A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA ...
0048] Chemotherapeutic agents include, but are not limited to, the following sub-classes of compounds: Antineoplastic agents such as: Acivicin; Aclarubicin; Acodazole Hydrochloride; Acronine; Adozelesin; Adriamycin; Aldesleukin; Altretamine; Ambomycin; Ametantrone Acetate; Aminoglutethimide; Amsacrine; Anastrozole; Anthramycin; Asparaginase; Asperlin; Azacitidine; Azetepa; Azotomycin; Batimastat; Buniodepa; Bicalutamide; Bisantrene Hydrochloride; Bisnafide Dimesylate; Bizelesin; Bleomycin Sulfate; Brequinar Sodium; Bropirimine; Busulfan; Cactinomycin; Calusterone; Caracemide; Carbetimer; Carboplatin; Carmustine; Carubicin Hydrochloride; Carzelesin; Cedefingol; Chlorombucil; Cirolemycin; Cisplatin; Cladribine; Crisnatol Mesylate; Cyclophosphamide; Cytarabine; Dacarbazine; DACA (N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide); Dactinomycin; Daunorubicin Hydrochloride; Daunomycin; Decitabine; Dexormaplatin; Dezaguanine; Dezaguanine Ifesylate; Diaziquone; Docetaxel; Doxorubicin; Doxorubicin ...
0363] In certain embodiments, the compounds of the present invention can be formulated in a pharmaceutical dosage form in combination with anticancer agents. Suitable anticancer agents include, but are not limited to, acivicin; aclarubicin; acodazole hydrochloride; acronine; adozelesin; aldesleukin; altretamine; ambomycin; ametantrone acetate; aminoglutethimide; amsacrine; anastrozole; anthramycin; asparaginase; asperlin; azacitidine; azetepa; azotomycin; batimastat; benzodepa; bicalutamide; bisantrene hydrochloride; bisnafide dimesylate; bizelesin; bleomycin sulfate; brequinar sodium; bropirimine; busulfan; cactinomycin; calusterone; caracemide; carbetimer; carboplatin; carmustine; carubicin hydrochloride; carzelesin; cedefingol; chlorambucil; cirolemycin; cisplatin; cladribine; crisnatol mesylate; cyclophosphamide; cytarabine; dacarbazine; dactinomycin; daunorubicin hydrochloride; decitabine; dexormaplatin; dezaguanine; dezaguanine mesylate; diaziquone; docetaxel; doxorubicin; doxorubicin ...
Pyrrolobenzodiazepines (PBDs) are a group of antitumor antibiotics that exert their biological activity by alkylation of guanine bases within the minor groove of double-stranded DNA through nucleophilic attack of the guanine amino group on the PBD imine functionality. In trying to increase both the binding strength and sequence selectivity for further enhancing their biological activity, PBDs were linked to additional DNA binding moieties. Preliminary DNA melting experiments partly also performed in our lab with a series of closely related PBD-naphthalimide and benzimidazole conjugates revealed extraordinary DNA-binding capability of hybrids PBD-NIM and PBD-BIMZ. These studies also indicated the favorable contribution of the piperazine structure on drug binding to the DNA duplex. Previously, in vitro cytotoxicity studies also showed promising antitumor activity of both compounds with PBD-BIMZ having the largest cytotoxic potential among various examined conjugates. In the present work, the ...
Several properties of the major proteins degraded during germination of spores of Bacillus cereus, Bacillus megaterium, and Bacillus subtilis have been compared. All of the proteins had low molecular weights (6,000 to 13,000) and lacked cysteine, cystine, and tryptophan. The proteins could be subdivided into two groups: group I (B. megaterium A and C proteins, B. cereus A protein, and B. subtilis alpha and beta proteins) and group II (B. cereus and B. megaterium B proteins and B. subtilis gamma protein). Species in group II had lower levels of (or lacked) the amino acids isoleucine, leucine, methionine, and proline. Similarly, proteins in each group were more closely related immunologically. However, antisera against a B. megaterium group I protein cross-reacted more strongly with the B. megaterium group II protein than with group I proteins from other spore species, whereas antisera against the B. megaterium group II protein cross-reacted most strongly with B. megaterium group I proteins. ...
Earlier today, Synaffix, a Netherlands based biotechnology company focusing on the development of industry-leading antibody-drug conjugate technology platforms, confirmed receiving a key patent covering its HydraSpace™ spacer technology. The patent was granted by the United States Patent and Trademark Office (US 9,636,421 B2).. This patent secures the companys end-to-end patent protection of its ADC technology platform. The Synaffix portfolio of patents covering the core areas of the companys ADC technology including GlycoConnect™, HydraSpace™ and metal-free click chemistry.. Synaffix HydraSpace is a compact and highly polar spacer, which is designed to enhance ADC stability (reduced aggregation) and expand the therapeutic index of an ADC, beyond what is achieved by GlycoConnect alone. The spacer was originally designed to enable efficient attachment of the most challenging hydrophobic payloads, such as pyrrolobenzodiazepines (PBDs), to an antibody. Additionally, the branching ...
More than 50 ancient and rare relics were uncovered in a tomb excavation in Guxian County, Anhui province. The 53-tomb complex is believed to have been under construction over many dynastic periods dating back to the Eastern Han Dynasty nearly 2,000 years ago. The tomb complex was discovered accidentally on a construction site. It contains over 50 brick tombs from the Eastern Han, Tang and Song dynasties.. Experts identified the type of people who were buried there.Zhao Lanhui, deputy researcher of the Bengbu Cultural Relics Institute, said, lying south to north would perhaps be people of four generations. Due to its size, we know the tombs come from the Song Dynasty. Its small with a simple style.. The tombs hold a unique character that were built in an animal shape.Though some tombs have been plundered over the years, precious relics have emerged, such as bronze mirrors, gold and silver garments, along with pottery boxes.Many people buried here were considered common people, until the ...
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The IUPHAR/BPS Guide to Pharmacology. CC-885 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
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マウス・モノクローナル抗体 ab16794 交差種: Rat,Hu,Mk 適用: IHC-P,IHC-Fr,Flow Cyt,ICC/IF…APC抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody…
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CC-10 was detected by Western Blot. As expected, SmallAir™ contained few Muc5-Ac positive cells (goblet cells). In contrast, CC-10 was not detected in MucilAir™. Instead, Muc-5Ac was highly expressed in MucilAir™.. ...
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(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione - Ontology Report - Rat Genome Database
A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
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The state government welcomes the process of investigation by the Nigeria Police, which is ongoing, to unravel the mystery behind the allegation and ensure the security of all the citizens of the state.. However, intelligence report at my disposal indicates plans by some supporters of Senator Dino Melaye to stage a protest at Aiyetoro-Gbedde, in support of the senator on Saturday.. I am equally aware that some hoodlums and thugs are being recruited within and outside the state to join in the protest. As much as we do not want the rights of the protesters inhibited, the implications of such a protest in the middle of investigations into the senators allegations may be grave, as some hoodlums may hijack the process to foment trouble and disturb public peace.. The security adviser said he was equally not unaware that some anti-Melaye group were also drumming up a counter protest of theirs on same day, stressing that these will likely lead to chaos, He said that he had already briefed the ...