The distribution of Ole e I (the major olive pollen allergen) and its transcripts was investigated in the anther from premeiotic stages until the dehiscent pollen stage. Crude protein extracts were analyzed by immunoblotting and probed with a monoclonal antibody to Ole e I. The protein, with three variants, was found to accumulate from the early microspore stage onwards. In addition to the previously reported localization of the protein, Ole e I has been immunolocalized for the first time within the pollen wall and in the tapetum. Reverse transcription-polymerase chain reaction analysis using specific oligonucleotides and RNA extracted from whole anthers revealed that the Ole e I gene is expressed from the late tetrad stage onwards. No expression was found in control tissues such as petals, roots or leaves. Light microscopy in situ hybridization on developing flower buds and dehiscent pollen confirmed the transcripts to be present in both the microspores and the sporophytic tissue (tapetum). ...
Hollenbach, B., Schreiber, L., Hartung, W., & Dietz, K. - J. (1997). Cadmium leads to stimulated expression of the lipid transfer protein genes in barley: Implications for the involvement of lipid transfer proteins in wax assembly. Planta, 203(1), 9-19. doi:10.1007/ ...
casSAR Dugability of A0AT31 | NLTP5 | Non-specific lipid-transfer protein 5 - Also known as NLTP5_LENCU, NLTP5. Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
protease inhibitor/seed storage/lipid transfer protein (LTP) family protein; FUNCTIONS IN: lipid binding; INVOLVED IN: lipid transport; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Bifunctional inhibitor/plant lipid transfer protein/seed storage (InterPro:IPR016140), Plant lipid transfer protein/seed storage/trypsin-alpha amylase inhibitor (InterPro:IPR003612), Plant lipid transfer protein and hydrophobic protein, helical (InterPro:IPR013770); BEST Arabidopsis thaliana protein match is: protease inhibitor/seed storage/lipid transfer protein (LTP) family protein (TAIR:AT4G12510.1); Has 534 Blast hits to 530 proteins in 51 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 534; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink ...
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
Lipid-transfer proteins (LTP) are type of proteins, 9-kDa proteins present in high quantity as much as 4 percent of the total soluble protein in higher plants. Lipid-transfer proteins (LTP) are responsible for transfer (in vitro), of phospholipids between membranes as well as binds to acyl chains. Some important roles played by LTP are embryogenesis, participation in cutin formation, symbiosis, and the adaptation of plants to various environmental conditions and defense reactions against phytopathogens, though the validity of some these roles is needs to be determined. Recent studies show several important functions in the cell. Biosynthesis of many membrane lipids occurs at the (ER) endoplasmic reticulum, then they are dispensed by vesicular transport and lipid transfer proteins. Lysosomal lipid transfer proteins are types of proteins are multifunctional in nature. Though the mechanism and functions of most LTPs are yet to be determined, lipid transfer proteins in plants are involved in surface ...
1FK0: Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
1FK4: Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
El Archivo Digital UPM alberga en formato digital la documentacion academica y cientifica (tesis, pfc, articulos, etc..) generada en la Universidad Politecnica de Madrid.Los documentos del Archivo Digital UPM son recuperables desde buscadores: Google, Google Academics, Yahoo, Scirus, etc y desde recolectores OAI: E-ciencia, DRRD, Recolecta (REBIUN-FECYT), Driver, Oaister, etc.
In addition to Equ c 1, another horse lipocalin allergen, Equ c 2, is expressed. (23) Lipocalin allergens are usually present in hair dandruff.. Lipocalins are members of the calycin superfamily. Despite the diversity at the primary sequence level and a sequence identity often less than 20%, all lipocalins share a conserved folding pattern, a similar three-dimensional structure and one to three conserved regions: an 8-stranded ß-barrel flanked by an a-helix at the C-terminal end of the polypeptide chain. (3, 26) The central cavity of the lipocalin ß-barrel serves for the binding and transport of small hydrophobic molecules such as retinol (retinol-binding protein), odorant molecules (bovine odorant-binding protein), and pheromones (as in mouse and rat: mouse major urinary protein, mMUP1, and rat urinary a2-globulin). (2). Although the overall amino acid identity between lipocalins is usually below 20%, in some cases the sequential identity over animal species can be well above 20%. For ...
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Metastasis, the spreading of cancer cells from a primary tumor to seed secondary tumors in distant sites, is the main cause of mortality in breast cancer patients (Oppenheimer, 2006). Recent studies suggest that EMT plays a central role in motility and dissemination of cancer cells (Thiery et al., 2009). This dynamic and reversible process is necessary for efficient metastatic colonization (Brabletz, 2012) and is regulated by several signaling cascades that activate specific transcription factors (Huber et al., 2005).. In this study, we show that the PtdIns-transfer protein Nir2 potentiates EMT in mammary cells (Fig. 3) and is required for lung metastasis of breast cancer cells (Fig. 6). Remarkably, the expression level of Nir2 is upregulated in response to EMT inducers (Fig. 3A), such as EGF and TGFβ, and is markedly enhanced in human breast cancer tissue (Fig. 7). These results introduce Nir2 as a new positive regulator of EMT and breast cancer metastasis. Indeed, depletion of Nir2 by shRNA ...
Jeal H, Draper A, Harris J, Taylor AN, Cullinan P, Jones M, Determination of the T cell epitopes of the lipocalin allergen, Rat n 1. Clin Exp Allergy. 2004 Dec;34(12):1919-25 ...
Latest Plant Lipids Private Limited import data and Plant Lipids Private Limited export data along with the details of top 25 importers and exporters of similar products.
Analysis of the purified recombinant Gly m 4l protein.(A) The recombinant Gly m 4l protein induced with 0.5 mM IPTG at 37°C for 1-5 h in E.coli BL21 (DE3). (
Antimicrobial activity of the recombinant Gly m 4l protein.(A) The antimicrobial activity of the recombinant Gly m 4l protein against the hyphal growth of P. so
Ve srovn n ty zem zosob uj c ch Evropu se jako nejv t pij ci uk zali e i. V c ne p t polo ek si d t m ka d p t . V tomto ohledu pijeme v ce ne D nov .
As of today, applications for the specialization at the E&I Institute will be accepted again. The application deadline is September 6, 2020 at 23:59.
Dekubitus ili dekubitalni ulkus je oštećenje kože koje nastaje uslijed dugotrajnog povećanog pritiska na određeni dio tijela. Na nastanak dekubitusa djeluju endogeni i egzogeni čimbenici i unatoč raznim antidekubitalnim pomagalima dekubitus ostaje veliki zdravstvenosocijalni problem. Glavni uzrok dekubitusa je dugotrajni lokalni pritisak na predilekcijska mjesta gdje se on najčešće i pojavljuje. Dekubitus može nastati bez obzira na položaj u kojem se bolesnik nalazi. Bitno je procjenjivati predilekcijska mjesta za nastanak dekubitusa i učinjene postupke evidentirati u sestrinsku dokumentaciju služeći se skalama za dekubitus. Educirano osoblje i kvalitetna njega, kao glavni korak u prevenciji dekubitusa, uključuje i mobilizaciju pacijenata te aktivno i pasivno vježbanje u krevetu. Dekubitus je progresivni proces koji, ako se ne prevenira pritisak, može dovesti do teških oštećenja kože i/ili potkožnih struktura. Razlikujemo četiri stupnja dekubitusa. Prvi stupanj ...
Zajistíme profesionální syntézu oligonukleotidů pro laboratoře i soukromé osoby. Výrazně tak ušetříte při výzkumu jednovláknových molekul DNA. Kontaktuje BIOGEN Praha pro syntézu oligonukleotidů.
Bet v 1l is a naturally occurring hypoallergenic isoform of the major birch pollen allergen Bet v 1. The Bet v 1 protein belongs… Expand ...
One example of a diagnostic application of recombinant birch allergens is found in a study examining allergen-specific serum IgE antibodies using the recombinant allergens Bet v 1, Bet v 2 and Bet v 4, as examined in birch-sensitive patients from the province of Cuneo, in northwestern Italy. It was reported that of 372 patients, 215 (58%) had serum IgE antibodies to Bet v 1, 166 (45%) to Bet v 2, and 35 (9%) to Bet v 4. Mono-sensitisation to Bet v 1 occurred in 146 (39%) of patients; in 96 (26%) to Bet v 2; and in only 4 (1%) to Bet v 4. Thirty-nine sera (11%) did not contain allergen-specific IgE antibodies to any of these three individual birch pollen allergens. All 372 sera (100%) had IgE antibodies against natural Birch pollen extract; 162 (44%) contained IgE antibodies reacting with Apple extract (75% of Bet v 1 positive sera). The study concluded that the 3 recombinant birch pollen allergens alone could identify 90% of birch pollen-sensitive patients (7 ...
This study intend to verify whether the different levels of severity of the clinical allergic reactions to peach are associated to sensitization towards different allergenic molecules of peach. In particular, we will analyze the reactivity towards the peach allergens Pru p 1, Pru p 3 and Pru p 4 and towards the birch pollen allergens Bet v 1, Bet v 2 and Bet v 4. The patients (with allergic symptoms of any severity provoked by the consumption of peach) will be divided into two groups: the first group showing oral allergy syndrome (OAS), the second group showing systemic symptoms of different severity, up to anaphylaxis.. All the patients will be submitted to: complete clinical investigation; skin prick test with a panel of common food/inhalant commercial extracts; skin tests by the prick + prick method with fresh fruits and vegetables; skin prick test with purified peach LTP (Pru p 3) The sera of the patients will be used for: immunoblotting with peach extract and immunoblotting inhibition ...
In Northern and Central Europe, a considerable percentage of pollen and food allergies in adults is caused by allergenic proteins of the Bet v 1-family. This protein family whose name is derived from the major birch pollen allergen belongs to class 10 of the pathogenesis-related proteins (PR10 proteins). These proteins play a role in the immune system of the plant, but their precise physiological function has not been determined yet. Structural studies of members of the Bet v 1-family will not only provide new information regarding their physiological function, but are also an important prerequisite for the production of hypo-allergenic protein variants for immunotherapy. So far, the structures of three different Bet v 1-allergens have been solved. All of them show the typical Bet v 1-fold: a seven-stranded, antiparallel beta-sheet and two short V-shaped alpha-helices which in combination with a long C-terminal alpha-helix form a hydrophobic cavity in the protein. During this work, the ...
Specific allergy vaccination is an efficient treatment for allergic disease; however, the development of safer vaccines would enable a more general use of the treatment. Determination of molecular structures of allergens and allergen-Ab complexes facilitates epitope mapping and enables a rational approach to the engineering of allergen molecules with reduced IgE binding. In this study, we describe the identification and modification of a human IgE-binding epitope based on the crystal structure of Bet v 1 in complex with the BV16 Fab fragment. The epitope occupies approximately 10% of the molecular surface area of Bet v 1 and is clearly conformational. A synthetic peptide representing a sequential motif in the epitope (11 of 16 residues) did not inhibit the binding of mAb BV16 to Bet v 1, illustrating limitations in the use of peptides for B cell epitope characterization. The single amino acid substitution, Glu(45)-Ser, was introduced in the epitope and completely abolished the binding of mAb ...
BACKGROUND: The major birch pollen allergen, Bet v 1, is a member of theubiquitous PR-10 family of plant pathogenesis-related proteins. In recentyears, a number of diverse plant proteins with low sequence similarity toBet v 1 was identified. In addition, determination of the Bet v 1structure revealed the existence of a large superfamily of structurallyrelated proteins. In this study, we aimed to identify and classify all Betv 1-related structures from the Protein Data Bank and all Bet v 1-relatedsequences from the Uniprot database. RESULTS: Structural comparisons ofrepresentative members of already known protein families structurallyrelated to Bet v 1 with all entries of the Protein Data Bank yielded 47structures with non-identical sequences. They were classified into elevenfamilies, five of which were newly identified and not included in theStructural Classification of Proteins database release 1.71. The taxonomicdistribution of these families extracted from the Pfam protein familydatabase ...
BACKGROUND: The major birch pollen allergen, Bet v 1, is a member of theubiquitous PR-10 family of plant pathogenesis-related proteins. In recentyears, a number of diverse plant proteins with low sequence similarity toBet v 1 was identified. In addition, determination of the Bet v 1structure revealed the existence of a large superfamily of structurallyrelated proteins. In this study, we aimed to identify and classify all Betv 1-related structures from the Protein Data Bank and all Bet v 1-relatedsequences from the Uniprot database. RESULTS: Structural comparisons ofrepresentative members of already known protein families structurallyrelated to Bet v 1 with all entries of the Protein Data Bank yielded 47structures with non-identical sequences. They were classified into elevenfamilies, five of which were newly identified and not included in theStructural Classification of Proteins database release 1.71. The taxonomicdistribution of these families extracted from the Pfam protein familydatabase ...
The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small fraction of the whole CD4(+) T cell repertoire and can be isolated from the peripheral blood of humans according to their cytokine profile. Freshly purified interferon-gamma-, interleukin (IL)-4-, and IL-10-producing allergen-specific CD4(+) T cells display characteristics of T helper cell (Th)1-, Th2, and T regulatory (Tr)1-like cells, respectively. Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals; in contrast, there is a high frequency of allergen-specific IL-4-secreting T cells in allergic individuals. Tr1 cells use multiple suppressive mechanisms, IL-10 and TGF-beta as secreted cytokines, and cytotoxic T lymphocyte antigen 4 and programmed death 1 as surface molecules. Healthy and allergic individuals exhibit all three ...
Purified Native Bovine Bos d 11 (β-casein) Allergen Protein from Creative Biomart. Native Bovine Bos d 11 (β-casein) Allergen Protein can be used for research.
At first, one might think this is a sad story. Can someone actually be allergic to beer? Luckily, it has a happy ending. This tale of woe, comes to us from the journal Allergy. A sad man reported shortness of breath and skin rashes after drinking beer. At first, it sounds like an allergy to everyones favourite fermented beverage. A mans dreams of Oktoberfest debauchery might evaporate like the Angels share. Luckily a team of researchers at the Allergy Unit of the Faenza Hospital, in Italy took pity on this man and went all CSI on his immune system. Allergies to cereal products (i.e. beer) might be due to a nonspecific lipid transfer protein (LTP). With the vast variety of cereals used to make beer, the researchers proposed that only one kind of cereal might contain a LTP responsible for this allergy. This brave - allergic - soul was subject to a vast number of reaction inducing skin puncture tests. His skin was violated with all sorts of beer related allergens and 36 different commercial beer ...
In order to identify antifungal compounds from natural sources to be used as ingredients in the bakery industry, water/salt-soluble extracts (WSE) from different legume flour hydrolysates obtained by the use of a fungal protease were assayed against Penicillium roqueforti DPPMAF1. The agar diffusion assays allowed the selection of the pea (Pisum sativum) hydrolysate as the most active. As shown by the hyphal radial growth rate, the WSE had inhibitory activity towards several fungi isolated from bakeries. The MIC of the WSE was 9.0 mg/ml. Fungal inhibition was slightly affected by heating and variations in pH. The antifungal activity was attributed to three native proteins (pea defensins 1 and 2 and a nonspecific lipid transfer protein [nsLTP]) and a mixture of peptides released during hydrolysis. The three proteins have been reported previously as components of the defense system of the plant. Five peptides were purified from WSE and were identified as sequences encrypted in leginsulin A, ...
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Kendall Tenderskin Hypoallergenic Paper Tape Lightweight, hypoallergenic paper tape for general use. Strong, tangle free, easy to tear. Natural porosity allows skin to breathe. Ideal for use where frequent taping and un-taping are necessary.
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IgE mediated allergy to corn has been documented, in some cases, to relate to heat stable lipid transfer proteins from corn (e.g., Pastorello et al J Allergy Clin Immunol. 2003 Oct;112(4):775-83). However, corn, like any food, is a collection of proteins and the complete array of corn proteins that may be responsible for allergic responses, presumably including labile proteins, has not been established. Based upon studies of other foods and allergens, we know that people may become sensitized to various combinations of proteins, and specific areas of proteins (epitopes), and that the specific pattern of response may be reflected in clinical outcomes. Some proteins of corn would presumably be more stable to processing (e.g., lipid transfer proteins) and digestion than others. Therefore, depending upon a persons corn allergy profile and the processing through which a corn ingredient went, one may predict clinical reactions would occur in some instances and not others. These variables, not ...
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Choosing the best earrings for sensitive ears can be tricky if youre unaware of what to look for. Use this guide with the top hypoallergenic earrings today!
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Find event details and tickets information for Il decision making e i processi di decisione . Event starts at Mon Sep 28 2020 at 05:30 pm and happening at Locarno.
bcFoods Item Allergens feature helps manufacturers and processors keep track of the item allergens that go into their products.
Avoiding allergens during the holidays is important to your health. Learn more about avoiding allergens during the holidays at Discovery Health.