CD26 and CD31 surface antigen expression on human colostral T cells.: The expression levels of CD26 and CD31 surface antigens, two adhesion/activation molecules
Lubaroff, D M., "Antigenic markers on rat lymphocytes. I. Characterization of a.r.t., An alloantigenic marker on rat thymus and thymus-derived cells." (1977). Subject Strain Bibliography 1977. 2102 ...
Tumor cells were treated with rabbit antibody to tumor-associated cell surface antigens and tested with erythrocytes coated with antibody specific for the sensitizing rabbit immunoglobulin. The sensitized tumor cells formed rosettes with the indicator cells. By this method, we confirmed that line 1 and line 10 hepatoma cells (from two tumors independently induced by diethylnitrosamine in strain 2 guinea pigs) bear antigens not present on normal liver cells. We also confirmed that line 1 and line 10 cells bear antigenically different tumor-associated cell surface antigens. This method appears simpler than other serological methods for detecting tumor-associated cell surface antigens on tumor cells. Also, this method may be a general one for detecting and enumerating cells bearing surface antigens.. ...
The pathogen. · Has antigens which identify it as foreign. Infected cells. · May damage attacking pathogens with organelles such as lysosomes and display them on their surface membrane (antigen presentation). Macrophages. · Act like phagocytes, engulfing and digesting any pathogens. · Separate out antigens from digested pathogens and display them in antigen presentation. · Release monokines which attract neutrophils and stimulate B and T cell division and differentiation. T cells. · Matching T cells detect the antigen using receptors on their cell membranes- this…. ...
The TandAb technology enables the development of innovative antibody therapeutics for improved treatment of various diseases. This platform has been primarily applied to oncology and comprises of CD3 RECRUIT- and CD16A RECRUIT-TandAbs for activation of T and NK effector cells, respectively, and lysis of target cells expressing specific surface antigens. The CD3 RECRUIT-TandAb AFM11 is a human bispecific tetravalent antibody with two binding sites for the α-chain of CD3 and two binding sites for CD19. CD19 is expressed at early stages of B cell development and persists until the final differentiation into plasma cells. Thus, CD19 represents an attractive target for the treatment of various B cell malignancies including leukemias and lymphomas that lack CD20 expression or are refractory to anti-CD20 antibody therapies. In vitro cytotoxicity assays employing tumor cell lines demonstrate high potency of AFM11 in mediating target cell lysis: EC50 values are in the low to sub-picomolar range ...
Fenyo, E M. and Grundner, G, "Expression of virus-controlled cell surface antigen(s) in hybrids between mouse l cells (a9 subline) and various mouse and human cells derived from tumours and normal tissues. Abstr." (1971). Subject Strain Bibliography 1971. 647 ...
Monoclonal antibodies to human T lymphocyte surface structures have essentially contributed to a better understanding of cellular mechanisms and interactions involved in the generation of human T...
[140 Pages Report] The cell surface markers market is valued at an estimated USD 520 million in 2018 and is projected to reach USD 769 million by 2023, at a
TY - JOUR. T1 - Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. AU - Cui, Tianpen. AU - Miksa, Michael. AU - Wu, Rongqian. AU - Komura, Hidefumi. AU - Zhou, Mian. AU - Dong, Weifeng. AU - Wang, Zhimin. AU - Higuchi, Shinya. AU - Chaung, Wayne. AU - Blau, Steven A.. AU - Marini, Corrado P.. AU - Ravikumar, Thanjavur S.. AU - Wang, Ping. PY - 2010/2/1. Y1 - 2010/2/1. N2 - Rationale: Milk fat globule epidermal growth factor 8 (MFG-E8) is a potent opsonin for the clearance of apoptotic cells and is produced by mononuclear cells of immune competent organs including the spleen and lungs. It attenuates chronic and acute inflammation such as autoimmune glomerulonephritis and bacterial sepsis by enhancing apoptotic cell clearance. Ischemia-reperfusion (I/R) injury of the gut results in severe inflammation, apoptosis, and remote organ damage, including acute lung injury (ALI). Objectives: To determine whether MFG-E8 attenuates ...
Cardiac hypertrophy occurs in response to numerous stimuli like neurohumoral stress, pressure overload, infection, and injury, and leads to heart failure. Mfge8 (milk fat globule-EGF factor 8) is a secreted protein involved in various human diseases, but its regulation and function during cardiac hypertrophy remain unexplored. Here, we found that circulating MFGE8 levels declined significantly in failing hearts from patients with dilated cardiomyopathy. Correlation analyses revealed that circulating MFGE8 levels were negatively correlated with the severity of cardiac dysfunction and remodeling in affected patients. Deleting Mfge8 in mice maintained normal heart function at basal level but substantially exacerbated the hypertrophic enlargement of cardiomyocytes, reprogramming of pathological genes, contractile dysfunction, and myocardial fibrosis after aortic banding surgery. In contrast, cardiac-specific Mfge8 overexpression in transgenic mice significantly blunted aortic banding-induced cardiac ...
VlsE, the variable surface antigen of Borrelia burgdorferi, consists of two invariable domains at the amino and carboxyl termini and one central variable domain. The latter contains six invariable regions, IR(1) to IR(6), and six variable regions. In the present study, the antigenicity of all of the invariable regions in B. burgdorferi-infected monkeys, humans, and mice was assessed by peptide-based enzyme-linked immunosorbent assays. Only one invariable region, IR(6), was antigenic in all animals of the three host species. IR(2) and IR(4) were also antigenic in mice ...
TY - JOUR. T1 - Identification of Naturally Processed Helper T-Cell Epitopes from Prostate-Specific Membrane Antigen Using Peptide-Based in Vitro Stimulation. AU - Kobayashi, Hiroya. AU - Omiya, Ryusuke. AU - Sodey, Benjamin. AU - Yanai, Mitsuru. AU - Oikawa, Kensuke. AU - Sato, Keisuke. AU - Kimura, Shoji. AU - Senju, Satoru. AU - Nishimura, Yasuharu. AU - Tateno, Masatoshi. AU - Celis, Esteban. PY - 2003/11/1. Y1 - 2003/11/1. N2 - Purpose: There is growing evidence that CD4+ helper T lymphocytes (HTLs) play an essential role in the induction and long-term maintenance of antitumor CTL responses. Thus, approaches to develop effective T-cell-based immunotherapy should focus in the stimulation of both CTLs and HTLs reactive against tumor-associated antigens. The present studies were performed with the purpose of identifying HTL epitopes for prostate-specific membrane antigen (PSMA) for the optimization of vaccines for prostate cancer. Experimental Design: Synthetic peptides from regions of the ...
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Solving the Convergence Problem in the Synthesis of Triantennary N-Glycan Relevant to Prostate-Specific Membrane Antigen (PSMA) Journal Article ...
Picture of Chemical structure of prostate-specific membrane antigen (PSMA,.. stock photo, images and stock photography.. Image 16083639.
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is overexpressed in prostate cancer. Radiolabeled small molecules that bind with high affinity to its active extracellular center have emerged as a potential new diagnostic standard of reference for prostate cancer, resulting in images with extraordinary tumor-to-background contrast.
Journal: EJNMMI - European Journal of Nuclear Medicine and Molecular Imaging ArticleTitle: Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-a preliminary analysis
TY - JOUR. T1 - Integrin-associated protein. T2 - A 50-kD plasma membrane antigen physically and functionally associated with integrins. AU - Brown, Eric. AU - Hooper, Lora. AU - Ho, Thang. AU - Gresham, Hattie. PY - 1990/12/1. Y1 - 1990/12/1. N2 - Phagocytosis by monocytes or neutrophils can be enhanced by interaction with several proteins or synthetic peptides containing the Arg-Gly-Asp sequence. Recently we showed that an mAb, B6H12, specifically inhibited this enhancement of neutrophi1 phagocytosis by inhibiting Arg-Gly-Asp binding to the leukocyte response integrin (Gresham, H.D., J.L. Goodwin, P.M. Allen, D.C. Anderson, and E.J. Brown. 1989. J. Cell Biol. 108:1935-1943). Now, we have purified the antigen recognized by B6H12 to homogeneity. Surprisingly, it is a 50-kD molecu1e that is expressed on the plasma membranes of all hematopoietic cells, including erythrocytes, which express no known integrins. On platelets and placenta, but not on erythrocytes, this protein is associated with an ...
Complete information for MFGE8 gene (Protein Coding), Milk Fat Globule-EGF Factor 8 Protein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The CD56 antigen is a 140 kDa isoform of the Neural Cell Adhesion Molecule (N-CAM). Post-translational modifications to the polypeptide include N- and O- glycosylations, acylation, sulphation and phosphorylation. The different N-CAM isoforms have molecular weights ranging from 135 to 220 kDa. The CD56 antigen is moderately expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with NK activity. It is also expressed by subsets of T lymphocytes. CD56 antibodies do not react with granulocytes, monocytes or B cells.
TY - JOUR. T1 - T cell recognition of QA-1b antigens on cells lacking a functional Tap-2 transporter. AU - Aldrich, C. J.. AU - Waltrip, R.. AU - Hermel, E.. AU - Attaya, M.. AU - Lindahl, K. F.. AU - Monaco, J. J.. AU - Forman, J.. PY - 1992/12/1. Y1 - 1992/12/1. N2 - MHC class Ia H chains and β2-microglobulin assemble with appropriate peptides to form stable cell surface molecules that serve as targets for Ag- specific CTL. The structural similarities of class Ia and the less polymorphic Q/T/M (class Ib) molecules suggest that class Ib molecules also play a role in antigen presentation, although the origin of the peptides they present remains mostly unclear. The cell line RMA-S has a defect in class I Ag presentation, presumably due to a mutation in a peptide transporter gene. This defect can be overcome by transfection of RMA-S cells with the Tap-2 gene (formerly Ham-2) that encodes an ATP-binding transporter protein. We now show that a substantial portion of alloreactive CTL specific for ...
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Looking for differentiation antigen? Find out information about differentiation antigen. A cell surface antigen that is expressed only during a specific period of embryological differentiation Explanation of differentiation antigen
There is an urgent need for an effective treatment for metastatic prostate cancer (PC). Prostate tumors invariably overexpress prostate surface membrane antigen (PSMA). We designed a nonviral vector, PEI-PEG-DUPA (PPD), comprising polyethylenimine-polyethyleneglycol (PEI-PEG) tethered to the PSMA ligand, 2-[3-(1, 3-dicarboxy propyl)ureido] pentanedioic acid (DUPA), to treat PC. The purpose of PEI is to bind polyinosinic/polycytosinic acid (polyIC) and allow endosomal release, while DUPA targets PC cells. PolyIC activates multiple pathways that lead to tumor cell death and to the activation of bystander effects that harness the immune system against the tumor, attacking nontargeted neighboring tumor cells and reducing the probability of acquired resistance and disease recurrence ...
Y Nakamura, M Noma, M Kidokoro, N Kobayashi, M Takei, S Kurashima, T Mukaiyama, S Kato; Expression of CD33 antigen on normal human activated T lymphocytes [letter]. Blood 1994; 83 (5): 1442-1443. doi: https://doi.org/10.1182/blood.V83.5.1442.bloodjournal8351442. Download citation file:. ...
Immunofluorescence labeling of cell surface antigens in Dictyostelium. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
cal microscopy and flow cytometry studies were employed to examine the involvement of these processes in the uptake of F-Ab40 by neuronal cells. Localization of
BioMagnetic Solutions has engineered next generation ferrofluids (nano-magnetic liquids) with enhanced magnetics for selective recovery and/or enrichment of cells expressing specific surface antigens or for capturing macromolecules. The augmented magnetic character of our materials increases their magnetic pull which lowers limits of detection and saves time (in concert with our more powerful quadrupole and hexapole magnets) enabling researchers to work more efficiently.. ...
Shop Surface antigen ELISA Kit, Recombinant Protein and Surface antigen Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Hepatitis A Surface Antigen Antibodies available through Novus Biologicals. Browse our Hepatitis A Surface Antigen Antibody catalog backed by our Guarantee+.
During the last several years, the prostate-specific membrane antigen (PSMA) and corresponding radiolabeled inhibitors have become one of the most …
AppliedStemCell eCommerce Platform anti-SSEA-1 (m), monoclonal antibody [ASA-0135] - The SSEA family is a group of cell-surface antigenic markers expressed on ES/iPS cells. SSEA-1 is highly expressed in mouse ES/iPS cells but not in human ES/iPS cells. Ap
Role of γ/δ T cell surface molecules and soluble mediators in DC maturation. (A) CD40 ligand cell surface expression by JR.2. γ/δ T cells. CD40 ligand expre
Australský antigen je označení pro antigen viru hepatitidy B, který se nachází na povrchu virových částic. Označuje se též jako „surface antigen" (HBsAg). Diagnostika přítomnosti antigenu v krvi je důležitá pro diagnostiku hepatitidy B ...
Mouse anti Human CD163 antibody, clone EDHu-1 recognizes the human CD163 cell surface antigen, a 130-140 kDa glycoprotein expressed by tissue macropha
PSMA兔多克隆抗体(ab41034)可与人样本反应并经WB, ICC/IF实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
When a specific frequency of light is shone on the tissue, the reporter can be made to fluoresce. The presence of fluorescent color would then indicate that the antibody, and thus the antigen, is present in the tissue, meaning that the cell would be positive for the cluster of differentiation being identified.[7] ...
Prostate-specific Membrane Antigen Antibody-Drug Conjugate (PSMA ADC) 1301EXT is an open-label, nonrandomized, phase 1 extension study of PSMA ADC administered IV in subjects with progressive CMPC that has progressed after prior taxane therapy. Subjects who have participated in PSMA ADC 1301 and who, in the opinion of the PI, are likely to benefit from continued treatment with PSMA ADC will be enrolled in PSMA ADC 1301EXT ...
Cell lines derived from human small cell carcinoma of the lung express high levels of a surface polypeptide termed the cluster-w4 antigen, which was previously identified as a potential target for toxin-based immunotherapy of lung cancer. We have cloned a complementary DNA encoding the cluster-w4 antigen from COS-1 fibroblasts transfected with a SW2 small cell carcinoma library, by panning with a mixture of the cluster-w4-specific monoclonal antibodies SWA11, SWA21, and SWA22. The sequence of the cluster-w4 complementary DNA encodes an unusually short (80-amino acid) protein identical to that recently reported for the leukocyte activation molecule CD24 except for a single valine-alanine substitution due to a single-base polymorphism within the region of the gene coding for the extracellular domain. Biochemical analyses of the cloned cluster-w4 antigen confirmed both the presence of the phosphatidylinositol tail and the extensive glycosylation reported for the CD24 molecule. Furthermore, the cloned
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is an important diagnostic and therapeutic target in prostate cancer. PSMA/GCPII is also expressed in many healthy tissues, but its function has only been established in the brain and small intestine.
Chronic pain often accompanies immune-related diseases with an elevated level of IgG immune complex (IgG-IC) in the serum and/or the affected tissues though the underlying mechanisms are largely unknown. shown that neuronal FcRI triggers a nonselective cation channel, which may contribute to the IgG-IC-induced excitation of DRG neurons[19,30]. Moreover, TRPC3 acts as a novel and crucial downstream transduction channel mediating… More →. ...
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While many cell types produce type I IFN in vitro when exposed to double-stranded (ds)RNA and some RNA viruses, a specialized leukocyte is responsible for the IFN-α production induced by a wider spectrum of agents, including viruses, bacteria, protozoa, certain cell lines, and also unmethylated CpG-DNA (6-8). This major IFN-α-producing cell (IPC) was early on designated natural IPC (NIPC) and subsequent work (for a review see reference 6) revealed that NIPCs were infrequent (∼0.1% of PBMCs) but very productive on a per cell basis (∼10 pg IFN-α per cell). The expression of the IFN-α/β genes induced in NIPCs was markedly dependent on costimulation ("priming") of the cells by cytokines, in particular IL-3, GM-CSF, and type I IFNs. These cells lacked lineage specific surface antigens, but expressed MHC class II (for a review, see reference 6). The NIPCs were shown to express, e.g., CD4, CD36, CD40, CD44, CD45RA, and CD83, but lacked CD80, CD86, and CD11c, suggesting they were immature DCs ...
The human 5T4 oncofoetal antigen is expressed by all types of trophoblast in pregnancy but is not detected on most adult tissues, although low levels are found on some epithelia. However, this antigen is strongly expressed by many cancers and tumour-associated labelling correlates with metastatic spread and poor clinical outcome for patients with gastric and colon cancer. Over-expression of the gene influences cell adhesion, shape and motility, which may be related to changes in the cellular localisation of the 5T4 oncofoetal antigen as malignancy develops. To establish whether the 5T4 oncofoetal antigen can serve as a tumour-specific marker for oral cancer and precancer, we have evaluated the pattern of expression on biopsies of normal, inflamed and dysplastic oral mucosa using immunohistochemistry. Oral mucosa, taken from different sites in the mouth, expressed the 5T4 oncofoetal antigen with varying intensity and pattern. The majority of the immunoreactivity was detected in the basal and ...
Virtually all human granular lymphocytes expressed the HNK-1 differentiation antigen when examined in lymphoid compartments from adults, neonates, and fetuses. The HNK-1+ cells were distinguishable into three subsets having distinct antigenic phenotypes: HNK+T3-M1-, HNK+T3+M1-, and HNK+T3-M1+. Thus, greater than 70% of the HNK-1+ cells from 13-17 wk fetuses (less than 0.2% of nucleated cells) lacked T cell antigens (e.g., T3, T8, T4, and T6) and the M1 myeloid antigen. Morphologically, the HNK+T3-M1- cells consisted of three different types: small granular lymphocytes (less than 10% of HNK-1+ cells), agranular small lymphocytes with a narrow rim of cytoplasm (70-80%), and agranular giant cells (greater than 15 micrometers) with considerable neutrophilic cytoplasm (15%). The purified fetal HNK-1+ cells exhibited a low level of cytotoxicity against K562 target cells. On the other hand, almost all of HNK-1+ cells in neonatal tissues as well as adult bone marrow, lymph node, and thymus, exhibited ...
Cell surface markers are proteins expressed on the surface of cells that often conveniently serve as markers of specific cell types. For example, T cell and B cell surface markers identify their lineage and stage in the differentiation process. These lymphocytes differentiate into multiple cell subtypes, necessary for specific biological processes. During this process, lymphocytes express different surface receptors, which can be used to identify cellular subtypes, such as progenitor cells or terminally differentiated T helper cells. Inappropriate cellular ratios of differentiated white blood cells, such as the relative amounts of Th1 and Th2 cells, occur in pathophysiological conditions such as autoimmunity. The presence of cell surface markers can also determine if a cell type expresses the specific receptor important for a biological response. Testing for surface marker expression is also essential to determine if an experimental drug or ligand will be recognized by the cell type of interest. ...
By means of the indirect membrane immunofluorescence test, the distribution and antibody-induced redistribution (patching and capping) of a mammary tumor virus-induced (MLr) and a normal (Thy 1.2) cell-surface antigen were compared on mouse thymocytes and leukemia cells (GRSL2). At 0 degrees C Thy 1.2 fluorescence was ringlike and more intense on GRSL2 cells than on thymocytes, whereas MLr fluorescence on GRLS2 cells at this temperature was patchlike and brighter than Thy 1.2 fluorescence. At 20 or 37 degrees C, capping of Thy 1.2 on both cell types was readily achieved but MLr capping occurred only in a few GRSL2 cells and was less pronounced. However, after addition of the secondary antibodies, MLr capping was markedly increased by gradual cooling of cells to about 17 degrees C. Conversely, after addition of antibodies at 0 degrees C, gradual warming of cells under the fluorescence microscope resulted in extensive capping both of MLr and Thy 1.2 at approximately 13-14 degrees C. Rapid cooling ...
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly important tissue sample preparation technique is the initial preparation of cohesive multicellular particulates of the tissue sample. For assays concerning cancer treatment, a two-stage evaluation is contemplated in which both acute cytotoxic and longer term inhibitory effect of a given anti-cancer agent are investigated. The tissue sample technique of the present invention is also useful in assaying expression and/or secretion of various markers, factors or antigens present on or produced by the cultured cells for diagnostic purposes and for using such expression to monitor the applicability of certain candidate therapeutic or chemotherapeutic agents and the