PE anti-human CD146 (MUC18, Mel-CAM) Antibody - CD146 is a 118 kD integral transmembrane glycoprotein also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule).

CD146 protein is also known as the melanoma metastasis-associated surface molecule, MUC18, A32 antigen, S-Endo-1 and the melanoma cell adhesion molecule, MCAM or Mel-CAM.

Complete information for MCAM gene (Protein Coding), Melanoma Cell Adhesion Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

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pep:known chromosome:VEGA66:9:44134562:44142727:1 gene:OTTMUSG00000016731 transcript:OTTMUST00000040547 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Mcam description:melanoma cell adhesion molecule ...

CD146/MCAM Antibody 66153-1-Ig has been identified with ELISA, WB, IHC, FC. 66153-1-Ig detected 120 kDa band in A375 cells with 1:500-1:2000 dilution...

Quadrant AG has recently announced that the company will change its name to Mitsubishi Chemical Advanced Materials AG (MCAM) as of April 1,

ausgewählte Publikationen. Ortlepp C, Steudel C, Heiderich C, Koch S, Jacobi A, Ryser M, Brenner S, Bornhäuser M, Brors B, Hofmann W-K, Ehninger G, Thiede C. Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hem. 2013 in press. Thieme S, Gyárfás T, Richter C, Özhan G, Fu J, Alexopoulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandoła J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, Brenner S: The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood 2012, in press.. Stopp S, Bornhäuser M, Ugarte F, Wobus M, Kuhn M, Thieme S, Brenner S. Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells. Haematol 2012, in press.. Rellensmann G, Masjosthusmann K, Brenner S. Therapeutische Hypothermie bei ...

The exaggerated placenta site consists of an exuberant infiltration of the myometrium by implantation site intermediate trophoblasts, representing the extreme end of a physiologic process. The distinction between normal placental site and an EPS is somewhat arbitrary because there is no reliable information quantifying the amount and extent of trophoblastic infiltration at different stages of normal gestation. ...

The excessive metastatic propensity of melanoma makes it the most deadly form of skin cancer, yet the underlying mechanism of metastasis remains elusive. Here, mining of cancer genome datasets discovered a frequent loss of chromosome 19p13.3 and associated down-regulation of the zinc finger transcription factor ZBTB7A in metastatic melanoma. Functional assessment of ZBTB7A-regulated genes identified MCAM, which encodes an adhesion protein key to melanoma metastasis. Using an integrated approach, it is demonstrated that ZBTB7A directly binds to the promoter and transcriptionally represses the expression of MCAM, establishing ZBTB7A as a bona fide transcriptional repressor of MCAM. Consistently, down-regulation of ZBTB7A results in marked upregulation of MCAM and enhanced melanoma cell invasion and metastasis. An inverse correlation of ZBTB7A and MCAM expression in association with melanoma metastasis is further validated with data from analysis of human melanoma specimens. Implications: Together ...

Expression of MCAM (CD146, MUC18) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

Human mesenchymal stromal cells (MSCs) are increasing used in clinical trials for a diverse array of applications. Whether allogenic or autologous cells are used, unqualified efficacy has not been shown, suggesting the innate immune system may be impairing MSC activity. For example, MSCs inherently traffic to osteosarcoma (OS) rendering them potentially effective delivery vehicles of therapeutics; however, such strategies have not emerged, possibly due to inadequate tumor localization. We sought to enhance MSC trafficking to OS studying xenograft models of human osteosarcoma in nude and NOD-scid-IL2rγnull (NSG) mice. After IV infusion, firefly luciferase-expressing MSCs trafficked to the tumor in both models. Interestingly, we observed 3.5-fold greater bioluminescent signal per unit volume from the OS in NSG compared to nude mice, suggesting macrophages in nude mice may be clearing the MSCs. To test our hypothesis, we infused MSCs into tumor-bearing nude mice after clodronate-mediated ...

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

High-density lipoprotein (HDL) amounts inversely correlate with cardiovascular occasions thanks to the protective results on vascular wall structure and control cells, which are susceptible to oxidative modifications and lead to potential pro-atherosclerotic effects then. aspect. Results triggered by ox-HDL could end up being considerably attenuated by pretreatment with brief hairpin RNA-mediated CD36 knockdown or probucol. Data of Rabbit polyclonal to MCAM tests and the inverse correlation of ox-HDL and circulating EPC figures among individuals with coronary artery diseases (CAD) or CAD and type 2 diabetes also supported it. In the mean time, HDL separated from such individuals could significantly increase cultured EPCs caspase 3 activity, further supporting our proposal. This is definitely the most total study to day of how ox-HDL would impair EPCs function, which was involved with service of CD36-p38 MAPK-TSP-1 pathways and proved by not only the inverse relationship between ox-HDL and ...

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Mouse monoclonal antibody raised against native human MCAM. Human umbilical vein endothelial cells (HUVECs). (MAB15401) - Products - Abnova

MesenCult™-ACF Plus, a serum- and animal component-free medium for the derivation and expansion of human mesenchymal stromal cells (MSCs).

Main Article. The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.. ...

Here we present an effective method to investigate the antifibrotic activity of intravenously infused human mesenchymal stromal cells...

Effect of dentin matrix components on the mineralization of human mesenchymal stromal cells.. Petridis X, Beems BP, Tomson P, Scheven B, Giepmans B, Kuipers J, van der Sluis L, Harmsen MC.. Tissue Eng Part A. 2018 Nov 16. doi: 10.1089/ten.TEA.2018.0192. ...

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The molecular changes associated with the transition of melanoma cells from radial growth phase (RGP) to vertical growth phase (VGP) and the metastatic phenotype are not very well defined. However, some of the genes involved in this process and their transcriptional regulation are beginning to be elucidated. For example, the switch from RGP to VGP and the metastatic phenotype is associated with loss of the AP-2α transcription factor. AP-2α regulates the expression of c-KIT, MMP-2, VEGF, and the adhesion molecule MCAM/MUC18. Recently, we reported that AP-2α also regulates two G-protein coupled receptors (GPCRs) PAR-1 and PAFR. In turn, the thrombin receptor, PAR-1, regulates the expression of the gap junction protein Connexin-43 and the tumor suppressor gene Maspin. Activation of PAR-1 also leads to overexpression and secretion of proangiogenic factors such as IL-8, uPA, VEGF, PDGF, as well certain integrins. PAR-1 also cooperates with PAFR to regulate the expression of the MCAM/MUC18 via ...

Oncotarget | https://doi.org/10.18632/oncotarget.2692 Nicola Alessio, Stefania Del Gaudio, Stefania Capasso, Giovanni Di Bernardo, Salvatore Cappabianca, Marilena Cipollaro, Gianfranco Peluso, Umberto Galderisi

The polarity of epithelial cells is critical for proper function. Maintenance of polarity requires sustained proper sorting of proteins and lipids to either apical or basolateral membranes using distinct sorting signals. Compared to basolateral sorting signals, apical signals are not well characterized and can be present within the lumenal, transmembrane, or cytosolic regions of the protein. N-glycosylation has been identified as one of the apical sorting signals. The sialomucin endolyn (CD164) is a transmembrane protein that contains an apical sorting signal (N-glycans) in the lumenal domain and a lysosomal/basolateral targeting signal (YXXØ motif) in its cytoplasmic tail. It cycles between the apical surface and lysosomes of renal epithelial cells and is expressed in embryonic and adult kidney. The first objective of this research was to dissect the specific determinant on N-glycosylation for endolyn apical sorting using a lipofectamine-mediated RNAi approach. The results demonstrated that ...

Using tissue microarrays, we have shown for the first time that high-grade human gliomas are associated with the loss of expression of the AP-2α transcriptional factor, which regulates several genes, such MCAM/MUC18, MMP-2, and c-KIT that have been shown to be important for tumor progression and invasion. Over time, lower-grade astrocytomas can acquire genetic mutations and subsequently evolve to a higher grade (secondary glioblastoma). Differential genetic pathways leading to primary and secondary glioblastoma have been elucidated. The most well-characterized tumor markers associated with progression of glioblastoma are p53, MDM2, EGFR, and PDGF. The frequency of p53 protein accumulation in secondary glioblastoma is ,90%, whereas in primary glioblastoma expression is ,35%. MDM2 forms a complex with p53, thus abolishing its transcriptional activity. Immunohistochemical staining of overexpression of MDM2 is observed in ,50% of primary glioblastomas but in ,10% of secondary glioblastomas. EGFR is ...

MGC-803 cells were cultured in different concentrations of serum containing WEI KANG NING. The inhibitory ratio of the cells was measured by MTT assay. Apoptosis was observed by Hoechst 33258 fluorescence staining ...

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The results of SafeCell study - a systematic review and meta-analysis of safety mesenchymal stromal cell (MSC) therapy, have been published online in PLoS ONE. This is the first and unique analysis of clinical trials, assessing systemic administration of MSC

Clone REA697 recognizes the rat CD146 (LSEC) antigen, also known as Gicerin, MCAM, MUC18, or MEL-CAM. CD146 is a putative cell adhesion molecule of an immunoglobulin (Ig) superfamily which shows homophilic and heterophilic binding activities with two isoforms: S-gicerin, which has small cytoplasmic domain and the same extracellular domain as l-gicerin, shows stronger cell adhesion activity. CD146 is expressed on endothelial cells and a variety of tumor cells and is involved in cell adhesion and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. In rat, neurite promotion activity of CD146 from hippocampal neurons is reported. Additional information: Clone REA697 displays negligible binding to Fc receptors. - Belgique

From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

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Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many ...

Microvascular mural or perivascular cells are needed for the maturation and stabilization of the remodeling vasculature. by treatment of the Alk5-particular inhibitor SB525334 and steady retroviral appearance of the Alk5 major adverse (E232R). Coculture of human being umbilical line of thinking endothelial cell (HUVEC) with 18174-72-6 IC50 hES-MC keeps network sincerity likened to HUVEC only in three-dimensional collagen I-fibronectin by paracrine signaling. Using high-resolution laser beam confocal microscopy, we show that hES-MC make immediate contact with HUVEC also. This demonstrates that hESC-derived mesenchymal cells possess the molecular equipment anticipated in a perivascular progenitor cells 18174-72-6 IC50 and can play a practical part in backing EC systems in three-dimensional tradition. Intro Pathological ischemia from a absence of bloodstream source outcomes in multiple chronic illnesses such as myocardial infarction, heart stroke, diabetic injury curing, and retinopathy. One of the ...

Assalam kak . Thanks sbb bg info mmng sngt mmbntu. Dan yg pling utama kelakar la kak ni . Saya ni msih diawal remaja jd fasa jerawat ni mmng naik la .. cuma sikit n bnyak. Msa sya skolah dulu jerawat naik sikit tp confident tu mmng kurang la . Jd msa saya umur 18 saya ada pegi facial d wangsa maju .. lepas pda facial dalam dua hri mcmtu hbis stu muka saya, naik jerawat .mcam2 jenis jerawat yg naik . Msa tu memang sedih sngt mmng down gila bila kawan ajak keluar memang mlas nk kluar . Malas sbb jerawat bnyak :( Dulu kt dahi lincin skrg penuh mcm dah kembar jerawat tu bercamtum :(( . Sya dh tnya kt semua org tntng ubat yg mereka pkai dan mcm jenis produk sya beli tp still xbrkesan. Dan dlm beberapa hri ni saya trbukak blog akak dan trtarik dgn kisah kak . Saya ikut mcm kak buat pergi jmpa doc.Doc kasi ubat tu memang ok la dia mcm kering tp bru try dua hri haha . Tp xsama ubat yg kak tunjuk tu . Nama pon lain .Doc sarankan sya ulang selama 6 bulan. Sya rsa nk beli cethapil yg kak tnjuk tu tp doc ...

Assalam kak . Thanks sbb bg info mmng sngt mmbntu. Dan yg pling utama kelakar la kak ni . Saya ni msih diawal remaja jd fasa jerawat ni mmng naik la .. cuma sikit n bnyak. Msa sya skolah dulu jerawat naik sikit tp confident tu mmng kurang la . Jd msa saya umur 18 saya ada pegi facial d wangsa maju .. lepas pda facial dalam dua hri mcmtu hbis stu muka saya, naik jerawat .mcam2 jenis jerawat yg naik . Msa tu memang sedih sngt mmng down gila bila kawan ajak keluar memang mlas nk kluar . Malas sbb jerawat bnyak :( Dulu kt dahi lincin skrg penuh mcm dah kembar jerawat tu bercamtum :(( . Sya dh tnya kt semua org tntng ubat yg mereka pkai dan mcm jenis produk sya beli tp still xbrkesan. Dan dlm beberapa hri ni saya trbukak blog akak dan trtarik dgn kisah kak . Saya ikut mcm kak buat pergi jmpa doc.Doc kasi ubat tu memang ok la dia mcm kering tp bru try dua hri haha . Tp xsama ubat yg kak tunjuk tu . Nama pon lain .Doc sarankan sya ulang selama 6 bulan. Sya rsa nk beli cethapil yg kak tnjuk tu tp doc ...

A 28-day ready aerobic biodegradability test in an aerobic aqueous medium with manometric respirometry method was performed on the test item, according to OECD 301F / EC C.4 - D manometric respirometry methods, in accordance with GLP principles. 100 mg/l of test item was inoculated with activated sludge (30 mg/L SS) and incubated under aerobic conditions in a closed respirometer flask at constant temperature (22 ± 2ºC) for 28 days. A blank test, a procedure test with reference substance (sodium acetate) and a toxicity test were run in parallel. In the toxicity test, containing both the test item and a reference item, on the 14th test day the biodegradation (based on ThOD) attained 61.7%. Thus, the test item is not inhibitory. At the 28th day of the test the measured aerobic biodegradation of the test item attained 79.8%. Thus, the test item can be deemed to be readily biodegradable ...

Clinical signs of experimental autoimmune encephalomyelitis (EAE) in rats can be suppressed by treatment with liposomes containing dichloromethylene diphosphonate (Cl2MDP liposomes). Here we investigated whether besides the blood-borne macrophages also ED2+ perivascular cells and microglia are affec …

Hi we have a 13 year old dog with long term hip dysplasia. he has cartrophen once a month and is on daily metcam for analgesia and weekly hydrotherapy sessions....

TY - JOUR. T1 - The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages. AU - Mun, Chin Hee. AU - Kang, Mi Il. AU - Shin, Yong Dae. AU - Kim, Yeseul. AU - Park, Yong Beom. PY - 2018/12/1. Y1 - 2018/12/1. N2 - BACKGROUND:: Mesenchymal stromal cells (MSCs) are multipotent stem cells that can differentiate into several cell types. In addition, many studies have shown that MSCs modulate the immune response. However, little information is currently available regarding the maintenance of immunomodulatory characteristics of MSCs through passages. Therefore, we investigated and compared cytokine and gene expression levels from adipose (AD) and bone marrow (BM)-derived MSCs relevant to immune modulation from early to late passages. METHODS:: MSC immunophenotype, growth characteristics, cytokine expressions, and gene expressions were analyzed. RESULTS:: AD-MSCs and BM-MSCs had similar cell morphologies ...

Supplementary Materials Appendix S1: Supplemental Methods SCT3-8-639-s001. repair, and promote functional recovery ultimately. A moderately serious cervical clip compression/contusion damage was induced at C7\T1 in adult feminine rats, accompanied by an intravenous tail vein infusion one hour post\SCI of (a) term\delivery human umbilical cable perivascular cells (HUCPVCs); (b) initial\trimester human umbilical cord perivascular cells (FTM HUCPVCs); (c) adult bone marrow mesenchymal stem cells; or (d) vehicle control. Weekly behavioral testing was performed. Rats were sacrificed at 24 Prinomastat hours or 10 weeks post\SCI and immunohistochemistry and ultrasound imaging were performed. Both term and FTM HUCPVC\infused rats displayed improved ((LEA, DL\1177, VectorLabs, Canada, 1:300). Myelination and axonal density were quantified using fluro\myelin Prinomastat (type:entrez-nucleotide,attrs:text:F34651″,term_id:4820277″,term_text:F34651″F34651, Molecular Probes; Eugene, OR, ...

TY - JOUR. T1 - Remestemcel-L for the treatment of graft versus host disease. AU - Locatelli, F.. AU - Algeri, M.. AU - Trevisan, V.. AU - Bertaina, A.. PY - 2016/7/29. Y1 - 2016/7/29. N2 - Introduction: Remestemcel-L, a third-party, off-the-shelf preparation of bone-marrow derived mesenchymal stromal cells (MSCs), has been developed for experimental use in acute graft-versus-host disease (aGvHD) and other immune-mediated conditions. Several preclinical and clinical studies have indeed suggested the potential of human mesenchymal stromal cells (MSCs) as an effective treatment for steroid-refractory aGvHD. However, an unambiguous demonstration of efficacy is still lacking. Areas covered: This review critically examines the biologic rationale supporting MSCs use in aGvHD and analyzes the results of published clinical trials in this setting, with a particular focus on the potential benefits and drawbacks of Remestemcel-L. For this purpose, a systematic literature search was performed in PubMed ...

In the present study, we clearly showed that the proliferation and function of HUCPVCs are adversely affected by hyperglycemic condition. Notably, women who had experienced GDM during pregnancy had a low yield of HUCPVCs compared to healthy pregnant women. The major causes of diabetic complications are the persistent production of reactive oxygen species and inflammation caused by exposure to hyperglycemia (Manea et al., 2015). This induces capillaries collapse by accelerating the loss of pericytes, which destroys the homeostasis of cells or tissues. Thus, our result showing lower HUCPVC yield from the GDM patients was somewhat predictable, indicating that we may not be able to obtain sufficient number of PVCs from donors with metabolic abnormalities.. Two independent studies reported the lower proliferation rate of early passage GDM-MSCs isolated from Whartons jelly compared with normal MSCs (Kim et al., 2015; Wajid et al., 2012). It was attributable to premature senescence, which is driven by ...

Sigma-Aldrich offers abstracts and full-text articles by [Xue-Qing Wang, Yong Shao, Chong-Yi Ma, Wei Chen, Lu Sun, Wei Liu, Dong-Yang Zhang, Bi-Cheng Fu, Kai-Yu Liu, Zhi-Bo Jia, Bao-Dong Xie, Shu-Lin Jiang, Ren-Ke Li, Hai Tian].

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