The CD71 antigen is known as the transferrin receptor. It mediates cellular iron uptake via internalization and recycling. It is a type II membrane glycoprotein, characterized as a disulfide-bound dimer of two identical subunits of 95 kDa each. CD71 is expressed on activated T and B lymphocytes, macrophages and erythroblasts. The N-Terminal, intracytoplasmic domain of CD71 mediates rapid endocytosis and self recycling. CD71 is absent from resting blood leucocytes. Its expression is upregulated on proliferating cells. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
The CD71 antigen is known as the transferrin receptor. It mediates cellular iron uptake via internalization and recycling. It is a type II membrane glycoprotein, characterized as a disulfide-bound dimer of two identical subunits of 95 kDa each.
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008 ...
2014.08 『一隻晴朗熊的故事』#廣宇建設. 「晴朗熊」是用 FRP所作成的,作品呼應其「城市遊樂園」概念畫風。. 在擁擠規律、天天步調一樣的城市生活裡,晴朗熊療癒著每個路人,它的存在令人感到溫暖可靠。. 廣宇建設的總經理說「建築就是在創造完美的可能性,用最講究的工藝,締造最好的生活品質」,晴朗熊為這棟建築物帶來了許多的溫暖,當人們經過的時候都忍不住與它爭相合照。. 由於『晴朗熊』是用 FRP所作成的,為了怕影響作品材質,所以塗上鼎鼎集團的「防護牆一號」來進行防護,效果真是好的沒話說!. 還在等什麼~心動不如行動!快來使用鼎鼎集團的「防護牆一號」. 鼎鼎集團的「防護牆一號」保證讓您刮目相看,而且可以綠化環境,降低對地球的傷害!!. #雕塑 #奈米 #鍍膜 #防護#公共藝術 ...
We report here on the primary structure and functional characteristics of the protein responsible for the system A amino acid transport activity that is known to be expressed in most human tissues. This transporter, designated ATA2 for amino acid transporter A2, was cloned from the human hepatoma ce …
1. Bian Z, Guo Y, Ha B, Liu Y (2012) Regulation of the Inflammatory Response: Enhancing Neutrophil Infiltration under Chronic Inflammatory Conditions. J Immunol. 188(2):844-53. Epub 2011 Dec 7.. 2. Zen K, Guo YL, Li LM, Bian Z, Zhang CY and Liu Y (2011) Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood 5;117(18):4885-94.. 3. Chen C, Soto I, Guo YL and Liu Y (2011) Control of secondary granule release in neutrophils by Ral GTPase. J. Biol. Chem. 286(13):11724-33. 4. Zen K, Liu DQ, Li LM, Chen CX, Guo YL, Ha B, Chen X, Zhang ZY, Liu Y (2009) The heparan sulfate proteoglycan form of epithelial CD44V3 serves as a CD11b/CD18 counter-receptor during PMN transepithelial migration. J. Biol. Chem. 284(6):3768-76.. 5. Zen K, Liu DQ, Guo YL, Wang C, Shan J, Fang M, Zhang CY and Liu Y (2008) CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. PLoS ONE. 19;3(3):e1826.. 6. Zen K. ...
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xCT, encoded by the gene SLC7A11, is a member of the heterodimeric amino acid transporter family. Proteins within this family are linked to one another via a
Direct interactions were evident between nerve fibres in the central cornea and epithelial CD11c+ DCs and sub-basal Iba-1+ macrophages. The most distinctive association between nerves and macrophages was noted between stromal Cx3cr1+ Iba-1+ MHC class II+ macrophages and peri-limbal nerve trunks. WT BALB/c mice had a greater number of neuro-immune interactions (2.3±0.3 (mean±SEM)/100µm) than C57BL/6J mice (1.5±0.1/100µm). Lectin staining revealed that macrophage processes intimately interdigitated between Schwann cells. There was no topographical difference in the circumferential distribution (i.e. temporal-nasal, superior-inferior) of macrophage-nerve fibre interactions.. ...
The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT |TEX|$(related\;to\;b^0,\;^+-amino\;acid\;transporter)$|/TEX|. Six members are associated with 4F2hc and one is linked to rBAT. Two additional members were identified as ones associated with unknown heavy chains. The members of heterodimeric amino acid transporter family exhibit diverse substrate selectivity and are expressed in variety of tissues. They play variety of physiological roles including epithelial transport of amino acids as well as the roles to provide cells in general with amino acids for cellular nutrition. The dysfunction or hyperfunction of the members of the heterodimeric amino acid
It should be noted that the functionally defined L-type amino acid transport activities as described in this and many other studies may result from a mixture of functionally similar amino acid transporters that share common features such as Na+ dependence, BCH sensitivity, and neutral amino acid substrate preference. To date, at least four members of this family, LAT1, LAT2, LAT3, and LAT4, have been cloned (Bodoy et al., 2005). LAT1 and LAT2 are heterodimeric transporters that require coexpression of both LAT and 4F2hc for function and exhibit trans-stimulation (Verrey, 2003). In contrast, LAT3 and LAT4 are structurally distinct from LAT1 and LAT2 and are functional independent of 4F2hc (Babu et al., 2003; Bodoy et al., 2005). It has been shown that different LAT subtypes exhibit distinct expression profiles across tissues and species (Verrey, 2003; Bodoy et al., 2005). Moreover, different LAT subtypes show differences in substrate specificity, transport kinetics, and other properties such as ...
CD98 heavy chain (CD98hc) is a multifunctional transmembrane comprising scaffolding proteins whose extracellular website binds with light chain amino acid transporters (Lats) to form the heterodimeric amino acid transporters (HATs). Compact disc98-reliant amino acidity transportation 548-62-9 improved renal tubular epithelial cell expansion by a system that will not really need the Compact disc98hc cytoplasmic end. Both these systems of improved renal tubular epithelial cell expansion are mediated by Erk and g38 MAPK signaling. Although improved amino transportation substantially triggered mTor signaling, this path do not really alter cell expansion. Therefore, these research demonstrate that in IMCD cells, the cytoplasmic and extracellular domain names of Compact disc98hc regulate cell expansion by specific systems that are mediated by common MAPK signaling paths. Intro The heterodimeric amino acidity transporters are made up of Rabbit Polyclonal to CST11 a type II transmembrane proteins ...
CD98 heavy chain (CD98hc) is a multifunctional transmembrane comprising scaffolding proteins whose extracellular website binds with light chain amino acid transporters (Lats) to form the heterodimeric amino acid transporters (HATs). Compact disc98-reliant amino acidity transportation 548-62-9 improved renal tubular epithelial cell expansion by a system that will not really need the Compact disc98hc cytoplasmic end. Both these systems of improved renal tubular epithelial cell expansion are mediated by Erk and g38 MAPK signaling. Although improved amino transportation substantially triggered mTor signaling, this path do not really alter cell expansion. Therefore, these research demonstrate that in IMCD cells, the cytoplasmic and extracellular domain names of Compact disc98hc regulate cell expansion by specific systems that are mediated by common MAPK signaling paths. Intro The heterodimeric amino acidity transporters are made up of Rabbit Polyclonal to CST11 a type II transmembrane proteins ...
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Nuclear Neuroimaging is becoming an important diagnostic tool with increasing impact in neurological and neuro-oncological practice. An emerging use of brain FDG-PET is the early recognition of a potentially treatable cause of rapid progressive dementia. This is the case of Autoimmune Limbic Encephalitis, where brain FDG-PET findings may appear even before characteristic brain MRI hyperintensities. On the other hand, PET is a well-established method in systemic oncology, and is being increasingly used to supplement MRI in the clinical management of brain tumors. The evidence-based recommendation by the PET- Response Assessment in Neuro-Oncology working group (RANO) and the European Association of Neuro-Oncology (EANO) on the clinical use of PET imaging in gliomas, and the recently published joint guidelines of the SNMMI and EANM focusing on radiotracers that are used in clinical practice imaging, i.e. glucose metabolism, 2-deoxy-2-[18F]fluoro-D-glucose (FDG), and system L amino acid transport ...
The IUPHAR/BPS Guide to Pharmacology. L-type amino acid transporter 1 - SLC7 family. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
T Cell Specific Surface Glycoprotein CD28 (TP44 or CD28) - Pipeline Review, H1 2017 Size and Share Published in 2017-06-13 Available for US$ 3500 at Researchmoz.us
The report on the Global T Cell Surface Glycoprotein CD3 Epsilon Chain market offers complete data on the T Cell Surface Glycoprotein CD3 Epsilon Chain market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the T Cell Surface Glycoprotein CD3 Epsilon Chain market. The top contenders Amgen Inc, Celgene Corp, F. Hoffmann-La Roche Ltd, GlaxoSmithKline Plc, MacroGenics Inc, Meridigen Biotech Co Ltd, Numab Innovation AG, SYNIMMUNE GmbH, Tiziana Life Sciences Plc of the global T Cell Surface Glycoprotein CD3 Epsilon Chain market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=20413. The report also segments the global T Cell Surface Glycoprotein CD3 Epsilon Chain market based on product mode and ...
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010 ...
To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) which is approved for the detection of recurrent PCa. Twenty-five hormone-naïve patients with histologically confirmed PCa underwent PET/CT before prostatectomy. Dynamic imaging was performed immediately after injection of 368 ± 10 MBq of 18F-fluciclovine and the uptake in PCa was expressed as SUVmax at six sequential 4-min time frames and as tracer distribution volume (VT) using Logan plots over 0-24 min. The expression of ASCT2 and LAT1 was studied with immunohistochemistry (IHC) on a tissue microarray (TMA) containing three cores per carcinoma lesion. The TMA slides were scored independently by two trained readers based on visual intensity of ASCT2/LAT1 expression on a four-tiered scale. The correlations between ASCT2/LAT1 staining intensity, SUVmax/VT, and
Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. PMID 11901210 ...
The report provides comprehensive information on the T Cell Specific Surface Glycoprotein CD28 (TP44 or CD28), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in T Cell Specific Surface Glycoprotein CD28 (TP44 or CD28) targeted therapeutics development and features dormant and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and ...
Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) ELISA Kit can measure Human T-cell surface glycoprotein CD3 epsilon chain in serum, blood, plasma, cell culture supernatant and other related supernatants and tissues.
No, such switches do not normally happen. Did you specify in any way that you have D-amino acids in you system? This is necessary - even though the standard terms in the force field are symmetric wrt L- and D-amino acids, the CMAP cross terms are different and so you need to use toppar_all36_prot_c36_d_aminoacids.str and the residue names in it; this is in CHARMM, I have no idea about CHARMM-GUI or GROMACS ...
Affiliation:Chubu University,教授, Research Field:Virology,Respiratory organ internal medicine,Virology,Orthopaedic surgery,Orthopaedic surgery, Keywords:FRP-1,CD98,HIV,パラミクソウイルス,パラインフルエンザウイルス,LAT-1,RNAウイルス,ADAM,モノクローナル抗体,細胞融合, # of Research Projects:34, # of Research Products:0
The purpose of this study was to examine the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), an inhibitor of L-type amino acid transporters, on the cell growth suppression in KB human oral cancer cells and to study the roles of cell cycle regulatory factors in the BCH-induced growth inhibition. The effect of BCH on cell growth suppression and the influence of BCH to cell cycle regulatory factors in KB cell growth inhibition were examined using cell cycle analysis, immunoblotting and immunoprecipitation. The BCH treatment induced cell cycle arrest at G1 phase in KB cells. The expression of cyclin D3 was remarkably decreased by BCH treatment. The BCH inhibited the expression of cyclin-dependent protein kinase 6 (CDK6) in a time-dependent manner. In addition, the expression of CDK inhibitor p27 was increased by BCH treatment in KB cells, but not CDK inhibitors p21 and p15. These results suggest that, in KB cells, the inhibition of LAT1 by BCH causes cell cycle arrest at Cl phase ...
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How much of Leucine (Leu or L) α-amino acid is present in Beans, kidney, all types, mature seeds harvested, canned food in details, quantity how high or low Leucine (Leu or L) α-amino acid nutrient content it has.
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Reverse transcription-PCR was performed based on the method of Sugawara et al., 59 with slight modifications, using 1 μg of total RNA isolated from human cornea (kindly provided by Alcon Laboratories, Fort Worth, TX). The forward and reverse primers were 5′-TCT CAC TGC TTA ACG GCG TGT G-3′, and 5′-TCC CTG GCC AAG TCT AAC AAT G-3′, respectively. These primers correspond to the nucleotide positions 110-132 and 606-628 in hLAT1 cDNA, respectively. RT-PCR was performed with a commercial kit (GeneAmp; Applied Biosystems, Foster City, CA). The conditions for reverse transcription were as follows: denaturation of the template RNA for 10 minutes at 70°C and reverse transcription for 60 minutes at 42°C. The conditions for PCR amplification were as follows: denaturation for 1 minute at 94°C; annealing for 1 minute at 58°C, and extension for 1 minute at 72°C, 37 cycles; final extension for 10 minutes at 72°C. The resultant product (∼520 bp) was subcloned in pGEM-T vector and sequenced from ...
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A4GALT encodes a type II membrane glycosyltransferase and results in Pk and P1 antigens of the P Non-ABO blood group along with B3GALNT1. ...
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So I won the pumpkin competition. Yay. To be truthful I won my DIVISION of the pumpkin competition... there were three categories - best dressed, best painted and best carved. And I took best carved. Of course all the other carved pumpkins that had been entered were carved by people to whom I am old enough to have fathered. And, as Rich so astutely stated, joel youre the only person I know who can stay up all night in a cut-throat competition with a five year old. Well...I didnt KNOW they were going to all be five years old, did I! See the fun gals at the Visitors Service Bureau said that it was a tough competition. I thought pumpkins would be coming from all over the mid west. Pumpkins submitted by Madame Tussauds. So I wanted to make sure I stepped up to the plate. To be honest, it was a lot of fun, and everybody made a big fuss about the pumpkins... so it was worth it...AND Janice inspired a brilliant plan which Ill tell you about in a bit. For those of you that wondered - the ...