SUMMARY: A series of 76 mutants of Streptomyces coelicolor A3(2) specifically blocked in the synthesis of the binaphthoquinone antibiotic actinorhodin were classified into seven phenotypic classes on the basis of antibiotic activity, accumulation of pigmented precursors or shunt products of actinorhodin biosynthesis, and cosynthesis of actinorhodin in pairwise combinations of mutants. The polarity of cosynthetic reactions, and other phenotypic properties, allowed six of the mutant classes to be arranged in the most probable linear sequence of biosynthetic blocks. One member of each mutant class was mapped unambiguously to the chromosomal linkage map in the short segment between the hisD and guaA loci, suggesting that structural genes for actinorhodin biosynthesis may form an uninterrupted cluster of chromosomal genes.
For the parent molecule 9,10-antraquinone, see anthraquinone Anthraquinones (also known as anthraquinonoids) are a class of naturally occurring phenolic compounds based on the 9,10-anthraquinone skeleton. A type II polyketide synthase is responsible for anthraquinone biosynthesis in the bacterium Photorhabdus luminescens. Chorismate, formed by isochorismate synthase in the shikimate pathway, is an important precursor of anthraquinones in Morinda citrifolia. 0.5g of plant extract is shaken with 10 ml of benzene and filtered. 5ml of 10% ammonia is added to the filtrate. The mixture is shaken and the presence of pink, red or violet colour indicates the presence of anthraquinones. Hypericin and fagopyrin are naphthodianthrones, anthraquinone-derivatives. Many quinones are stable in multiple redox states; as such they can absorb electrons when appropriate counterions are available to maintain the bulk neutrality of the material. As such, 2,6-dihydroanthraquinone can be used as a negative electrolyte ...
Naturally occurring anthraquinones, damnacanthal (1) and nordamnacanthal (2) were synthesized with modified reaction steps and investigated for their cytotoxicity against the MCF-7 and K-562 cancer cell lines, respectively. Intermediate analogues 2-bromomethyl-1,3-dimethoxyanthraquinone (5, IC50 = 5.70 ± 0.21 and 8.50 ± 1.18 µg/mL), 2-hydroxymethyl-1,3-dimethoxyanthraquinone (6, IC50 = 12.10 ± 0.14 and 14.00 ± 2.13), 2-formyl-1,3-dimethoxyantharquinone (7, IC50 = 13.10 ± 1.02 and 14.80 ± 0.74), 1,3-dimethoxy-2-methylanthraquinone (4, IC50 = 9.40 ± 3.51 and 28.40 ± 2.33), and 1,3-dihydroxy-2-methylanthraquinone (3, IC50 = 25.60 ± 0.42 and 28.40 ± 0.79) also exhibited moderate cytotoxicity against MCF-7 and K-562 cancer cell lines, respectively. Other structurally related compounds like 1,3-dihydroxyanthraquinone (13a, IC50 = 19.70 ± 0.35 and 14.50 ± 1.28), 1,3-dimethoxyanthraquinone (13b, IC50 = 6.50 ± 0.66 and 5.90 ± 0.95) were also showed good cytotoxicity. The target compound ...
4-Deoxybostrycin is a natural anthraquinone compound isolated from the Mangrove endophytic fungus Nigrospora sp. collected from the South China Sea. Nigrosporin is the deoxy-derivative of 4-deoxybostrycin. They were tested against mycobacteria, especially Mycobacterium tuberculosis. In the Kirby-Bauer disk diffusion susceptibility test, they both had inhibition zone sizes of over 25 mm. The results of the absolute concentration susceptibility test suggested that they had inhibitory effects against mycobacteria. Moreover, 4-deoxybostrycin exhibited good inhibition which was even better than that of first line anti-tuberculosis (TB) drugs against some clinical multidrug-resistant (MDR) M. tuberculosis strains. The gene expression profile of M. tuberculosis H37Rv after treatment with 4-deoxybostrycin was compared with untreated bacteria. One hundred and nineteen out of 3,875 genes were significantly different in M. tuberculosis exposed to 4-deoxybostrycin from control. There were 46 functionally known
The autophagy of human prostate cancer cells (PC3 cells) induced by a new anthraquinone derivative, 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate (PA) was investigated, and the relationship between autophagy and reactive oxygen species (ROS) generation was studied. The results indicated that PA induced PC3 cell death in a time- and dose-dependent manner, could inhibit PC3 cell growth by G1 phase cell cycle arrest and corresponding decrease in the G2/M cell population and induced S-phase arrest accompanied by a significant decrease G2/M and G1 phase numbers after PC3 cells treated with PA for 48 h, and increased the accumulation of autophagolysosomes and microtubule-associated protein LC3-ll, a marker of autophagy ...
Name: 1-Amino-4-bromo-5-acetamido-2-anthraquinone sulfonic acid CA Name: 2-Naphthalenesulfonic acid,5-(acetylamino)-1-amino-4-bromo-9,10-dihydro-9,10-dioxo,monosodium salt Molecular Structure: 1-Amino-4-bromo-5-acetamido-2-anthraquinone sulfonic acid,2-Naphthalenesulfonic acid,5-(acetylamino)-1-amino-4-bromo-9,10-dihydro-9,10-dioxo,monosodium salt,CAS 86277-89-6,439.24,C16H11BrN2O6S 1-Amino-4-bromo-5-acetamido-2-anthraquinone sulfonic acid,2-Naphthalenesulfonic acid,5-(acetylamino)-1-amino-4-bromo-9,10-dihydro-9,10-dioxo,monosodium salt,CAS 86277-89-6,439.24,C16H11BrN2O6S Molecular Formula:C16H11BrN2O6S Molecular Weight: 439.24 CAS Registry Number: 86277-89-6
The effects of 1,8-dihydroxyanthraquinone (DHAQ), a stimulant laxative named danthron, on cell kinetics and prostaglandin (PG) biosynthesis in the gastrointestinal tract were investigated in male 8-week-old F344 rats divided into three groups, each consisting of 10 animals. The animals in groups one, two and three were respectively given diets supplemented with 0%, 0.1% and 0.2% DHAQ for 24 days. PGE2 levels in the colorectal mucosa were significantly (P , 0.05 and 0.001) elevated after DHAQ treatment and showed some evidence of a dependence of DHAQ dose, consistent with the plasma PGE2 levels. BrdU-labeling indices in the large intestinal epithelium were also significantly (P , 0.01) increased, although the other portions of the gut such as the stomach and small intestine were not significantly affected. Excretion of the main urinary metabolite of PGE (PGE-MUM) was significantly (P , 0.001 or 0.01) increased whereas the urinary PGE2 concentration and total PGE2 excretion were not changed. Thus ...
Rhubarb, a well-known Chinese herbal medicine, is also used in Europe and other places of the world. Anthraquinones derivatives are thought to be the major active components. A pressurized liquid extraction (PLE) and capillary zone electrophoresis (CZE) separation were developed for simultaneous determination of five anthraquinones including aloe-emodin, emodin, chrysophanol, physcion, and rhein in Rhubarb. The effects of the experimental variables on PLE and CZE have been optimized. The optimum conditions of PLE were: solvent, methanol; temperature, 1407C; particle size, 0.13-0.2 mm; static extraction time, 5 min; pressure, 1500 psi; and one extraction. The best separation of the five anthraquinones could be obtained using 50 mM borate buffer (pH 8.2) containing 25% isopropyl alcohol and 25% acetontrile as modifier, while the separation voltage was 25 kV and the temperature was at 207C. The method developed is accurate, simple, and reproducible, and could be used for quality control of Rhubarb ...
A set of aminoalkylamine substituted anthraquinones (AAQs) was successfully synthesised by aminating 1- or 1,5-chloroanthraquinones in a single reaction step. These substituted anthraquinones, 1C3 or 1,5C3, were tethered to minor groove binding polyamides with between 1 - 3 N-methyl pyrrole units (Py) to produce a library of Py-AAQ compounds. It was envisaged that these compounds could improve cytotoxicity through bimodal damage to DNA relative to the individual polyamide or AAQ moieties. A set of py-AAQ platinum complexes was also successfully synthesised by a platinum-mediated alkylamine to nitrile addition. The additional conjugation of a platinum nitrile complex to Py-AAQ conjugates was predicted to generate agents that are more cytotoxic than the Py-AAQ conjugates by damaging DNA via a minor groove binding (MGB)-intercalation-platination mechanism. All newly synthesised Py-AAQs and associated imino coordinated platinum(II) complexes were examined for cytotoxic activity in DLD-1 colon and ...
Disclosed are thermally-stable, anthraquinone colorant compounds (dyes) which contain one or more vinyl groups which render the compounds copolymerizable with reactive vinyl monomers to produce colored, polymeric compositions such as acrylate and methacrylate polymeric materials. The compounds possess good fastness (stability) to ultraviolet (UV) light, good solubility in vinyl monomers, good color strength and excellent thermal stability. Also disclosed are (1) coating composition comprising (i) one or more polymerizable vinyl compounds, (ii) one or more of the dye compounds described above, and (iii) a photoinitiator and (2) polymeric materials, i.e., polymers derived from one or more acrylic acid esters, one or more methacrylic acid esters, one or more other polymerizable vinyl compounds or mixtures of any two or more thereof, having copolymerized therein one or more of the anthraquinone colorant compounds.
A nonaqueous, hybrid metal-organic redox flow battery based on tailored anthraquinone structure is demonstrated to have an energy efficiency of ∼82% and a specific discharge energy density similar to those of aqueous redox flow batteries, which is due to the significantly improved solubility of anthraquinone
If you are willing to wholesale quality, advanced and durable the regenerated catalyst of hydrogen peroxide by anthraquinone from one of the famous China the regenerated catalyst of hydrogen peroxide by anthraquinone manufacturers, CHALCO is always at your service.
The report generally describes 9,10-anthraquinone monohydrazone, examines its uses, production methods, patents. 9,10-Anthraquinone monohydrazone market
ANTHRAQUINONE SALICYLIC ACID is an oral treatment. Learn more about Uses Side Effects Precautions and Brands of ANTHRAQUINONE SALICYLIC ACID.
[100 Pages Report] Check for Discount on Global Anthraquinone Sales Market Report 2017 report by QYResearch Group. In this report, the global Anthraquinone market is valued at...
The natural agent rhein is an ananthraquinone derivative of rhubarb, which has anticancer effects. To determine the mechanisms underlying the anticancer effects of rhein, we detected the effect of rhein on several oncoproteins. Here, we show that rhein induces β-catenin degradation in both hepatoma cell HepG2 and cervical cancer cell Hela. Treatment of HepG2 and Hela cells with rhein shortens the half-life of β-catenin. The proteasome inhibitor MG132 blunts the downregulation of β-catenin by rhein. The induction of β-catenin degradation by rhein is dependent on GSK3 but independent of Akt. Treatment of HepG2 and Hela cells with GSK3 inhibitor or GSK3β knockdown abrogates the effect of rhein on β-catenin. GSK3β knockdown compromises the inhibition of HepG2 and Hela cell growth by rhein. Furthermore, rhein dose not downregulate β-catenin mutant that is deficient of phosphorylation at multiple residues including Ser33, Ser37, Thr41 and Ser45. Moreover, rhein induces cell cycle arrest at S ...
Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain. Diacerein-containing medications are registered in some European Union and Asian countries and included as a treatment option on several international therapeutic guidelines. Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models. The most common side effects of diacerein treatment are ...
Chen, Xiaowen, Shengnan Peng, Huihong Zeng, Aixiang Fu, Qingxian Zhu (2015) Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. [Publication] Full text not available from this repository ...
Anthraquinone derivatives are most important class of a system that absorb in the visible region. Infrared and Raman spectroscopic analyses were carried out on 1,4-bis(4-formylphenyl)anthraquinone. The interpretation of the spectra was aided by DFT calculations of the molecule. The vibrational wavenumbers were examined theoretically using the Gaussian09 set of quantum chemistry codes, and the normal modes were assigned by potential energy distribution (PED) calculations. A computation of the first hyperpolarizability of the compound indicates that this class of substituted anthraquinones may be a good candidate as a NLO material. Optimized geometrical parameters of the compound are in agreement with similar reported structures. The HOMO and LUMO analysis is used to determine the charge transfer within the molecule. The stability of the molecule arising from hyper-conjugative interaction and charge delocalization has been analyzed using NBO analysis. (C) 2014 Elsevier B.V. All rights reserved. ...
anthraquinone: The most important quinone derivative of anthracene and the parent substance of a large class of dyes and pigments. It is prepared commercially by oxidation of anthracene or condensation...
China Pigment Blue 60 for Automobile Coating Plastic, Find details about China Anthraquinone Blue, Organic Pigment Blue from Pigment Blue 60 for Automobile Coating Plastic - Hangzhou Dimachema Imp & Exp Co., Ltd.
Detail záznamu - Anthraquinone as a Redox Label for DNA: Synthesis, Enzymatic Incorporation, and Electrochemistry of Anthraquinone-Modified Nucleosides, Nucleotides, and DNA - Detail záznamu - Knihovna Akademie věd České republiky
The influence of lithium ion pairing on the voltammetric reduction of anthraquinone in acetonitrile is reported. On gold electrodes, the single electron reduction generates a radical anion which forms a complex with lithium cations from the electrolyte. In situ ESR studies support this finding, and
2-(Chloromethyl)anthraquinone | C15H9ClO2 | CID 344311 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1,2-Anthraquinone | C14H8O2 | CID 101219 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Effects of Alkaline Sulfite Anthraquinone and Methanol Pulping Conditions on the Mechanical and Optical Paper Properties of Bamboo (Gigantochloa scortechinii)
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-),please inquire us for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-).
Spontaneously adsorbed monolayers, which are formed by the immersion o f an electrode into a dilute solution o f surface-active molecules have been studied extensively in recent years. The work presented in this thesis deals with the modification o f mercury electrode surfaces with 9,10-anthraquinone and two anthraquinone derivatives, 1-amino,2- sulphonic,4-hydroxyanthraquinone (1,2,4-AQASH), and 1,5-dimethoxyanthraquinone (1,5- DMAQ). These adsorbates form a n interaction with the electrode surface. The thermodynamics o f adsorption has been modeled using the Langmuir and Frumkin adsorption isotherms. Binary monolayers formed by the coadsorption o f 1,2,4-AQASH and 1,5-DMAQ have been investigated to probe the extent o f interaction between adsorbed moieties. The kinetics o f single component 1,5-DMAQ adsorption has been modeled over a wide concentration range to probe the mode o f adsorption o f these molecules. It has been concluded from the CV and kinetic fits o f this data that 1,5-DMAQ ...
... is an anthraquinone dye used with Disperse Red 9 in colored smoke to introduce a violet color. It is also used in dyes and marine flares . Synthesis 1,4-Diaminoanthraquinone is reacted with sodium dithionite to produce 1,4-diamino-2,3-dihydroanthraquinone. References Heyer, Thomas; Hans-Joachim Niclas, Stephan Dietzel (2010) 1,4-Diamino-2,3-dihydroanthraquinone is an anthraquinone dye used with Disperse Red 9 in colored smoke to introduce a violet color. It is also used in dyes and marine flares . Synthesis 1,4-Diaminoanthraquinone is reacted with sodium dithionite to produce 1,4-diamino-2,3-dihydroanthraquinone. References Heyer, Thomas; Hans-Joachim Niclas, Stephan Dietzel (2010) Express yourself. Organize your knowledge. Expand your mind. Discover the world. Revolvy connects you with interesting topics, lists and quizzes. Choose from hundreds of quizzes that test your knowledge. Search through millions of topics. Create a your personalized library of topics, and
29311-94-2 - SYZOCKFTUCTLFQ-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,4-bis((3-chloro-2-hydroxypropyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
55345-44-3 - QFYZUUMEXXFCKY-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,5-bis((4-phenoxyphenyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
In this in vitro study h-CLAT (Human Cell Line Activation Test), the skin sensitisation potential of the test item Mordand Red 11 was assessed according to the OECD 442E and under GLP without signiticant deviations. The in vitro h-CLAT enables detection of the sensitising potential of a test item by addressing the third molecular key event of the adverse outcome pathway (AOP), namely dendritic cell activation, by quantifying the expression of the cell surface markers CD54 and CD86 in the human monocytic cell line THP-1. The expression of these markers compared to the respective solvent controls is used to support discrimination between skin sensitisers and non-sensiters. In the present study, the test item was dissolved in DMSO. A dose finding assay was performed with stock solutions with concentrations ranging from 250 mg/mL to 1.96 mg/mL. The cells were treated with the different concentration and incubated for 24h at 37°C. After exposure, cells viability was measured by FACS ...
Groups of 10 male and 10 female F344/N rats were fed diets containing 0, 1,875, 3,750, 7,500, 15,000, or 30,000 ppm anthraquinone (equivalent to average daily doses of approximately 135, 275, 555, 1,130, or 2,350 mg anthraquinone/kg body weight) for 14 weeks. All rats survived until the end of the study. Mean body weights of females were significantly less in the exposed groups than in the control group. Feed consumption by the exposed and control groups was similar at the end of the study. Liver and kidney weights of exposed groups were greater than those of the controls, as were testis weights of males exposed to 7,500 ppm or greater. A minimal, responsive anemia was apparent in groups of male and female rats exposed to 3,750 ppm or greater by day 26 of the study. The anemia persisted and involved all exposed groups of rats at the end of the study. Renal function was also affected by anthraquinone exposure as demonstrated by increases in urine protein and glucose concentrations and aspartate ...
Anthraquinone-lectin hybrids were effectively synthesized using water-soluble anthraquinone derivative with concanavalin A (ConA) and hygrophorus russula lectin (HRL) to give anthraquinone-ConA () and anthraquinone-HRL (17) hybrids, respectively. These anthraquinone-lectin hybrids effectively and selectively degraded oligosaccharides containing a mannose residue as a non-reducing terminal sugar, which has affinity for ConA and HRL, under photo-irradiation with long-wavelength UV light without additives and under neutral conditions. In addition, anthraquinone-HRL (17) selectively photo-degraded only Man(α1,6)Man, which has a high affinity for HRL, among several mannosides by recognition of both the type and glycosidic linkage profile of the sugar in an oligosaccharide. ...
A series of 2,6-bis(arylethynyl)anthraquinones was prepared via double Sonogashira coupling to 2,6-diiodoanthraquinone, and characterized with regard to their optical and electronic properties. Substitution with a derivatized phenylethynyl group produced a lambda(onset) of 366 nm (E-g = 3.4 eV), but the more highly conjugated 2,6-bis(9′-anthracylethynyl)anthraquinones exhibited a lambda(onset) of approximately 540 nm (E-g = 2.3 eV). Poor solubility in the unsubstituted 9′-anthracylethynyl system hampered complete characterization or purification, but the 10′-hexanoylanthrac-9′-ylethynyl analog exhibited significantly better solubility. The preparation of several other functionalized derivatives was also explored, and key synthetic findings are reported ...
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99 EXPERIMENT: 88036 TEST: 03 TIME: 11:47:29 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036 PATHOLOGIST: SINGER, A. CAS: 84-65-1 ------------------------------------------------------------------------------------------------------------------------------------ 2 YEAR CHRONIC RATS REASONS FOR REMOVAL: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99 EXPERIMENT: 88036 TEST: 03 TIME: 11:47:29 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036 PATHOLOGIST: SINGER, A. CAS: 84-65-1 Rats(FISCHER 344) ----------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON ...
The present work reports a smart design of a chemodosimeter, namely 4-(6,11-dihydro-6,11-dioxo-1H-anthra[1,2-d]imidazol-2-yl)phenyl-4-nitrobenzenesulfonate (AH), which recognises F− specifically through a naked eye colour change from light yellow to light orange and remarkable ratiometric fluorescence from g
A 500-cc. three-necked flask fitted with a mechanical stirrer (Note 1) and a thermometer is half immersed in an oil bath mounted in a hood. In the flask are placed 120 g. of 19-22 per cent oleum and 1 g. of yellow mercuric oxide, the bath is warmed to 100°, and 100 g. (0.48 mole) of anthraquinone (Note 2) is added through a powder funnel attached by a piece of wide rubber tubing. The mixture is stirred vigorously and heated at 147-152° for forty-five to sixty minutes, after which the bath is removed and the flask is lowered from the stirrer and replaced by a 2-l. beaker containing 1 l. of hot water. While the water is being stirred, the hot acid solution is poured cautiously down the inner wall of the beaker; the mixture is then boiled for five minutes longer with stirring. After the unchanged anthraquinone (53-59 g.) (Note 3) is collected by suction on a 20-cm. Büchner funnel provided with a cotton filter cloth, it is washed with 200 cc. of hot water. The light brown filtrate, together with ...
This study attempted to screen selected phytochemicals in the ethanolic, methanolic and acetone extracts of Nonochlorum spp. The extracts were subjected to the following tests: Test tube method for Alkaloid Analysis (Confirmatory test, test for quaternary bases and/ or amine oxide), Test Tube Reaction Method for Steroids (Keller- Kiliani test: test for 2- deoxysugars), the Borntragers Test for Anthraquinones, Test tube Screening Methods for Flavonoids (Test for leucoanthocyanins: Bate- Smith and Metacalf method), and the Test tube Screening Method for Tannins (Ferric chloride test). Results showed that in all Nanochlorum spp. extract, steroids, anthraquinones and tannins were positive (with slight precipitation) but negative with alkaloids and flavonoids.. ...
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Piroxantrone, also known as CI942; PD111815, is a n anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity.
Information for Kiton Red S 3520-42-1 including Kiton Red S CAS NO 3520-42-1, Kiton Red S Suppliers, Kiton Red S Manufacturers, related products of Kiton Red S.
Weak Acid Green GW is an anthraquinone dye. This product appears as a green powder. It can be used in paints and inks. It can also be used to dye pap...
Principal molecular axis and transition dipole moment orientations in liquid crystal systems: an assessment based on studies of guest anthraquinone dyes in a nematic host
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RESULTS Diacerein reduced HbA1c compared with placebo by 0.35% (3.8 mmol/mol; P = 0.038) in the ITT analysis and by 0.41% (4.5 mmol/mol; P = 0.023) in the per-protocol analysis. The peak of effect occurred at the 24th week of treatment (−0.61% [6.7 mmol/mol; P = 0.014] and −0.78% [8.5 mmol/mol; P = 0.005], respectively), but it attenuated toward nonsignificant differences at the 48th week. No significant effect of diacerein was observed in other efficacy and safety measures. Diarrhea occurred in 65% of patients receiving diacerein and caused treatment interruption in 16%. Seven patients in the diacerein group reduced insulin dosage, whereas 10 in the placebo group increased it; however, mild hypoglycemic events were equally observed. ...
1. Berenbeim, J.A., Owens, S., Schmidt Patterson, C.M., de Vries, M.S., "Molecular Mechanisms of the Photostability of Common Madder Chromophores Alizarin and Purpurin and Hydroxy-Substituted Anthraquinones" Manuscript in Preparation. 2. Berenbeim, J.A., Siouri, F., Boldissar, S., Gate, G., Haggmark, M., Aboulache, B., Cohen, T., de Vries, M.S.,"Excited State Dynamics of Isocytosine; a Hybrid Case of Canonical Nucleobase Photodynamics" Manuscript Submitted. 3. Siouri, F., Boldissar, S., Berenbeim, J.A., de Vries, M.S., "Excited State Dynamics of 6-Thioguanine" J. Phys. Chem. 2017.. 4. Owens, S., Berenbeim, J.A., Ligare, M., Gulian, L., Siouri, F., Boldissar, S., Tyson-Smith, S., Wilson, G., Ford, A.,De Vries, M.S., "Direct Analysis of Xanthine Stimulants in Archaeological Vessels by laser desorption REMPI" Anal. Chem. 2017.. 5. Owens, S. C., Berenbeim, J. A., Patterson, C. S., Dillon, E. P., de Vries, M.S., "Sub-Micron Proximal Probe Thermal Desorption and Laser Mass Spectrometry on Painting ...
Transparent Blue 2RA is a dye in the anthraquinone chemical family. This product appears as a blue powder. It can be used in plastics, transparent pai...
Name:C.I.Disperse Red 164,C.I. 607564 Molecular Structure: anthraquinones C.I.Disperse Red 164,C.I. 607564,CAS 80892-58-6,C20H13NO5,347.32,Kayalon Polyester Light Red BLF C.I.Disperse Red 164,C.I. 607564,CAS 80892-58-6,C20H13NO5,347.32 Molecular Formula:C20H13NO5 Molecular Weight: 347.32 CAS Registry Number: 80892-58-6
Name:C.I.Solvent Violet 37 Molecular Structure: anthraquinones Molecular Formula: Molecular Weight: CAS Registry Number:61969-50-4