We report here that joint inflammation in collagen-induced arthritis is more aggravated in CD44-knockout mice than in WT mice, and we provide evidence for molecular redundancy as a causal factor. Furthermore, we show that under the inflammatory cascade, RHAMM (receptor for hyaluronan-mediated motility), a hyaluronan receptor distinct from CD44, compensates for the loss of CD44 in binding hyaluronic acid, supporting cell migration, up-regulating genes involved with inflammation (as assessed by microarrays containing 13,000 cDNA clones), and exacerbating collagen-induced arthritis. Interestingly, we further found that the compensation for loss of the CD44 gene does not occur because of enhanced expression of the redundant gene (RHAMM), but rather because the loss of CD44 allows increased accumulation of the hyaluronic acid substrate, with which both CD44 and RHAMM engage, thus enabling augmented signaling through RHAMM. This model enlightens several aspects of molecular redundancy, which is widely
Previous studies from this laboratory have demonstrated that down-regulation of the standard CD44 isoform at the mRNA and protein level is associated with the acquisition of high metastatic ability within the Dunning R-3327 system of rat prostate cancers. Additional studies demonstrated that transfection-induced enhanced expression of the standard CD44 isoform suppresses the metastatic ability of the AT3.1 Dunning subline without suppressing tumorigenicity. The standard CD44 isoform is a major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronate. In this study, an investigation was made to resolve whether the ability of the standard CD44 isoform to suppress metastasis of the AT3.1 prostate cancer cells critically requires enhanced hyaluronate binding. Highly metastatic Dunning AT3.1 rat prostate cancer cells were transfected with expression plasmids encoding either the wild-type or mutant standard CD44 isoform. The mutant standard CD44 isoform construct encoded a ...
Fibroblasts transformed by Fos oncogenes display increased expression of a number of genes implicated in tumor cell invasion and metastasis. In contrast to normal 208F rat fibroblasts, Fos-transformed 208F fibroblasts are growth factor independent for invasion. We demonstrate that invasion of v-Fos- or epidermal growth factor (EGF)-transformed cells requires AP-1 activity. v-Fos-transformed cell invasion is inhibited by c-jun antisense oligonucleotides and by expression of a c-jun dominant negative mutant, TAM-67. EGF-induced invasion is inhibited by both c-fos and c-jun antisense oligonucleotides. CD44s, the standard form of a transmembrane receptor for hyaluronan, is implicated in tumor cell invasion and metastasis. We demonstrate that increased expression of CD44 in Fos- and EGF-transformed cells is dependent upon AP-1. CD44 antisense oligonucleotides reduce expression of CD44 in v-Fos- or EGF-transformed cells and inhibit invasion but not migration. Expression of a fusion protein between ...
Results RHAMM expression in the subgroup of large cell carcinomas (LCC) was associated with inferior survival (p=0.000223). Median overall survival was 92 versus 18 months for RHAMM-negative and positive patients, respectively. This survival difference remained significant in both nodal negative and positive patients (pN0: p=0.013 and pN≥1: p=0.007, respectively). P-gp expression was associated with inferior survival in adenocarcinomas (ACA; p=0.013) and appeared to be a postsurgical Union International Contre le Cancer (pUICC)- stage and gender-independent prognostic factor, irrespective of adjuvant chemotherapy, in the multivariable analysis; considering nodal status, this survival difference applied to pN0 cancers (p=0.026).. ...
CD44 is a transmembrane glycoprotein, which can exist in a multitude of isoforms due to alternative splicing of the pre-mRNA. We have generated monoclonal antibodies to several of these variant regions, which are encoded by 10 additional exons in the extracellular part of the molecule. CD44 variant isoforms have been reported to be involved in the malignant progression of rat and human tumours. The precise localization of CD44 variant isoforms in normal developmental and morphogenetic processes is essential for diagnostic studies of human tumorigenesis. Therefore, we have analysed a large number of different human tissues by immunohistochemistry for the expression of CD44 isoforms containing either exons 4v, 6v or 9v. Expression of exon 9v-isoforms was detected in almost all epithelia analysed, with a few exceptions. Exon 6v isoforms are expressed only in squamous and glandular epithelial, e.g. skin epidermis, sweat and sebaceous glands, oesophagus, ducts of the mammary gland, salivary and ...
Do you know what to do if an equation doesnt look like y=mx+b?! If not, then this video is for you. Chances are the equation is in standard form,...
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Mouse Monoclonal. Reactivity: Hu, Ms. Application: IHC-P. Specificity: Recognizes a cell surface glycoprotein of 80-95kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.. Package: 100μg. ...
The degree of a monomial is found by adding the exponents together! ... Standard form: Polynomials are usually written in standard form, beginning with the nonzero term of highest degree and continuing with terms in descending order according to degree.
SiR-Kaufmann and colleagues (March 11, p 615) assessthe expression of CD44 isoforms in breast cancer andcorrelate the data with outlook. With antibodies againsthuman CD44 variant isoforms (CD44v), they showsignificant correlations between presence of v6 epitopes andoverall survival. Reactivity against DIII, a polyclonal serum,emerged as an independent prognostic factor in multivariateanalyses, surpassing in risk even such established factors aslymph-node status, tumour size, and histological grading.These workers claim the necessity for further studiesincluding more patients ...
Number Routine use of addition, subtraction, multiplication and division, using integers, decimals and fractions, including order of operations.. Simple positive exponents.. Simplification of expressions involving roots (surds or radicals).. Prime numbers and factors, including greatest common divisors and least common multiples.. Simple applications of ratio, percentage and proportion, linked to similarity.. Definition and elementary treatment of absolute value (modulus), ǀ a ǀ .. Rounding, decimal approximations and significant figures, including appreciation of errors.. Expression of numbers in standard form (scientific notation), that is, a ×10k , 1≤ a ,10.. Sets and numbers Concept and notation of sets, elements, universal (reference) set, empty (null) set, complement, subset, equality of sets, disjoint sets.. Operations on sets: union and intersection.. Commutative, associative and distributive properties.. Venn diagrams.. Number systems: natural numbers; integers; rationals and ...
Files an error against a form element.. When a validation error is detected, the validator calls form_set_error() to indicate which element needs to be changed and provide an error message. This causes the Form API to not execute the form submit handlers, and instead to re-display the form to the user with the corresponding elements rendered with an error CSS class (shown as red by default).. The standard form_set_error() behavior can be changed if a button provides the #limit_validation_errors property. Multistep forms not wanting to validate the whole form can set #limit_validation_errors on buttons to limit validation errors to only certain elements. For example, pressing the Previous button in a multistep form should not fire validation errors just because the current step has invalid values. If #limit_validation_errors is set on a clicked button, the button must also define a #submit property (may be set to an empty array). Any #submit handlers will be executed even if there is invalid ...
Ettekande slaidid. [pdf]. Abstract: Designing a viable language for total (as in type theory) functional programming is remarkably difficult: it takes a term calculus for a type language with inductive and coinductive types that is satisfactory both metatheoretically and practically. Basic structured (co)recursion schemes in their standard form are not an option, they are far too cumbersome to program with.. The alternatives include what are known as guarded and Mendler-style (co)recursion primitives. These are general-recursor like combinators. Guarded combinators are governed by syntactic side-conditions enforcing conformance of an a priori general-recursive definition to a structured (co)recursion scheme. Mendler-style combinators are cleaner: here the same effect is achieved by more restrictive typing employing universal quantification. But a problem with both is that the choice of the structured (co)recursion scheme to support is non-canonical.. We argue that one meaningful canonical ...
Given a tanru which expresses an idea to be used frequently, it can be turned into a lujvo by following the lujvo-making algorithm which is given in Section 4.11.. In building a lujvo, the first step is to replace each gismu with a rafsi that uniquely represents that gismu. These rafsi are then attached together by fixed rules that allow the resulting compound to be recognized as a single word and to be analyzed in only one way.. There are three other complications; only one is serious.. The first is that there is usually more than one rafsi that can be used for each gismu. The one to be used is simply whichever one sounds or looks best to the speaker or writer. There are usually many valid combinations of possible rafsi. They all are equally valid, and all of them mean exactly the same thing. (The scoring algorithm given in Section 4.12 is used to choose the standard form of the lujvo - the version which would be entered into a dictionary.). The second complication is the serious one. Remember ...
D. Berfau - Verbs 1. The Present Tense All verb -nouns are added to various persons of the verb to be - linked by yn. There is no mutation after this linking yn. (a) The Affirmative forms Standard forms
We applied our factoring skills to convert quadratic equations in Standard Form ($latex y=ax^2+bx+c $) to Factored Form ($latex y=a(x-r)(x-s) $). Its the same process as weve been using for factoring expressions, but theres an extra step at the end to factor out any coefficients on the linear terms. For example, if you factor an…
If you spend $1,000 for something you could have bought for $800, youll need to produce an extra $200 to make up for it. Make this easy on yourself by using a standard form to solicit bids on purchase over a certain amount. E-mail it to at least three vendors, with a tight deadline for their bid. Youll be surprised how well this works. I once saved more than $4,000 on a car purchase with just this method. Even better, I saved hours of time I would have spent driving to each dealership and dealing with the whole sales pitch hassle. ...
Write the standard form of the ellipse x^2+4y^2+6x-8y+9=0 Im not sure how to start it, I think I need to set it equal to one because eventually it needs to end up equal to one but Im not certain. I know the answer is (x+3)^2/4 + (y-1)^2/1=1 but have no idea how to get there... ...
If you record wma or mp3 files directly to the CD without choosing AUDIO CD, your CD will be recorded as a Data CD, and only players capable of decoding those files will be able to play your talks, and the CD that you make will not be playable in a standard CD player ...
If you record wma or mp3 files directly to the CD without choosing AUDIO CD, your CD will be recorded as a Data CD, and only players capable of decoding those files will be able to play your talks, and the CD that you make will not be playable in a standard CD player ...
A number of reports have shown that CD44 is present in cholesterol-enriched lipid raft microdomains in various cell types including T cells (Ilangumaran et al., 1998; Gómez-Móuton et al., 2001; Oliferenko et al., 1999; Seveau et al., 2001; Pierini et al., 2003; Bourguignon et al., 2004). However, the functional significance of CD44 localization in the lipid rafts had been largely unknown. This study demonstrated the functional significance of this association in T cell adhesion properties. We demonstrated in the present study that cellular cholesterol modulates the HA-binding ability of CD44. Using BW5147 T cells, which express CD44 with HA-binding ability, we showed that cholesterol depletion induced with MβCD upregulates both the HA-binding ability of CD44 (Fig. 1) and the loss of CD44 from detergent-insoluble fractions (Fig. 3). We also found that cholesterol oxidation and sequestration upregulate CD44s HA-binding ability (Fig. 2), suggesting that the lipid rafts modulate CD44 function. ...
Cancer stem cells (CSC) play an important role in pancreatic carcinogenesis and prognosis. The study aimed at examining the expression of CD24, CD44, and CD133 in human PDAC and CP in order to evaluate its clinicopathological correlations and the clinical significance. Surgical specimens from 23 patients with PDAC and 15 patients with chronic pancreatitis after pancreatic resection were stained with CD24, CD44, and CD133 antibodies. The intensity of staining was scored from 0 (negative) to 3 (strongly positive). Results. Mean CD24 staining score in PDAC was 1.38 ± 0.76 and was significantly higher than that in CP: 0.70 ± 0.53 (p | 0.01); CD44 score in PDAC was 2.23 ± 0.42 and was significantly higher than that in CP: 1.87 ± 0.55 (p | 0.05); CD133 score 0.93 ± 0.58 was not different from CP: 0.71 ± 0.43 (p | 0.05). CD44 immunoreactivity was significantly higher (p | 0.05) in pT1 and pT2 patients together as regards pT3: 2.45 ± 0.37 versus 2.06 ± 0.38 as well as in N0 patients compared to N1
Irish is recognised by the Constitution of Ireland as the national and first official language of the Republic of Ireland (English is the other official language). Despite this, almost all government debates and business are conducted in English.[21] In 1938, the founder of Conradh na Gaeilge (Gaelic League), Douglas Hyde, was inaugurated as the first President of Ireland. The record of his delivering his inaugural Declaration of Office in Roscommon Irish is one of only a few recordings of that dialect.[22][23][24][25] In the 2016 census, 10.5% of respondents stated that they spoke Irish, either daily or weekly,[26] while over 70,000 people speak it as a habitual daily means of communication. From the foundation of the Irish Free State in 1922 (see also History of the Republic of Ireland), a degree of proficiency in Irish was required of all those newly appointed to the Civil Service of the Republic of Ireland, including postal workers, tax collectors, agricultural inspectors, Garda Síochána, ...
Irish was spoken as a community language in Irish towns and cities down to the 19th century. In the 16th and 17th centuries it was widespread even in Dublin and the Pale.[56]. The Irish of Dublin, situated as it was between the east Ulster dialect of Meath and Louth to the north and the Leinster-Connacht dialect further south, may have reflected the characteristics of both in phonology and grammar. In County Dublin itself the general rule was to place the stress on the initial vowel of words. With time it appears that the forms of the dative case took over the other case endings in the plural (a tendency found to a lesser extent in other dialects). In a letter written in Dublin in 1691 we find such examples as the following: gnóthuimh (accusative case, the standard form being gnóthaí), tíorthuibh (accusative case, the standard form being tíortha) and leithscéalaibh (genitive case, the standard form being leithscéalta).[57]. English authorities of the Cromwellian period, aware that Irish ...
A study from the Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA; and Womens Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA shows that: "Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice." This study was published in the 03 October 2016 issue of the journal "Nature Medicine" by Prof. Noble PW, Liang J and others.. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Pulmonary Fibrosis: Onion Peel extract (OPE) increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down-regulation of its target gene. Significance:. Given that: (1) Pulmonary disease (PD)/Pulmonary fibrosis (PF) is a progressive ...
A major component of the extracellular matrix is hyaluronan, a regulator of cell migration/survival and differentiation during response-to-injury processes. The receptor for hyaluronan-mediated motility (RHAMM) binds to HA and has limited constitutive expression but is upregulated during tissue injury. Blocking HA fragment:RHAMM interactions has therapeutic potential for treating cancer but truncation of RHAMM into peptides mimicking only the HA binding domains is predicted to lose their natural α-helical structure. The goal of this project is to explore the effects cyclizing each binding domain has on helicity and its biological effect. Eighteen peptides were synthesized and cyclized using lactam bridges. The peptides were analyzed by circular dichroism spectroscopy and one stapled peptide exhibited a 4-fold increase in helicity compared to the unstapled sequence and significantly decreased migration, inflammation, and fibrosis in vitro. This cyclic peptide is a novel protein-carbohydrate inhibitor
In this study we demonstrate that LC and DC during in vitro activation and during their in vivo migration to the peripheral LN differentially upregulate pan CD44 epitopes and sequences encoded by variant exons CD44v4, v5, v6, and v9. Thus LC and DC activation or migration is accompanied by increased synthesis of CD44 and by a change of either epitope accessibility or splicing. The mechanisms underlying this change remain to be elucidated: granulocyte macrophage colony stimulating factor (GM-CSF), tumor necrosis factor-α, and interleukin-1β, secreted by keratinocytes in response to antigen application to the skin, play a role in LC-maturation, emigration, and accumulation in LN (9, 11, 16). Furthermore, the generation of activated DC from peripheral blood precursors depends upon the presence of GM-CSF (35). However, at present we have no evidence that GM-CSF and tumor necrosis factorα are involved in CD44 modulation by LC or DC, since biologically active mAbs neutralizing these cytokines added ...
Having crossed from chimpanzees to humans in only the past century, HIV-1 has rapidly evolved a daunting degree of diversity, posing a considerable challenge for vaccine development. The definition of naturally occurring broadly neutralizing antibodies (NAbs) has proven elusive, and the ability to target conserved determinants of the viral envelope (Env) has proven difficult (1, 2). During HIV-1 infection, almost all individuals produce antibodies to Env, but only a small fraction can neutralize the virus (1, 2). Recently, several groups have shown that the sera of 10 to 25% of infected participants contain broadly reactive NAbs (3-6), including some sera that neutralize the majority of viruses from diverse genetic subtypes (5-7). NAbs react with the HIV-1 Env spike, which is composed of three heavily glycosylated glycoprotein (gp)120 molecules, each noncovalently associated with a transmembrane gp41 molecule. To initiate viral entry into cells, the gp120 binds to the cell surface receptor CD4 ...
Compare hyaluronic acid binding protein 2 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
The CD44 antigens are transmembrane glycoproteins and members of the hyaladherin family of hyaluronan-binding proteins. Multiple CD44 isoforms have been described, the predominant form being CD44S, a glycoprotein of 85 kDa. CD44 is present on most cells or tissues, but not on platelets, hepatocytes, cardiac muscle, kidney tubular epithelium, testis and skin portions. The human blood group antigens Ina/b reside on CD44. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Equations for the probability functions are given for the standard form of the distribution. Formulas exist for defining the functions with location and scale parameters in terms of the standard form of the distribution. The sections on parameter estimation are restricted to the method of moments and maximum likelihood. This is because the least squares and PPCC and probability plot estimation procedures are generic. The maximum likelihood equations are not listed if they involve solving simultaneous equations. This is because these methods require sophisticated computer software to solve. Except where the maximum likelihood estimates are trivial, you should depend on a statistical software program to compute them. References are given for those who are interested. Be aware that different sources may give formulas that are different from those shown here. In some cases, these are simply mathematically equivalent formulations. In other cases, a different parameterization may be used ...
Textbook solution for Multivariable Calculus 8th Edition James Stewart Chapter 12.6 Problem 31E. We have step-by-step solutions for your textbooks written by Bartleby experts!
Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear. We examined the CD168 expression of 196 consecutive gastric cancer patients by immunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into two groups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression and clinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluated according to the Japanese Classification of Gastric Carcinoma. Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity was
The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Abnormal CD45 splicing has been recognized in humans, caused by a C77G transversion in the gene encoding CD45 (PTPRC). Recently the C77G polymorphism has been associated with multiple sclerosis and increased susceptibility to HIV-1 infection. These studies suggest that the regulation of CD45 splicing may be critical for the proper function of the immune system. Because of these data we examined the frequency of the C77G allele in African and Asian populations from countries with high or low prevalence of HIV infection. Here we report that the variant CD45 C77G allele is absent in African populations. We further show that populations living in the Pamir mountains of Central Asia have a very high prevalence of the C77G variant.
Su, J., and J. Forman. CD8 T cells in MHC class Ia-deficient mice. AAI, Denver, CO, 2003. Su, J., R. E. Berg, S. Murry, and J. Forman. Thymus dependent MHC non class Ia selected memory phenotype CD8 T cells from naïve mice provide rapid protection against infection. AAI, San Diego, CA, 2005. xiii List of Figures 1. An elevated percentage of CD8 T cells in DKO are CD8?+CD8?-………………………….50 2. There are less CD8??CD44hi cells and similar CD8?? cells in DKO mice compared to B6 mice…………………………………………………………………………………………..52 3. A significant portion of CD8?? T cells in DKO mice is CD44hiCD122+Ly6C+ and CD62Llo……………………………………………………………………………...............53 4. Expression of NK cell markers by CD8??CD44hi cells from naïve B6 and DKO mice ………………………………………………………………………………………………..55 5. ...
We urgently need patient advocates to be involved in clinical studies, not as researchers, but as patient representatives who are well acquainted with the reality of the patients situation.. Clinical Studies From A Patient Perspective - Interview with Markus Wartenberg, Co-Chair of SPAEN. Clinical studies are an essential step in the development of novel treatment methods for cancer and other diseases. They show researchers what works for the welfare of patients and what does not. In addition to safety and effectiveness they also determine whether the side effects of a new treatment are acceptable and, increasingly, what quality of life for patients is associated with a new therapy. Clinical studies are an important component of treatment concepts for rare forms of cancer because here the standard forms of therapy are often limited. Nevertheless, only up to 5 % of cancer patients actually participate in clinical studies. Recent studies show that 3 out of 5 phase III studies are not able to ...
G43a1 modified to contain SEP (phosphoserine), TPO (phosphothreonine), and PTR (phosphotyrosine) (all PO4^{2-} forms), and SEPH, TPOH, PTRH (PO4H^{-} forms). The charges and vdw parameters come from Hansson, Nordlund and Aqvist jmb 265 118-27 1997. They worked mostly with gromos 87 but I generally use gromos 96 so I\ve made the files in that format (there seem to be no differences in the amino acid charges between 87 and 96). Hansson et al don\t report bond angle or dihedral parameters, and I don\t know how to do QM calculations, so I\ve used the standard forms from the *bon.itp file. For the dihedrals, I\ve used the 3-fold gd_11. Because of their symmetry, the PO4^{2-} forms at least cannot have the 2-fold + 3-fold symmetry used in the gmx DNA bases. The OP-X LJ-14 parameters are the same as for OA. I\ve checked that I can build simple 1-molecule topologies and tprs for the PO4H forms, and for the PO4 forms have done 100 ps solvated MD of the isolated am acs and the am acs in proteins ...
Dutch, along with German, English, Frisian, Danish, Swedish, Norwegian, and Afrikaans, is a Germanic language. It is very closely related to the dialects of northern Germany known as Low German. Indeed, the traditional dialects along the Dutch-German border are virtually the same. You may want to read about the linguistic situation in the lower Rhine area or about spelling variations there. Dutch words for nouns (persons, places, and things) are classified as either common or neuter. Variant Forms of Words In Dutch, as in English, the forms of some words will vary according to how they are used in a sentence. Who-whose-whom, or marry-marries-married are examples of words in English with variant forms. This word list gives the standard form of each Dutch word. As you read Dutch records, you will need to be aware that some words vary with usage. The prefix tis equal to the Dutch word het, which means the. The prefixs- is a part of many place-names and means des (of the). All prefixes are ...
The evidence at trial establishes that the application of the Act has been in compliance with its statutory framework, and that CIRM and the ICOC are operating in the same fashion as other state agencies. Each ICOC member, and each alternate, has taken the oath of office and publicly filed Form 700, the standard form California public officials file to disclose financial holdings. The ICOC developed and adopted incompatible activities statements, the conflict of interest code required by the Political Reform Act, and conflict of interest policies for ICOC members, CIRM staff, and members of each of the ICOC advisory groups. Between January 2005 and the date of the trial, the ICOC, its subcommittees, and its working groups held over 40 noticed, public meetings, in cities across the state, held pursuant to the Bagley-Keene Open Meeting Act. CIRM has responded to numerous Public Records Act requests. The selection of the site for the CIRMs facilities was run by the Department of General Services, ...
A Modular Operating Topology Element (MOTE) is provided within a software-latticed networked topology for implementing ultra-concurrent operation of a plurality of such elements, as a single miniaturized package having a prevailing standard form, e.g., Compact Flash, with an embedded a full function processor (CPU), a unique resident operating system, and dedicated applications. The external interface projects a virtual mass storage volume. A MOTE selectively acts as an ultra-modular processor, operating with ultra-concurrency, with the CPU internally bus connected to non-volatile RAM, dedicated non-volatile ROM (firmware), a dedicated battery-backed real-time clock-calendar unit, and a dedicated interrupt monitor unit. Internally accessed data and internal applications stored in ROM or in non-volatile RAM are invisible to the outside. Optional input/output devices may be connected to the internal hardware bus. A host external bus connection is provided for mass storage volumes, which support file-level
I can get part of the answer then I get stumped. find the center and radius of the circle, Write the standard form of the equation. (4,3)(1,3) to get center: (1+4/2, 3+3/2)=5/2,3 answer:5/2,3 for center radius: then i am stuck ...
REFER A PATIENT Thank you for referring your patient to us. If you prefer, you may call 800-888-5533 to refer patients via the UK-MD phone line. Department-specific referral forms If referring a patient to one of the areas below, complete and submit the department-specific form only. You do not need to complete the standard form.
For pharmaceutical and nutraceutical applications, the ALU-LOOK™ blister films offer a versatile, high-speed packaging option compared with cold-form foil and aluminum strip packaging. Metallic look helps ensure shelf life and protect contents. Runs on all standard form/fill/seal blister machinery with no processing parameter changes necessary ...
So you are wanting to do 6 total sets for your back? In that case how about 3 bent over rows, 2 pulldowns/pullups/chins, and 1 rear delt row. The thing with bent over rows is if you bend more and lift the bar further up like just below the pecs, it doesnt get the lats much, but it hits the rear delts pretty hard. If you stand up a little higher then normal and go just above the waist, it is more of a lat exercise, doesnt get the rear delts much, and does a bit less for the traps. It is a versatile exercise that can be done different ways for different goals. In my example I suggest the standard form ...
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Hyaluronan is a negatively charged polydisperse polysaccharide where both its size and tissue concentration play an important role in many physiological and pathological processes. The various functions of hyaluronan depend on its molecular size. Up to now, it has been difficult to study the role of hyaluronan in diseases with pathological changes in the extracellular matrix where availability is low or tissue samples are small. Difficulty to obtain large enough biopsies from human diseased tissue or tissue from animal models has also restricted the study of hyaluronan. In this paper, we demonstrate that gas-phase electrophoretic molecular mobility analyzer (GEMMA) can be used to estimate the distribution of hyaluronan molecular sizes in biological samples with a limited amount of hyaluronan. The low detection level of the GEMMA method allows for estimation of hyaluronan molecular sizes from different parts of small organs. Hence, the GEMMA method opens opportunity to attain a profile over the ...
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Buy anti-HMMR antibody, Rabbit HMMR / CD168 / RHAMM Polyclonal Antibody-NP_036616.2 (MBS243539) product datasheet at MyBioSource, Primary Antibodies. Application: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Complete information for FKBPL gene (Protein Coding), FK506 Binding Protein Like, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium