Modafinil is a non-amphetamine type stimulant that acts as a wakefulness-promoting drug, and is approved for managing symptoms of narcolepsy (i.e., daytime somnolence). Its precise mechanism of action in promoting wakefulness remains unclear. This trial is a placebo-controlled double-blind trial of modafinil, on a platform of contingency management (CM) and individual cognitive-behavioral (CBT) counseling, for the treatment of methamphetamine dependence. Participants in this study will complete a 2-week baseline screening period during which they will provide urine samples and complete physical and psychological assessments to establish their eligibility for the study. In addition, participants will be asked to provide a blood or saliva specimen for genetic testing in order to identify genetic variations that influence response to methamphetamine and to treatment with modafinil. Upon successful completion of screening, participants will be randomly assigned to receive either modafinil (400mg qd) ...
TY - JOUR. T1 - Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms. AU - Ide, S.. AU - Kobayashi, H.. AU - Ujike, H.. AU - Ozaki, N.. AU - Sekine, Y.. AU - Inada, T.. AU - Harano, M.. AU - Komiyama, T.. AU - Yamada, M.. AU - Iyo, M.. AU - Iwata, N.. AU - Tanaka, K.. AU - Shen, H.. AU - Iwahashi, K.. AU - Itokawa, M.. AU - Minami, M.. AU - Satoh, M.. AU - Ikeda, K.. AU - Sora, Ide. N1 - Funding Information: We are grateful to the Japanese Ministry of Health, Labour and Welfare (MHLW) as well as to the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) for support in part by Grants MHLW13-040, MHLW15-7, MHLW17-pharmaco-001, MEXT15025206 and MEXT15029204.. PY - 2006/5. Y1 - 2006/5. N2 - Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene ...
The high rate of meth use among MSM is paralleled by evidence of rises in sexual risk behavior and HIV infection among this population. The MSM meth epidemic, and its link with HIV transmission, underscores the need to pilot test new, innovative modalities to reduce meth use and meth-associated sexual risk behavior. Ultimately, a pharmacologic treatment for meth use may not only serve to improve outcomes among those who are accessing current treatment services, but might also benefit those who are not willing or able to utilize such services. While studies show that MSM who enter substance use treatment decrease both their substance use and sexual risk behavior, current behavioral meth treatment programs report low rates of success in treating meth dependence among MSM. We believe the time has come to test the acceptability of pharmacologic interventions to reduce meth use among MSM, and to assess the feasibility of conducting such trials among sexually active, meth-dependent MSM, whose ...
Learn the behavioral, physical and psychological signs and symptoms of amphetamine abuse now. Amphetamine abuse symptoms - Amphetamines are stimulants that may be prescribed by a doctor to treat several conditions including: Narcolepsy.
Stimulant use disorder is a type of substance use disorder that involves the abuse of stimulants. It is defined in the DSM-5 as the continued use of amphetamine-type substances, cocaine, or other stimulants leading to clinically significant impairment or distress, from mild to severe. These psychoactive drugs, known as stimulants, are the most widely used drugs in the world today. Approximately 200 million Americans have used some type of a stimulant in the past year alone. A psychoactive drug, such as a stimulant, is a chemical or substance that effects ones behavior, mind, and body. A stimulant can be smoked, injected, snorted, taken in pill form, chewed and even ingested in the form of a drink. Synthetic stimulants are becoming increasingly popular as users attempt to alter the chemicals in drugs to create different reactions, and ultimately steer clear of jail time, legal penalties and detection in drug screening efforts. If a substance is used over a long period of time and the user ...
I URGE ALL MY FRIENDS TO READ & SHARE THIS; YOU COULD SAVE A LOVED ONES LIFE BY KNOWING THIS SIMPLE INFORMATION!!! Stroke has a new indicator! They say if you forward this to ten people, you stand a chance of saving one life. Will you send this along? Blood Clots/Stroke - They Now Have a Fourth Indicator, the Tongue: During a BBQ, a woman stumbled and took a little fall - she assured everyone that she was fine (they offered to call paramedics) ...she said she had just tripped over a brick because of her new shoes. They got her cleaned up and got her a new plate of food. While she appeared a bit shaken up, Jane went about enjoying herself the rest of the evening. Janes husband called later telling everyone that his wife had been taken to the hospital - (at 6:00 PM Jane passed away.) She had suffered a stroke at the BBQ. Had they known how to identify the signs of a stroke, perhaps Jane would be with us today. Some dont die. They end up in a helpless, hopeless condition instead. It only takes a ...
Find a doctor in Fayetteville, WV who treats Amphetamine Abuse/dependence with Lifescript Doctor Finder. Search 720,000 doctors by specialty, condition, location, insurance.
Find a doctor in Wayne, WV who treats Amphetamine Abuse/dependence with Lifescript Doctor Finder. Search 720,000 doctors by specialty, condition, location, insurance.
Learn about amphetamine addiction signs, side effects, causes, symptoms & withdrawals from amphetamine abuse. Acadiana Treatment Center
When its time to talk about amphetamine abuse with your college-aged son or daughter, make sure to explain your reasons for the talk and to stay calm.
Hair analysis is a reliable tool for detecting long-term exposure to illegal drugs, including amphetamine-type stimulants, over periods from a few weeks to a few months, depending on the length of the hair used for analysis. Between 2000...
They said their new study adds to evidence about the need to tackle the global stimulant epidemic.. The investigators were led by Stuart Reece, a clinical associate professor at the University of Western Australia. They assessed arterial stiffening in more than 700 Australians in their 30s and 40s. Arteries tend to harden with age.. Those participants who used illegal amphetamines showed greater aging of the arteries than others, including those who smoked tobacco or used the heroin substitute methadone, the study reported.. The link between illegal amphetamine use and greater aging of the arteries was seen in men and women. It was also independent of other risk factors for heart disease and stroke, Reece and his colleagues said.. ...
SAMHSA has introduced the Matrix Intensive Outpatient Treatment for People With Stimulant Use Disorders Family Education Videos, which are intended to educate family members of those in recovery about substance use disorders.. The videos include interviews of people in recovery and their loved ones and provide key information for those supporting people in treatment and recovery. They were made to be used with the Matrix Intensive Outpatient Treatment for People With Stimulant Use Disorders series.. There are three sets of videos:. ...
Amphetamine addiction has become common with the usage of drugs such as benzedrine & adderall. Read about the effects & treatment for amphetamine dependency.
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Using a Modified Intervention Mapping Approach to Develop and Refine a Single-Session Motivational Intervention for Methamphetamine-Using Men Who Have Sex With Men
Clinical Services provided for Substance Abuse: * Alcohol Abuse * Cannibis Abuse * Opioid Abuse * Amphetamine Abuse * Prescription Medication
Clinical Services provided for Substance Abuse: * Alcohol Abuse * Cannibis Abuse * Opioid Abuse * Amphetamine Abuse * Prescription Medication
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TY - JOUR. T1 - Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. AU - Volkow, N. D.. AU - Chang, L.. AU - Wang, G. J.. AU - Fowler, J. S.. AU - Franceschi, D.. AU - Sedler, M. J.. AU - Gatley, S. J.. AU - Hitzemann, R.. AU - Ding, Y. S.. AU - Wong, C.. AU - Logan, J.. PY - 2001/3/21. Y1 - 2001/3/21. N2 - Objective: Methamphetamine has raised concerns because it may be neurotoxic to the human brain. Although prior work has focused primarily on the effects of methamphetamine on dopamine cells, there is evidence that other neuronal types are affected. The authors measured regional brain glucose metabolism, which serves as a marker of brain function, to assess if there is evidence of functional changes in methamphetamine abusers in regions other than those innervated by dopamine cells. Method: Fifteen detoxified methamphetamine abusers and 21 comparison subjects underwent positron emission tomography following administration of [18F]fluorodeoxyglucose. Results: ...
If you take methamphetamine, you should understand its potential for dependence and addiction. Learn the signs and symptoms and how to treat it.
Memory is a complex of systems by which an organism registers, stores and retrieves exposure to an event or experience. Literature purports that methamphetamine users and dependents have been found to exhibits signs of memory impairment. The aim of the research was to establish the possible existence of significant differences in memory in current methamphetamine users, recovering methamphetamine users, and a matched drug naïve control group. Cognitive functioning was assessed via a neurocognitive test battery that examined the memory of 14 current methamphetamine users, 17 recovering methamphetamine addicts, and 18 drug naïve control participants who were matched according to the demographic variables of age, gender and educational status. The results indicated that recovering methamphetamine users experienced the greatest impairment in memory in comparison to both the control group and current users of methamphetamine. The current users of methamphetamine also experienced some impairment in memory
The article describes a study done by eight professors from UCLA where they observed methamphetamine users dental health. The article provides statistics from the study about the prevalence of gum disease and cavities in methamphetamine users.
Many people that struggle with Methamphetamine Abuse care for nothing but their high, so their unaware of the deadly Methamphetamine Abuse Symptoms.
Methamphetamine use has increased substantially in the United States since the 1990s. Few studies have examined the healthcare service needs of women who use methamphetamine. This study describes unmet medical needs in a community-based sample of women who use methamphetamine in San Francisco, CA. Women who use methamphetamine were recruited in San Francisco and participated in a computer-assisted survey (N = 298 HIV-negative women).
The rise in methamphetamine use among gay and bisexual men in urban centers over the past 10 years has resulted in a greater understanding of the biologic, psychologic, and cultural dimensions of the problem, as well as the development of specific treatments for this patient population. Culturally informed individual counseling and group psychotherapy, based on the principles of motivational interviewing and organized around the Matrix Model, appear to be most effective in the outpatient management of this difficult illness. Pharmacotherapy is limited to the treatment of co-occurring psychiatric disorders.. ...
A 2015 study published in the DARU Journal of Pharmaceutical Sciences from the Faculty of Sciences presented a random, double blind, placebo-controlled analysis of the treatment process involving participants with a methamphetamine dependency and sustained-release methylphenidate (MPH-SR).. Methylphenidate also known as Ritalin is a stimulant for the central nervous system, which can commonly be used for conditions like Attention Deficit Hyperactivity Disorder and Narcolepsy.. Fifty-six mixed gender participants from 18-65 years old attending outpatient clinics were randomly placed into two groups, treatment or placebo. The treatment group received 18-54 mg of MPH-SR for 10 weeks ...
Iranian Rehabilitation Journal - Iranian Rehabilitation Journal - People with special needs - special olympics - Dohsa-hou - Asghar Dadkhah - University of social welfare and rehabilitation sciences
Last decade, positive drug tests among U.S. workers for methamphetamine had started to drop. That trend may be reversing, with positive rates dramatically higher in some states compared to others. The new statistics come from Quest Diagnostics annual report on U.S. worker drug use, based on more than six million urine tests collected from January-December 2010.. Positives for methamphetamine use in the U.S. general workforce dropped dramatically from 0.18% in 2006 to 0.11% in 2008. However, the rate remained the same in 2009 and 2010 at 0.10%.. Dr. Steven Shoptaw, a researcher who studies therapies for methamphetamine dependence, says, Ive worked with patients who, paralyzed by the recession and juggling multiple jobs and family responsibilities, started using methamphetamine for its functional stimulant benefit.. Shoptaw notes that, even when its used as a stimulant by people who work more than one job, meth can wreak havoc on their judgment.. For these sort of people, we now provide ...
In the study published in Addiction Biology, researchers from three Taiwanese institutions explored the potential role of declining levels of a protein called BDNF in promoting the brain damage found in chronic methamphetamine abusers and addicts. Under normal circumstances, BDNF provides the brain with critical protection by helping nerve cells grow, reach maturity and stay in good working order. In addition, the protein plays an essential role in basic brain functionality by supporting the chemical and physical adaptations required for learning new information and storing that information in memory.. For their study, the researchers recruited 59 people diagnosed with methamphetamine abuse, as well as a second group of 59 generally healthy individuals who did not use the drug. The methamphetamine abusers had stopped actively taking the drug and were in the early stages of withdrawal. Over a period of three weeks, the researchers used blood tests to measure the levels of BDNF in both groups of ...
Why people with attention-deficit/hyperactivity disorder (ADHD) are at greater risk of substance dependence, particularly methamphetamine dependence, and have greater difficulty overcoming their addiction is the subject of a new study by researchers at the UC Davis MIND Institute.
Objective: To investigate whether methamphetamine use is associated with sexual risk behavior among adolescents. Method: A cross-sectional survey of 1,561 male and female high school students in Cape Town (mean age 14.9 years) was conducted using items from the Problem Oriented Screening Instrument for Teenagers (POSIT) HIV Risk Scale. Results: Nine percent of the students had tried methamphetamine and 30% of male and 17% of female students reported sexual debut. Multinomial logistic regression analyses showed that methamphetamine use in the past year was significantly associated with being in a higher HIV/STI risk category (RRR = 2.1, 95% CI: 1.10-4.03, p & 0.05). Conclusions: Methamphetamine use, coupled with a high HIV prevalence in South Africa, raises serious cause for concern about the potential for methamphetamine to further exacerbate the prevalence and spread of HIV in Cape Town. © 2012 Taylor and Francis Group, LLC.. ...
The Methamphetamine Treatment Project is collaborative effort between community and state to address the growing incidence of Methamphetamine use and abuse among youth in the state of South Dakota. The project is comprised of four phases, (1) stabilization, (2) intensive treatment, (3) structured living, and (4) community placement. Each phase will build on the proceeding phase. Most treatment programs do not adequately address the special needs of the Methamphetamine dependent adolescent client.
Methamphetamine Addiction Rehab is here at Pinnacle Peak Recovery. People who use methamphetamine usually say that this drugs pleasurable high keeps ...
Methamphetamine (METH) use, especially in females, has become a growing public health concern in China. In this study, we aimed to characterize the factors that contributed to drug craving in female METH users under isolated compulsory detoxification. We characterized factors contributing to craving such as duration of detoxification, history of drug use and self-reported mood state. Subjects (N=113) undergoing a 1- to 3-year METH detoxification program were recruited from the Zhejiang Compulsory Detoxification Center for Women. The Questionnaire of METH-use Urge (QMU) was used to evaluate the level of craving for METH. The Abbreviate Profile of Mood States (A-POMS) was applied as an assessment for the negative mood disturbances. The participants were at a mean age of 25.2, primarily lowly educated and unemployed, and single. Smoking was the only route of METH administration at an average dose of 0.5 g/day, and 4 times/week. The reported craving level was positively correlated with the negative mood
Methamphetamine (METH) use, especially in females, has become a growing public health concern in China. In this study, we aimed to characterize the factors that contributed to drug craving in female METH users under isolated compulsory detoxification. We characterized factors contributing to craving such as duration of detoxification, history of drug use and self-reported mood state. Subjects (N=113) undergoing a 1- to 3-year METH detoxification program were recruited from the Zhejiang Compulsory Detoxification Center for Women. The Questionnaire of METH-use Urge (QMU) was used to evaluate the level of craving for METH. The Abbreviate Profile of Mood States (A-POMS) was applied as an assessment for the negative mood disturbances. The participants were at a mean age of 25.2, primarily lowly educated and unemployed, and single. Smoking was the only route of METH administration at an average dose of 0.5 g/day, and 4 times/week. The reported craving level was positively correlated with the negative mood
PubMed journal article: Determination and long-term stability of twenty-nine cathinones and amphetamine-type stimulants (ATS) in urine using gas chromatography-mass spectrometry. Download Prime PubMed App to iPhone, iPad, or Android
The National Amphetamine-Type Stimulant Strategy 2008-2011 (the Strategy) has been developed within the existing legislative framework and focuses on prevention, supply reduction and treatment in a partnership framework.. Page last updated: September 2008 ...
Study findings show the expansion of current amphetamine-type stimulants and overdose prevention and response efforts to address their use.
People who abused methamphetamine or other amphetamine-like stimulants were more likely to develop Parkinsons disease than those who did not, in a new study from the Centre for Addiction and Mental Health (CAMH).. The researchers examined almost 300,000 hospital records from California covering 16 years. Patients admitted to hospital for methamphetamine or amphetamine-use disorders had a 76 per cent higher risk of developing Parkinsons disease compared to those with no disorder.. Globally, methamphetamine and similar stimulants are the second most commonly used class of illicit drugs.. This study provides evidence of this association for the first time, even though it has been suspected for 30 years, said lead researcher Dr. Russell Callaghan, a scientist with CAMH. Parkinsons disease is caused by a deficiency in the brains ability to produce a chemical called dopamine. Because animal studies have shown that methamphetamine damages dopamine-producing areas in the brain, scientists have ...
TY - JOUR. T1 - Association between the regulator of G-protein signaling 9 gene and patients with methamphetamine use disorder and schizophrenia. AU - Okahisa, Y.. AU - Kodama, M.. AU - Takaki, M.. AU - Inada, T.. AU - Uchimura, N.. AU - Yamada, M.. AU - Iwata, N.. AU - Iyo, M.. AU - Sora, I.. AU - Ozaki, N.. AU - Ujike, H.. PY - 2011/3/30. Y1 - 2011/3/30. N2 - The regulator of G-protein signaling (RGS) modulates the functioning of heterotrimeric G protein. RGS9-2 is highly expressed in the striatum and plays a role in modulating dopaminergic receptor-mediated signaling cascades. Previous studies suggested that the RGS9 gene might contribute to the susceptibility to psychotic diseases. Therefore, we investigated the association between the RGS9 gene and two related dopamine psychoses, schizophrenia and methamphetamine use disorders. The subjects comprised 487 patients of schizophrenia and 464 age- and sex-matched healthy controls and 220 patients of methamphetamine use disorder and 289 controls. ...
Chronic abuse of methamphetamine can affect major organ systems, resulting in significant issues. Learn more about the dangers of methamphetamine abuse.
Methamphetamine addiction is a brain disorder and a chronic condition in which a person cannot stop using the drug methamphetamine, or meth.
A new study funded by the National Institute on Drug Abuse (NIDA) documents the high rates and unique patterns of dental decay and gum disease in people who use the illicit drug methamphetamine. The large study of 571 methamphetamine users found that 96 percent had experienced dental cavities and 58 percent had untreated tooth decay. Only 23 percent retained all of their natural teeth, compared to a tooth retention rate of 48 percent among the U.S. general population. The study was conducted by investigators at the University of California, Los Angeles (UCLA).. The study found that adults reporting moderate or heavy methamphetamine use were twice as likely to have untreated dental cavities than were light users (less than 10 days of use over the past month). Older subjects (ages 30+), women, and current cigarette smokers were disproportionately affected by dental and periodontal disease. In addition, a significant percentage of participants (40 percent) indicated they were often self-conscious ...
Methamphetamine is a stimulant commonly abused in many parts of the United States. Most methamphetamine users are white men 18 to 25 years of age, but the highest usage rates have been found in native Hawaiians, persons of more than one race, Native Americans, and men who have sex with men. Methamphetamine use produces a rapid, pleasurable rush followed by euphoria, heightened attention, and increased energy. Possible adverse effects include myocardial infarction, stroke, seizures, rhabdomyolysis, cardiomyopathy, psychosis, and death. Chronic methamphetamine use is associated with neurologic and psychiatric symptoms and changes in physical appearance. High-risk sexual activity and transmission of human immunodeficiency virus are also associated with methamphetamine use. Use of methamphetamine in women who are pregnant can cause placental abruption, intrauterine growth retardation, and preterm birth, and there can be adverse consequences in children exposed to the drug. Treatment of methamphetamine
Prenatal methamphetamine exposure (PME) is the exposure of a fetus to methamphetamine when a woman uses the drug during her pregnancy. Methamphetamine (MA) has shown increasing popularity in the past two decades among women of childbearing age. Methamphetamine is second only to cannabis as the most widely used illegal drug, which may be because it is relatively cheap and easy to manufacture. Yet, to this date, the effects of PME on the developing fetus have not been well characterized and even less is known regarding the effects on development in childhood. Although few studies have established a pattern of MA use in pregnant users, it is important that researchers seek to determine this pattern to examine a possible dose-response relationship between MA use and neonatal outcomes. The recent increase in MA use in the United States, particularly in the South and Midwest, highlights the need for a better understanding of the short-term and long-term effects of MA use during pregnancy upon newborns ...
Methamphetamine can increase the release and even block the reuptake of the brain chemical dopamine. This leads to higher levels of dopamine in the brain which is common for drug abusers. Dopamine is responsible for reward, experience of pleasure, motivation and motor function. Since methamphetamine has the ability to release dopamine quickly in the brain, the reward sections of the brain experience an intense euphoria or a rush once the drug has been smoked, snorted, or injected into the body.. Using methamphetamine for a long period of time can significantly change how the brain is able to function. These functions can include reduced motor skills and impaired verbal learning. In other studies conducted, it also shows that chronic methamphetamine abusers have severe structural and even functional changes in the brain; in the memory and emotion areas. This is why many of the abusers of the drug have problems with emotional and cognitive situations.. Using methamphetamine for an extended period ...
TY - JOUR. T1 - Body dissatisfaction and methamphetamine use among HIV-positive gay and bisexual men. T2 - A pilot study. AU - Theodore, Peter S.. AU - Achiro, Richard P.. AU - Duran, Ron E.F.. AU - Antoni, Michael H.. PY - 2011/10/24. Y1 - 2011/10/24. N2 - Methamphetamine use is strongly associated with risky sex and increased reports of HIV and other sexually transmitted infections among gay and bisexual men (GBM) who attend dance/circuit parties. The psychological mechanisms underlying methamphetamine use in this subculture, however, remain unclear. These exploratory findings are from a 2004 dataset measuring body dissatisfaction and drug use among 42 HIV-positive GBM in South Florida who attended at least one bar/club/circuit party within 3 months of participating. A multivariate regression model revealed that body dissatisfaction accounted for a small but significant amount of variance in methamphetamine use. Treatment implications and recommendations for future research are ...
TY - JOUR. T1 - Effects of chronic methamphetamine exposure on heart function in uninfected and retrovirus-infected mice. AU - Yu, Qianli. AU - Montes, Sergio. AU - Larson, Douglas F. AU - Watson, Ronald R. PY - 2002/7/12. Y1 - 2002/7/12. N2 - Methamphetamine (MA) increases catecholamine levels, which have detrimental effects on heart function through vasoconstriction, myocardial hypertrophy, and fibrosis. Murine retrovirus infection induces dilated cardiomyopathy (DCM). The present study investigated the cardiovascular effects of chronic MA treatment on uninfected and retrovirus-infected mice. C57BL/6 mice were studied after 12 weeks treatment. The four study groups were (group I) uninfected, MA placebo; (group II) infected, MA placebo; (group III) uninfected, MA treatment; and (group IV) infected and MA treatment. MA injections were given i.p. once a day for 5 days/week with a increasing dose from 15 mg/kg to 40 mg/kg. Left ventricular mechanics were measured in situ a using Millar conductance ...
Title: Progress in Understanding Basal Ganglia Dysfunction as a Common Target for Methamphetamine Abuse and HIV-1 Neurodegeneration. VOLUME: 5 ISSUE: 3. Author(s):Shaji Theodore, Wayne A. Cass, Avindra Nath and William F. Maragos. Affiliation:Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama, Birmingham 1719, 6th Avenue South, CIRC 516, Birmingham, AL-35294, USA.. Keywords:Drug abuse, AIDS, glia, cytokines, dopamine, striatum, neurodegeneration. Abstract: HIV-1 infection with concurrent methamphetamine (MA) abuse results in exacerbated neurodegenerative changes and rapid progression of a form of sub-cortical dementia termed HIV-1 associated dementia (HAD). A notable feature of HAD is the involvement of the dopaminergic system manifested as parkinsonian like movement abnormalities. The HIV-1 transactivator of transcription (Tat) protein is very often used in experimental studies trying to understand neurotoxic consequences of HIV-1 ...
wp-content/uploads/2017/11/fri-banner-logo-2.jpg 0 0 awp-admin /wp-content/uploads/2017/11/fri-banner-logo-2.jpg awp-admin2017-10-06 10:57:472017-10-06 10:57:47Methamphetamine Abuse Treatment Reduces HIV Risk Behaviors among Gay and Bisexual Males in Los Angeles, California, USA ...
A third potential indication in the treatment of substance use disorders is emerging for the medication MN-166 (ibudilast), a drug that is associated with glial cell activation. Biopharmaceutical company MediciNova has announced that the National Institute on Alcohol Abuse and Alcoholism (NIAAA) will fund a clinical trial of the medication for the treatment of alcohol dependence.. The latest news follows the companys 2013 announcements of a Phase 2 trial of the medication for the treatment of methamphetamine dependence and a phase 2a trial of the drug for the treatment of opioid addiction. Both of those studies have received National Institute on Drug Abuse (NIDA) funding. The availability of a medication to treat stimulant dependence would represent a long-awaited breakthrough in the addiction medicine community.. Lara Ray, PhD, associate professor at the UCLA Department of Psychiatry and Biobehavioral Sciences, will lead the study. Emerging research in the field of alcohol dependence has ...
Objective: Community studies and studies of admissions to drug treatment centers indicate a dramatic increase in the prevalence of methamphetamine use in Cape Town since 2003. There has also been a substantial increase over this time period in the prevalence of HIV infection among women attending public antenatal clinics in the Western Cape province. This study aimed to review research conducted in Cape Town on the link between methamphetamine use and sexual risk behaviour. Method: A review of published research conducted in Cape Town between 2004 and 2007 was undertaken using PubMed, EBSCOhost and Science Direct. Results: Eight studies were identified, both quantitative and qualitative, and focusing on diverse populations, such as learners in school, out of school youth, adults in the community, men who have sex with men and sex workers. The total sample across the studies was 8153. Across multiple studies methamphetamine was fairly consistently associated with early vaginal sex, condom use ...
TY - JOUR. T1 - Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure. AU - McFadden, Lisa M.. AU - Hadlock, Greg C.. AU - Allen, Scott C.. AU - Vieira-Brock, Paula L.. AU - Stout, Kristen A.. AU - Ellis, Jonathan D.. AU - Hoonakker, Amanda J.. AU - Andrenyak, David M.. AU - Nielsen, Shannon M.. AU - Wilkins, Diana G.. AU - Hanson, Glen R.. AU - Fleckenstein, Annette E.. PY - 2012/2/1. Y1 - 2012/2/1. N2 - Preclinical studies have demonstrated that repeated methamphetamine (METH) injections (referred to herein as a binge treatment) cause persistent dopaminergic deficits. A few studies have also examined the persistent neurochemical impact of METH self-administration in rats, but with variable results. These latter studies are important because: 1) they have relevance to the study of METH abuse; and 2) the effects of noncontingent METH treatment do not necessarily predict effects of ...
Methamphetamine is often a white or light brown crystalline powder. It can also be in liquid form. If you find it in your home, then that has to be the most obvious sign that someone is abusing it. Still, most adults will try to hide their use of illicit drugs, so getting this evidence might not be so easy.. If you fear that someone you love is abusing the drug-or is already addicted to it-there are a couple of signs you can look out for. If you find small pieces of crumpled aluminum foil lying around your house, thats another indication of drug abuse.. But meth abusers often do not sleep for long periods of time. They take meth until they run out, or until they are unable to maintain consciousness. They will rapidly and drastically lose their weight, becoming and appearing malnourished. This is an effect of methamphetamine abuse, wherein the user loses their appetite.. The drug is a stimulant, so the user will appear euphoric or active. They may also be more nervous or anxious for no ...
Leserman Robbins, J., Lorvick, J., Lutnick, A., Wenger, L., & Kral, A. (2012). Self-reported oral health needs and dental-care seeking behavior among women who use methamphetamine. Substance Use and Misuse, 47(11), 1208 - 1213 ...
Study Purpose: The purpose of the study was to provide information about markets, distribution, and use of methamphetamine in New York City, both inside and outside of the MSM (men who have sex with men)/gay community. The study had four specific aims. (1) Pilot a research design using mixed qualitative/quantitative data collection methods in New York City methamphetamine markets with participants recruited using Respondent Driven Sampling. (2) Document, describe, and analyze the demographics and methamphetamine abuse behaviors of a sample of methamphetamine market participants. (3) Document, describe, and analyze the social networks of New York City methamphetamine market participants as users, buyers, and sellers of methamphetamine. (4) Document, describe, and analyze the market behaviors of New York City methamphetamine market participants as users, buyers, and sellers of methamphetamine. Study Design: Researchers piloted a version of Respondent Driven Sampling (RDS) to recruit different ...
The prevalence of methamphetamine abuse during pregnancy in women seeking treatment tripled from 1994 to 2006, rising to 24% of all pregnant women admitted to federally funded treatment centers, according to the researchers. Eze and colleagues defined early adversity as the sum of multiple binary indicators, including self-reported maternal postnatal substance abuse, an annual household income less than $10,000, reported sexual or physical abuse by a caregiver, a maternal score on the Brief Symptom Inventory, maternal depression above average for the Beck Depression Inventory, quality of living environment below average on the HOME Inventory, community violence above average on the Lifestyle Interview, and social position below average for the Index of Social Position.. The researchers began recruiting for the Infant Development, Environment, and Lifestyle (IDEAL) longitudinal study in 2002. They enrolled 412 mother and infant pairs at four sites and identified participants as ...
Alcohol and meth have different functions. Alcohol is a sedative - a downer - and works as a central nervous system depressant, also called a CNS depressant. Its effects include nausea, impaired thinking, and slowed cardiovascular functioning. When consumed in large quantities, alcohol can cause dramatic mood swings, slurred speech, loss of motor skills coordination, and alcohol poisoning.. Methamphetamine, or meth, is a stimulant - an upper - and considered one of the most potent of its kind. It stimulates the central nervous system, leading to the occurrence of high blood pressure, increased energy, amplified heart rate, and euphoria. Medically, methamphetamine is an FDA-approved medication for treating ADHD and exogenous obesity in both children and adults.. Being addicted to methamphetamine and alcohol can increase the risk for alcohol poisoning. According to the New Research on Methamphetamine Abuse, ethanol or alcohol attenuates the effects of methamphetamine and slows down the metabolism ...
Ballard Michael E, Mandelkern Mark A, Monterosso John R, Hsu Eustace, Robertson Chelsea L, Ishibashi Kenji, Dean Andy C, London Edythe D Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2015; 18(7): pyu119 ...
THC (delta-9-tetrahydrocannnabinol).. Ice methamphetamine abuse levels are stable throughout the region; the drug is typically of high purity. Public health authorities report that most methamphetamine abusers are Caucasians and Hispanics and that female abusers outnumbered male abusers in the Atlanta MSA among individuals seeking treatment for the abuse of amphetamines, which include methamphetamine.. CPDs and MDMA are considerable threats to the Atlanta HIDTA region. The most widely available and commonly abused CPDs are hydrocodone, oxycodone, and diazepam. Law enforcement officials report that CPD abuse is a growing problem among Caucasian young adults. MDMA available in the Atlanta HIDTA region is generally abused in combination with other substances, including alcohol, cocaine, and marijuana. MDMA is most commonly available in Buckhead (northern Atlanta) and Midtown and is used mainly by Caucasian youths; however, MDMA abuse has increased among African Americans in the region. The abuse ...
WEDNESDAY, Aug. 21, 2019 (American Heart Association News) -- Although frequently overshadowed by the opioid epidemic, surging methamphetamine use nationally and around the world has fueled a chilling crisis of its own, according to a new report.. The result is a significant increase in meth-related deaths from unique cardiovascular consequences that researchers are trying to understand.. Methamphetamines can cause blood vessels to constrict and spasm, dangerous spikes in blood pressure, and the rewiring of the hearts electrical system, among other potentially fatal heart-related problems.. Cardiovascular disease represents the second-leading cause of death among methamphetamine abusers following only accidental overdose, according to the report published Wednesday in the American Heart Associations journal Arteriosclerosis, Thrombosis, and Vascular Biology.. The report reviews current research on methamphetamine and the drugs effect on heart disease and stroke. It discusses potential ...
Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived neurotrophic factor (BDNF) is implicated in both Meth effects and schizophrenia. We therefore studied the long-term effects of chronic Meth exposure in transgenic mice engineered to harbor the human BDNFVal66Met polymorphism expressed via endogenous mouse promoters. These mice were chronically treated with an escalating Meth regime during late adolescence. At least 4 weeks later, all hBDNFVal66Met Meth-treated mice exhibited sensitization confirming persistent behavioral effects of Meth. We used high-resolution quantitative mass spectrometry-based proteomics to biochemically map the long-term effects of Meth within the brain, resulting in the unbiased detection of 4808 proteins across the mesocorticolimbic circuitry. Meth differentially altered dopamine signaling markers (e.g., Dat, Comt, and Th) between hBDNFVal/Val and hBDNFMet
KOKOMO, Ind. - A teenager who died in a pursuit and crash last month in Kokomo was high on methamphetamine, investigators say. The Howard County Coroner
Wasp spray is becoming an increasingly popular alternative to methamphetamine, posing a whole new set of health risks, law enforcement officials say. The problem has become particularly bad in West Virginia, according to TV station KIRO. The wasp spray is inhaled or injected, providing a rush similar to the one methamphetamine users experience. Sometimes it is used alone, while other times it is used alongside methamphetamine to intensify effects. At least three overdoses have been reported so
Recent studies and research shows that People who use methamphetamine are almost five times more likely to have a stroke caused by a bleed in the brain, many of which are fatal. We can add stroke to the list of terrible and devastating things that methamphetamine does, says Damian Zuloaga, of the University at Albany, New York.. Beyond the signature tooth decay known as meth mouth, methamphetamine also increases heart rate and blood pressure, and can trigger heart attacks. The drug can lead to psychosis, and has been linked to anxiety disorders, depression, and problems with movement similar to those seen in Parkinsons disease.. A handful of studies have also linked methamphetamine use to strokes. To explore further, Julia Lappin and her colleagues at the Australian National Drug and Alcohol Research Centre in Sydney sifted through published research on the topic.. The team specifically looked for research into people under the age of 45 - a group less likely to be affected by age-related ...
The problem of methamphetamine use in todays society is an ever growing problem. Women of childbearing age are among this group, leading to an increasing number of children with prenatal methamphetamine exposure.. Christine Cloak, Ph.D., of the University of Hawaii, and colleagues findings are reported online in Neurology. The researchers did MRI scans on 29 methamphetamine-exposed children 3 to 4 years old, recruited from local hospitals, drug rehabilitation centers, and the community. Using detailed interviews of the mothers, the cumulative gestational methamphetamine exposure reported averaged 58 g over 2.5 trimesters, but varied widely.. Methamphetamine has been shown to cross the placenta and impact overall fetal growth. The drug is known to act on dopamine receptors that regulate corticogenesis and are present in the brain as early as the first trimester. It also affects other catecholamine systems involved in brain development.. Cloak and colleagues found that prenatal exposure to meth ...
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Mexican criminal groups have replaced traditional Asian criminal groups as the primary transporters of methamphetamine. Mexican criminal groups are the primary transporters of Mexico-produced methamphetamine as well as methamphetamine produced in California. Law enforcement officials report that Mexican criminal groups transport methamphetamine into Hawaii from the West Coast, primarily California. Mexican criminal groups transport both powdered and crystal methamphetamine. Some powdered methamphetamine is converted to crystal methamphetamine in Mexico and on the West Coast for transportation to Hawaii.. Traditional Asian transporters of crystal methamphetamine--primarily Korean, Japanese, Filipino, and Vietnamese criminal groups--also transport the drug into Hawaii, but to a lesser extent than during the mid-1980s to early 1990s. In the early 1990s law enforcement authorities in Hawaii dismantled several large Asian, primarily Korean, criminal groups that dominated the transportation of crystal ...
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Eighteen rats were implanted with intravenous (IV) catheters and bilateral AcbSh electrodes and subsequently underwent daily sessions in 2-lever (active/methamphetamine and inactive/no reward) operant chambers to establish IV methamphetamine self-administration. After stable responding was achieved, 3 hours of DBS or sham treatment was administered (sham: 0 µA, n = 8; active: 200 µA, n = 10) in a separate nondrug environment prior to the daily operant sessions for 5 consecutive days. Immediately following each DBS/sham treatment, rats were placed in the operant chambers to examine the effects of remote stimulation on methamphetamine intake. After the 5 days of therapy were finished, rats reestablished a posttreatment baseline, followed by extinction training, abstinence, and 1 day of relapse testing to assess methamphetamine-seeking behavior. ...
Methamphetamine exists as two enantiomers. The S(+) form, which is also called d methamphetamine, is an ingredient in a few legitimate pharmaceutical products available only by prescription, and can be illicitly synthesized from (-) ephedrine or (+) pseudoephedrine. The S(+) or d form of methamphetamine is generally considered a drug of abuse. On the other hand, the R(-) form, which is also called l-desoxyephedrine or l methamphetamine, is the active ingredient in Vicks inhalers, is a metabolite of the anti-Parkinson drug Selegiline, and is not a drug of abuse. When a specimen gives a confirmed positive result for methamphetamine, this test can be ordered. This test separates the enantiomers and will provide percentage-based information to help determine the source of methamphetamine in the specimen. Note that this test does not provide quantitations; it only provides the percentage(s) of each methamphetamine found in the urine. The urine should be previously tested for methamphetamine and ...
Methamphetamine, generally described as meth, is a highly-addictive neurotoxic energizer that is commonly described as one of the most hazardous medication on earth, due to the broad schedule, simplicity of usage, and also capacity to produce the medicine from normal home products. Most often, methamphetamine comes in two forms, Crystal Meth and also powdered meth, both generate comparable impacts on the customer.. Meth generates a false sense of well-being and joy. It gives the user a thrill, and an increase in feelings of power, confidence, and also wakefulness. These results generally last six to eight hrs, however can be sustained for upwards of twelve hrs.. Methamphetamine is merely and also cheaply made using different family products in about two days- start to complete. The key component in methamphetamine is pseudoephedrine or ephedrine, both of which are discovered in a wide variety of over the counter chilly treatments.. ...
Revive Therapeutics reported it has entered into clinical trial agreement with the University of Wisconsin-Madison to evaluate the use of psilocybin for the treatment of methamphetamine use disorder.
Drug injection and other practices affecting the risk of human immunodeficiency virus HIV infection were studied among 154 heroin users and 45 methamphetamine users in San Antonio, Texas. Amphetamine users were younger, mostly white, and had less-severe drug dependence. Heroin users had significantly higher levels of needle risk, as indicated...
Professor Yamamoto at Indiana University, and his collaborators, are cooking up new explanations for why stress and meth use are a common toxic mix
Methamphetamine meaning in Hindi : Get meaning and translation of Methamphetamine in Hindi language with grammar,antonyms,synonyms and sentence usages. Know answer of question : what is meaning of Methamphetamine in Hindi? Methamphetamine ka matalab hindi me kya hai (Methamphetamine का हिंदी में मतलब ). Methamphetamine meaning in Hindi (हिन्दी मे मीनिंग ) is मेथैंफ़ेटामीन.English definition of Methamphetamine : an amphetamine derivative (trade name Methedrine) used in the form of a crystalline hydrochloride; used as a stimulant to the nervous system and as an appetite suppressant
TY - JOUR. T1 - Neurotoxic effects of methamphetamine. AU - Thrash, Bessy. AU - Karuppagounder, Senthilkumar S.. AU - Uthayathas, Subramaniam. AU - Suppiramaniam, Vishnu. AU - Dhanasekaran, Muralikrishnan. PY - 2010/1/1. Y1 - 2010/1/1. N2 - In Parkinsons disease, depletion of dopamine in the striatum leads to various symptoms such as tremor, rigidity and akinesia. Methamphetamine use has significantly increased in USA and around the world and there are several reports showing that its long-term use increases the risk for dopamine depletion. However, the toxic mechanisms of methamphetamine are not well understood. This study was undertaken to gain greater mechanistic understanding of the toxicity induced by methamphetamine. We evaluated the effect of methamphetamine on the generation of reactive oxygen species, mitochondrial monoamine oxidase, complex I & IV activities. Behavioral analysis evaluated the effect on catalepsy, akinesia and swim score. Neurotransmitter levels were evaluated using ...
The negative impacts of the illicit drug trade touch every society in the world. The World Drug Report for 2005 estimates that 200 million people, or 5% of the global population age 15-64, have consumed illicit drugs at least once in the last 12 months. The UN Office on Drugs and Crime (UNODC) estimates its worldwide retail value to be $321bn. It impacts almost every level of human security from individual health, to safety and social welfare. Its consequences are especially devastating for countries with limited resources available to fight against it.. The World Drug Report 2007 places the UK in joint first place with Denmark (out of 30 European countries) for amphetamine use and in fifth place for ecstasy use. The report states that although still tiny compared to amphetamine, the amount of methamphetamine seized in Europe rose more than four-fold between 2000 and 2005.. Chemical Dependency. Chemical dependency has many faces and takes many forms, including the use of depressants, stimulants, ...
Inpatient treatment care for meth abuse or addiction provides 24-hour medical assistance and a team of therapy professionals in a safe environment. Medically supervised detoxification is the first step in the process, along with medication management, wellness services, counseling and group therapy. In this type of treatment, you will be able to meet other people who are overcoming addiction, working on solutions to enjoy life without dependence on this destructive drug.. Outpatient care is also a great option, one that may allow you to keep your job or school or other responsibilities going while you get treatment. Patients can return to sober living or to their own home each evening. Regular appointments are scheduled around other obligations, but patients should attend all appointments to get the full benefit of their treatment program.. If patients or loved ones have questions, those can be addressed in consultation with the treatment program professionals. Each patient and family member ...
A new nasal decongestant is available over the counter for those who suffer from allergies. Zyprex D is being pseudoephedrine that is being promoted not only for its medical value, but for being meth-resistant as well.