Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated to these drugs. Too few patients used paracetamol for any conclusion to be drawn on its role.. ...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
Objective. To determine whether race is a predictor of a patients likelihood of being prescribed selective cyclooxygenase-2 inhibitors (COX-2s) versus other nonsteroidal anti-inflammatory agents (NSAIDs) in Medicaid managed care plans (MCO).. Design. All medical and prescription claims for Medicaid MCO enrollees receiving at least one prescription for a COX-2 or NSAID between January 2000 and June 2002 were retrieved. Selected for study were adults claiming at least one COX-2 prescription or NSAID prescription with a minimum 30 days of supply after June 2000; having 60 total days of supply or more over the study period was also required for study inclusion. The probability of being prescribed a COX-2 was estimated as a logistic function of patient age, gender, race, city/suburban/rural residence, and history of rheumatoid arthritis, osteoarthritis, chronic back pain, acute pains, gastrointestinal problems, use of anticoagulants or corticosteroids, and comorbidities.. Results. Of the 16,868 ...
The relative risk for use of the cyclo-oxygenase-2 inhibitors celecoxib, rofecoxib, and for other non-steroidal anti-inflammatory drugs was assessed.. The doctors identified a total of 3083 cases of acute pancreatitis and 30,830 population controls.. For current use, the relative risk estimate for celecoxib was 1.4, and 1.3 for rofecoxib.. The overall relative risk for other non-steroidal anti-inflammatory drugs was 2.7.. However, the team noted substantial variation in risk between the individual drugs.. The highest relative risk was for diclofenac, and the lowest for naproxen.. Dr Sorensens team concluded, Cyclo-oxygenase-2 selective inhibitors are associated with a lower risk of acute pancreatitis than most other non-steroidal anti-inflammatory drugs. ...
Selective cyclo-oxygenase 2 (COX 2) inhibitors, including celecoxib (Celebrex) and rofecoxib (Vioxx), are hypothesised to have a lower risk of gastrointestinal complications than traditional non-steroidal anti-inflammatory drugs.1 In September 2000 the celecoxib long term arthritis safety study, better known as CLASS, was published in JAMA.2 This trial, widely cited and distributed, concluded that a COX 2 inhibitor was associated with a lower incidence of complications than traditional non-steroidal anti-inflammatory drugs. What was much less widely publicised were criticisms that contradicted this conclusion.. CLASS was reported as a three arm trial comparing celecoxib 800 mg/day with ibuprofen 2400 mg/day and diclofenac 150 mg/day in osteoarthritis or rheumatoid arthritis. Clinically relevant upper gastrointestinal ulcer complications (bleeding, perforation, or obstruction) and symptomatic ulcers during the first six months of treatment were described as the two main outcome measures, ...
It has been proposed that aspirin (ASA) and other non-steroidal anti-inflammatory drug (NSAID)-induced urticaria (UR)/angioedema (AE) are mediated through inhibition of cyclooxygenase-1 (COX-1) enzymes. Therefore, drugs with COX-2 selectivity may be well tolerated in such patients. We investigated the safety of preferential COX-2 inhibitor meloxicam in subjects with UR or AE type intolerance reaction to classical ASA/NSAIDs. Subjects with reliable or documented history of UR/AE due to classical ASA/NSAIDs underwent a single-blinded, placebo-controlled oral challenge with a cumulative dose of 7.5 mg meloxicam on 2 separate days. One-quarter and three-quarter divided doses of placebo and the active drug were given at 1-h intervals. A total of 116 patients (86 women and 30 men, mean age 39.6 ± 12.7 years) were enrolled to the study. The rate of atopy was 25.9%. Mean duration of drug reaction was 87.4 ± 110.8 (1-720) months. Almost half of the patients were multi-reactors. The most comorbid ...
TY - JOUR. T1 - Prediagnostic nonsteroidal anti-inflammatory drug use and lung cancer survival in the VITAL study. AU - Brasky, Theodore M.. AU - Baik, Christina S.. AU - Slatore, Christopher G.. AU - Alvarado, Mariela. AU - White, Emily. PY - 2012/10. Y1 - 2012/10. N2 - Introduction: Inflammation is important for lung oncogenesis. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to improve colorectal cancer survival. However, few studies have examined the association in lung cancer patients. Methods: The VITamins And Lifestyle (VITAL) cohort includes Washington State residents, aged 50 to 76 years, who completed a baseline questionnaire between 2000 and 2002. Participants responded on the frequency and duration of use of individual NSAIDs in the previous 10 years. Subjects of this study were 785 members of the cohort, who were identified with incident lung cancer from baseline through 2007 through linkage to a population-based cancer registry. Participants were followed for ...
Synthesis, characterization, and biological activities of a Cu(II) complex with the non-steroidal antiinflammatory drug flufenamic acid
In our aim to provide our erudite clients with the best research material with absolute in-depth information of the market, our new report on Global Non-steroidal Anti-inflammatory Drugs Market is confident in meeting their needs and expectations. The 2017 market research report on Global Non-steroidal Anti-inflammatory Drugs Market is an in-depth study and analysis of the market by our industry experts with unparalleled domain knowledge.. The report will shed light on many critical points and trends of the industry which are useful for our esteemed clients. The report covers a vast expanse of information including an overview, comprehensive analysis, definitions and classifications, applications, and expert opinions, among others. With the extent of information filled in the report, the presentation and style of the Global Non-steroidal Anti-inflammatory Drugs (NSAID) Market report is a noteworthy.. The Global Non-steroidal Anti-inflammatory Drugs (NSAID) Industry report provides key ...
Pregabalin Confers No Added Benefit to a Non-steroid Anti-inflammatory Drug and Acetaminophen Regimen in Outpatient Breast Cancer Surgery: A Randomized Controlled Trial Abstract.
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Purpose Non-selective (NSAIDs) and selective (COX-2) nonsteroidal anti-inflammatory drugs are commonly used for their analgesic and anti-inflammatory effects. Their role after orthopaedic surgery has...
TY - JOUR. T1 - Effect of nonsteroidal antiinflammatory drugs on fracture healing. T2 - a laboratory study in rats.. AU - Altman, R. D.. AU - Latta, L. L.. AU - Keer, R.. AU - Renfree, K.. AU - Hornicek, F. J.. AU - Banovac, K.. PY - 1995. Y1 - 1995. N2 - We studied the effects of two nonsteroidal antiinflammatory drugs (NSAIDs) on fracture healing in rats: ibuprofen (30 mg/kg/day) and indomethacin (1 mg/kg/day). Femoral fractures were induced via a three-point bending technique. NSAIDs were administered orally for 4 or 12 weeks. Control animals received no medication. In each group a minimum of six animals were killed at the following intervals: 2, 4, 6, 8, 10, and 12 weeks postfracture. Fracture healing was determined by mechanical testing and histologic evaluation. The bending strength of each fractured femur was expressed as a percentage of the strength of the intact, contralateral femur. Histologic evaluation was performed on serial longitudinal sections stained with hematoxylin and eosin ...
Interaction with platelet function by non-steroidal anti-inflammatory drugs (NSAIDs) is related to the inhibition of cyclo-oxygenase-1 (COX-1). In pat
Abstract: : Purpose: The degeneration of retinal neurons results in loss of vision. It has been known that Non Steroidal Anti-Inflammatory Drugs (NSAIDs) can protect the neuron from ischemic damage. The purpose of this study was to investigate the protective effect of NSAIDs in the rat retinal ischemia. Methods: Retinal ischemia in Sprague Dawley rats was induced by high intraocular pressure at 160 mmHg for 60 minutes after intra-ocular injection of saline, aspirin (5 to 20 mM), sulfasalazine (1 to 5 mM) or sulindac (0.01 to 0.1 mM). For morphological study, the retinas were embedded in epon 24 hours after ischemic injury. To determine neuronal survivorship in the retinal layers, the number of viable neurons was counted in 100µm X 25µm square and examined. Results: The intravitreal injections of aspirin, sulfasalazine or sulindac attenuated the ischemic neuronal degeneration in dose dependent. The protective effect of aspirin at concentration of 20 mM was observed to be 73%5.4 and 80%2.5 in ...
NOTE: The calculations below are standard scaling factors that would be used for the FDA. They do not take into account specific pharmacokinetics of individual agents which can only properly be done after gavage dosing.. HEDs were calculated as follows, using 100 ppm (100 μg/g diet) as an example. Rats, which eat 15 g food daily, would consume 1.5 mg drug; for a 250 g rat, the daily weight-based dose would be 6 mg drug/kg body weight. Dividing by the rat-to-human scaling factor of 6, the HED is 1 mg/kg body weight; for an 80 kg human this is 80 mg. Mice, which eat 4 g food daily, would consume 0.4 mg drug; for a 25 g mouse, the daily weight-based dose would be 16 mg drug/kg body weight. Dividing by the mouse-to-human scaling factor of 12, the HED is 1.33 mg/kg body weight; for an 80 kg human this is 106 mg.. Abbreviation: HED, human equivalent dose.. ...
Cyclooxygenase (COX)-2 participates essentially in bone healing, demonstrated by COX-2 knockout mice that showed delayed fracture repair. Considerable controversy still exists on inhibitory effects of COX-2 inhibitors on bone healing in clinical case
Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study ...
Title:Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review. VOLUME: 15 ISSUE: 8. Author(s):Lalit Kumar, Shivani Verma, Mehakjot Singh, Tammana Chalotra and Puneet Utreja*. Affiliation:Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, I. K. Gujral Punjab Technical University, Jalandhar-Punjab 144601, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021. Keywords:Dendrimer, liposomes, nanocarrier, nanofibers, transdermal, niosomes, ethosomes.. Abstract:Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like ...
Title: Non-Steroidal Anti-Inflammatory Drugs as Anti-Amyloidogenic Compounds. VOLUME: 14 ISSUE: 30. Author(s):Mie Hirohata, Kenjiro Ono and Masahito Yamada. Affiliation:Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan.. Keywords:Alzheimers disease, amyloid β-peptide (Aβ), amyloidosis, α-synuclein fibrils, central nervous system, neuroinflammation, non-steroidal anti-inflammatory drugs (NSAIDs), protein-misfolding disorders. Abstract: Amyloidosis is a clinical disorder caused by deposition of proteins that abnormally self-assemble into insoluble fibrils and impair organ function. More than 20 unrelated precursor proteins lose their native structure and misfold, leading to the formation of amyloid fibrils. The latter share cross-β core structure in vivo and in vitro and gain abnormal functions. Local amyloid deposition occurs in the central nervous system in Alzheimers disease (AD) and cerebral amyloid ...
The efficacy of using a nonsteroidal anti-inflammatory agent such as ibuprofen for the salvage of ischemic and reperfused myocardium was investigated by examining its ability to improve global and...
Buy Cheap on line Anti Viral - Melora (Brand name: mobic) - Mobic is a non steroidal anti-inflammatory drug that is used in the treatment of arthritis.
In 1995 − 1996, participants in the California Teachers Study completed a baseline questionnaire on family history of cancer and other conditions, use of NSAIDs, menstrual and reproductive history, self-reported weight and height, living environment, diet, alcohol use, and physical activity. In 2005-2006, 57,164 participants provided some updated information, including use of NSAIDs and 1457 of these participants developed invasive breast cancer before January 2013. Multivariable Cox proportional hazards regression models provided hazard rate ratios (HRR) for the association between NSAID use and risk of invasive breast cancer as well as hormone receptor- and HER2-defined subtypes.. ...
Treatment and chemoprevention of NSAID-associated gastrointestinal complications Edward J Frech1,2, Mae F Go1,21GI Section, George E Wahlen Department of Veterans Affairs Medical Center; 2Division of Gastroenterology, University of Utah School of Medicine, Salt Lake City, Utah, USAAbstract: The use of non-steroidal anti-inflammatory drugs has become ubiquitous worldwide and remains a common source of gastrointestinal morbidity. Antisecretory medications, particularly proton pump inhibitors, are effective in the treatment and prevention of NSAID-related gastrointestinal complications, including peptic ulcer disease and non-ulcer dyspepsia. A careful assessment of patients risk factors for developing NSAID-related gastrointestinal complications should be undertaken prior to initiation of any NSAIDs. Patients who are considered at risk for developing gastrointestinal complications should receive concurrent antisecretory medical therapy to minimize the risk for GI complications.Keywords: NSAIDs, peptic
The U.S. Food and Drug Administration (FDA) is strengthening an existing label warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke. Based on our comprehensive review of new safety information, we are requiring updates to the drug labels of all prescription NSAIDs. As is the case with current prescription NSAID labels, the Drug Facts labels of over-the-counter (OTC) non-aspirin NSAIDs already contain information on heart attack and stroke risk. We will also request updates to the OTC non-aspirin NSAID Drug Facts labels ...
... s, usually abbreviated to NSAIDs-but also referred to as nonsteroidal anti-inflammatory agents/analgesics (NSAIAs)
... s, usually abbreviated to NSAIDs-but also referred to as nonsteroidal anti-inflammatory agents/analgesics (NSAIAs)
NSAIDs (non steroidal anti-inflammatory drugs) like ibuprofen (Advil) and indomethacin may speed up the breakdown of cartilage in osteoarthritic joints. They might also inhibit tissue repair. But, not all studies show NSAIDs damage cartilage. It may depend on the specific NSAID. The best study Ive seen to date (and also published in a very reputable journal) found older adults (a group that commonly has osteoarthritis) who used NSAIDs including diclofenac, ibuprofen, naproxen, ketoprofen and piroxican for an extended period of time had higher risk of cartilage defects and nonsignificant loss of cartilage compared to nonusers.. Osteoarthritis is very common (athletes, older adults, those who are overweight, those who have been very active their whole life) and is "wear and tear" arthritis; symptoms include joint pain and stiffness.. If you have mild osteoarthritis look for other solutions including curcumin, glucosamine and chondroitin sulfate, and boswella serrata AKBA.. ...
NSAIDs (non steroidal anti-inflammatory drugs) like ibuprofen (Advil) and indomethacin may speed up the breakdown of cartilage in osteoarthritic joints. They might also inhibit tissue repair. But, not all studies show NSAIDs damage cartilage. It may depend on the specific NSAID. The best study Ive seen to date (and also published in a very reputable journal) found older adults (a group that commonly has osteoarthritis) who used NSAIDs including diclofenac, ibuprofen, naproxen, ketoprofen and piroxican for an extended period of time had higher risk of cartilage defects and nonsignificant loss of cartilage compared to nonusers.. Osteoarthritis is very common (athletes, older adults, those who are overweight, those who have been very active their whole life) and is "wear and tear" arthritis; symptoms include joint pain and stiffness.. If you have mild osteoarthritis look for other solutions including curcumin, glucosamine and chondroitin sulfate, and boswella serrata AKBA.. ...
Youll see a lot of attention focused on how to reduce GI bleeding and ulcers in patients taking NSAIDs. ... Learn more with Prescribers Letter.
In ancient times, it was believed throughout the world that the root cause of ailments was the bodys buildup of toxins. This accumulation of toxins and incomplete processes of food in the gastrointestinal tract can be thought to be a source of decreased immunity. This concept of toxicity, food allergens and environmental toxic sources lead to a creation of immune complications, which in turn creates the many symptoms in patients suffering from arthritis. Natural therapy, including taking supplements and herbs, and taking care of your intestinal tract, can increase your chances of becoming symptom free. Its important to understand that taking non-steroidal anti-inflammatory agents(NSAIDS) make the lining of your intestinal tract weaker, thus, giving you "leaky gut" which leads to worsening of disease. The intestinal tracts position and processes are integral in keeping your body healthy because it is the bodys first line of defense. Keeping awareness of what can induce GI inflammation will be ...
In ancient times, it was believed throughout the world that the root cause of ailments was the bodys buildup of toxins. This accumulation of toxins and incomplete processes of food in the gastrointestinal tract can be thought to be a source of decreased immunity. This concept of toxicity, food allergens and environmental toxic sources lead to a creation of immune complications, which in turn creates the many symptoms in patients suffering from arthritis. Natural therapy, including taking supplements and herbs, and taking care of your intestinal tract, can increase your chances of becoming symptom free. Its important to understand that taking non-steroidal anti-inflammatory agents(NSAIDS) make the lining of your intestinal tract weaker, thus, giving you "leaky gut" which leads to worsening of disease. The intestinal tracts position and processes are integral in keeping your body healthy because it is the bodys first line of defense. Keeping awareness of what can induce GI inflammation will be ...
OBJECTIVE: To evaluate the prophylactic effect of ranitidine 150 mg twice daily in patients requiring one of the following non-steroidal anti-inflammatory drugs: naproxen, piroxicam, diclofenac, and indomethacin. In addition, risk factors were studied in order to help in targeting of such treatment to specific groups of patients. DESIGN: Double blind, placebo controlled, randomised, parallel group with endoscopic assessments at 0, 4, and 8 weeks. SETTING: Multicentre outpatient study at secondary referral centres in five European countries. PATIENTS--297 patients with rheumatoid arthritis or osteoarthritis over the age of 18 without lesions in the stomach and duodenum at baseline endoscopy (after one week without taking non-steroidal anti-inflammatory drugs). Those taking other antirheumatic agents, concomitant ulcerogenic drugs, or treatment for peptic ulcers within the previous 30 days were excluded. Age, sex, arthritic disease, and type of non-steroidal anti-inflammatory drug used were ...
4.1 Therapeutic indications. In the treatment of duodenal ulcer and benign gastric ulcer including that associated with non-steroidal anti-inflammatory agents. Prevention of non-steroidal anti-inflammatory drug (including aspirin) associated duodenal ulcers, especially in patients with a history of peptic ulcer disease. Zantac Tablets are also indicated for treatment of post-operative ulcer, reflux oesophagitis, Zollinger-Ellison syndrome and other conditions where reduction of gastric acid secretion is likely to be beneficial.. Children (3 to 18 years). · Short term treatment of peptic ulcer · Treatment of gastro-oesophageal reflux, including reflux oesophagitis and symptomatic relief of gastro-oesophageal reflux disease. 4.2 Posology and Method of Administration. Adults (including the elderly) / Adolescents (12 years and over) The usual initial dosage is 150mg bd or 300mg nocte. This may be increased to ranitidine 300mg twice daily without an increased incidence of unwanted effects. ...
Drugs a) NSAIDs. The cornerstone of DJD treatment is Non Steroidal Anti-Inflammatory Drugs (NSAIDS). They have both anti-inflammatory and analgesic (pain killing) effects. All NSAIDs have the potential to cause side effects in some animals. These include: - Gastro-intestinal side effects such as vomiting and diarrhoea can occur. More seriously ulceration of the gastro-intestinal tract can occur. This causes vomit with blood in it, black tar like faeces (malaena), and can be fatal if left untreated. - Exacerbation of degradation of the articular cartilage by increasing cartilage breakdown or by reducing glycosaminoglycan synthesis. Thus, the drug that is most commonly used for treating DJD has been shown to speed up the progress and deterioration of the disease. - Kidney toxicity. Nsaids can be damaging to kidneys especially where there is existing kidney disease or when there is risk of low blood pressure such as dehydration, heart disease, general anaesthetic - Affect blood clotting - Liver ...
Although the disease cannot be cured, anti-inflammatory drugs, through pain reduction, often allow improvement in sleep and general well-being, resulting in a greater ability to carry out exercises. Analgesics themselves have a very little role, if any, in this condition. The symptoms-related inflammation and therefore non-steroidal anti-inflammatory drugs are appropriate. However, for those individuals who cannot tolerate non-steroidal anti-inflammatory drugs, usually with gastrointestinal complications, a pure analgesic may be the only alternative. This is why it is important to take this medication when the stomach contains food, to protect the stomach lining from any damage. However, these drugs are not habit-forming. There are over twenty different non-steroidal anti-inflammatory drugs, which come in many different shapes and sizes. The best one is a slow release agent which can be taken on a single occasion per day, usually at night, allowing improved sleep, less morning stiffness and less ...
Several reports indicate that mesalazine (5-aminosalicylic acid or 5-ASA) is a promising candidate for the chemoprevention of Colo-Rectal Cancer (CRC) due to its ability to reach the purpose, yet avoiding at the same time the side effects that are usually determined by prolonged administrations of Non Steroidal Anti-Inflammatory Drugs. This activity of 5-ASA is probably the consequence of a number of effects determined on colon cancer cells and consisting of reduced proliferation, increased apoptosis and activation of cell cycle checkpoints. A recent observation has suggested that these effects could be mediated by the capacity of 5-ASA to interfere with the nuclear translocation of beta-catenin, in turn responsible for the inhibition of its transcription activity. The aim of our study was to better characterize the molecular mechanism by which 5-ASA inhibits the beta-catenin signaling pathway. To address this issue we assessed, by means of the Affymetrix microarray methodology, the transcriptome
Clinical experience likewise suggests that some dogs and cats may appreciably benefit from chondroitin administration and others not at all. It is difficult to anticipate which animals are most likely to respond. Given the potential for benefit and the extremely low risk of any adverse side effects, chondroitin supplementation is always recommended for animals with joint pain. Where a benefit is seen, doses of more expensive and potentially deleterious drugs may be reduced, including the NSAIDs (non steroidal anti-inflammatory drugs) such as aspirin, carprofen and meloxicam. Because chondroitin protects mucosal barriers, it may not only enhance pain relief in animals administered NSAIDS, but help protect their intestinal tracts from ulcerations which are occasionally seen as a side effect of NSAID use.. Research in laboratory animals suggests that chondroitin dissolved in water before administration is more effective than when administered within a capsule.. ...
... are used to relieve pain and fever and to reduce swelling and inflammation caused by injury or diseases such as arthritis. Aspirin, ibuprofen, ketoprofen, and naproxen are commonly used NSAIDs. NSAIDs may cause side effects. The most common are stomach upset, heartburn, and nausea. NSAIDs may irritate the stomach lining. If the medicine upsets your stomach, you can try taking it with food. But if that doesnt help, talk with your doctor to make sure its not a more serious problem.. Frequent or long-term use of NSAIDs may lead to stomach ulcers or high blood pressure. They can also cause a severe allergic reaction. ...
Non-steroidal anti-inflammatory drugs (NSAIDs) have been implicated in the aetiology of acute renal failure (ARF), but epidemiological studies examining this association have produced disparate results. We conducted a case-control study using a purposebuilt record-linkage database for a population of 420 600 patients, resident in Tayside since May 1990. Patients (n = 207) hospitalized with a diagnostic code for ARF between 1990 and 1992 had their diagnosis validated by a renal physician. Six community controls and two hospital controls, matched for age and sex, were generated for each of these cases. Exposure to dispensed oral NSAIDs, topical NSAIDs and aspirin during the 90 days prior to the index date were investigated (recent exposure), as was exposure at any time since January 1989 (previous exposure). The most significant associations were modelled using conditional logistic regression. When community controls were used, recent exposure to NSAIDs and previous exposure to aspirin were ...
Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested a similar effect in pancreatic cancer. Cyclooxygenase-2 (COX-2), a major target of NSAIDs, is upregulated in pancreatic cancer and is associated with worse prognosis. COX-2 upregulation has been shown to correlate with angiogenesis and production of pro- angiogenic growth factors, especially Vascular Endothelial Growth Factor (VEGF), in several Gl cancers. Although this relationship between COX-2 and angiogenesis in pancreatic cancer would seem a viable target, clinical trials of COX-2 or VEGF inhibitors have demonstrated no survival benefit ...
Nitric oxide-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs) are a promising class of compounds that cause cell cycle perturbations and induce apoptosis in cell lines from different tumors. We investigated the activity of a recently developed NO-NSAID (NCX 4040) in bladder cancer cell lines (HT1376 and MCR). Cells were treated with different drug concentrations for different exposure times. Cytostatic and cytocidal activity was tested by SRB assay and apoptosis was evaluated by TUNEL analysis, ANNEXIN V assay and fluorescence microscopy. To further investigate the cell death-inducing mechanisms of NCX 4040, we analyzed gp-170, caspase expression and mitochondrial membrane potential (Delta Psi) depolarization. NCX 4040 showed a striking cytocidal activity in both cell lines, reaching LC(50) at a 10-mu M and 50-mu M concentrations in HT1376 and in MCR cells, respectively, after an exposure of only 6 h followed by an 18-h washout. Apoptosis was triggered in up to 90% of cells and was ...
Aspirin, naproxen, and other nonsteroidal anti-inflammatory drugs (NSAIDs) are promising chemopreventive agents for individuals at high risk for colorectal cancer (CRC). However, uptake of chronic and continuous NSAID administration to reduce CRC risk is limited by unwanted side effects. Employing novel dosing regimens and an azoxymethane-induced rat colon cancer model, Mohammed and colleagues found that intermittent use of either aspirin or naproxen was highly effective in preventing the progression of colonic adenoma to adenocarcinoma without serious side effects (see the study beginning on page 751). These findings could ultimately impact the standard of preventive care for patients at the adenoma stage (i.e., in high-risk cohorts) to protect against advancement to invasive adenocarcinoma with intermittent NSAID use. The micrograph on the cover depicts hematoxylin and eosin staining of rat colon crypt, hyperplasia, adenoma, and adenocarcinomas that recapitulate the histological progression of ...
The metabolic fate of nitric oxide (NO) released from nitroaspirin, benzoic acid, 2-(acetyloxy)-3-[(nitrooxy)methyl]phenyl ester (NCX 4016), the lead compound of a new class of NO-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs), has been studied in the rat following p.o. and i.p. administration of 100 mg/kg, by monitoring in plasma the bioactive storage forms of NO (S-nitrosothiols, RS-NO) and its oxidation products (nitrites/nitrates, NOx) by a chemiluminescent assay. In parallel, plasma was analyzed for unchanged drug and metabolites by reverse-phase HPLC. In orally treated rats, no unchanged drug is observed in the 0-24 h interval post-dosing, but only salicylic acid (SA), NOx and RS-NO. The time-course of SA formation parallels that of plasma NOx (plateau after 6 h). Nitrosothiols in plasma are detectable at 1 h, peak at 4 h post-administration, and decline thereafter. The results relative to i.p. administration show a more pronounced and rapid NO delivery (peak of both NOx and ...
Study objective To compare the efficacy of two MO administration-protocols: PCA MO (only) vs combination of continuous background infusion plus PCA MO (combined dosage) in patients after abdominal and thoracic surgery.. Methods Inclusion criteria The study will be conducted as a prospective, randomized, double blinded one, into which we will enroll patients aged 18-80 years undergoing major abdominal procedures (e.g. laparotomy, nephrectomy, gastrectomy, gastric bypass, pancreatectomy, splenectomy, and abdominal aortic aneurysm) or thoracic surgery (segmentectomy, lobectomy or pneumonectomy) in our institution during the years 2008-9.. Exclusion criteria We will exclude from the study patients with a history of drug or alcohol abuse, psychiatric disturbances, senile dementia, Alzheimers disease, seizures or suicide risk, use of psychotropic drugs, pregnancy or nursing, hypersensitivity to MO, or to non steroidal anti-inflammatory drugs (NSAIDs) or their excipients, chronic or acute pain of any ...
This study investigated the direct effects of non-steroidal anti-inflammatory drugs (NSAIDs) and atrial natriuretic peptide (ANP) on canine-derived vascular endothelial cells (VECs). viability (Fig. 3D). Open in a separate windows Fig. 3. Growth inhibitory curves of canine-derived VECs treated with meloxicam (A), carprofen (B), robenacoxib (C), and ANP (D). VEC viability decreased in a dose-dependent manner with NSAID treatment but was only marginally influenced by ANP. Previous studies have defined the lifestyle and isolation of canine VECs produced from arteries and blood vessels using collagenase [5, 10]. Inside our research, trypsin was employed for the intraluminal exfoliation of VECs from canine vessels due to the mRNA appearance Rabbit Polyclonal to hnRNP H of Compact disc31 as well as the positive recognition of surface Compact disc31 antigens. The canine-derived VECs attained by this technique should be designed for studies in the systems and jobs of VECs in the angiogenesis. ...
Shin splints" is a term to describe pain and swelling in the front of the lower legs. The pain usually appears after and is aggravated by repetitive activities such as running or walking. Contributing causes are flat feet, calf tightness, improper training techniques, worn out or improper shoes/sneakers, as well as running or walking on uneven surfaces. The inflammation in the shin results from the repeated pull of a muscle in the leg from the shin bone (tibia).. This condition usually occurs bilaterally (both legs) and can be alleviated by rest, use of non steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, icing, a change in training habits, stretching exercises, and properly fitted shoes. A foot and ankle surgeon can treat the condition, recommend proper shoe gear, and evaluate whether orthotics are needed. If not treated, shin splints may eventually result in a stress fracture of the shin bone.. ...
Some drug classes have been amalgamated from these three principles to meet practical needs. The class of nonsteroidal anti-inflammatory drugs (NSAIDs) is one such example. Strictly speaking, and also historically, the wider class of anti-inflammatory drugs also comprises steroidal anti-inflammatory drugs. These drugs were in fact the predominant anti-inflammatories during the decade leading up to the introduction of the term "nonsteroidal anti-inflammatory drugs". Because of the disastrous reputation that the corticosteroids had got in the 1950s, the new term, which offered to signal that an anti-inflammatory drug was not a steroid, rapidly gained currency.[4] The drug class of "nonsteroidal anti-inflammatory drugs" (NSAIDs) is thus composed by one element ("anti-inflammatory") that designates the mechanism of action, and one element ("nonsteroidal") that separates it from other drugs with that same mechanism of action. Similarly, one might argue that the class of disease-modifying ...
Some drug classes have been amalgamated from these three principles to meet practical needs. The class of nonsteroidal anti-inflammatory drugs (NSAIDs) is one such example. Strictly speaking, and also historically, the wider class of anti-inflammatory drugs also comprises steroidal anti-inflammatory drugs. These drugs were in fact the predominant anti-inflammatories during the decade leading up to the introduction of the term "nonsteroidal anti-inflammatory drugs". Because of the disastrous reputation that the corticosteroids had got in the 1950s, the new term, which offered to signal that an anti-inflammatory drug was not a steroid, rapidly gained currency.[4] The drug class of "nonsteroidal anti-inflammatory drugs" (NSAIDs) is thus composed by one element ("anti-inflammatory") that designates the mechanism of action, and one element ("nonsteroidal") that separates it from other drugs with that same mechanism of action. Similarly, one might argue that the class of disease-modifying ...
Inflammation is perhaps the most common cause of pain. Inflammatory reactions are major contributors to Alzheimers disease and to Atherosclerosis, including coronary heart disease. Free radicals and C-Reactive protein are the chief lab tests indicating an inflammatory response. Inflammation may occur because of an infection but also is a reaction to trauma and toxins. Anti-inflammatory drugs are increasingly being touted as useful in treating pain, as well as for preventing Alzheimers and coronary heart disease. Non-steroidal anti-inflammatory drugs are among the most widely OTC products. The "original", aspirin, or acetyl salicylic acid, is one of the best. Incidentally, its major "competitor", acetaminophen, is NOT anti-inflammatory. Acetaminophen does help reduce fever but, in my opinion, it is a lousy pain reliever. Acetaminophen is, in my opinion, not a drug worth taking! It has a much higher incidence of liver damage than the N-SAIDS. Other N-SAIDS, such as ibuprofen, ketoprofen, ...