The presence of angiotensinogen messenger RNA (mRNA) was assessed in total RNA extracted from hepatoma, glioma, neuroblastoma, and glioma-neuroblastoma hybrid cell lines. Total RNA from 1 X 10(7) cells was extracted, transferred to a membrane, and hybridized with a 32P-labeled, full-length (1650-base pair) rat angiotensinogen complementary DNA (cDNA). Angiotensinogen RNA sequences could be definitively detected only in hepatoma cells. Steroids were used in an attempt to increase the angiotensinogen mRNA level. Dexamethasone (2 X 10(-6) M) or 17 beta-estradiol (1 X 10(-7) M) was added to the cultures 18 to 24 hours prior to harvest. Dexamethasone treatment of the hepatoma cells resulted in a large increase in angiotensinogen mRNA, whereas estradiol had no effect. Steroids failed to induce detectable levels of angiotensinogen mRNA in total RNA from the other cell lines. That the RNA was intact was ensured by hybridizing duplicate Northern blots to a 32P-labeled actin cDNA. Actin mRNA sequences ...
TY - JOUR. T1 - Glucocorticoid and thyroid hormone regulation of angiotensinogen gene expression in a pancreatic islet cell line.. AU - Brasier, A. R.. AU - Philippe, J.. AU - Campbell, D. J.. AU - Habener, J. F.. PY - 1986/12/1. Y1 - 1986/12/1. N2 - The renin-angiotensin system is an important regulator of blood pressure and volume homeostasis in mammals. Angiotensinogen, a precursor of the octapeptide angiotensin II and an effector of the renin-angiotensin system, is synthesized in numerous rat tissues. Angiotensinogen is expressed in an islet cell line (RIN 1056A) derived from a rat pancreatic tumor. Angiotensinogen mRNA detected by Northern analysis is abundant in the cell line and is approximately 200 bases longer than the mRNA isolated from rat liver, due to both a longer poly(A) tract and the use of a second polyadenylation site. Dexamethasone is a potent inducer of angiotensinogen mRNA, producing a progressive accumulation from 3 to 96 hr in culture (9-fold above control levels). The ...
Angiotensinogen messenger RNA (mRNA) levels were measured in the brain (hypothalamus, lower brain stem, cerebellum), liver, kidneys, and adrenal glands of rats made hypertensive by ligation of the aorta between the renal arteries. We also measured renin mRNA in the kidneys of these renal hypertensive rats. The early phase of hypertension (day 6) was associated with significant increases in plasma renin activity and levels of circulating angiotensin II. The circulating renin-angiotensin system was not activated in the later phase of hypertension (day 24). Angiotensinogen mRNA levels were elevated in the lower brain stem of hypertensive rats at both stages of hypertension. In contrast, angiotensinogen mRNA levels in the hypothalamus were increased only at day 6 after aortic ligation. Decreased levels of angiotensinogen mRNA were observed in the cerebellum in both the early and later phases of the hypertension. Angiotensinogen mRNA levels in the adrenal gland below the ligature fell in the early ...
TY - JOUR. T1 - Hyperglycemia modulates angiotensinogen gene expression. AU - Gabriely, Ilan. AU - Yang, Xiao Man. AU - Cases, Jane A.. AU - Ma, Xiao Hui. AU - Rossetti, Luciano. AU - Barzilai, Nir. PY - 2001/10/2. Y1 - 2001/10/2. N2 - Elevated plasma angiotensinogen (AGT) levels have been demonstrated in insulin-resistant states such as obesity and type 2 diabetes mellitus (DM2), conditions that are directly correlated to hypertension. We examined whether hyperinsulinemia or hyperglycemia may modulate fat and liver AGT gene expression and whether obesity and insulin resistance are associated with abnormal AGT regulation. In addition, because the hexosamine biosynthetic pathway is considered to function as a biochemical sensor of intracellular nutrient availability, we hypothesized that activation of this pathway would acutely mediate in vivo the induction of AGT gene expression in fat and liver. We studied chronically catheterized lean (∼300 g) and obese (∼450 g) Sprague-Dawley rats in four ...
Gastric sodium loading results in an increase in the portal venous concentration of vasoactive intestinal peptide (VIP) and down-regulation of both the intrahepatic and circulating renin-angiotensin systems. In the present study we sought to determine whether an increase in the concentration of VIP in the portal circulation might act to down-regulate the intrahepatic and/or circulating renin-angiotensin systems. Male Sprague-Dawley rats were infused intraportally with haemaccel vehicle or VIP in haemaccel for 60 min. Livers were harvested and blood was sampled. Angiotensin-converting enzyme (ACE) activity and angiotensinogen, angiotensin I, angiotensin II and renin concentrations were measured. VIP infusion decreased hepatic ACE activity (P , 0.05), the hepatic angiotensinogen concentration (P , 0.001) and the hepatic angiotensin I concentration (P , 0.05). The plasma angiotensinogen concentration and serum ACE activity were also decreased by intraportal VIP infusion (P , 0.05 for each). Plasma ...
Buy our Recombinant Human Angiotensinogen protein. Ab191974 is a full length protein produced in HEK 293 cells and has been validated in SDS-PAGE, HPLC. Abcam…
The studies in this thesis describe the development of a microarray based minisequencing system and its application to highly parallel genotyping of single nucleotide polymorphisms. The technical developments included identification of a three-dimensional microarray surface coating with high binding capacity for oligonucleotides modified with amino groups as the most optimal one for the system. The system was also established for multiplexed, reproducible quantitative analysis of SNP alleles both on the level of DNA and RNA. The sensitivity of the system to distinguish SNP alleles present as a minority in a mixed sample was found to be 1-6%.. The microarray based minisequencing system was applied in a pharmacogenetic study on antihypertensive drug response. A panel of 74 SNPs located in candidate genes related to blood pressure regulation were genotyped in DNA samples from hypertensive patients that had been treated with the antihypertensive drugs irbesartan or atenolol. Multiple regression ...
Human angiotensinogen has been purified 390-fold from serum by a rapid high-yielding procedure that involved chromatography on Blue Sepharose, phenyl-Sepharose, hydroxyapatite and immobilized 5-hydroxytryptamine (5-HT). Angiotensinogen was specifically bound to immobilized 5-HT, which effected a partial resolution into multiple forms, which were also evident when analysed by SDS/polyacrylamide-gel electrophoresis (Mr 59,400, 60,600, 62,600 and 63,800). This heterogeneity was confirmed by resolution into six main bands on isoelectric focusing, ranging from pI 4.40 to 4.82. N-terminal analysis, digestion with human renal renin and deglycosylation studies implied that the preparation comprised several forms of angiotensinogen, varying in their degree of glycosylation. The presence of sialic acid was shown to be a major factor in determining the heterogeneity. ...
|p|Acetyl Angiotensinogen (1-14),porcine, (C87H125N21O21) is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH, MW= 1801.05. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiote
BACKGROUND: The relationship between circulating levels of angiotensinogen and hypertension in the epidemiologic setting has not been studied much. Recent findings related to the association between hypertension and polymorphisms of the angiotensinogen gene have generated new interest in this potential pathway to hypertension. OBJECTIVES: To examine environmental factors associated with levels of circulating angiotensinogen as determinants of hypertension in populations of African origin. METHODS: We recruited 1557 participants from communities in Nigeria (n = 611), Zimbabwe (n = 161), Jamaica (n = 476), and Maywood, Illinois, USA (n = 309). RESULTS: Mean angiotensinogen levels varied widely across groups (Nigeria 1381 ng/ml angiotensin I generated, Zimbabwe 1638 ng/ml angiotensin and I generated Jamaica 1801 ng/ml angiotensin I generated, and Maywood 2039 ng/ml angiotensin I generated). Average body mass index was highly correlated to angiotensinogen level across the population samples, ...
Abstract: Association of Angiotensin Converting Enzyme Insertion/Deletion and Angiotensinogen T235 Polymorphisms with Risk of Essential Hypertension in Egyptian Patients
The Human Angiotensinogen ELISA uses two highly specific antibodies to measure angiotensin precursor levels in a variety of samples.
Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells.
Complete information for AGT gene (Protein Coding), Angiotensinogen, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
The evolution of the understanding of the lung / alveolus in the last 30 years.. Old textbooks (circa 1970s) mostly offer hand drawings.. Since then, we have an improving understanding that has gone. from a view at the level of the microscope to the electron microscope. to the scanning electron microscope.. What is missing in the literature is giving the clinicians at bedside a. good understanding of the physics and physiology of the lung and the alveolus.. Ill give one example :. One of the major functions of the lung is an endocrine function : that of. converting Angiotensinogen to Angiotensin.. The lung is the primary place where ACE (angiotensinogen converting enzyme is. located. The kidney is the secondary place where ACE is found.. What happens to this pulmonary feature of conversion via enzymatic process in the. lung when the lung is significantly atelectatic or the lung is in serious crisis during. a pulmonary edematous event?. Angiotensin is the endogenous hormone that keeps ...
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
B6.B6CB-Agt,tm1Afu,. Homozygous mutant mice do not produce angiotensinogen in the liver, resulting in the complete loss of plasma immunoreactive angiotensin I. The systolic blood pressure of the homozygous mutant is lower than wild-type, demonstrates an indispensable role for the renin-angiotensin system in maintaining blood pressure ...
A reverse haemolytic plaque assay (RHPA) for angiotensinogen was developed in rat hepatoma H4 cells and applied to investigate the possible secretion of angiotensinogen from rat pituitary cells in primary culture. Over a 24-hour incubation period in Cunningham chambers plaques with a mean area of 2,800 +/- 430 and 590 +/- 220 microns2/plaque (SD, n = 6) formed around all viable H4 cells and 2.8 +/- 0.59% of viable pituitary cells respectively. As a positive control PRL secretion from lactotrophs was routinely checked by the RHPA and shown to form plaques with a mean area of 4,050 +/- 1,850 microns2/plaque after a 4-hour incubation. By comparing plaque size in H4 cells with angiotensinogen release in cell culture, as quantified by radioimmunoassay, the secretion rate of angiotensinogen from pituitary cells was calculated as 22 +/- 8 ng/10(6) cells/24 h. Plaque-forming cells consisted of two morphologically distinct populations; 78% being small cells (less than 6 microns diameter) containing little
We identified candidate biomarkers for the prediction of the development of severe AKI, and the prognostic potential of the most promising candidate, angiotensinogen, was verified in a larger set of patients who developed AKI after cardiac surgery. We found that uAnCR was elevated in patients who developed more severe AKI after sample collection. Elevated uAnCR was associated with worsening of AKI, independent of changes in SCr and Cleveland Clinic score, and it was also associated with several secondary outcomes. The prognostic predictive power of uAnCR was improved when only patients who were classified as AKIN stage 1 at the time of sample collection were used in the analysis, indicating that angiotensinogen could be used to predict adverse outcomes among patients who have not yet developed severe AKI as measured by serum creatinine.. Our data suggest that angiotensinogen could be used at the time of diagnosis with AKI to assess the risk of adverse outcomes. This risk assessment could lead to ...
Progressive deterioration of renal function occurs during normal aging. Previous studies on the aging kidney have demonstrated glomerular hemodynamic changes, specifically, glomerular capillary hypertension, as maladaptations that lead to proteinuria and glomerular sclerosis over time. Aging rats treated with angiotensin-converting enzyme inhibition have relatively less proteinuria and sclerosis, suggesting that age-related changes in renal function may be associated with alterations in the intrarenal renin-angiotensin system, which thus may play a major role in the pathogenesis of these maladaptations. To investigate this possibility, renal and systemic renin-angiotensin systems were examined at an early phase of the aging process (3 months) and at a later phase (12 months) in male Sprague-Dawley rats. Although plasma renin and serum angiotensin-converting enzyme concentrations did not differ significantly, the intrarenal system showed down-regulation of renin mRNA and angiotensin-converting ...
Finnish physiologist Robert Tigerstedt and his assistant Per Bergman in 1858 observed that extracts from renal cortex of rabbits had a pressor effect upon intravenous injection. They named this substance renin, In 1958 the term "angiotensin" was given to active end product of the renin-angiotensin system by two research groups on arterial pressure, one in Indiapolis (USA) bh H Page and the other in Buenos Aires(Argentina) by Eduardo Braun Menendez. Αccording their results, the Argentina group, demonstrated that renin could act on a protein present in the plasma in order to release angiotenin (which at first was named "hypertensin"). This proteic substrate was named angiotensinogen as was the actual precursor of the active principle ...
Peptides , Fluorescent Labeled Peptides , Renin FRET Substrate I; DABCYL-GABA-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS (also called Renin Substrate I in some literature) contains a renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen. Cleavage of the substrate occurs specifically at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen. This fluorogenic peptide substrate is used to continuously measure the proteolytic activity of human renin. The assay relies upon FRET-mediated, intramolecular fluorescence quenching that occurs in the intact peptide substrate. Efficient fluorescence quenching occurs as a result of favorable energetic overlap of the EDANS excited state and the DABCYL absorption, and the relatively long excited state lifetime of the EDANS fluorophore. Cleavage of the substrate by renin liberates the peptidyl-EDANS fragment from proximity with the DABCYL acceptor, restoring the fluorescence of the EDANS moiety. This leads to a
The renin-angiotensin system (RAS) is a hormone system that regulates blood pressure and extracellular volume in the body. The RAS sequentially processes angiotensinogen to angiotensin II (Ang II), a peptide hormone that is a potent vasoconstrictor. Inhibition of RAS components has been used successfully in the treatment of hypertension, heart failure and end organ damage. Renin catalyzes the first and rate-limiting step of the RAS cascade and renin is specific for angiotensinogen. Blockade of Ang II production by direct inhibition of renin has long been a therapeutic goal. Early renin inhibitors, such as enalkiren and remikiren, were effective in blood pressure lowering. However, due to poor oral bioavailability, duration of action, and high costs of synthesis, these early peptidomimetic inhibitors never progressed to pivotal clinical studies [1]. Continued clinical interest in renin has led to the recent approval of the first renin inhibitor, aliskiren (Tekturna™), a non-peptidic inhibitor ...
Исследование взаимосвязи аллельного полиморфизма генов ренин-ангиотензиновой системы, синтазы оксида азота и фолатного цикла с тяжестью ишемического инсульта
SCI de Taranan Uluslararası Dergilerdeki Makaleler:. 1. Fak AS, Küçükoğlu MS, Fak NA, Demir M, Ağır AA, Demirtaş M, Köse S, Ozdemir M. Expert panel on cost analysis of atrial fibrillation. Anadolu Kardiyol Derg. 2013 Feb;13(1):26-38. doi: 10.5152/akd.2013.004. Epub 2012 Oct 12. 2. Orun O, Nacar C, Cabadak H, Tiber PM, Doğan Y, Güneysel Ö, Fak AS, Kan B. Investigation of the association between dopamine D1 receptor gene polymorphisms and essential hypertension in a group of Turkish subjects. Clin Exp Hypertens. 2011;33(6):418-21. doi: 10.3109/10641963.2011.561898. Epub 2011 Jul 28.. 3. Cabadak H, Orun O, Nacar C, Dogan Y, Guneysel O, Fak AS, Kan B. The role of G protein β3 subunit polymorphisms C825T, C1429T, and G5177A in Turkish subjects with essential hypertension. Clin Exp Hypertens. 2011;33(3):202-8.. 4. Topal NP, Ozben B, Hancer VS, Tanrikulu AM, Diz-Kucukkaya R, Fak AS, Basaran Y, Yesildag O. Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in ...
The activation of NMDA receptors that subsequently induce cell death is believed to be primarily caused by an influx of Ca2+ into the cells, which leads to the generation of free radicals.29 In addition, it has also been reported that an enhancement of the reactive oxygen species (ROS) production occurs after excessive increases in the intracellular free Ca2+ concentration.8 The predominant form of glutamate neurotoxicity that occurs in retinal tissues has been shown to be mediated by an overstimulation of the NMDA subtype of glutamate receptors. As a result, this causes an increase of the Ca2+ influx, which is then followed by cell death.6,30,31 Furthermore, in various eye diseases, such as retinal ischemia, glaucoma, diabetic retinopathy, and age-related macular degeneration, it has been proposed that glutamate excitotoxicity and oxidative stress contribute to the retinal damage that occurs in these disorders.32-34 An increase in the retinal angiotensinogen mRNA has also been found after ...
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The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. I
Angiotensin, Renin, Angiotensin Ii, Prorenin, Bradykinin, Plasma, Renin-angiotensin System, Rats, Aldosterone, Inhibition, Blood, Tissue, Angiotensin I, Human, Patients, Blood Pressure, Pressure, Diabetes Mellitus, Endothelium, Angiotensinogen
Angiotensin is part of the renin-angiotensin-aldosterone system. It does not generally exist simply as angiotensin, but rather as angiotensinogen, befor...
Prorenin is a glycosylated aspartic protease that consists of 2?homologouslobes and is the precursor of renin. Renin activates the renin-angiotensinsystem by cleaving angiotensinogen, produced by the liver, to yield angiotensinI, which is further converted into angiotensin II by ACE, theangiotensin-converting enzyme primarily within the capillaries of the lungs. Ithas been reported that the levels of circulating prorenin (but not renin) areincreased in diabetic subjects.
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TY - JOUR. T1 - Modeling sex differences in the renin angiotensin system and the efficacy of antihypertensive therapies. AU - Leete, Jessica. AU - Gurley, Susan. AU - Layton, Anita T.. PY - 2018/4/6. Y1 - 2018/4/6. N2 - The renin angiotensin system is a major regulator of blood pressure and a target for many anti-hypertensive therapies; yet the efficacy of these treatments varies between the sexes. We use published data for systemic RAS hormones to build separate models for four groups of rats: male normotensive, male hypertensive, female normotensive, and female hypertensive rats. We found that plasma renin activity, angiotensinogen production rate, angiotensin converting enzyme activity, and neutral endopeptidase activity differ significantly among the four groups of rats. Model results indicate that angiotensin converting enzyme inhibitors and angiotensin receptor blockers induce similar percentage decreases in angiotensin I and II between groups, but substantially different absolute ...
ONLINE SUPPLEMENTAL MATERIAL Allele-Specific Expression of Angiotensinogen in Human Subcutaneous Adipose Tissue Sungmi Park 1, Ko-Ting Lu 1, Xuebo Liu 1, Tapan K. Chatterjee 2, Steven M. Rudich 3, Neal
This study provides preliminary evidence that a polymorphism in the AGT gene is independently associated with cerebral VR in white elderly persons. Homozygous carriers of the CC genotype of the rs699 SNPs have lower cerebral CO2 VR compared with the other genotypes.. To our knowledge, this is the first study to provide evidence that renin angiotensin system genes are also involved in cerebral VR. Previous evidence suggests a genetic role of this system in brain health and diseases such as stroke, depression, and cognitive impairment.26,27 This study adds evidence that this system may also be involved in VR, which is linked with aging outcomes such as stroke2 and dementia.28. CO2-dependent VR is mediated in part by the endothelium and is related to changes in nitric oxide.29,30 Changes in end-tidal CO2 are associated with fast changes in pH, which modulate the effect of nitric oxide synthase leading to changes in nitric oxide production.31 In addition, ATP-dependent K+ channel activation may ...
Abstract: The content of mRNA of renin-angiotensin system (RAS) genes in the kidney and heart of hypertensive ISIAH and normotensive WAG rats was measured by the real-time PCR. Statistically significant decrease of RAS gene mRNA was registered in the kidney of ISIAH rats, including Ren (by 45%), Аce (43%), АТ1А (34%), СОХ-2 (50%). In the myocardium АТ1А mRNA expression decreased by 28% while Ace mRNA expression increased by 80%. These results demonstrate the reduction of renal RAS basal activity in the hypertensive ISIAH rats, and this allows us to consider the ISIAH rat, as a low-renin hypertensive strain.In support of this viewpoint, in the ISIAH rats, a two-fold increase in the connective tissue sodium concentration as well as statistically significant plasma sodium increase (from 136±0,25 μmol/l in WAG to 139±0,3 μmol/l in the ISIAH rats) were found. Our conclusion backed by a tendency of the ISIAH plasma aldosterone level decrease giving in sum a classical picture of a ...
Principal Investigator:KOHZUKI Masahiro, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Circulatory organs internal medicine
The results of the present study demonstrate the presence of increased concentrations of renin and prorenin in left ventricular tissue from patients with DCM. The cardiac levels of renin and prorenin were more than fivefold the cardiac levels in the donors. In addition, the cardiac tissue-to-plasma concentration ratios for renin and prorenin (molecular mass, 48 and 54 kD, respectively) were approximately threefold the ratio for serum albumin (molecular mass, 70 kD), indicating that the levels of renin and prorenin in cardiac tissue were too high to be explained by admixture with blood or by diffusion from the blood into the interstitial fluid. In normal porcine left ventricular tissue, the renin level was also higher than can be explained by its localization in extracellular fluid.4 Purified membrane fractions prepared from porcine left ventricular tissue contained renin,4 and specific binding of renin and prorenin to rat renal and other tissue membranes has been reported.35 36 In the present ...
Elevated oxidative stress is typical in the pathogenesis of heart failure. Characteristical changes in antioxidant enzyme status, represented by glutathionperoxidase (GSH-Px) and superoxide dismutase (SOD), and changes in heat shock protein status (Hsp), denoted by Hsp25 and Hsp72, have been revealed in two different rat-models. Lipidperoxidation was quantified by the concentration of thiobarbituric acid reactive substances (TBARS). In the first model of heart failure caused by permanent activation of renin-angiotensin system in double transgenic rat, leftventricular hypertrophy accompanied by a shift of creatine kinase (CK) isoenzyme pattern to higher concentration of fetale CK-MB an -BB-isoforms was found. Higher TBARS concentrations and lower alpha-tocopherol levels caused by consumption have been measured. SOD and Hsp72 remained unchanged. The tolerance against experimental hypoxia/reoxygenation was improved by higher levels of GSH-Px and Hsp25 in both right and left ventricular tissue. In ...
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Sigma-Aldrich offers abstracts and full-text articles by [Mohammad A K Azad, Jesmin Akter, Kelly L Rogers, Roger L Nation, Tony Velkov, Jian Li].
How is Quality Control Workstation (radiographic imaging system component) abbreviated? QCW stands for Quality Control Workstation (radiographic imaging system component). QCW is defined as Quality Control Workstation (radiographic imaging system component) rarely.
TY - JOUR. T1 - Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvement of an AT(1)-Receptor Mediated Immune Response. AU - Heijnen, Bart F. J.. AU - Nelissen, Jelly. AU - van Essen, Helma. AU - Fazzi, Gregorio E.. AU - Tervaert, Jan W. Cohen. AU - Peutz-Kootstra, Carine J.. AU - Mullins, John J.. AU - Schalkwijk, Casper G.. AU - Janssen, Ben J. A.. AU - Struijker-Boudier, Harry A. J.. PY - 2013/2/28. Y1 - 2013/2/28. U2 - 10.1371/journal.pone.0057815. DO - 10.1371/journal.pone.0057815. M3 - Article. VL - 8. JO - PLOS ONE. JF - PLOS ONE. SN - 1932-6203. IS - 2. M1 - e57815. ER - ...
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to its apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.. Two of the main actions of apelin are to increase the pumping ability of the heart and cause blood vessels to relax. The investigators wish to assess if these actions are altered in the setting of normal renin-angiotensin activation and increased renin-angiotensin activity. ...
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The kidney is an organ in our body that resembles like bean. This organ performs several essential functions to save our body from the various diseases; this organ also serves as natural filter of the blood. Kidney is a very important organ of the body because it is responsible for the re-absorption of water, glucose Read more ...
TY - JOUR. T1 - A RENIN-ANGIOTENSIN RENDSZER SZEREPENEK VIZSGALATA AZ ALDOSTERON. AU - SOLYOM, J.. AU - KOTRA, Z.. AU - SALAMON, A.. AU - STURCZ, J.. PY - 1964/12/1. Y1 - 1964/12/1. UR - http://www.scopus.com/inward/record.url?scp=78651161563&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=78651161563&partnerID=8YFLogxK. M3 - Article. C2 - 14135703. AN - SCOPUS:78651161563. VL - 16. SP - 96. EP - 100. JO - Kiserletes Orvostudomany. JF - Kiserletes Orvostudomany. SN - 0023-1878. ER - ...