Clone REAL423 is an antibody fragment derived from the full CD155 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. Clone REAL423 recognizes the mouse CD155 antigen, which is a 70 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. CD155, also known as poliovirus receptor (PVR), belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8+ T cells and natural killer (NK) cells. Mouse CD155 is found on a wide variety of cells of hematopoietic origin, on CD4+ CD8+ thymocytes, regulatory T cells (Tregs), other activated T cells, NKT cells, and at cell junctions on the primary vascular endothelial cells. The REAlease Kits

Exposure of APL as well as non-APL samples to any concentration of As2O3 did not affect the expression of beta2 integrins (CD11a and CD11b), CD45 isoforms (RA, RB and R0), CD44/H-CAM, CD33 and the CEA-related antigen family members CD66ade and CD66b, thus ...

The Taylor R-0007 #7 Thiosulfate Reagent Solution (3/4 ounce bottle is a direct replacement for Thiosulfate Reagents in Taylor test kits.) Test kit reagents should be stored in a cool, dry place out of direct sunlight and should be replaced at lea...

Given the genetic diversity of B-cell lymphomas and differential antigen expression patterns across lymphoma subtypes, it is unlikely that a single small molecule or antibody-based therapeutic will effectively treat all categories of NHL. Therefore, the use of therapeutic antibody combinations targeting different tumor antigens is expected to produce a more robust antitumor response. Simultaneously targeting CD20 and the TNFR family member CD40 may be productive, because both are expressed on the majority of B-cell lymphomas and mediate differential signaling events through their cytoplasmic domains. We evaluated the potential of improving rituximab-based therapies in NHL by targeting CD40 with dacetuzumab. In vivo analysis of the dacetuzumab-rituximab combination in the Ramos NHL xenograft model showed the capacity of dacetuzumab to augment rituximab activity. Potential mechanisms of action behind the ability of dacetuzumab to enhance rituximab activity in vivo include improved recruitment of ...

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008 ...

I just wanted to jump back on these forums, because finally Ill be pursuing treatment (again!) and I need some advice and reassurance. I wrote my history so

The report reviews the competitive landscape and pipeline of antibody-drug conjugates and analyzes R&D stage, targets and drug payloads of ADCs as well as company portfolios.

Antibody-drug conjugates (ADCs) have the potential to elicit an immune response that could impact their PK, efficacy, and safety.

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Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). - Mechanism of Action & Protocol.

The conversion of mesenchyme to epithelium during the embryonic development of the mammalian kidney requires reciprocal inductive interactions between the ureter and the responding metanephric mesenchyme. The Pax-2 gene is activated in the mesenchyme in response to induction and is subsequently down-regulated in more differentiated cells derived from the mesenchyme. Pax-2 belongs to a family of genes, at least three of which encode morphogenetic regulatory transcription factors. In order to determine the role of Pax-2 during kidney development, we have generated a loss- of-function phenotype using antisense oligonucleotides in mouse kidney organ cultures. These oligonucleotides can specifically inhibit Pax-2 protein accumulation in kidney mesenchyme cells, where the intracellular concentrations are maximal. The kidney organ cultures were stained with uvomurulin and laminin antibodies as markers for epithelium formation. With significantly reduced Pax-2 protein levels, kidney mesenchyme cells ...