CD43/Sialophorin Antibodies available through Novus Biologicals. Browse our CD43/Sialophorin Antibody catalog backed by our Guarantee+.

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene. Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome. It also appears in about 25% of intestinal MALTomas.[citation needed] Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell ...

Mouse Monoclonal Anti-CD43/Sialophorin Antibody (W3/13) [DyLight 488]. Validated: Flow, IHC-Fr, IHC-P. Tested Reactivity: Rat. 100% Guaranteed.

Promab CD106 - This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different

Promab CD106 - This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different

Supplier: ProMab Technologies Type of Product: Monoclonal Antibody Description: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may

Adenoidal tissue (also known as nasopharyngeal tonsils) of 58% of humans in the pediatric age group contains immature T-lymphoid cells with the phenotype of thymocytes (TdT+, CD1abc+, cytoplasmic CD3 ...

|strong|Rat anti Human CD235a antibody, clone YTH89.1|/strong| recognizes glycophorin A, a major sialoglycoprotein of the human erythrocyte membrane.

Topeka-Today, Kansas legislators in both the House and Senate introduced a resolution condemning New Yorks Reproductive Health Act passed on January 22nd that allows some abortions up to the moment of birth-and strips even infants born alive of a right to basic medical care.. The resolution affirms that the people of Kansas seek to protect all life from the moment of conception. It further condemns the state of New York for coopting the Freedom Towers, a national symbol of Freedom, in its celebration of death-even as the preborn lives who died in the September 11, 2001 terrorist attacks are honored beneath the Tower on the September 11th Memorial.. A Statement from Brittany Jones, Esq., Advocacy Director for Family Policy Alliance of Kansas:. The New York abortion law is a horrific reflection on the state and its values. Even as several more states consider following New Yorks lead, Kansas is proud to be a state that cherishes life and provides some of the strongest prolife protections in the ...

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Definition: D2-40 is a monoclonal antibody recognizing podoplanin , a 40 000 kD O-linked sialoglycoprotein located in lymphatic endothelial (...)

Glycophorins are a family of human erythrocyte membrane glycoproteins. At least four different sialoglycoproteins glycophorins, A (or α), B (or δ), C (or β) and D (or γ) have been detected in humans. Glycophorin A is the major sialic acid-containing protein of human erythrocyte membranes. It consists of 131 amino acids distributed in three structural domains. Glycophorin A is encoded by a single gene which gives rise to three different mRNAs, large (2.8 kb ), medium (1.7 kb) and small (1.0 kb) in reticulocytes and in K562, a human erythroleukaemia cell line expressing glycophorin A on its surface. -- Six clones were isolated from a cDNA library constructed with K562 cell mRNA in λgt10 phage using as a probe a synthetic oligonucleotide (GPA-N2) encoding amino acid numbers 30 to 40 of glycophorin A. Nucleotide sequencing of the six clones revealed that all contain an identical protein coding region except for the well known glycophorin AM-AN polymorphism and essentially identical 5 ...

generating the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in ...

Glycophorins are the major sialoglycoprotein component of erythrocyte cell membranes. They are heavily glycosylated and rich in sialic, making the erythrocytes membranes very hydrophilic. This property enables them to circulate without adhering to other cells or the walls of blood vessels. Glycophorins are classified based on the quantity present in the cell membrane. Glycophorin A is the most abundant. The N-terminal glycosylated segment of glycophorin A, which lies outside the erythrocyte membrane, bears MN blood group receptors. It is encoded by the GYPA gene in humans, and many variants exist due to recombination between the GYPA and GYPB genes. Glycophorin A contains a receptor for binding the malaria parasite Plasmodium falciparum; it also binds several viruses. Glycophorin A is also known as sialoglycoprotein alpha, MN sialoglycoprotein, CD235a antigen, MN, GPA, MNS, GPSAT, PAS-2, CD235a, GPErik, HGpMiV, HGpMiXI, and HGpSta(C).. ...

Glycophorins are the major sialoglycoprotein component of erythrocyte cell membranes. They are heavily glycosylated and rich in sialic, making the erythrocytes membranes very hydrophilic. This property enables them to circulate without adhering to other cells or the walls of blood vessels. Glycophorins are classified based on the quantity present in the cell membrane. Glycophorin A is the most abundant. The N-terminal glycosylated segment of glycophorin A, which lies outside the erythrocyte membrane, bears MN blood group receptors. It is encoded by the GYPA gene in humans, and many variants exist due to recombination between the GYPA and GYPB genes. Glycophorin A contains a receptor for binding the malaria parasite Plasmodium falciparum; it also binds several viruses. Glycophorin A is also known as sialoglycoprotein alpha, MN sialoglycoprotein, CD235a antigen, MN, GPA, MNS, GPSAT, PAS-2, CD235a, GPErik, HGpMiV, HGpMiXI, and HGpSta(C).. ...

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Principal Investigator：WATANABE Kenji,渡辺 乾二, Project Period (FY)：1993 - 1994, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：Zootechnical science/Grassland science

Rabbit polyclonal Ezrin / Radixin / Moesin antibody validated for WB, ELISA, IHC and tested in Human and Mouse. Immunogen corresponding to synthetic peptide

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TY - JOUR. T1 - Purification and characterization of a human sialoglycoprotein antigen expressed in immature thymocytes and fetal tissues. AU - Cecco, L.. AU - Bond, H. M.. AU - Bonelli, P.. AU - Tuccillo, F.. AU - Cerra, M.. AU - Tassone, P.. AU - Sorice, R.. AU - Lamberti, A.. AU - Morrone, G.. AU - Venuta, S.. PY - 1998. Y1 - 1998. N2 - The monoclonal antibody UN1 was previously produced in our laboratory on the basis of selective reactivity with human thymocytes and has been classified as unclustered by the 5th and 6th International Work shop and Conference on Human Leukocyte Differentiation Antigens. The antigen recognized by mAb UN1 was found to be expressed on the cell surface of immature human thymocytes, a subpopulation of peripheral T lymphocytes and on several fetal tissues including thymus. The UN1 antigen is purified from childrens thymus by ionexchange and affinity chromatography. Two-dimensional electrophoresis shows that the purified antigen displays microheterogeneity appearing ...

An integral sialoglycoprotein with Mr approximately 130,000 (Sgp 130) and highest expression in adult chicken gizzard smooth muscle has been recently identified as an excellent candidate for classification as a plasma membrane protein natively associated (directly or indirectly) with actin microfilaments (Rogalski, A.A., and S.J. Singer, 1985, J. Cell Biol., 101:785-801). In this study, the relative in situ distributions of the Sgp 130 integral species (a designation that also includes non-smooth muscle molecular forms) and the peripheral protein, vinculin, have been simultaneously revealed for the first time in selected cultured cells and tissues abundant in microfilament-membrane attachment sites, particularly, smooth and cardiac muscle. Specific antibody probes against Sgp 130 (mouse mAb 30B6) and vinculin (affinity-purified rabbit antibody) were used in double indirect immunofluorescent and immunoelectron microscopic experiments. In contrast to the widespread distributions of vinculin at ...

Description: This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins ...

What is Wiskott-Aldrich syndrome? Wiskott-Aldrich syndrome results in greater susceptibility to infections and abnormal bleeding. The latter occurs due to unusually small, dysfunctional platelets. What is the treatment for Wiskott-Aldrich syndrome? This condition is often cured by stem transplantation from bone marrow, peripheral blood, or cord blood.

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