Full Text CA-97-014 PIVOTAL CLINICAL TRIALS FOR CHEMOPREVENTION AGENT DEVELOPMENT NIH GUIDE, Volume 26, Number 7, March 7, 1997 RFA: CA-97-014 P.T. 34 Keywords: Cancer/Carcinogenesis Clinical Trial Chemopreventive Agents National Cancer Institute Letter of Intent Receipt Date: April 3, 1997 Application Receipt Date: May 22, 1997 PURPOSE The Division of Cancer Prevention and Control (DCPC), National Cancer Institute (NCI) invites applications to further the drug development efforts of the Chemoprevention Branch by carrying out intermediate-sized Phase II/III efficacy trials of promising chemopreventive agents in major cancer target organs, particularly prostate, breast, lung, colon, and bladder. Currently, most NCI-sponsored Phase II clinical trials enroll fewer than 100 participants and evaluate a spectrum of potential SEBs as study endpoints over a relatively brief study period (2 weeks 6 months). This is in contrast to the large Phase III clinical chemoprevention trials with tamoxifen, ...

A polymer scale preventive agent for use in the polymerization of a monomer containing an ethylenic double bond is provided. The agent includes (A) a condensation reaction product obtained by reacting an aldehyde compound and a hydroxynaphthalene-based compound in the presence of a reducing agent, and (B) a polymer compound containing a nitrogen atom. This agent is capable of forming a coating with satisfactory scale prevention properties on inner wall surfaces of a polymerization vessel with a single-stage application, enabling the production process time to be shortened and the productivity and quality of polymeric products improved.

Are milk polyamines preventive agents against food allergy? - Volume 59 Issue 1 - Guy Dandrifosse, O. Peulen, N. El Khefif, P. Deloyer, A. C. Dandrifosse, Ch. Grandfils

3,3-Diindolylmethane (DIM) is a naturally occurring indole, which is currently under investigation as a potential chemopreventive agent. The concentrations of DIM in plasma, liver, kidney, lung, heart, and brain tissues were determined following oral administration of two different formulations to mice (250 mg/kg). Mice were sacrificed periodically from 0 to 24 h after administration of either a crystalline or an absorption-enhanced formulation (Bio-Response-DIM; Indolplex) of DIM, and plasma and tissue concentrations were determined by high-performance liquid chromatography (UV detection, 280 nm). A physiologically based pharmacokinetic (PBPK) model was developed to characterize the pharmacokinetic properties of the two different formulations. The final model included parameters reflecting linear first-order absorption, systemic clearance, and distributional clearance in the remainder compartment, which were considered independent of formulation. All pharmacokinetic profiles from the two ...

DIM (3,3-diindolylmethane), a small molecule compound, is a proposed cancer preventive agent that can be safely administered to humans in repeated doses. We report that administration of DIM in a multidose schedule protected rodents against lethal doses of total body irradiation up to 13 Gy, whethe …

Trials are being conducted to determine the authenticity of consuming Indole-3-Carbinol supplements to prevent illnesses, particularly cancer. Although it does not provide an active cure to cancer, Indole-3-Carbinol is scientifically proven to support the health of reproductive organs and cellular reproduction for both men and women. It also assists in detoxifying the intestines and liver.As an antioxidant, it stimulates the production of enzymes that detoxify toxins and protects cell structures including DNA. Lycopene is another vegetable antioxidant with proven health benefits.With possible anti-carcinogenic, antioxidant and anti-atherogenic effects, this vegetable component is only just being acknowledged as a solution to a variety of health issues Indole-3-Carbinol is currently being clinically researched as a cancer preventive agent by the National Institutes of Health.. Other names for Indole-3-Carbinol:. I3C, 3-Indolylcarbinol, 1H-Indole-3-methanol, 3-Hydroxymethyl Indole, 3 Hydroxymethyl ...

A number of possible preventive agents for cancers in different organs have been reported, however, little information is available regarding the effective agents for the development of gastric cancers. The rice components are known to be effective for the prevention of the development of cancers. Our group has demonstrated that fermented brown rice by Aspergillus Orzae (FBRA) has chemopreventive potentials in several organs. In this study, we investigated the modifying effects of FBRA exposed during the initiation or post-initiation phase of N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats. Five-week-old male ACI rats were divided into 7 groups. Groups 1-5 were given oral administration of MNNG (100 mg/l in distilled water) for 24 weeks starting at 6 weeks of age. Groups 2 and 3 were fed a diet containing 5 and 10% FBRA during the initiation phase, respectively, whereas groups 4 and 5 were fed these diets during the post-initiation phase. Group 6 was given a ...

3825 The isothiocyanate sulforaphane (SF) has received increasing interest of late as a promising chemopreventive agent in several model systems. As a natural product derived from cruciferous vegetables, SF has low toxicity, yet is able to regulate many factors important in tumorigenesis, including inflammation, cell cycle and apoptosis. Our current work is focused on determining whether SF is a good candidate for chemoprevention of UV-induced non-melanoma skin cancer (NMSC). Although there have been two published studies using SF in long-term mouse tumorigenesis experiments, the issue of whether SF can protect against NMSC when used concurrently with UVB treatment has not been addressed. We have therefore treated female SKH-1 hairless immunocompetant mice, 20 per group, with either UVB alone, UVB+Acetone, UVB+1μmol SF or UVB+2.5μmol SF. Mice were treated topically three times a week with either vehicle or SF, one hour prior to treatment with UVB. The UVB dosage started at 0.9 kJ/m2 and ...

Despite the intensive efforts and substantial advances that have occurred through focusing on improving treatment, cancer is still a leading cause of death worldwide. Many have argued that this could be avoided by focusing on cancer prevention, which has now entered the arena of targeted therapies. During the process of identifying preventive agents, dietary phytochemicals have emerged as modulators of key cellular pathways. By molecular modeling of the interactions of targeted proteins with these chemopreventive agents, we have provided knowledge for a better understanding of how these preventive agents work. Such knowledge will help the translation to new clinical practice of preventive medicine.. Citation Information: Cancer Prev Res 2011;4(10 Suppl):CN07-02. ...

Introduction: Chronic inflammation is widely recognized as an underlying etiological factor in carcinogenesis; there is enough evidence to support the use of non‐steroidal anti‐inflammatory drugs (NSAIDs), and more importantly, their chemically‐modified NO‐releasing prodrugs (NO‐NSAIDs) as promising chemopreventive agents. Metabolic activation of organic nitrate‐containing NO‐aspirins may lead to a cytotoxic activated linker (a quinone methide), raising safety concerns. Replacement of organic nitrates with N‐diazeniumdiolates as a second‐generation NONO‐NSAIDs allowed us to conduct a head‐to‐head comparison between NCX‐4016 (NO‐aspirin), CVM‐01 (NONO‐aspirin), and aspirin as analgesic, anti‐inflammatory, and anti‐pyretic agents with no significant gastrointestinal toxicity.. Methods: a) Anti‐inflammatory: paw edema induced by intraplantar injection of 100 µL of 1% carrageenan, paw volumes measured up to the tibiotarsal joint immediately prior to ...

Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P , 0.05) and increased lung hyperplastic lesions by 2.4-fold (P , 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.. ...

It has been demonstrated and confirmed that certain nonsteroidal anti-inflammatory drugs which inhibit cyclooxygenase and the synthesis of prostaglandins and other eicosanoids, can reduce the formation of both colon polyps and cancers in experimental animals given known carcinogens. Additionally, the results of several epidemiologic studies have suggested that nonsteroidal anti-inflammatory drugs may reduce the risk of colon polyp occurrence and/or colon cancer mortality. We have carried out a study to evaluate the methodology of the measurement of prostaglandin E2 (PGE2) in human colonic mucosa because its concentration may serve as a valuable intermediate marker of the pharmacological activity in Phase II studies of nonsteroidal anti-inflammatory drugs as colon cancer preventive agents. We studied all aspects of the actual measurement of PGE2 including the extraction efficiency of the PGE2 from the mucosa, the precision of the assay and calculation of the PGE2 content in terms of milligrams of ...

Antiangiogenics have shown to be effective and safe anticancer agents in preclinical animal tumor models but have had mixed results in clinical trials with advanced disease. One possible explanation for the lack of efficacy in these clinical trials could be due to the bulky size of tumors in patients with stage III/IV disease. In theory, antiangiogenics would be predicted to be more effective in preventing smaller avascular tumors from activating the angiogenic switch and thus would be an ideal class of compounds for use in a chemopreventative setting. TM is a potent antiangiogenic compound that has completed numerous phase I/II trials for solid tumors. Results from these clinical trials showed that TM is very well tolerated with minimal adverse effects (6, 11-15). The attractive safety profile of TM suggests that it may be amendable to long-term use and thus be developed as a chemopreventative agent.. Recent work from our laboratory showed that TM significantly retards the development of ...

Sigma-Aldrich offers abstracts and full-text articles by [Srilatha Badaboina, Hyoung-Woo Bai, Yun Hee Na, Chul-Hong Park, Tae Hoon Kim, Tae-Hoon Lee, Byung Yeoup Chung].

The overall hypothesis is that the combination of a low dose of the antiestrogen Raloxifene with omega-3 fatty acids will exert a synergistic breast cancer chemopreventive effect due to the crosstalk of their downstream cellular effects leading to decreased proliferation and increased apoptosis of premalignant mammary cells. Based on the investigators hypothesis that upregulation of functional estrogen receptors in the premalignant lesions is also responsible for the development of hormone independent tumors, the investigators postulate that the combination of antiestrogens and omega-3 fatty acids will reduce the development of both hormone-dependent and -independent tumors. At present, there are no known interventions able to decrease the development of hormone-independent tumors, which are more prevalent, more aggressive, leading to the patients demise. In addition, the investigators postulate that this approach will be safe since it will combine a lower and hence a less toxic dose of ...

Principal Investigator：KAWANISHI Shosuke, Project Period (FY)：2001 - 2003, Research Category：Grant-in-Aid for Scientific Research (B), Section：展開研究, Research Field：Hygiene

The study, conducted by researchers at the Mayo Clinic College of Medicine in Scottsdale, Ariz., suggests this drug one day might be used to prevent and even treat breast tumors. Celebrex, marketed by Pfizer Inc., is a member of the general family of drugs that target the COX-2, an enzyme that plays a major role in arthritis pain and inflammation. This COX-2 inhibitor represents a strong option for treatment of breast cancers, and a preventative agent for treatment of individuals with high risk of developing breast cancer or disease relapse, said Pinku Mukherjee, Ph.D., the senior author of the report ...

Read chapter 6 Conclusions, Recommendations, and Future Directions: Despite increasing knowledge of human nutrition, the dietary contribution to cancer ...

Women have more options than ever for fighting breast cancer. But many arent getting the best screening and care, resulting in missed cancers, over-aggressive...

Please note: Any comments expressed in these opinions do not reflect the opinions of Medical News Today in any way at all. Information posted here is designed to complement, not replace, the relationship between a patient and his/her own physician and should not be regarded as advice given by medical practicioners, or professionals. Please refer to our terms of use and privacy policy for further information. ...

Approximately 1 in 8 women in the U.S. will develop breast cancer in their lifetime. But not every womans chances of developing the disease are the same, and those with more risk factors might benefit from taking chemoprevention agents.. Chemoprevention agents are drugs that can inhibit or slow the growth of cancer cells. For some women who dont currently have breast cancer, taking medications like tamoxifen, raloxifene, or aromatase inhibitors can help reduce their odds for getting some types of the disease in the future, according to new recommendations from the U.S. Preventive Services Task Force (USPSTF).. Heres some more information about these recommendations and how you and your doctor can decide whether these medications are right for you.. ...

Effects of chemopreventive agents on the incidence of recurrent colorectal adenomas: a systematic review with network meta-analysis of randomized controlled trials Sajesh K Veettil,1 Nattawat Teerawattanapong,2 Siew Mooi Ching,3,4 Kean Ghee Lim,5 Surasak Saokaew,6–9 Pochamana Phisalprapa,10 Nathorn Chaiyakunapruk7,8,11,12 1School of Pharmacy/School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia; 2Division of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, Thailand; 3Department of Family Medicine, Faculty of Medicine and Health Sciences, 4Malaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, 5Clinical School, Department of Surgery, International Medical University, Seremban, Negeri Sembilan, 6Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Phayao, 7School of Pharmacy, Monash University Malaysia, Selangor,

Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Cancer chemoprevention, chemical carcinogenesis, cytochrome P450, gluconasturtiin, glucosinolates, isothiocyanates, CRUCIFEROUS VEGETABLE CONSUMPTION, GLUTATHIONE-S-TRANSFERASE, DNA ADDUCT FORMATION, PHASE-II ENZYMES, EPIC-HEIDELBERG COHORT, ACETYL-L-CYSTEINE, A/J MOUSE LUNG, BENZYL ISOTHIOCYANATE, F344 RATS, BRUSSELS-SPROUTS ...

Research in my laboratory focuses on understanding the molecular mechanisms of selenium in cancer chemoprevention and the role of reactive oxygen species in carcinogenesis. Selenium is an essential trance element for human health. Selenium deficiency is known to be linked to the risk of certain cancers. Recent clinical studies demonstrated that selenium is a promising chemopreventive agent for prostate and colon cancers. We are currently studying redox-mediated and epigenetic effects of selenium on cell cycle and apoptosis in human prostate cancer cells. We are interested in determining how selenium modulates intracellular redox state, DNA methylation, and histone protein modifications to regulate the expression of genes involved in protection against oxidative stress, tumor suppression, cell cycle, and apoptosis. We also study combinations of selenium with other dietary chemopreventive agents, DNA methylation inhibitors, and histone deacetylase inhibitors for maximizing cancer prevention and ...

TY - JOUR. T1 - Application of pharmacogenomics to dietary cancer chemoprevention. AU - Prawan, Auemduan. AU - Khor, Tin Oo. AU - Li, Wenge. AU - Kong, Ah Ng Tony. PY - 2007/9. Y1 - 2007/9. N2 - Many lines of evidence demonstrate that certain dietary phytochemicals have cancer chemopreventive effects. These dietary phytochemicals or chemo-preventive agents can suppress or block carcinogenesis by 1 enhancing the biotransformation enzymatic activities for efficient elimination of carcinogens or reactive oxidative or nitrosative species (ROS/RNS); 2 suppressing the growth/inflammatory signaling pathways involved in cancer cell proliferation; and 3 modulating phase II detoxifying/antioxidant enzymes, e.g. glutathione S-transferases (GST), NAD(P)H-quinone reductase 1 (NQO1), UDP-glueuronosyltransferases (UGT), and antioxidant enzymes such as gamma-glutamylcysteine synthetase (γ-GCS) and heme oxygenase 1 (HO1). Comparison of gene expression profiles among Nrf2 wild type and Nrf2 knockout mice showed ...

The studys results suggest that the benefits of tamoxifen to prevent cancer can sufficiently compensate for its side effects in post-menopausal women under age 55 years who have an increased risk of developing breast cancer.. Research has shown that tamoxifen can protect against breast cancer for years after treatment ends, but identifying the group of women who can most benefit from the drug as a cancer preventive agent, without experiencing serious side effects, is a challenge. Side effects of the drug can include pulmonary embolism, endometrial cancer, deep vein thrombosis, and cataracts, as well as hot flashes and early menopause.. To investigate those women who would benefit the most from taking tamoxifen as a cancer preventive drug, Peter Alperin, MD, of Archimedes Inc. in San Francisco, and his colleagues used a mathematical model to simulate a post-menopausal population under age 55 years in a virtual clinical trial comparing tamoxifen treatment with no treatment. The investigators ...

in which A is a hydrocarbon ring optionally be cross-linked with a lower alkylene or an oxygen atom; said lower alkylene and hydrocarbon ring may optionally be substituted by at least one alkyl; and p and q are independently 0, 1 or 2),G is N, CH or COH, and --Ar is an aromatic heterocyclic group, an aromatic hydrocarbon group, benzoyl, phenoxy, or phenylthio, orG is a carbon atom, and --Ar is biphenylmethylidene,where said aromatic heterocyclic group, aromatic hydrocarbon group, benzoyl, phenoxy or phenylthio, and biphenylmethylidene may optionally be substituted by at least one group selected from a lower alkyl, a lower alkoxy and a halogen atom},or an acid addition salt thereof.(2) The therapeutic/preventive agent for cognitive dysfunctions according to the above (1), which is a therapeutic agent for senile dementia.(3) A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the above formula [1], wherein --Ar is an aromatic ...

Colorectal cancer, breast cancer and skin cancer are commonly-reported cancer types in the U.S. Although radiation and chemotherapy are routinely used to treat cancer, they produce side effects in patients. Additionally, resistance to chemotherapeutic drugs has been noticed in cancers. Thus, there i …

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk PA-05-059. NCI

Phenethyl isothiocyanate (PEITC) is a particularly beneficial type of isothiocyanate that shows promise as a treatment for, and preventative of, cancer.

TY - JOUR. T1 - Cancer Chemoprotection by Oltipraz. T2 - Experimental and Clinical Considerations. AU - Helzlsouer, Kathy J.. AU - Kensler, Thomas W.. PY - 1993/9. Y1 - 1993/9. N2 - Oltipraz (4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione) is an antischistosomal drug presently under evaluation as a possible chemoprotective agent in humans. To date, oltipraz has proved effective as an inhibitor of carcinogenesis in experimental models for breast, bladder, liver, forestomach, colon, tracheal, lung, and skin cancer. Studies on the mechanisms of action of oltipraz indicate that it affects the metabolism and disposition of chemical carcinogens, principally through the induction of electrophile detoxication enzymes. While this feature is common to many different classes of both natural and synthetic experimental chemoprotectors (i.e., phenolic antioxidants, isothiocyanates, flavonoids, indoles, cinnamates, coumarins, terpenes, and others), oltipraz may offer the earliest and easiest prospect for ...

N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridine: Anti-HIV Agent; a monomacrocyclic N-pyridinylmethylene cyclam; structure in first source

In recent years, naturally occurring antioxidant compounds present in the diet and beverages consumed by humans have gained considerable attention as cancer chemopreventive agents (1, 2, 3, 4, 5) . Resveratrol, a polyphenolic compound present in grapes, nuts, fruits, and red wine, is a potent antioxidant with anti-inflammatory and cancer-preventive properties (7 , 8 , 10, 11, 12, 13 , 33, 34, 35, 36, 37, 38, 39, 40, 41, 42) . In vitro as well as in vivo studies have suggested that resveratrol may impart chemopreventive effects against certain cancers including skin cancer (10, 11, 12, 13 , 33, 34, 35, 36, 37, 38, 39, 40, 41, 42) . The molecular mechanism(s) by which resveratrol imparts cancer chemopreventive properties is not well defined. The present study was designed to define the mechanism(s) of the antiproliferative effects of resveratrol because it may result in the design of novel approaches for the management of cancer. In this study, we investigated the involvement and mechanism of cell ...

Interest in potential cancer chemopreventive and therapeutic properties of dietary ingredients, which are generally more tolerable in the human body ( 15), has increased in recent years, especially for the cancers that usually do not respond well to currently available therapies ( 17). Therefore, it is not surprising that chemoprevention of colon cancer, the leading cancer-related death in Western countries, is becoming more attractive. One of the dietary ingredients that possess anti-inflammatory and/or antioxidant properties is curcumin. Epidemiologic data suggest that curcumin may be responsible for the lower colon cancer rate in India and Southeast Asia ( 39). Based on that and its long history of consumption without any adverse health effects, curcumin is considered to be a safe chemopreventative agent ( 15).. Although it was suggested previously that curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome pathway ( 40), the exact mechanism was not fully ...

The role of vitamin E in the etiology and prevention of colon cancer is not clear. It is possible that various forms of vitamin E may act differently in colon tissue and may be effective chemopreventive agents. Previous reports of vitamin E and colon cancer have focused on alpha-tocopherol and have not considered other dietary forms of vitamin E. Data from a study of 1,993 cases and 2,410 controls ...

Not every woman should use these preventive agents, but we believe women who are at increased risk for breast cancer should be given the option, because in some cases the magnitude of the risk reduction is large. For some women, these therapies can reduce the risk of breast cancer by up to 50%, said Kala Visvanathan, MBBS, FRACP, MHS, Co-Chair of the Guideline Panel and Associate Professor of Epidemiology and Oncology at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.. Risks and Benefits of Therapy. The guideline provides new insight on the risks and benefits for tamoxifen and raloxifene use in postmenopausal women. The risk and benefit profile for both agents varies by age, race, level of breast cancer risk, and history of hysterectomy. The guideline emphasizes that women should discuss both the risks and benefits of these drugs with their doctors before deciding whether to take these drugs for prevention.. We now have a ...

Perhaps the best way to fight cancer is to prevent it from developing in the first place, and based on newly published research from investigators at the University of Wisconsin-Madison, nanoparticles may be able to make cancer chemoprevention a reality. Using nanoparticles made of a biocompatible polymer, the investigators were able to encapsulate a molecule isolated from green tea that triggers apoptosis and inhibits angiogenesis, two key biochemical events that could prevent cancer. Hasan Mukhtar, Ph.D., led the team that published its results in the journal Cancer Research. One of the chief issues in chemoprevention-the use of biologically active molecules to thwart cancer before it gains a foothold in the body-is that any such agents must be exceedingly safe, since it is likely that a person at risk for cancer would need to take the chemopreventive agent on a regular basis for a long time. Because of this requirement, many investigators have been screening naturally occuring molecules for ...

VELASCO-BEJARANO, Benjamín et al. Diindolylmethane Derivatives as Apoptosis Inductors in L5178y Cells. J. Mex. Chem. Soc [online]. 2008, vol.52, n.3, pp.224-228. ISSN 1870-249X.. Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitu-moral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.. Palabras clave : DIM derivatives; apoptosis; cytotoxic effects; L5178Y cells. ...

B144 Hepatocellular carcinoma (HCC) is a common complication of hepatitis C cirrhosis. Because of immigration from countries with a high prevalence of hepatitis B, as well as the increasing age of Americans who contracted hepatitis C during the 1960s through 1980s, the incidence of HCC is increasing in the United States, and is projected to double between 2000 and 2010. At present, there is no effective chemopreventive agent for HCC. Epidemiologic studies have reported an increased risk for HCC among males and in patients with cirrhosis, older age and elevated serum level of alpha-fetoprotein (AFP). SAMe has been used as a drug in Italy and other European countries for more than 20 years. It has an excellent safety profile. In the body, SAMe is a component of the methionine cycle and is found in all cells. Inactivation of methionine adenosyl transferase in cirrhosis reduces the conversion of methionine into SAMe. The resulting reduction in SAMe level may contribute to decreased synthesis of ...

Turmeric is the most studied herb with coumarins. A study evaluated the chemopreventative effects of curcumin, the most active coumarin, on radiation- induced tumors in rat mammary glands. One control group was fed a basic diet while the other control group was fed a diet containing 1% curcumin. The control group fed curcumin had 28% reduction in tumors while 84% of the other group developed mammary tumors. Other studies also show that curcumin inhibits chemically-induced carcinogenesis of the skin, colon, and stomach. ...

Chronic inflammation and nuclear factor-kappa B (NFkappaB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFkappaB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFkappaB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea. NFkappaB activation and inflammatory cytokines were measured post implantation. The combination of soy and tea suppressed NFkappaB p50 binding activity and protein levels via induction of IkappaBalpha. Soy and tea also decreased prostate inflammatory infiltration, increased Bax/BcL2 ratio and ...

Despite recent advances in medicinal chemistry, intrinsic and acquired resistance to chemotherapy treatments and the possibility of relapse present drawbacks in the treatment of breast cancer [39]. Because of the clear risks posed by chemotherapy, researchers worldwide have started searching for natural products that have better anti-carcinogenic activity without side effects. In addition, we believe that long chemotherapy treatment weakens the immunological defense system of the body and leaves patients susceptible to other infections and diseases. Radiation therapy is another treatment to combat cancer but also shows several potentially harmful side effects including weakened immune system and the potential to induce carcinogenesis itself. Therefore, there is an urgent need to develop chemoprevention approaches for the prevention of cancer. Chemoprevention is an important function area of oncology that focuses on the prevention of cancer using natural or synthetic agents. Recently, natural ...

Taking oxygen as a vitamin O supplement is a practice not endorsed by any major medical organization. There appears to be two types of vitamin O products available on the market. The first is an expensive health supplement that is composed largely of salt water and stabilized or aerobic oxygen, and is marketed under many different brand names. Companies, such as RGarden have advertised vitamin O (without germanium) as a purported cure or preventive agent for serious diseases such as cancer, heart disease, and lung disease. It has also been claimed that when taken by mouth, vitamin O supplements may enrich the bloodstream with supplemental oxygen. The second vitamin O product currently available contains the element germanium, which when synthetically derived has been said to be potentially nontoxic and safe at high doses. The various health claims for use of vitamin O have not been substantiated with scientific evidence. However, numerous product testimonials mention the effects of vitamin ...

Not kidding. A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications Nicotine may be suggested as a potential preventive agent...

such a new brilliant approach to eradicate cancer! this is interesting and beneficial as the bacterial proteins termed azurin & ATP-01 not only found effective in anticancer but also cancer preventive activity. Besides, because those bacteria are naturally-occurring human bacterial symbionts, i think it is higher chances to reduce/prevent immunogenicity and always non-toxic to human. its great to hear that ATP-01 also effective in anti-HIV/AIDS activity, should be a great invention and discovery! ...

1) Great natural anti-inflammatory. Acay berries contain powerful antioxidants known as tannins, which are famous for their impressive anti-inflammatory activity. Research has revealed high inflammation levels often accompany chronic conditions such as diabetes, cardiovascular disease and cancer. Treating inflammation is a first step towards the prevention of chronic illness.. 2) Anti-carcinogenic activity. Carcinogens are natural or synthetic (man-made) substances that damage normal, healthy cells and cause them to turn into cancer cells. Ellagic acid, a potent compound found in the acay berry, prevents certain carcinogens such as nitrosamines from food from binding to our DNA and causing cancerous formations. Regular consumption of the berries thus constitutes an important factor in the prevention of certain forms of cancer.. 3) Promotes cardiovascular health. Acay berries contain Omega-9 and Omega-6 fatty acids in the form of oleic acid and linoleic acid. These healthy monounsaturated and ...

1) Great natural anti-inflammatory. Acay berries contain powerful antioxidants known as tannins, which are famous for their impressive anti-inflammatory activity. Research has revealed high inflammation levels often accompany chronic conditions such as diabetes, cardiovascular disease and cancer. Treating inflammation is a first step towards the prevention of chronic illness.. 2) Anti-carcinogenic activity. Carcinogens are natural or synthetic (man-made) substances that damage normal, healthy cells and cause them to turn into cancer cells. Ellagic acid, a potent compound found in the acay berry, prevents certain carcinogens such as nitrosamines from food from binding to our DNA and causing cancerous formations. Regular consumption of the berries thus constitutes an important factor in the prevention of certain forms of cancer.. 3) Promotes cardiovascular health. Acay berries contain Omega-9 and Omega-6 fatty acids in the form of oleic acid and linoleic acid. These healthy monounsaturated and ...

11. Garlic, For centuries garlic has been used as natural medicine to prevent or treat a wide range of diseases and conditions. Multiple studies published throughout the last 10 years confirm that using small amounts of herbs and spices in recipes can yield big health benefits. A review of garlics impact on heart health found that this flavorful herb may help to improve cholesterol and triglyceride levels and aid in blood clotting. Other studies have showed that consuming garlic may help protect against stomach and colorectal cancers. You can reap garlics health benefits by chopping it finely to release allinase, an enzyme that aids in the formation of garlics cancer-protective compounds. Since cooking stops the activity of this beneficial enzyme, its best to let crushed garlic stand for 10 minutes after chopping, before adding it to heat - this prevents total loss of its anti-carcinogenic activity ...

Arathi, Bangalore Prabhashankar. and Raghavendra-Rao Sowmya, Poorigali and Kuriakose, Gini Chempakathinal. and Shilpa, Shivaprasad. and Shwetha, Hulikere Jagdish. and Sharath Kumar, . and Marisiddaiah Raju, . and Baskaran, Vallikannan. and Lakshminarayana, Rangaswamy. (2018) Fractionation and Characterization of Lycopene-Oxidation Products by LC-MS/MS (ESI)+: Elucidation of the Chemopreventative Potency of Oxidized Lycopene in Breast-Cancer Cell Lines. Journal of Agricultural and Food Chemistry, 66 (43). pp. 11362-11371. ISSN 0021-8561 Arathi, Bangalore Prabhashankar. and Sowmyaa, Poorigali Raghavendra-Rao. and Kuriakose, Gini Chempakathinal. and Vijaya, Kariyappa. and Baskaran, Vallikannan. and Jayabaskaran, Chelliah. and Lakshminarayana, Rangaswamy. (2016) Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines. Food and Chemical Toxicology, 97. pp. 265-276. ISSN 0278-6915 ...

The article discusses research indicating that stilbenes, the phytochemicals in grapes and berries, may help prevent cancer of the colon.. ...

Primary screening for HPV provides 60% - 70% greater protection against invasive cervical cancer than the cytology-based screening currently used.

New research published in JAMA Internal Medicine suggests that anticoagulant warfarin may reduce the incidence of cancer in older adults.

Most medical authorities recommend a colonoscopy as the preferred and most accurate screening tool for identification of colorectal cancer in its early stages.

Reducing the size, weight, and density of stools to the norm, is the most important and effective step toward the goal of preventing colorectal cancer.

Cell motility involves metastasis suppressors and other regulators that play an important role in tumor invasion and metastasis. Phenethyl isothiocyanate (PEITC), found in dietary cruciferous vegetables, has been found to exhibit antitumor properties and therefore is of special interest for the development of chemopreventive and chemotherapeutic agent for human cancers. Here, we report that in addition to its function as an anticancer agent, and PEITC can inhibit migration and invasion through the extracellular signal-regulated kinases 1/2 (ERK1/2), protein kinase C (PKC) and nuclear factor-kappaB (NF-kappaB) signaling pathways in human gastric cells. The results from wound healing and Boyden chamber assays (migration and invasion) assay indicated that PEITC exhibited an inhibitory effect on the migration and invasion of AGS cells. Results from Western blotting examination demonstrated that PEITC exerted an inhibitory effect on the ERK1/2, mitogen-activated protein kinase kinase 7 (MKK7), MAP ...

Diindolylmethane is suggested to balance levels of estrogen, creating a healthy hormone balance for both men and women. Effects can relieve...

The new nanoparticle, which delivers the drug in a form activated when it reaches its target, also treats tumors more effectively than the unadorned drug in mice.

A group of scientists at UCLA have cooked up some compounds that could harness the cancer-fighting properties of metformin while avoiding the biological hurdles that have limited its effect in past studies. And Enlibrium, a weeks-old startup, has licensed those assets and raised a $15 million in Series A cash to test out the idea.

Introduction and objective: The anticarcinogenic potential of milk fat can be attributed to its antioxidant, anti-inflammatory, immunostimulatory properties as well as the presence of compounds with antimutagenic effects. In view of the high incidence of cancer the aim of this article was to...

Buy DIM Diindolymethane Capsules. DIM Diindolymethane aids healthy estrogen metabolism and helps balance hormones for men and women. We offer it for only...

Cancer is one of the fatal diseases, and it continues to pose a significant health problem worldwide. Although great efforts are being done to discove..

Pure Encapsulations Indole-3-Carbinol 200 mg is a cruciferous phytonutrient that promotes prostate, breast and cervix health. Made in USA.

CARBINÓL, carbinoli, s.m. Denumire veche a alcoolului metilic. - Din fr. carbinol. Trimis de valeriu, 11.02.2003. Sursa: DEX 98  CARBINÓL s. v. alcool metilic, metanol. Trimis de siveco, 05.08.2004. Sursa: Sinonime  carbinól s. m., pl.…

this group is for every human being who wants to avoid or who has cancer and whats to do something about it - 801010 LFRV is a cancer preventive.