agent system (M.A.S.) is a computerized system composed of multiple interacting intelligent agents within an environment. Multi-agent systems can be used to solve problems that are difficult or impossible for an individual agent or a monolithic system to solve. Intelligence may include some methodic, functional, procedural approach, algorithmic search or reinforcement learning. Although there is considerable overlap, a multi-agent system is not always the same as an agent-based model (ABM). The goal of an ABM is to search for explanatory insight into the collective behavior of agents (which dont necessarily need to be intelligent) obeying simple rules, typically in natural systems, rather than in solving specific practical or engineering problems. The terminology of ABM tends to be used more often in the sciences, and MAS in engineering and technology.[1] Topics where multi-agent systems research may deliver an appropriate approach include online trading,[2] disaster response,[3][4] ...
Giving chemotherapy drugs every 2 weeks instead of the usual every 3 weeks reduces the risk of breast cancer recurrence and death, according to research published in The Lancet on 7 February 2019.. The study, undertaken by the Early Breast Cancer Trialists Collaborative Group (EBCTCG) analysed data from over 37,000 women with early (operable) breast cancer who had taken part in 26 randomised trials from across the world that compared dose-intense chemotherapy with standard schedule chemotherapy.. The analysis aimed to find out whether increasing the dose intensity of chemotherapy (the amount of drug delivered per unit time), was more effective at lowering breast cancer recurrence and death rates than standard schedule chemotherapy regimens. One way to increase dose intensity was to use the same chemotherapy agents at the same doses but administer treatment every two weeks instead of every three weeks. The average weekly dose is therefore 50% higher with 2-weekly treatment than with the ...
This study looks at how well how well pazopanib hydrochloride, (targeted chemotherapy), combination chemotherapy, and radiation therapy work compared to radiation therapy alone, or in combination with pazopanib hydrochloride or combination chemotherapy in treating patients with newly diagnosed non-rhabdomyosarcoma soft tissue sarcomas that can be removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as ifosfamide and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether radiation therapy works better when given with or without combination chemotherapy and/or pazopanib hydrochloride in treating patients with non-rhabdomyosarcoma soft tissue sarcomas. ...
Chemotherapy is medication delivered to the body to eliminate cancer cells or greatly reduce their effect. It targets cells that divide rapidly, a characteristic of most cancer cells.. Chemotherapy, often used to support and enhance other cancer treatment modalaties, interferes with the division and reproduction of cells. If a cancer cell cannot reproduce, it eventually dies without another cell to replace it. Chemotherapy is usually administered orally or intravenously. Some types of chemotherapy are delivered daily over a prescribed period, while others are given weekly. Similarly, some chemotherapy infusion sessions last only a few minutes, while others take a full day.. Recent advances in chemotherapy treatment mean patients may not experience some of the common side effects previously associated with chemotherapy. For instance, not all treatments result in hair loss, weight gain, or nausea. Side effects of chemotherapy depend on the type and dose of chemotherapy received. Your physician may ...
Abstract Background: For patients with metastatic pancreatic adenocarcinoma, there are no approved or established treatments beyond the 2nd line. A Phase Ib study of fractionated radioimmunotherapy was undertaken in this setting, administering 90Y-clivatuzumab tetraxetan (yttrium-90-radiolabelled humanised antibody targeting pancreatic adenocarcinoma mucin) with or without low radiosensitising doses of gemcitabine.
Sam and I keep hearing the same excellent questions about chemotherapy and his schedule. Up until a few weeks ago, we never understood how the whole chemotherapy thing worked. Our heads spun wildly at our first meeting with our oncologist who came up with the chemotherapy treatment and schedule. I was left staring blankly at Kates rigorous note-taking. We refer to her unbelievably thorough notes frequently.. Sam and I recently talked about our chemotherapy knowledge prior to the last several weeks. Even though we have known several people who have received chemotherapy, we had never thought about all the details. The only thing we knew was that chemotherapy was usually associated with hair loss. Heres a bit of the education weve gotten over the last few weeks.. Chemotherapy is a type of cancer treatment that uses drugs to destroy cancer cells. It works by stopping or slowing the growth of cancer cells, which grow and divide quickly. While its busy with the bad cells, it also harms healthy ...
Keytruda established itself as the new standard for first-line treatment of metastatic non-small cell lung cancer (NSCLC) - and also finally overtook its main rival, BMS Opdivo in revenues in Q2 of last year.. This success rests on numerous trials, but its biggest bullseyes last year were as a first-line combination with standard chemotherapy regimens in non-squamous NSCLC (KEYNOTE-189, which confirmed its efficacy after conditional approval via another study) and in squamous (KEYNOTE-407) NSCLC as compared to these existing regimens alone.. These indications have now both been approved in the US (with Europe expected to clear the squamous use soon) and are set to be key drivers for Keytrudas growth in 2019.. The only drug that has any realistic chance of challenging Keytruda in NSCLC is Roches Tecentriq. The company is exploring its use in a variety of double and triple combinations.. In December the FDA approved its use in combination with Avastin and chemotherapy in non-squamous NSCLC ...
The goal of this clinical research study is to find out if switching from a standard chemotherapy combination to a more intensive experimental combination, based on imaging scans, will improve response to treatment in patients with Hodgkin lymphoma (HL). The safety of this experimental chemotherapy combination will also be studied.
Neoadjuvant chemotherapy (NCRT) is superior to neoadjuvant multi-agent chemotherapy (NMAC) for the treatment of stage II or III rectal adenocarcinoma.
The present study demonstrated the following three important clinical observations. First, the OS of the chemotherapy group was better than that of the BSC group in elderly patients with poor PS. Second, the number of treatment cycles had a larger impact on the survival benefit of chemotherapy than the decision/selection of either single-agent therapy or carboplatin-doublet therapy. Third, hypoalbuminemia was not only the risk factor for early termination of chemotherapy, but also the independent prognostic factor in the chemotherapy group.. The clinician-estimated PS is the most common method to evaluate physiologic reserve and functional status in NSCLC patients, and it is used to assess a patients tolerability against chemotherapy. In previous clinical trials conducted for elderly, advanced NSCLC patients, such as the ELVIS and IFCT-0501 trials [3, 4, 7], 20-30% of patients had a PS of 2, whereas almost no data were available for patients with PS ≥ 3. Given this, there is a general ...
BACKGROUND: The molecular characteristics associated with the response to treatment in glioblastomas (GBMs) remain largely unknown. We performed a retrospective study to assess the genomic characteristics associated with the response of GBMs to either first-line chemotherapy or radiation therapy. The gene expression (n = 56) and genomic profiles (n = 67) of responders and non-responders to first-line chemotherapy or radiation therapy alone were compared on Affymetrix Plus 2 gene expression arrays and BAC CGH arrays. RESULTS: According to Verhaak et al.s classification system, mesenchymal GBMs were more likely to respond to radiotherapy than to first-line chemotherapy, whereas classical GBMs were more likely to respond to first-line chemotherapy than to radiotherapy. In patients treated with radiation therapy alone, the response was associated with differential expression of microenvironment-associated genes; the expression of hypoxia-related genes was associated with short-term progression-free
Fingerprint Dive into the research topics of Irinotecan and raltitrexed: An active combination in advanced colorectal cancer. Together they form a unique fingerprint. ...
Table of Contents. Table of Contents 2. List of Tables 7. List of Figures 8. Introduction 9. Global Markets Direct Report Coverage 9. Chemotherapy Induced Neutropenia Overview 10. Therapeutics Development 11. Pipeline Products for Chemotherapy Induced Neutropenia-Overview 11. Pipeline Products for Chemotherapy Induced Neutropenia-Comparative Analysis 12. Chemotherapy Induced Neutropenia-Therapeutics under Development by Companies 13. Chemotherapy Induced Neutropenia-Therapeutics under Investigation by Universities/Institutes 16. Chemotherapy Induced Neutropenia-Pipeline Products Glance 17. Late Stage Products 17. Clinical Stage Products 18. Early Stage Products 19. Unknown Stage Products 20. Chemotherapy Induced Neutropenia-Products under Development by Companies 21. Chemotherapy Induced Neutropenia-Products under Investigation by Universities/Institutes 24. Chemotherapy Induced Neutropenia-Companies Involved in Therapeutics Development 25. Bio-Ker s.r.l 25. Biogenomics Limited 26. Bolder ...
Chemotherapy is the use of anticancer drugs to treat cancer cells. Chemotherapy has been used for many years and is one of the most common treatments for cancer. In most cases, chemotherapy works by interfering with the cancer cells ability to grow or reproduce. Different groups of drugs work in different ways to fight cancer cells. Chemotherapy may be used alone for some types of cancer or in combination with other treatments, such as radiation or surgery. Often, a combination of chemotherapy drugs is used to fight a specific cancer. Certain chemotherapy drugs may be given in a specific order depending on the type of cancer its being used to treat.. While chemotherapy can be quite effective in treating certain cancers, chemotherapy drugs reach all parts of the body, not just the cancer cells. Because of this, there may be many side effects during treatment. Being able to anticipate these side effects can help you and your child prepare and, in some cases, prevent these symptoms from ...
This trial is investigating the efficacy and tolerability of oxaliplatin [Eloxatin] in combination with capecitabine [Xeloda] in untreated patients with locally
Inclusion Criteria:. Histologically confirmed solid tumor malignancy for which platinum-based chemotherapy on a 21-day cycle or 14 day cycle is being recommended. Stage I of the trial: newly diagnosed disease for which neoadjuvant or adjuvant chemotherapy is planned in the curative setting, or metastatic disease. Stage II of the trial: evaluable disease by Response Evaluation Criteria In Solid Tumors (RECIST) criteria must be present for all subjects in the randomized component of the trial- if surgery or radiation is planned, the target lesions may not be so treated until after the assessment of the effect of chemotherapy. Stage I: subjects may have already received no more than 2 cycle of their platinum-based chemotherapy but should not have received other prior chemotherapy regimens with the exception of patients with metastatic disease who received neoadjuvant or adjuvant chemotherapy and that chemotherapy was completed , 6 months prior to enrollment. Stage II: subjects must have received no ...
Chemotherapy combinations commonly used in the treatment of metastatic colorectal cancer include: fluorouracil (5FU) and leucovorin (FU/LV) leucovorin c...
This phase Ib study will evaluate the antimalarial and transmission blocking activity of a single dose of DSM265 or OZ439 in healthy subjects with induced blood
Chemotherapy, not surprisingly, is easy to demonize. There are few treatments that cause such odious side effects, and when taken to its fullest extreme, such as complete ablation of a cancer patients bone marrow in preparation for a bone marrow transplant, chemotherapy can be brutal. Its also true that for advanced solid malignancies, it only tends to produce palliation or a prolongation in survival, not a cure, and people with cancer want a cure. Palliation just isnt that appealing, for obvious reasons. When people think of chemotherapy, they think of hair falling out, nausea and vomiting, fatigue, and death. Since chemotherapy is often given for more advanced malignancies, its sometimes hard to tell how many of these symptoms (other than the hair loss) are due to the cancer and how much they are due to side effects of the chemotherapy, and many people incorrectly blame chemotherapy for the deaths of their loved ones with cancer. Also, because, like radiation therapy, chemotherapy is often ...
Patients median age was 60 years (28-72). All were classified as ECOG 0-1. Each patient received oxaliplatin as a first line treatment. Also prior use of bevacizumab was reported in 12 patients (60%) and anti-EGFR in 5 patients (25%). 70% of them had mutated RAS status and 30% wild-type RAS status.. The median number of cycles given was 10 (2-42). Aflibercept dose reduction was required in 6 patients (30%), and therapy discontinuation due to toxicity in 2 (10%), 1 as a consequence of hypertension and 1 as diarrhea. In all patients, some kind of grade treatment-related adverse events occurred. Most frequently 3-4 grade toxicity observed were: asthenia (20%), neutropenia (20%), hypertension (20%), diarrhea (15%), stomatitis (15%), palmar-plantar erythrodysesthesia (10%) and proteinuria (5%).. In patients evaluable for response, the response rate was 40% and the disease control rate of 73%. In a follow-up median time of 9 months, the progression-free survival median time was 6,5 months (2-23), and ...
Data on 2281 participants from eight RCTs were available from reports of single-agent doxorubicin versus doxorubicin-based combination chemotherapy. Meta-analysis using the fixed effect model detected a higher tumour response rate with combination chemotherapy compared with single-agent chemotherapy (odds ratio [OR= 1.29; 95% confidence interval [CI], 1.03 to 1.60; p = 0.03), but the OR from a pooled analysis using the random effects model and the same data did not achieve statistical significance (OR= 1.26; 95% CI, 0.96 to 1.67; p = 0.10). No significant difference between the two regimens was detected in the pooled one-year mortality rate (OR = 0.87; 95% CI, 0.73 to 1.05; p=0.14) or two-year mortality rate (OR = 0.84; 95% CI, 0.67 to 1.06; p=0.13) (N=2097). Although reporting of adverse effects was limited and inconsistent among trials (making pooling of data for this outcome impossible), adverse effects such as nausea/vomiting and hematologic toxic effects were consistently reported as being ...
Chemotherapy is a systemic method of cancer treatment, in contrast with local therapies such as surgery and radiation therapy. The drugs used in chemotherapy are able to reach most parts of the body. Therefore, chemotherapy is likely to be recommended for cancer that has already spread to other areas of the body, for tumors that occur at more than one site, or for tumors that cannot be removed surgically. It is also used when a patient has recurrent disease after initial treatment with surgery or radiation therapy.. Chemotherapy is less mutilating than surgery and helps conserve organ or limb function since anti-cancer drugs are used to act on cancer cells without direct removal of a body part.. For some cancers, chemotherapy alone can destroy all the cancer cells and cure the cancer (primary treatment). As an adjuvant treatment, chemotherapy is given prior to, or after other methods, to increase the effectiveness of cancer treatment. Most often, adjuvant chemotherapy is given after other ...
Nausea and vomiting are common side effects of chemotherapy drugs that are used to treat cancer. Some chemotherapy drugs are worse offenders than others In most cases, patients will be given anti-vomiting (antiemetics) and anti-nausea medication prior to the administration of chemotherapy. Some of the commonly used antiemetics are listed in the chart below. As you can see, these drugs may also have some side effects of their own.
This paper considers the consensus problem of nonlinear multi-agent systems under switching directed topologies. Specifically, the dynamics of each agent incorporates an intrinsic nonlinear term and the interaction topology may not contain a spanning tree at any time. By designing a state-controlled switching law, we show that the multi-agent system with the neighbor-based protocol can achieve consensus if the switching topologies jointly contain a spanning tree. Moreover, an easily manageable algebraic criterion is deduced to unravel the underlying mechanisms in reaching consensus. Finally, a numerical example is exploited to illustrate the effectiveness of the developed theoretical results.
Roche noted that a Phase III IMpower150 study met its co-primary endpoint of progression-free survival (PFS) and demonstrated that the combination of TECENTRIQ (atezolizumab) and Avastin (bevacizumab) plus chemotherapy (paclitaxel and carboplatin) provided a statistically significant and clinically meaningful reduction in the risk of disease worsening or death (PFS) compared to Avastin plus chemotherapy in the first-line treatment of people with advanced non-squamous non-small cell lung cancer (NSCLC). Initial observations for the co-primary endpoint of overall survival (OS) are encouraging. These data are not fully mature and the next OS analysis is expected in the first half of 2018. Safety for the TECENTRIQ and Avastin plus chemotherapy combination appeared consistent with the known safety profile of the individual medicines, and no new safety signals were identified with the combination ...
Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.. January 17, 2017/Novato, California: Standard chemotherapy is a blunt force instrument against cancer - and its a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells, both malignant and healthy, throughout the body. Researchers at the Buck Institute and elsewhere now show that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse. The research is published in Cancer Discovery.. While chemotherapy does save lives, it often comes with a very high price, said Judith Campisi, PhD, Buck faculty and senior scientist on the study. Our work in mice studied the effects of chemotherapy on cancer relapse and other serious side effects. It provides a ...
Lung, breast, and colorectal cancers are the 3 most frequent causes of cancer-related death in the United States. In the past 15 years, survival has increased dramatically for patients with these tumor types, partly because improved chemotherapy caused major changes in standard care. In addition, maintaining chemotherapy dose intensity has an established a positive effect on patient outcomes. However, delivering chemotherapy at full dose and on schedule is limited primarily by myelosuppression. To determine how expert opinion about preferred chemotherapy for lung, breast, and colorectal cancers has changed over the past decade, the National Comprehensive Cancer Network (NCCN) treatment guidelines from 1996, 2000 or 2001, and 2005 for each tumor type were compared. The myelosuppressive potentials of NCCN-recommended agents were assessed using data from their prescribing information. Many agents and combinations of agents recommended in the NCCN guidelines for treating lung, breast, and colorectal ...
Median follow-up was 16.1 months (5.1-39.0) in the FOLFOX-FOFIRI regimen and 19.9 months (4.0-46.6) in the XELOX-XELIRI regimen. Ten patients were treated with bevacizumab in either a first or second setting in the FOLFOX-FOFIRI regimen, whereas 20 patients were treated with bevacizumab in the XELOX-XELIRI regimen. In the first-line chemotherapy, DCR was 85.0% in the FOLFOX regimen and 58.5% in the XELOX regimen, whereas, in the second-line chemotherapy, DCR was 50.0% in the FOLFIRI regimen and 41.4% in the XELIRI regimen. In the first-line chemotherapy, the median PFS was 6.5 months in the FOLFOX regimen and 6.0 months in the XELOX regimen (p = 0.127). In the second-line chemotherapy, the median PFS was 4.6 months in the FOLFIRI regimen and 4.0 months in the XELIRI regimen (p = 0.370). The median OS was 24.5 months in the FOLFOX-FOFIRI regimen and 23.2 months in the XELOX-XELIRI regimen (p = 0.994). The median TI was 14.0 months in the FOLFOX-FOFIRI regimen and 12.0 months in the XELOX-XELIRI ...
For women with early-stage breast cancer who are receiving chemotherapy, shortening the time between treatment cycles or administering the agents sequentially may reduce disease recurrence and mortality compared with standard chemotherapy regimens.
AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused on discovering, developing and commercializing cancer therapeutics, today announced preliminary results from an ongoing Phase 1b clinical trial evaluating the companys lead product candidate, tivozanib, a highly potent and selective inhibitor of VEGF receptors 1, 2, and 3, in combination with paclitaxel (Taxol®), a standard chemotherapy regimen, in patients with metastatic breast cancer.
PURPOSE To evaluate the role of early intensification with high-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) as front-line chemotherapy for patients with high-risk, histologically aggressive non-Hodgkins lymphoma (NHL). PATIENTS AND METHODS We planned a multicenter, randomized trial to compare a conventional chemotherapy regimen of methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B; arm A) with an abbreviated regimen of MACOP-B (8 weeks) followed by HDT and ASCT (arm B) for intermediate-high-risk/high-risk patients (according to the age-adjusted International Prognostic Index). From September 1994 to April 1998, 150 patients with aggressive lymphoma were enrolled onto the trial. Seventy-five patients were randomly assigned to arm A and 75 patients were randomly assigned to arm B. In both arms, involved-field radiation therapy (36 Gy) was delivered to the site of bulky disease. RESULTS The rate of complete
Advanced or metastatic breast cancer is cancer that has spread beyond the breast and underarm lymph nodes to other parts of the body. Although metastatic breast cancer is often responsive to conventional chemotherapy it does not provide a cure. The dose of chemotherapy that can be given to an individual is limited because it is unsafe in high doses and can seriously damage the bone marrow, creating high risk of serious infection. One treatment that was considered promising at the start of the 1990s was use of autograft, which involves transplantation of a womans own bone marrow or peripheral stem cells to regenerate her bone marrow. Autografting allowed the administration of chemotherapy doses many times higher than could otherwise be used. This systematic review aimed to compare the evidence from randomised controlled trials comparing high dose chemotherapy with conventional chemotherapy.. This review identified six randomised trials including 437 women receiving high dose chemotherapy with ...
received REG and FTD/TPI, respectively. The REG group received more prior systemic chemotherapies and significantly more frequent additional chemotherapies than the FTD/TPI group did. The median follow-up was 6.2 months, whereas the median overall survival was 9.9 and 11.4 months in the REG and FTD/TPI groups, respectively (hazard ratio = 0.954, p = 0.837). The median progression-free survival was 2.0 and 3.3 months in the REG and FTD/TPI groups, respectively (hazard ratio = 0.52, p = 0.00047), indicating significant differences, whereas the objective response and disease control rates did not differ. The median overall survival of patients with additional subsequent chemotherapies after disease progression was longer than that of patients without additional chemotherapy. The most frequent grade ≥3 adverse events were hypertension and neutropenia in the REG and FTD/TPI groups, respectively. Our study suggested that sequential use of both drugs may prolong survival. ...
Key Findings. The median number of neoadjuvant cycles of FOLFIRINOX was six.. Among the 520 patients, 343 (66.0%) received adjuvant chemotherapy, including FOLFIRINOX in 19.8%, gemcitabine-based chemotherapy in 58.6%, capecitabine in 4.1%, a combination or other agents in 13.1%, and unknown chemotherapy in 4.4%. A total of 177 patients received no adjuvant chemotherapy.. Median overall survival was 29 months in the adjuvant therapy group vs 29 months in the no adjuvant therapy group (hazard ratio [HR] = 0.99; 95% confidence interval [CI] = 0.77-1.28, P = .93). On multivariate analysis, the hazard ratio was 0.85 (95% CI = 0.35-2.10, P = .73).. On multivariate analysis, only the interaction term of nodal status with adjuvant chemotherapy was significant. Among the 50% vs 38% of patients with pathology-proven, node-positive disease, median overall survival was 26 months with adjuvant chemotherapy vs 13 months with no adjuvant chemotherapy (HR = 0.41, 95% CI = 0.22-0.75, P = .004). Among patients ...
Background: This multicenter phase II study investigated the efficacy and feasibility of preoperative induction chemotherapy followed by chemoradiation and surgery in patients with esophageal carcinoma. Patients and methods: Patients with locally advanced resectable squamous cell carcinoma or adenocarcinoma of the esophagus received induction chemotherapy with cisplatin 75 mg/m2 and docetaxel (Taxotere) 75 mg/m2 on days 1 and 22, followed by radiotherapy of 45 Gy (25 × 1.8 Gy) and concurrent chemotherapy comprising cisplatin 25 mg/m2 and docetaxel 20 mg/m2 weekly for 5 weeks, followed by surgery. Results: Sixty-six patients were enrolled at eleven centers and 57 underwent surgery. R0 resection was achieved in 52 patients. Fifteen patients showed complete, 16 patients nearly complete and 26 patients poor pathological remission. Median overall survival was 36.5 months and median event-free survival was 22.8 months. Squamous cell carcinoma and good pathologically documented response were ...
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of neoplasm-related death in the United States. Several studies analyzed the efficacy of bevacizumab combined with different chemotherapy regimens consisting on drugs such as 5-FU, capecitabine, irinotecan and oxaliplatin. This systematic review aims to evaluate the effectiveness and safety of chemotherapy plus bevacizumab versus chemotherapy alone in patients with previously untreated advanced or metastatic colorectal cancer (mCRC). Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. The primary endpoints were overall survival and progression-free survival. Data extracted from the studies were combined by using hazard ratio (HR) or risk ratio (RR) with their corresponding 95 % confidence intervals (95 % CI). The final analysis included 9 trials comprising 3,914 patients. Patients who received the combined treatment (chemotherapy + bevacizumab) had higher response rates (RR =
Clinical trial for childhood ALL | leukemia , Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute Lymphocytic Leukemia
PURPOSE: A randomized three-arm phase II study was undertaken to evaluate the optimum administration schedule of pemetrexed and gemcitabine in chemotherapy-naïve patients with non-small-cell lung cancer. PATIENTS AND METHODS: Patients were randomly assigned to three schedules of pemetrexed 500 mg/m2 plus gemcitabine 1,250 mg/m2, separated by a 90-minute interval, on a 21-day cycle as follows: schedule A, pemetrexed followed by gemcitabine on day 1 and gemcitabine on day 8; schedule B, gemcitabine followed by pemetrexed on day 1 and gemcitabine on day 8; and schedule C, gemcitabine on day 1 and pemetrexed followed by gemcitabine on day 8. RESULTS: One hundred fifty-two eligible patients (schedule A, n = 59; schedule B, n = 31, and schedule C, n = 62) received a median of five (schedule A), two (schedule B), and four (schedule C) treatment cycles. Overall, 66% of patients experienced grade 3 or 4 neutropenia. Common grade 3 and 4 nonhematologic toxicities were dyspnea (11%), fatigue (16%), and
On March 27, the U.S. Food and Drug Administration (FDA) approved durvalumab (Imfinzi) in combination with etoposide and either carboplatin or cisplatin as first-line treatment of patients with extensive-stage small cell lung cancer (SCLC).. CASPIAN Trial. Efficacy of this combination in patients with previously untreated extensive-stage SCLC was investigated in CASPIAN, a randomized, multicenter, active-controlled, open-label phase III trial. The evaluation was based on the comparison of patients randomly assigned to durvalumab plus chemotherapy vs chemotherapy alone. The major efficacy outcome measure was overall survival; additional efficacy outcome measures were investigator-assessed progression-free survival and objective response rate per Response Evaluation Criteria in Solid Tumors, version 1.1.. Median overall survival was 13.0 months (95% confidence interval [CI] = 11.5-14.8) in the durvalumab-plus-chemotherapy arm vs 10.3 months (95% CI = 9.3-11.2) in the chemotherapy-alone arm (hazard ...
The impact of adding bevacizumab to perioperative chemotherapy in patients with colorectal cancer (CRC) undergoing liver resection is yet to be defined. A retrospective review of our patient records showed that the addition of bevacizumab did not increase morbidity or mortality related to liver resection. Pathologic complete response (CR) is associated with prolonged survival. Background: Patients with colorectal cancer (CRC) and liver metastases benefit from perioperative chemotherapy and liver resection. The potential benefit of adding bevacizumab is yet to be defined. The impact of bevacizumab on liver resection complications has been explored in a small number of retrospective studies. Methods: The records of patients with CRC and liver metastases who underwent liver resection and had received perioperative chemotherapy were reviewed. Complications were reported separately for 2 groups (chemotherapy alone vs chemotherapy and bevacizumab). Survival outcomes (progression-free survival [PFS] ...
TY - JOUR. T1 - Long-term complete remission with nab-paclitaxel, bevacizumab, and gemcitabine combination therapy in a patient with triple-negative metastatic breast cancer. AU - Montero, Alberto. AU - Glück, Stefan. PY - 2012/9/1. Y1 - 2012/9/1. N2 - This is a case study of a 52-year-old female patient diagnosed in June 2007 with primary metastatic invasive ductal carcinoma of the left breast and synchronous metastases in the bone, lymph nodes, and lung. Biopsy results of the tumor tissue were negative for the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2). In November 2007, she participated in a phase II study of metastatic HER2-negative breast cancer. Treatment consisted of systemic chemotherapy with gemcitabine 1,500 mg/m 2, nab-paclitaxel 150 mg/m2, and bevacizumab 10 mg/kg once every other week. The patient experienced pain relief in her sternum after 5 weeks of chemotherapy, and her analgesic therapy was discontinued. After 7 months, the ...
The purpose of this investigation was to evaluate the efficacy of cisplatin chemotherapy in BRCA1 mutation carriers with metastatic breast cancer. In a phase II, open-label study, 20 patients with metastatic breast cancer who carried a mutation in BRCA1 were treated with cisplatin 75 mg/m2 intravenously every 3 weeks as part of a 21-day cycle for 6 cycles. Restaging studies to assess response were performed after cycles 2 and 6, and every three months thereafter. Between July 2007 and January 2009, 20 patients were enrolled. Baseline characteristics were as follows: 65% had prior adjuvant chemotherapy, 55% had prior chemotherapy for metastatic breast cancer; mean age was 48 years (ranges 32 to 70); 30% estrogen receptor (ER) or progesterone receptor (PR)+, 70% ER/PR/Human Epidermal Growth Factor Receptor 2 (HER2)- and 0% HER2+. Overall response rate was 80%; nine patients experienced a complete clinical response (45%) and seven experienced a partial response (35%). Overall survival was 80% at one year,
TY - JOUR. T1 - Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer. AU - Rocconi, Rodney P.. AU - Stevens, Erin E.. AU - Bottsford-Miller, Justin N.. AU - Ghamande, Sharad A.. AU - Elder, Jeffrey. AU - DeMars, Leslie L.. AU - Munkarah, Adnan. AU - Aaron, Phylicia. AU - Stanbery, Laura. AU - Wallraven, Gladice. AU - Bognar, Ernest. AU - Manley, Meghan. AU - Horvath, Staci. AU - Manning, Luisa. AU - Walter, Adam. AU - Galanis, Evanthia. AU - Herzog, Thomas. AU - Monk, Bradley J.. AU - Coleman, Robert L.. AU - Nemunaitis, John. N1 - Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.. PY - 2021. Y1 - 2021. N2 - Vigil® is a personalized vaccine that enhances tumor neoantigen expression. We investigated for the first time safety and efficacy of Vigil in combination with atezolizumab in relapsed ovarian cancer (OC) patients. This is a randomized, Phase 1 study of Vigil, an autologous tumor tissue ...
TY - JOUR. T1 - Seeing the forest through the trees. T2 - A systematic review of the safety and efficacy of combination chemotherapies used in the treatment of metastatic colorectal cancer. AU - Bekaii-Saab, Tanios. AU - Wu, Christina. PY - 2014/7. Y1 - 2014/7. N2 - Combinations of fluoropyrimidines with oxaliplatin or irinotecan plus a biologic agent are standard treatments for metastatic colorectal cancer (mCRC). Recent approvals of first-line cetuximab, second-line ziv-aflibercept, and regorafenib as salvage therapy have increased the complexity of the treatment armamentarium. To define optimal regimens, we systematically reviewed combination chemotherapy trials (N= 83). Descriptive analyses focusing on fluoropyrimidine formulation, oxaliplatin vs irinotecan combinations, and compatibility with biologics indicated the following: infusional 5-fluorouracil (5-FU) yielded better efficacy and safety than bolus 5-FU. Capecitabine had similar outcomes and better safety than 5-FU with oxaliplatin ...
Study is Second Positive Phase III Trial of Rituxan Plus Chemotherapy in Most Common Adult Leukemia. SOUTH SAN FRANCISCO, Calif. & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Genentech, Inc. (NYSE:DNA) and Biogen Idec (Nasdaq:BIIB) today announced that a global Phase III study of Rituxan® (rituximab) in combination with fludarabine and cyclophosphamide chemotherapy met its primary endpoint of improving progression-free survival (PFS), as assessed by investigators, in patients with previously treated CD20-positive chronic lymphocytic leukemia (CLL) compared to chemotherapy alone. There were no new or unexpected safety signals reported in the study. An independent review of the primary endpoint is being conducted for U.S. regulatory purposes.. Data from the study, REACH, will be submitted for presentation at a future medical meeting. Earlier this year, another European Phase III study, CLL-8, showed a similar treatment combination improved PFS in patients with CLL who had not previously received ...
Single arm, open label, Phase IB study of indibulin capsules in subjects with advanced solid tumors; eligible subjects will have a baseline PET scan sho
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Similarly claims that chemotherapy have produced increased percentage 5-year survival for other cancers, such as cancer of the large bowel1, could be attributed to poor methodology because none of these cancers exhibited a divergence between incidence and mortality rate curves over time5.. Ulrich Abel reviewed the evidence for the efficacy of chemotherapy for invasive epithelial cancer6, the types of cancer for which chemotherapy is most commonly used. He concluded that there was some evidence from randomised trials that chemotherapy increased survival only for small-cell lung cancer. Yet even here the gain in survival was measured in weeks or months.. Adjuvant chemotherapy for breast cancer It is widely claimed that adjuvant chemotherapy extends survival with late-stage breast cancer. For example, in a letter in the Sydney Morning Herald of 22 November 1996 Professor Allan Langlands claimed that the results of a meta-analysis of more than 100 trials of adjuvant systemic therapy in many ...
TY - JOUR. T1 - Adverse effects of bevacizumab and their management in solid tumors. AU - Arriaga, Yull. AU - Becerra, Carlos R.. PY - 2006/7. Y1 - 2006/7. N2 - Bevacizumab is the first successful example of targeting the vasculature for the treatment of solid tumors. Although generally well tolerated in combination with different chemotherapy regimens, bevacizumab has side effects that are unique to this class of agents. In this review, we discuss the side effects associated with bevacizumab and potential treatments to ameliorate these toxicities.. AB - Bevacizumab is the first successful example of targeting the vasculature for the treatment of solid tumors. Although generally well tolerated in combination with different chemotherapy regimens, bevacizumab has side effects that are unique to this class of agents. In this review, we discuss the side effects associated with bevacizumab and potential treatments to ameliorate these toxicities.. KW - Bleeding. KW - Gastrointestinal ...
This volume highlights new trends and challenges in research on agents and the new digital and knowledge economy, and includes 23 papers classified into the following categories: business process management, agent-based modeling and simulation, and anthropic-oriented computing. All papers were originally presented at the 11th International KES Conference on Agents and Multi-Agent Systems - Technologies and Applications (KES-AMSTA 2017) held June 21-23, 2017 in Vilamoura, Algarve, Portugal. Todays economy is driven by technologies and knowledge. Digital technologies can free, shift and multiply choices, and often intrude on the territory of other industries by providing new ways of conducting business operations and creating value for customers and companies. The topics covered in this volume include software agents, multi-agent systems, agent modeling, mobile and cloud computing, big data analysis, business intelligence, artificial intelligence, social systems, computer embedded systems and