TY - JOUR. T1 - Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition of bim. AU - Yang, Jin Ming. AU - ONeill, Peter. AU - Jin, Wei. AU - Foty, Ramsey. AU - Medina, Daniel J.. AU - Xu, Zude. AU - Lomas, Mehnaaz. AU - Arndt, Greg M.. AU - Tang, Yi. AU - Nakada, Marian. AU - Yan, Li. AU - Hait, William N.. PY - 2006/4/7. Y1 - 2006/4/7. N2 - Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival of malignant cells and confers resistance to some chemotherapeutic drugs. However, the molecular mechanisms underlying the actions of EMMPRIN are not fully understood. In this study we sought to determine whether EMMPRIN contributes to the malignant phenotype of breast cancer by inhibiting anoikis, a form of apoptosis induced by loss or alteration of ...
Introduction: We have shown that interleukin (IL)-18 plays a role in myocardial injury and remodeling via induction of matrix metalloproteinases (MMPs) and other proinflammatory cytokines. Since the matricellular protein EMMPRIN (basigin/CD147) is a potent inducer of MMPs, we investigated if IL-18 and EMMPRIN expression is cross-regulated, and whether IL-18-induced MMP9 expression is EMMPRIN-dependent.. Methods and results: IL-18 potently induced EMMPRIN expression and secretion in adult mouse cardiomyocytes (ACM; inhibited by IL-18 neutralizing antibodies and IL-18BP-Fc). IL-18 stimulated both Sp1 and NF-κB activations in ACM. In neonatal mouse cardiomyocytes (NMCM), IL-18 stimulated EMMPRIN promoter activity was inhibited by mithramycin and over-expressed mutant Sp1, but not by dominant negative (dn) p65, dnIκB-α, or kdIKKβ. Mutation of the Sp1 binding sites blunted IL-18-stimulated EMMPRIN promoter activity. Transduction with adenoviral dominant negative constructs showed that IL-18 ...
CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function ...
(2010) Mishra et al. Reproductive Biology and Endocrinology. Background: Extracellular matrix metalloproteinase inducer (EMMPRIN) regulates several biological functions involving the modulation of cell behaviors via cell-cell and cell-matrix interactions. According to its diverse functions, we hy...
In the current study, we observed that pelvic lymph node metastases, which represent the tumor invasion and metastatic capability, were significantly associated with EMMPRIN overexpression. These results suggest that EMMPRIN expression in cervical cancer is associated with tumor invasion and metastasis. Our results are consistent with the previous reports of the roles of EMMPRIN in tumor progression (14), including gliomas (15), hepatoma (16), squamous cell carcinoma (17), and melanoma (18, 19). Furthermore, EMMPRIN was shown to be the most frequently expressed protein in primary tumors and in micrometastatic cells (20), and EMMPRIN score was significantly correlated with nodal stage (14), suggesting a central role in tumor progression and early metastasis. To our knowledge, this is the first study that investigates the expression of EMMPRIN and its clinical significance in radiotherapy outcome in cervical carcinoma. Interpretation of the results is aided by the homogeneous radiotherapy before ...
Polyclonal antibody for 575 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. 575 information: Molecular Weight: 42200 MW; Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Melanosome
Goat Polyclonal Anti-EMMPRIN/CD147 Antibody [Unconjugated]. Validated: WB, Simple Western, IHC. Tested Reactivity: Human. 100% Guaranteed.
Among other proteinases such as serine, cysteine, and aspartate proteinases, matrix MMPs have been shown to be essential for degradation of articular matrix as they not only cleave extracellular matrix components10 but also cleave each other, resulting in a domino effect of MMP propeptide and MMP activation.10 This is further supported by recently discovered extracellular MMP inducers that are closely associated with MMP-1 and MMP-3 synthesis in RA-SF.11 In total, about 20 members of the growing family of matrix MMPs are currently known (MMPs 1-3, 7-17, 19-21, 23, and 24), of which some belong to membrane-type (MT) MMPs-for example, MT1-MMP (MMP-14) and MT3-MMP (MMP-16) and to the MMP subfamily of aggrecanases.2. Numerous researchers have provided a large body of data showing that MMP-1 and MMP-3 are most important for joint destruction in RA.10 The present study underlines this hypothesis by associating MMP-1 and MMP-3 expression directly with a functional parameter-that is, the number of cells ...
H-ras transformed human bronchial epithelial cells (TBE-1) secrete a single major extracellular matrix metalloprotease which is not found in the normal parental cells. The enzyme is secreted in a latent form which can be activated to catalyze the cleavage of the basement membrane macromolecule type IV collagen. The substrates in their order of preference are: gelatin, type IV collagen, type V collagen, fibronectin, and type VII collagen; but the enzyme does not cleave the interstitial collagens or laminin. This protease is identical to gelatinase isolated from normal human skin explants, normal human skin fibroblasts, and SV40-transformed human lung fibroblasts. Based on this ability to initiate the degradation of type IV collagen in a pepsin-resistant portion of the molecule, it will be referred to as type IV collagenase. This enzyme is most likely the human analog of type IV collagenase detected in several rodent tumors. Type IV collagenase consists of three domains. Type IV collagenase ...
Photoreceptor nuclei were visualized with an antibody against elav, a neuron-specific nuclear protein. Normally, photoreceptor nuclei lie in tight rows across the eye (e.g. Fig. 6C), so that any mislocalization is readily detected. The nuclei of the R1-R6 photoreceptors lie in the apical region of the retina (Fig. 6C). The nuclei of the R7 photoreceptors are just proximal to those of R1-R6 and the R8 nuclei lie near the basement membrane of the retina (Fig. 6C).. Photoreceptor nuclei of mosaic flies mutant in the eye for the hypomorphic P1096 allele, which encodes a nuclear β-gal, were visualized with anti-β-gal (Fig. 5A). Most nuclei were properly located, although a few nuclei were misplaced (Fig. 6A). We saw similar results for these mosaics with anti-elav (not shown). In mosaics that are mutant in the eye for the bsgδ265 excision allele, elav immunolabeling revealed that 16-50% of photoreceptor nuclei were mislocalized (Fig. 6B). Nuclei were counted as misplaced only if they were ...
Shop Basigin ELISA Kit, Recombinant Protein and Basigin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The expression of EMMPRIN and its role in regulating stromal MMP expression have been extensively studied in various cancer types (2, 5-11, 18-20). The signaling events downstream of EMMPRIN-mediated tumor-host interactions that result in stimulation of MMP production are not yet fully established. The p38 MAPK has been implicated in inducing MMP-1 production (21); similarly, signaling through 5-lipooxygenase and phospholipase A2 may contribute to MMP-2 production (22). Recently, EMMPRIN has been shown to also participate in other activities during cancer progression not directly related to its function as a MMP stimulator (1). For example, EMMPRIN has been shown to potentiate tumor cell anchorage-independent growth (23), a phenomenon that is characteristic of malignant cancer cells, and may be related to multidrug resistance in cancer cells (24). These effects of EMMPRIN were shown to depend on stimulation of production of hyaluronan, a pericellular polysaccharide (23, 24), and cell survival ...
EMMPRIN down-regulation by scFv-M6-1B9 intrabody affecting decline of CEA level. Caco-2 cells transduced for 7 days and 10 days were collected as the supernatan
Mouse CD147 / EMMPRIN / Basigin derived in Human Cells. The whole cell lysate is provided in 1X Sample Buffer.Browse all transfected cell lysate positive controls
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
Can our products be used on different species? The simple answer is yes. BSG offers distinct and diverse separations tools that work with virtually all species. Read to learn more.
Farm leaders in Northern Ireland are pushing government officials to apply for a change in BSE status in a bid to increase beef prices. The Ulster Farmers
TY - JOUR. T1 - Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention. AU - Gwinn, William M.. AU - Damsker, Jesse M.. AU - Falahati, Rustom. AU - Okwumabua, Ifeanyi. AU - Kelly-Welch, Ann. AU - Keegan, Achsah D.. AU - Vanpouille, Christophe. AU - Lee, James J.. AU - Dent, Lindsay A.. AU - Leitenberg, David. AU - Bukrinsky, Michael I.. AU - Constant, Stephanie L.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon interaction of cyclophilins with the cell surface signaling receptor CD147. Elevated levels of extracellular cyclophilins have been documented in several inflammatory diseases. We propose that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses. In this study, we examined whether extracellular ...
Basigin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition (Miyauchi et al., 1991; Kanekura et al., 1991).[9][10] It has a variety of functions. In addition to its metalloproteinase-inducing ability, basigin also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes.[6] Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.[11][12][13] It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes. The human basigin protein contains 269 amino acids that form two heavily ...
Blog on BSG elisa kit product: The Human BSG bsg (Catalog #MBS701560) is an ELISA Kit and is intended for research purposes only. The pr...
Thermo Scientific™ Sino Biological™ BSG (CD147) Recombinant Mouse Protein, His Tag 5 x 50ug Thermo Scientific™ Sino Biological™ BSG...
Mouse monoclonal antibody raised against recombinant BSG. Recombinant protein corresponding to human BSG. (MAB3633) - Products - Abnova
Basigin je član imunoglobulinske superfamilije sa strukturom koja je srodna mogućem primordijalnoj formi pripadajuće superfamilije. Kao takav ima temeljnu ulogu u unutarćelijskom prepoznavanju koje je uključeni u različite imunološke fenomene, diferencijaciju u razvoj, a za njega se također smatra da ima ulogu i u unutarćelijskom prepoznavanju (Miyauchi et al., 1991; Kanekura et al., 1991).[4][5] Ova supstanca kma različite funkcije. Pored sposobnosti induciranja metaloproteinaze, također regulira i nekoliko distinktnih funkcija, kao što je u spermatogeneza, monocarboksilatni transport i tipa odgovornosti limfocita. Basigin je tip integralnog membranskog receptora koji ima mnoge ligande, uključujući iciklofilin (CyP) proteine Cyp-A i CyP-B i izvjesne integrine.[6][7][8]Ispoljava se u mnogim tipovima a ćelija, uključujući i epitelne, endotelne ćelije i leukocite. Ljudski basigin protein sadrži 269 aminokiselina, koje čine dva jako glikozilirana imunoglobulina tipa C2 domena ...
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The cell-surface glycoprotein basigin - also known as EMMPRIN - enhances growth and invasiveness of human metastatic tumours by stimulating secretion of matrix metalloproteinases (MMPs), which remodel the extracellular matrix. Now, however, Kathryn Curtin and colleagues report that basigin can also have dramatic effects on internal cell architecture (see p. 2649-2660). They show that the Drosophila homologue, D-basigin, promotes integrin-dependent cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. In vivo, loss of D-basigin in photoreceptors leads to misplaced nuclei and other structural changes that suggest disruption of the cytoskeleton; these changes can be rescued by fly or mouse basigin. The authors also report that D-basigin colocalizes with integrins in cultured insect cells and in the fly visual system, and partly colocalizes with actin in cultured insect cells, possibly indirectly through its interaction with integrins. Most importantly, D-basigin interacts ...
Here is the best resource for homework help with BSG 502 : Managerial Economics at Urbana. Find BSG502 study guides, notes, and practice tests from Urbana.
ExiSpin™ has the functions of a vortexer as well as a microcentrifuge and will significantly save your time in the lab. ExiSpin™ comes complete with rotor for 4 x 8-strip tubes and 12 x 1.5/2.0 ml tubes. Use it for Minipreps, to resuspend oligos, set up your PCR reaction, or any task that requires vortexing in micro test tube or 0.2 ml PCR tubes ...
TY - JOUR. T1 - Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma. AU - Hasegawa, Kazuaki. AU - Okui, Tatsuo. AU - Shimo, Tsuyoshi. AU - Ibaragi, Soichiro. AU - Kawai, Hotaka. AU - Ryumon, Shoji. AU - Kishimoto, Koji. AU - Okusya, Yuka. AU - Monsur Hassan, Nur Mohammad. AU - Sasaki, Akira. PY - 2018/10/25. Y1 - 2018/10/25. N2 - Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically, as it can invade facial bones and cause bone pain that is undertreated and poorly understood. Here we studied HNSCC bone pain (HNSCC-BP) in an intratibial mouse xenograft model that uses a human HNSCC cell line (SAS cells). These mice develop HNSCC-BP associated with an upregulation of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in the dorsal root ganglia (DRGs) of sensory nerve cell bodies. Our experiments demonstrated that the inhibition of monocarboxylate transporter 4 (MCT4) by short ...
Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice ...
Paper III. Lauritzen, F., Heuser, K., de Lanerolle, N.C., Lee, T-S.W., Spencer, D.D., Kim, J.H., Eid, T., Bergersen, L.H. (2012) Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. This is the pre-peer reviewed version of the article, which has been published in final form at: Glia 60(7), 1172-1181, July 2012. The published version of this paper is available at: https://doi.org/10.1002/glia.22344 ...
SWISS-MODEL Repository entry for C4ZUK7 (KEFG_ECOBW), Glutathione-regulated potassium-efflux system ancillary protein KefG. Escherichia coli (strain K12 / MC4100 / BW2952)
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Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity ...
Primary liver cancer (hereinafter abbreviated as PLC) is one of the most common types of malignant tumors in clinical practices. Its global prevalence is rising year-on-year and surpasses 626,000 per year. Ranking at No. 5 among all malignant tumors, its mortality rate approaches 600,000 per year and becomes No.3 of tumor-related death. As one of the prevalent regions of PLC in the world, China has a morbidity population of around 55%. Among the tumor-related death, it stands at No. 2 second only to lung cancer. So PLC has been a major hazard to health and life for Chinese citizens. Surgical resection has remained the first therapeutic choice of PLC. However, the disease course of PLC is insidious. In clinical practices, less than 30% of PLC patients may be treated surgically by hepatectomy. And their postoperative occurrences of recurrence and metastasis stay at a high level. As demonstrated by large-sample clinical trials in China, the 5-year postoperative recurrent rate of PLC was as high as ...
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AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
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This image shows the perineurial glia that ensheath the nervous system in Drosophila. Perlecan tagged with GFP (green) marks the extracellular matrix that tightly associates with the perineurial glia (labeled with a red, RFP-tagged membrane marker). The perineurial glia in turn ensheath the entire peripheral nerve including the peripheral axons (labeled in blue) at the core of each nerve. The transmembrane protein Basigin interacts with integrins at focal adhesions to regulate the interaction of integrins with the extracellular matrix, and loss of Basigin leads to compression of the peripheral nerve. For more information, see the article by Hunter et al. (pages 3360-3373). ...
So why did the cylons return after 40 years? Was it to merge the species, sweep away the old pagan rituals, and establish the kingdom of the one God? Was it to simply exterminate humanity. (Ive never thought this was plausible.) Was it to fulfill the prophesies and return to Earth ...
Second night of episode 107 for our Battlestar Galactica campaign. The crew are tracking an archeologist from the University of Leonis that was at the Sagittaron dig thats causing all the social and political strife in our game world after they found out he was a doppleganger of a missing astronomer rom a deep-range outpost that…
CD147 antibody [4D3] (basigin (Ok blood group)) for ICC/IF, IHC-P, WB. Anti-CD147 mAb (GTX84799) is tested in Human samples. 100% Ab-Assurance.
This report studies the global Heavy Aklyl Benzenes (HAB) market status and forecast, categorizes the global Heavy Aklyl Benzenes (HAB) market size (value & volume) by key players, type, application, and region. This report focuses on the top pla
On Wed, Feb 13, 2002 at 05:14:57PM -0800, Thomas Bushnell, BSG wrote: , Debian Policy is correct by requiring everything in /etc to be a , conffile. Debian Policy would be incorrect if it required that. Fortunately, it does not. However, it does forbid configuration files from being included in binary packages unless they are listed as conffiles, which is what I think you are referring to here. , Emacs Policy, by requiring startup files, even ones that are not , configuration files, to be in /etc, thus in effect requires that they , always be conffiles. Is there any way for the admin to disable loading/autoloading of an installed elisp package other than editing these files? If not, then they should be configuration files so that this is possible. -- - mdz ...
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CD147 Antigens: A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
Were told MCTs are shunted straight to the liver via the portal vein. Does the liver have a biological limit to its capacity to handle MCTs? What hap
An efficient solvent for many lipophylic drugs and vitamins, NEOBEE® MCTs emulsify in aqueous environments and help uptake in intestinal cells. They are odorless, tasteless and extremely stable...