The Mid-Atlantic Society of Toxicology will present a webinar on Regulatory Acceptance of Alternative Methods: Current Status and Future Directions. NICEATM Director Warren Casey will speak on Predicting in vivo effects using in vitro data: the future of alternatives. Other speakers include George DeGeorge of MB Research Labs, Rodger Curren of the Institute for In Vitro Sciences, and Thomas Hartung of the Johns Hopkins Center for Alternatives to Animal Testing. The webinar will be presented on May 14, 2015 from 10:00 a.m. to 12:00 p.m.. Full Details and Registraton ...

The validation and regulatory acceptance of non-animal alternative tests is critical to the adoption of more humane scientific methodologies. Virtually all federally funded research is paid for with your tax dollars. Two of the main funders of animal-based research in North America, the U.S. National Institutes of Health and the Canadian Institutes of Health Research, need to hear that you dont want your tax dollars used to underwrite animal experiments and urge them to stop requiring cruel and obsolete animal tests for pharmaceuticals and allow companies to substitute in vitro tests. (Government funded animal testing costs U.S. taxpayers $12 billion annually) Alternatives to animal tests are effective, reliable, affordable and humane. Proponents of non-animal testing methods in the scientific community have shown that these methods are quicker and cost-effective. Unlike crude, archaic animal tests, non-animal methods usually take less time to complete, cost only a fraction of what the animal ...

At the end of 1991, the Commission of the European Communities informed the Council of Ministers and the European Parliament of its decision to set up a European Centre for the Validation of Alternative Methods (ECVAM), in line with its responsibilities under Directive 86/609/EEC. The main goal of ECVAM is to coordinate, at the European level, activities designed to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals. ECVAM is assisted by a Scientific Advisory Committee representative of all parties concerned with the validation of alternative methods, namely the Member States, and European industries, animal welfare organizations and academia. ECVAM is currently establishing information services and a series of workshops, task forces and symposia. It supports interlaboratory pre-validation and formal validation studies, and will itself also be practically involved in ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Who Scientific Group On Cardiovascular D, author of Cardiovascular Disease Risk Factors: New Areas for Research (Technical…, on LibraryThing

As historic events go the approval of Osiris Pharmaceuticals stem cell treatment Prochymal in Canada, making it the first regulatory approval for the technology outside of China, received a relatively muted response both in the wider pharma community and the financial one.

Authors: S Fitzpatrick, M Wind, A Jacobs, D Hattan, J Kulpa-Eddy, V Malshet, M Mumtaz, M Snyder, D McCarley, S Morefield, C Sprankle, D Allen, W Stokes. Abstract - Poster - Text-only version of poster. Abstract Number 1810A: Establishment of the International Cooperation on Alternative Test Methods (ICATM) and Its Role in the Validation and Regulatory Acceptance of Globally Harmonized Safety Assessment ...

In order to evaluate water-insoluble chemicals using the skin model which is more similar to real skin and detectable interaction among three kind cells, we established a test method which is a three-dimensional human skin model consisting of normal fibroblasts, normal keratinocytes and normal dendritic cells utilizing a collagen vitrigel membrane (VG-KDF-Skin). Nine sensitizers and five non-sensitizers were then examined. After 24 hr, the amount of IL-1α and IL-4 release was measured, and then positive/negative outcomes were evaluated (VG-KDF-Skin method ...

AFC TOMATO CHEESE CORN SAUCE Cream corn and V-8 VEGETABLE JUICE lay the foundation for a multi-dimensional culinary experience! Smooth sensations all the way around! Who would think from two common ingredients such a surprise package could catapult itself into the world of animal-free cuisine! Anything is possible when you cook animal-free!! Makes 3 cups…

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has recommended a non-animal test method to identify estrogen agonist and antagonist activity. In addition to recommending the test, ICCVAM also found the method to provide a number of benefits over the method currently employed in the United States.

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has recommended a non-animal test method to identify estrogen agonist and antagonist activity. In addition to recommending the test, ICCVAM also found the method to provide a number of benefits over the method currently employed in the United States.

This notice announces the broadly applicable alternative test method approval decisions that EPA has made under and in support of New Source Performance Standards (NSPS) and the National Emission Standards for Hazardous Air Pollutants (NESHAP) in 2010.

THE BUSINESS TIMES Companies & Markets - CURRENT cancer screening methods are invasive and costly. Think of the mammographies, endoscopies, or biopsies that are presently done to detect cancer. Local biotechnology start-up Mirxes Pte Ltd is looking to revolutionise cancer detection methods by offering blood tests in place of current diagnostic methods to detect early stage cancer.. Read more at The Business Times.

In case of buried or semi soil-buried liquefied gas tanks, an inner coating is generally required (a water pressure test must also be conducted under certain circumstances). However, test procedures have been developed in recent years that allow these tanks to be tested, in many cases, without requiring the tanks to be opened. These test procedures involve a feed test and a sound emission test. The sound emission test is an alternative test procedure to detect changes in the material. This takes place by applying a load (pressure increase), which causes an emission of acoustic waves in the material. The feed test is also alternative test procedure. In this case, the effectiveness of the container insulation is tested. (The feed test also requires carrying out a random sound emission test for a reference test. The random noise emission test is carried out on 10% of these tanks in addition to the feed measurement that is carried out on 100% of these tanks.) Instead of coating the inner wall, an ...

Colonoscopies are highly effective screening tools used to detect colon cancer, rectal cancer, and other conditions. They are very safe, but not completely without risk. Learn more here.

Buy Products for non-animal specific by Shiny Hardware for your Non-Animal Specific from VioVet. FREE UK DELIVERY available over £29. Great prices and super easy to use website, see for yourself now.

As scientists around the world race to create COVID-19 therapeutics, the PETA International Science Consortium Ltd. -- an organization dedicated to promoting human-relevant, non-animal testing strategies -- has co-launched a free, publicly available six-part webinar series focusing on the applications and benefits of animal-free recombinant antibodies. Antibodies are molecules produced by an organisms immune system in order to fight viruses, bacteria, or other foreign particles in the body.

The Executive Committee continued its discussions on HCFC production sector issues in the open-ended contact group which was initially formed at the 55th Meeting. The contact group was able to make progress and reach consensus on several issues. In preparation for the 57th Meeting, the Fund Secretariat was requested to provide a summary of information publicly available on relevant elements of the operation of the clean development mechanism (CDM) and the amounts of HCFC-22 production available for credits as a first step. The Committee also decided to constitute and convene the production sector sub-group at the 57th Meeting to continue the discussion on HCFC production sector phase-out issues including: the practices and procedures laid out in decision 19/36; the calculation of HCFC production sector phase out costs; the encouragement of a synchronized production/consumption phase-out as part of the first HPMP; incentives for early phase-out of HCFC production and/or providing disincentives ...

Anyone who wishes to use live animals in research or teaching at Western University and its affliates must disclose all procedures in an approved Animal Use Protocol (AUP). All AUPs are reviewed by the ACC, consisting of animal-using researchers, research lab animal technicians, grad students, non-animal-using researchers, a veterinarian, and members of the community at large who have never worked in animal research. Any subsequent changes to the AUP post-approval must also be reviewed and approved by the ACC via Protocol Modification. For more information on Animal Use Protocols, please visit the ACC Website.. To begin an AUP at Western, please contact [email protected] for more information.. ...

To date, recombinant human TGF-β1 has only been expressed in mammalian cell lines. Our protein experts have optimised TGF-β1, allowing us to produce highly bioactive protein in an E. coli expression system. This allows us to produce the first truly animal-free TGF-β1 for chemically-defined stem cell media.. As with Qkines other products, we provide full quantitative bioassay and biochemical data. Qkines TGF-β1 PLUS has also been validated for its ability to effectively maintain iPSC pluripotency by the specialist stem cell biotechnology company, Stemnovate, Cambridge, UK.. Benefits:. ...

Animal cell culture for the production of viral vaccines has been performed for more than 50 years, and currently this technology is expanding rapidly to meet present and future demands of the health sector. The development and regulatory approval of continuous cell lines for manufacturing viral vaccines has brought numerous benefits to production processes. However, greater advances in the last decade have been achieved in mammalian cell production of biological therapeutics, including monoclonal antibodies, hormones, growth factors, cytokines and clotting factors. We and others have contributed to these upstream advances by improving cell culture media with the development of animal-free and chemically-defined recombinant protein supplements. The supplements we have developed include recombinant insulin-like growth factor-I (LONG®R3IGF-I), epidermal growth factor (LONG®EGF), transforming growth factor-á (LONG®TGF-á), transferrin (CellPrime™ rTransferrin AF), and albumin (CellPrime™ rAlbumin

Recombinant Mouse FGF-basic (Animal-Free) - FGF-basic, also known as FGFb and FGF-2, is a member of the fibroblast growth factor (FGF) family which includes 23 members.

Insulin-Like Growth Factor-I, Human, Recombinant, E. coli, Animal-Free CAS - Find MSDS or SDS, a COA, data sheets and more information.

In the EU and US regulators have noted this progress. In 2012 the European Medicines Agency (EMA) revised its concept paper on the replacement of animal studies with in vitro tests to more clearly define the process for regulatory acceptance of alternatives, recognizing the increased use of in vitro methods and the need for formal validation studies on some occasions, and proof of scientific validity on others. (Revised Concept paper on the need for revision of the position on the replacement of animal studies by in vitro models (CPMP/SWP/728/95). Regulatory bodies in the EU and US are both becoming increasingly favourable towards in vitro research, says ISAB in vitro manager Maria Malmlöf. She points out that regulatory change around in vitro testing has been slower in inhalation than other fields, given the notorious complexity of delivering drugs to the lung. Recent regulatory recommendations on, for example, the testing of biosimilars (low-cost generic copies of biologic drugs) ...

7/17/20 The United Kingdom reports a wealth of information every year on its use of animals in research. Every animal procedure must be categorized according to the overall purpose (and specific disease area or regulatory purpose if relevant), the genetic status of the animals and the severity of the procedure. Great Britain (England, Scotland and…

A new article by scientists at Unilever, a corporate member of the HTPC, describes several areas of safety science in which they are using a pathway-based approach to replace traditional animal tests with a combination of human cell-based in vitro assays and computational models. The article, Toxicity testing - non-animal approaches and safety science (by…

The U.S. Food and Drug Administrations insistence on keeping its 2007 predicate date has drawn protests not only from vapor companies but also from animal lovers.. Countless animals will suffer and die now that newer tobacco products, such as e-cigarettes, will be required to FDA approval in order to enter or remain on the market, wrote the People for the Ethical Treatment of Animals (PETA) in response the new regulations.. To obtain FDA approval, tobacco manufacturers will be required to show that their products reduce the risk to current tobacco users and do not increase the risk to non-users. In a guidance document accompanying the rule, the FDA encourages manufacturers of electronic nicotine-delivery systems to meet with its Center for Tobacco Products (CTP) early in the development process to discuss what, if any, animal testing the agency considers appropriate or whether non-animal tests may be acceptable.. The FDA has stated that animal tests will still be required for toxicological ...

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The Tox21 partner agencies work together to develop, validate, and translate innovative in vitro HTS methods to characterize the impact of chemicals on key steps in toxicity pathways.. Data collected in the Tox21 initiative has been used to prioritize uncharacterized compounds for regulatory testing using both traditional and novel test methods. To more broadly address challenges in the field of toxicology, in 2018 Tox21 released a new strategic and operational plan (Thomas et al. 2018) that expands the focus of its research activities. New focus areas include expanding its portfolio of alternative test systems, addressing technical limitations of in vitro test systems, curating legacy in vivo toxicity testing data, establishing scientific confidence in in vitro test systems, and refining alternative methods for characterizing pharmacokinetics and in vitro assay disposition. The eventual goal of Tox21 is to use HTS methods to generate data that will allow risk assessors to more accurately ...

Foods of non-animal origin (FoNAO) are consumed in a variety of forms, being a major component of almost all meals. These food types have the potential to be associated with large outbreaks as seen in 2011 associated with VTEC O104. In order to identify and rank specific food/pathogen combinations most often linked to human cases originating from FoNAO in the EU, a semi-quantitative model was developed using seven criteria: strength of associations between food and pathogen based on the foodborne outbreak data from EU Zoonoses Monitoring (2007-2011), incidence of illness, burden of disease, dose-response relationship, consumption, prevalence of contamination and pathogen growth potential during shelf life. The top ranking food/pathogen combination was Salmonella spp. and leafy greens eaten raw followed by (in equal rank) Salmonella spp. and bulb and stem vegetables, Salmonella spp. and tomatoes, Salmonella spp. and melons, and pathogenic Escherichia coli and fresh pods, legumes or grains. ...

Although federal regulations require scientists to consider non-animal research methods fully in their proposals, there has been little training on the

Vegans can improve their omega-3 levels by taking non-animal formsof DHA. Also, browse our large selection of articles and products available at VitaNet®, LLC

The implementation of the SkinEthic™ HCE method, as a validated reference method in the OECD test guidelines TG 492 is already considered.. The draft of TG492 on Reconstructed human Cornea-like Epithelium test method for eye hazard potential is currently under review by the states members of OECD with an approval expected by summer 2017. Our corneal model and corresponding protocols (for liquids and for solids) are designed to comply with regulatory purposes to classify and label chemicals regarding in vitro ocular irritation assessment. ...

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REACh is the regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals. It entered into force on June 1, 2007. It streamlines and improves the former legislative framework on chemicals of the European Union (EU). The main aims of REACh are to ensure a high level of protection of human health and the environment from the risks that can be posed by chemicals, the promotion of alternative test methods, the free circulation of substances on the internal market and the enhancement of competitiveness and innovation. REACh makes industry responsible for assessing and managing the risks posed by chemicals and providing appropriate safety information to their users. In parallel, the European Union can take additional measures on highly dangerous substances, where there is a need for complementing action at EU level.4 As a result of REACh, the production and use of chemicals is regulated. Substances that are produced and/or used in amounts of more than 1000 kg/year must be ...

Formaldehyde Emissions Testing - GA 6000 uses EN717-2 gas analysis method that is approved by CARB as an Alternative test method.

This issue of ALTEX includes a Food for thought article from Joanne Zurlo, two t4 workshop reports, an article about an alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes, and much more.

Cellular metabolism is essential to sustain life and underlies a vast number of mechanisms of pathogenesis. Among thousands of small-molecule metabolites, we are particularly interested in key intermediary metabolites that are shared by metabolic reactions for building cellular blocks and chemical modifications for regulatory purposes. These metabolites include S-adenosylmethionine (SAM) and acetyl-CoA, and they are kinetically stable but thermodynamically activated. We found that cellular SAM is substantially consumed by methylation of phospholipids and the histones. This bulk turnover of SAM can influences cell growth and the redox environment, as it subsequently fuels the synthesis of cysteine and glutathione. We also discovered that a unique carboxyl methylation of the major phosphatase PP2A can act as a cellular gauge of SAM. Metabolic processes that alter cellular SAM levels can thus signal SAM-sensitive PP2A methylation for phosphoproteomic control. We demonstrated a PP2A-governed ...

Genentech, Inc. (NYSE:DNA) and Biogen Idec (Nasdaq:BIIB) today announced that a global Phase III study of Rituxan(R) (rituximab) in combination with fludarabine and cyclophosphamide chemotherapy met its primary endpoint of improving progression-free survival (PFS), as assessed by investigators, in patients with previously treated CD20-positive chronic lymphocytic leukemia (CLL) compared to chemotherapy alone. There were no new or unexpected safety signals reported in the study. An independent review of the primary endpoint is being conducted for U.S. regulatory purposes. Data from the study, REACH, will be submitted for presentation at a future medical meeting. Earlier this year, another European Phase III study, CLL-8, showed a similar treatment combination improved PFS in patients with CLL who had not previously received treatment. REACH, the largest relapsed CLL trial ever conducted, is the first Phase III study of this treatment combination to show an improvement in progression-free ...

A Proposed Definition of Microbiota Transplantation for Regulatory Purposes, Gut Microbes, Mar. 20, 2017 (with others).. Stopping Deceptive Health Claims: The Need for a Private Right of Action Under Federal Law, 42 American Journal of Law & Medicine 53 (2016) (with Jack Schwartz). [Full Text]. The Importance of Including the Deans, Journal of Law, 41 Medicine & Ethics 81 (Supp. 2016).. Access to Essential Medicines in African Countries: An Introduction, 31 Maryland Journal of International Law 1 (2016) (with Peter Danchin). [Full Text]. Increasing Access to Dental and Medical Care by Allowing Greater Flexibility in Scope of Practice, 105 American Journal of Public Health 1755 (2015) (with Richard J. Manski and Virginia Rowthorn).. Laying the Foundation for an Interprofessional, Comparative Health Law Clinic, 42 Journal of Law, Medicine & Ethics 392 (2014) (with Chikosa Banda and Kassim Amuli). [Abstract]. Probiotics: Achieving a Better Regulatory Fit, 69 Food & Drug Law Journal 237 (2014) (with ...

Proceeding/Conference:Preprints of the 4th Workshop on Harmonisation within Atmospheric Dispersion Modelling for Regulatory Purposes, Belgium, May 1996 ...

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The Contrary Intention Report is used for reporting of contrary expiration quantities for Saturday expiring options. This information is required by options exchanges for regulatory purposes. Contrary Intention Report ...

Density and relative density measurements of light hydrocarbons, including LPG, are used for transportation, storage and regulatory purposes. The measurement is made by floating a thermohydrometer in a sample that has been introduced into a pressure cylin

ABRSM Alternative Aural Tests For Deaf And Hearing Impaired: Grade 1-8 Alternatives to aural tests for deaf and hearing-impaired Piano candidates. Alternative tests for other instruments, for blind and par

With the recent approval of the human Cell Line Activation Test (h-CLAT) for skin sensitization (allergy), toxicologists now have a battery of methods that allows them to test for sensitization without using animals. Testing a chemical substance for skin irritation or corrosion is pretty straight-forward: the substance is applied to a skin sample (there are…

Your doctor may be able to rule out prostate cancer without a biopsy. Learn about alternative tests that can be used to determine your risk.

I think that the subjectee (i dont know if thats a word), even if they have no rights, should still be able to consent to this, this should be given as an option or as an alternative, if presented at all. For example, if someone is about to get the electric chair, they can opt for an alternative test subject. Put on max security, no contact by outside source, and the only contact they get is the docs that work on them. But i can only assume this would turn out to be a pointlessly small number of people ...

Save 34% Universal - Animal Test 21 Pack Animal Test The Hypertrophic Test Stack Anabolic Response Amplifier Arachidonic Acid Divanillyl Cissus Trans Resveratrol Hesperetin Yohimbe What Animal Test Is Gear up. . Every training session, every meal, is another test to pass. Your approach is dead serious. Nothing is left to chance. You know the importance of testosterone. More test = more size & strength. It is that simple. That is why you gear up with Animal Test. Animal Test keeps it simple, breaking down the muscle-building process to its bare essence & amplifying the anabolic response. Animal Test is legal hypertrophic, pro-testosterone supplementation at its best. Animal Test helps enhance both testosterone output and utilization. Animal Test cuts to the core of the muscle-building process, modifying and enhancing the anabolic response. In other words, Test is money in the bank.* Who We Are In 1983 Animal was founded with the birth of Animal Pak, the venerable training pack that started it all. Born

Save 34% Universal - Animal Test 21 Pack Animal Test The Hypertrophic Test Stack Anabolic Response Amplifier Arachidonic Acid Divanillyl Cissus Trans Resveratrol Hesperetin Yohimbe What Animal Test Is Gear up. . Every training session, every meal, is another test to pass. Your approach is dead serious. Nothing is left to chance. You know the importance of testosterone. More test = more size & strength. It is that simple. That is why you gear up with Animal Test. Animal Test keeps it simple, breaking down the muscle-building process to its bare essence & amplifying the anabolic response. Animal Test is legal hypertrophic, pro-testosterone supplementation at its best. Animal Test helps enhance both testosterone output and utilization. Animal Test cuts to the core of the muscle-building process, modifying and enhancing the anabolic response. In other words, Test is money in the bank.* Who We Are In 1983 Animal was founded with the birth of Animal Pak, the venerable training pack that started it all. Born

Ocular irritation testing is a common requirement for the classification, labelling and packaging of chemicals (substances and mixtures). The in vivo Draize rabbit eye test (OECD Test Guideline 405) is considered to be the regulatory reference method for the classification of chemicals according to …

February 22, 2016 GAITHERSBURG, MD - February 22, 2016 - The Institute for In Vitro Sciences, Inc. (IIVS) has received a grant from the Research Institute for Fragrance Materials (RIFM) to develop non-animal test methods for the evaluation of fragrance materials for potential respiratory irritation and sensitization.. The grant was secured in collaboration with Liverpool John Moores University and the Physicians Committee for Responsible Medicine. The proposal, The use of a novel non-animal platform to characterize respiratory effects of fragrance materials combines computational approaches as well as in chemico techniques, and includes a testing plan in harmony with concepts for the OECD Adverse Outcome Pathway program.. The ability to evaluate the effect of fragrance materials on the respiratory system is significant for many industries. This project is expected to deliver far-reaching benefits to the scientific community for evaluating respiratory irritation and sensitization, said Dr. ...

Task force member, Microbial risk analysis in food safety, Council for Agricultural Science and Technology (2004-2005). Expert reviewer, Control of Listeria monocytogenes in foods, International Life Science Institute (2003-2004). Panel chair, Food Science and Post Harvest Technology, United States-Israel Binational Agricultural Research and Development Fund (2002-2005). Food and Water Safety Committee member, U.S. Department of Defense (2002-2005). Working Group member, Joint Institute for Food Safety and Applied Nutrition (2001-2005); Organizing committee member, Central Sciences Laboratory/JIFSAN Annual Symposium Series (2001-2005); Steering committee member, International Risk Assessment Training, International Life Science Institute (2001-2003). Senior Science Council member, Food and Drug Administration (2001-2005). Lead Scientist Council member, Center for Food Safety and Applied Nutrition (2001-2005). Science Council member, FDA Center for Food Safety and Applied Nutrition ...

27th Meeting, 2009: Dissecting Genome Structure, Genetic Traits, and the Basis for Complex Diseases. 26th Meeting, October 6, 2008: Inflammation in Cancer. 25th Meeting, October 29, 2007: Current and Future Issues in Environmental Toxicology. 24th Meeting, October 26, 2006: Oxidative Stress and Damage. 23rd Meeting, October 26, 2005: Genetics of Aging. 22nd Meeting, November 10, 2004: DNA Methylation and its Toxicological Consequences. 21st Meeting, 2003:. 20th Meeting, October 22, 2002: The Science of Bioterrorism. 19th Meeting, November 6, 2001: Toxicogenomics. Annual Fall Meetings - 1991 through 2000. 18th Meeting, October 25, 2000: Genetically Modified Food: Benefits and Risks to Human and Environmental Health. 17th Meeting, October 25, 1999: Current Trends in Genetic Toxicology. 16th Meeting, October 2, 1998: Genetic Susceptibilities Affecting the Response of Children to Toxicants. 15th Meeting, 1997:. 14th Meeting, October 11, 1996: The Use of Transgenic Mice in Toxicology. 13th Meeting, ...

Animal-free testing methods are being increasingly explored and implemented as an alternative to animal models, in efforts to provide a more accurate prediction of a drug candidates efficacy and safety. InSphero recently hosted a virtual roundtable discussion on the topic of animal-free testing. |i|Technology Networks|/i| had the pleasure of speaking with Armin Wolf, chief scientific officer at InSphero, to learn more about the topics discussed.

PETA Science Consortium International organises workshops on various topics, including the development of non-animal methods to examine the subchronic inhalation toxicity of nanomaterials, alternative methods for the identification of acute systemic toxicity, in vitro approaches for medical device pyrogen testing, and the development of animal-free recombinant antibodies.. In addition, the Science Consortium organises webinars focused on the use of alternative approaches to meet REACH requirements, inhalation toxicity testing, recombinant antibodies, and the use of new approach methodologies in risk assessment.. The Science Consortium also funds hands-on training on the use of and interpretation of data from non-animal tests.. ...

Genomic data from foodborne pathogens, by itself and in combination with other information, is a robust resource that can help public health officials identify and understand the source of foodborne foodborne illness outbreaks.

The Animal Alternatives in Environmental Science Advisory Group was formed in 2008 to facilitate scientific discussion of relevant aspects of alternative tests in environmental science as a means to reduce, refine, or replace standard toxicity tests with vertebrates around the globe. Over the past 4 years, more than 400 candidate abstracts expressing interest to join regular sessions have been considered at SETAC North America and SETAC Europe regional meetings. During this same time frame, the burgeoning interest in systems biology, the maturation of genomic and other tools and the concepts of adverse outcome pathways have also become part of the discussion on alternatives. Past activities of the Animal Alternatives in Environmental Science Advisory Group have included sponsoring workshops on in vitro methods in environmental toxicology, providing a sounding board for SETAC leadership on use of animals in research and the commitment of SETAC to animal welfare and leading forums such as this ...

In 1957 Charles Hume and William Russell introduced the concept of the three Rs in their book Principles of Humane Experimental Technique. These techniques to reduce animals used in tests and their suffering include: replacement (eliminate an animal test altogether), reduction (fewer animals used in test by using statistical analysis) and refinement (making tests less painful).[4] In 1991 the European Center for the Validation of Alternative Methods (ECVAM) was established to promote the scientific and regulatory acceptance of alternative methods which are important to the biosciences and which reduce, refine or replace the use of laboratory animals.[5] Once the ECVAMs Scientific Advisory Committee approves a test it must be used under the Animal Protection Act, which does not allow the use of animals when an alternative exists. In 2012, British Union for the Abolition of Vivisection joined forces with New England Anti-Vivisection Society and the European Coalition to End Animal Experiments ...

A €50 million European public-private partnership (PPP) has paved the way to a new era of assessing chemical safety without using animals. SEURAT-1 -Towards the Replacement of In VivoRepeated Dose Systemic Toxicity Testing -showcases its achievements during a final symposium on 4 December 2015.. The EUs FP7 and Cosmetics Europe each contributed €25 million to the largest PPP initiative in the field. The project has successfully built on collective knowledge, taking advantage of the cross-disciplinary expertise of regulators and scientists from over 70 universities, research institutes and companies. Together they have defined a common research strategy and made a decisive step to overcome fragmentation in the research community. SEURAT-1s work not only meets the specific needs of the cosmetics industry but also contributes to a global safety assessment solution forany chemical.. SEURAT-1 marks a significant strategic milestone in the journey towards a future of animal-free testing; it ...

Overall, the complexity of organs and events involved in the reproductive cycle simply prevents to find the alternative test for reproductive toxicology [13]. However, the reproductive cycle can be broken up in building blocks (components and/or pathways), so to set up a comprehensive battery of tests, each of them addressing one component. This led to a project structure with three major research areas dealing with cell/tissue specific approaches and with the ambition of providing an array of test targeting the essential steps of reproductive cycle: fertility; implantation; prenatal development. Whereas the developmental toxicity tests were closer to optimization phase, the test batteries dealing with male and female fertility and implantation were more complex to develop encompassing a number of cells/tissues (sperm, Leydig cells, oocytes, ovary granulosa cells, trophoblasts, etc.) and of targeted parameters (DNA integrity, steroidogenesis, etc.). Noticeably, during ReProTect some new ...

The EU Cosmetics Directive aims to phase out animal testing. It established a prohibition on the testing of finished cosmetic products (since 2004) and cosmetic ingredients (since 2009) on animals and a prohibition on the marketing in the EU of finished cosmetic products and ingredients included in cosmetic products which were tested on animals outside the EU. The latter marketing ban applies since 2009 for all human health effects with the exceptions of repeated-dose toxicity, reproductive toxicity and toxicokinetics. For these health effects, the ban will apply step by step but with a maximum cut-off date of 10 years after the entry into force of the directive (11 March 2013), irrespective of the availability of alternative non-animal tests.(1). 1. Does the Commission agree that a case-by-case derogation would mean a delay in the complete marketing ban on animal testing, and that with this third delay the Commission will lose credibility with the citizens of Europe?. 2. Given that 80-90 % of ...

U-M Life Sciences Institute Saltiel Life Sciences Symposium Game Changers: Technologies that are Rewriting the Future of the Life ...

Michigan House Speaker Andy Dillon, right, visited the Life Sciences Institute on Friday to meet with stem cell researchers from across the U-M campus. Pictured from left are: Mark Burton of Dillons staff; Sean Morrison, director of the Center for Stem Cell Biology; Jack Mosher, assistant research scientist at the Life Sciences Institute; Kirk Profit, director of Governmental Consultant Services Inc.; Marty Fischoff, managing director of the A. Alfred Taubman Medical Research Institute; Cynthia Wilbanks, vice president for government relations; Liz Barry, managing director of the Life Sciences Institute; Gary Smith and Sue OShea, co-directors of the Consortium for Stem Cell Therapies; Dr. Eva Feldman, director of the A. Alfred Taubman Medical Research. (Photo by Jennifer Farina, Life Sciences Institute) ...

Scientists at the University of Michigan Life Sciences Institute have discovered how one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities - from fighting insects to killing fungus.. Hapalindoles compose a large class of structurally diverse natural products made by cyanobacteria. Their structural diversity is reflected in the widely varying activities of the products, including antibacterial, antifungal and insecticidal activities. Until recently, relatively little was known about how nature manages to develop these diverse organic compounds from the same starting material. Now, researchers in the lab of David Sherman, Ph.D., at the LSI have shown that the various structural arrangements in this class all arise from a central starting point and all begin their transformations through a novel class of enzymes.. By solving the structure of an enzyme called a Stig (for Stigonemataceae) cyclase, the U-M researchers were able to ...

For the AHLA Life Sciences Institute, Epstein Becker Green attorney Bradley M. Thompson presented an update on combination products. ...

Anahad OConnor A prominent medical journal on Monday published a scathing attack on global health advice to eat less sugar. Warnings to cut sugar, the study argued, are based on weak evidence and cannot be trusted.. But the review, published in The Annals of Internal Medicine, quickly elicited sharp criticism from public health experts because the authors have ties to the food and sugar industries.. The review was paid for by the International Life Sciences Institute, a scientific group that is based in Washington, D.C., and is funded by multinational food and agrochemical companies including Coca-Cola, General Mills, Hersheys, Kelloggs, Kraft Foods and Monsanto. One of the authors is a member of the scientific advisory board of Tate & Lyle, one of the worlds largest suppliers of high-fructose corn syrup.. Critics say the medical journal review is the latest in a series of efforts by the food industry to shape global nutrition advice by supporting prominent academics who question the role of ...

This thesis is an historical analysis of the culture of science and its use of animals in experiments by the British military and in medical scientific research, and its regulation by law, during the period 1947 to 1965. The overall aim of this thesis is to demonstrate the gendered nature of scientific experimentation on animals in mid-twentieth century Britain. To do this, it addresses two aspects of animal experimentation; firstly, exploring how scientific research forms power-knowledge relations through the use of nonhuman animals. Secondly, this thesis analyses the intersection of animal use in science with that of the broader socio-cultural context, asking was science in mid-twentieth century Britain gendered? As a consequence, it explores the effects of this knowledge production upon animals and women. My findings are twofold: that the construction of scientific knowledge through the use of nonhuman animals was one that created subject-object binaries, and this had powerful and detrimental ...

Alan Boobis and Angelo Moretto have ties to the International Life Sciences Institute (ILSI). ILSI Europe receives a majority of its operating and research funding from private companies, including glyphosate producers Dow and Monsanto. ILSIs Health and Environmental Sciences Institute (HESI) is primarily funded by private companies, including glyphosate producers Dow, Monsanto and Syngenta.. Most scientists involved in the glyphosate assessment by the European Food Safety Authority (EFSA), which also contradicted the WHO cancer warning, refused to be named.. Greenpeace EU food policy director Franziska Achterberg said: The agencies contradicting the WHO cancer warning seem to either rely on officials who prefer not to be named, or lack a watertight policy to protect their impartiality. Any decision affecting millions of people should be based on fully transparent and independent science that isnt tied to corporate interests. It would be irresponsible to ignore the warnings on glyphosate and ...

Zebrafish models for human acute organophosphorus poisoning. Natalia Garcia-Reyero. Workshop on Alternative Approaches for Identifying Acute Systemic Toxicity: Moving From Research to Regulatory Testing. Bethesda, MD, USA, September 24-25, 2015. Scientific meeting agenda ...

And there is no wane in sight. First, the extra-territorial imitators have been cast into disarray by the shrewd strategic move of the Prosecco producers to take their future back into their own hands. The Prosecco DOC was first awarded in 1969 and was restricted to wines produced in the Conegliano-Valdiobbadene region. Growers felt that the brand was under attack by imitators using just the grape variety and moved to isolate those competitors by changing both the rules and the venue of the game. Prosecco growers agitated for, and gained regulatory acceptance of: (i) extension of the Prosecco DOC to cover all of Friuli-Venezia-Giulia and approximately two-thirds of Veneto; (ii) promotion of the original Prosecco DOC to DOCG status; (iii) changing the name of the source grape from Prosecco to Glera; and (iv) restricting the use of the name Prosecco only to Glera sparkling wines produced within the delimited zones. The growers felt that these actions would serve to protect their territory, the ...

Find local Science Research Health Scientific groups in Brussels and meet people who share your interests. Join a group and attend online or in person events.

Bio-Matrix Scientific Group, Inc. Due Diligence Report provides a complete overview of the companys affairs. All available data is presented in a comprehensive

United Scientific Group (USG) cordially invites all the participants from all over the world to attend International Conference on Infectious Diseases during November 5-7, 2018 in Berlin, Germany (Infectious Diseases-2018). ...

According to Stratistics MRC, the Global In Vitro Toxicology Testing Market is accounted for $12.30 billion in 2015 and is expected to reach $32.45 billion...

The U.S. Food and Drug Administration has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and tobacco heating products (THPs). There is a desire by the industry, regulators and animal protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment. When assessing respiratory effects in vitro, reliable exposure systems that deliver aerosols to cellular/tissue cultures (such as human reconstructed airways or lung slices) at the air-liquid interface are needed. Using nicotine dosimetry, we report the... Acute Respiratory Toxicity , Chronic Respiratory Toxicity , Goblet Cell Hyperplasia , Pulmonary Models , Respiratory Toxicology , Tobacco , Devin Sheehan , e-cigarette , Erin Hill , Holger Behrsing ...

Committed to developing alternative testing methods; JRF Global offers a customized battery of in vitro tests for the chemical and cosmetic industry for new ingredients and finished products.

ECHA is working closely with certain sectors of the chemical industry to develop guidance on how to identify substances for regulatory purposes. Where relevant, ECHA will do this within the framework of the OECD.. Under each sector link, you will find sector-specific substance identification guidance as it becomes available. This guidance is not official ECHA guidance and does not replace the ECHA guidance for identification and naming of substances under REACH and CLP. Instead, it should be seen as complementary to the official guidance by expanding further on the general concepts. This helps to ensure a consistent approach to identifying substances within industry sectors.. The sector-specific guidance, together with the official ECHA guidance, can help you to identify your substance correctly and achieve compliance with REACH in respect of substance identification.. ...

Introduction. A Quantitative Structure Activity Relationship (QSAR) model was used to predict the Ready Biodegradability of the test item Tetrasodium 1,3,6,8-pyrenetetrasulfonate. This QSAR model has been designed to be used for regulatory purposes and based on the QSAR results, this report predicts the consensus endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the OECD Guideline for Testing of Chemicals No. 301: Ready Biodegradability. Methods. The purpose of the in silico study was to predict the Ready Biodegradability of the test item Tetrasodium 1,3,6,8-pyrenetetrasulfonate. This prediction was performed using the following QSAR models: · EPI Suite - BIOWIN · Battery of Leadscope, SciQSAR and CASE Ultra models integrated into the Danish QSAR Database Results. Based on multiple QSAR models applied, Tetrasodium 1,3,6,8-pyrenetetrasulfonate was predicted as non-readily biodegradable. The final Ready Biodegradability was ...

The firm TOSOH Bioscience Inc., sent an URGENT: MEDICAL DEVICE RECALL letter dated March 23, 2018 to affected customers. The letter described the product, problem and action to be taken. The customers were instructed to do the following: *Based on our revised labeling, the assays identified in Table 1 should not be used for patients who are being treated with Asfotase Alfa. For patients that are being treated with Asfotase Alfa, use an alternative test method that does not utilize alkaline phosphatase technology. Inform all medical professionals that assays utilizing alkaline phosphatase-based technologies must not be used for patients receiving Asfotase Alfa treatment. Continue to use the assays listed in Table 1 for any patients who are not receiving Asfotase Alfa treatment. Complete and return the attached Acknowledgement Form to Tosoh Bioscience, Inc., within 15-days of receiving this notification via Fax: 1-650-636-8651, Email: [email protected] or Regular mail: 3600 Gantz ...

The Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) is an Australian legislative instrument produced by the Therapeutic Goods Administration (TGA). Before 2010, it was known as the Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP). The SUSMP classifies drugs and poisons into different Schedules signifying the degree of control recommended to be exercised over their availability to the public. The Schedules are referred to under State and Territory legislation for regulatory purposes. Although each State and Territory has its own laws, the vast majority of medicines and poisons are classified according to the SUSMP to achieve uniform national regulation. The current version, the SUSMP 16, is contained in the Poisons Standard February 2017. Medication that is available on the shelf at supermarkets, convenience stores, and pharmacies. These are considered to be low risk drugs, and have directions of use clearly labelled on both the packaging, and the receptacle. ...

Participation in FILL and USIDNET, as with any research, is completely voluntary. You have the right to stop your child from participating at any time. You can choose not to have your child participate now or even withdraw your childs participation in the future, and it will not affect your childs medical treatment or access to care in any way and will involve no penalty or loss of benefits to which your child is otherwise entitled.. The study doctor, local institution, or sponsor may remove your child/legal dependents information from the Registry at any time without your consent and may also remove the child/legal dependents information from the Registry at any time if they indicate that they no longer wish to participate in the study.. You will be asked to sign a separate form to authorize the use and disclosure of your childs medical information for research or regulatory purposes related to this study. You have the right, however, to cancel this authorization to use and disclose your ...

I cited the lysine requirement for children 2 to 5 years old (based on an old report apparently), which is what I saw multiple times in a few studies as the one for high biological value protein , but for adults the requirements are more modest (actually 45mg/g of protein, rice is still lower than this unfortunately) like the one you cited and depending on which report or study (the one of 1985, 1991 or 2007 by FAO) the source is being based the values may vary, and even the same report might recommend the intake of a different age class for all ages, excepting infants, for regulatory purposes (requirements of children from 6m to 3y old for all ages, recently). Different ages have different necessities making the claim for a complete protein based also on the stage of life, which explains the different requirements we both cited.. ...

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Restriction Description: The information obtained during the conduct of this trial is considered confidential and can be used by Novo Nordisk for regulatory purposes and for the general development of the trial product. The information obtained during this trial may be made available to other physicians who are conducting other clinical trials with the trial product, if deemed necessary by Novo Nordisk ...

Involvement of subcellular structures in miRNA-mediated gene regulatory processes is an underexplored research domain. Although the importance of endosomal trafficking for miRNA-mediated repression processes has been documented previously, the molecular details have never been investigated. In recent times, findings related to secretion of small RNAs via exosomes (7, 31) for intercellular cross talk or other regulatory purposes justify the possible link between the endocytic pathway and miRNA-mediated gene silencing. In this paper, we report that LE/MVB targeting is crucial for degradation of miRNA-targeted mRNAs. Our findings highlight how miRNA-mediated mRNA repression and the endocytic pathway interact. The work described here also reveals how the mRNA degradation process is compartmentalized in mammalian cells.. Cytoplasm of eukaryotic cells is subdivided into membrane-bound compartments called organelles. Compartmentalization of cellular processes to specific subcellular locales is a ...

Many EMRs read like Madlibs(for those of you old enough to remember what they are), because they are in fact cut-and-pasted snippets of data from other parts of the EMR, put in place to fulfill some billing documentation requirement or some regulatory imperative. Free text annotation is often discouraged, and frequently impossible to juxtapose next to the appropriate snippet of information in the chart. Some systems make it very difficult to generate any kind of free form documentation, and consequently critical events in the course of a hospitalization are never documented. In most or all hospitals, practitioners have developed a shadow chart that incorporates all of the critical information that practitioners need to know to care for a patient. The existence of these shadow charts has been driven by the hijacking of the medical record for billing and regulatory purposes. The creation of these charts represents additional effort for everyone who directly participates in the care of patients. ...

Study Finds No Advantage to Newer Tests for Cervical Cancer. Wang, Linda // JNCI: Journal of the National Cancer Institute;5/7/2003, Vol. 95 Issue 9, p644 Cites a study by researchers from the French Society of Clinical Cytology Study Group, which suggests that alternative tests do not outperform conventional testing and should not replace the Pap smear for cervical cancer screening. Comparison of the sensitivity, specificity, and reliability of... ...

FALSE negative tests can definitely be a BIG problem…and it can happen with several diseases, besides Lyme!! Rheumatoid Arthritis to syphilis…and many others disease processes in between. (False positives can also skew things for patients!). Thats why its so important to find a doctor who doesnt just TREAT TEST RESULTS! Yet this gets much harder to do, especially as technology advances! More and more doctors rely SOLELY on our tests and lab results…often not even repeating them if questioned by the patient, or not researching a possible alternative test…or a diagnosis based on other grounds or observed criteria! And they rely so much less now on taking good patient HISTORIES…and sadly even LESS on good PHYSICAL exam assessments!!. Weve all likely run into this! Where later we find out our histories are so incomplete…or just plain wrong! And also where we could honestly have a tennis shoe growing out of our bodies and the doctor wouldnt even KNOW…because he or she DIDNT EVEN ...

A blood test checking your level of FSH (follicle-stimulating hormone) is the usual test to diagnose potential ovarian failure. Your GP may also arrange for alternative tests to confirm the diagnosis and/or refer you to a gynaecologist for specialist advice.. Women whose ovarian function is reduced from an earlier age are at a higher risk of osteoporosis. Bone scans are recommended for anyone diagnosed with premature ovarian failure. Women can be more susceptible to fractures, and a calcium rich diet with calcium supplements is recommended.. The most significant effect of premature ovarian failure, however, is the possibility of infertility. This can obviously be incredibly upsetting for the patient and can lead to long term psychological consequences.. Coming to terms with infertility can be a difficult process, and it is very important that women seek appropriate support and counselling. GPs should be able to suggest local support groups or networks with which women can talk to about their ...

List of 6 disease causes of Minor eye irritation, patient stories, diagnostic guides, drug side effect causes. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Minor eye irritation.

This webinar will provide an overview of the scientific and welfare benefits of moving to the use of animal-free antibodies and affinity reagents and will highlight the recent Recommendation on Non-Animal-Derived Antibodies from the EU Reference Laboratory for alternatives to animal testing (EURL ECVAM). The target audience is all researchers who use antibodies in their

Hydrogen Peroxide Cell Test Method: photometric 2.0 - 20.0 mg/l H₂O₂ Spectroquant® - Find MSDS or SDS, a COA, data sheets and more information.

Taxpayer-funded animal experimentation is un-American, and we have the data to prove it.. Opinion surveys in recent years show Americans growing opposition to animal experimentation, with the most recent Pew poll reporting that a majority of Americans now object to the use of animals in scientific research.. Now, as reported by Red Alert Politics, a new national poll commissioned by the White Coat Waste Project and conducted by research firm Lincoln Park Strategies shows that most Americans-Republicans and Democrats alike-are sick of footing the $12-billion-plus bill for these wasteful and secretive experiments on dogs, cats, monkeys and other animals.. The poll of 1,109 U.S. voters found that a majority (about 6 in 10) want to see funding cut and transparency increased for taxpayer-funded animal experiments. According to the survey (also visualized in the infographic below):. ...