BACKGROUND Conventional meta-analyses have shown inconsistent results for efficacy of pharmacological treatments for acute mania. We did a multiple-treatments meta-analysis, which accounted for both direct and indirect comparisons, to assess the effects of all antimanic drugs. METHODS We systematically reviewed 68 randomised controlled trials (16,073 participants) from Jan 1, 1980, to Nov 25, 2010, which compared any of the following pharmacological drugs at therapeutic dose range for the treatment of acute mania in adults: aripiprazole, asenapine, carbamazepine, valproate, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, quetiapine, risperidone, topiramate, and ziprasidone. The main outcomes were the mean change on mania rating scales and the number of patients who dropped out of the allocated treatment at 3 weeks. Analysis was done by intention to treat. FINDINGS Haloperidol (standardised mean difference [SMD] -0·56 [95% CI -0·69 to -0·43]), risperidone (-0·50 [-0·63 to -0·38),
Shudderer (Shu) is an X-linked dominant mutation in Drosophila melanogaster identified more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and defects in reactive climbing behavior, and that these phenotypes were significantly suppressed when mutants were fed food containing lithium, a mood stabilizer used in the treatment of bipolar disorder (Williamson, 1982). This unique observation suggested that the Shu mutation affects genes involved in lithium-responsive neurobiological processes. In the present study, we identified Shu as a novel mutant allele of the voltage-gated sodium (Nav) channel gene paralytic (para). Given that hypomorphic para alleles and RNA interference-mediated para knockdown reduced the severity of Shu phenotypes, Shu was classified as a para hypermorphic allele. We also demonstrated that lithium could improve the behavioral abnormalities displayed by other Nav mutants, including a fly model of the human generalized epilepsy with febrile seizures plus.
Bipolar mood disorder (manic depression) is a major psychiatric disorder whose molecular origins are unknown. Mood stabilisers offer patients both acute and prophylactic treatment, and experimentally, they provide a means to probe the underlying biology of the disorder. Lithium and other mood stabilisers deplete intracellular inositol and it has been proposed that bipolar mood disorder arises from aberrant inositol (1,4,5)-trisphosphate [IP3, also known as Ins(1,4,5)P3] signalling. However, there is no definitive evidence to support this or any other proposed target; a problem exacerbated by a lack of good cellular models. Phosphatidylinositol (3,4,5)-trisphosphate [PIP3, also known as PtdIns(3,4,5)P3] is a prominent intracellular signal molecule within the central nervous system (CNS) that regulates neuronal survival, connectivity and synaptic function. By using the genetically tractable organism Dictyostelium, we show that lithium suppresses PIP3-mediated signalling. These effects extend to ...
TY - JOUR. T1 - A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents. AU - Geller, Barbara. AU - Luby, Joan L.. AU - Joshi, Paramjit. AU - Wagner, Karen Dineen. AU - Emslie, Graham. AU - Walkup, John T.. AU - Axelson, David A.. AU - Bolhofner, Kristine. AU - Robb, Adelaide. AU - Wolf, Dwight V.. AU - Riddle, Mark A.. AU - Birmaher, Boris. AU - Nusrat, Nasima. AU - Ryan, Neal D.. AU - Vitiello, Benedetto. AU - Tillman, Rebecca. AU - Lavori, Philip. PY - 2012/5. Y1 - 2012/5. N2 - Context: There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents. Objective: To investigate which medication to administer first to antimanic medication-naive subjects. Design, Setting, and Participants: The Treatment of Early Age Mania (TEAM) study recruited 6-to 15-year-old children and adolescents with ...
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Anticonvulsant, antimanic agent. Epilepsy: Adults and children , 12 years - initially, 100-200 mg once or twice a day; increased in divided doses until best response obtained. Optimal daily dosage: 800-1200 mg. Rarely, …. ...
Anticonvulsant, antimanic agent. Epilepsy: Adults and children , 12 years - initially, 100-200 mg once or twice a day; increased in divided doses until best response obtained. Optimal daily dosage: 800-1200 mg. Rarely, …. ...
How to Treat Bipolar Disorder in Children. Bipolar disorder in children is marked by mood swings, irritability, trouble concentrating, and feelings of hopelessness or worthlessness. Left untreated, bipolar disorder can have poor effects on...
The study is a double-blind, placebo-controlled 8-week trial of pioglitazone, either as monotherapy or adjunctive to a mood stabilizer, for the acute relief of bipolar depression. The enrollment goal is 80 subjects (40 patients each in the pioglitazone treatment group and the placebo treatment group).. Screening Phase: Patients who have been prescribed a mood stabilizer for , 4 weeks and are on a therapeutic dose will proceed directly to the Screening Visit. For situations in which the patient prefers to be taking a mood stabilizer or where the treating psychiatrist feels it is clinically necessary, a mood stabilizer (lithium, divalproex, carbamazepine, lamotrigine, olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone or lurasidone) will be initiated (see Mood Stabilizer Initiation section below). For this set of patients who do begin a mood stabilizer, the Screening Phase may last up to 8 weeks. Otherwise, subjects who do not come in on a mood stabilizer will proceed directly to ...
The concept of mood stability is attractive to both patients and clinicians alike, and hence the term mood stabilizer has widespread currency. However, its worldwide acceptance and use in clinical practice is at odds with the absence of official recognition by regulatory authorities. The ideal mood stabilizer is said to have efficacy in the treatment of acute manic and depressive episodes, and also be effective in the prevention of recurrences. However, in reality, few drugs with perhaps the exception of lithium, come close to this gold standard; yet many agents aspire to the title, and some have arguably achieved it prematurely. It is, therefore, important to reconsider the definition of a mood stabilizer and critically review which agents, if any, satisfy the necessary eligibility requirements by reference to reasonable criteria and comparator data. The term mood stabilizer is an important label. It needs to be applied judiciously because it confers clinical credibility and qualifies long-term use
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The goal of this table is to offer a guide for physician and pharmacist in combining mood stabilizers. The table should be clear, easy to use and contains the most important information. Therefore, the table only contains the most commonly used mood stabilizers ...
In a recently published study from Turkey, close to 50% of manic patients who took the drug Tamoxifen had fewer manic episodes during the three weeks of treatment, compared to just 5% of placebo-treated patients. About 25 percent of Tamoxifen-treated patients and none of the placebo-treated patients achieved remissions.
Read a comprehensive review of the effects of specific mood-stabilizing agents on fetuses and nursing infants, and the appropriate management guidelines to minimize these risks.
Read a comprehensive review of the effects of specific mood-stabilizing agents on fetuses and nursing infants, and the appropriate management guidelines to minimize these risks.
Lamictal is a remarkable anticonvulsant mood stabilizer. What makes it so remarkable is that it is very frequently effective in the depressed phase of
Important Information for Women Who Could Become Pregnant About the Use of DEPAKOTE® (divalproex sodium) Tablets. Please read this leaflet carefully before you take DEPAKOTE® (divalproex sodium) tablets. This leaflet provides a summary of important information about taking DEPAKOTE to women who could become pregnant. If you have any questions or concerns,or want more information about DEPAKOTE, contact your doctor or pharmacist.. Information For Women Who Could Become Pregnant. DEPAKOTE can be obtained only by prescription from your doctor. The decision to use DEPAKOTE is one that you and your doctor should make together, taking into account your individual needs and medical condition.. Before using DEPAKOTE, women who can become pregnant should consider the fact that DEPAKOTE has been associated with birth defects, in particular, with spina bifida and other defects related to failure of the spinal canal to close normally. Approximately 1 to 2% of children born to women with epilepsy taking ...
Important Information for Women Who Could Become Pregnant About the Use of DEPAKOTE® (divalproex sodium) Tablets. Please read this leaflet carefully before you take DEPAKOTE® (divalproex sodium) tablets. This leaflet provides a summary of important information about taking DEPAKOTE to women who could become pregnant. If you have any questions or concerns,or want more information about DEPAKOTE, contact your doctor or pharmacist.. Information For Women Who Could Become Pregnant. DEPAKOTE can be obtained only by prescription from your doctor. The decision to use DEPAKOTE is one that you and your doctor should make together, taking into account your individual needs and medical condition.. Before using DEPAKOTE, women who can become pregnant should consider the fact that DEPAKOTE has been associated with birth defects, in particular, with spina bifida and other defects related to failure of the spinal canal to close normally. Approximately 1 to 2% of children born to women with epilepsy taking ...
Lurasidone (trade name Latuda) is an atypical antipsychotic developed by Dainippon Sumitomo Pharma and marketed by Sunovion in the U.S. It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013. It can be used alone or in combination with mood stabilizers such as lithium or valproate (e.g., Depakote ...
Lurasidone (trade name Latuda) is an atypical antipsychotic developed by Dainippon Sumitomo Pharma and marketed by Sunovion in the U.S. It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013. It can be used alone or in combination with mood stabilizers such as lithium or valproate (e.g., Depakote ...
Medications for bipolar disorder include lithium, anticonvulsants, antipsychotics, antidepressants, and ketamine. Learn about their side effects and benefits.
Medications for bipolar disorder include lithium, anticonvulsants, antipsychotics, antidepressants, and ketamine. Learn about their side effects and benefits.
Study Unit 4: Mood Disorders, Mood Stabilizers, and ADHD flashcards from Justin Holmes's University of Colorado Medical School class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Learn Antipsychotics, Mood Stabilizers, ADD Drugs facts using a simple interactive process (flashcard, matching, or multiple choice). Finally a format that helps you memorize and understand. Browse or search in thousands of pages or create your own page using a simple wizard. No signup required!
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has anyone been on a mood stabilizer drug ? if so did it worsen tinnitus?? my doctor might try this instead of antidepressant to see if it helps my...
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Nexium is a strong and powerful painkiller for the treatment of chronic pain. Many more of the people taking zyprexa would have benefited from other drugs, such as the mood stabilizer lithium.
Teva-Olanzapine: Olanzapine belongs to a group of medications known as antipsychotic/antimanic agents. Olanzapine is used to treat schizophrenia and related mental disorders, as well as bipolar disorder.
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Mood-stabilizing drugs slipped into the vocabulary of psychiatrists during the last 15 years without a proper discussion of their definition. Consequently, these medications have been used in ways that have no empirical justification.
When patients with classic mania and depression during mania are considered together, evidence suggests that acute treatment responses to lithium and divalproex
Valproate is under-used and greatly under-dosed in acute mania. Mono-therapy with high-dose valproate is the first-choice preference by a wide margin.. It has less side effects and a wider margin of safety than any of the other relevant drugs. It is much less expensive than almost any other option.. If adequately dosed, is almost certainly much more effective, despite the paucity of evidence for this from RCTs. That simply speaks to the fact that RCTs are frequently unhelpful, and as Parker has said (26), they produce clinically meaningless results.. It is therefore important for clinicians to develop and trust their clinical judgement, and stop deferring too readily and too often to the sometimes mis-informed conclusions promulgated by the committees that produce these guidelines - for a discussion of the extensive problems with guidelines see my recent commentary.. It reminds me of one of the factors that speeded my departure from the National Health Service in the UK many years ago. The ...
Buy Setinin Online! Setinin is an antipsychotic medicine. Setinin is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.
U.S. manufacturers, including major drugmakers, have legally released at least 271 million pounds of pharmaceuticals into waterways that often provide drinking water - contamination the federal government has consistently overlooked, according to an Associated Press investigation.. Hundreds of active pharmaceutical ingredients are used in a variety of manufacturing, including drugmaking: For example, lithium is used to make ceramics and treat bipolar disorder; nitroglycerin is a heart drug and also used in explosives; copper shows up in everything from pipes to contraceptives.. Federal and industry officials say they dont know the extent to which pharmaceuticals are released by U.S. manufacturers because no one tracks them - as drugs. But a close analysis of 20 years of federal records found that, in fact, the government unintentionally keeps data on a few, allowing a glimpse of the pharmaceuticals coming from factories.. As part of its ongoing PharmaWater investigation about trace ...
Background:Divalproex sodium has been reported to be better tolerated than valproic acid. To our knowledge, no study has examined whether significant differences in the tolerability and efficacy exist between these preparations in psychiatric patients. The objective of the present study was to compare the tolerability and efficacy of divalproex sodium with those of valproic acid in psychiatric inpatients.. Method:Information gathered retrospectively from the medical records of 150 patients treated with divalproex sodium was compared with that of 150 patients treated with valproic acid. These medical records were photocopied, and any mention of divalproex sodium or valproic acid treatment was concealed. A series of demographic and clinical characteristics were compared. Results: Patients treated with divalproex sodium compared with patients treated with valproic acid were less likely to have gastrointestinal side effects (14.7% vs. 28.7%, p = .003), specifically anorexia (6.0% vs. 14.7%, p = ...
redOrbit Staff & Wire Reports - Your Universe Online. Researchers from the University of South Florida (USF) have reportedly discovered that an alternative salt form of lithium might be a safer, less toxic way to treat bipolar disorder and other neuropsychiatric conditions.. Publishing a paper in a recent edition of RSC Advances, the journal of the Royal Society of Chemistry, the study authors discuss how oral lithium salicylate was able to produce steady lithium levels for up to 48 hours in rats - without the toxic side effects typically linked with the rapid absorption of current FDA-approved lithium carbonate.. While lithium carbonate has been tremendously effective in treating the mania associated with bipolar disorder, as well as reducing the likelihood of suicide during the depressive phases of the condition, it can also cause such side effects as diarrhea, vomiting, weight gain, hand tremors and even decreased thyroid function.. As a result of those adverse effects, patients often stop ...
Canadian pharmaceutical companies are reporting shortages of divalproex sodium (Epival), also known as valproic acid.. As of Thursday December 17, a total of fifteen divalproex sodium shortages were posted on drugshortages.ca by Abbott Laboratories Limited*, Apotex Inc., Pro Doc Limitée, Sanis Health Inc. and Teva Canada Limited. None of the pharmaceutical companies have provided an explanation for the shortages.. This situation is a serious concern. The estimated resupply dates currently range from December 24, 2015 to April 30, 2016. These dates are estimates and could change. Drug shortages, or back-orders, at the level of the pharmaceutical companies do not always result in shortages at community and hospital pharmacies. Although the longer a shortage lasts the greater the likelihood that it could have an impact on patients.. If you or a family member have been prescribed divalproex sodium (Epival), contact your pharmacist and ask about the availability of your medication.. If your ...
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TY - JOUR. T1 - Association of chronic divalproex sodium use and brain atrophy in Alzheimers disease. AU - Han, Changsu. AU - Shim, Dong Suk. AU - Lee, Soo Jung. AU - Patkar, Ashwin A.. AU - Masand, Prakash S.. AU - Pae, Chi Un. PY - 2012/2. Y1 - 2012/2. N2 - Divalproex sodium has been widely use for the treatment of bipolar disorder, behavioral control in schizophrenia, seizure and agitation in Alzheimers disease. With the advent of other mood stabilizers and anticonvulsants, the use of divaplroex sodium has been slightly decreased; however, it has been a major mediation for the treatment of such medical conditions. Beyond symptomatic effects on such neuropsychiatric conditions, it has also been proposed to hold some neurotoxicity effects, including reversible brain atrophy (which may be a serious complication associated with substantial cognitive decline), although it has shown neuroprotective effects. Common adverse events include sedation, tiredness and gastrointestinal symptoms. According ...
Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), including divalproex sodium delayed-release capsules, during pregnancy. Encourage women who are taking divalproex sodium delayed-release capsules during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling toll-free 1-888-233-2334 or visiting the website, http://www.aedpregnancyregistry.org/. This must be done by the patient herself. Risk Summary For use in prophylaxis of migraine headaches, valproate is contraindicated in women who are pregnant and in women of childbearing potential who are not using effective contraception [see Contraindications (4)].]. For use in epilepsy or bipolar disorder, valproate should not be used to treat women who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable [see Boxed Warning ...
Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), including divalproex sodium extended-release tablets, during pregnancy. Encourage women who are taking divalproex sodium extended-release tablets during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling toll-free 1-888-233-2334 or visiting the website, http://www.aedpregnancyregistry.org/. This must be done by the patient herself. Risk Summary For use in prophylaxis of migraine headaches, valproate is contraindicated in women who are pregnant and in women of childbearing potential who are not using effective contraception [see Contraindications (4)]. For use in epilepsy or bipolar disorder, valproate should not be used to treat women who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable [see Boxed Warning ...
TY - JOUR. T1 - Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar i disorder. AU - Torres, I. J.. AU - Defreitas, C. M.. AU - Defreitas, V. G.. AU - Bond, D. J.. AU - Kunz, M.. AU - Honer, W. G.. AU - Lam, R. W.. AU - Yatham, L. N.. PY - 2011/5/1. Y1 - 2011/5/1. N2 - Background Although cognitive deficits in bipolar disorder have been associated with diminished functional outcome, this relationship has been studied primarily through cross-sectional designs, and has not been studied in patients early in the course of illness. The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder. Method A total of 53 recently diagnosed patients with DSM-IV bipolar disorder type I were assessed within 3 months of their first manic episode using a neuropsychological battery measuring ...
The more you know about bipolar disorder, the better you will be able to cope with this lifelong illness. There are many steps that you can take-or help a loved one take-to recognize and better manage manic episodes. Learn the warning signs of a manic episode, and get early treatment to avoid disruption in your life...
We present expert consensus guideline recommendations for the treatment of bipolar depression. These were arrived at through the statistical aggregation of the survey responses of 61 leading clinical researchers to eight questions about the key decision points in the management of bipolar depression. The experts first-line recommendation for treating psychotic depression in bipolar disorder is to provide a combination of mood stabilizer, antidepressant, and neuroleptic medication. For severe, but nonpsychotic bipolar depression, the experts recommend the combination of a mood stabilizer and an antidepressant. For milder bipolar depression, a mood stabilizer and an antidepressant together or a mood stabilizer alone would be first line. The experts antidepressant dose and dosing schedule recommendations are equivalent for unipolar and bipolar depression, but the experts recommend a faster discontinuation of antidepressants during the maintenance phase in bipolar patients-probably to reduce the ...
Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential sociodemographic and clinical risk factors associated with a longer hospitalization. Such information could be useful to identify those patients at high risk for long LOS and to allocate them to special treatments, with the aim of optimizing their hospital management. This was a cross-sectional study recruiting adult patients with a diagnosis of bipolar disorder (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) criteria) who had been hospitalized due to an acute manic episode with a Young Mania Rating Scale total score greater than 20. Bivariate correlational and multiple linear regression analyses were performed to identify independent predictors of LOS. A total of 235 patients from 44 centers were included in the study. The only factors that were
High blood sugar levels may put patients with bipolar disorder at risk of not responding to lithium and other mood stabilizer treatments.
Description of disease Bipolar I disorder. Treatment Bipolar I disorder. Symptoms and causes Bipolar I disorder Prophylaxis Bipolar I disorder
While medications such as valproate (Depakote and others) and lithium are generally considered first-line agents in late life bipolar disorder, side effects are common, and many individuals with bipolar disorder continue to have symptoms in spite of medication treatment. A continuing unmet need is the availability of medications that are generally well- tolerated and effective in later life bipolar disorders.. Antipsychotic medications such as Abilify are known to be effective for related conditions such as schizophrenia and are also used by some physicians in clinical settings in combination with mood stabilizing medications (Lithium, Depakote and others) to treat symptoms of bipolar disorder. Currently Abilify is approved by the FDA to treat schizophrenia and to treat bipolar disorder. ...
What is this medicine? DIVALPROEX SODIUM (dye VAL pro ex SO dee um) is used to treat certain types of seizures in patients with epilepsy.
Mylan Institutional Inc.: Divalproex sodium extended-release tablets are indicated for: Acute treatment of manic or mixed episodes associated with bipolar...
Treating bipolar disorder effectively involves a combination of psychotherapy, appropriate medications, support, and self-care. Several types of therapy may be used to treat bipolar disorder, and medications include antidepressants, mood stabilizers, and antipsychotics, which help to relieve symptoms of depression, minimize mania, and stabilize mood between episodes. With commitment to a treatment plan, support from family, and good self-care, bipolar disorder can be managed.
For more than 60 years, the mood stabilizer lithium has been used alone or in combination for the treatment of bipolar disorder, schizophrenia, depression and other mental illnesses. Despite this long history, the molecular mechanisms trough which lithium regulates behavior are still poorly understood. Among several targets, lithium has been shown to directly inhibit glycogen synthase kinase 3 alpha and beta (GSK3α and GSK3β). However in vivo, lithium also inhibits GSK3 by regulating the activity of other mechanisms like the formation of a signaling complex comprised of beta-arrestin 2 and Akt. Here, we provide an overview of in vivo evidence supporting a role for inhibition of GSK3 in some behavioral effects of lithium. We also explore how regulation of GSK3 by lithium within a signaling network involving several molecular targets and cell surface receptors (e.g. G protein coupled receptors and receptor tyrosine kinases) may provide cues to its relative pharmacological selectivity and its effects on
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OBJECTIVE: Little is known regarding the relationship between treatment adherence and residual cognitive dysfunction in euthymic bipolar disorder patients. This study aimed to investigate whether poor treatment adherence is associated with cognitive impairment in euthymic bipolar patients and whether other factors may be associated with both adherence and cognitive functioning. METHOD: Euthymic DSM-IV bipolar I or II disorder patients (N = 103: 61 with high levels of treatment adherence and 42 with poor treatment adherence) were assessed using a neuropsychological battery targeting attention, psychomotor speed, verbal memory, and executive functions and compared with 35 healthy controls of similar age, sex distribution, and education. Data were collected from September 2005 to June 2007. RESULTS: Bipolar patients with poor treatment adherence had more hospitalizations than those with high adherence. After controlling for age, gender, estimated IQ score, and Young Mania Rating Scale and 17-item Hamilton
The efficacy offor treating mania was discovered in 1949, making it the first medication specifically developed to treat bipolar disorder. Lithium remains a mainstay of treatment for bipolar disorder, especially for acute mania and maintenance treatm
Your question has to do with maintenance treatment for someone with bipolar disorder who presumably has been free of episodes of mania and depression for three years. To prevent or decrease the frequency of further episodes, maintenance (or prophylactic) treatment is employed.. Lithium is the main agent, but increasingly other drugs are used instead of or in addition to it. Divalproex or valproic acid (Depakote and Depakene) and carbamazapine (Tegretal) are the main so-called mood stabilizers used.. Antidepressants are used in the treatment of depressive episodes but generally are not used for long-term maintenance. Indeed, the use of antidepressants, especially alone, can cause manic episodes and instability, especially in rapid-cycling patients.. Individuals who are stable for a long time and who have mild histories may be considered for cessation of maintenance treatment. This should be done with caution under supervision. Id have to know a lot more about your particular history to know ...
Bipolar I disorder is referred to as manic depression. Manic depression presents differently for each individual, but the diagnosis requires a history of at least one manic episode. A manic episode involves a period of time in which emotions are elevated in a positive direction, often for no particular reason. Brief elation at a piece of good news is not manic, but a few weeks of that feeling could indicate mania.. Individuals with bipolar I often spiral into depression following episodes of mania. Depression can wreak havoc on your life and even result in suicidal thoughts. Between cycles, individuals who suffer from bipolar I disorder usually lead fairly normal lives ...