Physiologically based pharmacokinetic (PBPK)/pharmacodynamic (PD) models can contribute to animal-to-human extrapolation and therapeutic dose predictions. Buagafuran is a novel anxiolytic agent and phase I clinical trials of buagafuran have been completed. In this paper, a potentially effective dose for buagafuran of 30 mg t.i.d. in human was estimated based on the human brain concentration predicted by a PBPK/PD modeling. The software GastroPlusTM was used to build the PBPK/PD model for buagafuran in rat which related the brain tissue concentrations of buagafuran and the times of animals entering the open arms in the pharmacological model of elevated plus-maze. Buagafuran concentrations in human plasma were fitted and brain tissue concentrations were predicted by using a human PBPK model in which the predicted plasma profiles were in good agreement with observations. The results provided supportive data for the rational use of buagafuran in clinic.

A novel indolamine derivative, ADN-2013, has been proved to possess a preclinical activity pro le appropriate for the treatment of behavioral and psychological symptoms of dementia. Its antidepressant and anxiolytic properties have been examined in rat and mice models. The receptor mechanisms underlying the antidepressant properties of ADN-2013 have also been elucidated. ADN-2013 signi cantly shortened the immobility time measured in the forced swim test in mice and rats, producing an e ect that was abolished by the dopamine D1-receptor antagonist SCH 23390 in rats. Moreover, ADN-2013 evoked anxiolytic-like activity in both conditional and unconditional anxiety-like paradigms in mice and rats. From these re- sults, it is likely that direct antagonism toward serotonin 5-HT6 receptors and an indirect e ect of dopamine, acting mostly via D1-like receptors, may be involved in the antidepressant action of ADN-2013. However, the partial agonist activity of ADN-2013 toward D2 receptors, observed in ...

You searched for: Language English Remove constraint Language: English Subject Hospitals, Psychiatric Remove constraint Subject: Hospitals, Psychiatric Subject Anti-Anxiety Agents Remove constraint Subject: Anti-Anxiety Agents ...

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Antidepressants, anxiolytics, psychostimulants, psychodysleptics Ján Mojžiš P.J. Šafárik University Faculty of Medicine Department of Pharmacology Košice http:en.wikipedia.orgwikiImage:Vincent_Willem_van_Gogh_002.jpg…

if you have acute anxiety (marked by panic attacks), you will likely need to take an anti-anxiety medicine as well. the most prominent of anti-anxiety drugs for the purpose of immediate relief are tho

Most orthopaedic injuries are caused by trauma which may require several surgical interventions. Such patients experience pains that may generate anxiety disorders. Anxiolytic drugs are Most orthopaedic injuries are caused by trauma which may require several surgical interventions. Such patients experience pains that may generate anxiety disorders. Anxiolytic drugs are essential in the management of cases where anxiety and insomnia are likely to be found. This study was therefore carried out to determine the prescription pattern of these anxiolytic drugs for orthopaedic patients in comparison with other prescribed drugs. The study also set out to determine which of the anxiolytics was prescribed most. The study was done retrospectively by evaluating anxiolytics prescribed in the patients medical folders at National Orthopaedic Hospital Enugu, Nigeria, within 2000 and 2004, using WHO Prescription Indicator Manual. F- distribution statistical tool was used to compare the anxiolytics prescribed ...

There are several different classes of anxiolytic drugs, including benzodiazepines, antidepressants, certain beta-blockers, and...

Lena Dunham has been sober for six months after “misusing” anti-anxiety drug Klonopin.The Girls creator and star began using the powerful medication to help her cope with anxiety when she would have to “show up for things that (she) didn’t feel equipped to show up for,”...

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RESULTS: OXY at the dose 0.05 mg/kg increased locomotion indicating anxiety attenuation, but 1.0 mg/kg reduced both locomotion and rearing. CBT in the dose range 0.1-3.0 mg/kg either did not change or increased horizontal activity. The increase in exploration after both peptides persisted for several days. A marked difference in the behavioral effects of the two peptides was grooming enhancement induced by OXY compared with the absence of this effect after CBT. The increase of the activity induced by OXY and CBT indicating anxiolytic-like action was blocked by OXY antagonists. However, the reduction of exploration induced by 1.0 mg dose of OXY was only partially reversed. The OXY induced enhanced grooming was completely antagonized by all used antagonists ...

Treatment for a Xanax addiction involves countering the addiction on two fronts: the physical compulsion for the client to take Xanax and the mental craving for more of the drug.To address the first front, a client will undergo medical detox, with the goal of weaning off Xanax with as little distress as possible. Since the effects of withdrawal can be very painful and traumatic, treatment center staff might prescribe a course of anti-anxiety and anticonvulsant medication. Ironically, benzodiazepines are effective in the treatment of withdrawal symptoms,in the words of American Family Physician.. Due to the administration of anti-anxiety drugs being performed by trained staff members in a controlled environment (who have a full understanding of the clients medical history and toxicology), a client can be put on a drug regimen to ease the withdrawal process, while incurring as minimal risk as possible. This is also why withdrawal should never be attempted alone, as the risk for relapsing and ...

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Bromantane is a drug that is somewhat of an anomaly in the world of stimulants, as it is purported to possess both stimulant and anxiolytic properties.

A recent study identified FAAH as a critical molecule involved in mood control in humans, showing that carriers of an FAAH gene mutation with reduced enzyme activity had both decreased threat-related brain reactivity and reduced anxiety (Hariri et al., 2009). These findings are particularly relevant because they allow generalizing to humans the results of the existing literature on the antianxiety effects of reduced FAAH activity in rodents. Both genetic and pharmacological inactivation of FAAH, in fact, exerts anxiolytic and antidepressant actions in rodents (Kathuria et al., 2003; Gobbi et al., 2005; Patel and Hillard, 2006; Bortolato et al., 2007; Hill et al., 2007; Naidu et al., 2007; Cippitelli et al., 2008; Moreira et al., 2008; Rubino et al., 2008; Scherma et al., 2008; Haller et al., 2009; Micale et al., 2009, and does not cause sedation, hypothermia, hyperphagia, or abuse potential (Fegley et al., 2005; Gobbi et al., 2005; Lichtman and Martin, 2005), which are important side effects of ...

A 2013 study set out to assess the impact of CBD in smokers who wished to stop smoking. Preliminary findings from a 2013 study showed that CBD significantly reduced the number of cigarettes smoked by ~40% during treatment. This preliminary data suggest CBD to be a potential treatment for nicotine addiction. (SOURCE).. A 2015 review discussed how CBD appears to have low reinforcing properties with limited abuse potential. CBDs anxiolytic properties and minimal adverse side effects also support its potential viability as a treatment option for a variety of symptoms associated with drug addiction. The study concluded that evidence supports potential beneficial treatment for opioid abuse. Patients with substance disorders usually have various psychiatric and medical symptoms that are reduced by CBD - symptoms such as anxiety, mood symptoms, insomnia, and pain so treating them with CBD might be beneficial for treating opioid -dependent individuals. CBD could offer a novel line of research medication ...

Over-the-counter pain relievers like Tylenol can be the number one cause of pet poisoning. The drug is an antidepressant with anxiolytic properties. The… Check it out to find out which career among these suits you the best depending upon your specific interest and academic qualifications. There are a few tests with which the level of depression and existence of depression can be assessed. The rheumatologist salary range varies considerably based on specialization and experience. http://youtube.com/watch?feature=player_embedded&v=bN1f1rs_q2cIf you have elevated levels of cholesterol, it is possible your doctor may have prescribed the drug simvastatin. The main determinants of the salary of a cardiovascular technologist are the specialization and place of employment. If the patient does not respond well to the medicines administered internally and externally, then the sores are treated with photo therapy. There are many radioactive neutron rich and proton rich isotopes that are made in nuclear ...

Johnson, M., Hitchcock, G., Godwin, S., Leiter, E., Sedgwick, W., and Jones, W., (Apr 2011 ). Evaluation of the Anxiolytic Properties of Myristicin, a Nutmeg Extract, in the Male Sprague-Dawley Rat. ANNA Journal.. Honors and Awards: ...

Publication Details (including relevant citation information): Alt, Andrew, Weiss, Brianne, Ornstein, Paul L., Gleason, Scott D., Bleakman,

Congratulations! You have found the Anxiolytic Forum on Forum Jar. This forum is a place where people who are interested in Anxiolytic come together and discuss about Anxiolytic. Please use the message board below to post anything related to Anxiolytic . If you are interested in other similar forums, please check out the Related Forums section on the right. If you like this forum, please dont forget to tell your friends about Forum Jar ...

A threshold level of activating b1 receptors with known sedatives and novel compounds caused rotarod failure, measured as a sign of sedation. Compounds with b1 activity below that threshold of 80% modulation of GABA EC10 currents in electrophysiology did not cause rotarod deficits. Testing of the non-sedative compounds in mouse light-dark transition test and the rat elevated plus maze anxiety paradigms show these compounds to be non-sedative anxiolytics. This new model of β1 activation is more accurate for predicting sedative liability and could have profound impact in anxiolytic drug discovery methods. ...

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ANXIOLYTICS answers are found in the Harrisons Manual of Medicine powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.

This category is for medications used to treat anxiety (including panic), stress, agitation, and sometimes insomnia. The principal group of drugs used for this purpose are sedatives in the benzodiazepine group. SSRIs also are prescribed for treatment of anxiety.

In order to manage my depression, I know I have to be vigilant about managing my stress and anxiety as well. When anxiety is building, I know its just a short trip to crazy town. When anxiety starts knocking on my door, I get right on it, and focus on to supporting my bodys ability…

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...

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This Drug Abuse Warning Network (DAWN) short report looks at the estimated number of emergency room visits for adverse reactions involving involving the prescription sleep qie zolpidem for 2005 through 2010. The report focuses on gender, age groups and other pharmaceuticals such as pain relievers, other anti-anxiety and insomnia medications.... ...

This Drug Abuse Warning Network (DAWN) short report looks at the estimated number of emergency room visits for adverse reactions involving involving the prescription sleep qie zolpidem for 2005 through 2010. The report focuses on gender, age groups and other pharmaceuticals such as pain relievers, other anti-anxiety and insomnia medications.... ...

The use of antidepressants has rocketed in recent years despite the ambivalence that many people have about taking such medications. The same holds true for anti-anxiety medication.

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Terpenes have a wide range of health benefits. Research has shown terpenes have anti-anxiety, anti-cancer, anti-inflammatory, and analgesic properties.

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While expert recommendations caution against long-term benzodiazepine use in the elderly, survey data suggest increasing benzodiazepine use with age. Computerized pharmacy records of staff-model HMO were used to examine benzodiazepine prescribing. Six-month prevalence of benzodiazepine use 2.8% and prevalence of continued use 0.7% were lower...

Moderate-to-large weighted effect sizes were found for all cognitive domains suggesting that long-term benzodiazepine users were significantly impaired, compared with controls, in all of the areas that were assessed. However, this study has several limitations, one being that it includes a relativel …

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Problem benzodiazepine use can be associated with various deviant behaviors, including drug-related crime. In a survey of police detainees carried out by the Australian Government, both legal and illegal users of benzodiazepines were found to be more likely to have lived on the streets, less likely to have been in full-time work and more likely to have used heroin or methamphetamines in the past 30 days from the date of taking part in the survey. Benzodiazepine users were also more likely to be receiving illegal incomes and more likely to have been arrested or imprisoned in the previous year. Benzodiazepines were sometimes reported to be used alone, but most often formed part of a poly drug-using problem. Female users were more likely than men to be using heroin, whereas male users were more likely to report amphetamine use. Benzodiazepine users were more likely than non-users to claim government financial benefits and benzodiazepine users who were also poly-drug users were the most likely to be ...

Methods: 30 Swiss albino mice were divided into 5 groups with 6 mice in each group. The study was conducted in two phases to evaluate acute and chronic effects. The groups consisted of diazepam (1 mg/kg), 3 doses of nifedipine (2.6 mg/kg, 5.2 mg/kg and 10.4 mg/kg) and vehicle control. The Elevated Plus Maze (EPM) and Light and Dark box were used to evaluate the anti-anxiety effects. The number of entries and time spent in the open arm of the elevated plus-maze and in the light area of light and dark box model were noted and compared among the 5 groups. Observations were analyzed using ANOVA and post hoc Tukeys test. ...

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A single exposure to the elevated plus-maze (EPM) test of anxiety reduces or abolishes the anxiolytic efficacy of benzodiazepines on a second trial. Some possible explanations to the occurrence of this phenomenon (one-trial tolerance-OTT) involve behavioral modifications thought to be consequence of some kind of learning in the first trial. in the present study, the influence of learning-impairing situations on the effects of the benzodiazepine chlordiazepoxide on mice re-tested in the EPM is investigated. the results showed that: (1) as expected, the administration of chlordiazepoxide to mice re-tested in the EPM- under the same conditions of the first trial- failed to induce anxiolysis; (2) a decreased percent time in the open arms was observed on the second trial of mice exposed to both trials under the same experimental conditions; (3) neither the increase in open arm avoidance by mice re-exposed to the EPM nor the OTT to chlordiazepoxide effect were modified by administration of the ...

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The Mechanism of Brain-Disability Neurophysiological studies show that the benzodiazepines potentiate the neuronal inhibition that is mediated by gamma-aminobutyric acid (GABA). In doses used clinically, this results in a generalized suppression of both spontaneous and evoked electrical activity of the large neurons throughout all regions of the brain and spinal cord (Ballenger, 1995). The binding of benzodiazepines to the GABA receptors is most intense in the cerebral cortex. Some benzodiazepines, such as Xanax and Halcion, bind especially tightly, increasing their tendency to produce more intense sedation and hypnosis, and also more severe cognitive deficits, behavioral abnormalities, rebound, and withdrawal. Some advocates of the benzodiazepines have argued for a specific anti-anxiety effect separate from the general sedative effect, but theres no substantial evidence for this.. Rall (1990) concludes: The question whether the so-called antianxiety effects of the benzodiazepines are the same ...

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Several cross-sectional studies have found cognitive impairment in subjects taking benzodiazepines for long periods. However, it is not known whether long-term use of benzodiazepines accelerates cognitive decline in the elderly. The authors addressed this issue in a follow-up study of 1,389 people a …

Anti-anxiety drugs and sleeping pills have been linked to an increased risk of death, according to new research from the University of Warwick. The large

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We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects in an open field, light-dark box, and novel object recognition tests under oral administration for acute and sub-acute treatment. We tested the VBZ102 toxicity in mice through a determination of LD,sub,50,/sub, values and examination of the biochemical and histopathological parameters. The VBZ102 induced an anxiolytic effect at different doses both in the light-dark box and open field tests. Unlike other benzodiazepines (e.g., bromazepam), a sedative effect was noted only after administration of the VBZ102 at 10.0 mg/kg ...

ALP Alprazolam is a drug of Anti-Anxiety category. You can see details and related ALP Alprazolam in same (condition) category written below.. Anti-Anxiety:. The unpleasant emotional state consisting of psychophysiological responses to anticipation of unreal or imagined danger, ostensibly resulting from unrecognised intrapsychic conflict.. Physiological concomitants include increased heart rate, altered respiration rate, sweating, trembling, weakness and fatigue, psychological concomitants include feelings of impending danger, powerlessness, apprehension and tension.. Want Anti-Anxiety medication? You can buy ALP Alprazolam online here.. Many different types of medications are used in the treatment of anxiety disorders, including traditional anti-anxiety drugs such as benzodiazepines, and newer options like antidepressants and beta-blockers.. ...

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An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety. This effect is in contrast to anxiogenic agents, which increase anxiety. Together these categories of psychoactive compounds or interventions may be referred to as anxiotropic compounds or agents. Some recreational drugs such as alcohol (also known formally as ethanol) induce anxiolysis initially; however, studies show that many of these drugs are anxiogenic. Anxiolytic medications have been used for the treatment of anxiety disorder and its related psychological and physical symptoms. Anxiolytics have been shown to be useful in the treatment of anxiety disorder. Light therapy and other interventions have also been found to have an anxiolytic effect. Beta-receptor blockers such as propranolol and oxprenolol, although not anxiolytics, can be used to combat the somatic symptoms of anxiety such as tachycardia and palpitations. Anxiolytics are also known as minor tranquilizers. The term ...

Estazolam (desmethylalprazolam, marketed under the brand names ProSom, Eurodin) is a benzodiazepine derivative drug developed by Upjohn in the 1970s. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Estazolam is an intermediate-acting oral benzodiazepine. It is commonly prescribed for short-term treatment of insomnia. Estazolam is prescribed for the short-term treatment of certain sleep disorders. It is an effective hypnotic drug showing efficacy in increasing the time spent asleep as well as reducing awakenings during the night. Combination with non-pharmacological options for sleep management results in long-term improvements in sleep quality after discontinuation of short-term estazolam therapy. Estazolam is also sometimes used as a preoperative sleep aid. It was found to be superior to triazolam in side effect profile in preoperative patients in a trial. Estazolam also has anxiolytic properties and due to its long half life can be an ...

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To read summaries of all international warnings and studies on anti-anxiety drugs (Klonopin is an anti-anxiety drug) click here for Anti-Anxiety Drug Side

Albizzia julibrissin Durazz, a Chinese Medicine, is commonly used for its anti-anxiety effects. (-)-syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside (SAG) is the main ingredient of Albizzia julibrissin Durazz. The present study investigated the anxiolytic effect and potential mechanisms on the HPA axis and monoaminergic systems of SAG on acute restraint-stressed rats. The anxiolytic effect of SAG was examined through an open field test and an elevated plus maze test. The concentration of CRF, ACTH, and CORT in plasma was examined by an enzyme-linked immune sorbent assay (ELISA) kit while neurotransmitters in the cerebral cortex and hippocampus of the brain were examined by High Performance Liquid Chromatography (HPLC ...

p,In considering the characteristics of the action of anxiolytic drugs and their mechanism in the brain, it may be necessary not only to study the behavioral pharmacology but also to perform brain site research. In the present study, the action of anxiolytic drugs was examined with respect to various behaviors that were induced by stimulating the brain areas related to emotions such as reward (pleasure) or aversion in rats. First, the low rate of response in lateral hypothalamic self-stimulation behavior was induced by schedules of low current brain stimulation, variable interval (VI) and differential reinforcement of low rate (DRL). Anxiolytic drugs such as benzodiazepines facilitated these low-rate responses. The drug susceptibility was highest in the low current stimulation, lower in the VI stimulation, and lowest in the DRL stimulation schedules. Furthermore, it was found by the auto-titration method in intracranial self-stimulation behavior that anxiolytic drugs decreased the threshold of ...

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Feature :. GABAA receptors containing the H101R point mutation are insensitive to modulation by benzodiazepines such as diazepam. In GABRA2-H101R mice, the anxiolytic-like action of diazepam and in part its myorelaxant action are missing.. ...

Chlordiazepoxide addiction treatment can help a person who has been abusing the drug kick the habit and live a healthy, sober life. Even though the effects of chlordiazepoxide addiction are not as physically debilitating as the effects of other drugs in this class, many people on chlordiazepoxide will benefit from professional help to address the root causes of addictive behavior.. Studies have shown that relatively few people with a legitimate prescription for chlordiazepoxide abuse the drug in the ordinary course of treatment. An individual can develop a physical dependency on chlordiazepoxide, however, even when the drug is used in the short-term and as prescribed. The person in this situation is not addicted to the drug, but this physical dependency may result in the manifestation of withdrawal symptoms if the drug is stopped abruptly.. Supervised withdrawal through a chlordiazepoxide detox program may be necessary to safely discontinue the use of the drug. Any abuse of chlordiazepoxide for ...

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The advent of palliative care played an important role in widening the appropriate use of opioid analgesics. The relatively high level of benzodiazepine prescriptions in our study suggests that the same is happening here. Protocols for the use of benzodiazepines in other healthcare settings emphasize the need for short courses, low doses and the avoidance of as required prescriptions. There is little evidence for long term efficacy, but with a median stay under the hospices care of just over three months, relatively few of our patient group could be said to have long term benzodiazepine use unless they had been taking this class of drug prior to hospice referral. Indeed, the fact that half of all benzodiazepine use was within the last three weeks of life and by a parenteral route implies that the patient group under consideration here is different from those with which usual guidance for benzodiazepine use is concerned. The relevance of benzodiazepine protocols to palliative care settings ...

A powerful anti-anxiety drug has been involved in a rising number of heroin-related deaths (HRDs) in Victoria in recent years, according to new research.. In a paper published in the Medical Journal of Australia today, researchers from Monash University called for the prescription and scheduling of the benzodiazepine alprazolam to be examined, after their study uncovered a dramatic increase in the supply of this drug, and detection in a rising rate of HRDs.. The findings come weeks before the Therapeutic Goods Association is due to meet to discuss whether more restrictions should be placed on the availability of benzodiazepines.. Alprazolam is a psychoactive drug approved for the short-term treatment of anxiety and panic disorder in Australia. Alprazolam is not recommended as a firstline treatment for these conditions due to concern about dependence, the potential for its misuse and because non-pharmaceutical interventions, such as cognitive behavioural therapy, have been found to be more ...

Buy Lexotanil 3mg (bromazepam). Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam (Valium). In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets.. Bromazepam is contraindicated and should be used with caution in women who are pregnant, the elderly, patients with a history of alcohol or other substance abuse disorders and children. Prolonged use of bromazepam causes tolerance and may lead to both physical and psychological dependence on the drug, and as a result, it is a medication which is controlled by international law.. ...

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Although the benzodiazepines have been the treatment of choice for anxiety disorders for many years, unfavorable aspects to their side-effect profile have initiated efforts to develop new-generation antianxiety agents. Over the past decade, scientists have been searching for compounds that retain the robust anxiolytic efficacy of benzodiazepines, but lack a number of unwanted properties, including… Read More ». ...

Researchers have found that lack of a brain protein makes mice notably less anxious and may extend the findings to humans with anxiety disorders.

A new study has found that an anxiety reducing drug that is finding its way into lakes and rivers is increasing the life span of certain fish.

Psychology Definition of SEDATIVE, HYPNOTIC, OR ANXIOLYTIC DEPENDENCE: In DSM-IV-TR, array of mental, behavioral, and physiological signs or symptoms suggesting continual consumption of sedative, hypnotic, or anxiolytic drugs

Fingerprint Dive into the research topics of Impact of benzodiazepines on functional outcome and occurrence of pneumonia in stroke: Evidence from VISTA. Together they form a unique fingerprint. ...

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While benzodiazepines act as sedatives AND anti-anxiety drugs, some are highly targeted at areas within the brain which focus on sleep. Others act in a more specific way and target fear centers in the brain. In most cases, higher doses act as sedatives and induce sleep, while in lower doses, they reduce anxiety without sedation. Benzodiazepines are also Central Nervous System (CNS) depressants (i.e. there can be a decline in blood pressure and breathing). It is important to note that they shouldnt be mixed with other CNS depressants such as alcohol. Its important that you utilize the dose your dentist or doctor recommends. It is possible to overdose, and overdoses could lower your breathing to dangerously low levels, which could result in coma or death. Please note that you shouldnt travel on your own after youve taken any of these drugs. Make sure you have an escort, even if you traveled by bus or foot! Its easy to become disorientated.. ...

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NovaDel Pharma was developing a lingual spray formulation of alprazolam for the treatment of anxiety disorders. Alprazolam is an anxiolytic agent marketed by