Definition of intravenous anesthetic in the Definitions.net dictionary. Meaning of intravenous anesthetic. What does intravenous anesthetic mean? Information and translations of intravenous anesthetic in the most comprehensive dictionary definitions resource on the web.

The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients ...

A new business intelligence report released by Contrive Datum Insights with the title Global Intravenous Anesthetics Market 2020 by Manufacturers, Type and Application, forecast to 2027 is designed with an objective to provide a micro-level analysis of the market. The report offers a comprehensive study of the current state expected at the major drivers, market strategies, and key vendors growth. The report presents energetic visions to conclude and study the market size, market hopes, and competitive surroundings. The research also focuses on the important achievements of the market, Research & Development, and regional growth of the leading competitors operating in the market. The current trends of the global Intravenous Anesthetics market in conjunction with the geographical landscape of this vertical have also been included in this report ...

The clinical studies demonstrate more powerful analgesic effect among female to both μ- and κ-opioid agonist (Fillingim et al. 2004). The antitussive effect of opioid is mediated predominantly by μ-, κ-opioid receptors (Kamei J. 1996). Therefore, the investigators hypothesized that there are sex differences in the antitussive responses to opioid.. It has been reported that target-controlled infusion (TCI) of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. Some studies, reporting the EC50 and EC95 of remifentanil in effect-site TCI for preventing cough during emergence in different sex and surgeries (B. Lee et al. 2009, E.M.Choi et al. 2012), showed differences in EC50 and EC95.. The purpose of this study was to find out EC50 and EC95 of remifentanil in effect-site TCI for preventing cough during emergence in each sex and to evaluate whether there were sex differences in EC50 and EC95 of remifentanil in effect-site TCI or not. ...

Modulation of hECN GABAARs by intravenous anesthetics, SCS, furosemide and zolipidemA, upper panel: example trace showing potentiation of GABA-mediated whole-ce

1. Weerink MAS, Struys MMRF, Hannivoort LN, Barends CRM, Absalom AR, Colin P. Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. Clinical Pharmacokinetics. 2017;56:893-913 2. Mohammadi B, Haeseler G, Leuwer M, Dengler R, Krampfl K, Bufler J. Structural requirements of phenol derivatives for direct activation of chloride currents via GABAA receptors. European Journal of Pharmacology. 2001;421:85-91 3. Reiner GN, Delgado-Marín L, Olguín N, Sánchez-Redondo S, Sánchez-Borzone M, Rodríguez-Farré E, Suñol C, García DA. Gabaergic Pharmacological Activity of Propofol Related Compounds as Possible Enhancers of General Anesthetics and Interaction with Membranes. Cell Biochemistry and Biophysics. 2013;67:515-525 4. Álvaro-Bartolomé M, Salort G, García-Sevilla JA. Disruption of brain MEK-ERK sequential phosphorylation and activation during midazolam-induced hypnosis in mice: Roles of GABAA receptor, MEK1 inactivation, and phosphatase MKP-3. Progress in Neuro-Psychopharmacology & ...

Principal Investigator：KURODA Toshihisa, Project Period (FY)：1992 - 1994, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：麻酔学

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OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. ...

Emergent or elective surgical procedures under general anesthesia may be required during pregnancy for some patients. For this reason, effects of anesthetics on uterine contractions are important. General anesthesia is not limited to the administration of inhalation agents, since induction and maintenance of anesthesia usually involve intravenous administration of different anesthetic agents. The effects of these agents on uterine contractions and blood flow are very important. The unexpected relaxation or contraction of myometrium can be harmful to fetus and continuing pregnancy. Our aim in this study is to investigate the effects of intravenous anesthetic agents on uterine contractions. ...

Background and study aims : In endoscopic procedures, propofol can be safely administered either alone or in conjunction with remifentanil. The aim of the study is to compare the effects of the administration of propofol alone and the administration of remifentanil in addition to propofol on patient and endoscopist satisfaction, preoperative hemodynamic response, and propofol consumption. ...

TY - JOUR. T1 - Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat. T2 - Correlation with plasma concentration. AU - Yang, Chen Hsein. AU - Shyr, M. H.. AU - Kuo, T. B.J.. AU - Tan, P. P.C.. AU - Chan, S. H.H.. PY - 1995. Y1 - 1995. N2 - We applied simultaneous spectral analysis of electroencephalographic (EEG) and systemic arterial pressure signals in Sprague-Dawley rats to monitor the status of consciousness and cardiovascular functions during intravenous anesthesia with propofol and to assess their correlations with plasma propofol concentration. Our results support the hypothesis that a threshold plasma concentration (1.7-1.8 μg/ml) exists for propofol anesthesia. This threshold level, we further showed, may be attained by both i.v. bolus injection and continuous infusion, although the pharmacokinetic profiles, as well as EEG and hemodynamic correlates, may be different. Continuous, on- line power ...

BACKGROUND: The Narcotrend is a new electroencephalographic monitor designed to measure depth of anesthesia, based on a six-letter classification from A (awake) to F (increasing burst suppression) including 14 substages. This study was designed to investigate the impact of Narcotrend monitoring on recovery times and propofol consumption in comparison to Bispectral Index (BIS) monitoring or standard anesthetic practice.. METHODS: With institutional review board approval and written informed consent, 120 adult patients scheduled to undergo minor orthopedic surgery were randomized to receive a propofol-remifentanil anesthetic controlled by Narcotrend, by BIS(R), or solely by clinical parameters. Anesthesia was induced with 0.4 micro x kg-1 x min-1 remifentanil and a propofol target-controlled infusion at 3.5 microg/ml. After intubation, remifentanil was reduced to 0.2 micro x kg-1 x min-1, whereas the propofol infusion was adjusted according to clinical parameters or to the following target values: ...

Background: Propofol is a short-acting intravenous anesthetic agent. In rare conditions, a life-threatening complication known as propofol infusion syndrome can occur. The pathophysiologic mechanism is still unknown. Some studies suggested that propofol acts as uncoupling agent, others suggested that it inhibits complex I or complex IV, or causes increased oxidation of cytochrome c and cytochrome aa(3), or inhibits mitochondrial fatty acid metabolism. Although the exact site of interaction is not known, most hypotheses point to the direction of the mitochondria. Methods: Eight rats were ventilated and sedated with propofol up to 20 h. Sequential biopsy specimens were taken from liver and skeletal muscle and used for determination of respiratory chain activities and propofol concentration. Activities were also measured in skeletal muscle from a patient who died of propofol infusion syndrome. Results: In rats, authors detected a decrease in complex II+III activity starting at low tissue ...

TY - JOUR. T1 - Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling. AU - Hsing, Chung-Hsi. AU - Lin, Ming-Chung. AU - Choi, Pui-Ching. AU - Huang, Wei-Ching. AU - Kai, Jui-In. AU - Tsai, Cheng-Chieh. AU - Cheng, Yi-Lin. AU - Hsieh, Chia-Yuan. AU - Wang, Chi-Yun. AU - Chang, Yu-Ping. AU - Chen, Yu-Hong. AU - Chen, Chia-Ling. AU - Lin, Chiou-Feng. PY - 2011. Y1 - 2011. N2 - Background: Anesthetic propofol has immunomodulatory effects, particularly in the area of anti-inflammation. Bacterial endotoxin lipopolysaccharide (LPS) induces inflammation through toll-like receptor (TLR) 4 signaling. We investigated the molecular actions of propofol against LPS/TLR4-induced inflammatory activation in murine RAW264.7 macrophages. Methodology/Principal Findings: Non-cytotoxic levels of propofol reduced LPS-induced inducible nitric oxide synthase (iNOS) and NO as determined by western blotting and the Griess reaction, respectively. ...

Phaxan™ is an intravenous general anaesthetic and sedative containing alphaxalone as the active pharmaceutical ingredient. Alphaxalone is a neuroactive steroid anaesthetic. It is a pregnanedione with no endocrine hormonal activity. This water-insoluble drug was initially formulated using CremophorEL and marketed as Althesin® from 1972 to 1984. It was found to be a safe and versatile intravenous anaesthetic used in clinical practice in anaesthesia and intensive care in many countries until it was withdrawn from clinical practice because of hypersensitivity to the CremophorEL.. Many subsequent attempts to make an aqueous formulations of neuroactive steroids suitable for human use have failed. Drawbridge Pharmaceuticals proprietary and patented formulation, Phaxan™, is a solution of alphaxalone 10mg/ml dissolved in 13% SBECD (7- sulfobutylether β-cyclodextrin); a molecule with a lipophilic cavity that enables drug dispersal in water for human use. The use of SBECD as the excipient preserves ...

Anesthesia is the procedure to ensure the absence of pain, the inhibition of autonomic reactions and a good surgical. Today, most anesthetic procedures involve the combination of different drugs, using anesthetics at considerably lower concentrations if compared to those that would be needed if they were used without association; modern anesthetic techniques typically involve the association of hypnotics, analgesics, and muscle relaxants [1].. The use of barbiturates as intravenous anesthetics have been tested in the last 70 years; among these, propofol (2,6-diisopropylphenol) was introduced clinically in 1977 and demonstrates many positive effects [2]. Because of its unique pharmacological properties [3], it is an anesthetic drug used in the induction and maintenance of anesthesia in adults, being popular for providing an easy induction and recovery is faster than other drugs, such as thiopental [4]. Sedation with propofol does not provide relief from pain, however it provides anxiolysis, ...

Objectives This study evaluated the effects of sevoflurane and propofol anesthesia on renal function of dogs with naturally acquired chronic renal failure. Materials & Methods The anesthetic procedures included: three hours using sevoflurane (1.5CAM) in O2 flow of 30mL/kg/min, in a semiclosed-circuit, after induction with propofol at 10mg/kg, in bolus (P-S group), or after induction with sevoflurane (S-S group), and for the P group it was used only propofol in the same dose employed for induction. Evaluations were performed in six sessions and included creatinine clearance, serum creatinine and ureia, protein and glucose urinary excretion. The renal function evaluations were performed 30 minutes before anesthesia, two times during anesthesia, and one, two and five days after. Results All anesthetic procedures were well succeeded and animals recovered uneventfully. No renal toxicity were observed in any of the anesthetic protocols. However, during the transanesthetic period it was observed ...

Propofol is a general anesthetic commonly used in pediatric clinical practices. Experimental findings demonstrate that anesthetics induce widespread apoptosis and cognitive decline in a developing brain. Although anesthesia-mediated neurotoxicity is the most prominent during intense period of synaptogenesis, the effects of an early anesthesia exposure on the synapses are not well understood. The aim of this study was to examine the effects of neonatal propofol anesthesia on the expression of key proteins that participate in synaptogenesis and synaptic plasticity and to evaluate long-term neurobehavioral abnormalities in the mature adult brain. Propofol-injected 7-day-old rats were maintained under 2-, 4-, and 6-h-long anesthesia and sacrificed 0, 4, 16, and 24 h after the termination of each exposure. We showed that propofol anesthesia strongly influenced spatiotemporal expression and/or proteolytic processing of crucial presynaptic (GAP-43, synaptophysin, α-synuclein), trans-synaptic ...

Uncertainty exists as to the most suitable pharmacokinetic parameter sets for propofol target-controlled infusions (TCI). The pharmacokinetic parameter sets currently employed are clearly not universally applicable, particularly when patient attributes differ from those of the subjects who participated in the original research from which the models were derived. Increasing evidence indicates that the pharmacokinetic parameters of propofol can be scaled allometrically as well as in direct proportion to lean body mass (LBM). Appraisal of hitherto published studies suggests that an allometrically scaled pharmacokinetic parameter set may be applicable to a wide range of patients ranging from children to obese adults. On the other hand, there is evidence that propofol pharmacokinetic parameters, scaled linearly to LBM, provide improved dosing in normal and obese adults. The Schnider pharmacokinetic parameter set that has been programmed into commercially available TCI pumps cannot be employed at ...

Propofol is a widely used intravenous anesthetic agent with antioxidant properties secondary to its phenol based chemical structure. Treatment with propofol has been found to attenuate oxidative stress and prevent ischemia/reperfusion injury in rat heart. Here, we report that propofol protects cardiac H9c2 cells from hydrogen peroxide (H2O2)-induced injury by triggering the activation of Akt and a parallel up-regulation of Bcl-2. We show that pretreatment with propofol significantly protects against H2O2-induced injury. We further demonstrate that propofol activates the PI3K-Akt signaling pathway. The protective effect of propofol on H2O2-induced injury is reversed by PI3K inhibitor wortmannin, which effectively suppresses propofol-induced activation of Akt, up-regulation of Bcl-2, and protection from apoptosis. Collectively, our results reveal a new mechanism by which propofol inhibits H2O2-induced injury in cardiac H9c2 cells, supporting a potential application of propofol as a preemptive ...

Principal Investigator：MASUDA Akira, Project Period (FY)：1997 - 1998, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Anesthesiology/Resuscitation studies

Authorities Focus on Propofol as Central Element in Jacksons DeathThe powerful anaesthetic that investigators believe killed Michael Jackson came from a Ne...

In humans, prolonged sedations with propofol or using high doses have been associated with propofol infusion syndrome. The main objective of this study was to evaluate the effects of prolonged high-dose administration of a specific propofol emulsion (Propofol Lipuro) and an improved lipid formulation (SMOFlipid) in liver mitochondrial bioenergetics and oxidative stress of rabbits, comparatively to a saline control. Twenty-one male New Zealand white rabbits were randomly allocated in three groups that were continuously treated for 20 h. Each group of seven animals received separately: NaCl 0.9 % (saline), SMOFlipid (lipid-based emulsion without propofol) and Lipuro 2 % (propofol lipid emulsion). An intravenous propofol bolus of 20 mg kg−1 was given to the propofol Lipuro group to allow blind orotracheal intubation and mechanical ventilation. Anesthesia was maintained using infusion rates of: 20, 30, 40, 50 and 60 mg kg−1 h−1, according to the clinical scale of anesthetic depth and the index of

Propofol reportedly possesses potential antioxidant properties caused by its chemical structure similar to that of phenol-based free-radical scavengers such as vitamin E.10 Previous in vivo or in vitro studies documented that this intravenous anesthetic reduces oxidative stress toward blood vessels.11,12 These results suggest that this anesthetic may be protective against the vascular dysfunction caused by increased oxidative stress. Indeed, propofol (3 × 10−7to 10−6m) recovered vascular ATP-sensitive K+channel function via reduction of superoxide levels within arterial walls. In addition, 10−6m of this agent completely inhibited protein expression of a Nox2-related NADPH oxidase subunit p47phox. The plasma concentration of propofol during induction of anesthesia in humans has been reported as up to 3 × 10−5m, and burst suppression doses of propofol for cerebral protection are up to 6 × 10−5m.20-22 Effective concentrations of propofol (3 × 10−7to 10−6m) to inhibit NADPH oxidase ...

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Author: Driscoll David F, Deaconess Beth Israel, Lawrence Kenneth R, Lewis Keith, Bistrian Bruce R, Year: 1997, Abstract: The Centers for Disease Control has identified intravenous propofol, a lipid-based medication, as a cause of postoperative infections in hospitalized patients. It appears the increased risk results from poor aseptic technique in the preparation, storage and administration of extemporaneously prepared propofol infusions. An additional risk of preparing propofol injection includes glass particulate contamination when the ampule dosage form is used. The current study, therefore, examines th

Dr. Conrad Murray, who has been convicted of killing Michael Jackson by giving him a lethal drug doze, has asked appellate judges to authorize forensic analysis of the bottle of the anesthetic propofol recovered from the bedroom where the pop legend died in 2009.

A popular method of administering intravenous anesthetics is as a continuous infusion. To improve the accuracy of infusion delivery, computerized infusion pumps that use pharmacokinetic models have been developed to quickly achieve and maintain desired target effect-site concentrations. This delivery technique, known as target-controlled infusions (TCI), has become popular worldwide. Unfortunately, neither have models used to drive TCI been validated in obese patients nor has agreement regarding the correct weight to input been identified. Most models were developed with normal-sized patients or volunteers and extrapolated for use in larger patients. The main limitation is that the composition of normal size and obese patients is not the same; hence, kinetic model predictions are likely to be less accurate in the obese. ...

The aim of this work was to establish the correlation between the bispectral index (BIS) and different rates of continuous infusion of propofol. Twenty-four adult dogs were randomly divided into 3 groups (P2, P4, P8). All animals were induced with propofol (10 mg/kg/IV), followed immediately by the continuous infusion of the agent: 0.2 mg/kg/min (P2), 0.4 mg/kg/min (P4) and 0.8 mg/kg/min (P8). The BIS values were measured before any drug administration (M0) and 10, 20, 30, 40 and 50 minutes after the start of the continuous infusion of propofol. The Analysis of Variance was used to calculate the correlation between the infusion rates of propofol and the BIS values. BIS demonstrated significant difference between groups at the moment M40, where P8 (72 ± 9,7) was smaller than P2 (84 ± 7,4) and P4 (33 ± 8,5), while in M50 this difference was observed in P8 (69 ± 13,5) that was smaller than P2 (84 ± 6,4).. The effects of induction dose of propofol were not more presented in M40, therefore, the ...

Evaluation of efficacy of priming dose of propofol in reducing induction dose requirements in patients undergoing elective surgeries under general anaesthesia

Second, whatever the cause of pain in veins, the perception of pain is the same because of the polymodal nociceptors that transmit their information via A [Greek small letter delta] fibers [3]; to abolish the injection pain of propofol, a method that can block A [Greek small letter delta] fibers must be used. Unfortunately, we do not think that propofol at 4 [degree sign]C or 37 [degree sign]C has such an effect. So we do not think that the effect of changes in the temperature of propofol are relevant.. ...

Modeling is a valuable tool in drug development, to support decision making, improving study design, and aid in regulatory approval and labeling. This thesis describes the development of pharmacometric models for drugs used in anesthesia and analgesia.. Models describing the effects on anesthetic depth, measured by the bispectral index (BIS), for a commonly used anesthetic, propofol, and for a novel anesthetic, AZD3043, were developed. The propofol model consisted of two effect-site compartments, and could describe the effects of propofol when the rate of infusion is changed during treatment. AZD3043 had a high clearance and a low volume of distribution, leading to a short half-life. The distribution to the effect site was fast, and together with the short plasma half-life leading to a fast onset and offset of effects. It was also shown that BIS after AZD3043 treatment is related to the probability of unconsciousness similar to propofol.. In analgesia studies dropout due to lack of efficacy is ...

The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and topological domains, testing them on functional MRI BOLD signal data obtained from individuals undergoing various levels of sedation with the anaesthetic agent propofol, replicating our results in two separate datasets. We demonstrate that the various measures are differently able to discriminate between levels of sedation, with temporal measures showing higher sensitivity. Further, we show that all measures are strongly related to a single underlying construct explaining most of the variance, as assessed by Principal Component Analysis, which we interpret as a measure of

Title: Propofol in Anesthesia. Mechanism of Action, Structure-Activity Relationships, and Drug Delivery. VOLUME: 7 ISSUE: 2. Author(s):Giuseppe M. Trapani, Cosimo Altomare, Enrico Sanna, Giovanni Biggio and Gaetano Liso. Affiliation:CHUL Research Center,2705 Laurier Blvd, Quebec (Quebec) G1V 4G2, Canada. Keywords:propofol, 2 diisoprovpylphenol, drug delivery, aminobutyric acid GABA, GABAa receptor, site specific chemical delivery system CDS, cloned GABA A Receptor, anticonvulsant, anxiolytic effects, alkylphenols, hypnotic activity, STERIMOL Descriptors, pharmacokinetic, drug monitoring, metabolism, toxicology, salmonella mutation, lipid formulations, saccharomices cerevisiae, prodrugs, chemical delivery systems CDS, target controlled infusion TCI, CLINICAL USE, Anesthesia, tomidate. Abstract: Propofol (2,6-diisopropylphenol) is becoming the intravenous anesthetic of choice for ambulatory surgery in outpatients. It is extensively metabolized, with most of the administered dose appearing in the ...

Methods: Preparation of propofol nanoemulsion using NEMS™ technology has been performed for propofol 1% in NEMS™ (P1%), and propofol 2% in NEMS™ (P2%). Determination of free propofol concentration in aqueous phase was conducted using HPLC and rat paw lick test was evaluated as in vivo test to assay the intensity of pain on injection site. The sleep recovery test was conducted to evaluate the pharmacological effect and erythrocyte hemolysis test also conducted to ensure the safety of propofol in NEMS™. All of the test results were compared with Diprivan®1% as a positive standard. ...

Consciousness is regained in 5-15 min due to the concept of redistribution of the drug into highly perfused organs first and then to the low perfused organs like fat and muscles ...

PROPOFOL (injection, emulsion) comes in different strengths and amounts. The appearance of Propofol can differ based on the dosing.

Lee, T.-L.,Adaikan, P.G.,Lau, L.C.,Kumar, A.,Ratnam, S.S. (1997). Effects of propofol on gravid human uterine muscle. Journal of Anesthesia 11 (1) : 71-74. ScholarBank@NUS Repository. https://doi.org/10.1007/BF02480008 ...

Fingerprint Dive into the research topics of Effects of propofol on Ca,sup,2+,/sup, regulation by malignant hyperthermia- susceptible muscle membranes. Together they form a unique fingerprint. ...

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Methods All dogs were premedicated with methadone, 0.2 mg kg−1 intramuscularly 30 minutes prior to induction of anaesthesia. Anaesthesia was induced with propofol administered intravenously (IV) to effect, following administration of lidocaine 1 mg kg−1 IV and maintained with a continuous infusion of propofol at ≤0.4 mg kg−1 minute−1 during instrumentation and preparation and during movement of the animals to recovery. During surgery, anaesthesia was maintained using a continuous infusion of propofol at ≤0.4 mg kg−1 minute−1and alfentanil ≤1 μg kg−1 minute−1. Lidocaine was administered at 1 mg kg−1 IV immediately prior to extubation. Arterial blood pressure and heart rate (HR) were recorded prior to induction and every 5 minutes throughout preparation and surgery. Central venous pressure was recorded every 5 minutes throughout surgery ...

The Dyck parameter set was derived from arterial blood samples and the Marsh set from a modification of a model published by White and Kenny [28] and Gepts et al., [29] in which arterial sampling was performed. The Tackley set was calculated after venous sampling. When comparing predicted and measured concentrations, the sampling site used for modeling and for evaluation and the time of sampling may influence the results. Chiou [30,31] has reviewed the phenomenon of dependence of drug concentration on sampling site and has pointed out that profiles of concentration in blood or plasma from different sampling sites can lead to the calculation of widely differing pharmacokinetic parameters. The significant arteriovenous propofol concentrations occurring during our TCI study differ from the findings of Major et al., [32] who, using the previous propofol formulation in Cremophor-EL found negligible AV differences in concentration after a single propofol dose (2 mg/kg administered over a 60-s period) ...

Diagnosis Code T41.1X1A information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.

A novel strategy of propofol anesthesia is proposed to improve clinical propofol anesthesia for hypothermic decompression. Theoretical analysis is...

I think every high-profile case has its own problems that are associated with them, Geragos said. One of them is the media and having to deal with the media and the constant onslaught of being second-guessed. Having all that kind of stuff that floats around the case that has nothing to do with what goes on in the courtroom. You have to filter that out, you have to kind of hunker down and try to just let that water drip off your back ...

Upon waking: talkative, high, felt drugged It has been reported that propofol injection pain (PIP) occurred in 60% of untreated patients . The doctor there called my condition life threatening. J Clin Exp Hepatol. Send thanks to the doctor. 5=HIGH (this medicine cured me or helped me a great deal. SIDE EFFECTS FOR PROPOFOL: COMMENTS: SEX: AGE: DURATION/ DOSAGE: DATE ADDED : 1: Colonoscopy: Nausea, bloody nose, hoarse, coughing up bloody mucous day after, upper respiratory infection, chills : Never again: 55 0 days: 11/26/2019: 1: Cardiac cath: Severe stomach issues still occurring 8 days following 3 hours of propofol: Headaches for 3 days, fatigue and severe abdominal … Also I felt very fatigue, as well as some light headed. Based on sedative effect and side effects, the dose was increased or decreased in the next 5 patients until the optimal dose was found. I did it last time with no side effects. Bronchospasm 10. Druginformer Identified Side Effects: Fatigue, Lethargy, Mood altered, ...

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Background and purpose: The aim of this prospective, clinical trial study was to investigate whether the administration of different doses of ketamine before induction with propofol imporves its associated haemodynamic propofol during induction and tracheal intubation. Materials and Methods: One hundered and thirty adult patients ASA I were randomly allocated to ...

Background and purpose: The aim of this prospective, clinical trial study was to investigate whether the administration of different doses of ketamine before induction with propofol imporves its associated haemodynamic propofol during induction and tracheal intubation. Materials and Methods: One hundered and thirty adult patients ASA I were randomly allocated to ...

4. Kurita TUraoka MMorita KSuzuki MMorishima YSato S: Influence of haemorrhage on the pseudo-steady-state remifentanil concentration in a swine model: a comparison with propofol and the effect of haemorrhagic shock stage. Br J Anaesth 107:719-7252011. ...

MATA, Lukiya Birungi Silva Campos et al. Anestesia por infusão contínua de propofol associado ao remifentanil em gatos pré-tratados com acepromazina. Rev. Ceres [online]. 2010, vol.57, n.2, pp.198-204. ISSN 0034-737X. https://doi.org/10.1590/S0034-737X2010000200010.. O presente trabalho avaliou a associação anestésica do propofol, um anestésico geral de ação ultracurta e metabolismo rápido, ao remifentanil, opioide de grande poder analgésico, que potencializa os anestésicos gerais. O objetivo principal foi desenvolver um protocolo anestésico de uso intravenoso, por infusão contínua, que proporcione conforto ao paciente, segurança, com grande relaxamento muscular e analgesia em gatos submetidos a cirurgias eletivas como a ovariosalpingoisterectomia e orquiectomia. Foram utilizados 30 gatos, aleatoriamente distribuídos em 3 grupos de 10 animais. Em todos eles realizou-se a tranquilização com acepromazina (0,1 mg/kg, IM) e indução anestésica com propofol (6 mg/kg, IV). No ...